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Yvonne Kapila, DDS, PhD

TitleProfessor
InstitutionUniversity of California San Francisco
DepartmentOrofacial Sciences
Address513 Parnassus Avenue
San Francisco CA 94117
Phone415-502-4683
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    Collapse Research 
    Collapse Research Activities and Funding
    Oral Treponema Surface Proteins: Host Cell Interactions
    NIH/NIDCR R01DE025225Jul 1, 2015 - May 31, 2020
    Role: Co-Principal Investigator
    Biomarkers of Aggressive Oral Cancer
    NIH/NIDCR R56DE023333Sep 25, 2013 - Aug 31, 2015
    Role: Principal Investigator
    FIBRONECTIN REGULATION OF CARCINOMA APOPTOSIS
    NIH/NIDCR R01DE014429Sep 15, 2004 - Jun 30, 2010
    Role: Principal Investigator
    Fibronectin Regulation of Anoikis
    NIH/NIDCR R56DE014429Dec 1, 2001 - Apr 30, 2012
    Role: Principal Investigator
    Apoptosis Regulated by Fibronectin Signaling Pathways
    NIH/NIDCR R01DE013725Apr 1, 2000 - Sep 30, 2011
    Role: Principal Investigator
    FIBRONECTIN INTERACTIONS WITH PERIODONTAL LIGAMENT CELLS
    NIH/NIDCR K15DE000344Dec 15, 1993 - Dec 14, 1998
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Chapple ILC, Mealey BL, Van Dyke TE, Bartold PM, Dommisch H, Eickholz P, Geisinger ML, Genco RJ, Glogauer M, Goldstein M, Griffin TJ, Holmstrup P, Johnson GK, Kapila Y, Lang NP, Meyle J, Murakami S, Plemons J, Romito GA, Shapira L, Tatakis DN, Teughels W, Trombelli L, Walter C, Wimmer G, Xenoudi P, Yoshie H. Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. J Clin Periodontol. 2018 Jun; 45 Suppl 20:S68-S77. PMID: 29926499.
      View in: PubMed
    2. Chapple ILC, Mealey BL, Van Dyke TE, Bartold PM, Dommisch H, Eickholz P, Geisinger ML, Genco RJ, Glogauer M, Goldstein M, Griffin TJ, Holmstrup P, Johnson GK, Kapila Y, Lang NP, Meyle J, Murakami S, Plemons J, Romito GA, Shapira L, Tatakis DN, Teughels W, Trombelli L, Walter C, Wimmer G, Xenoudi P, Yoshie H. Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. J Periodontol. 2018 Jun; 89 Suppl 1:S74-S84. PMID: 29926944.
      View in: PubMed
    3. Garcia J, Dodge A, Luepke P, Wang HL, Kapila Y, Lin GH. Effect of membrane exposure on guided bone regeneration: A systematic review and meta-analysis. Clin Oral Implants Res. 2018 Mar; 29(3):328-338. PMID: 29368353.
      View in: PubMed
    4. Ateia IM, Sutthiboonyapan P, Kamarajan P, Jin T, Godovikova V, Kapila Y, Fenno JC. Treponema denticola increases MMP-2 expression and activation in the periodontium via reversible DNA and histone modifications. Cell Microbiol. 2018 Apr; 20(4). PMID: 29205773.
      View in: PubMed
    5. Reddy RM, Weir WB, Barnett S, Heiden BT, Orringer MB, Lin J, Chang AC, Carrott PW, Lynch WR, Beer DG, Fenno JC, Kapila Y. Increased Variance in Oral and Gastric Microbiome Correlates With Esophagectomy Anastomotic Leak. Ann Thorac Surg. 2018 Mar; 105(3):865-870. PMID: 29307454.
      View in: PubMed
    6. Lin GH, Kapila Y, Wang HL. Parameters to Define Peri-Implantitis: A Review and a Proposed Multi-Domain Scale. J Oral Implantol. 2017 Dec; 43(6):491-496. PMID: 28873021.
