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    Jennifer Lavail, PhD

    TitleProfessor
    SchoolUCSF School of Medicine
    DepartmentAnatomy
    Address513 Parnassus, HSW
    Phone415-476-1694

       Overview 
       Overview
      Our lab investigates how Herpes simplex virus invade the central nervous system, using murine trigeminal ganglion cells and retinal ganglion cell as models for the study of herpes virus infections in humans. We use both in vivo and in vitro approaches.

      Currently the lab is focused on three particular problems:

      1. How newly synthesized virus spreads within axons to the next neurons;
      2. Development of an in vitro model of axonal transport and encephalitic spread;
      3. Development of a mutant HSV strain that can act as a native vaccine to block recurrent corneal keratitis or encephalis.


       Bibliographic 
       Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Draper JM, Huang G, Stephenson GS, Bertke AS, Cortez DA, Lavail JH. Delivery of herpes simplex virus to retinal ganglion cell axon is dependent on viral protein us9. Invest Ophthalmol Vis Sci. 2013; 54(2):962-7.
        View in: PubMed
      2. LaVail JH, Tauscher AN, Sucher A, Harrabi O, Brandimarti R. Viral regulation of the long distance axonal transport of herpes simplex virus nucleocapsid. Neuroscience. 2007 May 25; 146(3):974-85.
        View in: PubMed
      3. Duffy C, Lavail JH, Tauscher AN, Wills EG, Blaho JA, Baines JD. Characterization of a UL49-null mutant: VP22 of herpes simplex virus type 1 facilitates viral spread in cultured cells and the mouse cornea. J Virol. 2006 Sep; 80(17):8664-75.
        View in: PubMed
      4. LaVail JH, Tauscher AN, Hicks JW, Harrabi O, Melroe GT, Knipe DM. Genetic and molecular in vivo analysis of herpes simplex virus assembly in murine visual system neurons. J Virol. 2005 Sep; 79(17):11142-50.
        View in: PubMed
      5. Harrabi O, Tauscher AN, LaVail JH. Temporal expression of herpes simplex virus type 1 mRNA in murine retina. Curr Eye Res. 2004 Aug-Sep; 29(2-3):191-4.
        View in: PubMed
      6. Sidhu SS, Mengistab AT, Tauscher AN, LaVail J, Basbaum C. The microvesicle as a vehicle for EMMPRIN in tumor-stromal interactions. Oncogene. 2004 Jan 29; 23(4):956-63.
        View in: PubMed
      7. Whitehead JL, Ohara PT, Tauscher AN, LaVail JH. A procedure to deliver herpes simplex virus to the murine trigeminal ganglion. Brain Res Brain Res Protoc. 2003 Aug; 12(1):60-6.
        View in: PubMed
      8. LaVail JH, Tauscher AN, Aghaian E, Harrabi O, Sidhu SS. Axonal transport and sorting of herpes simplex virus components in a mature mouse visual system. J Virol. 2003 Jun; 77(11):6117-26.
        View in: PubMed
      9. Ohara PT, Tauscher AN, LaVail JH. Two paths for dissemination of Herpes simplex virus from infected trigeminal ganglion to the murine cornea. Brain Res. 2001 Apr 27; 899(1-2):260-3.
        View in: PubMed
      10. Bearer EL, Breakefield XO, Schuback D, Reese TS, LaVail JH. Retrograde axonal transport of herpes simplex virus: evidence for a single mechanism and a role for tegument. Proc Natl Acad Sci U S A. 2000 Jul 5; 97(14):8146-50.
        View in: PubMed
      11. Ohara PT, Chin MS, LaVail JH. The spread of herpes simplex virus type 1 from trigeminal neurons to the murine cornea: an immunoelectron microscopy study. J Virol. 2000 May; 74(10):4776-86.
        View in: PubMed
      12. Bearer EL, Schlief ML, Breakefield XO, Schuback DE, Reese TS, LaVail JH. Squid axoplasm supports the retrograde axonal transport of herpes simplex virus. Biol Bull. 1999 Oct; 197(2):257-8.
        View in: PubMed
      13. Garner JA, LaVail JH. Differential anterograde transport of HSV type 1 viral strains in the murine optic pathway. J Neurovirol. 1999 Apr; 5(2):140-50.
        View in: PubMed
      14. LaVail JH, Topp KS, Giblin PA, Garner JA. Factors that contribute to the transneuronal spread of herpes simplex virus. J Neurosci Res. 1997 Aug 15; 49(4):485-96.
        View in: PubMed
      15. Topp KS, Rothman AL, Lavail JH. Herpes virus infection of RPE and MDCK cells: polarity of infection. Exp Eye Res. 1997 Mar; 64(3):343-54.
        View in: PubMed
