Zena Werb, PhD

InstitutionUniversity of California San Francisco
Address513 Parnassus Ave
San Francisco CA 94143
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    Collapse Biography 
    Collapse Education and Training
    University of Toronto (University College), , Toronto, CanadaHonors B.Sc.06/1966Biochemistry
    Rockefeller University, New York, NYPh.D.1971Cell Biology
    Strangeways Research Laboratory, Cambridge, UKPost-doc.08/1973Protein Chemistry

    Collapse Research 
    Collapse Research Activities and Funding
    Integrative approach to heterogeneity in breast cancer metastasis
    NIH/NCI U01CA199315Jun 1, 2016 - May 31, 2021
    Role: Principal Investigator
    Role of GATA3 in transcriptional pathways suppressing breast cancer metastasis
    NIH/NCI R01CA190851Jul 1, 2015 - Jun 30, 2020
    Role: Principal Investigator
    (PQC4) Fate of cells disseminating from human breast cancer xenografts
    NIH/NCI R01CA180039Aug 1, 2013 - Jun 30, 2017
    Role: Principal Investigator
    Environmental Effect on the Mammary Gland across the Lifespan
    NIH/NIEHS U01ES019458Sep 1, 2010 - Apr 30, 2015
    Role: Principal Investigator
    Caliper Life Sciences Xenogen IVIS Imager
    NIH/NCRR S10RR026435Feb 18, 2010 - Feb 17, 2011
    Role: Principal Investigator
    NIH/NCI R01CA129523Jul 1, 2008 - Apr 30, 2014
    Role: Principal Investigator
    Matrix Metalloproteinases Gordon Conference
    NIH/NCI R13CA115182Jun 1, 2005 - May 31, 2010
    Role: Co-Principal Investigator
    Molecular and Cellular Mechanisms in Cancer
    NIH/NCI T32CA108462Sep 1, 2004 - Aug 31, 2019
    Role: Principal Investigator
    Resource for X-ray Tomography of Whole Cells
    NIH/NCRR P41RR019664May 6, 2004 - Apr 30, 2013
    Role: Co-Investigator
    Perkin Elmer Ultraview Spinning Disc Confocal Microscope
    NIH/NCRR S10RR019401Apr 1, 2004 - Mar 31, 2006
    Role: Principal Investigator
    Smoke-induced AP-1 controls mucous vs squamous phenotype
    NIH/NHLBI R01HL075602Jan 20, 2004 - Dec 31, 2008
    Role: Principal Investigator
    Matrix Metalloproteases Regulate Mesenchymal Stem Cells
    NIH/NIA R01AG023218Jul 1, 2003 - Jun 30, 2007
    Role: Principal Investigator
    Gordon Research Conference on Matrix Metalloproteinases
    NIH/NIDCR R13DE015313Jun 1, 2003 - May 31, 2004
    Role: Principal Investigator
    Role of Chloride Channels in Mucin Production
    NIH/NHLBI R01HL073309Apr 1, 2003 - Mar 31, 2007
    Role: Principal Investigator
    Mucosal Immune Barrier in Infection and Immunity
    NIH/NIAID P01AI053194Sep 30, 2002 - Aug 31, 2014
    Role: Co-Investigator
    Extracellular remodeling in bone development and repair
    NIH/NIAMS R01AR046238Sep 1, 1999 - Jan 31, 2011
    Role: Principal Investigator
    NIH/NCI R01CA075072Aug 15, 1997 - Nov 30, 2002
    Role: Principal Investigator
    Proteases in Cancer Biology and Drug Development
    NIH/NCI P01CA072006Jun 10, 1997 - Jun 30, 2010
    Role: Principal Investigator
    Role of Metalloproteinases in Mammary Gland Remodeling
    NIH/NCI R01CA057621Apr 15, 1993 - Aug 31, 2018
    Role: Principal Investigator
    NIH/NIDCR P50DE010306Dec 1, 1992 - Oct 31, 1999
    Role: Co-Investigator
    NIH/NICHD P01HD026732Feb 1, 1991 - Jan 31, 2002
    Role: Co-Investigator
    NIH/NICHD R01HD023539Feb 1, 1988 - Jan 31, 1994
    Role: Principal Investigator
    NIH/NIEHS T32ES007106Jul 1, 1982 - Jun 30, 2003
    Role: Principal Investigator
    NIH/NIAMS P60AR020684Sep 15, 1977 - Dec 31, 2003
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Global Health
    Collapse Websites
    Collapse In The News
    Collapse Featured Videos

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Takai K, Drain AP, Lawson DA, Littlepage LE, Karpuj M, Kessenbrock K, Le A, Inoue K, Weaver VM, Werb Z. Discoidin domain receptor 1 (DDR1) ablation promotes tissue fibrosis and hypoxia to induce aggressive basal-like breast cancers. Genes Dev. 2018 Feb 01; 32(3-4):244-257. PMID: 29483153.
      View in: PubMed
    2. Devignes CS, Aslan Y, Brenot A, Devillers A, Schepers K, Fabre S, Chou J, Casbon AJ, Werb Z, Provot S. HIF signaling in osteoblast-lineage cells promotes systemic breast cancer growth and metastasis in mice. Proc Natl Acad Sci U S A. 2018 Jan 16. PMID: 29339479.
      View in: PubMed
    3. Gonzalez H, Robles I, Werb Z. Innate and acquired immune surveillance in the postdissemination phase of metastasis. FEBS J. 2018 Feb; 285(4):654-664. PMID: 29131550.
      View in: PubMed
    4. Shahi P, Wang CY, Chou J, Hagerling C, Gonzalez Velozo H, Ruderisch A, Yu Y, Lai MD, Werb Z. GATA3 targets semaphorin 3B in mammary epithelial cells to suppress breast cancer progression and metastasis. Oncogene. 2017 Oct 05; 36(40):5567-5575. PMID: 28581515.
      View in: PubMed
    5. Kessenbrock K, Smith P, Steenbeek SC, Pervolarakis N, Kumar R, Minami Y, Goga A, Hinck L, Werb Z. Diverse regulation of mammary epithelial growth and branching morphogenesis through noncanonical Wnt signaling. Proc Natl Acad Sci U S A. 2017 03 21; 114(12):3121-3126. PMID: 28270600.
      View in: PubMed
    6. Shahi P, Wang CY, Lawson DA, Slorach EM, Lu A, Yu Y, Lai MD, Gonzalez Velozo H, Werb Z. ZNF503/Zpo2 drives aggressive breast cancer progression by down-regulation of GATA3 expression. Proc Natl Acad Sci U S A. 2017 03 21; 114(12):3169-3174. PMID: 28258171.
      View in: PubMed
    7. Takai K, Le A, Weaver VM, Werb Z. Targeting the cancer-associated fibroblasts as a treatment in triple-negative breast cancer. Oncotarget. 2016 Dec 13; 7(50):82889-82901. PMID: 27756881.
      View in: PubMed
    8. Wang CY, Shahi P, Huang JT, Phan NN, Sun Z, Lin YC, Lai MD, Werb Z. Systematic analysis of the achaete-scute complex-like gene signature in clinical cancer patients. Mol Clin Oncol. 2017 Jan; 6(1):7-18. PMID: 28123722.
      View in: PubMed
    9. Horiuchi D, Camarda R, Zhou AY, Yau C, Momcilovic O, Balakrishnan S, Corella AN, Eyob H, Kessenbrock K, Lawson DA, Marsh LA, Anderton BN, Rohrberg J, Kunder R, Bazarov AV, Yaswen P, McManus MT, Rugo HS, Werb Z, Goga A. PIM1 kinase inhibition as a targeted therapy against triple-negative breast tumors with elevated MYC expression. Nat Med. 2016 11; 22(11):1321-1329. PMID: 27775705.
      View in: PubMed
    10. Allaoui R, Bergenfelz C, Mohlin S, Hagerling C, Salari K, Werb Z, Anderson RL, Ethier SP, Jirström K, Påhlman S, Bexell D, Tahin B, Johansson ME, Larsson C, Leandersson K. Cancer-associated fibroblast-secreted CXCL16 attracts monocytes to promote stroma activation in triple-negative breast cancers. Nat Commun. 2016 Oct 11; 7:13050. PMID: 27725631.
      View in: PubMed
    11. Trivedi A, Zhang H, Ekeledo A, Lee S, Werb Z, Plant GW, Noble-Haeusslein LJ. Deficiency in matrix metalloproteinase-2 results in long-term vascular instability and regression in the injured mouse spinal cord. Exp Neurol. 2016 Oct; 284(Pt A):50-62. PMID: 27468657.
      View in: PubMed
    12. Chou J, Chan MF, Werb Z. Metalloproteinases: a Functional Pathway for Myeloid Cells. Microbiol Spectr. 2016 04; 4(2). PMID: 27227311; PMCID: PMC4888795.
    13. Hagerling C, Werb Z. Neutrophils: Critical components in experimental animal models of cancer. Semin Immunol. 2016 04; 28(2):197-204. PMID: 26976824.
      View in: PubMed
    14. Williams KE, Lemieux GA, Hassis ME, Olshen AB, Fisher SJ, Werb Z. Quantitative proteomic analyses of mammary organoids reveals distinct signatures after exposure to environmental chemicals. Proc Natl Acad Sci U S A. 2016 Mar 08; 113(10):E1343-51. PMID: 26903627; PMCID: PMC4790982.
