Jan Christoph, PhD, MSc

Title(s)Assistant Professor, Cardiovascular Research Inst
SchoolSchool of Medicine
AddressSan Francisco CA 94158
ORCID ORCID Icon0000-0003-3594-4717 Additional info
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    National Institutes of Health2022  - 20271DP2HL168071-01

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    Jan Christoph studies the heart from a complex and dynamical systems perspective. He is interested in arrhythmia mechanisms and the coupling between electrophysiology and tissue mechanics, as well as electromechanical feedback. He uses computational methods, artificial intelligence and high-resolution imaging to study the heart.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Utilization of Broad Consent as an Effective Instrument for Study Recruitment. Stud Health Technol Inform. 2025 Sep 03; 331:73-80. Apfelbacher T, Koçman SE, Negash S, Manuilova I, Mang JM, Papon H, Mikolajczyk R, Prokosch HU, Christoph J. PMID: 40899529.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    2. AAV9-mediated KCNH2 suppression-replacement gene therapy in a transgenic rabbit model of type 1 short QT syndrome. Eur Heart J. 2025 Aug 30. Nimani S, Bains S, Alerni N, Ördög B, Horváth A, Matas L, Louradour J, Giammarino L, Tester DJ, Beslac O, Lopez R, Meier S, Egle M, Christoforou N, Barbieri M, Vashanthakumar V, Perez-Feliz S, Parodi C, Garcia Casalta LG, Kim CSJ, Zhou W, Ye D, Jurgensen J, Barry MA, Bego M, Keyes L, Owens J, Pinkstaff J, Christoph J, Zehender M, Brunner M, Heijman J, Casoni D, Praz F, Haeberlin A, Brooks G, Ackerman MJ, Odening KE. PMID: 40884219.
      View in: PubMed   Mentions:    Fields:    
    3. Uncovering the Understanding of the Concept of Patient Similarity in Cancer Research and Treatment: Scoping Review. J Med Internet Res. 2025 Aug 18; 27:e71906. Manuilova I, Bossenz J, Weise AB, Boehm D, Döbel M, Werle SD, Ustjanzew A, Reimer N, Strantz C, Unberath P, Metzger P, Pauli T, Schulze S, Hiemer S, Oguztürk I, Kamkar L, Kestler HA, Busch H, Brors B, Christoph J. PMID: 40824687; PMCID: PMC12402742.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    4. Building a Knowledge Base for Variant Annotation Using Therapy Recommendations in cBioPortal. Stud Health Technol Inform. 2025 May 15; 327:98-102. Boehm D, Reimer N, Christoph J, Scheiter A, Unberath P. PMID: 40380393.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    5. Prototypical Visualization of Patient Similarities in cBioPortal to Enhance Decision-Making in Molecular Tumor Boards. Stud Health Technol Inform. 2025 May 15; 327:487-491. Bossenz J, Manuilova I, Weise AB, Schulze S, Hiemer S, Eszlinger M, Boerries M, Busch H, Boehm D, Unberath P, Reimer N, Strantz C, Christoph J. PMID: 40380495.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    6. Empowering personalized oncology: evolution of digital support and visualization tools for molecular tumor boards. BMC Med Inform Decis Mak. 2025 Jan 16; 25(1):29. Strantz C, Böhm D, Ganslandt T, Börries M, Metzger P, Pauli T, Blaumeiser A, Scheiter A, Jung IC, Christoph J, Manuilova I, Strauch K, Ustjanzew A, Reimer N, Busch H, Unberath P. PMID: 39819625; PMCID: PMC11736948.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    7. Identifications of Similarity Metrics for Patients With Cancer: Protocol for a Scoping Review. JMIR Res Protoc. 2024 Sep 04; 13:e58705. Manuilova I, Bossenz J, Weise AB, Boehm D, Strantz C, Unberath P, Reimer N, Metzger P, Pauli T, Werle SD, Schulze S, Hiemer S, Ustjanzew A, Kestler HA, Busch H, Brors B, Christoph J. PMID: 39230952; PMCID: PMC11411229.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    8. Dreaming of electrical waves: Generative modeling of cardiac excitation waves using diffusion models. APL Mach Learn. 2024 Sep 01; 2(3):036113. Baranwal T, Lebert J, Christoph J. PMID: 39364376; PMCID: PMC11446137.
      View in: PubMed   Mentions: 1  
    9. Dreaming of Electrical Waves: Generative Modeling of Cardiac Excitation Waves using Diffusion Models. ArXiv. 2024 Jun 03. Baranwal T, Lebert J, Christoph J. PMID: 38883235; PMCID: PMC11177957.
