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Donald Koblin, PhD, MD

TitleProfessor Emeritus
SchoolUCSF School of Medicine
DepartmentAnesthesia
Address550 16th Street
San Francisco CA 94158
Phone415-750-2069
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Koblin D. Urethane: help or hindrance? Anesth Analg. 2002 Feb; 94(2):241-2. PMID: 11812676.
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    2. Eger EI, Halsey MJ, Koblin D, Laster MJ, Ionescu P, Königsberger K, Fan R, Nguyen BV, Hudlicky T. The convulsant and anesthetic properties of cis-trans isomers of 1,2-dichlorohexafluorocyclobutane and 1,2-dichloroethylene. Anesth Analg. 2001 Oct; 93(4):922-7. PMID: 11574358.
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    3. Eger EI, Halsey MJ, Harris RA, Koblin D, Pohorille A, Sewell JC, Sonner JM, Trudell JR. Hypothesis: volatile anesthetics produce immobility by acting on two sites approximately five carbon atoms apart. Anesth Analg. 1999 Jun; 88(6):1395-400. PMID: 10357351.
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    4. Koblin D, Laster MJ, Ionescu P, Gong D, Eger EI, Halsey MJ, Hudlicky T. Polyhalogenated methyl ethyl ethers: solubilities and anesthetic properties. Anesth Analg. 1999 May; 88(5):1161-7. PMID: 10320188.
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    5. Eger EI, Koblin D, Sonner J, Gong D, Laster MJ, Ionescu P, Halsey MJ, Hudlicky T. Nonimmobilizers and transitional compounds may produce convulsions by two mechanisms. Anesth Analg. 1999 Apr; 88(4):884-92. PMID: 10195542.
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    6. Koblin D, Fang Z, Eger EI, Laster MJ, Gong D, Ionescu P, Halsey MJ, Trudell JR. Minimum alveolar concentrations of noble gases, nitrogen, and sulfur hexafluoride in rats: helium and neon as nonimmobilizers (nonanesthetics) Anesth Analg. 1998 Aug; 87(2):419-24. PMID: 9706943.
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    7. Trudell JR, Koblin D, Eger EI. A molecular description of how noble gases and nitrogen bind to a model site of anesthetic action. Anesth Analg. 1998 Aug; 87(2):411-8. PMID: 9706942.
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    8. Yost CS, Hampson AJ, Leonoudakis D, Koblin D, Bornheim LM, Gray AT. Oleamide potentiates benzodiazepine-sensitive gamma-aminobutyric acid receptor activity but does not alter minimum alveolar anesthetic concentration. Anesth Analg. 1998 Jun; 86(6):1294-300. PMID: 9620523.
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    9. Eger EI, Gong D, Koblin D, Bowland T, Ionescu P, Laster MJ, Weiskopf RB. The effect of anesthetic duration on kinetic and recovery characteristics of desflurane versus sevoflurane, and on the kinetic characteristics of compound A, in volunteers. Anesth Analg. 1998 Feb; 86(2):414-21. PMID: 9459259.
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    10. Eger EI, Gong D, Koblin D, Bowland T, Ionescu P, Laster MJ, Weiskopf RB. Dose-related biochemical markers of renal injury after sevoflurane versus desflurane anesthesia in volunteers. Anesth Analg. 1997 Nov; 85(5):1154-63. PMID: 9356118.
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    11. Fang Z, Laster MJ, Ionescu P, Koblin D, Sonner J, Eger EI, Halsey MJ. Effects of inhaled nonimmobilizer, proconvulsant compounds on desflurane minimum alveolar anesthetic concentration in rats. Anesth Analg. 1997 Nov; 85(5):1149-53. PMID: 9356117.
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    12. Griffiths R, Ionescu P, Fang Z, Koblin D, Eger EI. Enhanced choline acetyltransferase activity does not explain the action of inhaled convulsants. Br J Anaesth. 1997 Sep; 79(3):389-91. PMID: 9389863.
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    13. Eger EI, Koblin D, Laster MJ, Schurig V, Juza M, Ionescu P, Gong D. Minimum alveolar anesthetic concentration values for the enantiomers of isoflurane differ minimally. Anesth Analg. 1997 Jul; 85(1):188-92. PMID: 9212145.
