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Zena Werb, PhD

TitleProfessor
InstitutionUniversity of California San Francisco
DepartmentAnatomy
Address513 Parnassus Ave
San Francisco CA 94143
Phone415-476-4622
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    Collapse Biography 
    Collapse Education and Training
    University of Toronto (University College), , Toronto, CanadaHonors B.Sc.06/1966Biochemistry
    Rockefeller University, New York, NYPh.D.1971Cell Biology
    Strangeways Research Laboratory, Cambridge, UKPost-doc.08/1973Protein Chemistry

    Collapse Research 
    Collapse Research Activities and Funding
    Integrative approach to heterogeneity in breast cancer metastasis
    NIH/NCI U01CA199315Jun 1, 2016 - May 31, 2021
    Role: Principal Investigator
    Role of GATA3 in transcriptional pathways suppressing breast cancer metastasis
    NIH/NCI R01CA190851Jul 1, 2015 - Jun 30, 2020
    Role: Principal Investigator
    (PQC4) Fate of cells disseminating from human breast cancer xenografts
    NIH/NCI R01CA180039Aug 1, 2013 - Jun 30, 2017
    Role: Principal Investigator
    Environmental Effect on the Mammary Gland across the Lifespan
    NIH/NIEHS U01ES019458Sep 1, 2010 - Apr 30, 2015
    Role: Principal Investigator
    Caliper Life Sciences Xenogen IVIS Imager
    NIH/NCRR S10RR026435Feb 18, 2010 - Feb 17, 2011
    Role: Principal Investigator
    TRANSCRIPTIONAL REGULATION OF BREAST CANCER METASTASIS
    NIH/NCI R01CA129523Jul 1, 2008 - Apr 30, 2014
    Role: Principal Investigator
    Matrix Metalloproteinases Gordon Conference
    NIH/NCI R13CA115182Jun 1, 2005 - May 31, 2010
    Role: Co-Principal Investigator
    Molecular and Cellular Mechanisms in Cancer
    NIH/NCI T32CA108462Sep 1, 2004 - Aug 31, 2019
    Role: Principal Investigator
    Resource for X-ray Tomography of Whole Cells
    NIH/NCRR P41RR019664May 6, 2004 - Apr 30, 2013
    Role: Co-Investigator
    Perkin Elmer Ultraview Spinning Disc Confocal Microscope
    NIH/NCRR S10RR019401Apr 1, 2004 - Mar 31, 2006
    Role: Principal Investigator
    Smoke-induced AP-1 controls mucous vs squamous phenotype
    NIH/NHLBI R01HL075602Jan 20, 2004 - Dec 31, 2008
    Role: Principal Investigator
    Matrix Metalloproteases Regulate Mesenchymal Stem Cells
    NIH/NIA R01AG023218Jul 1, 2003 - Jun 30, 2007
    Role: Principal Investigator
    Gordon Research Conference on Matrix Metalloproteinases
    NIH/NIDCR R13DE015313Jun 1, 2003 - May 31, 2004
    Role: Principal Investigator
    Role of Chloride Channels in Mucin Production
    NIH/NHLBI R01HL073309Apr 1, 2003 - Mar 31, 2007
    Role: Principal Investigator
    Mucosal Immune Barrier in Infection and Immunity
    NIH/NIAID P01AI053194Sep 30, 2002 - Aug 31, 2014
    Role: Co-Investigator
    Extracellular remodeling in bone development and repair
    NIH/NIAMS R01AR046238Sep 1, 1999 - Jan 31, 2011
    Role: Principal Investigator
    CELLULAR AND MOLECULAR RESPONSES TO LOW DOSE RADIATION
    NIH/NCI R01CA075072Aug 15, 1997 - Nov 30, 2002
    Role: Principal Investigator
    Proteases in Cancer Biology and Drug Development
    NIH/NCI P01CA072006Jun 10, 1997 - Jun 30, 2010
    Role: Principal Investigator
    Role of Metalloproteinases in Mammary Gland Remodeling
    NIH/NCI R01CA057621Apr 15, 1993 - Aug 31, 2018
    Role: Principal Investigator
    ADHESION AND REMODELING MECHANISMS IN GINGIVA AND BONE
    NIH/NIDCR P50DE010306Dec 1, 1992 - Oct 31, 1999
    Role: Co-Investigator
    DEVELOPMENTAL BIOLOGY OF THE IMPLANTING MAMMALIAN EMBRYO
    NIH/NICHD P01HD026732Feb 1, 1991 - Jan 31, 2002
    Role: Co-Investigator
    METALLOPROTEINASES IN PERI-IMPLANTATION DEVELOPMENT
    NIH/NICHD R01HD023539Feb 1, 1988 - Jan 31, 1994
    Role: Principal Investigator
    ENVIRONMENTAL MUTAGENESIS AND CARCINOGENESIS
    NIH/NIEHS T32ES007106Jul 1, 1982 - Jun 30, 2003
    Role: Principal Investigator
    MULTIPURPOSE ARTHRITIS AND MUSCULOSKELETAL DISEASES CTR
    NIH/NIAMS P60AR020684Sep 15, 1977 - Dec 31, 2003
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Global Health
    Collapse Websites
    Collapse In The News
    Collapse Featured Videos

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Nguyen QH, Pervolarakis N, Blake K, Ma D, Davis RT, James N, Phung AT, Willey E, Kumar R, Jabart E, Driver I, Rock J, Goga A, Khan SA, Lawson DA, Werb Z, Kessenbrock K. Profiling human breast epithelial cells using single cell RNA sequencing identifies cell diversity. Nat Commun. 2018 May 23; 9(1):2028. PMID: 29795293.
      View in: PubMed
    2. Takai K, Drain AP, Lawson DA, Littlepage LE, Karpuj M, Kessenbrock K, Le A, Inoue K, Weaver VM, Werb Z. Discoidin domain receptor 1 (DDR1) ablation promotes tissue fibrosis and hypoxia to induce aggressive basal-like breast cancers. Genes Dev. 2018 Feb 01; 32(3-4):244-257. PMID: 29483153.
      View in: PubMed
    3. Devignes CS, Aslan Y, Brenot A, Devillers A, Schepers K, Fabre S, Chou J, Casbon AJ, Werb Z, Provot S. HIF signaling in osteoblast-lineage cells promotes systemic breast cancer growth and metastasis in mice. Proc Natl Acad Sci U S A. 2018 Jan 16. PMID: 29339479.
      View in: PubMed
    4. Sun Z, Wang CY, Lawson DA, Kwek S, Velozo HG, Owyong M, Lai MD, Fong L, Wilson M, Su H, Werb Z, Cooke DL. Single-cell RNA sequencing reveals gene expression signatures of breast cancer-associated endothelial cells. Oncotarget. 2018 Feb 16; 9(13):10945-10961. PMID: 29541388.
      View in: PubMed
    5. Gonzalez H, Robles I, Werb Z. Innate and acquired immune surveillance in the postdissemination phase of metastasis. FEBS J. 2018 Feb; 285(4):654-664. PMID: 29131550.
      View in: PubMed
    6. Cooke DL, McCoy DB, Halbach VV, Hetts SW, Amans MR, Dowd CF, Higashida RT, Lawson D, Nelson J, Wang CY, Kim H, Werb Z, McCulloch C, Hashimoto T, Su H, Sun Z. Endovascular Biopsy: In Vivo Cerebral Aneurysm Endothelial Cell Sampling and Gene Expression Analysis. Transl Stroke Res. 2018 Feb; 9(1):20-33. PMID: 28900857.
      View in: PubMed
    7. Kessenbrock K, Smith P, Steenbeek SC, Pervolarakis N, Kumar R, Minami Y, Goga A, Hinck L, Werb Z. Diverse regulation of mammary epithelial growth and branching morphogenesis through noncanonical Wnt signaling. Proc Natl Acad Sci U S A. 2017 03 21; 114(12):3121-3126. PMID: 28270600.
      View in: PubMed
    8. Shahi P, Wang CY, Lawson DA, Slorach EM, Lu A, Yu Y, Lai MD, Gonzalez Velozo H, Werb Z. ZNF503/Zpo2 drives aggressive breast cancer progression by down-regulation of GATA3 expression. Proc Natl Acad Sci U S A. 2017 03 21; 114(12):3169-3174. PMID: 28258171.
      View in: PubMed
    9. Takai K, Le A, Weaver VM, Werb Z. Targeting the cancer-associated fibroblasts as a treatment in triple-negative breast cancer. Oncotarget. 2016 Dec 13; 7(50):82889-82901. PMID: 27756881.
