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Zena Werb, PhD

Title(s)Professor, Anatomy
SchoolSchool of Medicine
Address513 Parnassus Ave, HSW
San Francisco CA 94143
Phone415-476-4564
ORCID ORCID Icon0000-0002-6525-3872 Additional info
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    Collapse Biography 
    Collapse Education and Training
    University of Toronto (University College), , Toronto, CanadaHonors B.Sc.06/1966Biochemistry
    Rockefeller University, New York, NYPh.D.1971Cell Biology
    Strangeways Research Laboratory, Cambridge, UKPost-doc.08/1973Protein Chemistry
    Collapse Awards and Honors
    American Association for Cancer research2018Distinguished Lectureship in Breast Cancer Research Award
    Academy of the American Association for Cancer Research2019Fellow

    Collapse Research 
    Collapse Research Activities and Funding
    Integrative approach to heterogeneity in breast cancer metastasis
    NIH/NCI U01CA199315Jun 1, 2016 - May 31, 2021
    Role: Principal Investigator
    Role of GATA3 in transcriptional pathways suppressing breast cancer metastasis
    NIH/NCI R01CA190851Jul 1, 2015 - Jun 30, 2020
    Role: Principal Investigator
    (PQC4) Fate of cells disseminating from human breast cancer xenografts
    NIH/NCI R01CA180039Aug 1, 2013 - Jun 30, 2017
    Role: Principal Investigator
    Environmental Effect on the Mammary Gland across the Lifespan
    NIH/NIEHS U01ES019458Sep 1, 2010 - Apr 30, 2015
    Role: Principal Investigator
    Caliper Life Sciences Xenogen IVIS Imager
    NIH/NCRR S10RR026435Feb 18, 2010 - Feb 17, 2011
    Role: Principal Investigator
    Mucosal Immune Barrier in Infection and Immunity
    NIH/NIAID P01AI053194Sep 1, 2009 - Sep 24, 2008
    Role: Co-Investigator
    TRANSCRIPTIONAL REGULATION OF BREAST CANCER METASTASIS
    NIH/NCI R01CA129523Jul 1, 2008 - Sep 29, 2011
    Role: Principal Investigator
    Matrix Metalloproteinases Gordon Conference
    NIH/NCI R13CA115182Jun 1, 2005 - May 31, 2010
    Role: Co-Principal Investigator
    Molecular and Cellular Mechanisms in Cancer
    NIH/NCI T32CA108462Sep 1, 2004 - Aug 31, 2019
    Role: Principal Investigator
    Resource for X-ray Tomography of Whole Cells
    NIH/NCRR P41RR019664May 6, 2004 - Apr 30, 2013
    Role: Co-Investigator
    Perkin Elmer Ultraview Spinning Disc Confocal Microscope
    NIH/NCRR S10RR019401Apr 1, 2004 - Mar 31, 2006
    Role: Principal Investigator
    Smoke-induced AP-1 controls mucous vs squamous phenotype
    NIH/NHLBI R01HL075602Jan 20, 2004 - Dec 31, 2008
    Role: Principal Investigator
    Matrix Metalloproteases Regulate Mesenchymal Stem Cells
    NIH/NIA R01AG023218Jul 1, 2003 - Jun 30, 2007
    Role: Principal Investigator
    Gordon Research Conference on Matrix Metalloproteinases
    NIH/NIDCR R13DE015313Jun 1, 2003 - May 31, 2004
    Role: Principal Investigator
    Role of Chloride Channels in Mucin Production
    NIH/NHLBI R01HL073309Apr 1, 2003 - Mar 31, 2007
    Role: Principal Investigator
    Extracellular remodeling in bone development and repair
    NIH/NIAMS R01AR046238Sep 1, 1999 - Jan 31, 2011
    Role: Principal Investigator
    Proteases in Cancer Biology and Drug Development
