Nyarie Sithole, PhD, MSc

Title(s)Visiting Scholar, Medicine
SchoolSchool of Medicine
ORCID ORCID Icon0000-0002-8020-223X Additional info
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    Collapse Biography 
    Collapse Education and Training
    University of Cambridge, Cambridge, United KingdomPhD05/2017Doctor of Philosophy in Medicine
    Royal College of Physicians, London, London, United KingdomFRCPMedicine
    University of Liverpool,, Liverpool, United KingdomMScMSc Infectious Diseases and Tropical Medicine
    Oxford University Teaching Hospital, Oxford, UKGeneral Internal Medicine
    University of Zimbabwe Medical School, Harare, ZimbabweMBChBMedicine and Surgery
    Collapse Awards and Honors
    University of Cambridge, UK2023Wellcome Trust Research Career Development Award
    University of Cambridge, UK2019  - 2021NIHR Academic Clinical Lecturer, Infectious Diseases
    University of Cambridge, UK2013  - 2016Wellcome Trust Clinical Research Fellowship
    Liverpool School of Tropical Medicine2008  - 2008Glen Williams Award, Best MSc Student
    Liverpool School of Tropical Medicine2008  - 2009British Chevening Scholarship
    University of Cambridge, UK2010  - 2011Evelyn Research Fellowship
    Oxford University Teaching Hospital2012Teacher of the Month - June

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Mechanisms of antibody mediated protection against Mycobacterium tuberculosis
    Wellcome Trust Jun 1, 2023 - Jul 1, 2028
    Role: PI
    Description: Almost all effective vaccines rely on antibody-mediated immunity. Despite increasing evidence that antibodies play a role in immunity to tuberculosis (TB), the current pipeline of TB vaccine candidates has focused on eliciting cellular immunity. One critical bottleneck that prevent maximising the utility of antibody-mediated immunity for novel TB vaccines is lack of understanding how antibodies protect against infection by M. tuberculosis (Mtb). Using single-cell RNA sequencing, I will identify the cellular phenotypes and spatial organisation associated with antibody-mediated protection. Finally, I will investigate the role of activatory and inhibitory Fc receptor signalling in mediating antibody-mediated protection. Taken together, the proposed studies will help rationally improve future TB vaccines.