      View in: PubMed   Mentions:
    10. Data Visualization Support for Tumor Boards and Clinical Oncology: Protocol for a Scoping Review. JMIR Res Protoc. 2024 Mar 05; 13:e53627. Boehm D, Strantz C, Christoph J, Busch H, Ganslandt T, Unberath P. PMID: 38441925; PMCID: PMC10951826.
      View in: PubMed   Mentions: 2     Fields:    
    11. Extending cBioPortal for Therapy Recommendation Documentation in Molecular Tumor Boards: Development and Usability Study. JMIR Med Inform. 2023 Dec 11; 11:e50017. Renner C, Reimer N, Christoph J, Busch H, Metzger P, Boerries M, Ustjanzew A, Boehm D, Unberath P. PMID: 38079196; PMCID: PMC10750236.
      View in: PubMed   Mentions: 5     Fields:    
    12. Paralysis by analysis: Overcoming cardiac contraction with computer vision. Proc Natl Acad Sci U S A. 2023 10 17; 120(42):e2314448120. Christoph J, Ripplinger CM. PMID: 37792520; PMCID: PMC10589680.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    13. MIRACUM-Pipe: An Adaptable Pipeline for Next-Generation Sequencing Analysis, Reporting, and Visualization for Clinical Decision Making. Cancers (Basel). 2023 Jul 01; 15(13). Metzger P, Hess ME, Blaumeiser A, Pauli T, Schipperges V, Mertes R, Christoph J, Unberath P, Reimer N, Scheible R, Illert AL, Busch H, Andrieux G, Boerries M. PMID: 37444566; PMCID: PMC10340358.
      View in: PubMed   Mentions: 10  
    14. Optical mapping of contracting hearts. J Physiol. 2023 04; 601(8):1353-1370. Kappadan V, Sohi A, Parlitz U, Luther S, Uzelac I, Fenton F, Peters NS, Christoph J, Ng FS. PMID: 36866700; PMCID: PMC10952556.
      View in: PubMed   Mentions: 4     Fields:    
    15. Repolarization indicates electrical instability in ventricular arrhythmia originating from papillary muscle. Europace. 2023 02 16; 25(2):688-697. Münkler P, Klatt N, Scherschel K, Kuklik P, Jungen C, Cavus E, Eickholt C, Christoph J, Lemoine MD, Christ T, Willems S, Riedel R, Kirchhof P, Meyer C. PMID: 35989424; PMCID: PMC9935011.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    16. Reconstruction of three-dimensional scroll waves in excitable media from two-dimensional observations using deep neural networks. Phys Rev E. 2023 Jan; 107(1-1):014221. Lebert J, Mittal M, Christoph J. PMID: 36797900; PMCID: PMC11493429.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    17. N-glycosylation Regulates Intrinsic IFN-γ Resistance in Colorectal Cancer: Implications for Immunotherapy. Gastroenterology. 2023 03; 164(3):392-406.e5. Krug J, Rodrian G, Petter K, Yang H, Khoziainova S, Guo W, Bénard A, Merkel S, Gellert S, Maschauer S, Spermann M, Waldner M, Bailey P, Pilarsky C, Liebl A, Tripal P, Christoph J, Naschberger E, Croner R, Schellerer VS, Becker C, Hartmann A, Tüting T, Prante O, Grützmann R, Grivennikov SI, Stürzl M, Britzen-Laurent N. PMID: 36402190; PMCID: PMC10009756.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    18. Real-Time Optical Mapping of Contracting Cardiac Tissues With GPU-Accelerated Numerical Motion Tracking. Front Cardiovasc Med. 2022; 9:787627. Lebert J, Ravi N, Kensah G, Christoph J. PMID: 35686036; PMCID: PMC9172765.
      View in: PubMed   Mentions: 8  
    19. Searching of Clinical Trials Made Easier in cBioPortal Using Patients' Genetic and Clinical Profiles. Appl Clin Inform. 2022 03; 13(2):363-369. Unberath P, Mahlmeister L, Reimer N, Busch H, Boerries M, Christoph J. PMID: 35354211; PMCID: PMC8967483.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    20. cbpManager: a web application to streamline the integration of clinical and genomic data in cBioPortal to support the Molecular Tumor Board. BMC Med Inform Decis Mak. 2021 12 20; 21(1):358. Ustjanzew A, Desuki A, Ritzel C, Dolezilek AC, Wagner DC, Christoph J, Unberath P, Kindler T, Faber J, Marini F, Panholzer T, Paret C. PMID: 34930224; PMCID: PMC8686377.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    21. Rotor Localization and Phase Mapping of Cardiac Excitation Waves Using Deep Neural Networks. Front Physiol. 2021; 12:782176. Lebert J, Ravi N, Fenton FH, Christoph J. PMID: 34975536; PMCID: PMC8718715.