    NIH/NCI P01CA072006Jun 1, 1998 - Nov 30, 2002
    Role: Principal Investigator
    CELLULAR AND MOLECULAR RESPONSES TO LOW DOSE RADIATION
    NIH/NCI R01CA075072Aug 15, 1997 - Nov 30, 2002
    Role: Principal Investigator
    Role of Metalloproteinases in Mammary Gland Remodeling
    NIH/NCI R01CA057621Apr 15, 1993 - Sep 29, 2013
    Role: Principal Investigator
    ADHESION AND REMODELING MECHANISMS IN GINGIVA AND BONE
    NIH/NIDCR P50DE010306Dec 1, 1992 - Oct 31, 1999
    Role: Co-Investigator
    DEVELOPMENTAL BIOLOGY OF THE IMPLANTING MAMMALIAN EMBRYO
    NIH/NICHD P01HD026732Feb 1, 1991 - Jan 31, 2002
    Role: Co-Investigator
    METALLOPROTEINASES IN PERI-IMPLANTATION DEVELOPMENT
    NIH/NICHD R01HD023539Feb 1, 1988 - Jan 31, 1994
    Role: Principal Investigator
    MULTIPURPOSE ARTHRITIS AND MUSCULOSKELETAL DISEASES CTR
    NIH/NIAMS P60AR020684Apr 1, 1986 - Dec 31, 2003
    Role: Co-Investigator
    ENVIRONMENTAL MUTAGENESIS AND CARCINOGENESIS
    NIH/NIEHS T32ES007106Jul 1, 1982 - Jun 30, 2003
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Global Health
    Collapse In The News
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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. LGR5 in breast cancer and ductal carcinoma in situ: a diagnostic and prognostic biomarker and a therapeutic target. BMC Cancer. 2020 Jun 10; 20(1):542. Hagerling C, Owyong M, Sitarama V, Wang CY, Lin C, van den Bijgaart RJE, Koopman CD, Brenot A, Nanjaraj A, Wärnberg F, Jirström K, Klein OD, Werb Z, Plaks V. PMID: 32522170.
      View in: PubMed   Mentions:    Fields:    
    2. Transcriptional diversity and bioenergetic shift in human breast cancer metastasis revealed by single-cell RNA sequencing. Nat Cell Biol. 2020 03; 22(3):310-320. Davis RT, Blake K, Ma D, Gabra MBI, Hernandez GA, Phung AT, Yang Y, Maurer D, Lefebvre AEYT, Alshetaiwi H, Xiao Z, Liu J, Locasale JW, Digman MA, Mjolsness E, Kong M, Werb Z, Lawson DA. PMID: 32144411.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    3. Autophagic Degradation of NBR1 Restricts Metastatic Outgrowth during Mammary Tumor Progression. Dev Cell. 2020 Mar 09; 52(5):591-604.e6. Marsh T, Kenific CM, Suresh D, Gonzalez H, Shamir ER, Mei W, Tankka A, Leidal AM, Kalavacherla S, Woo K, Werb Z, Debnath J. PMID: 32084360.
      View in: PubMed   Mentions:    Fields:    
    4. A framework for advancing our understanding of cancer-associated fibroblasts. Nat Rev Cancer. 2020 03; 20(3):174-186. Sahai E, Astsaturov I, Cukierman E, DeNardo DG, Egeblad M, Evans RM, Fearon D, Greten FR, Hingorani SR, Hunter T, Hynes RO, Jain RK, Janowitz T, Jorgensen C, Kimmelman AC, Kolonin MG, Maki RG, Powers RS, Puré E, Ramirez DC, Scherz-Shouval R, Sherman MH, Stewart S, Tlsty TD, Tuveson DA, Watt FM, Weaver V, Weeraratna AT, Werb Z. PMID: 31980749.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    5. MMP9 modulates the metastatic cascade and immune landscape for breast cancer anti-metastatic therapy. Life Sci Alliance. 2019 12; 2(6). Owyong M, Chou J, van den Bijgaart RJ, Kong N, Efe G, Maynard C, Talmi-Frank D, Solomonov I, Koopman C, Hadler-Olsen E, Headley M, Lin C, Wang CY, Sagi I, Werb Z, Plaks V. PMID: 31727800.