      View in: PubMed
    10. Wang CY, Shahi P, Huang JT, Phan NN, Sun Z, Lin YC, Lai MD, Werb Z. Systematic analysis of the achaete-scute complex-like gene signature in clinical cancer patients. Mol Clin Oncol. 2017 Jan; 6(1):7-18. PMID: 28123722.
      View in: PubMed
    11. Horiuchi D, Camarda R, Zhou AY, Yau C, Momcilovic O, Balakrishnan S, Corella AN, Eyob H, Kessenbrock K, Lawson DA, Marsh LA, Anderton BN, Rohrberg J, Kunder R, Bazarov AV, Yaswen P, McManus MT, Rugo HS, Werb Z, Goga A. PIM1 kinase inhibition as a targeted therapy against triple-negative breast tumors with elevated MYC expression. Nat Med. 2016 11; 22(11):1321-1329. PMID: 27775705.
      View in: PubMed
    12. Allaoui R, Bergenfelz C, Mohlin S, Hagerling C, Salari K, Werb Z, Anderson RL, Ethier SP, Jirström K, Påhlman S, Bexell D, Tahin B, Johansson ME, Larsson C, Leandersson K. Cancer-associated fibroblast-secreted CXCL16 attracts monocytes to promote stroma activation in triple-negative breast cancers. Nat Commun. 2016 Oct 11; 7:13050. PMID: 27725631.
      View in: PubMed
    13. Koledova Z, Zhang X, Streuli C, Clarke RB, Klein OD, Werb Z, Lu P. SPRY1 regulates mammary epithelial morphogenesis by modulating EGFR-dependent stromal paracrine signaling and ECM remodeling. Proc Natl Acad Sci U S A. 2016 09 27; 113(39):E5731-40. PMID: 27621461.
      View in: PubMed
    14. Trivedi A, Zhang H, Ekeledo A, Lee S, Werb Z, Plant GW, Noble-Haeusslein LJ. Deficiency in matrix metalloproteinase-2 results in long-term vascular instability and regression in the injured mouse spinal cord. Exp Neurol. 2016 Oct; 284(Pt A):50-62. PMID: 27468657.
      View in: PubMed
    15. Chou J, Chan MF, Werb Z. Metalloproteinases: a Functional Pathway for Myeloid Cells. Microbiol Spectr. 2016 04; 4(2). PMID: 27227311; PMCID: PMC4888795.
    16. Hagerling C, Werb Z. Neutrophils: Critical components in experimental animal models of cancer. Semin Immunol. 2016 04; 28(2):197-204. PMID: 26976824.
      View in: PubMed
    17. Williams KE, Lemieux GA, Hassis ME, Olshen AB, Fisher SJ, Werb Z. Quantitative proteomic analyses of mammary organoids reveals distinct signatures after exposure to environmental chemicals. Proc Natl Acad Sci U S A. 2016 Mar 08; 113(10):E1343-51. PMID: 26903627; PMCID: PMC4790982.
    18. Lawson DA, Werb Z, Zong Y, Goldstein AS. The Cleared Mammary Fat Pad Transplantation Assay for Mammary Epithelial Organogenesis. Cold Spring Harb Protoc. 2015 Dec 02; 2015(12):pdb.prot078071. PMID: 26631119; PMCID: PMC4965229 [Available on 12/02/16].
    19. Kim M, M Shewan A, Ewald AJ, Werb Z, Mostov KE. p114RhoGEF governs cell motility and lumen formation during tubulogenesis through a ROCK-myosin-II pathway. J Cell Sci. 2015 Dec 01; 128(23):4317-27. PMID: 26483385; PMCID: PMC4712812 [Available on 12/01/16].
    20. Lawson DA, Bhakta NR, Kessenbrock K, Prummel KD, Yu Y, Takai K, Zhou A, Eyob H, Balakrishnan S, Wang CY, Yaswen P, Goga A, Werb Z. Single-cell analysis reveals a stem-cell program in human metastatic breast cancer cells. Nature. 2015 Oct 01; 526(7571):131-5. PMID: 26416748; PMCID: PMC4648562.
    21. Plaks V, Boldajipour B, Linnemann JR, Nguyen NH, Kersten K, Wolf Y, Casbon AJ, Kong N, van den Bijgaart RJ, Sheppard D, Melton AC, Krummel MF, Werb Z. Adaptive Immune Regulation of Mammary Postnatal Organogenesis. Dev Cell. 2015 Sep 14; 34(5):493-504. PMID: 26321127; PMCID: PMC4573906.
    22. Sun Z, Lawson DA, Sinclair E, Wang CY, Lai MD, Hetts SW, Higashida RT, Dowd CF, Halbach VV, Werb Z, Su H, Cooke DL. Endovascular biopsy: Strategy for analyzing gene expression profiles of individual endothelial cells obtained from human vessels?. Biotechnol Rep (Amst). 2015 Sep; 7:157-165. PMID: 26989654.
      View in: PubMed
    23. Chan MF, Werb Z. Animal Models of Corneal Injury. Bio Protoc. 2015 Jul 05; 5(13):e1516. PMID: 26191536.
      View in: PubMed
    24. Chan MF, Werb Z. Confocal Imaging of Myeloid Cells in the Corneal Stroma of Live Mice. Bio Protoc. 2015 Jul 05; 5(13):e1517. PMID: 26191537.
      View in: PubMed
    25. Werb Z, Lu P. The Role of Stroma in Tumor Development. Cancer J. 2015 Jul-Aug; 21(4):250-3. PMID: 26222075; PMCID: PMC4963227.
    26. Depeille P, Henricks LM, van de Ven RA, Lemmens E, Wang CY, Matli M, Werb Z, Haigis KM, Donner D, Warren R, Roose JP. RasGRP1 opposes proliferative EGFR-SOS1-Ras signals and restricts intestinal epithelial cell growth. Nat Cell Biol. 2015 Jun; 17(6):804-15. PMID: 26005835; PMCID: PMC4652934.
    27. Chambers AF, Werb Z. Invasion and metastasis--recent advances and future challenges. J Mol Med (Berl). 2015 Apr; 93(4):361-8. PMID: 25772709.
      View in: PubMed
    28. Plaks V, Kong N, Werb Z. The cancer stem cell niche: how essential is the niche in regulating stemness of tumor cells? Cell Stem Cell. 2015 Mar 05; 16(3):225-38. PMID: 25748930; PMCID: PMC4355577.
    29. Casbon AJ, Lohela M, Werb Z. Delineating CSF-1-dependent regulation of myeloid cell diversity in tumors. Oncoimmunology. 2015 Jun; 4(6):e1008871. PMID: 26155427.
      View in: PubMed
    30. Kessenbrock K, Wang CY, Werb Z. Matrix metalloproteinases in stem cell regulation and cancer. Matrix Biol. 2015 May-Jul; 44-46:184-90. PMID: 25661772; PMCID: PMC4498798.
    31. Casbon AJ, Reynaud D, Park C, Khuc E, Gan DD, Schepers K, Passegué E, Werb Z. Invasive breast cancer reprograms early myeloid differentiation in the bone marrow to generate immunosuppressive neutrophils. Proc Natl Acad Sci U S A. 2015 Feb 10; 112(6):E566-75. PMID: 25624500; PMCID: PMC4330753.
    32. Lemieux GA, Cunningham KA, Lin L, Mayer F, Werb Z, Ashrafi K. Kynurenic acid is a nutritional cue that enables behavioral plasticity. Cell. 2015 Jan 15; 160(1-2):119-31. PMID: 25594177; PMCID: PMC4334586.
    33. Shahi P, Slorach EM, Wang CY, Chou J, Lu A, Ruderisch A, Werb Z. The Transcriptional Repressor ZNF503/Zeppo2 Promotes Mammary Epithelial Cell Proliferation and Enhances Cell Invasion. J Biol Chem. 2015 Feb 06; 290(6):3803-13. PMID: 25538248; PMCID: PMC4319044.
    34. Bonnans C, Chou J, Werb Z. Remodelling the extracellular matrix in development and disease. Nat Rev Mol Cell Biol. 2014 Dec; 15(12):786-801. PMID: 25415508; PMCID: PMC4316204.
    35. Hagerling C, Casbon AJ, Werb Z. Balancing the innate immune system in tumor development. Trends Cell Biol. 2015 Apr; 25(4):214-20. PMID: 25444276; PMCID: PMC4380818.
    36. Lohela M, Casbon AJ, Olow A, Bonham L, Branstetter D, Weng N, Smith J, Werb Z. Intravital imaging reveals distinct responses of depleting dynamic tumor-associated macrophage and dendritic cell subpopulations. Proc Natl Acad Sci U S A. 2014 Nov 25; 111(47):E5086-95. PMID: 25385645; PMCID: PMC4250128.
