Susan Zhang, MD, PhD
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Title(s) | Assistant Clinical Professor, Medicine |
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School | School of Medicine |
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Address | 1001 Potrero Ave San Francisco CA 94110
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Phone | 415-476-3257 |
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vCard | Download vCard |
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Biography Peking Union Medical College, Beijing, China | MD degree | 2004 | | Johns Hopkins University School of Medicine | PhD degree | 2010 | Department of Pharmacology and Molecular Sciences | Massachusetts General Hospital | Residency | 2013 | Internal Medicine | University of California, San Francisco | Clinical Fellowship | 2016 | Department of Hematology and Oncology |
American Physician Scientists Association | 2010 | | Travel Award | | 2009 | | Chinese Government Award for Outstanding Students Abroad |
Overview I am fortunate to have joined the world renowned Dr. Bert Vogelstein’s lab for my PhD thesis research on the genomic studies of human cancers. I co-led the first exomic sequencing of human pancreatic cancer, glioblastoma multiforme (GBM), and medulloblastoma, and published three first co-author papers in Science. We made the seminal discovery that IDH1 was highly mutated in GBM, and showed its importance in human cancer for the first time. This has led to the subsequent mechanistic studies and development of targeted therapies in multiple tumor types with IDH1 mutation. My research was rated as one of the Top Ten Breakthrough of Year 2008 by Science.
During my PhD study, my second research focus was on novel cancer therapeutics using anaerobic bacteria Clostridium Novyi-NT to treat solid tumors. I was particularly interested in combining the bacterial therapy with novel immunotherapies to achieve greater response in the cancer bearing mice. I have also contributed to the preclinical safety studies and the launch of the phase I clinical trial using Clostridium Novyi-NT to treat patients with advanced solid tumors.
At UCSF, I continued my translational research in Dr. Andrei Goga's lab. I worked on identification of therapeutic biomarker and development of targeted therapy using breast cancer patient derived xenograft mouse model. We have some very exciting discovery that will be translated into human clinical trial. During my hematology oncology fellowship, I have also developed particular interest in clinical research in GI oncology under the co-mentorship of Drs. Alan Venook and Pamela Munster. This has framed my long term career goal in designing clinical trials and ultimately make an impact on the lives of cancer patients.
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New protein kinase inhibitors in breast cancer: afatinib and neratinib. Expert Opin Pharmacother. 2014 Jun; 15(9):1277-88.
Zhang X, Munster PN. PMID: 24787047.
View in: PubMed Mentions: 14 Fields: Translation: HumansAnimals
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Somatic mutations in the chromatin remodeling gene ARID1A occur in several tumor types. Hum Mutat. 2012 Jan; 33(1):100-3.
Jones S, Li M, Parsons DW, Zhang X, Wesseling J, Kristel P, Schmidt MK, Markowitz S, Yan H, Bigner D, Hruban RH, Eshleman JR, Iacobuzio-Donahue CA, Goggins M, Maitra A, Malek SN, Powell S, Vogelstein B, Kinzler KW, Velculescu VE, Papadopoulos N. PMID: 22009941.
View in: PubMed Mentions: 107 Fields: Translation: HumansCells
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Inactivating mutations of the chromatin remodeling gene ARID2 in hepatocellular carcinoma. Nat Genet. 2011 Aug 07; 43(9):828-9.
Li M, Zhao H, Zhang X, Wood LD, Anders RA, Choti MA, Pawlik TM, Daniel HD, Kannangai R, Offerhaus GJ, Velculescu VE, Wang L, Zhou S, Vogelstein B, Hruban RH, Papadopoulos N, Cai J, Torbenson MS, Kinzler KW. PMID: 21822264.
View in: PubMed Mentions: 178 Fields: Translation: HumansCells
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Sequence analysis of 515 kinase genes in chronic lymphocytic leukemia. Leukemia. 2011 Dec; 25(12):1908-10.
Zhang X, Reis M, Khoriaty R, Li Y, Ouillette P, Samayoa J, Carter H, Karchin R, Li M, Diaz LA, Velculescu VE, Papadopoulos N, Kinzler KW, Vogelstein B, Malek SN. PMID: 21701494.
View in: PubMed Mentions: 10 Fields: Translation: Humans
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The genetic landscape of the childhood cancer medulloblastoma. Science. 2011 Jan 28; 331(6016):435-9.
Parsons DW, Li M, Zhang X, Jones S, Leary RJ, Lin JC, Boca SM, Carter H, Samayoa J, Bettegowda C, Gallia GL, Jallo GI, Binder ZA, Nikolsky Y, Hartigan J, Smith DR, Gerhard DS, Fults DW, VandenBerg S, Berger MS, Marie SK, Shinjo SM, Clara C, Phillips PC, Minturn JE, Biegel JA, Judkins AR, Resnick AC, Storm PB, Curran T, He Y, Rasheed BA, Friedman HS, Keir ST, McLendon R, Northcott PA, Taylor MD, Burger PC, Riggins GJ, Karchin R, Parmigiani G, Bigner DD, Yan H, Papadopoulos N, Vogelstein B, Kinzler KW, Velculescu VE. PMID: 21163964.
View in: PubMed Mentions: 357 Fields: Translation: HumansCells
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SMAD4 gene mutations are associated with poor prognosis in pancreatic cancer. Clin Cancer Res. 2009 Jul 15; 15(14):4674-9.
Blackford A, Serrano OK, Wolfgang CL, Parmigiani G, Jones S, Zhang X, Parsons DW, Lin JC, Leary RJ, Eshleman JR, Goggins M, Jaffee EM, Iacobuzio-Donahue CA, Maitra A, Cameron JL, Olino K, Schulick R, Winter J, Herman JM, Laheru D, Klein AP, Vogelstein B, Kinzler KW, Velculescu VE, Hruban RH. PMID: 19584151.