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    14. Eger EI, Koblin D, Harris RA, Kendig JJ, Pohorille A, Halsey MJ, Trudell JR. Hypothesis: inhaled anesthetics produce immobility and amnesia by different mechanisms at different sites. Anesth Analg. 1997 Apr; 84(4):915-8. PMID: 9085981.
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    15. Fang Z, Laster MJ, Gong D, Ionescu P, Koblin D, Sonner J, Eger EI, Halsey MJ. Convulsant activity of nonanesthetic gas combinations. Anesth Analg. 1997 Mar; 84(3):634-40. PMID: 9052316.
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    16. Eger EI, Koblin D, Bowland T, Ionescu P, Laster MJ, Fang Z, Gong D, Sonner J, Weiskopf RB. Nephrotoxicity of sevoflurane versus desflurane anesthesia in volunteers. Anesth Analg. 1997 Jan; 84(1):160-8. PMID: 8989018.
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    17. Fang Z, Sonner J, Laster MJ, Ionescu P, Kandel L, Koblin D, Eger EI, Halsey MJ. Anesthetic and convulsant properties of aromatic compounds and cycloalkanes: implications for mechanisms of narcosis. Anesth Analg. 1996 Nov; 83(5):1097-104. PMID: 8895293.
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    18. Eger EI, Ionescu P, Koblin D, Weiskopf RB. Compound A: solubility in saline and olive oil; destruction by blood. Anesth Analg. 1996 Oct; 83(4):849-53. PMID: 8831333.
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    19. Eger EI, Koblin D. Binding of halothane to serum albumin: relevance to theories of narcosis. Anesthesiology. 1995 Dec; 83(6):1384-5. PMID: 8533948.
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    20. Eger EI, Koblin D. Unitary versus multiple mechanisms of anesthesia. Anesthesiology. 1995 Dec; 83(6):1368. PMID: 8533934.
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    21. Lin L, Koblin D, Wang HH. Effects of halothane on the nicotinic acetylcholine receptor from Torpedo californica. Biochem Pharmacol. 1995 Apr 18; 49(8):1085-9. PMID: 7748189.
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    22. Koblin D. Prolonged asystolic hyperkalemic cardiac arrest with no neurologic sequelae: the lazarus phenomenon arises again. Ann Emerg Med. 1995 Apr; 25(4):562-3. PMID: 7755795.
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    23. Koblin D. Homocystinuria and administration of nitrous oxide. J Clin Anesth. 1995 Mar; 7(2):176. PMID: 7661974.
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    24. Koblin D, Chortkoff BS, Laster MJ, Eger EI, Halsey MJ, Ionescu P. Polyhalogenated and perfluorinated compounds that disobey the Meyer-Overton hypothesis. Anesth Analg. 1994 Dec; 79(6):1043-8. PMID: 7978424.
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    25. Chortkoff BS, Laster MJ, Koblin D, Taheri S, Eger EI, Halsey MJ. Pharmacokinetics do not explain the absence of an anesthetic effect of perfluoropropane or perfluoropentane. Anesth Analg. 1994 Aug; 79(2):234-7. PMID: 7639356.
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    26. Liu J, Laster MJ, Koblin D, Eger EI, Halsey MJ, Taheri S, Chortkoff B. A cutoff in potency exists in the perfluoroalkanes. Anesth Analg. 1994 Aug; 79(2):238-44. PMID: 7639357.
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    27. Eger EI, Liu J, Koblin D, Laster MJ, Taheri S, Halsey MJ, Ionescu P, Chortkoff BS, Hudlicky T. Molecular properties of the "ideal" inhaled anesthetic: studies of fluorinated methanes, ethanes, propanes, and butanes. Anesth Analg. 1994 Aug; 79(2):245-51. PMID: 7639358.
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    28. Navarro R, Weiskopf RB, Moore MA, Lockhart S, Eger EI, Koblin D, Lu G, Wilson C. Humans anesthetized with sevoflurane or isoflurane have similar arrhythmic response to epinephrine. Anesthesiology. 1994 Mar; 80(3):545-9. PMID: 7511357.
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    29. Koblin D. The Lazarus phenomenon re-revisited. Anesthesiology. 1993 Dec; 79(6):1438-9. PMID: 8110280.
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    30. Taheri S, Laster MJ, Liu J, Eger EI, Halsey MJ, Koblin D. Anesthesia by n-alkanes not consistent with the Meyer-Overton hypothesis: determinations of the solubilities of alkanes in saline and various lipids. Anesth Analg. 1993 Jul; 77(1):7-11. PMID: 8317750.