      View in: PubMed   Mentions: 3     Fields:    
    6. Immune effector monocyte-neutrophil cooperation induced by the primary tumor prevents metastatic progression of breast cancer. Proc Natl Acad Sci U S A. 2019 10 22; 116(43):21704-21714. Hagerling C, Gonzalez H, Salari K, Wang CY, Lin C, Robles I, van Gogh M, Dejmek A, Jirström K, Werb Z. PMID: 31591235.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    7. MULTI-seq: sample multiplexing for single-cell RNA sequencing using lipid-tagged indices. Nat Methods. 2019 07; 16(7):619-626. McGinnis CS, Patterson DM, Winkler J, Conrad DN, Hein MY, Srivastava V, Hu JL, Murrow LM, Weissman JS, Werb Z, Chow ED, Gartner ZJ. PMID: 31209384.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    8. Tumour heterogeneity and metastasis at single-cell resolution. Nat Cell Biol. 2018 12; 20(12):1349-1360. Lawson DA, Kessenbrock K, Davis RT, Pervolarakis N, Werb Z. PMID: 30482943.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    9. Complement C5a Fosters Squamous Carcinogenesis and Limits T Cell Response to Chemotherapy. Cancer Cell. 2018 10 08; 34(4):561-578.e6. Medler TR, Murugan D, Horton W, Kumar S, Cotechini T, Forsyth AM, Leyshock P, Leitenberger JJ, Kulesz-Martin M, Margolin AA, Werb Z, Coussens LM. PMID: 30300579.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    10. Roles of the immune system in cancer: from tumor initiation to metastatic progression. Genes Dev. 2018 10 01; 32(19-20):1267-1284. Gonzalez H, Hagerling C, Werb Z. PMID: 30275043.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    11. Profiling human breast epithelial cells using single cell RNA sequencing identifies cell diversity. Nat Commun. 2018 05 23; 9(1):2028. Nguyen QH, Pervolarakis N, Blake K, Ma D, Davis RT, James N, Phung AT, Willey E, Kumar R, Jabart E, Driver I, Rock J, Goga A, Khan SA, Lawson DA, Werb Z, Kessenbrock K. PMID: 29795293.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    12. Discoidin domain receptor 1 (DDR1) ablation promotes tissue fibrosis and hypoxia to induce aggressive basal-like breast cancers. Genes Dev. 2018 02 01; 32(3-4):244-257. Takai K, Drain AP, Lawson DA, Littlepage LE, Karpuj M, Kessenbrock K, Le A, Inoue K, Weaver VM, Werb Z. PMID: 29483153.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    13. HIF signaling in osteoblast-lineage cells promotes systemic breast cancer growth and metastasis in mice. Proc Natl Acad Sci U S A. 2018 01 30; 115(5):E992-E1001. Devignes CS, Aslan Y, Brenot A, Devillers A, Schepers K, Fabre S, Chou J, Casbon AJ, Werb Z, Provot S. PMID: 29339479.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    14. Single-cell RNA sequencing reveals gene expression signatures of breast cancer-associated endothelial cells. Oncotarget. 2018 Feb 16; 9(13):10945-10961. Sun Z, Wang CY, Lawson DA, Kwek S, Velozo HG, Owyong M, Lai MD, Fong L, Wilson M, Su H, Werb Z, Cooke DL. PMID: 29541388.
      View in: PubMed   Mentions: 1     Fields:    
    15. Innate and acquired immune surveillance in the postdissemination phase of metastasis. FEBS J. 2018 02; 285(4):654-664. Gonzalez H, Robles I, Werb Z. PMID: 29131550.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    16. Endovascular Biopsy: In Vivo Cerebral Aneurysm Endothelial Cell Sampling and Gene Expression Analysis. Transl Stroke Res. 2018 02; 9(1):20-33. Cooke DL, McCoy DB, Halbach VV, Hetts SW, Amans MR, Dowd CF, Higashida RT, Lawson D, Nelson J, Wang CY, Kim H, Werb Z, McCulloch C, Hashimoto T, Su H, Sun Z. PMID: 28900857.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    17. GATA3 targets semaphorin 3B in mammary epithelial cells to suppress breast cancer progression and metastasis. Oncogene. 2017 10 05; 36(40):5567-5575. Shahi P, Wang CY, Chou J, Hagerling C, Gonzalez Velozo H, Ruderisch A, Yu Y, Lai MD, Werb Z. PMID: 28581515.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    18. Diverse regulation of mammary epithelial growth and branching morphogenesis through noncanonical Wnt signaling. Proc Natl Acad Sci U S A. 2017 03 21; 114(12):3121-3126. Kessenbrock K, Smith P, Steenbeek SC, Pervolarakis N, Kumar R, Minami Y, Goga A, Hinck L, Werb Z. PMID: 28270600.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    19. ZNF503/Zpo2 drives aggressive breast cancer progression by down-regulation of GATA3 expression. Proc Natl Acad Sci U S A. 2017 03 21; 114(12):3169-3174. Shahi P, Wang CY, Lawson DA, Slorach EM, Lu A, Yu Y, Lai MD, Gonzalez Velozo H, Werb Z. PMID: 28258171.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    20. Targeting the cancer-associated fibroblasts as a treatment in triple-negative breast cancer. Oncotarget. 2016 Dec 13; 7(50):82889-82901. Takai K, Le A, Weaver VM, Werb Z. PMID: 27756881.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    21. Systematic analysis of the achaete-scute complex-like gene signature in clinical cancer patients. Mol Clin Oncol. 2017 Jan; 6(1):7-18. Wang CY, Shahi P, Huang JT, Phan NN, Sun Z, Lin YC, Lai MD, Werb Z. PMID: 28123722.
