John Ambrose, MD, FACC

Title(s)Professor, Cardiology - Fresno
SchoolSchool of Medicine
AddressLocation Required, #Suite 40
Phone559-459-3872
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    John Ambrose, MD
    Professor

    Dr. John Ambrose is an internationally renowned expert in coronary artery disease and is one of the great pioneers in acute coronary syndromes. He has published extensively and his work has laid the foundation for the current theories on unstable angina, myocardial infarction and the vulnerable plaque, among others. Before coming to Fresno, Dr. Ambrose was the Director of the Cardiovascular Center at Saint Vincent Catholic Medical Centers in Manhattan. Before that, he was the Director of Cardiac Catheterization at Mount Sinai Medical Center in New York. He has been included in every edition of “Best Doctors in America.” Dr. Ambrose sang professionally in New York and continues to sing with his wife with the Fresno Grand Opera.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Time to Tweak the Definition of Type 2 Myocardial Infarction. Am J Cardiol. 2024 Mar 23. Ambrose JA, Kiel R, AlBayati A. PMID: 38527579.
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    2. Artificial Intelligence and the Doctor-Patient Relationship. Am J Med. 2024 Jan 27. Kingsford PA, Ambrose JA. PMID: 38281657.
      View in: PubMed   Mentions:    Fields:    
    3. Identifying and Treating Vulnerable Atherosclerotic Plaques. Am J Cardiol. 2023 10 15; 205:214-222. Ambrose JA, Sharma AV. PMID: 37611413.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    4. In Search of Coronary Thrombosis as the Cause of Myocardial Infarction: Unraveling a 20th-Century Mystery. Am J Med. 2022 05; 135(5):560-565. Ambrose JA, McEnroe DJ. PMID: 35081384.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    5. New Precordial T Wave Inversions in Hospitalized Patients. Am J Med. 2022 04; 135(4):517-523. Thinda N, Ambrose JA, Bhullar A, Huang S, Asadourian M, Sadhale A, Chua RA, Wessel R. PMID: 34813739.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    6. The Reply. Am J Med. 2021 03; 134(3):e227. Ambrose JA. PMID: 33637185.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    7. The Look Inside: Is it Clinically Relevant? JACC Cardiovasc Imaging. 2021 06; 14(6):1246-1248. Ambrose JA, Poosti K. PMID: 33221244.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    8. Reducing Tobacco-Related Morbidity and Mortality-A Call to Action. JAMA Cardiol. 2020 08 01; 5(8):860-862. Ambrose JA, Najafi A, Barua R. PMID: 32432653.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    9. Reducing Tobacco-Related Disability in Chronic Smokers. Am J Med. 2020 08; 133(8):908-915. Ambrose JA, Najafi A, Jain V, Muller JE, Ranka S, Barua RS. PMID: 32325048.
      View in: PubMed   Mentions:    Fields:    Translation:HumansPHPublic Health
    10. Anatomic or functional testing in stable patients with suspected CAD: contemporary role of cardiac CT in the ISCHEMIA trial era. Int J Cardiovasc Imaging. 2020 Jul; 36(7):1351-1362. Rodriguez-Granillo GA, Nieman K, Carrascosa P, Campisi R, Ambrose JA. PMID: 32180079.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    11. Misdiagnosis of Type II Myocardial Infarction. J Am Coll Cardiol. 2019 10 01; 74(13):1732-1733. Saleh MA, Ambrose JA, Poosti K, Rajyaguru C, Sargsyan M, Najafi A, Bhullar A, Sandhu U, Hashmi M, Sandhu C. PMID: 31558258.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    12. Environmental Tobacco Smoke and Cardiovascular Disease. Int J Environ Res Public Health. 2018 12 31; 16(1). DiGiacomo SI, Jazayeri MA, Barua RS, Ambrose JA. PMID: 30602668; PMCID: PMC6339042.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsPHPublic Health