    37. Bryant DM, Roignot J, Datta A, Overeem AW, Kim M, Yu W, Peng X, Eastburn DJ, Ewald AJ, Werb Z, Mostov KE. A molecular switch for the orientation of epithelial cell polarization. Dev Cell. 2014 Oct 27; 31(2):171-87. PMID: 25307480; PMCID: PMC4248238.
    38. Bonnans C, Lohela M, Werb Z. Real-time imaging of myeloid cells dynamics in ApcMin/+ intestinal tumors by spinning disk confocal microscopy. J Vis Exp. 2014 Oct 06; (92):51916. PMID: 25350573; PMCID: PMC4318091.
    39. Hiatt RA, Porco TC, Liu F, Balke K, Balmain A, Barlow J, Braithwaite D, Diez-Roux AV, Kushi LH, Moasser MM, Werb Z, Windham GC, Rehkopf DH. A multilevel model of postmenopausal breast cancer incidence. Cancer Epidemiol Biomarkers Prev. 2014 Oct; 23(10):2078-92. PMID: 25017248.
      View in: PubMed
    40. Levine JM, Cohen ND, Heller M, Fajt VR, Levine GJ, Kerwin SC, Trivedi AA, Fandel TM, Werb Z, Modestino A, Noble-Haeusslein LJ. Efficacy of a metalloproteinase inhibitor in spinal cord injured dogs. PLoS One. 2014; 9(5):e96408. PMID: 24788791; PMCID: PMC4006832.
    41. Cheung KJ, Gabrielson E, Werb Z, Ewald AJ. Collective invasion in breast cancer requires a conserved basal epithelial program. Cell. 2013 Dec 19; 155(7):1639-51. PMID: 24332913; PMCID: PMC3941206.
    42. Lemieux GA, Keiser MJ, Sassano MF, Laggner C, Mayer F, Bainton RJ, Werb Z, Roth BL, Shoichet BK, Ashrafi K. In silico molecular comparisons of C. elegans and mammalian pharmacology identify distinct targets that regulate feeding. PLoS Biol. 2013 Nov; 11(11):e1001712. PMID: 24260022; PMCID: PMC3833878.
    43. Plaks V, Koopman CD, Werb Z. Cancer. Circulating tumor cells. Science. 2013 Sep 13; 341(6151):1186-8. PMID: 24031008; PMCID: PMC3842225.
    44. Brabletz T, Lyden D, Steeg PS, Werb Z. Roadblocks to translational advances on metastasis research. Nat Med. 2013 Sep; 19(9):1104-9. PMID: 24013756; PMCID: PMC3972758.
    45. Chou J, Shahi P, Werb Z. microRNA-mediated regulation of the tumor microenvironment. Cell Cycle. 2013 Oct 15; 12(20):3262-71. PMID: 24036551; PMCID: PMC3885637.
    46. Kessenbrock K, Dijkgraaf GJ, Lawson DA, Littlepage LE, Shahi P, Pieper U, Werb Z. A role for matrix metalloproteinases in regulating mammary stem cell function via the Wnt signaling pathway. Cell Stem Cell. 2013 Sep 05; 13(3):300-13. PMID: 23871604; PMCID: PMC3769456.
    47. Chan MF, Li J, Bertrand A, Casbon AJ, Lin JH, Maltseva I, Werb Z. Protective effects of matrix metalloproteinase-12 following corneal injury. J Cell Sci. 2013 Sep 01; 126(Pt 17):3948-60. PMID: 23813962; PMCID: PMC3757333.
    48. Plaks V, Rinkenberger J, Dai J, Flannery M, Sund M, Kanasaki K, Ni W, Kalluri R, Werb Z. Matrix metalloproteinase-9 deficiency phenocopies features of preeclampsia and intrauterine growth restriction. Proc Natl Acad Sci U S A. 2013 Jul 02; 110(27):11109-14. PMID: 23776237; PMCID: PMC3704020.
    49. Morrisey EE, Cardoso WV, Lane RH, Rabinovitch M, Abman SH, Ai X, Albertine KH, Bland RD, Chapman HA, Checkley W, Epstein JA, Kintner CR, Kumar M, Minoo P, Mariani TJ, McDonald DM, Mukouyama YS, Prince LS, Reese J, Rossant J, Shi W, Sun X, Werb Z, Whitsett JA, Gail D, Blaisdell CJ, Lin QS. Molecular determinants of lung development. Ann Am Thorac Soc. 2013 Apr; 10(2):S12-6. PMID: 23607856.
      View in: PubMed
    50. Chou J, Lin JH, Brenot A, Kim JW, Provot S, Werb Z. GATA3 suppresses metastasis and modulates the tumour microenvironment by regulating microRNA-29b expression. Nat Cell Biol. 2013 Feb; 15(2):201-13. PMID: 23354167; PMCID: PMC3660859.
    51. Plaks V, Brenot A, Lawson DA, Linnemann JR, Van Kappel EC, Wong KC, de Sauvage F, Klein OD, Werb Z. Lgr5-expressing cells are sufficient and necessary for postnatal mammary gland organogenesis. Cell Rep. 2013 Jan 31; 3(1):70-8. PMID: 23352663; PMCID: PMC3563842.
    52. Chou J, Werb Z. MicroRNAs play a big role in regulating ovarian cancer-associated fibroblasts and the tumor microenvironment. Cancer Discov. 2012 Dec; 2(12):1078-80. PMID: 23230184; PMCID: PMC3531831.
    53. Wang X, Yu YY, Lieu S, Yang F, Lang J, Lu C, Werb Z, Hu D, Miclau T, Marcucio R, Colnot C. MMP9 regulates the cellular response to inflammation after skeletal injury. Bone. 2013 Jan; 52(1):111-9. PMID: 23010105; PMCID: PMC3513654.
    54. Nguyen-Ngoc KV, Cheung KJ, Brenot A, Shamir ER, Gray RS, Hines WC, Yaswen P, Werb Z, Ewald AJ. ECM microenvironment regulates collective migration and local dissemination in normal and malignant mammary epithelium. Proc Natl Acad Sci U S A. 2012 Sep 25; 109(39):E2595-604. PMID: 22923691; PMCID: PMC3465416.
    55. Caudrillier A, Kessenbrock K, Gilliss BM, Nguyen JX, Marques MB, Monestier M, Toy P, Werb Z, Looney MR. Platelets induce neutrophil extracellular traps in transfusion-related acute lung injury. J Clin Invest. 2012 Jul; 122(7):2661-71. PMID: 22684106; PMCID: PMC3386815.
    56. Littlepage LE, Adler AS, Kouros-Mehr H, Huang G, Chou J, Krig SR, Griffith OL, Korkola JE, Qu K, Lawson DA, Xue Q, Sternlicht MD, Dijkgraaf GJ, Yaswen P, Rugo HS, Sweeney CA, Collins CC, Gray JW, Chang HY, Werb Z. The transcription factor ZNF217 is a prognostic biomarker and therapeutic target during breast cancer progression. Cancer Discov. 2012 Jul; 2(7):638-51. PMID: 22728437; PMCID: PMC3546490.
    57. Nakasone ES, Askautrud HA, Kees T, Park JH, Plaks V, Ewald AJ, Fein M, Rasch MG, Tan YX, Qiu J, Park J, Sinha P, Bissell MJ, Frengen E, Werb Z, Egeblad M. Imaging tumor-stroma interactions during chemotherapy reveals contributions of the microenvironment to resistance. Cancer Cell. 2012 Apr 17; 21(4):488-503. PMID: 22516258; PMCID: PMC3332002.
    58. Engelhardt JJ, Boldajipour B, Beemiller P, Pandurangi P, Sorensen C, Werb Z, Egeblad M, Krummel MF. Marginating dendritic cells of the tumor microenvironment cross-present tumor antigens and stably engage tumor-specific T cells. Cancer Cell. 2012 Mar 20; 21(3):402-17. PMID: 22439936; PMCID: PMC3311997.
    59. Lu P, Weaver VM, Werb Z. The extracellular matrix: a dynamic niche in cancer progression. J Cell Biol. 2012 Feb 20; 196(4):395-406. PMID: 22351925; PMCID: PMC3283993.
    60. Ewald AJ, Huebner RJ, Palsdottir H, Lee JK, Perez MJ, Jorgens DM, Tauscher AN, Cheung KJ, Werb Z, Auer M. Mammary collective cell migration involves transient loss of epithelial features and individual cell migration within the epithelium. J Cell Sci. 2012 Jun 01; 125(Pt 11):2638-54. PMID: 22344263; PMCID: PMC3403234.
    61. Phillips JJ, Huillard E, Robinson AE, Ward A, Lum DH, Polley MY, Rosen SD, Rowitch DH, Werb Z. Heparan sulfate sulfatase SULF2 regulates PDGFRa signaling and growth in human and mouse malignant glioma. J Clin Invest. 2012 Mar; 122(3):911-22. PMID: 22293178; PMCID: PMC3287216.