      View in: PubMed
    7. Shin JM, Luo T, Kamarajan P, Fenno JC, Rickard AH, Kapila Y. Microbial Communities Associated with Primary and Metastatic Head and Neck Squamous Cell Carcinoma - A High Fusobacterial and Low Streptococcal Signature. Sci Rep. 2017 Aug 30; 7(1):9934. PMID: 28855542.
      View in: PubMed
    8. Kajwadkar R, Shin JM, Lin GH, Fenno JC, Rickard AH, Kapila Y. High-purity Nisin Alone or in Combination with Sodium Hypochlorite Is Effective against Planktonic and Biofilm Populations of Enterococcus faecalis. J Endod. 2017 Jun; 43(6):989-994. PMID: 28457635.
      View in: PubMed
    9. Kamarajan P, Rajendiran TM, Kinchen J, Bermúdez M, Danciu T, Kapila Y. Head and Neck Squamous Cell Carcinoma Metabolism Draws on Glutaminolysis, and Stemness Is Specifically Regulated by Glutaminolysis via Aldehyde Dehydrogenase. J Proteome Res. 2017 03 03; 16(3):1315-1326. PMID: 28168879.
      View in: PubMed
    10. Maska B, Lin GH, Othman A, Behdin S, Travan S, Benavides E, Kapila Y. Dental implants and grafting success remain high despite large variations in maxillary sinus mucosal thickening. Int J Implant Dent. 2017 Dec; 3(1):1. PMID: 28101784.
      View in: PubMed
    11. Shin JM, Kamarajan P, Fenno JC, Rickard AH, Kapila Y. Metabolomics of Head and Neck Cancer: A Mini-Review. Front Physiol. 2016; 7:526. PMID: 27877135.
      View in: PubMed
    12. Dabiri D, Fontana M, Kapila Y, Eckert G, Sokal-Gutierrez K. Community-based assessment and intervention for early childhood caries in rural El Salvador. Int Dent J. 2016 Aug; 66(4):221-8. PMID: 27080395.
      View in: PubMed
    13. Alhazzazi TY, Kamarajan P, Xu Y, Ai T, Chen L, Verdin E, Kapila Y. A Novel Sirtuin-3 Inhibitor, LC-0296, Inhibits Cell Survival and Proliferation, and Promotes Apoptosis of Head and Neck Cancer Cells. Anticancer Res. 2016 Jan; 36(1):49-60. PMID: 26722027.
      View in: PubMed
    14. Godovikova V, Goetting-Minesky MP, Shin JM, Kapila Y, Rickard AH, Fenno JC. A Modified Shuttle Plasmid Facilitates Expression of a Flavin Mononucleotide-Based Fluorescent Protein in Treponema denticola ATCC 35405. Appl Environ Microbiol. 2015 Sep; 81(18):6496-504. PMID: 26162875; PMCID: PMC4542240.
    15. Crouch S, Farkash J, Branch A, Vasconcellos L, Veronesi G, Kapila Y. To Brazil and Back: An International Dental Student Exchange Program. J Mich Dent Assoc. 2015 Jul; 97(7):40, 42-3. PMID: 26292504.
      View in: PubMed
    16. Kamarajan P, Hayami T, Matte B, Liu Y, Danciu T, Ramamoorthy A, Worden F, Kapila S, Kapila Y. Nisin ZP, a Bacteriocin and Food Preservative, Inhibits Head and Neck Cancer Tumorigenesis and Prolongs Survival. PLoS One. 2015; 10(7):e0131008. PMID: 26132406; PMCID: PMC4489501.
    17. Shin JM, Ateia I, Paulus JR, Liu H, Fenno JC, Rickard AH, Kapila Y. Antimicrobial nisin acts against saliva derived multi-species biofilms without cytotoxicity to human oral cells. Front Microbiol. 2015; 6:617. PMID: 26150809; PMCID: PMC4471743.
    18. Joo NE, Miao D, Bermúdez M, Stallcup WB, Kapila Y. Shedding of NG2 by MMP-13 attenuates anoikis. DNA Cell Biol. 2014 Dec; 33(12):854-62. PMID: 25166220; PMCID: PMC4248241.