    13. Understanding myocardial infarction. F1000Res. 2018; 7. Saleh M, Ambrose JA. PMID: 30228871; PMCID: PMC6124376.
      View in: PubMed   Mentions: 63     Fields:    Translation:Humans
    14. Strategies for the Prevention of Coronary Artery Disease Complications: Can We Do Better? Am J Med. 2018 09; 131(9):1003-1009. Ambrose JA, Najafi A. PMID: 29729244.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansPHPublic Health
    15. In-Hospital Outcomes of Percutaneous Coronary Intervention in America's Safety Net: Insights From the NCDR Cath-PCI Registry. JACC Cardiovasc Interv. 2017 08 14; 10(15):1475-1485. Acharya T, Salisbury AC, Spertus JA, Kennedy KF, Bhullar A, Reddy HKK, Joshi BK, Ambrose JA. PMID: 28797422.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    16. Normalization of Testosterone Levels After Testosterone Replacement Therapy Is Not Associated With Reduced Myocardial Infarction in Smokers. Mayo Clin Proc Innov Qual Outcomes. 2017 Jul; 1(1):57-66. Oni OA, Sharma R, Chen G, Sharma M, Gupta K, Dawn B, Sharma R, Parashara D, Savin VJ, Cherian G, Ambrose JA, Barua RS. PMID: 30225402; PMCID: PMC6135014.
      View in: PubMed   Mentions: 4  
    17. Normalization of Testosterone Levels After Testosterone Replacement Therapy Is Associated With Decreased Incidence of Atrial Fibrillation. J Am Heart Assoc. 2017 May 09; 6(5). Sharma R, Oni OA, Gupta K, Sharma M, Sharma R, Singh V, Parashara D, Kamalakar S, Dawn B, Chen G, Ambrose JA, Barua RS. PMID: 28487389; PMCID: PMC5524065.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    18. Finding the High-Risk Patient in Primary Prevention Is Not as Easy as a Conventional Risk Score! Am J Med. 2016 Dec; 129(12):1329.e1-1329.e7. Ambrose JA, Acharya T, Roberts MJ. PMID: 27566505.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansPHPublic Health
    19. Left Atrial Area and Right Ventricle Dimensions in Non-gated Axial Chest CT can Differentiate Pulmonary Hypertension Due to Left Heart Disease from Other Causes. J Cardiovasc Comput Tomogr. 2016 May-Jun; 10(3):246-50. Katikireddy CK, Singh M, Muhyieddeen K, Acharya T, Ambrose JA, Samim A. PMID: 26869368.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    20. Normalization of testosterone level is associated with reduced incidence of myocardial infarction and mortality in men. Eur Heart J. 2015 Oct 21; 36(40):2706-15. Sharma R, Oni OA, Gupta K, Chen G, Sharma M, Dawn B, Sharma R, Parashara D, Savin VJ, Ambrose JA, Barua RS. PMID: 26248567.
      View in: PubMed   Mentions: 91     Fields:    Translation:Humans
    21. A Single Controlled Exposure to Secondhand Smoke May Not Alter Thrombogenesis or Trigger Platelet Activation. Nicotine Tob Res. 2016 May; 18(5):580-4. Srikanth S, Sy F, Kotak K, Kiel RG, Bajwa M, Tandon A, Loures-Vale AA, Aftab W, Tringali S, Ambrose JA. PMID: 26101293.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansPHPublic HealthCTClinical Trials
    22. Pathophysiology of coronary artery disease leading to acute coronary syndromes. F1000Prime Rep. 2015; 7:08. Ambrose JA, Singh M. PMID: 25705391; PMCID: PMC4311268.
      View in: PubMed   Mentions: 52  
    23. Do advances in technology in the catheterization laboratory for percutaneous coronary interventions negatively influence an operator's technique, decision making, and judgment? JACC Cardiovasc Interv. 2014 Oct; 7(10):1198-9. Ambrose JA. PMID: 25240546.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    24. Reducing acute coronary events: the solution is not so difficult! Am J Med. 2015 Feb; 128(2):105-6. Ambrose JA, Acharya T. PMID: 25193272.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    25. Femoral micropuncture or routine introducer study (FEMORIS). Cardiology. 2014; 129(1):39-43. Ambrose JA, Lardizabal J, Mouanoutoua M, Buhari CF, Berg R, Joshi B, El-Sherief K, Wessel R, Singh M, Kiel R. PMID: 25012707.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    26. Are the culprit lesions severely stenotic? JACC Cardiovasc Imaging. 2013 Oct; 6(10):1108-1114. Niccoli G, Stefanini GG, Capodanno D, Crea F, Ambrose JA, Berg R. PMID: 24135324.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    27. Frequency of Takotsubo cardiomyopathy in postmenopausal women presenting with an acute coronary syndrome. Am J Cardiol. 2013 Aug 15; 112(4):479-82. Sy F, Basraon J, Zheng H, Singh M, Richina J, Ambrose JA. PMID: 23683950.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    28. Mechanisms of coronary thrombosis in cigarette smoke exposure. Arterioscler Thromb Vasc Biol. 2013 Jul; 33(7):1460-7. Barua RS, Ambrose JA. PMID: 23685556.