    15. Lawson DA, Werb Z, Zong Y, Goldstein AS. The Cleared Mammary Fat Pad Transplantation Assay for Mammary Epithelial Organogenesis. Cold Spring Harb Protoc. 2015 Dec 02; 2015(12):pdb.prot078071. PMID: 26631119; PMCID: PMC4965229 [Available on 12/02/16].
    16. Kim M, M Shewan A, Ewald AJ, Werb Z, Mostov KE. p114RhoGEF governs cell motility and lumen formation during tubulogenesis through a ROCK-myosin-II pathway. J Cell Sci. 2015 Dec 01; 128(23):4317-27. PMID: 26483385; PMCID: PMC4712812 [Available on 12/01/16].
    17. Lawson DA, Bhakta NR, Kessenbrock K, Prummel KD, Yu Y, Takai K, Zhou A, Eyob H, Balakrishnan S, Wang CY, Yaswen P, Goga A, Werb Z. Single-cell analysis reveals a stem-cell program in human metastatic breast cancer cells. Nature. 2015 Oct 01; 526(7571):131-5. PMID: 26416748; PMCID: PMC4648562.
    18. Plaks V, Boldajipour B, Linnemann JR, Nguyen NH, Kersten K, Wolf Y, Casbon AJ, Kong N, van den Bijgaart RJ, Sheppard D, Melton AC, Krummel MF, Werb Z. Adaptive Immune Regulation of Mammary Postnatal Organogenesis. Dev Cell. 2015 Sep 14; 34(5):493-504. PMID: 26321127; PMCID: PMC4573906.
    19. Sun Z, Lawson DA, Sinclair E, Wang CY, Lai MD, Hetts SW, Higashida RT, Dowd CF, Halbach VV, Werb Z, Su H, Cooke DL. Endovascular biopsy: Strategy for analyzing gene expression profiles of individual endothelial cells obtained from human vessels?. Biotechnol Rep (Amst). 2015 Sep; 7:157-165. PMID: 26989654.
      View in: PubMed
    20. Chan MF, Werb Z. Animal Models of Corneal Injury. Bio Protoc. 2015 Jul 05; 5(13):e1516. PMID: 26191536.
      View in: PubMed
    21. Chan MF, Werb Z. Confocal Imaging of Myeloid Cells in the Corneal Stroma of Live Mice. Bio Protoc. 2015 Jul 05; 5(13):e1517. PMID: 26191537.
      View in: PubMed
    22. Werb Z, Lu P. The Role of Stroma in Tumor Development. Cancer J. 2015 Jul-Aug; 21(4):250-3. PMID: 26222075; PMCID: PMC4963227.
    23. Depeille P, Henricks LM, van de Ven RA, Lemmens E, Wang CY, Matli M, Werb Z, Haigis KM, Donner D, Warren R, Roose JP. RasGRP1 opposes proliferative EGFR-SOS1-Ras signals and restricts intestinal epithelial cell growth. Nat Cell Biol. 2015 Jun; 17(6):804-15. PMID: 26005835; PMCID: PMC4652934.
    24. Chambers AF, Werb Z. Invasion and metastasis--recent advances and future challenges. J Mol Med (Berl). 2015 Apr; 93(4):361-8. PMID: 25772709.
      View in: PubMed
    25. Plaks V, Kong N, Werb Z. The cancer stem cell niche: how essential is the niche in regulating stemness of tumor cells? Cell Stem Cell. 2015 Mar 05; 16(3):225-38. PMID: 25748930; PMCID: PMC4355577.
    26. Casbon AJ, Lohela M, Werb Z. Delineating CSF-1-dependent regulation of myeloid cell diversity in tumors. Oncoimmunology. 2015 Jun; 4(6):e1008871. PMID: 26155427.
      View in: PubMed
    27. Kessenbrock K, Wang CY, Werb Z. Matrix metalloproteinases in stem cell regulation and cancer. Matrix Biol. 2015 May-Jul; 44-46:184-90. PMID: 25661772; PMCID: PMC4498798.
    28. Casbon AJ, Reynaud D, Park C, Khuc E, Gan DD, Schepers K, Passegué E, Werb Z. Invasive breast cancer reprograms early myeloid differentiation in the bone marrow to generate immunosuppressive neutrophils. Proc Natl Acad Sci U S A. 2015 Feb 10; 112(6):E566-75. PMID: 25624500; PMCID: PMC4330753.
    29. Lemieux GA, Cunningham KA, Lin L, Mayer F, Werb Z, Ashrafi K. Kynurenic acid is a nutritional cue that enables behavioral plasticity. Cell. 2015 Jan 15; 160(1-2):119-31. PMID: 25594177; PMCID: PMC4334586.
    30. Shahi P, Slorach EM, Wang CY, Chou J, Lu A, Ruderisch A, Werb Z. The Transcriptional Repressor ZNF503/Zeppo2 Promotes Mammary Epithelial Cell Proliferation and Enhances Cell Invasion. J Biol Chem. 2015 Feb 06; 290(6):3803-13. PMID: 25538248; PMCID: PMC4319044.
    31. Bonnans C, Chou J, Werb Z. Remodelling the extracellular matrix in development and disease. Nat Rev Mol Cell Biol. 2014 Dec; 15(12):786-801. PMID: 25415508; PMCID: PMC4316204.
    32. Hagerling C, Casbon AJ, Werb Z. Balancing the innate immune system in tumor development. Trends Cell Biol. 2015 Apr; 25(4):214-20. PMID: 25444276; PMCID: PMC4380818.
    33. Lohela M, Casbon AJ, Olow A, Bonham L, Branstetter D, Weng N, Smith J, Werb Z. Intravital imaging reveals distinct responses of depleting dynamic tumor-associated macrophage and dendritic cell subpopulations. Proc Natl Acad Sci U S A. 2014 Nov 25; 111(47):E5086-95. PMID: 25385645; PMCID: PMC4250128.
    34. Bryant DM, Roignot J, Datta A, Overeem AW, Kim M, Yu W, Peng X, Eastburn DJ, Ewald AJ, Werb Z, Mostov KE. A molecular switch for the orientation of epithelial cell polarization. Dev Cell. 2014 Oct 27; 31(2):171-87. PMID: 25307480; PMCID: PMC4248238.
    35. Bonnans C, Lohela M, Werb Z. Real-time imaging of myeloid cells dynamics in ApcMin/+ intestinal tumors by spinning disk confocal microscopy. J Vis Exp. 2014 Oct 06; (92):51916. PMID: 25350573; PMCID: PMC4318091.
    36. Hiatt RA, Porco TC, Liu F, Balke K, Balmain A, Barlow J, Braithwaite D, Diez-Roux AV, Kushi LH, Moasser MM, Werb Z, Windham GC, Rehkopf DH. A multilevel model of postmenopausal breast cancer incidence. Cancer Epidemiol Biomarkers Prev. 2014 Oct; 23(10):2078-92. PMID: 25017248.
      View in: PubMed
    37. Levine JM, Cohen ND, Heller M, Fajt VR, Levine GJ, Kerwin SC, Trivedi AA, Fandel TM, Werb Z, Modestino A, Noble-Haeusslein LJ. Efficacy of a metalloproteinase inhibitor in spinal cord injured dogs. PLoS One. 2014; 9(5):e96408. PMID: 24788791; PMCID: PMC4006832.
    38. Cheung KJ, Gabrielson E, Werb Z, Ewald AJ. Collective invasion in breast cancer requires a conserved basal epithelial program. Cell. 2013 Dec 19; 155(7):1639-51. PMID: 24332913; PMCID: PMC3941206.
    39. Lemieux GA, Keiser MJ, Sassano MF, Laggner C, Mayer F, Bainton RJ, Werb Z, Roth BL, Shoichet BK, Ashrafi K. In silico molecular comparisons of C. elegans and mammalian pharmacology identify distinct targets that regulate feeding. PLoS Biol. 2013 Nov; 11(11):e1001712. PMID: 24260022; PMCID: PMC3833878.
    40. Plaks V, Koopman CD, Werb Z. Cancer. Circulating tumor cells. Science. 2013 Sep 13; 341(6151):1186-8. PMID: 24031008; PMCID: PMC3842225.
    41. Brabletz T, Lyden D, Steeg PS, Werb Z. Roadblocks to translational advances on metastasis research. Nat Med. 2013 Sep; 19(9):1104-9. PMID: 24013756; PMCID: PMC3972758.
    42. Chou J, Shahi P, Werb Z. microRNA-mediated regulation of the tumor microenvironment. Cell Cycle. 2013 Oct 15; 12(20):3262-71. PMID: 24036551; PMCID: PMC3885637.
    43. Kessenbrock K, Dijkgraaf GJ, Lawson DA, Littlepage LE, Shahi P, Pieper U, Werb Z. A role for matrix metalloproteinases in regulating mammary stem cell function via the Wnt signaling pathway. Cell Stem Cell. 2013 Sep 05; 13(3):300-13. PMID: 23871604; PMCID: PMC3769456.