      View in: PubMed   Mentions:
    22. PIM1 kinase inhibition as a targeted therapy against triple-negative breast tumors with elevated MYC expression. Nat Med. 2016 11; 22(11):1321-1329. Horiuchi D, Camarda R, Zhou AY, Yau C, Momcilovic O, Balakrishnan S, Corella AN, Eyob H, Kessenbrock K, Lawson DA, Marsh LA, Anderton BN, Rohrberg J, Kunder R, Bazarov AV, Yaswen P, McManus MT, Rugo HS, Werb Z, Goga A. PMID: 27775705.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    23. Cancer-associated fibroblast-secreted CXCL16 attracts monocytes to promote stroma activation in triple-negative breast cancers. Nat Commun. 2016 10 11; 7:13050. Allaoui R, Bergenfelz C, Mohlin S, Hagerling C, Salari K, Werb Z, Anderson RL, Ethier SP, Jirström K, Påhlman S, Bexell D, Tahin B, Johansson ME, Larsson C, Leandersson K. PMID: 27725631.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    24. SPRY1 regulates mammary epithelial morphogenesis by modulating EGFR-dependent stromal paracrine signaling and ECM remodeling. Proc Natl Acad Sci U S A. 2016 09 27; 113(39):E5731-40. Koledova Z, Zhang X, Streuli C, Clarke RB, Klein OD, Werb Z, Lu P. PMID: 27621461.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    25. Deficiency in matrix metalloproteinase-2 results in long-term vascular instability and regression in the injured mouse spinal cord. Exp Neurol. 2016 Oct; 284(Pt A):50-62. Trivedi A, Zhang H, Ekeledo A, Lee S, Werb Z, Plant GW, Noble-Haeusslein LJ. PMID: 27468657.
      View in: PubMed   Mentions: 3     Fields:    
    26. Metalloproteinases: a Functional Pathway for Myeloid Cells. Microbiol Spectr. 2016 04; 4(2). Chou J, Chan MF, Werb Z. PMID: 27227311.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    27. Neutrophils: Critical components in experimental animal models of cancer. Semin Immunol. 2016 04; 28(2):197-204. Hagerling C, Werb Z. PMID: 26976824.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    28. Quantitative proteomic analyses of mammary organoids reveals distinct signatures after exposure to environmental chemicals. Proc Natl Acad Sci U S A. 2016 Mar 08; 113(10):E1343-51. Williams KE, Lemieux GA, Hassis ME, Olshen AB, Fisher SJ, Werb Z. PMID: 26903627.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    29. The Cleared Mammary Fat Pad Transplantation Assay for Mammary Epithelial Organogenesis. Cold Spring Harb Protoc. 2015 Dec 02; 2015(12):pdb.prot078071. Lawson DA, Werb Z, Zong Y, Goldstein AS. PMID: 26631119.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    30. p114RhoGEF governs cell motility and lumen formation during tubulogenesis through a ROCK-myosin-II pathway. J Cell Sci. 2015 Dec 01; 128(23):4317-27. Kim M, M Shewan A, Ewald AJ, Werb Z, Mostov KE. PMID: 26483385.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    31. Single-cell analysis reveals a stem-cell program in human metastatic breast cancer cells. Nature. 2015 Oct 01; 526(7571):131-5. Lawson DA, Bhakta NR, Kessenbrock K, Prummel KD, Yu Y, Takai K, Zhou A, Eyob H, Balakrishnan S, Wang CY, Yaswen P, Goga A, Werb Z. PMID: 26416748.
