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Yvonne Kapila, DDS, PhD

TitleProfessor
SchoolUCSF School of Dentistry
DepartmentOrofacial Sciences
Address513 Parnassus Avenue
San Francisco CA 94117
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    Collapse Research 
    Collapse Research Activities and Funding
    Oral Treponema Surface Proteins: Host Cell Interactions
    NIH/NIDCR R01DE025225Jul 1, 2015 - May 31, 2020
    Role: Co-Principal Investigator
    Biomarkers of Aggressive Oral Cancer
    NIH/NIDCR R56DE023333Sep 25, 2013 - Aug 31, 2015
    Role: Principal Investigator
    FIBRONECTIN REGULATION OF CARCINOMA APOPTOSIS
    NIH/NIDCR R01DE014429Sep 15, 2004 - Jun 30, 2010
    Role: Principal Investigator
    Fibronectin Regulation of Anoikis
    NIH/NIDCR R56DE014429Dec 1, 2001 - Apr 30, 2012
    Role: Principal Investigator
    Apoptosis Regulated by Fibronectin Signaling Pathways
    NIH/NIDCR R01DE013725Apr 1, 2000 - Sep 30, 2011
    Role: Principal Investigator
    FIBRONECTIN INTERACTIONS WITH PERIODONTAL LIGAMENT CELLS
    NIH/NIDCR K15DE000344Dec 15, 1993 - Dec 14, 1998
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Maska B, Lin GH, Othman A, Behdin S, Travan S, Benavides E, Kapila Y. Dental implants and grafting success remain high despite large variations in maxillary sinus mucosal thickening. Int J Implant Dent. 2017 Dec; 3(1):1. PMID: 28101784.
      View in: PubMed
    2. Shin JM, Kamarajan P, Fenno JC, Rickard AH, Kapila Y. Metabolomics of Head and Neck Cancer: A Mini-Review. Front Physiol. 2016; 7:526. PMID: 27877135.
      View in: PubMed
    3. Dabiri D, Fontana M, Kapila Y, Eckert G, Sokal-Gutierrez K. Community-based assessment and intervention for early childhood caries in rural El Salvador. Int Dent J. 2016 Aug; 66(4):221-8. PMID: 27080395.
      View in: PubMed
    4. Shin JM, Gwak JW, Kamarajan P, Fenno JC, Rickard AH, Kapila Y. Biomedical applications of nisin. J Appl Microbiol. 2016 Jun; 120(6):1449-65. PMID: 26678028; PMCID: PMC4866897 [Available on 06/01/17].
    5. Alhazzazi TY, Kamarajan P, Xu Y, Ai T, Chen L, Verdin E, Kapila Y. A Novel Sirtuin-3 Inhibitor, LC-0296, Inhibits Cell Survival and Proliferation, and Promotes Apoptosis of Head and Neck Cancer Cells. Anticancer Res. 2016 Jan; 36(1):49-60. PMID: 26722027.
      View in: PubMed
    6. Godovikova V, Goetting-Minesky MP, Shin JM, Kapila Y, Rickard AH, Fenno JC. A Modified Shuttle Plasmid Facilitates Expression of a Flavin Mononucleotide-Based Fluorescent Protein in Treponema denticola ATCC 35405. Appl Environ Microbiol. 2015 Sep; 81(18):6496-504. PMID: 26162875; PMCID: PMC4542240.
    7. Crouch S, Farkash J, Branch A, Vasconcellos L, Veronesi G, Kapila Y. To Brazil and Back: An International Dental Student Exchange Program. J Mich Dent Assoc. 2015 Jul; 97(7):40, 42-3. PMID: 26292504.
      View in: PubMed
    8. Kamarajan P, Hayami T, Matte B, Liu Y, Danciu T, Ramamoorthy A, Worden F, Kapila S, Kapila Y. Nisin ZP, a Bacteriocin and Food Preservative, Inhibits Head and Neck Cancer Tumorigenesis and Prolongs Survival. PLoS One. 2015; 10(7):e0131008. PMID: 26132406; PMCID: PMC4489501.