    44. Chan MF, Li J, Bertrand A, Casbon AJ, Lin JH, Maltseva I, Werb Z. Protective effects of matrix metalloproteinase-12 following corneal injury. J Cell Sci. 2013 Sep 01; 126(Pt 17):3948-60. PMID: 23813962; PMCID: PMC3757333.
    45. Plaks V, Rinkenberger J, Dai J, Flannery M, Sund M, Kanasaki K, Ni W, Kalluri R, Werb Z. Matrix metalloproteinase-9 deficiency phenocopies features of preeclampsia and intrauterine growth restriction. Proc Natl Acad Sci U S A. 2013 Jul 02; 110(27):11109-14. PMID: 23776237; PMCID: PMC3704020.
    46. Morrisey EE, Cardoso WV, Lane RH, Rabinovitch M, Abman SH, Ai X, Albertine KH, Bland RD, Chapman HA, Checkley W, Epstein JA, Kintner CR, Kumar M, Minoo P, Mariani TJ, McDonald DM, Mukouyama YS, Prince LS, Reese J, Rossant J, Shi W, Sun X, Werb Z, Whitsett JA, Gail D, Blaisdell CJ, Lin QS. Molecular determinants of lung development. Ann Am Thorac Soc. 2013 Apr; 10(2):S12-6. PMID: 23607856.
      View in: PubMed
    47. Chou J, Lin JH, Brenot A, Kim JW, Provot S, Werb Z. GATA3 suppresses metastasis and modulates the tumour microenvironment by regulating microRNA-29b expression. Nat Cell Biol. 2013 Feb; 15(2):201-13. PMID: 23354167; PMCID: PMC3660859.
    48. Plaks V, Brenot A, Lawson DA, Linnemann JR, Van Kappel EC, Wong KC, de Sauvage F, Klein OD, Werb Z. Lgr5-expressing cells are sufficient and necessary for postnatal mammary gland organogenesis. Cell Rep. 2013 Jan 31; 3(1):70-8. PMID: 23352663; PMCID: PMC3563842.
    49. Chou J, Werb Z. MicroRNAs play a big role in regulating ovarian cancer-associated fibroblasts and the tumor microenvironment. Cancer Discov. 2012 Dec; 2(12):1078-80. PMID: 23230184; PMCID: PMC3531831.
    50. Wang X, Yu YY, Lieu S, Yang F, Lang J, Lu C, Werb Z, Hu D, Miclau T, Marcucio R, Colnot C. MMP9 regulates the cellular response to inflammation after skeletal injury. Bone. 2013 Jan; 52(1):111-9. PMID: 23010105; PMCID: PMC3513654.
    51. Nguyen-Ngoc KV, Cheung KJ, Brenot A, Shamir ER, Gray RS, Hines WC, Yaswen P, Werb Z, Ewald AJ. ECM microenvironment regulates collective migration and local dissemination in normal and malignant mammary epithelium. Proc Natl Acad Sci U S A. 2012 Sep 25; 109(39):E2595-604. PMID: 22923691; PMCID: PMC3465416.
    52. Caudrillier A, Kessenbrock K, Gilliss BM, Nguyen JX, Marques MB, Monestier M, Toy P, Werb Z, Looney MR. Platelets induce neutrophil extracellular traps in transfusion-related acute lung injury. J Clin Invest. 2012 Jul; 122(7):2661-71. PMID: 22684106; PMCID: PMC3386815.
    53. Littlepage LE, Adler AS, Kouros-Mehr H, Huang G, Chou J, Krig SR, Griffith OL, Korkola JE, Qu K, Lawson DA, Xue Q, Sternlicht MD, Dijkgraaf GJ, Yaswen P, Rugo HS, Sweeney CA, Collins CC, Gray JW, Chang HY, Werb Z. The transcription factor ZNF217 is a prognostic biomarker and therapeutic target during breast cancer progression. Cancer Discov. 2012 Jul; 2(7):638-51. PMID: 22728437; PMCID: PMC3546490.
    54. Nakasone ES, Askautrud HA, Kees T, Park JH, Plaks V, Ewald AJ, Fein M, Rasch MG, Tan YX, Qiu J, Park J, Sinha P, Bissell MJ, Frengen E, Werb Z, Egeblad M. Imaging tumor-stroma interactions during chemotherapy reveals contributions of the microenvironment to resistance. Cancer Cell. 2012 Apr 17; 21(4):488-503. PMID: 22516258; PMCID: PMC3332002.
    55. Engelhardt JJ, Boldajipour B, Beemiller P, Pandurangi P, Sorensen C, Werb Z, Egeblad M, Krummel MF. Marginating dendritic cells of the tumor microenvironment cross-present tumor antigens and stably engage tumor-specific T cells. Cancer Cell. 2012 Mar 20; 21(3):402-17. PMID: 22439936; PMCID: PMC3311997.
    56. Lu P, Weaver VM, Werb Z. The extracellular matrix: a dynamic niche in cancer progression. J Cell Biol. 2012 Feb 20; 196(4):395-406. PMID: 22351925; PMCID: PMC3283993.
    57. Ewald AJ, Huebner RJ, Palsdottir H, Lee JK, Perez MJ, Jorgens DM, Tauscher AN, Cheung KJ, Werb Z, Auer M. Mammary collective cell migration involves transient loss of epithelial features and individual cell migration within the epithelium. J Cell Sci. 2012 Jun 01; 125(Pt 11):2638-54. PMID: 22344263; PMCID: PMC3403234.
    58. Phillips JJ, Huillard E, Robinson AE, Ward A, Lum DH, Polley MY, Rosen SD, Rowitch DH, Werb Z. Heparan sulfate sulfatase SULF2 regulates PDGFRa signaling and growth in human and mouse malignant glioma. J Clin Invest. 2012 Mar; 122(3):911-22. PMID: 22293178; PMCID: PMC3287216.
    59. Partanen JI, Tervonen TA, Myllynen M, Lind E, Imai M, Katajisto P, Dijkgraaf GJ, Kovanen PE, Mäkelä TP, Werb Z, Klefström J. Tumor suppressor function of Liver kinase B1 (Lkb1) is linked to regulation of epithelial integrity. Proc Natl Acad Sci U S A. 2012 Feb 14; 109(7):E388-97. PMID: 22308451; PMCID: PMC3289385.
    60. Lu P, Takai K, Weaver VM, Werb Z. Extracellular matrix degradation and remodeling in development and disease. Cold Spring Harb Perspect Biol. 2011 Dec 01; 3(12). PMID: 21917992; PMCID: PMC3225943.
    61. Zhang H, Trivedi A, Lee JU, Lohela M, Lee SM, Fandel TM, Werb Z, Noble-Haeusslein LJ. Matrix metalloproteinase-9 and stromal cell-derived factor-1 act synergistically to support migration of blood-borne monocytes into the injured spinal cord. J Neurosci. 2011 Nov 02; 31(44):15894-903. PMID: 22049432; PMCID: PMC3265932.
    62. Lin L, Bankaitis E, Heimbach L, Li N, Abrink M, Pejler G, An L, Diaz LA, Werb Z, Liu Z. Dual targets for mouse mast cell protease-4 in mediating tissue damage in experimental bullous pemphigoid. J Biol Chem. 2011 Oct 28; 286(43):37358-67. PMID: 21880713; PMCID: PMC3199483.
    63. Hong JS, Greenlee KJ, Pitchumani R, Lee SH, Song LZ, Shan M, Chang SH, Park PW, Dong C, Werb Z, Bidani A, Corry DB, Kheradmand F. Dual protective mechanisms of matrix metalloproteinases 2 and 9 in immune defense against Streptococcus pneumoniae. J Immunol. 2011 Jun 01; 186(11):6427-36. PMID: 21508260; PMCID: PMC3546495.
    64. Khokha R, Werb Z. Mammary gland reprogramming: metalloproteinases couple form with function. Cold Spring Harb Perspect Biol. 2011 Apr 01; 3(4). PMID: 21106646; PMCID: PMC3062217.
    65. Kessenbrock K, Brown M, Werb Z. Measuring matrix metalloproteinase activity in macrophages and polymorphonuclear leukocytes. Curr Protoc Immunol. 2011 Apr; Chapter 14:Unit14.24. PMID: 21462166; PMCID: PMC3538162.
    66. Lemieux GA, Liu J, Mayer N, Bainton RJ, Ashrafi K, Werb Z. A whole-organism screen identifies new regulators of fat storage. Nat Chem Biol. 2011 Apr; 7(4):206-13. PMID: 21390037; PMCID: PMC3076723.
    67. Slorach EM, Chou J, Werb Z. Zeppo1 is a novel metastasis promoter that represses E-cadherin expression and regulates p120-catenin isoform expression and localization. Genes Dev. 2011 Mar 01; 25(5):471-84. PMID: 21317240; PMCID: PMC3049288.
    68. Ewald AJ, Werb Z, Egeblad M. Dynamic, long-term in vivo imaging of tumor-stroma interactions in mouse models of breast cancer using spinning-disk confocal microscopy. Cold Spring Harb Protoc. 2011 Feb 01; 2011(2):pdb.top97. PMID: 21285277; PMCID: PMC3533368.
