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Zena Vexler, PhD

TitleProfessor
SchoolUCSF School of Medicine
DepartmentNeurology
Address675 Nelson Rising Lane
San Francisco CA 94158
Phone415-502-2282
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    Zinaida Vexler, PhD, is Professor in the Department of Neurology at UCSF and Director of Research at the Neonatal Brain Disorder Center. She has multi-disciplinary training in chemistry, biochemistry, pharmacology, and physiology and has served as Director of MRI Core on PPG since 2002, and as the Director of Research of Neonatal Brain Disorders Center at UCSF since 2003.

    Over the last twenty years, her research has been centered on the mechanisms of experimental stroke with the long-term goal of developing effective therapies. She has contributed to the fields of brain vascular and cellular injury after experimental stroke first in the adult and, over more than seventeen years, in the neonate. Dr. Vexler’s lab was the first to establish and characterize the in vivo models of focal arterial stroke in neonatal rodents. With these age-appropriate models of perinatal stroke, she defined that the “signature” of neurovascular integrity after stroke is markedly different after neonatal stroke than after adult stroke. Her studies of microglial cell function in injured neonatal brain have been critical for the improved understanding of neuroinflammation as modifier of perinatal stroke.


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    Leukocyte trafficking through the choroid plexus as modulator of neonatal focal stroke
    NIH R21NS098514Jul 1, 2016 - Jun 30, 2018
    Role: Principal Investigator
    Macrophages as modulators of repair after neonatal stroke
    NIH R01NS076726Jul 1, 2012 - Jun 30, 2017
    Role: Principal Investigator
    Blood-brain barrier function after neonatal and pediatric experimental stroke
    NIH R21NS080015Jul 1, 2012 - Jun 30, 2014
    Role: Principal Investigator
    CINC-1 as a modulator of blood-brain barrier integrity after neonatal stroke
    NIH R01NS055915Aug 5, 2009 - Jul 31, 2012
    Role: Principal Investigator
    Neonatal Stroke: The Role of Microglia
    NIH R01NS044025Sep 1, 2002 - Feb 28, 2018
    Role: Principal Investigator
    Mechanisms of Ischemic Neonatal Brain Injury
    NIH/NINDS P50NS035902Apr 1, 1997 - Jan 31, 2014
    Role: Co-Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Fernández-López D, Faustino J, Klibanov AL, Derugin N, Blanchard E, Simon F, Leib SL, Vexler Z. Microglial Cells Prevent Hemorrhage in Neonatal Focal Arterial Stroke. J Neurosci. 2016 Mar 9; 36(10):2881-93. PMID: 26961944; PMCID: PMC4783493 [Available on 09/09/16].
    2. Li F, Faustino J, Woo MS, Derugin N, Vexler Z. Lack of the scavenger receptor CD36 alters microglial phenotypes after neonatal stroke. J Neurochem. 2015 Nov; 135(3):445-52. PMID: 26223273; PMCID: PMC4844456 [Available on 11/01/16].
    3. Mallard C, Vexler Z. Modeling Ischemia in the Immature Brain: How Translational Are Animal Models? Stroke. 2015 Oct; 46(10):3006-11. PMID: 26272384; PMCID: PMC4589478 [Available on 10/01/16].
    4. Sohet F, Lin C, Munji RN, Lee SY, Ruderisch N, Soung A, Arnold TD, Derugin N, Vexler Z, Yen FT, Daneman R. LSR/angulin-1 is a tricellular tight junction protein involved in blood-brain barrier formation. J Cell Biol. 2015 Mar 16; 208(6):703-11. PMID: 25753034; PMCID: PMC4362448.