      View in: PubMed   Mentions: 153     Fields:    Translation:HumansAnimalsCells
    32. Adaptive Immune Regulation of Mammary Postnatal Organogenesis. Dev Cell. 2015 Sep 14; 34(5):493-504. Plaks V, Boldajipour B, Linnemann JR, Nguyen NH, Kersten K, Wolf Y, Casbon AJ, Kong N, van den Bijgaart RJ, Sheppard D, Melton AC, Krummel MF, Werb Z. PMID: 26321127.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    33. Endovascular biopsy: Strategy for analyzing gene expression profiles of individual endothelial cells obtained from human vessels?. Biotechnol Rep (Amst). 2015 Sep; 7:157-165. Sun Z, Lawson DA, Sinclair E, Wang CY, Lai MD, Hetts SW, Higashida RT, Dowd CF, Halbach VV, Werb Z, Su H, Cooke DL. PMID: 26989654.
      View in: PubMed   Mentions:
    34. Animal Models of Corneal Injury. Bio Protoc. 2015 Jul 05; 5(13):e1516. Chan MF, Werb Z. PMID: 26191536.
      View in: PubMed   Mentions:
    35. Confocal Imaging of Myeloid Cells in the Corneal Stroma of Live Mice. Bio Protoc. 2015 Jul 05; 5(13):e1517. Chan MF, Werb Z. PMID: 26191537.
      View in: PubMed   Mentions:
    36. The Role of Stroma in Tumor Development. Cancer J. 2015 Jul-Aug; 21(4):250-3. Werb Z, Lu P. PMID: 26222075.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    37. RasGRP1 opposes proliferative EGFR-SOS1-Ras signals and restricts intestinal epithelial cell growth. Nat Cell Biol. 2015 Jun; 17(6):804-15. Depeille P, Henricks LM, van de Ven RA, Lemmens E, Wang CY, Matli M, Werb Z, Haigis KM, Donner D, Warren R, Roose JP. PMID: 26005835.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    38. Invasion and metastasis--recent advances and future challenges. J Mol Med (Berl). 2015 Apr; 93(4):361-8. Chambers AF, Werb Z. PMID: 25772709.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    39. The cancer stem cell niche: how essential is the niche in regulating stemness of tumor cells? Cell Stem Cell. 2015 Mar 05; 16(3):225-38. Plaks V, Kong N, Werb Z. PMID: 25748930.
      View in: PubMed   Mentions: 193     Fields:    Translation:HumansAnimalsCells
    40. Delineating CSF-1-dependent regulation of myeloid cell diversity in tumors. Oncoimmunology. 2015 Jun; 4(6):e1008871. Casbon AJ, Lohela M, Werb Z. PMID: 26155427.
      View in: PubMed   Mentions:
    41. Matrix metalloproteinases in stem cell regulation and cancer. Matrix Biol. 2015 May-Jul; 44-46:184-90. Kessenbrock K, Wang CY, Werb Z. PMID: 25661772.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    42. Invasive breast cancer reprograms early myeloid differentiation in the bone marrow to generate immunosuppressive neutrophils. Proc Natl Acad Sci U S A. 2015 Feb 10; 112(6):E566-75. Casbon AJ, Reynaud D, Park C, Khuc E, Gan DD, Schepers K, Passegué E, Werb Z. PMID: 25624500.
      View in: PubMed   Mentions: 66     Fields:    Translation:AnimalsCells
    43. Kynurenic acid is a nutritional cue that enables behavioral plasticity. Cell. 2015 Jan 15; 160(1-2):119-31. Lemieux GA, Cunningham KA, Lin L, Mayer F, Werb Z, Ashrafi K. PMID: 25594177.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    44. The Transcriptional Repressor ZNF503/Zeppo2 Promotes Mammary Epithelial Cell Proliferation and Enhances Cell Invasion. J Biol Chem. 2015 Feb 06; 290(6):3803-13. Shahi P, Slorach EM, Wang CY, Chou J, Lu A, Ruderisch A, Werb Z. PMID: 25538248.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    45. Remodelling the extracellular matrix in development and disease. Nat Rev Mol Cell Biol. 2014 Dec; 15(12):786-801. Bonnans C, Chou J, Werb Z. PMID: 25415508.