    69. Ewald AJ, Werb Z, Egeblad M. Monitoring of vital signs for long-term survival of mice under anesthesia. Cold Spring Harb Protoc. 2011 Feb 01; 2011(2):pdb.prot5563. PMID: 21285263; PMCID: PMC3531964.
    70. Ewald AJ, Werb Z, Egeblad M. Preparation of mice for long-term intravital imaging of the mammary gland. Cold Spring Harb Protoc. 2011 Feb 01; 2011(2):pdb.prot5562. PMID: 21285262; PMCID: PMC3531961.
    71. Lieu S, Hansen E, Dedini R, Behonick D, Werb Z, Miclau T, Marcucio R, Colnot C. Impaired remodeling phase of fracture repair in the absence of matrix metalloproteinase-2. Dis Model Mech. 2011 Mar; 4(2):203-11. PMID: 21135056; PMCID: PMC3046093.
    72. Pozniak CD, Langseth AJ, Dijkgraaf GJ, Choe Y, Werb Z, Pleasure SJ. Sox10 directs neural stem cells toward the oligodendrocyte lineage by decreasing Suppressor of Fused expression. Proc Natl Acad Sci U S A. 2010 Dec 14; 107(50):21795-800. PMID: 21098272; PMCID: PMC3003047.
    73. Werb Z. The joy of a career in cell biology. Mol Biol Cell. 2010 Nov 15; 21(22):3764-6. PMID: 21079003; PMCID: PMC2982121.
    74. Werb Z. The extracellular matrix and disease: An interview with Zena Werb. Interviewed by Kristin H. Kain. Dis Model Mech. 2010 Sep-Oct; 3(9-10):513-6. PMID: 20699476.
      View in: PubMed
    75. Egeblad M, Nakasone ES, Werb Z. Tumors as organs: complex tissues that interface with the entire organism. Dev Cell. 2010 Jun 15; 18(6):884-901. PMID: 20627072; PMCID: PMC2905377.
    76. Kessenbrock K, Plaks V, Werb Z. Matrix metalloproteinases: regulators of the tumor microenvironment. Cell. 2010 Apr 02; 141(1):52-67. PMID: 20371345; PMCID: PMC2862057.
    77. Zhang H, Adwanikar H, Werb Z, Noble-Haeusslein LJ. Matrix metalloproteinases and neurotrauma: evolving roles in injury and reparative processes. Neuroscientist. 2010 Apr; 16(2):156-70. PMID: 20400713; PMCID: PMC2858362.
    78. Sounni NE, Dehne K, van Kempen L, Egeblad M, Affara NI, Cuevas I, Wiesen J, Junankar S, Korets L, Lee J, Shen J, Morrison CJ, Overall CM, Krane SM, Werb Z, Boudreau N, Coussens LM. Stromal regulation of vessel stability by MMP14 and TGFbeta. Dis Model Mech. 2010 May-Jun; 3(5-6):317-32. PMID: 20223936; PMCID: PMC2860851.
    79. Littlepage LE, Sternlicht MD, Rougier N, Phillips J, Gallo E, Yu Y, Williams K, Brenot A, Gordon JI, Werb Z. Matrix metalloproteinases contribute distinct roles in neuroendocrine prostate carcinogenesis, metastasis, and angiogenesis progression. Cancer Res. 2010 Mar 15; 70(6):2224-34. PMID: 20215503; PMCID: PMC2840052.
    80. Ortega N, Wang K, Ferrara N, Werb Z, Vu TH. Complementary interplay between matrix metalloproteinase-9, vascular endothelial growth factor and osteoclast function drives endochondral bone formation. Dis Model Mech. 2010 Mar-Apr; 3(3-4):224-35. PMID: 20142327; PMCID: PMC2869494.
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    83. Little CB, Barai A, Burkhardt D, Smith SM, Fosang AJ, Werb Z, Shah M, Thompson EW. Matrix metalloproteinase 13-deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development. Arthritis Rheum. 2009 Dec; 60(12):3723-33. PMID: 19950295; PMCID: PMC2832925.
    84. Lohela M, Werb Z. Intravital imaging of stromal cell dynamics in tumors. Curr Opin Genet Dev. 2010 Feb; 20(1):72-8. PMID: 19942428; PMCID: PMC2821950.
    85. Lederle W, Hartenstein B, Meides A, Kunzelmann H, Werb Z, Angel P, Mueller MM. MMP13 as a stromal mediator in controlling persistent angiogenesis in skin carcinoma. Carcinogenesis. 2010 Jul; 31(7):1175-84. PMID: 19892798; PMCID: PMC2893794.
    86. Atabai K, Jame S, Azhar N, Kuo A, Lam M, McKleroy W, Dehart G, Rahman S, Xia DD, Melton AC, Wolters P, Emson CL, Turner SM, Werb Z, Sheppard D. Mfge8 diminishes the severity of tissue fibrosis in mice by binding and targeting collagen for uptake by macrophages. J Clin Invest. 2009 Dec; 119(12):3713-22. PMID: 19884654; PMCID: PMC2786804.
    87. Lilla JN, Werb Z. Mast cells contribute to the stromal microenvironment in mammary gland branching morphogenesis. Dev Biol. 2010 Jan 01; 337(1):124-33. PMID: 19850030; PMCID: PMC2787992.
    88. Kessenbrock K, Krumbholz M, Schönermarck U, Back W, Gross WL, Werb Z, Gröne HJ, Brinkmann V, Jenne DE. Netting neutrophils in autoimmune small-vessel vasculitis. Nat Med. 2009 Jun; 15(6):623-5. PMID: 19448636; PMCID: PMC2760083.
    89. Bengatta S, Arnould C, Letavernier E, Monge M, de Préneuf HM, Werb Z, Ronco P, Lelongt B. MMP9 and SCF protect from apoptosis in acute kidney injury. J Am Soc Nephrol. 2009 Apr; 20(4):787-97. PMID: 19329763; PMCID: PMC2663840.
    90. Lilla JN, Joshi RV, Craik CS, Werb Z. Active plasma kallikrein localizes to mast cells and regulates epithelial cell apoptosis, adipocyte differentiation, and stromal remodeling during mammary gland involution. J Biol Chem. 2009 May 15; 284(20):13792-803. PMID: 19297327; PMCID: PMC2679480.
    91. Hsu JY, Bourguignon LY, Adams CM, Peyrollier K, Zhang H, Fandel T, Cun CL, Werb Z, Noble-Haeusslein LJ. Matrix metalloproteinase-9 facilitates glial scar formation in the injured spinal cord. J Neurosci. 2008 Dec 10; 28(50):13467-77. PMID: 19074020; PMCID: PMC2712293.
    92. Fernandez-Gonzalez R, Illa-Bochaca I, Welm BE, Fleisch MC, Werb Z, Ortiz-de-Solorzano C, Barcellos-Hoff MH. Mapping mammary gland architecture using multi-scale in situ analysis. Integr Biol (Camb). 2009 Jan; 1(1):80-9. PMID: 20023794; PMCID: PMC2847439.
    93. Lu P, Werb Z. Patterning mechanisms of branched organs. Science. 2008 Dec 05; 322(5907):1506-9. PMID: 19056977; PMCID: PMC2645229.
    94. Egeblad M, Ewald AJ, Askautrud HA, Truitt ML, Welm BE, Bainbridge E, Peeters G, Krummel MF, Werb Z. Visualizing stromal cell dynamics in different tumor microenvironments by spinning disk confocal microscopy. Dis Model Mech. 2008 Sep-Oct; 1(2-3):155-67; discussion 165. PMID: 19048079; PMCID: PMC2562195.
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    100. Lu P, Yu Y, Perdue Y, Werb Z. The apical ectodermal ridge is a timer for generating distal limb progenitors. Development. 2008 Apr; 135(8):1395-405. PMID: 18359901; PMCID: PMC2574509.
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    102. Du R, Lu KV, Petritsch C, Liu P, Ganss R, Passegué E, Song H, Vandenberg S, Johnson RS, Werb Z, Bergers G. HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion. Cancer Cell. 2008 Mar; 13(3):206-20. PMID: 18328425; PMCID: PMC2643426.
    103. Kouros-Mehr H, Bechis SK, Slorach EM, Littlepage LE, Egeblad M, Ewald AJ, Pai SY, Ho IC, Werb Z. GATA-3 links tumor differentiation and dissemination in a luminal breast cancer model. Cancer Cell. 2008 Feb; 13(2):141-52. PMID: 18242514; PMCID: PMC2262951.
    104. Adler AS, Littlepage LE, Lin M, Kawahara TL, Wong DJ, Werb Z, Chang HY. CSN5 isopeptidase activity links COP9 signalosome activation to breast cancer progression. Cancer Res. 2008 Jan 15; 68(2):506-15. PMID: 18199546; PMCID: PMC2646416.
    105. Welm BE, Dijkgraaf GJ, Bledau AS, Welm AL, Werb Z. Lentiviral transduction of mammary stem cells for analysis of gene function during development and cancer. Cell Stem Cell. 2008 Jan 10; 2(1):90-102. PMID: 18371425; PMCID: PMC2276651.