    9. Joo NE, Miao D, Bermúdez M, Stallcup WB, Kapila Y. Shedding of NG2 by MMP-13 attenuates anoikis. DNA Cell Biol. 2014 Dec; 33(12):854-62. PMID: 25166220; PMCID: PMC4248241.
    10. Miao D, Godovikova V, Qian X, Seshadrinathan S, Kapila Y, Fenno JC. Treponema denticola upregulates MMP-2 activation in periodontal ligament cells: interplay between epigenetics and periodontal infection. Arch Oral Biol. 2014 Oct; 59(10):1056-64. PMID: 24973519; PMCID: PMC4120104.
    11. Lesch A, Pisano J, Kapila Y. The student perspective: international exchange programs. J Mich Dent Assoc. 2014 Jun; 96(6):33-4. PMID: 25007466.
      View in: PubMed
    12. Tsai CY, Garaicoa-Pazmino C, Mori K, Benavides E, Kaigler D, Kapila Y. Implant success remains high despite grafting voids in the maxillary sinus. Clin Oral Implants Res. 2015 Apr; 26(4):447-53. PMID: 24720484.
      View in: PubMed
    13. Abuhussein H, Bashutski JD, Dabiri D, Halubai S, Layher M, Klausner C, Makhoul H, Kapila Y. The role of factors associated with apoptosis in assessing periodontal disease status. J Periodontol. 2014 Aug; 85(8):1086-95. PMID: 24359166.
      View in: PubMed
    14. Alhazzazi TY, Kamarajan P, Verdin E, Kapila Y. Sirtuin-3 (SIRT3) and the Hallmarks of Cancer. Genes Cancer. 2013 Mar; 4(3-4):164-71. PMID: 24020007; PMCID: PMC3764471.
    15. Makhoul H, Bashutski J, Halubai S, Dabiri D, Benavides E, Kapila Y. Apoptotic activity of gingival crevicular fluid from localized aggressive periodontitis. J Int Acad Periodontol. 2013 Jan; 15(1):2-7. PMID: 23413626.
      View in: PubMed
    16. Joo NE, Ritchie K, Kamarajan P, Miao D, Kapila Y. Nisin, an apoptogenic bacteriocin and food preservative, attenuates HNSCC tumorigenesis via CHAC1. Cancer Med. 2012 Dec; 1(3):295-305. PMID: 23342279; PMCID: PMC3544465.
    17. Tripathi P, Kamarajan P, Somashekar BS, MacKinnon N, Chinnaiyan AM, Kapila Y, Rajendiran TM, Ramamoorthy A. Delineating metabolic signatures of head and neck squamous cell carcinoma: phospholipase A2, a potential therapeutic target. Int J Biochem Cell Biol. 2012 Nov; 44(11):1852-61. PMID: 22743333; PMCID: PMC3455146.
    18. Kamarajan P, Alhazzazi TY, Danciu T, D'silva NJ, Verdin E, Kapila Y. Receptor-interacting protein (RIP) and Sirtuin-3 (SIRT3) are on opposite sides of anoikis and tumorigenesis. Cancer. 2012 Dec 1; 118(23):5800-10. PMID: 22674009; PMCID: PMC3443499.
    19. Somashekar BS, Kamarajan P, Danciu T, Kapila Y, Chinnaiyan AM, Rajendiran TM, Ramamoorthy A. Magic angle spinning NMR-based metabolic profiling of head and neck squamous cell carcinoma tissues. J Proteome Res. 2011 Nov 4; 10(11):5232-41. PMID: 21961579; PMCID: PMC3208743.
    20. Alhazzazi TY, Kamarajan P, Verdin E, Kapila Y. SIRT3 and cancer: tumor promoter or suppressor? Biochim Biophys Acta. 2011 Aug; 1816(1):80-8. PMID: 21586315; PMCID: PMC3129516.