      16. Grimes ML, Zhou J, Beattie EC, Yuen EC, Hall DE, Valletta JS, Topp KS, LaVail JH, Bunnett NW, Mobley WC. Endocytosis of activated TrkA: evidence that nerve growth factor induces formation of signaling endosomes. J Neurosci. 1996 Dec 15; 16(24):7950-64.
        View in: PubMed
      17. Topp KS, Bisla K, Saks ND, Lavail JH. Centripetal transport of herpes simplex virus in human retinal pigment epithelial cells in vitro. Neuroscience. 1996 Apr; 71(4):1133-44.
        View in: PubMed
      18. Kornhauser JM, Leonard MW, Yamamoto M, LaVail JH, Mayo KE, Engel JD. Temporal and spatial changes in GATA transcription factor expression are coincident with development of the chicken optic tectum. Brain Res Mol Brain Res. 1994 Apr; 23(1-2):100-10.
        View in: PubMed
      19. Topp KS, Meade LB, LaVail JH. Microtubule polarity in the peripheral processes of trigeminal ganglion cells: relevance for the retrograde transport of herpes simplex virus. J Neurosci. 1994 Jan; 14(1):318-25.
        View in: PubMed
      20. LaVail JH, Carter SR, Topp KS. The retrograde tracer Fluoro-Gold interferes with the infectivity of herpes simplex virus. Brain Res. 1993 Oct 15; 625(1):57-62.
        View in: PubMed
      21. LaVail JH, Johnson WE, Spencer LC. Immunohistochemical identification of trigeminal ganglion neurons that innervate the mouse cornea: relevance to intercellular spread of herpes simplex virus. J Comp Neurol. 1993 Jan 1; 327(1):133-40.
        View in: PubMed
      22. Carter SR, Pereira L, Paz P, LaVail JH. A quantitative assay of retrograde transported HSV in the trigeminal ganglion. Invest Ophthalmol Vis Sci. 1992 May; 33(6):1934-9.
        View in: PubMed
      23. Margolis TP, Dawson CR, LaVail JH. Herpes simplex viral infection of the mouse trigeminal ganglion. Immunohistochemical analysis of cell populations. Invest Ophthalmol Vis Sci. 1992 Feb; 33(2):259-67.
        View in: PubMed
      24. Engel JD, Beug H, LaVail JH, Zenke MW, Mayo K, Leonard MW, Foley KP, Yang Z, Kornhauser JM, Ko LJ, et al. cis and trans regulation of tissue-specific transcription. J Cell Sci Suppl. 1992; 16:21-31.
        View in: PubMed
      25. LaVail JH, Meade LB, Dawson CR. Ultrastructural immunocytochemical localization of herpes simplex virus (type 1) in trigeminal ganglion neurons. Curr Eye Res. 1991; 10 Suppl:23-9.
        View in: PubMed
      26. LaVail JH, Zhan J, Margolis TP. HSV (type 1) infection of the trigeminal complex. Brain Res. 1990 Apr 30; 514(2):181-8.
        View in: PubMed
      27. Margolis TP, LaVail JH, Setzer PY, Dawson CR. Selective spread of herpes simplex virus in the central nervous system after ocular inoculation. J Virol. 1989 Nov; 63(11):4756-61.
        View in: PubMed
      28. LaVail JH, Irons KP. Abnormal neuromuscular junctions in the lateral rectus muscle of wobbler mice. Brain Res. 1988 Oct 25; 463(1):78-89.
        View in: PubMed
      29. LaVail JH, Koo EH, Dekker NP. Motoneuron loss in the abducens nucleus of wobbler mice. Brain Res. 1987 Feb 24; 404(1-2):127-32.
        View in: PubMed
      30. Margolis T, Togni B, LaVail J, Dawson CR. Identifying HSV infected neurons after ocular inoculation. Curr Eye Res. 1987 Jan; 6(1):119-26.
        View in: PubMed
      31. LaVail JH. Localization of axonally transported [125I]wheat germ agglutinin in rat abducens motoneuron axons and terminals after intracisternal injection. Neurosci Lett. 1985 Nov 11; 61(3):291-8.
        View in: PubMed
      32. Margolis TP, LaVail JH. Further evidence in support of the selective uptake and anterograde transport of [125I]wheat germ agglutinin by chick retinal ganglion cells. Brain Res. 1984 Dec 17; 324(1):21-7.
        View in: PubMed
      33. LaVail JH. Anterograde axonal transport of [125I]wheat germ agglutinin by motor neurons innervating the rat lateral rectus muscle. Neurosci Lett. 1984 Sep 7; 50(1-3):295-300.
        View in: PubMed
      34. LaVail JH, Sugino IK. Localization of axonally transported label in chick retinal ganglion cell axons after intravitreal injections of wheat germ agglutinin conjugated to horseradish peroxidase. Brain Res. 1984 Jun 18; 304(1):59-69.
        View in: PubMed