      View in: PubMed   Mentions: 79     Fields:    Translation:HumansAnimalsPHPublic Health
    29. Pathophysiology of coronary thrombus formation and adverse consequences of thrombus during PCI. Curr Cardiol Rev. 2012 Aug; 8(3):168-76. Srikanth S, Ambrose JA. PMID: 22920487; PMCID: PMC3465820.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    30. Managing coronary thrombus in the cath lab during PCI. Curr Cardiol Rev. 2012 Aug; 8(3):200-1. Ambrose JA. PMID: 23210928; PMCID: PMC3465824.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    31. Angiographic correlates in type 1 and 2 MI by the universal definition. JACC Cardiovasc Imaging. 2012 Apr; 5(4):463-4. Ambrose JA, Loures-Vale A, Javed U, Buhari CF, Aftab W. PMID: 22498337.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    32. Computed tomographic angiography for localizing the site of plaque disruption/thrombus: is detection so complex? Circ Cardiovasc Imaging. 2011 Mar; 4(2):82-3. Ambrose JA, Srikanth S. PMID: 21406660.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    33. Acute myocardial infarction and the five-chambered heart. Catheter Cardiovasc Interv. 2011 Feb 01; 77(2):228-31. Lardizabal JA, Javed U, Ambrose JA. PMID: 20853361.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    34. Does angiographic response to wiring of totally occluded vessels predict outcomes in ST-segment elevation myocardial infarction? JACC Cardiovasc Interv. 2011 Jan; 4(1):63-5. Ambrose JA, Buhari CF. PMID: 21251630.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    35. Acute cigarette smoke exposure reduces clot lysis--association between altered fibrin architecture and the response to t-PA. Thromb Res. 2010 Nov; 126(5):426-30. Barua RS, Sy F, Srikanth S, Huang G, Javed U, Buhari C, Margosan D, Aftab W, Ambrose JA. PMID: 20813396.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    36. Evaluation of plaque composition by intravascular ultrasound "virtual histology": the impact of dense calcium on the measurement of necrotic tissue. EuroIntervention. 2010 Aug; 6(3):394-9. Sales FJ, Falcão BA, Falcão JL, Ribeiro EE, Perin MA, Horta PE, Spadaro AG, Ambrose JA, Martinez EE, Furuie SS, Lemos PA. PMID: 20884420.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    37. The balance between anti-ischemic efficacy and bleeding risk of antithrombotic therapy in percutaneous coronary intervention: a Yin-Yang paradigm. J Invasive Cardiol. 2010 Jun; 22(6):284-92. Lardizabal JA, Joshi BK, Ambrose JA. PMID: 20516510.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    38. Vulnerable plaques and patients: improving prediction of future coronary events. Am J Med. 2010 Jan; 123(1):10-6. Ambrose JA, Srikanth S. PMID: 20102983.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    39. Effects of cigarette smoke exposure on clot dynamics and fibrin structure: an ex vivo investigation. Arterioscler Thromb Vasc Biol. 2010 Jan; 30(1):75-9. Barua RS, Sy F, Srikanth S, Huang G, Javed U, Buhari C, Margosan D, Ambrose JA. PMID: 19815816.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansCells
    40. Preventing future acute coronary events: is the target the so-called vulnerable plaque or the high-risk or vulnerable patient? Curr Opin Cardiol. 2009 Sep; 24(5):483-9. Ambrose JA, Srikanth S. PMID: 19550309.
      View in: PubMed   Mentions:    Fields:    Translation:HumansPHPublic Health
    41. Frequency of elevated troponin I and diagnosis of acute myocardial infarction. Am J Cardiol. 2009 Jul 01; 104(1):9-13. Javed U, Aftab W, Ambrose JA, Wessel RJ, Mouanoutoua M, Huang G, Barua RS, Weilert M, Sy F, Thatai D. PMID: 19576313.