    21. Hayami T, Kapila YL, Kapila Y. Divergent upstream osteogenic events contribute to the differential modulation of MG63 cell osteoblast differentiation by MMP-1 (collagenase-1) and MMP-13 (collagenase-3). Matrix Biol. 2011 May; 30(4):281-9. PMID: 21539914; PMCID: PMC3116144.
    22. Marchesan JT, Scanlon CS, Soehren S, Matsuo M, Kapila Y. Implications of cultured periodontal ligament cells for the clinical and experimental setting: a review. Arch Oral Biol. 2011 Oct; 56(10):933-43. PMID: 21470594; PMCID: PMC3132241.
    23. Scanlon C, Marchesan J, Soehren S, Matsuo M, Kapila Y. Capturing the regenerative potential of periodontal ligament fibroblasts. J Stem Cells Regen Med. 2011; 7(1):54-6. PMID: 21738334.
      View in: PubMed
    24. Alhazzazi TY, Kamarajan P, Joo N, Huang JY, Verdin E, D'Silva NJ, Kapila Y. Sirtuin-3 (SIRT3), a novel potential therapeutic target for oral cancer. Cancer. 2011 Apr 15; 117(8):1670-8. PMID: 21472714; PMCID: PMC3117020.
    25. Miao D, Fenno JC, Timm JC, Joo NE, Kapila Y. The Treponema denticola chymotrypsin-like protease dentilisin induces matrix metalloproteinase-2-dependent fibronectin fragmentation in periodontal ligament cells. Infect Immun. 2011 Feb; 79(2):806-11. PMID: 21115719; PMCID: PMC3028863.
    26. Bunek J, Kamarajan P, Kapila Y. Anoikis mediators in oral squamous cell carcinoma. Oral Dis. 2011 May; 17(4):355-61. PMID: 21114588; PMCID: PMC3072433.
    27. Pirih FQ, Michalski MN, Cho SW, Koh AJ, Berry JE, Ghaname E, Kamarajan P, Bonnelye E, Ross CW, Kapila Y, Jurdic P, McCauley LK. Parathyroid hormone mediates hematopoietic cell expansion through interleukin-6. PLoS One. 2010 Oct 27; 5(10):e13657. PMID: 21048959; PMCID: PMC2965090.
    28. Ghosh A, Chen TC, Kapila Y. Anoikis triggers Mdm2-dependent p53 degradation. Mol Cell Biochem. 2010 Oct; 343(1-2):201-9. PMID: 20577896; PMCID: PMC2943547.
    29. Kamarajan P, Garcia-Pardo A, D'Silva NJ, Kapila Y. The CS1 segment of fibronectin is involved in human OSCC pathogenesis by mediating OSCC cell spreading, migration, and invasion. BMC Cancer. 2010 Jun 25; 10:330. PMID: 20579373; PMCID: PMC3146068.
    30. Paula-Silva FW, Ghosh A, Arzate H, Kapila S, da Silva LA, Kapila Y. Calcium hydroxide promotes cementogenesis and induces cementoblastic differentiation of mesenchymal periodontal ligament cells in a CEMP1- and ERK-dependent manner. Calcif Tissue Int. 2010 Aug; 87(2):144-57. PMID: 20440482.
      View in: PubMed
    31. Ghosh A, Joo NE, Chen TC, Kapila Y. Proapoptotic fibronectin fragment induces the degradation of ubiquitinated p53 via proteasomes in periodontal ligament cells. J Periodontal Res. 2010 Aug; 45(4):481-7. PMID: 20337881; PMCID: PMC2894266.
    32. Paula-Silva FW, da Silva LA, Kapila Y. Matrix metalloproteinase expression in teeth with apical periodontitis is differentially modulated by the modality of root canal treatment. J Endod. 2010 Feb; 36(2):231-7. PMID: 20113780; PMCID: PMC2818380.
    33. Joseph J, Kapila YL, Hayami T, Kapila Y. Disease-associated extracellular matrix suppresses osteoblastic differentiation of human periodontal ligament cells via MMP-1. Calcif Tissue Int. 2010 Feb; 86(2):154-62. PMID: 19953231; PMCID: PMC3152822.