    62. Partanen JI, Tervonen TA, Myllynen M, Lind E, Imai M, Katajisto P, Dijkgraaf GJ, Kovanen PE, Mäkelä TP, Werb Z, Klefström J. Tumor suppressor function of Liver kinase B1 (Lkb1) is linked to regulation of epithelial integrity. Proc Natl Acad Sci U S A. 2012 Feb 14; 109(7):E388-97. PMID: 22308451; PMCID: PMC3289385.
    63. Lu P, Takai K, Weaver VM, Werb Z. Extracellular matrix degradation and remodeling in development and disease. Cold Spring Harb Perspect Biol. 2011 Dec 01; 3(12). PMID: 21917992; PMCID: PMC3225943.
    64. Zhang H, Trivedi A, Lee JU, Lohela M, Lee SM, Fandel TM, Werb Z, Noble-Haeusslein LJ. Matrix metalloproteinase-9 and stromal cell-derived factor-1 act synergistically to support migration of blood-borne monocytes into the injured spinal cord. J Neurosci. 2011 Nov 02; 31(44):15894-903. PMID: 22049432; PMCID: PMC3265932.
    65. Lin L, Bankaitis E, Heimbach L, Li N, Abrink M, Pejler G, An L, Diaz LA, Werb Z, Liu Z. Dual targets for mouse mast cell protease-4 in mediating tissue damage in experimental bullous pemphigoid. J Biol Chem. 2011 Oct 28; 286(43):37358-67. PMID: 21880713; PMCID: PMC3199483.
    66. Hong JS, Greenlee KJ, Pitchumani R, Lee SH, Song LZ, Shan M, Chang SH, Park PW, Dong C, Werb Z, Bidani A, Corry DB, Kheradmand F. Dual protective mechanisms of matrix metalloproteinases 2 and 9 in immune defense against Streptococcus pneumoniae. J Immunol. 2011 Jun 01; 186(11):6427-36. PMID: 21508260; PMCID: PMC3546495.
    67. Khokha R, Werb Z. Mammary gland reprogramming: metalloproteinases couple form with function. Cold Spring Harb Perspect Biol. 2011 Apr 01; 3(4). PMID: 21106646; PMCID: PMC3062217.
    68. Kessenbrock K, Brown M, Werb Z. Measuring matrix metalloproteinase activity in macrophages and polymorphonuclear leukocytes. Curr Protoc Immunol. 2011 Apr; Chapter 14:Unit14.24. PMID: 21462166; PMCID: PMC3538162.
    69. Lemieux GA, Liu J, Mayer N, Bainton RJ, Ashrafi K, Werb Z. A whole-organism screen identifies new regulators of fat storage. Nat Chem Biol. 2011 Apr; 7(4):206-13. PMID: 21390037; PMCID: PMC3076723.
    70. Slorach EM, Chou J, Werb Z. Zeppo1 is a novel metastasis promoter that represses E-cadherin expression and regulates p120-catenin isoform expression and localization. Genes Dev. 2011 Mar 01; 25(5):471-84. PMID: 21317240; PMCID: PMC3049288.
    71. Ewald AJ, Werb Z, Egeblad M. Dynamic, long-term in vivo imaging of tumor-stroma interactions in mouse models of breast cancer using spinning-disk confocal microscopy. Cold Spring Harb Protoc. 2011 Feb 01; 2011(2):pdb.top97. PMID: 21285277; PMCID: PMC3533368.
    72. Ewald AJ, Werb Z, Egeblad M. Monitoring of vital signs for long-term survival of mice under anesthesia. Cold Spring Harb Protoc. 2011 Feb 01; 2011(2):pdb.prot5563. PMID: 21285263; PMCID: PMC3531964.
    73. Ewald AJ, Werb Z, Egeblad M. Preparation of mice for long-term intravital imaging of the mammary gland. Cold Spring Harb Protoc. 2011 Feb 01; 2011(2):pdb.prot5562. PMID: 21285262; PMCID: PMC3531961.
    74. Lieu S, Hansen E, Dedini R, Behonick D, Werb Z, Miclau T, Marcucio R, Colnot C. Impaired remodeling phase of fracture repair in the absence of matrix metalloproteinase-2. Dis Model Mech. 2011 Mar; 4(2):203-11. PMID: 21135056; PMCID: PMC3046093.
    75. Pozniak CD, Langseth AJ, Dijkgraaf GJ, Choe Y, Werb Z, Pleasure SJ. Sox10 directs neural stem cells toward the oligodendrocyte lineage by decreasing Suppressor of Fused expression. Proc Natl Acad Sci U S A. 2010 Dec 14; 107(50):21795-800. PMID: 21098272; PMCID: PMC3003047.
    76. Werb Z. The joy of a career in cell biology. Mol Biol Cell. 2010 Nov 15; 21(22):3764-6. PMID: 21079003; PMCID: PMC2982121.
    77. Werb Z. The extracellular matrix and disease: An interview with Zena Werb. Interviewed by Kristin H. Kain. Dis Model Mech. 2010 Sep-Oct; 3(9-10):513-6. PMID: 20699476.
      View in: PubMed
    78. Egeblad M, Nakasone ES, Werb Z. Tumors as organs: complex tissues that interface with the entire organism. Dev Cell. 2010 Jun 15; 18(6):884-901. PMID: 20627072; PMCID: PMC2905377.
    79. Kessenbrock K, Plaks V, Werb Z. Matrix metalloproteinases: regulators of the tumor microenvironment. Cell. 2010 Apr 02; 141(1):52-67. PMID: 20371345; PMCID: PMC2862057.
    80. Zhang H, Adwanikar H, Werb Z, Noble-Haeusslein LJ. Matrix metalloproteinases and neurotrauma: evolving roles in injury and reparative processes. Neuroscientist. 2010 Apr; 16(2):156-70. PMID: 20400713; PMCID: PMC2858362.
    81. Sounni NE, Dehne K, van Kempen L, Egeblad M, Affara NI, Cuevas I, Wiesen J, Junankar S, Korets L, Lee J, Shen J, Morrison CJ, Overall CM, Krane SM, Werb Z, Boudreau N, Coussens LM. Stromal regulation of vessel stability by MMP14 and TGFbeta. Dis Model Mech. 2010 May-Jun; 3(5-6):317-32. PMID: 20223936; PMCID: PMC2860851.
    82. Littlepage LE, Sternlicht MD, Rougier N, Phillips J, Gallo E, Yu Y, Williams K, Brenot A, Gordon JI, Werb Z. Matrix metalloproteinases contribute distinct roles in neuroendocrine prostate carcinogenesis, metastasis, and angiogenesis progression. Cancer Res. 2010 Mar 15; 70(6):2224-34. PMID: 20215503; PMCID: PMC2840052.
    83. Ortega N, Wang K, Ferrara N, Werb Z, Vu TH. Complementary interplay between matrix metalloproteinase-9, vascular endothelial growth factor and osteoclast function drives endochondral bone formation. Dis Model Mech. 2010 Mar-Apr; 3(3-4):224-35. PMID: 20142327; PMCID: PMC2869494.
    84. Ohki M, Ohki Y, Ishihara M, Nishida C, Tashiro Y, Akiyama H, Komiyama H, Lund LR, Nitta A, Yamada K, Zhu Z, Ogawa H, Yagita H, Okumura K, Nakauchi H, Werb Z, Heissig B, Hattori K. Tissue type plasminogen activator regulates myeloid-cell dependent neoangiogenesis during tissue regeneration. Blood. 2010 May 27; 115(21):4302-12. PMID: 20110420; PMCID: PMC2879105.
    85. Chou J, Provot S, Werb Z. GATA3 in development and cancer differentiation: cells GATA have it! J Cell Physiol. 2010 Jan; 222(1):42-9. PMID: 19798694; PMCID: PMC2915440.
    86. Lohela M, Werb Z. Intravital imaging of stromal cell dynamics in tumors. Curr Opin Genet Dev. 2010 Feb; 20(1):72-8. PMID: 19942428; PMCID: PMC2821950.
    87. Lederle W, Hartenstein B, Meides A, Kunzelmann H, Werb Z, Angel P, Mueller MM. MMP13 as a stromal mediator in controlling persistent angiogenesis in skin carcinoma. Carcinogenesis. 2010 Jul; 31(7):1175-84. PMID: 19892798; PMCID: PMC2893794.
    88. Atabai K, Jame S, Azhar N, Kuo A, Lam M, McKleroy W, Dehart G, Rahman S, Xia DD, Melton AC, Wolters P, Emson CL, Turner SM, Werb Z, Sheppard D. Mfge8 diminishes the severity of tissue fibrosis in mice by binding and targeting collagen for uptake by macrophages. J Clin Invest. 2009 Dec; 119(12):3713-22. PMID: 19884654; PMCID: PMC2786804.
