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Malcolm Rowland, PhD

Title(s)Professor, Bioengineering
SchoolSchool of Pharmacy
Address1700 4th Street
San Francisco CA 94158
Phone--
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    1. Intracellular and Intraorgan Concentrations of Small Molecule Drugs: Theory, Uncertainties in Infectious Diseases and Oncology, and Promise. Drug Metab Dispos. 2019 06; 47(6):665-672. Smith DA, Rowland M. PMID: 30910784.
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    2. Past, Present, and Future of Bioequivalence: Improving Assessment and Extrapolation of Therapeutic Equivalence for Oral Drug Products. J Pharm Sci. 2018 10; 107(10):2519-2530. Cristofoletti R, Rowland M, Lesko LJ, Blume H, Rostami-Hodjegan A, Dressman JB. PMID: 29935299.
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    3. Importance of target-mediated drug disposition for small molecules. Drug Discov Today. 2018 12; 23(12):2023-2030. Smith DA, van Waterschoot RAB, Parrott NJ, Olivares-Morales A, Lavé T, Rowland M. PMID: 29928850.
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    4. Impact of target interactions on small-molecule drug disposition: an overlooked area. Nat Rev Drug Discov. 2018 04; 17(4):299. van Waterschoot RAB, Parrott NJ, Olivares-Morales A, Lavé T, Rowland M, Smith DA. PMID: 29472637.
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    5. Physiologically Based Pharmacokinetic Model Qualification and Reporting Procedures for Regulatory Submissions: A Consortium Perspective. Clin Pharmacol Ther. 2018 07; 104(1):88-110. Shebley M, Sandhu P, Emami Riedmaier A, Jamei M, Narayanan R, Patel A, Peters SA, Reddy VP, Zheng M, de Zwart L, Beneton M, Bouzom F, Chen J, Chen Y, Cleary Y, Collins C, Dickinson GL, Djebli N, Einolf HJ, Gardner I, Huth F, Kazmi F, Khalil F, Lin J, Odinecs A, Patel C, Rong H, Schuck E, Sharma P, Wu SP, Xu Y, Yamazaki S, Yoshida K, Rowland M. PMID: 29315504.
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    6. Commentary on "The Universally Unrecognized Assumption in Predicting Drug Clearance and Organ Extraction Ratio". Clin Pharmacol Ther. 2018 03; 103(3):386-388. Rowland M, Pang KS. PMID: 29134634.
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    7. Are Physiologically Based Pharmacokinetic Models Reporting the Right C(max)? Central Venous Versus Peripheral Sampling Site. AAPS J. 2015 Sep; 17(5):1268-79. Musther H, Gill KL, Chetty M, Rostami-Hodjegan A, Rowland M, Jamei M. PMID: 26100012.
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    8. Disposition kinetics of diclofenac in the dual perfused rat liver. J Pharm Sci. 2013 Sep; 102(9):3220-7. Sahin S, Rowland M. PMID: 23613004.
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    9. Cyclosporine inhibition of hepatic and intestinal CYP3A4, uptake and efflux transporters: application of PBPK modeling in the assessment of drug-drug interaction potential. Pharm Res. 2013 Mar; 30(3):761-80. Gertz M, Cartwright CM, Hobbs MJ, Kenworthy KE, Rowland M, Houston JB, Galetin A. PMID: 23179780.
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    10. Tissue lipids and drug distribution: dog versus rat. J Pharm Sci. 2012 Dec; 101(12):4615-26. Rodgers T, Jones HM, Rowland M. PMID: 22961739.
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    11. Microdosing: a critical assessment of human data. J Pharm Sci. 2012 Nov; 101(11):4067-74. Rowland M. PMID: 22927093.
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    12. Impact of the pharmaceutical sciences on health care: a reflection over the past 50 years. J Pharm Sci. 2012 Nov; 101(11):4075-99. Rowland M, Noe CR, Smith DA, Tucker GT, Crommelin DJ, Peck CC, Rocci ML, Besançon L, Shah VP. PMID: 22911654.