      View in: PubMed   Mentions: 42     Fields:    Translation:Humans
    42. The editor's roundtable: the vulnerable plaque. Am J Cardiol. 2008 Dec 15; 102(12):1644-53. Friedewald VE, Ambrose JA, Stone GW, Roberts WC, Willerson JT. PMID: 19064018.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    43. In search of the "vulnerable plaque": can it be localized and will focal regional therapy ever be an option for cardiac prevention? J Am Coll Cardiol. 2008 Apr 22; 51(16):1539-42. Ambrose JA. PMID: 18420095.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    44. Methamphetamine-associated acute left ventricular dysfunction: a variant of stress-induced cardiomyopathy. Cardiology. 2008; 109(3):188-92. Srikanth S, Barua R, Ambrose J. PMID: 17728543.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    45. Myocardial ischemia and infarction. J Am Coll Cardiol. 2006 Jun 06; 47(11 Suppl):D13-7. Ambrose JA. PMID: 16750715.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    46. Impact of completeness of percutaneous coronary intervention revascularization on long-term outcomes in the stent era. Circulation. 2006 May 23; 113(20):2406-12. Hannan EL, Racz M, Holmes DR, King SB, Walford G, Ambrose JA, Sharma S, Katz S, Clark LT, Jones RH. PMID: 16702469.
      View in: PubMed   Mentions: 66     Fields:    Translation:Humans
    47. A risk score to predict in-hospital mortality for percutaneous coronary interventions. J Am Coll Cardiol. 2006 Feb 07; 47(3):654-60. Wu C, Hannan EL, Walford G, Ambrose JA, Holmes DR, King SB, Clark LT, Katz S, Sharma S, Jones RH. PMID: 16458151.
      View in: PubMed   Mentions: 38     Fields:    Translation:Humans
    48. Sirolimus- and taxol-eluting stents differ towards intimal hyperplasia and re-endothelialization. J Invasive Cardiol. 2005 Sep; 17(9):497-502. Liuzzo JP, Ambrose JA, Coppola JT. PMID: 16145242.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    49. Volume-outcome relationships for percutaneous coronary interventions in the stent era. Circulation. 2005 Aug 23; 112(8):1171-9. Hannan EL, Wu C, Walford G, King SB, Holmes DR, Ambrose JA, Sharma S, Katz S, Clark LT, Jones RH. PMID: 16103238.
      View in: PubMed   Mentions: 35     Fields:    Translation:Humans
    50. Early prognostic usefulness of C-reactive protein added to the Thrombolysis In Myocardial Infarction risk score in acute coronary syndromes. Am J Cardiol. 2005 Aug 15; 96(4):533-7. Foussas SG, Zairis MN, Lyras AG, Patsourakos NG, Tsirimpis VG, Katsaros K, Beldekos DJ, Handanis SM, Mytas DZ, Karidis KS, Tselioti PG, Prekates AA, Ambrose JA. PMID: 16098307.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    51. Proton pump inhibitors for patients with coronary artery disease associated with reduced chest pain, emergency department visits, and hospitalizations. Clin Cardiol. 2005 Aug; 28(8):369-74. Liuzzo JP, Ambrose JA, Diggs P. PMID: 16144212; PMCID: PMC6654347.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    52. Plaque rupture and intracoronary thrombus in nonculprit vessels: an eyewitness account. J Am Coll Cardiol. 2005 Mar 01; 45(5):659-60. Ambrose JA, D'Agate DJ. PMID: 15734607.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    53. Classification of systemic therapies for potential stabilization of the vulnerable plaque to prevent acute myocardial infarction. Am J Cardiol. 2005 Feb 01; 95(3):379-82. Ambrose JA, D'Agate DJ. PMID: 15670548.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    54. Preprocedural plasma C-reactive protein levels, postprocedural creatine kinase-MB release, and long-term prognosis after successful coronary stenting (four-year results from the GENERATION study). Am J Cardiol. 2005 Feb 01; 95(3):386-90. Zairis MN, Ambrose JA, Ampartzidou O, Lyras AG, Manousakis SJ, Makrygiannis SS, Beldekos DJ, Devoe MC, Fakiolas CN, Prekates AA, Olympios CD, Argyrakis SK, Foussas SG, GENERATION Study Group. PMID: 15670550.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    55. The evolving role of glycoprotein (GP) IIb/IIIa receptor blockade during percutaneous coronary intervention of saphenous vein bypass grafts. J Invasive Cardiol. 2004 Sep; 16(9):500-3. D'Agate DJ, Patel S, Coppola JT, Ambrose JA. PMID: 15353833.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    56. The pathophysiology of cigarette smoking and cardiovascular disease: an update. J Am Coll Cardiol. 2004 May 19; 43(10):1731-7. Ambrose JA, Barua RS. PMID: 15145091.