    89. Lilla JN, Werb Z. Mast cells contribute to the stromal microenvironment in mammary gland branching morphogenesis. Dev Biol. 2010 Jan 01; 337(1):124-33. PMID: 19850030; PMCID: PMC2787992.
    90. Kessenbrock K, Krumbholz M, Schönermarck U, Back W, Gross WL, Werb Z, Gröne HJ, Brinkmann V, Jenne DE. Netting neutrophils in autoimmune small-vessel vasculitis. Nat Med. 2009 Jun; 15(6):623-5. PMID: 19448636; PMCID: PMC2760083.
    91. Bengatta S, Arnould C, Letavernier E, Monge M, de Préneuf HM, Werb Z, Ronco P, Lelongt B. MMP9 and SCF protect from apoptosis in acute kidney injury. J Am Soc Nephrol. 2009 Apr; 20(4):787-97. PMID: 19329763; PMCID: PMC2663840.
    92. Lilla JN, Joshi RV, Craik CS, Werb Z. Active plasma kallikrein localizes to mast cells and regulates epithelial cell apoptosis, adipocyte differentiation, and stromal remodeling during mammary gland involution. J Biol Chem. 2009 May 15; 284(20):13792-803. PMID: 19297327; PMCID: PMC2679480.
    93. Hsu JY, Bourguignon LY, Adams CM, Peyrollier K, Zhang H, Fandel T, Cun CL, Werb Z, Noble-Haeusslein LJ. Matrix metalloproteinase-9 facilitates glial scar formation in the injured spinal cord. J Neurosci. 2008 Dec 10; 28(50):13467-77. PMID: 19074020; PMCID: PMC2712293.
    94. Fernandez-Gonzalez R, Illa-Bochaca I, Welm BE, Fleisch MC, Werb Z, Ortiz-de-Solorzano C, Barcellos-Hoff MH. Mapping mammary gland architecture using multi-scale in situ analysis. Integr Biol (Camb). 2009 Jan; 1(1):80-9. PMID: 20023794; PMCID: PMC2847439.
    95. Lu P, Werb Z. Patterning mechanisms of branched organs. Science. 2008 Dec 05; 322(5907):1506-9. PMID: 19056977; PMCID: PMC2645229.
    96. Egeblad M, Ewald AJ, Askautrud HA, Truitt ML, Welm BE, Bainbridge E, Peeters G, Krummel MF, Werb Z. Visualizing stromal cell dynamics in different tumor microenvironments by spinning disk confocal microscopy. Dis Model Mech. 2008 Sep-Oct; 1(2-3):155-67; discussion 165. PMID: 19048079; PMCID: PMC2562195.
    97. Nielsen BS, Egeblad M, Rank F, Askautrud HA, Pennington CJ, Pedersen TX, Christensen IJ, Edwards DR, Werb Z, Lund LR. Matrix metalloproteinase 13 is induced in fibroblasts in polyomavirus middle T antigen-driven mammary carcinoma without influencing tumor progression. PLoS One. 2008 Aug 13; 3(8):e2959. PMID: 18698413; PMCID: PMC2493034.
    98. Lu P, Ewald AJ, Martin GR, Werb Z. Genetic mosaic analysis reveals FGF receptor 2 function in terminal end buds during mammary gland branching morphogenesis. Dev Biol. 2008 Sep 01; 321(1):77-87. PMID: 18585375; PMCID: PMC2582391.
    99. Riedl J, Crevenna AH, Kessenbrock K, Yu JH, Neukirchen D, Bista M, Bradke F, Jenne D, Holak TA, Werb Z, Sixt M, Wedlich-Soldner R. Lifeact: a versatile marker to visualize F-actin. Nat Methods. 2008 Jul; 5(7):605-7. PMID: 18536722; PMCID: PMC2814344.
    100. Martín-Belmonte F, Yu W, Rodríguez-Fraticelli AE, Ewald AJ, Ewald A, Werb Z, Alonso MA, Mostov K. Cell-polarity dynamics controls the mechanism of lumen formation in epithelial morphogenesis. Curr Biol. 2008 Apr 08; 18(7):507-13. PMID: 18394894; PMCID: PMC2405957.
    101. Ewald AJ, Brenot A, Duong M, Chan BS, Werb Z. Collective epithelial migration and cell rearrangements drive mammary branching morphogenesis. Dev Cell. 2008 Apr; 14(4):570-81. PMID: 18410732; PMCID: PMC2773823.
    102. Lu P, Yu Y, Perdue Y, Werb Z. The apical ectodermal ridge is a timer for generating distal limb progenitors. Development. 2008 Apr; 135(8):1395-405. PMID: 18359901; PMCID: PMC2574509.
    103. Kouros-Mehr H, Kim JW, Bechis SK, Werb Z. GATA-3 and the regulation of the mammary luminal cell fate. Curr Opin Cell Biol. 2008 Apr; 20(2):164-70. PMID: 18358709; PMCID: PMC2397451.
    104. Du R, Lu KV, Petritsch C, Liu P, Ganss R, Passegué E, Song H, Vandenberg S, Johnson RS, Werb Z, Bergers G. HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion. Cancer Cell. 2008 Mar; 13(3):206-20. PMID: 18328425; PMCID: PMC2643426.
    105. Kouros-Mehr H, Bechis SK, Slorach EM, Littlepage LE, Egeblad M, Ewald AJ, Pai SY, Ho IC, Werb Z. GATA-3 links tumor differentiation and dissemination in a luminal breast cancer model. Cancer Cell. 2008 Feb; 13(2):141-52. PMID: 18242514; PMCID: PMC2262951.
    106. Adler AS, Littlepage LE, Lin M, Kawahara TL, Wong DJ, Werb Z, Chang HY. CSN5 isopeptidase activity links COP9 signalosome activation to breast cancer progression. Cancer Res. 2008 Jan 15; 68(2):506-15. PMID: 18199546; PMCID: PMC2646416.
    107. Welm BE, Dijkgraaf GJ, Bledau AS, Welm AL, Werb Z. Lentiviral transduction of mammary stem cells for analysis of gene function during development and cancer. Cell Stem Cell. 2008 Jan 10; 2(1):90-102. PMID: 18371425; PMCID: PMC2276651.
    108. Sneddon JB, Werb Z. Location, location, location: the cancer stem cell niche. Cell Stem Cell. 2007 Dec 13; 1(6):607-11. PMID: 18371402; PMCID: PMC2571117.
    109. Heissig B, Lund LR, Akiyama H, Ohki M, Morita Y, Rømer J, Nakauchi H, Okumura K, Ogawa H, Werb Z, Danø K, Hattori K. The plasminogen fibrinolytic pathway is required for hematopoietic regeneration. Cell Stem Cell. 2007 Dec 13; 1(6):658-70. PMID: 18371407; PMCID: PMC2646407.
    110. Melani C, Sangaletti S, Barazzetta FM, Werb Z, Colombo MP. Amino-biphosphonate-mediated MMP-9 inhibition breaks the tumor-bone marrow axis responsible for myeloid-derived suppressor cell expansion and macrophage infiltration in tumor stroma. Cancer Res. 2007 Dec 01; 67(23):11438-46. PMID: 18056472; PMCID: PMC2646404.
    111. Behonick DJ, Xing Z, Lieu S, Buckley JM, Lotz JC, Marcucio RS, Werb Z, Miclau T, Colnot C. Role of matrix metalloproteinase 13 in both endochondral and intramembranous ossification during skeletal regeneration. PLoS One. 2007 Nov 07; 2(11):e1150. PMID: 17987127; PMCID: PMC2063465.
    112. Weaver V, Werb Z. G'rab'bing the microenvironment for invasion. Dev Cell. 2007 Oct; 13(4):462-3. PMID: 17925222.
      View in: PubMed
    113. Egeblad M, Shen HC, Behonick DJ, Wilmes L, Eichten A, Korets LV, Kheradmand F, Werb Z, Coussens LM. Type I collagen is a genetic modifier of matrix metalloproteinase 2 in murine skeletal development. Dev Dyn. 2007 Jun; 236(6):1683-93. PMID: 17440987; PMCID: PMC2581616.
    114. Gutiérrez-Fernández A, Inada M, Balbín M, Fueyo A, Pitiot AS, Astudillo A, Hirose K, Hirata M, Shapiro SD, Noël A, Werb Z, Krane SM, López-Otín C, Puente XS. Increased inflammation delays wound healing in mice deficient in collagenase-2 (MMP-8). FASEB J. 2007 Aug; 21(10):2580-91. PMID: 17392479; PMCID: PMC2575772.