    19. Miao D, Godovikova V, Qian X, Seshadrinathan S, Kapila Y, Fenno JC. Treponema denticola upregulates MMP-2 activation in periodontal ligament cells: interplay between epigenetics and periodontal infection. Arch Oral Biol. 2014 Oct; 59(10):1056-64. PMID: 24973519; PMCID: PMC4120104.
    20. Lesch A, Pisano J, Kapila Y. The student perspective: international exchange programs. J Mich Dent Assoc. 2014 Jun; 96(6):33-4. PMID: 25007466.
      View in: PubMed
    21. Tsai CY, Garaicoa-Pazmino C, Mori K, Benavides E, Kaigler D, Kapila Y. Implant success remains high despite grafting voids in the maxillary sinus. Clin Oral Implants Res. 2015 Apr; 26(4):447-53. PMID: 24720484.
      View in: PubMed
    22. Abuhussein H, Bashutski JD, Dabiri D, Halubai S, Layher M, Klausner C, Makhoul H, Kapila Y. The role of factors associated with apoptosis in assessing periodontal disease status. J Periodontol. 2014 Aug; 85(8):1086-95. PMID: 24359166.
      View in: PubMed
    23. Kamarajan P, Shin JM, Qian X, Matte B, Zhu JY, Kapila Y. ADAM17-mediated CD44 cleavage promotes orasphere formation or stemness and tumorigenesis in HNSCC. Cancer Med. 2013 Dec; 2(6):793-802. PMID: 24403253; PMCID: PMC3892384.
    24. Alhazzazi TY, Kamarajan P, Verdin E, Kapila Y. Sirtuin-3 (SIRT3) and the Hallmarks of Cancer. Genes Cancer. 2013 Mar; 4(3-4):164-71. PMID: 24020007; PMCID: PMC3764471.
    25. Makhoul H, Bashutski J, Halubai S, Dabiri D, Benavides E, Kapila Y. Apoptotic activity of gingival crevicular fluid from localized aggressive periodontitis. J Int Acad Periodontol. 2013 Jan; 15(1):2-7. PMID: 23413626.
      View in: PubMed
    26. Joo NE, Ritchie K, Kamarajan P, Miao D, Kapila Y. Nisin, an apoptogenic bacteriocin and food preservative, attenuates HNSCC tumorigenesis via CHAC1. Cancer Med. 2012 Dec; 1(3):295-305. PMID: 23342279; PMCID: PMC3544465.
    27. Tripathi P, Kamarajan P, Somashekar BS, MacKinnon N, Chinnaiyan AM, Kapila Y, Rajendiran TM, Ramamoorthy A. Delineating metabolic signatures of head and neck squamous cell carcinoma: phospholipase A2, a potential therapeutic target. Int J Biochem Cell Biol. 2012 Nov; 44(11):1852-61. PMID: 22743333; PMCID: PMC3455146.
    28. Kamarajan P, Alhazzazi TY, Danciu T, D'silva NJ, Verdin E, Kapila Y. Receptor-interacting protein (RIP) and Sirtuin-3 (SIRT3) are on opposite sides of anoikis and tumorigenesis. Cancer. 2012 Dec 01; 118(23):5800-10. PMID: 22674009; PMCID: PMC3443499.
    29. Somashekar BS, Kamarajan P, Danciu T, Kapila Y, Chinnaiyan AM, Rajendiran TM, Ramamoorthy A. Magic angle spinning NMR-based metabolic profiling of head and neck squamous cell carcinoma tissues. J Proteome Res. 2011 Nov 04; 10(11):5232-41. PMID: 21961579; PMCID: PMC3208743.
    30. Alhazzazi TY, Kamarajan P, Verdin E, Kapila Y. SIRT3 and cancer: tumor promoter or suppressor? Biochim Biophys Acta. 2011 Aug; 1816(1):80-8. PMID: 21586315; PMCID: PMC3129516.
