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Raphael Hirsch, MD

Photo of Raphael Hirsch, MD
Title(s)Professor, Pediatrics
SchoolSchool of Medicine
Address550 16th Street, #4406
San Francisco CA 94158
Phone415-476-9181
Emailraphael.hirsch@ucsf.edu
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    Other Positions
    Title(s)Chair, Department of Pediatrics

    Title(s)W.H. and Marie Wattis Distinguished Professor in Pediatrics

    Title(s)Physician-in-Chief, Benioff Children’s Hospitals


    Collapse Biography 
    Collapse education and training
    University of California, San Francisco, CA09/2022Diversity, Equity, and Inclusion Champion Training

    Collapse Overview 
    Collapse overview
    Raphael Hirsch, MD, is Chair of the UCSF Department of Pediatrics, a role he has held since 2019. Dr. Hirsch is also physician-in-chief at UCSF Benioff Children's Hospitals. Hirsch has articulated a vision for the UCSF pediatric program to be among the best in the nation, with the overarching goal of making the world a better place for all children.

    Dr. Hirsch works to grow research and expand the institution's clinical outreach to better serve the region's communities. Among his guiding principles is the belief that academic medical centers must demonstrate a commitment to social justice.

    After earning his bachelor's degree at Northwestern University, Hirsch earned his medical degree from the University of Illinois at Chicago. He completed a residency in pediatrics at the University of Minnesota at Minneapolis, followed by a post-doctoral fellowship in immunology at the National Institutes of Health (NIH) and a pediatric rheumatology fellowship at Children's National Hospital in Washington, D.C.

    From 2012 to 2019, Hirsch served as Department Executive Officer and Chair of the Department of Pediatrics at the University of Iowa and as physician-in-chief at University of Iowa Stead Family Children's Hospital. He was responsible for pediatric services, including patient care, education, research and public health, both at the collegiate level and for the health system. During this time, he helped direct a transformation of the pediatric medicine program, spurred by construction of the first freestanding children's hospital for the University of Iowa.

    Prior to his work at the University of Iowa, Dr. Hirsch served for 10 years as Chief of the Division of Pediatric Rheumatology and Vice Chair for Faculty Development at UPMC Children's Hospital of Pittsburgh and the University of Pittsburgh School of Medicine. Under his leadership, the division grew from a single clinician into one of the largest and most comprehensive programs in the country.

    Dr. Hirsch has held numerous leadership positions in the American College of Rheumatology, most recently as a member of its board of directors. He served on the board of scientific counselors for the National Institute of Arthritis and Musculoskeletal and Skin Diseases, a branch of the NIH. His research has sought a better understanding of childhood rheumatic diseases, with the goal of developing improved therapies, and was funded by the NIH for more than 25 years. He has published nearly 100 scientific papers.