    115. Lemieux GA, Blumenkron F, Yeung N, Zhou P, Williams J, Grammer AC, Petrovich R, Lipsky PE, Moss ML, Werb Z. The low affinity IgE receptor (CD23) is cleaved by the metalloproteinase ADAM10. J Biol Chem. 2007 May 18; 282(20):14836-44. PMID: 17389606; PMCID: PMC2582392.
    116. Fata JE, Mori H, Ewald AJ, Zhang H, Yao E, Werb Z, Bissell MJ. The MAPK(ERK-1,2) pathway integrates distinct and antagonistic signals from TGFalpha and FGF7 in morphogenesis of mouse mammary epithelium. Dev Biol. 2007 Jun 01; 306(1):193-207. PMID: 17448457; PMCID: PMC2763137.
    117. Page-McCaw A, Ewald AJ, Werb Z. Matrix metalloproteinases and the regulation of tissue remodelling. Nat Rev Mol Cell Biol. 2007 Mar; 8(3):221-33. PMID: 17318226; PMCID: PMC2760082.
    118. Atabai K, Sheppard D, Werb Z. Roles of the innate immune system in mammary gland remodeling during involution. J Mammary Gland Biol Neoplasia. 2007 Mar; 12(1):37-45. PMID: 17286210; PMCID: PMC2574498.
    119. Yu W, Fang X, Ewald A, Wong K, Hunt CA, Werb Z, Matthay MA, Mostov K. Formation of cysts by alveolar type II cells in three-dimensional culture reveals a novel mechanism for epithelial morphogenesis. Mol Biol Cell. 2007 May; 18(5):1693-700. PMID: 17332496; PMCID: PMC1855040.
    120. Levin M, Ewald AJ, McMahon M, Werb Z, Mostov K. A model of intussusceptive angiogenesis. Novartis Found Symp. 2007; 283:37-42; discussion 42-5, 238-41. PMID: 18300412.
      View in: PubMed
    121. Greenlee KJ, Werb Z, Kheradmand F. Matrix metalloproteinases in lung: multiple, multifarious, and multifaceted. Physiol Rev. 2007 Jan; 87(1):69-98. PMID: 17237343; PMCID: PMC2656382.
    122. Yeh MW, Rougier JP, Park JW, Duh QY, Wong M, Werb Z, Clark OH. Differentiated thyroid cancer cell invasion is regulated through epidermal growth factor receptor-dependent activation of matrix metalloproteinase (MMP)-2/gelatinase A. Endocr Relat Cancer. 2006 Dec; 13(4):1173-83. PMID: 17158762; PMCID: PMC2574514.
    123. Kouros-Mehr H, Werb Z. Candidate regulators of mammary branching morphogenesis identified by genome-wide transcript analysis. Dev Dyn. 2006 Dec; 235(12):3404-12. PMID: 17039550; PMCID: PMC2730892.
    124. Kouros-Mehr H, Slorach EM, Sternlicht MD, Werb Z. GATA-3 maintains the differentiation of the luminal cell fate in the mammary gland. Cell. 2006 Dec 01; 127(5):1041-55. PMID: 17129787; PMCID: PMC2646406.
    125. Lum DH, Tan J, Rosen SD, Werb Z. Gene trap disruption of the mouse heparan sulfate 6-O-endosulfatase gene, Sulf2. Mol Cell Biol. 2007 Jan; 27(2):678-88. PMID: 17116694; PMCID: PMC1800820.
    126. Greenlee KJ, Corry DB, Engler DA, Matsunami RK, Tessier P, Cook RG, Werb Z, Kheradmand F. Proteomic identification of in vivo substrates for matrix metalloproteinases 2 and 9 reveals a mechanism for resolution of inflammation. J Immunol. 2006 Nov 15; 177(10):7312-21. PMID: 17082650; PMCID: PMC2580826.
    127. Sternlicht MD, Dunning AM, Moore DH, Pharoah PD, Ginzinger DG, Chin K, Gray JW, Waldman FM, Ponder BA, Werb Z. Prognostic value of PAI1 in invasive breast cancer: evidence that tumor-specific factors are more important than genetic variation in regulating PAI1 expression. Cancer Epidemiol Biomarkers Prev. 2006 Nov; 15(11):2107-14. PMID: 17119035; PMCID: PMC2731792.
    128. Lu P, Sternlicht MD, Werb Z. Comparative mechanisms of branching morphogenesis in diverse systems. J Mammary Gland Biol Neoplasia. 2006 Oct; 11(3-4):213-28. PMID: 17120154; PMCID: PMC2577019.
    129. Hsu JY, McKeon R, Goussev S, Werb Z, Lee JU, Trivedi A, Noble-Haeusslein LJ. Matrix metalloproteinase-2 facilitates wound healing events that promote functional recovery after spinal cord injury. J Neurosci. 2006 Sep 27; 26(39):9841-50. PMID: 17005848; PMCID: PMC2659718.
    130. Sternlicht MD, Kouros-Mehr H, Lu P, Werb Z. Hormonal and local control of mammary branching morphogenesis. Differentiation. 2006 Sep; 74(7):365-81. PMID: 16916375; PMCID: PMC2580831.
    131. Lund LR, Green KA, Stoop AA, Ploug M, Almholt K, Lilla J, Nielsen BS, Christensen IJ, Craik CS, Werb Z, Danø K, Rømer J. Plasminogen activation independent of uPA and tPA maintains wound healing in gene-deficient mice. EMBO J. 2006 Jun 21; 25(12):2686-97. PMID: 16763560; PMCID: PMC1500865.
    132. Jin DK, Shido K, Kopp HG, Petit I, Shmelkov SV, Young LM, Hooper AT, Amano H, Avecilla ST, Heissig B, Hattori K, Zhang F, Hicklin DJ, Wu Y, Zhu Z, Dunn A, Salari H, Werb Z, Hackett NR, Crystal RG, Lyden D, Rafii S. Cytokine-mediated deployment of SDF-1 induces revascularization through recruitment of CXCR4+ hemangiocytes. Nat Med. 2006 May; 12(5):557-67. PMID: 16648859; PMCID: PMC2754288.
    133. Zeisberg M, Khurana M, Rao VH, Cosgrove D, Rougier JP, Werner MC, Shield CF, Werb Z, Kalluri R. Stage-specific action of matrix metalloproteinases influences progressive hereditary kidney disease. PLoS Med. 2006 Apr; 3(4):e100. PMID: 16509766; PMCID: PMC1391977.
    134. Hartenstein B, Dittrich BT, Stickens D, Heyer B, Vu TH, Teurich S, Schorpp-Kistner M, Werb Z, Angel P. Epidermal development and wound healing in matrix metalloproteinase 13-deficient mice. J Invest Dermatol. 2006 Feb; 126(2):486-96. PMID: 16374453; PMCID: PMC2767339.
    135. Uchimura K, Morimoto-Tomita M, Bistrup A, Li J, Lyon M, Gallagher J, Werb Z, Rosen SD. HSulf-2, an extracellular endoglucosamine-6-sulfatase, selectively mobilizes heparin-bound growth factors and chemokines: effects on VEGF, FGF-1, and SDF-1. BMC Biochem. 2006 Jan 17; 7:2. PMID: 16417632; PMCID: PMC1386684.
    136. Morimoto-Tomita M, Uchimura K, Bistrup A, Lum DH, Egeblad M, Boudreau N, Werb Z, Rosen SD. Sulf-2, a proangiogenic heparan sulfate endosulfatase, is upregulated in breast cancer. Neoplasia. 2005 Nov; 7(11):1001-10. PMID: 16331886; PMCID: PMC1502017.
    137. Stickens D, Zak BM, Rougier N, Esko JD, Werb Z. Mice deficient in Ext2 lack heparan sulfate and develop exostoses. Development. 2005 Nov; 132(22):5055-68. PMID: 16236767; PMCID: PMC2767329.
    138. Atabai K, Fernandez R, Huang X, Ueki I, Kline A, Li Y, Sadatmansoori S, Smith-Steinhart C, Zhu W, Pytela R, Werb Z, Sheppard D. Mfge8 is critical for mammary gland remodeling during involution. Mol Biol Cell. 2005 Dec; 16(12):5528-37. PMID: 16195353; PMCID: PMC1289399.
    139. Wall SJ, Werner E, Werb Z, DeClerck YA. Discoidin domain receptor 2 mediates tumor cell cycle arrest induced by fibrillar collagen. J Biol Chem. 2005 Dec 02; 280(48):40187-94. PMID: 16186104; PMCID: PMC2768768.