    106. Heissig B, Lund LR, Akiyama H, Ohki M, Morita Y, Rømer J, Nakauchi H, Okumura K, Ogawa H, Werb Z, Danø K, Hattori K. The plasminogen fibrinolytic pathway is required for hematopoietic regeneration. Cell Stem Cell. 2007 Dec 13; 1(6):658-70. PMID: 18371407; PMCID: PMC2646407.
    107. Sneddon JB, Werb Z. Location, location, location: the cancer stem cell niche. Cell Stem Cell. 2007 Dec 13; 1(6):607-11. PMID: 18371402; PMCID: PMC2571117.
    108. Melani C, Sangaletti S, Barazzetta FM, Werb Z, Colombo MP. Amino-biphosphonate-mediated MMP-9 inhibition breaks the tumor-bone marrow axis responsible for myeloid-derived suppressor cell expansion and macrophage infiltration in tumor stroma. Cancer Res. 2007 Dec 01; 67(23):11438-46. PMID: 18056472; PMCID: PMC2646404.
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    113. Lemieux GA, Blumenkron F, Yeung N, Zhou P, Williams J, Grammer AC, Petrovich R, Lipsky PE, Moss ML, Werb Z. The low affinity IgE receptor (CD23) is cleaved by the metalloproteinase ADAM10. J Biol Chem. 2007 May 18; 282(20):14836-44. PMID: 17389606; PMCID: PMC2582392.
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    117. Yu W, Fang X, Ewald A, Wong K, Hunt CA, Werb Z, Matthay MA, Mostov K. Formation of cysts by alveolar type II cells in three-dimensional culture reveals a novel mechanism for epithelial morphogenesis. Mol Biol Cell. 2007 May; 18(5):1693-700. PMID: 17332496; PMCID: PMC1855040.
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    120. Yeh MW, Rougier JP, Park JW, Duh QY, Wong M, Werb Z, Clark OH. Differentiated thyroid cancer cell invasion is regulated through epidermal growth factor receptor-dependent activation of matrix metalloproteinase (MMP)-2/gelatinase A. Endocr Relat Cancer. 2006 Dec; 13(4):1173-83. PMID: 17158762; PMCID: PMC2574514.
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    125. Sternlicht MD, Dunning AM, Moore DH, Pharoah PD, Ginzinger DG, Chin K, Gray JW, Waldman FM, Ponder BA, Werb Z. Prognostic value of PAI1 in invasive breast cancer: evidence that tumor-specific factors are more important than genetic variation in regulating PAI1 expression. Cancer Epidemiol Biomarkers Prev. 2006 Nov; 15(11):2107-14. PMID: 17119035; PMCID: PMC2731792.
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    161. Man AK, Young LJ, Tynan JA, Lesperance J, Egeblad M, Werb Z, Hauser CA, Muller WJ, Cardiff RD, Oshima RG. Ets2-dependent stromal regulation of mouse mammary tumors. Mol Cell Biol. 2003 Dec; 23(23):8614-25. PMID: 14612405; PMCID: PMC262691.
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    170. Luk HW, Noble LJ, Werb Z. Macrophages contribute to the maintenance of stable regenerating neurites following peripheral nerve injury. J Neurosci Res. 2003 Sep 01; 73(5):644-58. PMID: 12929132; PMCID: PMC2792202.
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    172. Fata JE, Werb Z, Bissell MJ. Regulation of mammary gland branching morphogenesis by the extracellular matrix and its remodeling enzymes. Breast Cancer Res. 2004; 6(1):1-11. PMID: 14680479; PMCID: PMC314442.
    173. Slorach EM, Werb Z. Epithelial morphogenesis: Netrin comes to a sticky and terminal end. Curr Biol. 2003 Jun 17; 13(12):R491-3. PMID: 12814570.
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    174. Hamano Y, Zeisberg M, Sugimoto H, Lively JC, Maeshima Y, Yang C, Hynes RO, Werb Z, Sudhakar A, Kalluri R. Physiological levels of tumstatin, a fragment of collagen IV alpha3 chain, are generated by MMP-9 proteolysis and suppress angiogenesis via alphaV beta3 integrin. Cancer Cell. 2003 Jun; 3(6):589-601. PMID: 12842087; PMCID: PMC2775452.
    175. Gustafsson E, Aszodi A, Ortega N, Hunziker EB, Denker HW, Werb Z, Fassler R. Role of collagen type II and perlecan in skeletal development. Ann N Y Acad Sci. 2003 May; 995:140-50. PMID: 12814946.
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    176. Ortega N, Behonick D, Stickens D, Werb Z. How proteases regulate bone morphogenesis. Ann N Y Acad Sci. 2003 May; 995:109-16. PMID: 12814943.
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    178. Vu TH, Alemayehu Y, Werb Z. New insights into saccular development and vascular formation in lung allografts under the renal capsule. Mech Dev. 2003 Mar; 120(3):305-13. PMID: 12591600; PMCID: PMC2774927.
    179. Affolter M, Bellusci S, Itoh N, Shilo B, Thiery JP, Werb Z. Tube or not tube: remodeling epithelial tissues by branching morphogenesis. Dev Cell. 2003 Jan; 4(1):11-8. PMID: 12530959.
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    180. Coussens LM, Werb Z. Inflammation and cancer. Nature. 2002 Dec 19-26; 420(6917):860-7. PMID: 12490959; PMCID: PMC2803035.
    181. Ortega N, Werb Z. New functional roles for non-collagenous domains of basement membrane collagens. J Cell Sci. 2002 Nov 15; 115(Pt 22):4201-14. PMID: 12376553; PMCID: PMC2789001.
    182. Morimoto-Tomita M, Uchimura K, Werb Z, Hemmerich S, Rosen SD. Cloning and characterization of two extracellular heparin-degrading endosulfatases in mice and humans. J Biol Chem. 2002 Dec 20; 277(51):49175-85. PMID: 12368295; PMCID: PMC2779716.
    183. Hangai M, Kitaya N, Xu J, Chan CK, Kim JJ, Werb Z, Ryan SJ, Brooks PC. Matrix metalloproteinase-9-dependent exposure of a cryptic migratory control site in collagen is required before retinal angiogenesis. Am J Pathol. 2002 Oct; 161(4):1429-37. PMID: 12368215; PMCID: PMC1867273.
    184. Lambert V, Munaut C, Jost M, Noël A, Werb Z, Foidart JM, Rakic JM. Matrix metalloproteinase-9 contributes to choroidal neovascularization. Am J Pathol. 2002 Oct; 161(4):1247-53. PMID: 12368198; PMCID: PMC1867305.
    185. Weaver VM, Lelièvre S, Lakins JN, Chrenek MA, Jones JC, Giancotti F, Werb Z, Bissell MJ. beta4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium. Cancer Cell. 2002 Sep; 2(3):205-16. PMID: 12242153; PMCID: PMC2788997.
    186. Noble LJ, Donovan F, Igarashi T, Goussev S, Werb Z. Matrix metalloproteinases limit functional recovery after spinal cord injury by modulation of early vascular events. J Neurosci. 2002 Sep 01; 22(17):7526-35. PMID: 12196576; PMCID: PMC2792199.
    187. Yan Y, Shirakabe K, Werb Z. The metalloprotease Kuzbanian (ADAM10) mediates the transactivation of EGF receptor by G protein-coupled receptors. J Cell Biol. 2002 Jul 22; 158(2):221-6. PMID: 12119356; PMCID: PMC2173139.
    188. Werner E, Werb Z. Integrins engage mitochondrial function for signal transduction by a mechanism dependent on Rho GTPases. J Cell Biol. 2002 Jul 22; 158(2):357-68. PMID: 12119354; PMCID: PMC2173123.
    189. Hattori K, Heissig B, Wu Y, Dias S, Tejada R, Ferris B, Hicklin DJ, Zhu Z, Bohlen P, Witte L, Hendrikx J, Hackett NR, Crystal RG, Moore MA, Werb Z, Lyden D, Rafii S. Placental growth factor reconstitutes hematopoiesis by recruiting VEGFR1(+) stem cells from bone-marrow microenvironment. Nat Med. 2002 Aug; 8(8):841-9. PMID: 12091880; PMCID: PMC2779715.
    190. Heissig B, Hattori K, Dias S, Friedrich M, Ferris B, Hackett NR, Crystal RG, Besmer P, Lyden D, Moore MA, Werb Z, Rafii S. Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of kit-ligand. Cell. 2002 May 31; 109(5):625-37. PMID: 12062105; PMCID: PMC2826110.
    191. Wiseman BS, Werb Z. Stromal effects on mammary gland development and breast cancer. Science. 2002 May 10; 296(5570):1046-9. PMID: 12004111; PMCID: PMC2788989.
    192. Lilla J, Stickens D, Werb Z. Metalloproteases and adipogenesis: a weighty subject. Am J Pathol. 2002 May; 160(5):1551-4. PMID: 12000705; PMCID: PMC1850859.
    193. Welm B, Mott J, Werb Z. Developmental biology: vasculogenesis is a wreck without RECK. Curr Biol. 2002 Mar 19; 12(6):R209-11. PMID: 11909548.
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    194. Corry DB, Rishi K, Kanellis J, Kiss A, Song Lz LZ, Xu J, Feng L, Werb Z, Kheradmand F. Decreased allergic lung inflammatory cell egression and increased susceptibility to asphyxiation in MMP2-deficiency. Nat Immunol. 2002 Apr; 3(4):347-53. PMID: 11887181; PMCID: PMC2814346.