      View in: PubMed   Mentions: 399     Fields:    Translation:HumansAnimalsCells
    46. Balancing the innate immune system in tumor development. Trends Cell Biol. 2015 Apr; 25(4):214-20. Hagerling C, Casbon AJ, Werb Z. PMID: 25444276.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    47. Intravital imaging reveals distinct responses of depleting dynamic tumor-associated macrophage and dendritic cell subpopulations. Proc Natl Acad Sci U S A. 2014 Nov 25; 111(47):E5086-95. Lohela M, Casbon AJ, Olow A, Bonham L, Branstetter D, Weng N, Smith J, Werb Z. PMID: 25385645.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    48. A molecular switch for the orientation of epithelial cell polarization. Dev Cell. 2014 Oct 27; 31(2):171-87. Bryant DM, Roignot J, Datta A, Overeem AW, Kim M, Yu W, Peng X, Eastburn DJ, Ewald AJ, Werb Z, Mostov KE. PMID: 25307480.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCells
    49. Real-time imaging of myeloid cells dynamics in ApcMin/+ intestinal tumors by spinning disk confocal microscopy. J Vis Exp. 2014 Oct 06; (92):51916. Bonnans C, Lohela M, Werb Z. PMID: 25350573.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    50. A multilevel model of postmenopausal breast cancer incidence. Cancer Epidemiol Biomarkers Prev. 2014 Oct; 23(10):2078-92. Hiatt RA, Porco TC, Liu F, Balke K, Balmain A, Barlow J, Braithwaite D, Diez-Roux AV, Kushi LH, Moasser MM, Werb Z, Windham GC, Rehkopf DH. PMID: 25017248.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    51. Efficacy of a metalloproteinase inhibitor in spinal cord injured dogs. PLoS One. 2014; 9(5):e96408. Levine JM, Cohen ND, Heller M, Fajt VR, Levine GJ, Kerwin SC, Trivedi AA, Fandel TM, Werb Z, Modestino A, Noble-Haeusslein LJ. PMID: 24788791.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    52. Collective invasion in breast cancer requires a conserved basal epithelial program. Cell. 2013 Dec 19; 155(7):1639-51. Cheung KJ, Gabrielson E, Werb Z, Ewald AJ. PMID: 24332913.
      View in: PubMed   Mentions: 169     Fields:    Translation:HumansAnimalsCells
    53. In silico molecular comparisons of C. elegans and mammalian pharmacology identify distinct targets that regulate feeding. PLoS Biol. 2013 Nov; 11(11):e1001712. Lemieux GA, Keiser MJ, Sassano MF, Laggner C, Mayer F, Bainton RJ, Werb Z, Roth BL, Shoichet BK, Ashrafi K. PMID: 24260022.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    54. Cancer. Circulating tumor cells. Science. 2013 Sep 13; 341(6151):1186-8. Plaks V, Koopman CD, Werb Z. PMID: 24031008.
      View in: PubMed   Mentions: 105     Fields:    Translation:HumansAnimalsCells
    55. Roadblocks to translational advances on metastasis research. Nat Med. 2013 Sep; 19(9):1104-9. Brabletz T, Lyden D, Steeg PS, Werb Z. PMID: 24013756.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    56. microRNA-mediated regulation of the tumor microenvironment. Cell Cycle. 2013 Oct 15; 12(20):3262-71. Chou J, Shahi P, Werb Z. PMID: 24036551.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansCells
    57. A role for matrix metalloproteinases in regulating mammary stem cell function via the Wnt signaling pathway. Cell Stem Cell. 2013 Sep 05; 13(3):300-13. Kessenbrock K, Dijkgraaf GJ, Lawson DA, Littlepage LE, Shahi P, Pieper U, Werb Z. PMID: 23871604.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    58. Protective effects of matrix metalloproteinase-12 following corneal injury. J Cell Sci. 2013 Sep 01; 126(Pt 17):3948-60. Chan MF, Li J, Bertrand A, Casbon AJ, Lin JH, Maltseva I, Werb Z. PMID: 23813962.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    59. Matrix metalloproteinase-9 deficiency phenocopies features of preeclampsia and intrauterine growth restriction. Proc Natl Acad Sci U S A. 2013 Jul 02; 110(27):11109-14. Plaks V, Rinkenberger J, Dai J, Flannery M, Sund M, Kanasaki K, Ni W, Kalluri R, Werb Z. PMID: 23776237.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimals
    60. Molecular determinants of lung development. Ann Am Thorac Soc. 2013 Apr; 10(2):S12-6. Morrisey EE, Cardoso WV, Lane RH, Rabinovitch M, Abman SH, Ai X, Albertine KH, Bland RD, Chapman HA, Checkley W, Epstein JA, Kintner CR, Kumar M, Minoo P, Mariani TJ, McDonald DM, Mukouyama YS, Prince LS, Reese J, Rossant J, Shi W, Sun X, Werb Z, Whitsett JA, Gail D, Blaisdell CJ, Lin QS. PMID: 23607856.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
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    392. Degradation of connective tissue matrices by macrophages. III. Morphological and biochemical studies on extracellular, pericellular, and intracellular events in matrix proteolysis by macrophages in culture. J Exp Med. 1980 Dec 01; 152(6):1537-53. Werb Z, Bainton DF, Jones PA. PMID: 7005386.