    Collapse Research 
    Collapse research activities and funding
    The Child Health Research Career Development Program at UCSF
    NIH K12HD105250Apr 1, 2021 - Mar 31, 2026
    Role: Principal Investigator
    USE OF THERMAL AND 3D IMAGING TO QUANTIFY ARTHRITIS
    NIH R21AR056690Apr 15, 2009 - Mar 31, 2012
    Role: Principal Investigator
    Characterization of a novel T cell activating protein in arthritis
    NIH R01AR056959Apr 1, 2009 - Jan 31, 2014
    Role: Principal Investigator
    Role of FSTL-1 in Arthritis
    NIH R01AI073556Jul 1, 2008 - Jun 30, 2012
    Role: Principal Investigator
    Adeno-Associated Virus-Mediated Synovial Gene Transfer
    NIH R01AR044566Sep 10, 1996 - Aug 31, 2007
    Role: Principal Investigator
    MHC IG FUSION PROTEINS EFFECTS ON T CELL FUNCTION
    NIH R01AI034958Dec 1, 1993 - Jun 30, 2005
    Role: Principal Investigator
    IN VIVO ANERGY INDUCTION WITH NONMITOGENIC ANTI-TCR MAB
    NIH R29AI034958Dec 1, 1993 - Nov 30, 1998
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Supporting Career Transitions of Senior Faculty: Perspectives of Chairs and Full Professors. J Pediatr. 2024 Jan; 264:113518. Tolleson-Rinehart S, Rosenthal SL, de Roche AM, Laughon M, Sewell TB, Rivera CM, Gozal D, Hirsch R, Orange JS, Davis SD. PMID: 37244584.
      View in: PubMed   Mentions:
    2. Regulation of Pulmonary Bacterial Immunity by Follistatin-Like Protein 1. Infect Immun. 2020 Dec 15; 89(1). Henkel M, Dutta JA, Partyka J, Eddens T, Hirsch R, Kolls JK, Campfield BT. PMID: 33077624; PMCID: PMC7927939.
      View in: PubMed   Mentions:
    3. The Follistatin-like Protein 1 Pathway Is Important for Maintaining Healthy Articular Cartilage. ACR Open Rheumatol. 2020 Jul; 2(7):407-414. Chaly Y, Hostager B, Smith S, Hirsch R. PMID: 32530126; PMCID: PMC7368136.
      View in: PubMed   Mentions:
    4. FSTL-1 Attenuation Causes Spontaneous Smoke-Resistant Pulmonary Emphysema. Am J Respir Crit Care Med. 2020 Apr 15; 201(8):934-945. Henkel M, Partyka J, Gregory AD, Forno E, Cho MH, Eddens T, Tout AR, Salamacha N, Horne W, Rao KS, Wu Y, Alcorn JF, Kostka D, Hirsch R, Celedón JC, Shapiro SD, Kolls JK, Campfield BT. PMID: 31834999; PMCID: PMC7159415.
      View in: PubMed   Mentions:
    5. Expanding the Pipeline for Pediatric Physician-Scientists. J Pediatr. 2019 Apr; 207:3-7.e1. Dermody TS, Hirsch R, Hostetter MK, Orange JS, St Geme JW. PMID: 30922503.
      View in: PubMed   Mentions:
    6. Follistatin-like protein 1 modulates IL-17 signaling via IL-17RC regulation in stromal cells. Immunol Cell Biol. 2017 Sep; 95(8):656-665. Campfield BT, Eddens T, Henkel M, Majewski M, Horne W, Chaly Y, Gaffen SL, Hirsch R, Kolls JK. PMID: 28377613; PMCID: PMC5609702.
      View in: PubMed   Mentions:
    7. Suppression of arthritis-induced bone erosion by a CRAC channel antagonist. RMD Open. 2016; 2(1):e000093. Blair HC, Soboloff J, Robinson LJ, Tourkova IL, Larrouture QC, Witt MR, Holaskova I, Schafer R, Elliott M, Hirsch R, Barnett JB. PMID: 26819750; PMCID: PMC4716559.
      View in: PubMed   Mentions:
    8. Follistatin-like protein 1 and its role in inflammation and inflammatory diseases. Immunol Res. 2014 Aug; 59(1-3):266-72. Chaly Y, Hostager B, Smith S, Hirsch R. PMID: 24838142.
      View in: PubMed   Mentions:
    9. Follistatin-like protein 1 is a critical mediator of experimental Lyme arthritis and the humoral response to Borrelia burgdorferi infection. Microb Pathog. 2014 Aug; 73:70-9. Campfield BT, Nolder CL, Marinov A, Bushnell D, Davis A, Spychala C, Hirsch R, Nowalk AJ. PMID: 24768929; PMCID: PMC4899828.
      View in: PubMed   Mentions:
    10. Follistatin-like protein 1 regulates chondrocyte proliferation and chondrogenic differentiation of mesenchymal stem cells. Ann Rheum Dis. 2015 Jul; 74(7):1467-73. Chaly Y, Blair HC, Smith SM, Bushnell DS, Marinov AD, Campfield BT, Hirsch R. PMID: 24641944.
      View in: PubMed   Mentions:
    11. Follistatin-like protein 1 enhances NLRP3 inflammasome-mediated IL-1ß secretion from monocytes and macrophages. Eur J Immunol. 2014 May; 44(5):1467-79. Chaly Y, Fu Y, Marinov A, Hostager B, Yan W, Campfield B, Kellum JA, Bushnell D, Wang Y, Vockley J, Hirsch R. PMID: 24470197; PMCID: PMC4004659.