    140. Heissig B, Rafii S, Akiyama H, Ohki Y, Sato Y, Rafael T, Zhu Z, Hicklin DJ, Okumura K, Ogawa H, Werb Z, Hattori K. Low-dose irradiation promotes tissue revascularization through VEGF release from mast cells and MMP-9-mediated progenitor cell mobilization. J Exp Med. 2005 Sep 19; 202(6):739-50. PMID: 16157686; PMCID: PMC2212942.
    141. Song S, Ewald AJ, Stallcup W, Werb Z, Bergers G. PDGFRbeta+ perivascular progenitor cells in tumours regulate pericyte differentiation and vascular survival. Nat Cell Biol. 2005 Sep; 7(9):870-9. PMID: 16113679; PMCID: PMC2771163.
    142. Sternlicht MD, Sunnarborg SW, Kouros-Mehr H, Yu Y, Lee DC, Werb Z. Mammary ductal morphogenesis requires paracrine activation of stromal EGFR via ADAM17-dependent shedding of epithelial amphiregulin. Development. 2005 Sep; 132(17):3923-33. PMID: 16079154; PMCID: PMC2771180.
    143. Radisky DC, Levy DD, Littlepage LE, Liu H, Nelson CM, Fata JE, Leake D, Godden EL, Albertson DG, Nieto MA, Werb Z, Bissell MJ. Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability. Nature. 2005 Jul 07; 436(7047):123-7. PMID: 16001073; PMCID: PMC2784913.
    144. Carlson TR, Yan Y, Wu X, Lam MT, Tang GL, Beverly LJ, Messina LM, Capobianco AJ, Werb Z, Wang R. Endothelial expression of constitutively active Notch4 elicits reversible arteriovenous malformations in adult mice. Proc Natl Acad Sci U S A. 2005 Jul 12; 102(28):9884-9. PMID: 15994223; PMCID: PMC1175015.
    145. Heissig B, Ohki Y, Sato Y, Rafii S, Werb Z, Hattori K. A role for niches in hematopoietic cell development. Hematology. 2005 Jun; 10(3):247-53. PMID: 16019473.
      View in: PubMed
    146. Littlepage LE, Egeblad M, Werb Z. Coevolution of cancer and stromal cellular responses. Cancer Cell. 2005 Jun; 7(6):499-500. PMID: 15950897.
      View in: PubMed
    147. Liu Z, Li N, Diaz LA, Shipley M, Senior RM, Werb Z. Synergy between a plasminogen cascade and MMP-9 in autoimmune disease. J Clin Invest. 2005 Apr; 115(4):879-87. PMID: 15841177; PMCID: PMC1070424.
    148. Ortega N, Behonick DJ, Colnot C, Cooper DN, Werb Z. Galectin-3 is a downstream regulator of matrix metalloproteinase-9 function during endochondral bone formation. Mol Biol Cell. 2005 Jun; 16(6):3028-39. PMID: 15800063; PMCID: PMC1142445.
    149. Perez SE, Cano DA, Dao-Pick T, Rougier JP, Werb Z, Hebrok M. Matrix metalloproteinases 2 and 9 are dispensable for pancreatic islet formation and function in vivo. Diabetes. 2005 Mar; 54(3):694-701. PMID: 15734845; PMCID: PMC2771170.
    150. Lee MM, Yoon BJ, Osiewicz K, Preston M, Bundy B, van Heeckeren AM, Werb Z, Soloway PD. Tissue inhibitor of metalloproteinase 1 regulates resistance to infection. Infect Immun. 2005 Jan; 73(1):661-5. PMID: 15618213; PMCID: PMC538985.
    151. Stickens D, Behonick DJ, Ortega N, Heyer B, Hartenstein B, Yu Y, Fosang AJ, Schorpp-Kistner M, Angel P, Werb Z. Altered endochondral bone development in matrix metalloproteinase 13-deficient mice. Development. 2004 Dec; 131(23):5883-95. PMID: 15539485; PMCID: PMC2771178.
    152. Masson V, de la Ballina LR, Munaut C, Wielockx B, Jost M, Maillard C, Blacher S, Bajou K, Itoh T, Itohara S, Werb Z, Libert C, Foidart JM, Noël A. Contribution of host MMP-2 and MMP-9 to promote tumor vascularization and invasion of malignant keratinocytes. FASEB J. 2005 Feb; 19(2):234-6. PMID: 15550552; PMCID: PMC2771171.
    153. Mott JD, Werb Z. Regulation of matrix biology by matrix metalloproteinases. Curr Opin Cell Biol. 2004 Oct; 16(5):558-64. PMID: 15363807; PMCID: PMC2775446.
    154. Wang K, Yamamoto H, Chin JR, Werb Z, Vu TH. Epidermal growth factor receptor-deficient mice have delayed primary endochondral ossification because of defective osteoclast recruitment. J Biol Chem. 2004 Dec 17; 279(51):53848-56. PMID: 15456762; PMCID: PMC2779713.
    155. Cases S, Zhou P, Shillingford JM, Wiseman BS, Fish JD, Angle CS, Hennighausen L, Werb Z, Farese RV. Development of the mammary gland requires DGAT1 expression in stromal and epithelial tissues. Development. 2004 Jul; 131(13):3047-55. PMID: 15163627; PMCID: PMC2775443.
    156. Corry DB, Kiss A, Song LZ, Song L, Xu J, Lee SH, Werb Z, Kheradmand F. Overlapping and independent contributions of MMP2 and MMP9 to lung allergic inflammatory cell egression through decreased CC chemokines. FASEB J. 2004 Jun; 18(9):995-7. PMID: 15059974; PMCID: PMC2771179.
    157. Chantrain CF, Shimada H, Jodele S, Groshen S, Ye W, Shalinsky DR, Werb Z, Coussens LM, DeClerck YA. Stromal matrix metalloproteinase-9 regulates the vascular architecture in neuroblastoma by promoting pericyte recruitment. Cancer Res. 2004 Mar 01; 64(5):1675-86. PMID: 14996727.
      View in: PubMed
    158. Werb Z. Zena Werb [interview by Fiona M Watt]. J Cell Sci. 2004 Feb 29; 117(Pt 6):803-4. PMID: 14963020.
      View in: PubMed
    159. Ortega N, Behonick DJ, Werb Z. Matrix remodeling during endochondral ossification. Trends Cell Biol. 2004 Feb; 14(2):86-93. PMID: 15102440; PMCID: PMC2779708.
    160. Li Y, Welm B, Podsypanina K, Huang S, Chamorro M, Zhang X, Rowlands T, Egeblad M, Cowin P, Werb Z, Tan LK, Rosen JM, Varmus HE. Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells. Proc Natl Acad Sci U S A. 2003 Dec 23; 100(26):15853-8. PMID: 14668450; PMCID: PMC307657.
    161. Man AK, Young LJ, Tynan JA, Lesperance J, Egeblad M, Werb Z, Hauser CA, Muller WJ, Cardiff RD, Oshima RG. Ets2-dependent stromal regulation of mouse mammary tumors. Mol Cell Biol. 2003 Dec; 23(23):8614-25. PMID: 14612405; PMCID: PMC262691.
    162. Behonick DJ, Werb Z. A bit of give and take: the relationship between the extracellular matrix and the developing chondrocyte. Mech Dev. 2003 Nov; 120(11):1327-36. PMID: 14623441; PMCID: PMC2775453.
    163. Lambert V, Wielockx B, Munaut C, Galopin C, Jost M, Itoh T, Werb Z, Baker A, Libert C, Krell HW, Foidart JM, Noël A, Rakic JM. MMP-2 and MMP-9 synergize in promoting choroidal neovascularization. FASEB J. 2003 Dec; 17(15):2290-2. PMID: 14563686.
      View in: PubMed
    164. Whetstone WD, Hsu JY, Eisenberg M, Werb Z, Noble-Haeusslein LJ. Blood-spinal cord barrier after spinal cord injury: relation to revascularization and wound healing. J Neurosci Res. 2003 Oct 15; 74(2):227-39. PMID: 14515352; PMCID: PMC2837839.
    165. Heissig B, Werb Z, Rafii S, Hattori K. Role of c-kit/Kit ligand signaling in regulating vasculogenesis. Thromb Haemost. 2003 Oct; 90(4):570-6. PMID: 14515175.
      View in: PubMed
    166. Wiseman BS, Sternlicht MD, Lund LR, Alexander CM, Mott J, Bissell MJ, Soloway P, Itohara S, Werb Z. Site-specific inductive and inhibitory activities of MMP-2 and MMP-3 orchestrate mammary gland branching morphogenesis. J Cell Biol. 2003 Sep 15; 162(6):1123-33. PMID: 12975354; PMCID: PMC2172848.