      View in: PubMed   Mentions: 25     Fields:    Translation:Cells
    393. Limited proteolysis by macrophage elastase inactivates human alpha 1-proteinase inhibitor. J Exp Med. 1980 Dec 01; 152(6):1563-70. Banda MJ, Clark EJ, Werb Z. PMID: 6969773.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    394. Degradation of connective tissue matrices by macrophages. II. Influence of matrix composition on proteolysis of glycoproteins, elastin, and collagen by macrophages in culture. J Exp Med. 1980 Dec 01; 152(6):1527-36. Jones PA, Werb Z. PMID: 6450258.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    395. Degradation of connective tissue matrices by macrophages. I. Proteolysis of elastin, glycoproteins, and collagen by proteinases isolated from macrophages. J Exp Med. 1980 Nov 01; 152(5):1340-57. Werb Z, Banda MJ, Jones PA. PMID: 7000966.
      View in: PubMed   Mentions: 60     Fields:    Translation:AnimalsCells
    396. Glucocorticoid receptors and glucocorticoid-sensitive secretion of neutral proteinases in a macrophage line. J Immunol. 1978 Jul; 121(1):115-21. Werb Z, Foley R, Munck A. PMID: 209106.
      View in: PubMed   Mentions: 16     Fields:    Translation:Cells
    397. Biochemical actions of glucocorticoids on macrophages in culture. Specific inhibition of elastase, collagenase, and plasminogen activator secretion and effects on other metabolic functions. J Exp Med. 1978 Jun 01; 147(6):1695-1712. Werb Z. PMID: 210248.
      View in: PubMed   Mentions: 52     Fields:    Translation:AnimalsCells
    398. Interaction of glucocorticoids with macrophages. Identification of glucocorticoid receptors in monocytes and macrophages. J Exp Med. 1978 Jun 01; 147(6):1684-94. Werb Z, Foley R, Munck A. PMID: 681878.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    399. Proteases induce secretion of collagenase and plasminogen activator by fibroblasts. Proc Natl Acad Sci U S A. 1978 Apr; 75(4):1839-43. Werb Z, Aggeler J. PMID: 205872.
      View in: PubMed   Mentions: 21     Fields:    Translation:Cells
    400. Cellular control of collagen breakdown in rheumatoid arthritis. Agents Actions. 1978 Jan; 8(1-2):36-42. Harris ED, Vater CA, Mainardi CL, Werb Z. PMID: 205120.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    401. Proliferative synovitis in hemophilia: biochemical and morphologic observations. Arthritis Rheum. 1978 Jan-Feb; 21(1):137-44. Mainardi CL, Levine PH, Werb Z, Harris ED. PMID: 623683.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    402. Evidence that species specificity and rate of collagen degradation are properties of collagen, not collagenase. Biochim Biophys Acta. 1977 Sep 27; 494(1):198-208. Burleigh MC, Werb Z, Reynolds JJ. PMID: 198007.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    403. Endogenous activation of latent collagenase by rheumatoid synovial cells. Evidence for a role of plasminogen activator. N Engl J Med. 1977 05 05; 296(18):1017-23. Werb Z, Mainardi CL, Vater CA, Harris ED. PMID: 66627.