      View in: PubMed   Mentions:
    12. Follistatin-like protein 1 and the ferritin/erythrocyte sedimentation rate ratio are potential biomarkers for dysregulated gene expression and macrophage activation syndrome in systemic juvenile idiopathic arthritis. J Rheumatol. 2013 Jul; 40(7):1191-9. Gorelik M, Fall N, Altaye M, Barnes MG, Thompson SD, Grom AA, Hirsch R. PMID: 23678162; PMCID: PMC3885333.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    13. Do patients with juvenile idiopathic arthritis in clinical remission have evidence of persistent inflammation on 3T magnetic resonance imaging? Arthritis Care Res (Hoboken). 2012 Dec; 64(12):1846-54. Brown A, Hirsch R, Laor T, Hannon MJ, Levesque MC, Starz T, Francis K, Kwoh CK. PMID: 22740386; PMCID: PMC4398346.
      View in: PubMed   Mentions:
    14. The DBA/1 strain is a novel mouse model for experimental Borrelia burgdorferi infection. Clin Vaccine Immunol. 2012 Oct; 19(10):1567-73. Campfield BT, Nolder CL, Davis A, Hirsch R, Nowalk AJ. PMID: 22855391; PMCID: PMC3485876.
      View in: PubMed   Mentions:
    15. 2011 Pediatric Rheumatology Symposium sponsored by the American College of Rheumatology Miami, FL, USA. 2-5 June 2011. Abstracts. Pediatr Rheumatol Online J. 2012 Jul 09; 10 Suppl 1(Suppl 1):A1-A124. Gorelik M, Wilson D, Shulman S, Hirsch R. PMID: 22817878; PMCID: PMC3402995.
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    16. Plasma follistatin-like protein 1 is elevated in Kawasaki disease and may predict coronary artery aneurysm formation. J Pediatr. 2012 Jul; 161(1):116-9. Gorelik M, Wilson DC, Cloonan YK, Shulman ST, Hirsch R. PMID: 22316625; PMCID: PMC3349793.
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    17. FSTL1 promotes arthritis in mice by enhancing inflammatory cytokine/chemokine expression. Arthritis Rheum. 2012 Apr; 64(4):1082-8. Chaly Y, Marinov AD, Oxburgh L, Bushnell DS, Hirsch R. PMID: 22006268; PMCID: PMC3276726.
      View in: PubMed   Mentions:
    18. Akt fine-tunes NF-?B-dependent gene expression during T cell activation. J Biol Chem. 2011 Oct 14; 286(41):36076-36085. Cheng J, Phong B, Wilson DC, Hirsch R, Kane LP. PMID: 21862580; PMCID: PMC3195567.
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    19. Hypocomplementemia associated with macrophage activation syndrome in systemic juvenile idiopathic arthritis and adult onset still's disease: 3 cases. J Rheumatol. 2011 Feb; 38(2):396-7. Gorelik M, Torok KS, Kietz DA, Hirsch R. PMID: 21285182; PMCID: PMC3672253.
      View in: PubMed   Mentions:
    20. Follistatin-like protein 1 is a mesenchyme-derived inflammatory protein and may represent a biomarker for systemic-onset juvenile rheumatoid arthritis. Arthritis Rheum. 2010 Aug; 62(8):2510-6. Wilson DC, Marinov AD, Blair HC, Bushnell DS, Thompson SD, Chaly Y, Hirsch R. PMID: 20506332; PMCID: PMC2921021.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    21. Synovial fluid proteins differentiate between the subtypes of juvenile idiopathic arthritis. Arthritis Rheum. 2010 Jun; 62(6):1813-23. Rosenkranz ME, Wilson DC, Marinov AD, Decewicz A, Grof-Tisza P, Kirchner D, Giles B, Reynolds PR, Liebman MN, Kolli VS, Thompson SD, Hirsch R. PMID: 20222116; PMCID: PMC2918379.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    22. Pediatric pigmented villonodular synovitis mimicking a septic hip. J Clin Rheumatol. 2010 Mar; 16(2):71-3. Patel AM, Brown AG, Galambos C, Hirsch R. PMID: 20216127; PMCID: PMC3947543.
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    23. Loeys-Dietz syndrome in pregnancy: a case description and report of a novel mutation. Fetal Diagn Ther. 2009; 26(1):35-7. Gutman G, Baris HN, Hirsch R, Mandel D, Yaron Y, Lessing JB, Kuperminc MJ. PMID: 19816028.
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    24. Follistatin-like protein 1 promotes arthritis by up-regulating IFN-gamma. J Immunol. 2009 Jan 01; 182(1):234-9. Clutter SD, Wilson DC, Marinov AD, Hirsch R. PMID: 19109154; PMCID: PMC3150499.
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    25. Is long-term etanercept therapy safe and effective in patients with juvenile RA? Nat Clin Pract Rheumatol. 2008 Dec; 4(12):628-9. Hirsch R. PMID: 18852716.