View in: PubMed Mentions: 133 Fields: Translation: Humans
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Genetic mutations associated with cigarette smoking in pancreatic cancer. Cancer Res. 2009 Apr 15; 69(8):3681-8.
Blackford A, Parmigiani G, Kensler TW, Wolfgang C, Jones S, Zhang X, Parsons DW, Lin JC, Leary RJ, Eshleman JR, Goggins M, Jaffee EM, Iacobuzio-Donahue CA, Maitra A, Klein A, Cameron JL, Olino K, Schulick R, Winter J, Vogelstein B, Velculescu VE, Kinzler KW, Hruban RH. PMID: 19351817.
View in: PubMed Mentions: 36 Fields: Translation: Humans
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Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene. Science. 2009 Apr 10; 324(5924):217.
Jones S, Hruban RH, Kamiyama M, Borges M, Zhang X, Parsons DW, Lin JC, Palmisano E, Brune K, Jaffee EM, Iacobuzio-Donahue CA, Maitra A, Parmigiani G, Kern SE, Velculescu VE, Kinzler KW, Vogelstein B, Eshleman JR, Goggins M, Klein AP. PMID: 19264984.
View in: PubMed Mentions: 303 Fields: Translation: Humans
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An integrated genomic analysis of human glioblastoma multiforme. Science. 2008 Sep 26; 321(5897):1807-12.
Parsons DW, Jones S, Zhang X, Lin JC, Leary RJ, Angenendt P, Mankoo P, Carter H, Siu IM, Gallia GL, Olivi A, McLendon R, Rasheed BA, Keir S, Nikolskaya T, Nikolsky Y, Busam DA, Tekleab H, Diaz LA, Hartigan J, Smith DR, Strausberg RL, Marie SK, Shinjo SM, Yan H, Riggins GJ, Bigner DD, Karchin R, Papadopoulos N, Parmigiani G, Vogelstein B, Velculescu VE, Kinzler KW. PMID: 18772396.
View in: PubMed Mentions: 2139 Fields: Translation: HumansCells
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Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science. 2008 Sep 26; 321(5897):1801-6.
Jones S, Zhang X, Parsons DW, Lin JC, Leary RJ, Angenendt P, Mankoo P, Carter H, Kamiyama H, Jimeno A, Hong SM, Fu B, Lin MT, Calhoun ES, Kamiyama M, Walter K, Nikolskaya T, Nikolsky Y, Hartigan J, Smith DR, Hidalgo M, Leach SD, Klein AP, Jaffee EM, Goggins M, Maitra A, Iacobuzio-Donahue C, Eshleman JR, Kern SE, Hruban RH, Karchin R, Papadopoulos N, Parmigiani G, Vogelstein B, Velculescu VE, Kinzler KW. PMID: 18772397.
View in: PubMed Mentions: 1577 Fields: Translation: HumansCells
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Imaging of musculoskeletal bacterial infections by [124I]FIAU-PET/CT. PLoS One. 2007 Oct 10; 2(10):e1007.
Diaz LA, Foss CA, Thornton K, Nimmagadda S, Endres CJ, Uzuner O, Seyler TM, Ulrich SD, Conway J, Bettegowda C, Agrawal N, Cheong I, Zhang X, Ladenson PW, Vogelstein BN, Mont MA, Zhou S, Kinzler KW, Vogelstein B, Pomper MG. PMID: 17925855.
View in: PubMed Mentions: 32 Fields: Translation: HumansCells
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A multidimensional analysis of genes mutated in breast and colorectal cancers. Genome Res. 2007 Sep; 17(9):1304-18.
Lin J, Gan CM, Zhang X, Jones S, Sjöblom T, Wood LD, Parsons DW, Papadopoulos N, Kinzler KW, Vogelstein B, Parmigiani G, Velculescu VE. PMID: 17693572.
View in: PubMed Mentions: 59 Fields: Translation: HumansCells
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Development and validation of a liquid chromatography/tandem mass spectrometry method for the determination of DMXAA in human and mouse plasma. J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Jun 01; 852(1-2):217-22.
Zhang X, Zhao M, Rudek MA, He P, Vogelstein B. PMID: 17307035.
View in: PubMed Mentions: Fields: Translation: HumansAnimals
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The genome and transcriptomes of the anti-tumor agent Clostridium novyi-NT. Nat Biotechnol. 2006 Dec; 24(12):1573-80.
Bettegowda C, Huang X, Lin J, Cheong I, Kohli M, Szabo SA, Zhang X, Diaz LA, Velculescu VE, Parmigiani G, Kinzler KW, Vogelstein B, Zhou S. PMID: 17115055.
View in: PubMed Mentions: 44 Fields: Translation: HumansAnimalsCells
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Pharmacologic and toxicologic evaluation of C. novyi-NT spores. Toxicol Sci. 2005 Dec; 88(2):562-75.
Diaz LA, Cheong I, Foss CA, Zhang X, Peters BA, Agrawal N, Bettegowda C, Karim B, Liu G, Khan K, Huang X, Kohli M, Dang LH, Hwang P, Vogelstein A, Garrett-Mayer E, Kobrin B, Pomper M, Zhou S, Kinzler KW, Vogelstein B, Huso DL. PMID: 16162850.
View in: PubMed Mentions: 23 Fields: Translation: AnimalsCells
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Year | Publications |
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2005 | 1 | 2006 | 1 | 2007 | 3 | 2008 | 2 | 2009 | 3 | 2010 | 1 | 2011 | 3 | 2014 | 1 |
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