    195. Egeblad M, Werb Z. New functions for the matrix metalloproteinases in cancer progression. Nat Rev Cancer. 2002 Mar; 2(3):161-74. PMID: 11990853.
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    196. Kheradmand F, Rishi K, Werb Z. Signaling through the EGF receptor controls lung morphogenesis in part by regulating MT1-MMP-mediated activation of gelatinase A/MMP2. J Cell Sci. 2002 Feb 15; 115(Pt 4):839-48. PMID: 11865039; PMCID: PMC2788991.
    197. Kheradmand F, Werb Z. Shedding light on sheddases: role in growth and development. Bioessays. 2002 Jan; 24(1):8-12. PMID: 11782944.
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    198. Chang C, Werb Z. The many faces of metalloproteases: cell growth, invasion, angiogenesis and metastasis. Trends Cell Biol. 2001 Nov; 11(11):S37-43. PMID: 11684441; PMCID: PMC2788992.
    199. Chen R, Ning G, Zhao ML, Fleming MG, Diaz LA, Werb Z, Liu Z. Mast cells play a key role in neutrophil recruitment in experimental bullous pemphigoid. J Clin Invest. 2001 Oct; 108(8):1151-8. PMID: 11602622; PMCID: PMC209499.
    200. Werner E, Kheradmand F, Isberg RR, Werb Z. Phagocytosis mediated by Yersinia invasin induces collagenase-1 expression in rabbit synovial fibroblasts through a proinflammatory cascade. J Cell Sci. 2001 Sep; 114(Pt 18):3333-43. PMID: 11591821; PMCID: PMC2788993.
    201. Rougier N, Werb Z. Minireview: Parthenogenesis in mammals. Mol Reprod Dev. 2001 Aug; 59(4):468-74. PMID: 11468784.
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    202. Simian M, Hirai Y, Navre M, Werb Z, Lochter A, Bissell MJ. The interplay of matrix metalloproteinases, morphogens and growth factors is necessary for branching of mammary epithelial cells. Development. 2001 Aug; 128(16):3117-31. PMID: 11688561; PMCID: PMC2785713.
    203. Stoll SW, Kansra S, Peshick S, Fry DW, Leopold WR, Wiesen JF, Sibilia M, Zhang T, Werb Z, Derynck R, Wagner EF, Elder JT. Differential utilization and localization of ErbB receptor tyrosine kinases in skin compared to normal and malignant keratinocytes. Neoplasia. 2001 Jul-Aug; 3(4):339-50. PMID: 11571634; PMCID: PMC1505868.
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    205. Coussens LM, Werb Z. Inflammatory cells and cancer: think different! J Exp Med. 2001 Mar 19; 193(6):F23-6. PMID: 11257144; PMCID: PMC2193419.
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    210. Yamada E, Tobe T, Yamada H, Okamoto N, Zack DJ, Werb Z, Soloway PD, Campochiaro PA. TIMP-1 promotes VEGF-induced neovascularization in the retina. Histol Histopathol. 2001 Jan; 16(1):87-97. PMID: 11193216.
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    219. Rinkenberger J, Werb Z. The labyrinthine placenta. Nat Genet. 2000 Jul; 25(3):248-50. PMID: 10888863.
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    220. Ducharme A, Frantz S, Aikawa M, Rabkin E, Lindsey M, Rohde LE, Schoen FJ, Kelly RA, Werb Z, Libby P, Lee RT. Targeted deletion of matrix metalloproteinase-9 attenuates left ventricular enlargement and collagen accumulation after experimental myocardial infarction. J Clin Invest. 2000 Jul; 106(1):55-62. PMID: 10880048; PMCID: PMC517910.
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    224. Cunha GR, Wiesen JF, Werb Z, Young P, Hom YK, Cooke PS, Lubahn DB. Paracrine mechanisms of mouse mammary ductal growth. Adv Exp Med Biol. 2000; 480:93-7. PMID: 10959414.
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    231. Gerber HP, Vu TH, Ryan AM, Kowalski J, Werb Z, Ferrara N. VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation. Nat Med. 1999 Jun; 5(6):623-8. PMID: 10371499.
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    232. Miettinen PJ, Chin JR, Shum L, Slavkin HC, Shuler CF, Derynck R, Werb Z. Epidermal growth factor receptor function is necessary for normal craniofacial development and palate closure. Nat Genet. 1999 May; 22(1):69-73. PMID: 10319864.
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    246. Yamamoto H, Flannery ML, Kupriyanov S, Pearce J, McKercher SR, Henkel GW, Maki RA, Werb Z, Oshima RG. Defective trophoblast function in mice with a targeted mutation of Ets2. Genes Dev. 1998 May 01; 12(9):1315-26. PMID: 9573048; PMCID: PMC316781.
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    252. DiSandro MJ, Baskin LS, Li YW, Werb Z, Cunha GR. Development and regenerative ability of bladder in the transgenic epidermal growth factor receptor gene knockout mouse. J Urol. 1997 Sep; 158(3 Pt 2):1058-65. PMID: 9258142.
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    267. Huttenlocher A, Werb Z, Tremble P, Huhtala P, Rosenberg L, Damsky CH. Decorin regulates collagenase gene expression in fibroblasts adhering to vitronectin. Matrix Biol. 1996 Sep; 15(4):239-50. PMID: 8892224.
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    273. Logan SK, Garabedian MJ, Campbell CE, Werb Z. Synergistic transcriptional activation of the tissue inhibitor of metalloproteinases-1 promoter via functional interaction of AP-1 and Ets-1 transcription factors. J Biol Chem. 1996 Jan 12; 271(2):774-82. PMID: 8557686.
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    274. Wiesen JF, Werb Z. The role of stromelysin-1 in stromal-epithelial interactions and cancer. Enzyme Protein. 1996; 49(1-3):174-81. PMID: 8797005.
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    276. Behrendtsen O, Alexander CM, Werb Z. Cooperative interactions between extracellular matrix, integrins and parathyroid hormone-related peptide regulate parietal endoderm differentiation in mouse embryos. Development. 1995 Dec; 121(12):4137-48. PMID: 8575314.
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    277. Cross JC, Flannery ML, Blanar MA, Steingrimsson E, Jenkins NA, Copeland NG, Rutter WJ, Werb Z. Hxt encodes a basic helix-loop-helix transcription factor that regulates trophoblast cell development. Development. 1995 Aug; 121(8):2513-23. PMID: 7671815.
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    278. Miettinen PJ, Berger JE, Meneses J, Phung Y, Pedersen RA, Werb Z, Derynck R. Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor. Nature. 1995 Jul 27; 376(6538):337-41. PMID: 7630400.
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    279. Newman-Smith ED, Werb Z. Stem cell defects in parthenogenetic peri-implantation embryos. Development. 1995 Jul; 121(7):2069-77. PMID: 7635052.
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    280. Hansell EJ, Frisch SM, Tremble P, Murnane JP, Werb Z. Simian virus 40 transformation alters the actin cytoskeleton, expression of matrix metalloproteinases and inhibitors of metalloproteinases, and invasive behavior of normal and ataxia-telangiectasia human skin fibroblasts. Biochem Cell Biol. 1995 Jul-Aug; 73(7-8):373-89. PMID: 8703410.
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    281. Bissell MJ, Werb Z. Introduction: basic science aspects of breast cancer. Semin Cancer Biol. 1995 Jun; 6(3):117-8. PMID: 7495978.
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    282. Sympson CJ, Bissell MJ, Werb Z. Mammary gland tumor formation in transgenic mice overexpressing stromelysin-1. Semin Cancer Biol. 1995 Jun; 6(3):159-63. PMID: 7495984; PMCID: PMC3815639.
    283. Tremble P, Damsky CH, Werb Z. Components of the nuclear signaling cascade that regulate collagenase gene expression in response to integrin-derived signals. J Cell Biol. 1995 Jun; 129(6):1707-20. PMID: 7790365; PMCID: PMC2291183.
    284. Huhtala P, Humphries MJ, McCarthy JB, Tremble PM, Werb Z, Damsky CH. Cooperative signaling by alpha 5 beta 1 and alpha 4 beta 1 integrins regulates metalloproteinase gene expression in fibroblasts adhering to fibronectin. J Cell Biol. 1995 May; 129(3):867-79. PMID: 7537277; PMCID: PMC2120442.
    285. Boudreau N, Sympson CJ, Werb Z, Bissell MJ. Suppression of ICE and apoptosis in mammary epithelial cells by extracellular matrix. Science. 1995 Feb 10; 267(5199):891-3. PMID: 7531366; PMCID: PMC3004777.
    286. Cross JC, Werb Z, Fisher SJ. Implantation and the placenta: key pieces of the development puzzle. Science. 1994 Dec 02; 266(5190):1508-18. PMID: 7985020.
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    287. Tournier JM, Polette M, Hinnrasky J, Beck J, Werb Z, Basbaum C. Expression of gelatinase A, a mediator of extracellular matrix remodeling, by tracheal gland serous cells in culture and in vivo. J Biol Chem. 1994 Oct 14; 269(41):25454-64. PMID: 7929245.