      35. Eisenfeld AJ, LaVail MM, LaVail JH. Assessment of possible transneuronal changes in the retina of rats with inherited retinal dystrophy: cell size, number, synapses, and axonal transport by retinal ganglion cells. J Comp Neurol. 1984 Feb 10; 223(1):22-34.
        View in: PubMed
      36. LaVail JH, Sugino IK, McDonald DM. Localization of axonally transported 125I-wheat germ agglutinin beneath the plasma membrane of chick retinal ganglion cells. J Cell Biol. 1983 Feb; 96(2):373-81.
        View in: PubMed
      37. Margolis TP, LaVail JH. Rate of anterograde axonal transport of [125I]wheat germ agglutinin from retina to optic tectum in the chick. Brain Res. 1981 Dec 14; 229(1):218-23.
        View in: PubMed
      38. Kistler HB, LaVail JH. Penetration of horseradish peroxidase into the optic nerve after vitreal or vascular injections in the developing chick. Invest Ophthalmol Vis Sci. 1981 Jun; 20(6):705-16.
        View in: PubMed
      39. Lavail JH, Rapisardi S, Sugino IK. Evidence against the smooth endoplasmic reticulum as a continuous channel for the retrograde axonal transport of horseradish peroxidase. Brain Res. 1980 Jun 2; 191(1):3-20.
        View in: PubMed
      40. Kouvelas ED, Luckenbill-Edds L, LaVail JH, Greene LA. Effects of eye removal on receptors of alpha-bungarotoxin in the optic lobes of chick brain. Neurosci Lett. 1979 Jan; 11(1):99-102.
        View in: PubMed
      41. LaVail JH, Nixon RA, Sidman RL. Genetic control of retinal ganglion cell projections. J Comp Neurol. 1978 Dec 1; 182(3):399-421.
        View in: PubMed
      42. Kneisley LW, Biber MP, LaVail JH. A study of the origin of brain stem projections to monkey spinal cord using the retrograde transport method. Exp Neurol. 1978 May 15; 60(1):116-39.
        View in: PubMed
      43. Biber MP, Kneisley LW, LaVail JH. Cortical neurons projecting to the cervical and lumbar enlargements of the spinal cord in young and adult rhesus monkeys. Exp Neurol. 1978 May 1; 59(3):492-508.
        View in: PubMed
      44. Divac I, Lavail JH, Rakic P, Winston KR. Heterogeneous afferents to the inferior parietal lobule of the rhesus monkey revealed by the retrograde transport method. Brain Res. 1977 Mar 11; 123(2):197-207.
        View in: PubMed
      45. Halperin JJ, LaVail JH. A study of the dynamics of retrograde transport and accumulation of horseradish peroxidase in injured neurons. Brain Res. 1975 Dec 19; 100(2):253-69.
        View in: PubMed
      46. Nowakowski RS, LaVail J, Rakic P. The correlation of the time of origin of neurons with their axonal projection: the combined use of [3H]thymidine autoradiography and horseradish peroxidase histochemistry. Brain Res. 1975 Dec 5; 99(2):343-8.
        View in: PubMed
      47. LaVail JH. The retrograde transport method. Fed Proc. 1975 Jun; 34(7):1618-24.
        View in: PubMed
      48. LaVail MM, LaVail JH. Retrograde intraaxonal transport of horseradish peroxidase in retinal ganglion cells of the chick. Brain Res. 1975 Feb 28; 85(2):273-80.
        View in: PubMed
      49. LaVail JH, LaVail MM. The retrograde intraaxonal transport of horseradish peroxidase in the chick visual system: a light and electron microscopic study. J Comp Neurol. 1974 Oct 1; 157(3):303-57.
        View in: PubMed
      50. LaVail JH, Winston KR, Tish A. A method based on retrograde intraaxonal transport of protein for identification of cell bodies of origin of axons terminating within the CNS. Brain Res. 1973 Aug 30; 58(2):470-7.
        View in: PubMed
      51. LaVail JH, Wolf MK. Postnatal development of the mouse dentate gyrus in organotypic cultures of the hippocampal formation. Am J Anat. 1973 May; 137(1):47-65.
        View in: PubMed
      52. LaVail JH, LaVail MM. Retrograde axonal transport in the central nervous system. Science. 1972 Jun 30; 176(4042):1416-7.
        View in: PubMed
      53. LaVail JH, Cowan WM. The development of the chick optic tectum. I. Normal morphology and cytoarchitectonic development. Brain Res. 1971 May 21; 28(3):391-419.
        View in: PubMed
      54. LaVail JH, Cowan WM. The development of the chick optic tectum. II. Autoradiographic studies. Brain Res. 1971 May 21; 28(3):421-41.
        View in: PubMed
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