      View in: PubMed   Mentions: 127     Fields:    Translation:HumansCells
    404. Secretion of macrophage neutral proteinase is enhanced by colchicine. Proc Natl Acad Sci U S A. 1976 Mar; 73(3):872-6. Gordon S, Werb Z. PMID: 176659.
      View in: PubMed   Mentions: 23     Fields:    Translation:Cells
    405. Lysosomes as modulators of cellular functions. Influence on the synthesis and secretion of non-lysosomal materials. Front Biol. 1976; 45:127-56. Werb Z, Dingle JT. PMID: 185097.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    406. Rabbit collagenase. Immunological identity of the enzymes released from cells and tissues in normal and pathological conditions. Biochem J. 1975 Dec; 151(3):665-69. Werb Z, Reynolds JJ. PMID: 56176.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    407. Immunochemical studies with a specific antiserum to rabbit fibroblast collagenase. Biochem J. 1975 Dec; 151(3):655-63. Werb Z, Reynolds JJ. PMID: 175786.
      View in: PubMed   Mentions: 7     Fields:    
    408. Purification and properties of a specific collagenase from rabbit synovial fibroblasts. Biochem J. 1975 Dec; 151(3):645-53. Werb Z, Reynolds JJ. PMID: 175785.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    409. Cytochalasin B increases collagenase production by cells in vitro. Nature. 1975 Sep 18; 257(5523):243-4. Harris ED, Reynolds JJ, Werb Z. PMID: 169478.
      View in: PubMed   Mentions: 17     Fields:    Translation:Cells
    410. Collagenase and other proteinases in the cornea of the retinol-deficient rat. Br J Nutr. 1975 Sep; 34(2):297-309. Pirie A, Werb Z, Burleigh MC. PMID: 169877.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    411. Elastase secretion by stimulated macrophages. Characterization and regulation. J Exp Med. 1975 Aug 01; 142(2):361-77. Werb Z, Gordon S. PMID: 167096.
      View in: PubMed   Mentions: 127     Fields:    Translation:AnimalsCells
    412. Secretion of a specific collagenase by stimulated macrophages. J Exp Med. 1975 Aug 01; 142(2):346-60. Werb Z, Gordon S. PMID: 167095.
      View in: PubMed   Mentions: 119     Fields:    Translation:AnimalsCells
    413. Stimulation by endocytosis of the secretion of collagenase and neutral proteinase from rabbit synovial fibroblasts. J Exp Med. 1974 Dec 01; 140(6):1482-97. Werb Z, Reynolds JJ. PMID: 4372292.
      View in: PubMed   Mentions: 50     Fields:    Translation:AnimalsCells
    414. The interaction of alpha2-macroglobulin with proteinases. Binding and inhibition of mammalian collagenases and other metal proteinases. Biochem J. 1974 May; 139(2):359-68. Werb Z, Burleigh MC, Barrett AJ, Starkey PM. PMID: 4374931.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    415. A specific collagenase from rabbit fibroblasts in monolayer culture. Biochem J. 1974 Feb; 137(2):373-85. Werb Z, Burleigh MC. PMID: 4363113.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    416. The preparation of macrophage lysosomes and phagolysosomes. Methods Enzymol. 1974; 31:339-45. Werb Z, Cohn ZA. PMID: 4608929.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    417. Plasma membrane synthesis in the macrophage following phagocytosis of polystyrene latex particles. J Biol Chem. 1972 Apr 25; 247(8):2439-46. Werb Z, Cohn ZA. PMID: 5019957.
      View in: PubMed   Mentions: 66     Fields:    Translation:AnimalsCells
    418. Cholesterol metabolism in the macrophage. 3. Ingestion and intracellular fate of cholesterol and cholesterol esters. J Exp Med. 1972 Jan; 135(1):21-44. Werb Z, Cohn ZA. PMID: 4550608.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    419. Cholesterol metabolism in the macrophage. I. The regulation of cholesterol exchange. J Exp Med. 1971 Dec 01; 134(6):1545-69. Werb Z, Cohn ZA. PMID: 5126640.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    420. Cholesterol metabolism in the macrophage. II. Alteration of subcellular exchangeable cholesterol compartments and exchange in other cell types. J Exp Med. 1971 Dec 01; 134(6):1570-90. Werb Z, Cohn ZA. PMID: 4942408.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
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