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    288. Rappolee DA, Basilico C, Patel Y, Werb Z. Expression and function of FGF-4 in peri-implantation development in mouse embryos. Development. 1994 Aug; 120(8):2259-69. PMID: 7925026.
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    289. Sympson CJ, Talhouk RS, Alexander CM, Chin JR, Clift SM, Bissell MJ, Werb Z. Targeted expression of stromelysin-1 in mammary gland provides evidence for a role of proteinases in branching morphogenesis and the requirement for an intact basement membrane for tissue-specific gene expression. J Cell Biol. 1994 May; 125(3):681-93. PMID: 8175886; PMCID: PMC2119999.
    290. Tremble P, Chiquet-Ehrismann R, Werb Z. The extracellular matrix ligands fibronectin and tenascin collaborate in regulating collagenase gene expression in fibroblasts. Mol Biol Cell. 1994 Apr; 5(4):439-53. PMID: 7519905; PMCID: PMC301053.
    291. Shum L, Sakakura Y, Bringas P, Luo W, Snead ML, Mayo M, Crohin C, Millar S, Werb Z, Buckley S. EGF abrogation-induced fusilli-form dysmorphogenesis of Meckel's cartilage during embryonic mouse mandibular morphogenesis in vitro. Development. 1993 Jul; 118(3):903-17. PMID: 8076525.
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    292. Tremble PM, Lane TF, Sage EH, Werb Z. SPARC, a secreted protein associated with morphogenesis and tissue remodeling, induces expression of metalloproteinases in fibroblasts through a novel extracellular matrix-dependent pathway. J Cell Biol. 1993 Jun; 121(6):1433-44. PMID: 8509459; PMCID: PMC2119706.
    293. Sanchez-Lopez R, Alexander CM, Behrendtsen O, Breathnach R, Werb Z. Role of zinc-binding- and hemopexin domain-encoded sequences in the substrate specificity of collagenase and stromelysin-2 as revealed by chimeric proteins. J Biol Chem. 1993 Apr 05; 268(10):7238-47. PMID: 8463259.
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    294. Mac Auley A, Werb Z, Mirkes PE. Characterization of the unusually rapid cell cycles during rat gastrulation. Development. 1993 Mar; 117(3):873-83. PMID: 8325243.
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    295. Hu CC, Sakakura Y, Sasano Y, Shum L, Bringas P, Werb Z, Slavkin HC. Endogenous epidermal growth factor regulates the timing and pattern of embryonic mouse molar tooth morphogenesis. Int J Dev Biol. 1992 Dec; 36(4):505-16. PMID: 1295561.
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    296. Damsky CH, Werb Z. Signal transduction by integrin receptors for extracellular matrix: cooperative processing of extracellular information. Curr Opin Cell Biol. 1992 Oct; 4(5):772-81. PMID: 1329869.
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    297. Talhouk RS, Bissell MJ, Werb Z. Coordinated expression of extracellular matrix-degrading proteinases and their inhibitors regulates mammary epithelial function during involution. J Cell Biol. 1992 Sep; 118(5):1271-82. PMID: 1512297; PMCID: PMC2289583.
    298. Alexander CM, Werb Z. Targeted disruption of the tissue inhibitor of metalloproteinases gene increases the invasive behavior of primitive mesenchymal cells derived from embryonic stem cells in vitro. J Cell Biol. 1992 Aug; 118(3):727-39. PMID: 1639854; PMCID: PMC2289547.
    299. Rappolee DA, Sturm KS, Behrendtsen O, Schultz GA, Pedersen RA, Werb Z. Insulin-like growth factor II acts through an endogenous growth pathway regulated by imprinting in early mouse embryos. Genes Dev. 1992 Jun; 6(6):939-52. PMID: 1317321.
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    300. Behrendtsen O, Alexander CM, Werb Z. Metalloproteinases mediate extracellular matrix degradation by cells from mouse blastocyst outgrowths. Development. 1992 Feb; 114(2):447-56. PMID: 1317291.
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    301. Underwood JL, Rappolee DA, Flannery M, Werb Z. Tissue inhibitor of metalloproteinases is induced by nerve damage. Matrix Suppl. 1992; 1:330-1. PMID: 1480056.
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    302. Werb Z, Alexander CM, Adler RR. Expression and function of matrix metalloproteinases in development. Matrix Suppl. 1992; 1:337-43. PMID: 1480058.
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    303. Alexander CM, Behrendtsen O, Goldsmith J, Sturm K, Werb Z. A genetic approach to identifying the functions of metalloproteinases and their inhibitors in adult and developing mice. Matrix Suppl. 1992; 1:201-2. PMID: 1480024.
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    304. Damsky C, Tremble P, Werb Z. Signal transduction via the fibronectin receptor: do integrins regulate matrix remodeling? Matrix Suppl. 1992; 1:184-91. PMID: 1282660.
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    305. Warburton D, Seth R, Shum L, Horcher PG, Hall FL, Werb Z, Slavkin HC. Epigenetic role of epidermal growth factor expression and signalling in embryonic mouse lung morphogenesis. Dev Biol. 1992 Jan; 149(1):123-33. PMID: 1728582.
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    306. Tremble PM, Damsky CH, Werb Z. Fibronectin fragments, but not intact fibronectin, signalling through the fibronectin receptor induce metalloproteinase gene expression in fibroblasts. Matrix Suppl. 1992; 1:212-4. PMID: 1480029.
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    307. Nielsen LL, Werb Z, Pedersen RA. Induction of c-fos transcripts in early postimplantation mouse embryos by TGF-alpha, EGF, PDGF, and FGF. Mol Reprod Dev. 1991 Jul; 29(3):227-37. PMID: 1657054.
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    308. Talhouk RS, Chin JR, Unemori EN, Werb Z, Bissell MJ. Proteinases of the mammary gland: developmental regulation in vivo and vectorial secretion in culture. Development. 1991 Jun; 112(2):439-49. PMID: 1794314; PMCID: PMC2975574.
    309. Librach CL, Werb Z, Fitzgerald ML, Chiu K, Corwin NM, Esteves RA, Grobelny D, Galardy R, Damsky CH, Fisher SJ. 92-kD type IV collagenase mediates invasion of human cytotrophoblasts. J Cell Biol. 1991 Apr; 113(2):437-49. PMID: 1849141; PMCID: PMC2288933.
    310. Werb Z, Tremble P, Damsky CH. Regulation of extracellular matrix degradation by cell-extracellular matrix interactions. Cell Differ Dev. 1990 Dec 02; 32(3):299-306. PMID: 2151566.
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    311. Hahnel AC, Rappolee DA, Millan JL, Manes T, Ziomek CA, Theodosiou NG, Werb Z, Pedersen RA, Schultz GA. Two alkaline phosphatase genes are expressed during early development in the mouse embryo. Development. 1990 Oct; 110(2):555-64. PMID: 2133555.
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    312. Handagama P, Rappolee DA, Werb Z, Levin J, Bainton DF. Platelet alpha-granule fibrinogen, albumin, and immunoglobulin G are not synthesized by rat and mouse megakaryocytes. J Clin Invest. 1990 Oct; 86(4):1364-8. PMID: 2212018; PMCID: PMC296872.
    313. Crocker PR, Werb Z, Gordon S, Bainton DF. Ultrastructural localization of a macrophage-restricted sialic acid binding hemagglutinin, SER, in macrophage-hematopoietic cell clusters. Blood. 1990 Sep 15; 76(6):1131-8. PMID: 2205308.
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    314. Adler RR, Brenner CA, Werb Z. Expression of extracellular matrix-degrading metalloproteinases and metalloproteinase inhibitors is developmentally regulated during endoderm differentiation of embryonal carcinoma cells. Development. 1990 Sep; 110(1):211-20. PMID: 2081460.
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    315. Werb Z. Expression of EGF and TGF-alpha genes in early mammalian development. Mol Reprod Dev. 1990 Sep; 27(1):10-5. PMID: 2271180.
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    316. Unemori EN, Bouhana KS, Werb Z. Vectorial secretion of extracellular matrix proteins, matrix-degrading proteinases, and tissue inhibitor of metalloproteinases by endothelial cells. J Biol Chem. 1990 Jan 05; 265(1):445-51. PMID: 2152926.
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    317. Rappolee DA, Werb Z. mRNA phenotyping for studying gene expression in small numbers of cells: platelet-derived growth factor and other growth factors in wound-derived macrophages. Am J Respir Cell Mol Biol. 1990 Jan; 2(1):3-10. PMID: 2407272.
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    318. Alexander CM, Werb Z. Proteinases and extracellular matrix remodeling. Curr Opin Cell Biol. 1989 Oct; 1(5):974-82. PMID: 2697298.
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    319. Werb Z, Tremble PM, Behrendtsen O, Crowley E, Damsky CH. Signal transduction through the fibronectin receptor induces collagenase and stromelysin gene expression. J Cell Biol. 1989 Aug; 109(2):877-89. PMID: 2547805; PMCID: PMC2115739.
    320. Werb Z, Clark EJ. Phorbol diesters regulate expression of the membrane neutral metalloendopeptidase (EC in rabbit synovial fibroblasts and mammary epithelial cells. J Biol Chem. 1989 Jun 05; 264(16):9111-3. PMID: 2542298.