    5. Hagberg H, Mallard C, Ferriero DM, Vannucci SJ, Levison SW, Vexler Z, Gressens P. The role of inflammation in perinatal brain injury. Nat Rev Neurol. 2015 Apr; 11(4):192-208. PMID: 25686754; PMCID: PMC4664161.
    6. Titomanlio L, Fernández-López D, Manganozzi L, Moretti R, Vexler Z, Gressens P. Pathophysiology and neuroprotection of global and focal perinatal brain injury: lessons from animal models. Pediatr Neurol. 2015 Jun; 52(6):566-84. PMID: 26002050; PMCID: PMC4720385.
    7. Kratzer I, Chip S, Vexler Z. Barrier mechanisms in neonatal stroke. Front Neurosci. 2014; 8:359. PMID: 25426016; PMCID: PMC4224076.
    8. van Velthoven CT, Gonzalez F, Vexler Z, Ferriero DM. Stem cells for neonatal stroke- the future is here. Front Cell Neurosci. 2014; 8:207. PMID: 25120432; PMCID: PMC4110439.
    9. Fernández-López D, Natarajan N, Ashwal S, Vexler Z. Mechanisms of perinatal arterial ischemic stroke. J Cereb Blood Flow Metab. 2014 Jun; 34(6):921-32. PMID: 24667913; PMCID: PMC4050239.
    10. Dzietko M, Derugin N, Wendland MF, Vexler Z, Ferriero DM. Delayed VEGF treatment enhances angiogenesis and recovery after neonatal focal rodent stroke. Transl Stroke Res. 2013 Apr; 4(2):189-200. PMID: 23926451; PMCID: PMC3733573.
    11. Fernández-López D, Faustino J, Derugin N, Vexler Z. Acute and chronic vascular responses to experimental focal arterial stroke in the neonate rat. Transl Stroke Res. 2013 Apr; 4(2):179-88. PMID: 23730350; PMCID: PMC3665524.
    12. van Velthoven CT, Sheldon RA, Kavelaars A, Derugin N, Vexler Z, Willemen HL, Maas M, Heijnen CJ, Ferriero DM. Mesenchymal stem cell transplantation attenuates brain injury after neonatal stroke. Stroke. 2013 May; 44(5):1426-32. PMID: 23539530; PMCID: PMC3694433.
    13. Woo MS, Wang X, Faustino JV, Derugin N, Wendland MF, Zhou P, Iadecola C, Vexler Z. Genetic deletion of CD36 enhances injury after acute neonatal stroke. Ann Neurol. 2012 Dec; 72(6):961-70. PMID: 23280844; PMCID: PMC3539222.
    14. Fernández-López D, Faustino J, Daneman R, Zhou L, Lee SY, Derugin N, Wendland MF, Vexler Z. Blood-brain barrier permeability is increased after acute adult stroke but not neonatal stroke in the rat. J Neurosci. 2012 Jul 11; 32(28):9588-600. PMID: 22787045; PMCID: PMC3539825.
    15. Fernández-López D, Faustino J, Derugin N, Wendland M, Lizasoain I, Moro MA, Vexler Z. Reduced infarct size and accumulation of microglia in rats treated with WIN 55,212-2 after neonatal stroke. Neuroscience. 2012 Apr 5; 207:307-15. PMID: 22285309; PMCID: PMC3446851.
    16. Faustino JV, Wang X, Johnson CE, Klibanov A, Derugin N, Wendland MF, Vexler Z. Microglial cells contribute to endogenous brain defenses after acute neonatal focal stroke. J Neurosci. 2011 Sep 7; 31(36):12992-3001. PMID: 21900578; PMCID: PMC3539822.
    17. Dzietko M, Wendland M, Derugin N, Ferriero DM, Vexler Z. Magnetic resonance imaging (MRI) as a translational tool for the study of neonatal stroke. J Child Neurol. 2011 Sep; 26(9):1145-53. PMID: 21670390; PMCID: PMC3695703.
    18. Shimotake J, Derugin N, Wendland M, Vexler Z, Ferriero DM. Vascular endothelial growth factor receptor-2 inhibition promotes cell death and limits endothelial cell proliferation in a neonatal rodent model of stroke. Stroke. 2010 Feb; 41(2):343-9. PMID: 20101028; PMCID: PMC2846555.
    19. Vexler Z, Yenari MA. Does inflammation after stroke affect the developing brain differently than adult brain? Dev Neurosci. 2009; 31(5):378-93. PMID: 19672067; PMCID: PMC2790734.
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