Jennifer Lavail, PhD
|School||UCSF School of Medicine|
Our lab investigates how Herpes simplex virus invade the central nervous system, using murine trigeminal ganglion cells and retinal ganglion cell as models for the study of herpes virus infections in humans. We use both in vivo and in vitro approaches.
Currently the lab is focused on three particular problems:
1. How newly synthesized virus spreads within axons to the next neurons;
2. Development of an in vitro model of axonal transport and encephalitic spread;
3. Development of a mutant HSV strain that can act as a native vaccine to block recurrent corneal keratitis or encephalis.
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