Avisek Majumder, PhD

Title(s)Postdoctoral Scholar, Medicine
SchoolSchool of Medicine
Address1450 Third St
San Francisco CA 94158
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    University of Louisville, USAPhD2018Biochemistry and Molecular Genetics
    West Bengal University of Technology , IndiaMS2010Genetic Engineering

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    HER2 is a member of human epidermal growth receptors (EGFR/HER) family proteins. Overexpression of HER2 is found in ~25% of breast tumors and is generally associated with poor patient survival. Although there are different small-molecule tyrosine kinase inhibitors (TKIs) and anti-HER2 antibodies therapies that have been developed which showed relative clinical success, tumors frequently develop resistance and patient relapse. Recent studies found that the major cause of treatment failure in HER2 directed therapies is due to the drug-induced compensatory upregulation of HER3 (another member of HER family protein). Though HER3 is critical in early development (embryonic lethal in knockout mice) and expressed at very low levels in adult tissues such as skin and colon, yet it is commonly activated in many cancer types like breast, colorectal, and gastric cancer. My work is to understand how HER3 function in physiologic signaling and how this function is perturbed in cancer cells.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. The role of HER2 and HER3 in HER2-amplified cancers beyond breast cancers. Sci Rep. 2021 04 27; 11(1):9091. Majumder A, Sandhu M, Banerji D, Steri V, Olshen A, Moasser MM. PMID: 33907275; PMCID: PMC8079373.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    2. Effect of MMP-9 gene knockout on retinal vascular form and function. Physiol Genomics. 2019 12 01; 51(12):613-622. George AK, Homme RP, Majumder A, Tyagi SC, Singh M. PMID: 31709889; PMCID: PMC6962592.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    3. Genes and genetics in hyperhomocysteinemia and the "1-carbon metabolism": implications for retinal structure and eye functions. Can J Physiol Pharmacol. 2020 Feb; 98(2):51-60. George AK, Majumder A, Ice H, Homme RP, Eyob W, Tyagi SC, Singh M. PMID: 31369712.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    4. Hydrogen sulfide intervention in cystathionine-β-synthase mutant mouse helps restore ocular homeostasis. Int J Ophthalmol. 2019; 12(5):754-764. George AK, Homme RP, Majumder A, Laha A, Metreveli N, Sandhu HS, Tyagi SC, Singh M. PMID: 31131233; PMCID: PMC6520274.
      View in: PubMed   Mentions: 9  
    5. Expression Analysis of the Circular RNA Molecules in the Human Retinal Cells Treated with Homocysteine. Curr Eye Res. 2019 03; 44(3):287-293. Singh M, George AK, Homme RP, Majumder A, Laha A, Sandhu HS, Tyagi SC. PMID: 30369271; PMCID: PMC6709669.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    6. Circular RNAs constitute an inherent gene regulatory axis in the mammalian eye and brain 1. Can J Physiol Pharmacol. 2019 Jun; 97(6):463-472. George AK, Master K, Majumder A, Homme RP, Laha A, Sandhu HS, Tyagi SC, Singh M. PMID: 30444648.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    7. Restoration of skeletal muscle homeostasis by hydrogen sulfide during hyperhomocysteinemia-mediated oxidative/ER stress condition 1. Can J Physiol Pharmacol. 2019 Jun; 97(6):441-456. Majumder A, Singh M, George AK, Tyagi SC. PMID: 30422673; PMCID: PMC6719301.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    8. Remote ischemic conditioning as a cytoprotective strategy in vasculopathies during hyperhomocysteinemia: An emerging research perspective. J Cell Biochem. 2019 01; 120(1):77-92. Majumder A, Singh M, George AK, Homme RP, Laha A, Tyagi SC. PMID: 30272816.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    9. Remodeling of Retinal Architecture in Diabetic Retinopathy: Disruption of Ocular Physiology and Visual Functions by Inflammatory Gene Products and Pyroptosis. Front Physiol. 2018; 9:1268. Homme RP, Singh M, Majumder A, George AK, Nair K, Sandhu HS, Tyagi N, Lominadze D, Tyagi SC. PMID: 30233418; PMCID: PMC6134046.
      View in: PubMed   Mentions: 18  
    10. Hydrogen sulfide improves postischemic neoangiogenesis in the hind limb of cystathionine-β-synthase mutant mice via PPAR-γ/VEGF axis. Physiol Rep. 2018 09; 6(17):e13858. Majumder A, Singh M, George AK, Behera J, Tyagi N, Tyagi SC. PMID: 30175474; PMCID: PMC6119702.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    11. Hydrogen sulfide alleviates hyperhomocysteinemia-mediated skeletal muscle atrophy via mitigation of oxidative and endoplasmic reticulum stress injury. Am J Physiol Cell Physiol. 2018 11 01; 315(5):C609-C622. Majumder A, Singh M, Behera J, Theilen NT, George AK, Tyagi N, Metreveli N, Tyagi SC. PMID: 30110564; PMCID: PMC6293052.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimals
    12. Connecting homocysteine and obesity through pyroptosis, gut microbiome, epigenetics, peroxisome proliferator-activated receptor γ, and zinc finger protein 407. Can J Physiol Pharmacol. 2018 Oct; 96(10):971-976. Laha A, Majumder A, Singh M, Tyagi SC. PMID: 29890083.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    13. Circular RNAs profiling in the cystathionine-β-synthase mutant mouse reveals novel gene targets for hyperhomocysteinemia induced ocular disorders. Exp Eye Res. 2018 09; 174:80-92. Singh M, George AK, Homme RP, Majumder A, Laha A, Sandhu HS, Tyagi SC. PMID: 29803556.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    14. A hypothesis for treating inflammation and oxidative stress with hydrogen sulfide during age-related macular degeneration. Int J Ophthalmol. 2018; 11(5):881-887. George AK, Singh M, Homme RP, Majumder A, Sandhu HS, Tyagi SC. PMID: 29862191; PMCID: PMC5957044.
      View in: PubMed   Mentions: 13  
    15. Post-menopausal breast cancer: from estrogen to androgen receptor. Oncotarget. 2017 Nov 24; 8(60):102739-102758. Majumder A, Singh M, Tyagi SC. PMID: 29254284; PMCID: PMC5731994.
      View in: PubMed   Mentions: 10     Fields:    
    16. Hypermethylation: Causes and Consequences in Skeletal Muscle Myopathy. J Cell Biochem. 2017 08; 118(8):2108-2117. Majumder A, Behera J, Jeremic N, Tyagi SC. PMID: 27982479; PMCID: PMC6563903.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
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