      View in: PubMed   Mentions: 9  
    22. Challenges and Experiences Extending the cBioPortal for Cancer Genomics to a Molecular Tumor Board Platform. Stud Health Technol Inform. 2021 Nov 18; 287:139-143. Reimer N, Unberath P, Busch H, Börries M, Metzger P, Ustjanzew A, Renner C, Prokosch HU, Christoph J. PMID: 34795098.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    23. Direct optogenetic stimulation of smooth muscle cells to control gastric contractility. Theranostics. 2021; 11(11):5569-5584. Vogt M, Schulz B, Wagdi A, Lebert J, van Belle GJ, Christoph J, Bruegmann T, Patejdl R. PMID: 33859764; PMCID: PMC8039938.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    24. Inverse mechano-electrical reconstruction of cardiac excitation wave patterns from mechanical deformation using deep learning. Chaos. 2020 Dec; 30(12):123134. Christoph J, Lebert J. PMID: 33380038.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    25. High-Resolution Optical Measurement of Cardiac Restitution, Contraction, and Fibrillation Dynamics in Beating vs. Blebbistatin-Uncoupled Isolated Rabbit Hearts. Front Physiol. 2020; 11:464. Kappadan V, Telele S, Uzelac I, Fenton F, Parlitz U, Luther S, Christoph J. PMID: 32528304; PMCID: PMC7264405.
      View in: PubMed   Mentions: 39  
    26. In silico signaling modeling to understand cancer pathways and treatment responses. Brief Bioinform. 2020 05 21; 21(3):1115-1117. Kunz M, Jeromin J, Fuchs M, Christoph J, Veronesi G, Flentje M, Nietzer S, Dandekar G, Dandekar T. PMID: 31117120.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    27. Requirements Analysis and Specification for a Molecular Tumor Board Platform Based on cBioPortal. Diagnostics (Basel). 2020 Feb 10; 10(2). Buechner P, Hinderer M, Unberath P, Metzger P, Boeker M, Acker T, Haller F, Mack E, Nowak D, Paret C, Schanze D, von Bubnoff N, Wagner S, Busch H, Boerries M, Christoph J. PMID: 32050609; PMCID: PMC7167859.
      View in: PubMed   Mentions: 21  
    28. Synchronization-based reconstruction of electromechanical wave dynamics in elastic excitable media. Chaos. 2019 Sep; 29(9):093117. Lebert J, Christoph J. PMID: 31575136.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    29. β6 -integrin serves as a novel serum tumor marker for colorectal carcinoma. Int J Cancer. 2019 08 01; 145(3):678-685. Bengs S, Becker E, Busenhart P, Spalinger MR, Raselli T, Kasper S, Lang S, Atrott K, Mamie C, Vavricka SR, von Boehmer L, Knuth A, Tuomisto A, Mäkinen MJ, Hruz P, Turina M, Rickenbacher A, Petrowsky H, Weber A, Frei P, Halama M, Jenkins G, Sheppard D, Croner RS, Christoph J, Britzen-Laurent N, Naschberger E, Schellerer V, Stürzl M, Fried M, Rogler G, Scharl M. PMID: 30653264.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    30. Marker-Free Tracking for Motion Artifact Compensation and Deformation Measurements in Optical Mapping Videos of Contracting Hearts. Front Physiol. 2018; 9:1483. Christoph J, Luther S. PMID: 30450053; PMCID: PMC6224482.
      View in: PubMed   Mentions: 20  
    31. Electromechanical vortex filaments during cardiac fibrillation. Nature. 2018 03 29; 555(7698):667-672. Christoph J, Chebbok M, Richter C, Schröder-Schetelig J, Bittihn P, Stein S, Uzelac I, Fenton FH, Hasenfuß G, Gilmour RF, Luther S. PMID: 29466325.
      View in: PubMed   Mentions: 73     Fields:    Translation:Animals
    32. Electromechanical optical mapping. Prog Biophys Mol Biol. 2017 11; 130(Pt B):150-169. Christoph J, Schröder-Schetelig J, Luther S. PMID: 28947080.
      View in: PubMed   Mentions: 16     Fields:    Translation:Animals
    33. Features of Chaotic Transients in Excitable Media Governed by Spiral and Scroll Waves. Phys Rev Lett. 2017 Aug 04; 119(5):054101. Lilienkamp T, Christoph J, Parlitz U. PMID: 28949756.
      View in: PubMed   Mentions: 10     Fields:    
    34. Optogenetic Light Crafting Tools for the Control of Cardiac Arrhythmias. Methods Mol Biol. 2016; 1408:293-302. Richter C, Christoph J, Lehnart SE, Luther S. PMID: 26965131.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
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