    Collapse ORNG Applications 
    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Spontaneous, persistent, T cell-dependent IFN-γ release in patients who progress to Long Covid. Sci Adv. 2024 Feb 23; 10(8):eadi9379. Krishna BA, Lim EY, Metaxaki M, Jackson S, Mactavous L, NIHR BioResource, Lyons PA, Doffinger R, Bradley JR, Smith KGC, Sinclair J, Matheson NJ, Lehner PJ, Sithole N, Wills MR. PMID: 38381822; PMCID: PMC10881041.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    2. Long COVID: what is known and what gaps need to be addressed. Br Med Bull. 2023 09 12; 147(1):6-19. Krishna B, Wills M, Sithole N. PMID: 37434326; PMCID: PMC10502447.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    3. Hospitalisation for COVID-19 predicts long lasting cerebrovascular impairment: A prospective observational cohort study. 2023. Tsvetanov KA, …. Rowe, JB., Menon, DK., *The Cambridge NeuroCOVID Group, . View Publication.
    4. Reduced Incidence of Long Coronavirus Disease Referrals to the Cambridge University Teaching Hospital Long Coronavirus Disease Clinic. Clin Infect Dis. 2023 02 18; 76(4):738-740. Krishna BA, Metaxaki M, Wills MR, Sithole N. PMID: 35913432; PMCID: PMC9384550.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    5. Oseltamivir is protective for in-patient mortality in PCR confirmed influenza B and influenza A(H3N2) infections in an historic cohort of 1,048 patients hospitalised during the 2016-17 and 2017-18  influenza seasons. J Infect. 2023 03; 86(3):256-308. Reacher M, Warne B, Verlander NQ, Popay A, Reeve L, Jones NK, Ranellou K, Sithole N, Carpenter R, Everden A, Jarman E, Khalid A, Lam K, Myers C, Ren S, Rolfe KJ, Sutton T, Christou S, Wright C, Choudhry S, Zambon M, Sander C, Zhang H, Jalal H. PMID: 36646142.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    6. Brain injury in COVID-19 is associated with dysregulated innate and adaptive immune responses. Brain. 2022 11 21; 145(11):4097-4107. Needham EJ, Ren AL, Digby RJ, Norton EJ, Ebrahimi S, Outtrim JG, Chatfield DA, Manktelow AE, Leibowitz MM, Newcombe VFJ, Doffinger R, Barcenas-Morales G, Fonseca C, Taussig MJ, Burnstein RM, Samanta RJ, Dunai C, Sithole N, Ashton NJ, Zetterberg H, Gisslén M, Edén A, Marklund E, Openshaw PJM, Dunning J, Griffiths MJ, Cavanagh J, Breen G, Irani SR, Elmer A, Kingston N, Summers C, Bradley JR, Taams LS, Michael BD, Bullmore ET, Smith KGC, Lyons PA, Coles AJ, Menon DK, Cambridge NeuroCOVID Group, CITIID-NIHR COVID-19 BioResource Collaboration, Cambridge NIHR Clinical Research Facility. PMID: 36065116; PMCID: PMC9494359.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    7. Demographic, behavioural and occupational risk factors associated with SARS-CoV-2 infection in UK healthcare workers: a retrospective observational study. BMJ Open. 2022 11 07; 12(11):e063159. Cooper DJ, Lear S, Sithole N, Shaw A, Stark H, Ferris M, CITIID-NIHR BioResource COVID-19 collaboration consortium, Bradley J, Maxwell P, Goodfellow I, Weekes MP, Seaman S, Baker S. PMID: 36343994; PMCID: PMC9644078.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    8. Evidence of previous SARS-CoV-2 infection in seronegative patients with long COVID. EBioMedicine. 2022 Jul; 81:104129. Krishna BA, Lim EY, Mactavous L, NIHR BioResource Team, Lyons PA, Doffinger R, Bradley JR, Smith KGC, Sinclair J, Matheson NJ, Lehner PJ, Wills MR, Sithole N. PMID: 35772216; PMCID: PMC9235296.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    9. Investigation of healthcare-associated SARS-CoV-2 infection: Learning outcomes from an investigative process in the initial phase of the pandemic. J Infect Prev. 2022 Sep; 23(5):197-205. Ramsay I, Sharrocks K, Warne B, Sithole N, Ravji P, Bousfield R, Jones N, Leong CE, Suliman M, Tsui R, Toleman MS, Moody C, Smith R, Whitehorn J, Gouliouris T, Penciu F, Hofling C, Cunningham C, Enoch DA, Moore E. PMID: 36003131; PMCID: PMC9117956.
      View in: PubMed   Mentions: 1  
    10. Multivariate profile and acute-phase correlates of cognitive deficits in a COVID-19 hospitalised cohort. EClinicalMedicine. 2022 May; 47:101417. Hampshire A, Chatfield DA, MPhil AM, Jolly A, Trender W, Hellyer PJ, Giovane MD, Newcombe VFJ, Outtrim JG, Warne B, Bhatti J, Pointon L, Elmer A, Sithole N, Bradley J, Kingston N, Sawcer SJ, Bullmore ET, Rowe JB, Menon DK, Cambridge NeuroCOVID Group, the NIHR COVID-19 BioResource, and Cambridge NIHR Clinical Research Faci. PMID: 35505938; PMCID: PMC9048584.
      View in: PubMed   Mentions: 26  
    11. The great imitator: neurosyphilis presenting as subacute confusion. Br J Hosp Med (Lond). 2021 Jun 02; 82(6):1-3. G N, Moore E, Sithole N. PMID: 34191565.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    12. Point of Care Nucleic Acid Testing for SARS-CoV-2 in Hospitalized Patients: A Clinical Validation Trial and Implementation Study. Cell Rep Med. 2020 08 25; 1(5):100062. Collier DA, Assennato SM, Warne B, Sithole N, Sharrocks K, Ritchie A, Ravji P, Routledge M, Sparkes D, Skittrall J, Smielewska A, Ramsey I, Goel N, Curran M, Enoch D, Tassell R, Lineham M, Vaghela D, Leong C, Mok HP, Bradley J, Smith KGC, Mendoza V, Demiris N, Besser M, Dougan G, Lehner PJ, Siedner MJ, Zhang H, Waddington CS, Lee H, Gupta RK, CITIID-NIHR COVID BioResource Collaboration. PMID: 32838340; PMCID: PMC7362826.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCellsPHPublic HealthCTClinical Trials
    13. DDX5 potentiates HIV-1 transcription as a co-factor of Tat. Retrovirology. 2020 03 30; 17(1):6. Sithole N, Williams CA, Abbink TEM, Lever AML. PMID: 32228614; PMCID: PMC7106839.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    14. DDX17 Specifically, and Independently of DDX5, Controls Use of the HIV A4/5 Splice Acceptor Cluster and Is Essential for Efficient Replication of HIV. J Mol Biol. 2018 09 14; 430(18 Pt B):3111-3128. Sithole N, Williams CA, Vaughan AM, Kenyon JC, Lever AML. PMID: 30131116; PMCID: PMC6119765.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    15. The roles of DEAD box helicases in the life cycle of HIV-1. Lancet. 2015 Feb 26; 385 Suppl 1:S89. Sithole N, Williams C, Vaughan A, Lever A. PMID: 26312911.
      View in: PubMed   Mentions: 4     Fields:    
    16. Changing Epidemiology of Rotavirus Diarrhoea in Northeast Brazil after the introduction of national rotavirus vaccination. 2010. Sithole Nyaradzai.