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    31. Liu J, Laster MJ, Taheri S, Eger EI, Koblin D, Halsey MJ. Is there a cutoff in anesthetic potency for the normal alkanes? Anesth Analg. 1993 Jul; 77(1):12-8. PMID: 8317717.
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    32. Koblin D, Laster MJ, Liu J. Anaesthetic properties of dimethylthiourea. Br J Anaesth. 1993 Apr; 70(4):456-8. PMID: 8499210.
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    33. Koblin D. Characteristics and implications of desflurane metabolism and toxicity. Anesth Analg. 1992 Oct; 75(4 Suppl):S10-6. PMID: 1524235.
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    34. Everman BW, Koblin D. Aging, chronic administration of ethanol, and acute exposure to nitrous oxide: effects on vitamin B12 and folate status in rats. Mech Ageing Dev. 1992 Mar 01; 62(3):229-43. PMID: 1583909.
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    35. Sutton TS, Koblin D, Gruenke LD, Weiskopf RB, Rampil IJ, Waskell L, Eger EI. Fluoride metabolites after prolonged exposure of volunteers and patients to desflurane. Anesth Analg. 1991 Aug; 73(2):180-5. PMID: 1854033.
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    36. Koblin D, Everman BW. Vitamin B12 and folate status in rats after chronic administration of ethanol and acute exposure to nitrous oxide. Alcohol Clin Exp Res. 1991 Jun; 15(3):543-8. PMID: 1877742.
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    37. Taheri S, Halsey MJ, Liu J, Eger EI, Koblin D, Laster MJ. What solvent best represents the site of action of inhaled anesthetics in humans, rats, and dogs? Anesth Analg. 1991 May; 72(5):627-34. PMID: 2018220.
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    38. Lin L, Koblin D, Wang HH. Saturable binding of anesthetics to nicotinic acetylcholine receptors. A possible mechanism of anesthetic action. Ann N Y Acad Sci. 1991; 625:628-44. PMID: 1647740.
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    39. Waldman FM, Koblin D, Lampe GH, Wauk LZ, Eger EI. Hematologic effects of nitrous oxide in surgical patients. Anesth Analg. 1990 Dec; 71(6):618-24. PMID: 2240634.
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    40. Koblin D, Tomerson BW, Waldman FM, Lampe GH, Wauk LZ, Eger EI. Effect of nitrous oxide on folate and vitamin B12 metabolism in patients. Anesth Analg. 1990 Dec; 71(6):610-7. PMID: 2240633.
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    41. Koblin D, Tomerson BW, Waldman FM. Disruption of folate and vitamin B12 metabolism in aged rats following exposure to nitrous oxide. Anesthesiology. 1990 Sep; 73(3):506-12. PMID: 2393136.
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    42. Jones RM, Koblin D, Cashman JN, Eger EI, Johnson BH, Damask MC. Biotransformation and hepato-renal function in volunteers after exposure to desflurane (I-653). Br J Anaesth. 1990 Apr; 64(4):482-7. PMID: 2334623.
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    43. Koblin D, Tomerson BW. Dimethylthiourea, a hydroxyl radical scavenger, impedes the inactivation of methionine synthase by nitrous oxide in mice. Br J Anaesth. 1990 Feb; 64(2):214-23. PMID: 2107864.
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    44. Koblin D. Nitrous oxide: a cause of cancer or chemotherapeutic adjuvant? Semin Surg Oncol. 1990; 6(3):141-7. PMID: 2189194.
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    45. Koblin D. Nitrous oxide interferes with the aminopyrine breath test. Hepatology. 1989 Oct; 10(4):526-7. PMID: 2506122.
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    46. Gauntlett IS, Koblin D, Fahey MR, Konopka K, Gruenke LD, Waskell L, Eger EI. Metabolism of isoflurane in patients receiving isoniazid. Anesth Analg. 1989 Aug; 69(2):245-9. PMID: 2764294.
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    47. Targ AG, Yasuda N, Eger EI, Huang G, Vernice GG, Terrell RC, Koblin D. Halogenation and anesthetic potency. Anesth Analg. 1989 May; 68(5):599-602. PMID: 2719290.
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    48. Koblin D, Tomerson BW. Methionine synthase activities in mice following acute exposures to ethanol and nitrous oxide. Biochem Pharmacol. 1989 Apr 15; 38(8):1353-8. PMID: 2706023.