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    26. Three-dimensional and thermal surface imaging produces reliable measures of joint shape and temperature: a potential tool for quantifying arthritis. Arthritis Res Ther. 2008; 10(1):R10. Spalding SJ, Kwoh CK, Boudreau R, Enama J, Lunich J, Huber D, Denes L, Hirsch R. PMID: 18215307; PMCID: PMC2374475.
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    27. Gene therapy for arthritis. Mod Rheumatol. 2008; 18(1):2-14. Traister RS, Hirsch R. PMID: 18176779; PMCID: PMC2275302.
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    28. Staphylococcus aureus panniculitis complicating juvenile dermatomyositis. Pediatrics. 2007 Feb; 119(2):e528-30. Spalding SJ, Meza MP, Ranganathan S, Hirsch R. PMID: 17261618.
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    29. Follistatin-like protein-1 is a novel proinflammatory molecule. J Immunol. 2006 Oct 01; 177(7):4758-62. Miyamae T, Marinov AD, Sowders D, Wilson DC, Devlin J, Boudreau R, Robbins P, Hirsch R. PMID: 16982916.
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    30. Inflammatory cytokine regulation of transgene expression in human fibroblast-like synoviocytes infected with adeno-associated virus. Arthritis Rheum. 2006 Jul; 54(7):2119-26. Traister RS, Fabre S, Wang Z, Xiao X, Hirsch R. PMID: 16802345.
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    31. NOD.c3c4 congenic mice develop autoimmune biliary disease that serologically and pathogenetically models human primary biliary cirrhosis. J Exp Med. 2006 May 15; 203(5):1209-19. Irie J, Wu Y, Wicker LS, Rainbow D, Nalesnik MA, Hirsch R, Peterson LB, Leung PS, Cheng C, Mackay IR, Gershwin ME, Ridgway WM. PMID: 16636131; PMCID: PMC2121204.
      View in: PubMed   Mentions: 73     Fields:    Translation:HumansAnimalsCells
    32. A soluble divalent class I MHC/IgG1 fusion protein activates CD8+ T cells in vivo. Clin Immunol. 2005 Jul; 116(1):65-76. Carey B, DeLay M, Strasser JE, Chalk C, Dudley-McClain K, Milligan GN, Brunner HI, Thornton S, Hirsch R. PMID: 15925833.
      View in: PubMed   Mentions:
    33. Serum protein profile in systemic-onset juvenile idiopathic arthritis differentiates response versus nonresponse to therapy. Arthritis Res Ther. 2005; 7(4):R746-55. Miyamae T, Malehorn DE, Lemster B, Mori M, Imagawa T, Yokota S, Bigbee WL, Welsh M, Klarskov K, Nishomoto N, Vallejo AN, Hirsch R. PMID: 15987476; PMCID: PMC1175022.
      View in: PubMed   Mentions:
    34. Proteasome inhibition enhances AAV-mediated transgene expression in human synoviocytes in vitro and in vivo. Mol Ther. 2005 Apr; 11(4):600-7. Jennings K, Miyamae T, Traister R, Marinov A, Katakura S, Sowders D, Trapnell B, Wilson JM, Gao G, Hirsch R. PMID: 15771962.
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    35. Recombinant adeno-associated virus preferentially transduces human, compared to mouse, synovium: implications for arthritis therapy. Mod Rheumatol. 2004; 14(1):18-24. Katakura S, Jennings K, Watanabe S, Adachi E, Thornton S, Gao GP, Wilson JM, Burstein H, Trapnell B, Hirsch R. PMID: 17028800.
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    36. DNA microarray analysis reveals novel gene expression profiles in collagen-induced arthritis. Clin Immunol. 2002 Nov; 105(2):155-68. Thornton S, Sowders D, Aronow B, Witte DP, Brunner HI, Giannini EH, Hirsch R. PMID: 12482389.
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    37. Gene transfer of a fibronectin peptide inhibits leukocyte recruitment and suppresses inflammation in mouse collagen-induced arthritis. Arthritis Rheum. 2002 Apr; 46(4):1102-8. Imagawa T, Watanabe S, Katakura S, Boivin GP, Hirsch R. PMID: 11953990.
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    38. A single-chain class II MHC-IgG3 fusion protein inhibits autoimmune arthritis by induction of antigen-specific hyporesponsiveness. J Immunol. 2002 Mar 01; 168(5):2554-9. Zuo L, Cullen CM, DeLay ML, Thornton S, Myers LK, Rosloniec EF, Boivin GP, Hirsch R. PMID: 11859151.
      View in: PubMed   Mentions:
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