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    321. Brenner CA, Adler RR, Rappolee DA, Pedersen RA, Werb Z. Genes for extracellular-matrix-degrading metalloproteinases and their inhibitor, TIMP, are expressed during early mammalian development. Genes Dev. 1989 Jun; 3(6):848-59. PMID: 2744464.
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    322. Werb Z, Takemura R, Stenberg PE, Bainton DF. Directed exocytosis of secretory granules containing apolipoprotein E to the adherent surface and basal vacuoles of macrophages spreading on immobile immune complexes. Am J Pathol. 1989 Mar; 134(3):661-70. PMID: 2923186; PMCID: PMC1879533.
    323. Bainton DF, Takemura R, Stenberg PE, Werb Z. Rapid fragmentation and reorganization of Golgi membranes during frustrated phagocytosis of immobile immune complexes by macrophages. Am J Pathol. 1989 Jan; 134(1):15-26. PMID: 2913823; PMCID: PMC1879551.
    324. Unemori EN, Werb Z. Collagenase expression and endogenous activation in rabbit synovial fibroblasts stimulated by the calcium ionophore A23187. J Biol Chem. 1988 Nov 05; 263(31):16252-9. PMID: 2846541.
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    325. Rappolee DA, Brenner CA, Schultz R, Mark D, Werb Z. Developmental expression of PDGF, TGF-alpha, and TGF-beta genes in preimplantation mouse embryos. Science. 1988 Sep 30; 241(4874):1823-5. PMID: 3175624.
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    326. Rappolee DA, Werb Z. Secretory products of phagocytes. Curr Opin Immunol. 1988 Sep-Oct; 1(1):47-55. PMID: 3077299.
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    327. Rappolee DA, Mark D, Banda MJ, Werb Z. Wound macrophages express TGF-alpha and other growth factors in vivo: analysis by mRNA phenotyping. Science. 1988 Aug 05; 241(4866):708-12. PMID: 3041594.
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    328. Banda MJ, Herron GS, Murphy G, Werb Z, Dwyer KS. Proteinase induction by endothelial cells during wound repair. Prog Clin Biol Res. 1988; 266:117-30. PMID: 2837786.
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    329. Chan LM, Hatier C, Parry G, Werb Z, Bissell MJ. Collagen-fibronectin interactions in normal and Rous sarcoma virus-transformed avian tendon cells: possible mechanisms for increased extracellular matrix turnover after transformation. In Vitro Cell Dev Biol. 1987 Apr; 23(4):308-14. PMID: 3032890.
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    330. Unemori EN, Werb Z. Reorganization of polymerized actin: a possible trigger for induction of procollagenase in fibroblasts cultured in and on collagen gels. J Cell Biol. 1986 Sep; 103(3):1021-31. PMID: 3017994; PMCID: PMC2114314.
    331. Werb Z, Hembry RM, Murphy G, Aggeler J. Commitment to expression of the metalloendopeptidases, collagenase and stromelysin: relationship of inducing events to changes in cytoskeletal architecture. J Cell Biol. 1986 Mar; 102(3):697-702. PMID: 3005336; PMCID: PMC2114137.
    332. Takemura R, Stenberg PE, Bainton DF, Werb Z. Rapid redistribution of clathrin onto macrophage plasma membranes in response to Fc receptor-ligand interaction during frustrated phagocytosis. J Cell Biol. 1986 Jan; 102(1):55-69. PMID: 2867099; PMCID: PMC2114055.
    333. Werb Z, Chin JR, Takemura R, Oropeza RL, Bainton DF, Stenberg P, Taylor JM, Reardon C. The cell and molecular biology of apolipoprotein E synthesis by macrophages. Ciba Found Symp. 1986; 118:155-71. PMID: 3525037.
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    334. Chin JR, Murphy G, Werb Z. Stromelysin, a connective tissue-degrading metalloendopeptidase secreted by stimulated rabbit synovial fibroblasts in parallel with collagenase. Biosynthesis, isolation, characterization, and substrates. J Biol Chem. 1985 Oct 05; 260(22):12367-76. PMID: 2995374.
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    335. Sundsmo JS, Chin JR, Papin RA, Fair DS, Werb Z. Factor B, the complement alternative pathway serine proteinase, is a major constitutive protein synthesized and secreted by resident and elicited mouse macrophages. J Exp Med. 1985 Feb 01; 161(2):306-22. PMID: 3844438; PMCID: PMC2187560.
    336. Aggeler J, Frisch SM, Werb Z. Collagenase is a major gene product of induced rabbit synovial fibroblasts. J Cell Biol. 1984 May; 98(5):1656-61. PMID: 6327717; PMCID: PMC2113195.
    337. Takemura R, Werb Z. Modulation of apoprotein E secretion in response to receptor-mediated endocytosis in resident and inflammatory macrophages. J Exp Med. 1984 Jan 01; 159(1):167-78. PMID: 6198420; PMCID: PMC2187204.
    338. Takemura R, Werb Z. Regulation of elastase and plasminogen activator secretion in resident and inflammatory macrophages by receptors for the Fc domain of immunoglobulin G. J Exp Med. 1984 Jan 01; 159(1):152-66. PMID: 6229594; PMCID: PMC2187208.
    339. Werb Z, Chin JR. Onset of apoprotein E secretion during differentiation of mouse bone marrow-derived mononuclear phagocytes. J Cell Biol. 1983 Oct; 97(4):1113-8. PMID: 6604729; PMCID: PMC2112625.
    340. Werb Z, Chin JR. Apoprotein E is synthesized and secreted by resident and thioglycollate-elicited macrophages but not by pyran copolymer- or bacillus Calmette-Guerin-activated macrophages. J Exp Med. 1983 Oct 01; 158(4):1272-93. PMID: 6619735; PMCID: PMC2187376.
    341. Werb Z, Chin JR. Endotoxin suppresses expression of apoprotein E by mouse macrophages in vivo and in culture. A biochemical and genetic study. J Biol Chem. 1983 Sep 10; 258(17):10642-8. PMID: 6350291.
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    342. Glass RH, Aggeler J, Spindle A, Pedersen RA, Werb Z. Degradation of extracellular matrix by mouse trophoblast outgrowths: a model for implantation. J Cell Biol. 1983 Apr; 96(4):1108-16. PMID: 6339525; PMCID: PMC2112312.
    343. Enders GC, Werb Z, Friend DS. Lectin binding to guinea-pig sperm zipper particles. J Cell Sci. 1983 Mar; 60:303-29. PMID: 6874733.
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    344. Werb Z, Banda MJ, McKerrow JH, Sandhaus RA. Elastases and elastin degradation. J Invest Dermatol. 1982 Jul; 79 Suppl 1:154s-159s. PMID: 7045242.
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    345. Werb Z, Bainton DF, Jones PA. Degradation of connective tissue matrices by macrophages. III. Morphological and biochemical studies on extracellular, pericellular, and intracellular events in matrix proteolysis by macrophages in culture. J Exp Med. 1980 Dec 01; 152(6):1537-53. PMID: 7005386; PMCID: PMC2186033.
    346. Jones PA, Werb Z. Degradation of connective tissue matrices by macrophages. II. Influence of matrix composition on proteolysis of glycoproteins, elastin, and collagen by macrophages in culture. J Exp Med. 1980 Dec 01; 152(6):1527-36. PMID: 6450258; PMCID: PMC2186027.
    347. Werb Z, Banda MJ, Jones PA. Degradation of connective tissue matrices by macrophages. I. Proteolysis of elastin, glycoproteins, and collagen by proteinases isolated from macrophages. J Exp Med. 1980 Nov 01; 152(5):1340-57. PMID: 7000966; PMCID: PMC2186009.
    348. Werb Z, Foley R, Munck A. Interaction of glucocorticoids with macrophages. Identification of glucocorticoid receptors in monocytes and macrophages. J Exp Med. 1978 Jun 01; 147(6):1684-94. PMID: 681878; PMCID: PMC2184310.
    349. Werb Z. Biochemical actions of glucocorticoids on macrophages in culture. Specific inhibition of elastase, collagenase, and plasminogen activator secretion and effects on other metabolic functions. J Exp Med. 1978 Jun 01; 147(6):1695-1712. PMID: 210248; PMCID: PMC2184323.
    350. Werb Z, Gordon S. Secretion of a specific collagenase by stimulated macrophages. J Exp Med. 1975 Aug 01; 142(2):346-60. PMID: 167095; PMCID: PMC2189891.
    351. Werb Z, Gordon S. Elastase secretion by stimulated macrophages. Characterization and regulation. J Exp Med. 1975 Aug 01; 142(2):361-77. PMID: 167096; PMCID: PMC2189888.
    352. Werb Z, Cohn ZA. Cholesterol metabolism in the macrophage. I. The regulation of cholesterol exchange. J Exp Med. 1971 Dec 01; 134(6):1545-69. PMID: 5126640; PMCID: PMC2139099.
    353. Werb Z, Cohn ZA. Cholesterol metabolism in the macrophage. II. Alteration of subcellular exchangeable cholesterol compartments and exchange in other cell types. J Exp Med. 1971 Dec 01; 134(6):1570-90. PMID: 4942408; PMCID: PMC2139110.