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    49. Koblin D, Weiskopf RB, Holmes MA, Konopka K, Rampil IJ, Eger EI, Waskell L. Metabolism of I-653 and isoflurane in swine. Anesth Analg. 1989 Feb; 68(2):147-9. PMID: 2913848.
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    50. Roizen MF, Koblin D, Johnson BH, Eger EI, Bainton CR, Lurz FW. Mechanism of age-related and nitrous oxide-associated anesthetic sensitivity: the role of brain catecholamines. Anesthesiology. 1988 Nov; 69(5):716-20. PMID: 3189918.
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    51. Koblin D, Eger EI, Johnson BH, Konopka K, Waskell L. I-653 resists degradation in rats. Anesth Analg. 1988 Jun; 67(6):534-8. PMID: 3377207.
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    52. Gutstein HB, Koblin D. Craniotomy for tumor in a patient with a bronchopleural fistula: anesthetic considerations. Anesthesiology. 1987 Nov; 67(5):804-6. PMID: 3674484.
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    53. Koblin D, Romanoff ME, Martin DE, Hensley FA, Larach DR, Stauffer RA, Luck JC. Anesthetic management of the parturient receiving amiodarone. Anesthesiology. 1987 Apr; 66(4):551-3. PMID: 3565823.
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    54. Koblin D, Biebuyck JF. Is nitrous oxide a dangerous anesthetic for vitamin B12-deficient subjects? JAMA. 1986 Aug 08; 256(6):716. PMID: 3723770.
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    55. Koblin D. Cortisol following etomidate administration: should we give it the time of day? Anesthesiology. 1985 Jun; 62(6):843-4. PMID: 4003824.
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    56. Koblin D, Lurz FW, O'Connor B, Nelson NT, Eger EI, Bainton CR. Potencies of barbiturates in mice selectively bred for resistance or susceptibility to nitrous oxide anesthesia. Anesth Analg. 1984 Jan; 63(1):35-9. PMID: 6691562.
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    57. Koblin D, Lurz FW, Eger EI. Age-dependent alterations in nitrous oxide requirement of mice. Anesthesiology. 1983 May; 58(5):428-31. PMID: 6837994.
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    58. Waskell L, Koblin D, Canova-Davis E. The lipid composition of human liver microsomes. Lipids. 1982 Apr; 17(4):317-20. PMID: 7078361.
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    59. Koblin D, Waskell L, Watson JE, Stokstad EL, Eger EI. Nitrous oxide inactivates methionine synthetase in human liver. Anesth Analg. 1982 Feb; 61(2):75-8. PMID: 7198880.
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    60. Koblin D, O'Connor B, Deady JE, Eger EI. Potencies of convulsant drugs in mice selectively bred for resistance and susceptibility to nitrous oxide anesthesia. Anesthesiology. 1982 Jan; 56(1):25-8. PMID: 7053665.
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    61. Koblin D, Deady JE, Eger EI. Potencies of inhaled anesthetics and alcohol in mice selectively bred for resistance and susceptibility to nitrous oxide anesthesia. Anesthesiology. 1982 Jan; 56(1):18-24. PMID: 7053664.
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    62. Koblin D, Wang HH. Chronic exposure to inhaled anesthetics increases cholesterol content in Acholeplasma laidlawii. Biochim Biophys Acta. 1981 Dec 21; 649(3):717-25. PMID: 6274406.
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    63. Koblin D, Eger EI. Cross-mating of mice selectively bred for resistance or susceptibility to nitrous oxide anesthesia: potencies of nitrous oxide in offspring. Anesth Analg. 1981 Sep; 60(9):646-8. PMID: 7196708.
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    64. Koblin D, Eger EI, Johnson BH, Collins P, Terrell RC, Speers L. Are convulsant gases also anesthetics? Anesth Analg. 1981 Jul; 60(7):464-70. PMID: 7195661.
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    65. Deady JE, Koblin D, Eger EI, Heavner JE, D'Aoust B. Anesthetic potencies and the unitary theory of narcosis. Anesth Analg. 1981 Jun; 60(6):380-4. PMID: 7195159.
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    66. Koblin D, Deady JE. Sensitivity to alcohol in mice with an altered brain fatty acid composition. Life Sci. 1981 Apr 27; 28(17):1889-96. PMID: 7253796.