    31. Hayami T, Kapila Y, Kapila S. Divergent upstream osteogenic events contribute to the differential modulation of MG63 cell osteoblast differentiation by MMP-1 (collagenase-1) and MMP-13 (collagenase-3). Matrix Biol. 2011 May; 30(4):281-9. PMID: 21539914; PMCID: PMC3116144.
    32. Marchesan JT, Scanlon CS, Soehren S, Matsuo M, Kapila Y. Implications of cultured periodontal ligament cells for the clinical and experimental setting: a review. Arch Oral Biol. 2011 Oct; 56(10):933-43. PMID: 21470594; PMCID: PMC3132241.
    33. Alhazzazi TY, Kamarajan P, Joo N, Huang JY, Verdin E, D'Silva NJ, Kapila Y. Sirtuin-3 (SIRT3), a novel potential therapeutic target for oral cancer. Cancer. 2011 Apr 15; 117(8):1670-8. PMID: 21472714; PMCID: PMC3117020.
    34. Miao D, Fenno JC, Timm JC, Joo NE, Kapila Y. The Treponema denticola chymotrypsin-like protease dentilisin induces matrix metalloproteinase-2-dependent fibronectin fragmentation in periodontal ligament cells. Infect Immun. 2011 Feb; 79(2):806-11. PMID: 21115719; PMCID: PMC3028863.
    35. Pirih FQ, Michalski MN, Cho SW, Koh AJ, Berry JE, Ghaname E, Kamarajan P, Bonnelye E, Ross CW, Kapila Y, Jurdic P, McCauley LK. Parathyroid hormone mediates hematopoietic cell expansion through interleukin-6. PLoS One. 2010 Oct 27; 5(10):e13657. PMID: 21048959; PMCID: PMC2965090.
    36. Ghosh A, Chen TC, Kapila Y. Anoikis triggers Mdm2-dependent p53 degradation. Mol Cell Biochem. 2010 Oct; 343(1-2):201-9. PMID: 20577896; PMCID: PMC2943547.
    37. Kamarajan P, Garcia-Pardo A, D'Silva NJ, Kapila Y. The CS1 segment of fibronectin is involved in human OSCC pathogenesis by mediating OSCC cell spreading, migration, and invasion. BMC Cancer. 2010 Jun 25; 10:330. PMID: 20579373; PMCID: PMC3146068.
    38. Paula-Silva FW, Ghosh A, Arzate H, Kapila S, da Silva LA, Kapila Y. Calcium hydroxide promotes cementogenesis and induces cementoblastic differentiation of mesenchymal periodontal ligament cells in a CEMP1- and ERK-dependent manner. Calcif Tissue Int. 2010 Aug; 87(2):144-57. PMID: 20440482.
      View in: PubMed
    39. Paula-Silva FW, da Silva LA, Kapila Y. Matrix metalloproteinase expression in teeth with apical periodontitis is differentially modulated by the modality of root canal treatment. J Endod. 2010 Feb; 36(2):231-7. PMID: 20113780; PMCID: PMC2818380.
    40. Joseph J, Kapila Y, Hayami T, Kapila S. Disease-associated extracellular matrix suppresses osteoblastic differentiation of human periodontal ligament cells via MMP-1. Calcif Tissue Int. 2010 Feb; 86(2):154-62. PMID: 19953231; PMCID: PMC3152822.
    41. Kamarajan P, Bunek J, Lin Y, Nunez G, Kapila Y. Receptor-interacting protein shuttles between cell death and survival signaling pathways. Mol Biol Cell. 2010 Feb 01; 21(3):481-8. PMID: 19955213; PMCID: PMC2814792.
    42. Daniels TE, Kapila Y. Comments on atrophic lingual papillae and candidiasis in Sjögren syndrome. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010 Jan; 109(1):4; author reply 4. PMID: 19828340.
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    43. de Paula-Silva FW, D'Silva NJ, da Silva LA, Kapila Y. High matrix metalloproteinase activity is a hallmark of periapical granulomas. J Endod. 2009 Sep; 35(9):1234-42. PMID: 19720222; PMCID: PMC2736957.