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    13. Dedication to professor Leslie Z. Benet: 50 years of scientific excellence and still going strong! Pharm Res. 2012 Sep; 29(9):2345-53. Smith DE, Rowland M, Giacomini KM, Amidon GL. PMID: 22814901.
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    14. Toward an integrated human clearance prediction strategy that minimizes animal use. J Pharm Sci. 2011 Oct; 100(10):4518-35. Beaumont K, Gardner I, Chapman K, Hall M, Rowland M. PMID: 21710508.
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    15. Lead PK commentary: predicting human pharmacokinetics. J Pharm Sci. 2011 Oct; 100(10):4047-9. Rowland M, Benet LZ. PMID: 21630278.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    16. PhRMA CPCDC initiative on predictive models of human pharmacokinetics, part 3: comparative assessement of prediction methods of human clearance. J Pharm Sci. 2011 Oct; 100(10):4090-110. Ring BJ, Chien JY, Adkison KK, Jones HM, Rowland M, Jones RD, Yates JW, Ku MS, Gibson CR, He H, Vuppugalla R, Marathe P, Fischer V, Dutta S, Sinha VK, Björnsson T, Lavé T, Poulin P. PMID: 21541938.
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    17. PHRMA CPCDC initiative on predictive models of human pharmacokinetics, part 5: prediction of plasma concentration-time profiles in human by using the physiologically-based pharmacokinetic modeling approach. J Pharm Sci. 2011 Oct; 100(10):4127-57. Poulin P, Jones RD, Jones HM, Gibson CR, Rowland M, Chien JY, Ring BJ, Adkison KK, Ku MS, He H, Vuppugalla R, Marathe P, Fischer V, Dutta S, Sinha VK, Björnsson T, Lavé T, Yates JW. PMID: 21541937.
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    18. PhRMA CPCDC initiative on predictive models of human pharmacokinetics, part 2: comparative assessment of prediction methods of human volume of distribution. J Pharm Sci. 2011 Oct; 100(10):4074-89. Jones RD, Jones HM, Rowland M, Gibson CR, Yates JW, Chien JY, Ring BJ, Adkison KK, Ku MS, He H, Vuppugalla R, Marathe P, Fischer V, Dutta S, Sinha VK, Björnsson T, Lavé T, Poulin P. PMID: 21452299.
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    19. Physiologically-based pharmacokinetics in drug development and regulatory science. Annu Rev Pharmacol Toxicol. 2011; 51:45-73. Rowland M, Peck C, Tucker G. PMID: 20854171.
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    20. Use of dried blood spots in drug development: pharmacokinetic considerations. AAPS J. 2010 Sep; 12(3):290-3. Rowland M, Emmons GT. PMID: 20383669.
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    21. Interview: Interview with Professor Malcolm Rowland. Bioanalysis. 2010 Mar; 2(3):385-91. Rowland M. PMID: 21083248.
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    22. Commentary on ACCP position statement on the use of microdosing in the drug development process. J Clin Pharmacol. 2007 Dec; 47(12):1595-6; author reply 1597-8. Rowland M. PMID: 18048576.
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    23. Pharmacokinetic modelling of interleukin-1 receptor antagonist in plasma and cerebrospinal fluid of patients following subarachnoid haemorrhage. Br J Clin Pharmacol. 2008 Mar; 65(3):317-25. Gueorguieva I, Clark SR, McMahon CJ, Scarth S, Rothwell NJ, Tyrrell PJ, Tyrell PJ, Hopkins SJ, Rowland M. PMID: 17875190.
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    24. Mechanistic approaches to volume of distribution predictions: understanding the processes. Pharm Res. 2007 May; 24(5):918-33. Rodgers T, Rowland M. PMID: 17372687.
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    25. Diazepam pharamacokinetics from preclinical to phase I using a Bayesian population physiologically based pharmacokinetic model with informative prior distributions in WinBUGS. J Pharmacokinet Pharmacodyn. 2006 Oct; 33(5):571-94. Gueorguieva I, Aarons L, Rowland M. PMID: 16810558.
