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Avisek Majumder, PhD

Title(s)Postdoctoral Scholar, Medicine
SchoolSchool of Medicine
Phone415-353-7070
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    Collapse Biography 
    Collapse Education and Training
    University of Louisville, USAPhD2018Biochemistry and Molecular Genetics
    West Bengal University of Technology , IndiaMS2010Genetic Engineering

    Collapse Overview 
    Collapse Overview
    HER2 is a member of human epidermal growth receptors (EGFR/HER) family proteins. Overexpression of HER2 found in ~25% of breast tumors and is generally associated with poor patient survival. Although there are different small-molecule tyrosine kinase inhibitors (TKI), the anti-EGFR, and anti-HER2 antibodies therapies available which showed relative clinical success, tumors frequently develop resistance and patient relapse. Recent studies found that HER3 plays a key role in the pathophysiology of HER2-amplified breast cancers. Though HER3 is critical in early development (embryonic lethal in knockout mice) and expressed at very low levels in adult tissues such as skin and colon, yet it is commonly activated in many cancer types like breast, colorectal, and gastric cancer. My work is to understand how HER3 function in physiologic signaling and how this function is perturbed in cancer cells.

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. George AK, Homme RP, Majumder A, Tyagi SC, Singh M. Effect of MMP-9 gene knockout on retinal vascular form and function. Physiol Genomics. 2019 Dec 01; 51(12):613-622. PMID: 31709889.
      View in: PubMed
    2. George AK, Majumder A, Ice H, Homme RP, Eyob W, Tyagi SC, Singh M. Genes and genetics in hyperhomocysteinemia and the "1-carbon metabolism": implications for retinal structure and eye functions. Can J Physiol Pharmacol. 2020 Feb; 98(2):51-60. PMID: 31369712.
      View in: PubMed
    3. George AK, Homme RP, Majumder A, Laha A, Metreveli N, Sandhu HS, Tyagi SC, Singh M. Hydrogen sulfide intervention in cystathionine-ß-synthase mutant mouse helps restore ocular homeostasis. Int J Ophthalmol. 2019; 12(5):754-764. PMID: 31131233.
      View in: PubMed
    4. Singh M, George AK, Homme RP, Majumder A, Laha A, Sandhu HS, Tyagi SC. Expression Analysis of the Circular RNA Molecules in the Human Retinal Cells Treated with Homocysteine. Curr Eye Res. 2019 03; 44(3):287-293. PMID: 30369271.
      View in: PubMed
    5. George AK, Master K, Majumder A, Homme RP, Laha A, Sandhu HS, Tyagi SC, Singh M. Circular RNAs constitute an inherent gene regulatory axis in the mammalian eye and brain 1. Can J Physiol Pharmacol. 2019 Jun; 97(6):463-472. PMID: 30444648.
      View in: PubMed
    6. Majumder A, Singh M, George AK, Tyagi SC. Restoration of skeletal muscle homeostasis by hydrogen sulfide during hyperhomocysteinemia-mediated oxidative/ER stress condition 1. Can J Physiol Pharmacol. 2019 Jun; 97(6):441-456. PMID: 30422673.
      View in: PubMed
    7. Majumder A, Singh M, George AK, Homme RP, Laha A, Tyagi SC. Remote ischemic conditioning as a cytoprotective strategy in vasculopathies during hyperhomocysteinemia: An emerging research perspective. J Cell Biochem. 2019 01; 120(1):77-92. PMID: 30272816.
      View in: PubMed
    8. Homme RP, Singh M, Majumder A, George AK, Nair K, Sandhu HS, Tyagi N, Lominadze D, Tyagi SC. Remodeling of Retinal Architecture in Diabetic Retinopathy: Disruption of Ocular Physiology and Visual Functions by Inflammatory Gene Products and Pyroptosis. Front Physiol. 2018; 9:1268. PMID: 30233418.
      View in: PubMed
    9. Majumder A, Singh M, George AK, Behera J, Tyagi N, Tyagi SC. Hydrogen sulfide improves postischemic neoangiogenesis in the hind limb of cystathionine-ß-synthase mutant mice via PPAR-?/VEGF axis. Physiol Rep. 2018 09; 6(17):e13858. PMID: 30175474.
      View in: PubMed
    10. Majumder A, Singh M, Behera J, Theilen NT, George AK, Tyagi N, Metreveli N, Tyagi SC. Hydrogen sulfide alleviates hyperhomocysteinemia-mediated skeletal muscle atrophy via mitigation of oxidative and endoplasmic reticulum stress injury. Am J Physiol Cell Physiol. 2018 11 01; 315(5):C609-C622. PMID: 30110564.
      View in: PubMed
    11. Laha A, Majumder A, Singh M, Tyagi SC. Connecting homocysteine and obesity through pyroptosis, gut microbiome, epigenetics, peroxisome proliferator-activated receptor ?, and zinc finger protein 407. Can J Physiol Pharmacol. 2018 Oct; 96(10):971-976. PMID: 29890083.
      View in: PubMed
    12. Singh M, George AK, Homme RP, Majumder A, Laha A, Sandhu HS, Tyagi SC. Circular RNAs profiling in the cystathionine-ß-synthase mutant mouse reveals novel gene targets for hyperhomocysteinemia induced ocular disorders. Exp Eye Res. 2018 09; 174:80-92. PMID: 29803556.
      View in: PubMed
    13. George AK, Singh M, Homme RP, Majumder A, Sandhu HS, Tyagi SC. A hypothesis for treating inflammation and oxidative stress with hydrogen sulfide during age-related macular degeneration. Int J Ophthalmol. 2018; 11(5):881-887. PMID: 29862191.
      View in: PubMed
    14. Majumder A, Singh M, Tyagi SC. Post-menopausal breast cancer: from estrogen to androgen receptor. Oncotarget. 2017 Nov 24; 8(60):102739-102758. PMID: 29254284.
      View in: PubMed
    15. Majumder A, Behera J, Jeremic N, Tyagi SC. Hypermethylation: Causes and Consequences in Skeletal Muscle Myopathy. J Cell Biochem. 2017 08; 118(8):2108-2117. PMID: 27982479.
      View in: PubMed