      View in: PubMed   Mentions: 689     Fields:    Translation:HumansPHPublic Health
    57. Predictors of troponin elevation after percutaneous coronary intervention. Am J Cardiol. 2004 Mar 15; 93(6):747-50. Mandadi VR, DeVoe MC, Ambrose JA, Prakash AM, Varshneya N, Gould RB, Nguyen TH, Geagea JP, Radojevic JA, Sehhat K, Barua RS. PMID: 15019883.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    58. Value of low-dose dobutamine addition to routine dual isotope gated SPECT myocardial imaging in patients with healed myocardial infarction or abnormal wall thickening by echocardiogram. Am J Cardiol. 2004 Feb 01; 93(3):300-6. Heiba SI, Abdel-Dayem HM, Gould R, Bernaski E, Morlote M, El-Zeftawy H, Ambrose JA. PMID: 14759378.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    59. Luminal recovery from six to twelve months after implantation of "thicker strut" coronary stents. Am J Cardiol. 2004 Jan 15; 93(2):210-3. Meireles GC, Lemos PA, Ambrose JA, Ribeiro E, Horta PE, Perin M, Ramires JA, Martinez EE. PMID: 14715350.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCTClinical Trials
    60. Pilot study of oral rapamycin to prevent restenosis in patients undergoing coronary stent therapy: Argentina Single-Center Study (ORAR Trial). J Invasive Cardiol. 2003 Oct; 15(10):581-4. Rodriguez AE, Alemparte MR, Vigo CF, Pereira CF, Llaurado C, Russo M, Virmani R, Ambrose JA. PMID: 14519892.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    61. Identification of vulnerable atherosclerotic plaques. Expert Rev Cardiovasc Ther. 2003 Sep; 1(3):353-65. Staniloae CS, Ambrose JA. PMID: 15030264.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    62. Frequency of and outcome of acute coronary syndromes in patients with human immunodeficiency virus infection. Am J Cardiol. 2003 Aug 01; 92(3):301-3. Ambrose JA, Gould RB, Kurian DC, DeVoe MC, Pearlstein NB, Coppola JT, Siegal FP. PMID: 12888138.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    63. Reactive oxygen species are involved in smoking-induced dysfunction of nitric oxide biosynthesis and upregulation of endothelial nitric oxide synthase: an in vitro demonstration in human coronary artery endothelial cells. Circulation. 2003 May 13; 107(18):2342-7. Barua RS, Ambrose JA, Srivastava S, DeVoe MC, Eales-Reynolds LJ. PMID: 12707237.
      View in: PubMed   Mentions: 79     Fields:    Translation:HumansCells
    64. C-reactive protein and ST-segment monitoring by continuous 12-lead electrocardiogram in patients with primary unstable angina pectoris. Am J Cardiol. 2003 Mar 01; 91(5):600-3. Zairis MN, Ambrose JA, Papadaki OA, Manousakis SJ, Stefanidis AS, DeVoe MC, Handanis SM, Olympios CD, Foussas SG. PMID: 12615271.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    65. Peripheral conduction disease in left ventricular dysfunction. Am J Cardiol. 2003 Feb 01; 91(3):354-6. Puttappa R, Raia F, Bhat S, Braff R, Mandadi VR, Barua RS, DeVoe MC, Boal BH, Ambrose JA. PMID: 12565099.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    66. Heavy and light cigarette smokers have similar dysfunction of endothelial vasoregulatory activity: an in vivo and in vitro correlation. J Am Coll Cardiol. 2002 Jun 05; 39(11):1758-63. Barua RS, Ambrose JA, Eales-Reynolds LJ, DeVoe MC, Zervas JG, Saha DC. PMID: 12039488.
      View in: PubMed   Mentions: 36     Fields:    Translation:Humans
    67. A new paradigm for plaque stabilization. Circulation. 2002 Apr 23; 105(16):2000-4. Ambrose JA, Martinez EE. PMID: 11997290.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimals
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