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    26. Editorial to the second issue dedicated to Lewis Sheiner. J Pharmacokinet Pharmacodyn. 2006 Jun; 33(3):223-5. Rowland M. PMID: 16683187.
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    27. Physiologically based pharmacokinetic modelling 2: predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions. J Pharm Sci. 2006 Jun; 95(6):1238-57. Rodgers T, Rowland M. PMID: 16639716.
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    28. Optimal design for multivariate response pharmacokinetic models. J Pharmacokinet Pharmacodyn. 2006 Apr; 33(2):97-124. Gueorguieva I, Aarons L, Ogungbenro K, Jorga KM, Rodgers T, Rowland M. PMID: 16550455.
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    29. Reducing whole body physiologically based pharmacokinetic models using global sensitivity analysis: diazepam case study. J Pharmacokinet Pharmacodyn. 2006 Feb; 33(1):1-27. Gueorguieva I, Nestorov IA, Rowland M. PMID: 16369700.
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    30. A comment on the "correction" of tissue-plasma partition coefficients for drug extraction in eliminating organs by Sven Björkman. J Pharmacokinet Pharmacodyn. 2005 Dec; 32(5-6):659-62. Gueorguieva I, Rowland M. PMID: 16307205.
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    31. Uncertainty analysis in pharmacokinetics and pharmacodynamics: application to naratriptan. Pharm Res. 2005 Oct; 22(10):1614-26. Gueorguieva I, Nestorov IA, Aarons L, Rowland M. PMID: 16180118.
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    32. The pharmacokinetics of perindoprilat in normal volunteers and patients: influence of age and disease state. Eur J Pharm Sci. 2005 Sep; 26(1):104-13. Parker E, Aarons L, Rowland M, Resplandy G. PMID: 15982858.
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    33. Physiologically based pharmacokinetic modeling 1: predicting the tissue distribution of moderate-to-strong bases. J Pharm Sci. 2005 Jun; 94(6):1259-76. Rodgers T, Leahy D, Rowland M. PMID: 15858854.
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    34. Tissue distribution of basic drugs: accounting for enantiomeric, compound and regional differences amongst beta-blocking drugs in rat. J Pharm Sci. 2005 Jun; 94(6):1237-48. Rodgers T, Leahy D, Rowland M. PMID: 15858851.
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    35. Editorial to the first issue dedicated to Lewis Sheiner. J Pharmacokinet Pharmacodyn. 2005 Apr; 32(2):157-9. Rowland M. PMID: 16307212.
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    36. Development of a whole body physiologically based model to characterise the pharmacokinetics of benzodiazepines. 1: Estimation of rat tissue-plasma partition ratios. J Pharmacokinet Pharmacodyn. 2004 Aug; 31(4):269-98. Gueorguieva I, Nestorov IA, Murby S, Gisbert S, Collins B, Dickens K, Duffy J, Hussain Z, Rowland M. PMID: 15563004.
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    37. Fuzzy simulation of pharmacokinetic models: case study of whole body physiologically based model of diazepam. J Pharmacokinet Pharmacodyn. 2004 Jun; 31(3):185-213. Gueorguieva II, Nestorov IA, Rowland M. PMID: 15518244.
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    38. Physiologically based pharmacokinetics in drug development and regulatory science: a workshop report (Georgetown University, Washington, DC, May 29-30, 2002). AAPS PharmSci. 2004 Feb 09; 6(1):E6. Rowland M, Balant L, Peck C. PMID: 15198507.
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    39. A Bayesian method based on clotting factor activity for the prediction of maintenance warfarin dosage regimens. Ther Drug Monit. 2003 Feb; 25(1):36-40. Pitsiu M, Parker EM, Aarons L, Rowland M. PMID: 12548142.
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    40. Incorporating measures of variability and uncertainty into the prediction of in vivo hepatic clearance from in vitro data. Drug Metab Dispos. 2002 Mar; 30(3):276-82. Nestorov I, Gueorguieva I, Jones HM, Houston B, Rowland M. PMID: 11854145.
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