    167. Parisi T, Beck AR, Rougier N, McNeil T, Lucian L, Werb Z, Amati B. Cyclins E1 and E2 are required for endoreplication in placental trophoblast giant cells. EMBO J. 2003 Sep 15; 22(18):4794-803. PMID: 12970191; PMCID: PMC212738.
    168. Goussev S, Hsu JY, Lin Y, Tjoa T, Maida N, Werb Z, Noble-Haeusslein LJ. Differential temporal expression of matrix metalloproteinases after spinal cord injury: relationship to revascularization and wound healing. J Neurosurg. 2003 Sep; 99(2 Suppl):188-97. PMID: 12956462; PMCID: PMC2792200.
    169. Solberg H, Rinkenberger J, Danø K, Werb Z, Lund LR. A functional overlap of plasminogen and MMPs regulates vascularization during placental development. Development. 2003 Sep; 130(18):4439-50. PMID: 12900459; PMCID: PMC2775444.
    170. Colnot C, Thompson Z, Miclau T, Werb Z, Helms JA. Altered fracture repair in the absence of MMP9. Development. 2003 Sep; 130(17):4123-33. PMID: 12874132; PMCID: PMC2778064.
    171. Luk HW, Noble LJ, Werb Z. Macrophages contribute to the maintenance of stable regenerating neurites following peripheral nerve injury. J Neurosci Res. 2003 Sep 01; 73(5):644-58. PMID: 12929132; PMCID: PMC2792202.
    172. Fata JE, Werb Z, Bissell MJ. Regulation of mammary gland branching morphogenesis by the extracellular matrix and its remodeling enzymes. Breast Cancer Res. 2004; 6(1):1-11. PMID: 14680479; PMCID: PMC314442.
    173. Slorach EM, Werb Z. Epithelial morphogenesis: Netrin comes to a sticky and terminal end. Curr Biol. 2003 Jun 17; 13(12):R491-3. PMID: 12814570.
      View in: PubMed
    174. Hamano Y, Zeisberg M, Sugimoto H, Lively JC, Maeshima Y, Yang C, Hynes RO, Werb Z, Sudhakar A, Kalluri R. Physiological levels of tumstatin, a fragment of collagen IV alpha3 chain, are generated by MMP-9 proteolysis and suppress angiogenesis via alphaV beta3 integrin. Cancer Cell. 2003 Jun; 3(6):589-601. PMID: 12842087; PMCID: PMC2775452.
    175. Gustafsson E, Aszodi A, Ortega N, Hunziker EB, Denker HW, Werb Z, Fassler R. Role of collagen type II and perlecan in skeletal development. Ann N Y Acad Sci. 2003 May; 995:140-50. PMID: 12814946.
      View in: PubMed
    176. Ortega N, Behonick D, Stickens D, Werb Z. How proteases regulate bone morphogenesis. Ann N Y Acad Sci. 2003 May; 995:109-16. PMID: 12814943.
      View in: PubMed
    177. Heissig B, Hattori K, Friedrich M, Rafii S, Werb Z. Angiogenesis: vascular remodeling of the extracellular matrix involves metalloproteinases. Curr Opin Hematol. 2003 Mar; 10(2):136-41. PMID: 12579040.
      View in: PubMed
    178. Vu TH, Alemayehu Y, Werb Z. New insights into saccular development and vascular formation in lung allografts under the renal capsule. Mech Dev. 2003 Mar; 120(3):305-13. PMID: 12591600; PMCID: PMC2774927.
    179. Affolter M, Bellusci S, Itoh N, Shilo B, Thiery JP, Werb Z. Tube or not tube: remodeling epithelial tissues by branching morphogenesis. Dev Cell. 2003 Jan; 4(1):11-8. PMID: 12530959.
      View in: PubMed
    180. Coussens LM, Werb Z. Inflammation and cancer. Nature. 2002 Dec 19-26; 420(6917):860-7. PMID: 12490959; PMCID: PMC2803035.
    181. Ortega N, Werb Z. New functional roles for non-collagenous domains of basement membrane collagens. J Cell Sci. 2002 Nov 15; 115(Pt 22):4201-14. PMID: 12376553; PMCID: PMC2789001.
    182. Morimoto-Tomita M, Uchimura K, Werb Z, Hemmerich S, Rosen SD. Cloning and characterization of two extracellular heparin-degrading endosulfatases in mice and humans. J Biol Chem. 2002 Dec 20; 277(51):49175-85. PMID: 12368295; PMCID: PMC2779716.
    183. Hangai M, Kitaya N, Xu J, Chan CK, Kim JJ, Werb Z, Ryan SJ, Brooks PC. Matrix metalloproteinase-9-dependent exposure of a cryptic migratory control site in collagen is required before retinal angiogenesis. Am J Pathol. 2002 Oct; 161(4):1429-37. PMID: 12368215; PMCID: PMC1867273.
    184. Lambert V, Munaut C, Jost M, Noël A, Werb Z, Foidart JM, Rakic JM. Matrix metalloproteinase-9 contributes to choroidal neovascularization. Am J Pathol. 2002 Oct; 161(4):1247-53. PMID: 12368198; PMCID: PMC1867305.
    185. Weaver VM, Lelièvre S, Lakins JN, Chrenek MA, Jones JC, Giancotti F, Werb Z, Bissell MJ. beta4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium. Cancer Cell. 2002 Sep; 2(3):205-16. PMID: 12242153; PMCID: PMC2788997.
    186. Noble LJ, Donovan F, Igarashi T, Goussev S, Werb Z. Matrix metalloproteinases limit functional recovery after spinal cord injury by modulation of early vascular events. J Neurosci. 2002 Sep 01; 22(17):7526-35. PMID: 12196576; PMCID: PMC2792199.
    187. Yan Y, Shirakabe K, Werb Z. The metalloprotease Kuzbanian (ADAM10) mediates the transactivation of EGF receptor by G protein-coupled receptors. J Cell Biol. 2002 Jul 22; 158(2):221-6. PMID: 12119356; PMCID: PMC2173139.
    188. Werner E, Werb Z. Integrins engage mitochondrial function for signal transduction by a mechanism dependent on Rho GTPases. J Cell Biol. 2002 Jul 22; 158(2):357-68. PMID: 12119354; PMCID: PMC2173123.
    189. Hattori K, Heissig B, Wu Y, Dias S, Tejada R, Ferris B, Hicklin DJ, Zhu Z, Bohlen P, Witte L, Hendrikx J, Hackett NR, Crystal RG, Moore MA, Werb Z, Lyden D, Rafii S. Placental growth factor reconstitutes hematopoiesis by recruiting VEGFR1(+) stem cells from bone-marrow microenvironment. Nat Med. 2002 Aug; 8(8):841-9. PMID: 12091880; PMCID: PMC2779715.
    190. Heissig B, Hattori K, Dias S, Friedrich M, Ferris B, Hackett NR, Crystal RG, Besmer P, Lyden D, Moore MA, Werb Z, Rafii S. Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of kit-ligand. Cell. 2002 May 31; 109(5):625-37. PMID: 12062105; PMCID: PMC2826110.
    191. Wiseman BS, Werb Z. Stromal effects on mammary gland development and breast cancer. Science. 2002 May 10; 296(5570):1046-9. PMID: 12004111; PMCID: PMC2788989.
    192. Lilla J, Stickens D, Werb Z. Metalloproteases and adipogenesis: a weighty subject. Am J Pathol. 2002 May; 160(5):1551-4. PMID: 12000705; PMCID: PMC1850859.
    193. Welm B, Mott J, Werb Z. Developmental biology: vasculogenesis is a wreck without RECK. Curr Biol. 2002 Mar 19; 12(6):R209-11. PMID: 11909548.
      View in: PubMed
    194. Corry DB, Rishi K, Kanellis J, Kiss A, Song Lz LZ, Xu J, Feng L, Werb Z, Kheradmand F. Decreased allergic lung inflammatory cell egression and increased susceptibility to asphyxiation in MMP2-deficiency. Nat Immunol. 2002 Apr; 3(4):347-53. PMID: 11887181; PMCID: PMC2814346.
    195. Egeblad M, Werb Z. New functions for the matrix metalloproteinases in cancer progression. Nat Rev Cancer. 2002 Mar; 2(3):161-74. PMID: 11990853.
      View in: PubMed
    196. Kheradmand F, Rishi K, Werb Z. Signaling through the EGF receptor controls lung morphogenesis in part by regulating MT1-MMP-mediated activation of gelatinase A/MMP2. J Cell Sci. 2002 Feb 15; 115(Pt 4):839-48. PMID: 11865039; PMCID: PMC2788991.
    197. Kheradmand F, Werb Z. Shedding light on sheddases: role in growth and development. Bioessays. 2002 Jan; 24(1):8-12. PMID: 11782944.
      View in: PubMed