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    67. Eger EI, Koblin D, Collins PA. Dioxychlorane: a challenge to the correlation of anesthetic potency and lipid solubility. Anesth Analg. 1981 Apr; 60(4):201-3. PMID: 7193998.
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    68. Koblin D, Watson JE, Deady JE, Stokstad EL, Eger EI. Inactivation of methionine synthetase by nitrous oxide in mice. Anesthesiology. 1981 Apr; 54(4):318-24. PMID: 7212332.
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    69. Koblin D, Eger EI, Johnson BH, Collins P, Harper MH, Terrell RC, Speers L. Minimum alveolar concentrations and oil/gas partition coefficients of four anesthetic isomers. Anesthesiology. 1981 Apr; 54(4):314-7. PMID: 6782912.
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    70. Koblin D, Deady JE, Nelson NT, Eger EI, Bainton CR. Mice tolerant to nitrous oxide are not tolerant to barbiturates. Anesth Analg. 1981 Mar; 60(3):138-41. PMID: 7193990.
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    71. Koblin D. Anesthetic requirement in the quaking mouse. Anesthesiology. 1981 Jan; 54(1):17-22. PMID: 7457978.
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    72. Koblin D, Deady JE. Anaesthetic requirement in mice selectively bred for differences in ethanol sensitivity. Br J Anaesth. 1981 Jan; 53(1):5-10. PMID: 7459186.
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    73. Koblin D, Little HJ, Green AR, Daniels S, Smith EB, Paton WD. Brain monoamines and the high pressure neurological syndrome. Neuropharmacology. 1980 Nov; 19(11):1031-8. PMID: 6449674.
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    74. Koblin D, Deady JE, Dong DE, Eger EI. Mice tolerant to nitrous oxide are also tolerant to alcohol. J Pharmacol Exp Ther. 1980 May; 213(2):309-12. PMID: 7365690.
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    75. Koblin D, Dong DE, Deady JE, Eger EI. Selective breeding alters murine resistance to nitrous oxide without alteration in synaptic membrane lipid composition. Anesthesiology. 1980 May; 52(5):401-7. PMID: 7377573.
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    76. Koblin D, Dong DE, Deady JE, Eger EI. Alteration of synaptic membrane fatty acid composition and anesthetic requirement. J Pharmacol Exp Ther. 1980 Mar; 212(3):546-52. PMID: 6244388.
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    77. Harper MH, Winter PM, Johnson BH, Koblin D, Eger EI. Withdrawal convulsions in mice following nitrous oxide. Anesth Analg. 1980 Jan; 59(1):19-21. PMID: 7188661.
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    78. Koblin D, Eger EI. Current concepts: theories of narcosis. N Engl J Med. 1979 Nov 29; 301(22):1222-4. PMID: 228191.
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    79. Koblin D, Dong DE, Eger EI. Tolerance of mice to nitrous oxide. J Pharmacol Exp Ther. 1979 Nov; 211(2):317-25. PMID: 228023.
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    80. Koblin D, Lester HA. Voltage-dependent and voltage-independent blockade of acetylcholine receptors by local anesthetics in Electrophorus electroplaques. Mol Pharmacol. 1979 May; 15(3):559-80. PMID: 492146.
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    81. Eger EI, Smith RA, Koblin D. The concentration effect can be mimicked by a decrease in blood solubility. Anesthesiology. 1978 Oct; 49(4):282-4. PMID: 697085.
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    82. Lester HA, Koblin D, Sheridan RE. Role of voltage-sensitive receptors in nicotinic transmission. Biophys J. 1978 Mar; 21(3):181-94. PMID: 630039; PMCID: PMC1473691.
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    83. Koblin D, Wang HH. The effect of chemical modifiers on the interaction of a spin-labeled local anesthetic with human erythrocyte membranes. Biochem Pharmacol. 1976 Jun 15; 25(12):1405-13. PMID: 7266.
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    84. Koblin D, Pace WD, Wang HH. The penetration of local anesthetics into the red blood cell membrane as studied by fluorescence quenching. Arch Biochem Biophys. 1975 Nov; 171(1):176-82. PMID: 1190792.
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    85. Koblin D, Kaufmann SA, Wang HH. Quenching of 1-anilinonaphthalene-8-sulfonate fluorescence by a spin-labeled local anesthetic: a membrane phenomenon. Biochem Biophys Res Commun. 1973 Aug 21; 53(4):1077-83. PMID: 4748807.
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