    34. Kamarajan P, Bunek J, Lin Y, Nunez G, Kapila Y. Receptor-interacting protein shuttles between cell death and survival signaling pathways. Mol Biol Cell. 2010 Feb 1; 21(3):481-8. PMID: 19955213; PMCID: PMC2814792.
    35. Daniels TE, Kapila Y. Comments on atrophic lingual papillae and candidiasis in Sjögren syndrome. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010 Jan; 109(1):4; author reply 4. PMID: 19828340.
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    36. de Paula-Silva FW, D'Silva NJ, da Silva LA, Kapila Y. High matrix metalloproteinase activity is a hallmark of periapical granulomas. J Endod. 2009 Sep; 35(9):1234-42. PMID: 19720222; PMCID: PMC2736957.
    37. Xu J, Wang W, Kapila Y, Lotz J, Kapila S. Multiple differentiation capacity of STRO-1+/CD146+ PDL mesenchymal progenitor cells. Stem Cells Dev. 2009 Apr; 18(3):487-96. PMID: 18593336; PMCID: PMC2702120.
    38. Paula-Silva FW, Ghosh A, Silva LA, Kapila Y. TNF-alpha promotes an odontoblastic phenotype in dental pulp cells. J Dent Res. 2009 Apr; 88(4):339-44. PMID: 19407154; PMCID: PMC3144054.
    39. Ghosh A, Park JY, Fenno C, Kapila Y. Porphyromonas gingivalis, gamma interferon, and a proapoptotic fibronectin matrix form a synergistic trio that induces c-Jun N-terminal kinase 1-mediated nitric oxide generation and cell death. Infect Immun. 2008 Dec; 76(12):5514-23. PMID: 18838522; PMCID: PMC2583576.
    40. Hayami T, Kapila YL, Kapila Y. MMP-1 (collagenase-1) and MMP-13 (collagenase-3) differentially regulate markers of osteoblastic differentiation in osteogenic cells. Matrix Biol. 2008 Oct; 27(8):682-92. PMID: 18755271; PMCID: PMC2683744.
    41. Joo NE, Watanabe T, Chen C, Chekenya M, Stallcup WB, Kapila Y. NG2, a novel proapoptotic receptor, opposes integrin alpha4 to mediate anoikis through PKCalpha-dependent suppression of FAK phosphorylation. Cell Death Differ. 2008 May; 15(5):899-907. PMID: 18292781; PMCID: PMC3940336.
    42. Kamarajan P, Kapila Y. An altered fibronectin matrix induces anoikis of human squamous cell carcinoma cells by suppressing integrin alpha v levels and phosphorylation of FAK and ERK. Apoptosis. 2007 Dec; 12(12):2221-31. PMID: 17879163.
      View in: PubMed
    43. Hayami T, Zhang Q, Kapila Y, Kapila Y. Dexamethasone's enhancement of osteoblastic markers in human periodontal ligament cells is associated with inhibition of collagenase expression. Bone. 2007 Jan; 40(1):93-104. PMID: 16934542.
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    44. Dai R, Iwama A, Wang S, Kapila Y. Disease-associated fibronectin matrix fragments trigger anoikis of human primary ligament cells: p53 and c-myc are suppressed. Apoptosis. 2005 May; 10(3):503-12. PMID: 15909113.
      View in: PubMed
    45. Tafolla E, Wang S, Wong B, Leong J, Kapila Y. JNK1 and JNK2 oppositely regulate p53 in signaling linked to apoptosis triggered by an altered fibronectin matrix: JNK links FAK and p53. J Biol Chem. 2005 May 20; 280(20):19992-9. PMID: 15778501.
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    46. Lu H, Jin D, Kapila Y. Application of laser capture microdissection to phage display peptide library screening. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2004 Dec; 98(6):692-7. PMID: 15583542.
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    47. Zhang Y, Lu H, Dazin P, Kapila Y. Squamous cell carcinoma cell aggregates escape suspension-induced, p53-mediated anoikis: fibronectin and integrin alphav mediate survival signals through focal adhesion kinase. J Biol Chem. 2004 Nov 12; 279(46):48342-9. PMID: 15331608.