    44. Xu J, Wang W, Kapila Y, Lotz J, Kapila S. Multiple differentiation capacity of STRO-1+/CD146+ PDL mesenchymal progenitor cells. Stem Cells Dev. 2009 Apr; 18(3):487-96. PMID: 18593336; PMCID: PMC2702120.
    45. Ghosh A, Park JY, Fenno C, Kapila Y. Porphyromonas gingivalis, gamma interferon, and a proapoptotic fibronectin matrix form a synergistic trio that induces c-Jun N-terminal kinase 1-mediated nitric oxide generation and cell death. Infect Immun. 2008 Dec; 76(12):5514-23. PMID: 18838522; PMCID: PMC2583576.
    46. Hayami T, Kapila Y, Kapila S. MMP-1 (collagenase-1) and MMP-13 (collagenase-3) differentially regulate markers of osteoblastic differentiation in osteogenic cells. Matrix Biol. 2008 Oct; 27(8):682-92. PMID: 18755271; PMCID: PMC2683744.
    47. Kamarajan P, Kapila Y. An altered fibronectin matrix induces anoikis of human squamous cell carcinoma cells by suppressing integrin alpha v levels and phosphorylation of FAK and ERK. Apoptosis. 2007 Dec; 12(12):2221-31. PMID: 17879163.
      View in: PubMed
    48. Hayami T, Zhang Q, Kapila Y, Kapila S. Dexamethasone's enhancement of osteoblastic markers in human periodontal ligament cells is associated with inhibition of collagenase expression. Bone. 2007 Jan; 40(1):93-104. PMID: 16934542.
      View in: PubMed
    49. Tafolla E, Wang S, Wong B, Leong J, Kapila Y. JNK1 and JNK2 oppositely regulate p53 in signaling linked to apoptosis triggered by an altered fibronectin matrix: JNK links FAK and p53. J Biol Chem. 2005 May 20; 280(20):19992-9. PMID: 15778501.
      View in: PubMed
    50. Lu H, Jin D, Kapila Y. Application of laser capture microdissection to phage display peptide library screening. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2004 Dec; 98(6):692-7. PMID: 15583542.
      View in: PubMed
    51. Zhang Y, Lu H, Dazin P, Kapila Y. Squamous cell carcinoma cell aggregates escape suspension-induced, p53-mediated anoikis: fibronectin and integrin alphav mediate survival signals through focal adhesion kinase. J Biol Chem. 2004 Nov 12; 279(46):48342-9. PMID: 15331608.
      View in: PubMed
    52. Zhang Y, Lu H, Dazin P, Kapila Y. Functional differences between integrin alpha4 and integrins alpha5/alphav in modulating the motility of human oral squamous carcinoma cells in response to the V region and heparin-binding domain of fibronectin. Exp Cell Res. 2004 Apr 15; 295(1):48-58. PMID: 15051489.
      View in: PubMed
    53. Jee SW, Wang S, Kapila Y. Specific pro-apoptotic fibronectin fragments modulate proteinase expression in periodontal ligament cells. J Periodontol. 2004 Apr; 75(4):523-30. PMID: 15152815.
      View in: PubMed
    54. Shiga M, Kapila Y, Zhang Q, Hayami T, Kapila S. Ascorbic acid induces collagenase-1 in human periodontal ligament cells but not in MC3T3-E1 osteoblast-like cells: potential association between collagenase expression and changes in alkaline phosphatase phenotype. J Bone Miner Res. 2003 Jan; 18(1):67-77. PMID: 12510807.
      View in: PubMed
    55. Huynh QN, Wang S, Tafolla E, Gansky SA, Kapila S, Armitage GC, Kapila Y. Specific fibronectin fragments as markers of periodontal disease status. J Periodontol. 2002 Oct; 73(10):1101-10. PMID: 12416766.
      View in: PubMed
    56. Kapila Y, Wang S, Dazin P, Tafolla E, Mass MJ. The heparin-binding domain and V region of fibronectin regulate apoptosis by suppression of p53 and c-myc in human primary cells. J Biol Chem. 2002 Mar 08; 277(10):8482-91. PMID: 11751853.
      View in: PubMed
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