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    48. Zhang Y, Lu H, Dazin P, Kapila Y. Functional differences between integrin alpha4 and integrins alpha5/alphav in modulating the motility of human oral squamous carcinoma cells in response to the V region and heparin-binding domain of fibronectin. Exp Cell Res. 2004 Apr 15; 295(1):48-58. PMID: 15051489.
      View in: PubMed
    49. Jee SW, Wang S, Kapila Y. Specific pro-apoptotic fibronectin fragments modulate proteinase expression in periodontal ligament cells. J Periodontol. 2004 Apr; 75(4):523-30. PMID: 15152815.
      View in: PubMed
    50. Iwama A, Nishigaki N, Nakamura K, Imaizumi I, Shibata N, Yamasaki M, Nakamura H, Kameyama Y, Kapila Y. The effect of high sugar intake on the development of periradicular lesions in rats with type 2 diabetes. J Dent Res. 2003 Apr; 82(4):322-5. PMID: 12651940.
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    51. Shiga M, Kapila Y, Zhang Q, Hayami T, Kapila S. Ascorbic acid induces collagenase-1 in human periodontal ligament cells but not in MC3T3-E1 osteoblast-like cells: potential association between collagenase expression and changes in alkaline phosphatase phenotype. J Bone Miner Res. 2003 Jan; 18(1):67-77. PMID: 12510807.
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    52. Huynh QN, Wang S, Tafolla E, Gansky SA, Kapila S, Armitage GC, Kapila Y. Specific fibronectin fragments as markers of periodontal disease status. J Periodontol. 2002 Oct; 73(10):1101-10. PMID: 12416766.
      View in: PubMed
    53. Kapila Y, Wang S, Dazin P, Tafolla E, Mass MJ. The heparin-binding domain and V region of fibronectin regulate apoptosis by suppression of p53 and c-myc in human primary cells. J Biol Chem. 2002 Mar 8; 277(10):8482-91. PMID: 11751853.
      View in: PubMed
    54. Kapila Y, Doan D, Tafolla E, Fletterick R. Three-dimensional structural analysis of fibronectin heparin-binding domain mutations. J Cell Biochem Suppl. 2001; Suppl 36:156-61. PMID: 11455580.
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    55. Hu B, Kapila YL, Buddhikot M, Shiga M, Kapila Y. Coordinate induction of collagenase-1, stromelysin-1 and urokinase plasminogen activator (uPA) by the 120-kDa cell-binding fibronectin fragment in fibrocartilaginous cells: uPA contributes to activation of procollagenase-1. Matrix Biol. 2000 Dec; 19(7):657-69. PMID: 11102755.
      View in: PubMed
    56. Kapila Y, Wang S, Johnson PW. Mutations in the heparin binding domain of fibronectin in cooperation with the V region induce decreases in pp125(FAK) levels plus proteoglycan-mediated apoptosis via caspases. J Biol Chem. 1999 Oct 22; 274(43):30906-13. PMID: 10521484.
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    57. Kapila Y, Lancero H, Johnson PW. The response of periodontal ligament cells to fibronectin. J Periodontol. 1998 Sep; 69(9):1008-19. PMID: 9776029.
      View in: PubMed
    58. Kapila Y, Niu J, Johnson PW. The high affinity heparin-binding domain and the V region of fibronectin mediate invasion of human oral squamous cell carcinoma cells in vitro. J Biol Chem. 1997 Jul 25; 272(30):18932-8. PMID: 9228073.
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    59. Kapila Y, Kashani H. Cocaine-associated rapid gingival recession and dental erosion. A case report. J Periodontol. 1997 May; 68(5):485-8. PMID: 9182745.
      View in: PubMed
    60. Kapila YL, Kapila Y, Johnson PW. Fibronectin and fibronectin fragments modulate the expression of proteinases and proteinase inhibitors in human periodontal ligament cells. Matrix Biol. 1996 Sep; 15(4):251-61. PMID: 8892225.
      View in: PubMed
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