Casper Hoogenraad, PhD

Title(s)Professor, Biochemistry and Biophysics
SchoolSchool of Medicine
Address555 Mission Bay Blvd South
San Francisco CA 94158
Phone--
ORCID ORCID Icon0000-0002-2666-0758 Additional info
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    Collapse Biography 
    Collapse Education and Training
    Utrecht University, Utrecht, NLMScMolecular Biology
    Erasmus University, Rotterdam, NLPhDCell Biology
    Massachusetts Institute of Technology, Cambridge, MApostdocNeurobiology
    Collapse Awards and Honors
    201610th International Brain Research Organization (IBRO) / Kemali Prize
    2015Member of the European Molecular Biology Organization (EMBO)
    2015Member of Young Academy of Europe (YAE)
    2014Member of FENS-Kavli Network of Excellence (FKNE)
    2011The Young Academy of the Royal Netherlands Academy for Arts and Science

    Collapse Overview 
    Collapse Overview
    Casper Hoogenraad serves as Vice President, Head of Neuroscience at Genentech Research and Early Development in South San Francisco, California. In this role, he is head of the Neuroscience Department, responsible for research and drug discovery activities in Neuroscience and oversees Genentech’s Neuroscience disease pipeline programs. He is Adjunct Professor in Department of Biochemistry and Biophysics at University of California San Francisco (UCSF).

    Prior to joining Genentech, he was full Professor of Molecular Neuroscience and served as Chair of the Cell Biology, Neurobiology and Biophysics Division at Utrecht University, The Netherlands. Casper received his Bachelor of Science in Biochemistry and Master of Science in Molecular Biology from Utrecht University, and his doctorate in Cell Biology from the Erasmus University Rotterdam. Casper was a postdoctoral fellow at the Massachusetts Institute of Technology (MIT) in Cambridge, Massachusetts and joined the faculty of the Erasmus Medical Center Rotterdam as an Associate Professor in the Department of Neuroscience.

    Casper continues his basic research as a Senior Fellow at Genentech to study the molecular and cellular mechanisms that regulate the development and function of the brain and aims to translate these findings into potential therapies for neurodegenerative disorders such as Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis. Throughout his career, he discovered new molecular mechanisms and cell biological processes that control cytoskeleton remodeling and cargo trafficking. Work from his lab has characterized in detail the cytoskeleton and transport events required to 'build' and 'wire' neurons, including the early developmental stages of axon formation and neuronal polarization, assembly of the axon initial segment, dendrite outgrowth and spine plasticity. He has also contributed to the development of new molecular methods and imaging tools to study intracellular dynamics in living cells.

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Inducible manipulation of motor-cargo interaction using engineered kinesin motors. J Cell Sci. 2021 Aug 01; 134(15). Hummel JJA, Hoogenraad CC. PMID: 34342354.
      View in: PubMed   Mentions:    Fields:    
    2. ER - lysosome contacts at a pre-axonal region regulate axonal lysosome availability. Nat Commun. 2021 07 23; 12(1):4493. Özkan N, Koppers M, van Soest I, van Harten A, Jurriens D, Liv N, Klumperman J, Kapitein LC, Hoogenraad CC, Farías GG. PMID: 34301956.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    3. Specific KIF1A-adaptor interactions control selective cargo recognition. J Cell Biol. 2021 Oct 04; 220(10). Hummel JJA, Hoogenraad CC. PMID: 34287616.
      View in: PubMed   Mentions:    Fields:    
    4. WDR47 protects neuronal microtubule minus ends from katanin-mediated severing. Cell Rep. 2021 Jul 13; 36(2):109371. Buijs RR, Hummel JJA, Burute M, Pan X, Cao Y, Stucchi R, Altelaar M, Akhmanova A, Kapitein LC, Hoogenraad CC. PMID: 34260930.
      View in: PubMed   Mentions:    Fields:    
    5. Inducible manipulation of motor-cargo interaction using engineered kinesin motors. J Cell Sci. 2021 Jul 08. Hummel JJA, Hoogenraad CC. PMID: 34237142.
      View in: PubMed   Mentions:    Fields:    
    6. Multiple layers of spatial regulation coordinate axonal cargo transport. Curr Opin Neurobiol. 2021 08; 69:241-246. Zahavi EE, Hoogenraad CC. PMID: 34171618.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    7. Combined kinesin-1 and kinesin-3 activity drives axonal trafficking of TrkB receptors in Rab6 carriers. Dev Cell. 2021 May 17; 56(10):1552-1554. Zahavi EE, Hummel JJA, Han Y, Bar C, Stucchi R, Altelaar M, Hoogenraad CC. PMID: 34004153.
      View in: PubMed   Mentions: 1     Fields:    
    8. Centrosome-mediated microtubule remodeling during axon formation in human iPSC-derived neurons. EMBO J. 2021 May 17; 40(10):e106798. Lindhout FW, Portegies S, Kooistra R, Herstel LJ, Stucchi R, Hummel JJA, Scheefhals N, Katrukha EA, Altelaar M, MacGillavry HD, Wierenga CJ, Hoogenraad CC. PMID: 33835529.
      View in: PubMed   Mentions: 2     Fields:    
    9. Combined kinesin-1 and kinesin-3 activity drives axonal trafficking of TrkB receptors in Rab6 carriers. Dev Cell. 2021 02 22; 56(4):494-508.e7. Zahavi EE, Hummel JJA, Han Y, Bar C, Stucchi R, Altelaar M, Hoogenraad CC. PMID: 33571451.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    10. The mechanism of kinesin inhibition by kinesin-binding protein. Elife. 2020 11 30; 9. Atherton J, Hummel JJ, Olieric N, Locke J, Peña A, Rosenfeld SS, Steinmetz MO, Hoogenraad CC, Moores CA. PMID: 33252036.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    11. Quantitative mapping of transcriptome and proteome dynamics during polarization of human iPSC-derived neurons. Elife. 2020 09 17; 9. Lindhout FW, Kooistra R, Portegies S, Herstel LJ, Stucchi R, Snoek BL, Altelaar AM, MacGillavry HD, Wierenga CJ, Hoogenraad CC. PMID: 32940601.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    12. Temporal Quantitative Proteomics of mGluR-induced Protein Translation and Phosphorylation in Neurons. Mol Cell Proteomics. 2020 12; 19(12):1952-1968. van Gelder CAGH, Penning R, Veth TS, Catsburg LAE, Hoogenraad CC, MacGillavry HD, Altelaar M. PMID: 32912969.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    13. Deciphering the Proteome Dynamics during Development of Neurons Derived from Induced Pluripotent Stem Cells. J Proteome Res. 2020 06 05; 19(6):2391-2403. Varderidou-Minasian S, Verheijen BM, Schätzle P, Hoogenraad CC, Pasterkamp RJ, Altelaar M. PMID: 32357013.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    14. Interleukin-17: A Social Cytokine. Cell. 2020 04 30; 181(3):517-519. Hoogenraad CC, Riol-Blanco L. PMID: 32359435.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    15. Cortical anchoring of the microtubule cytoskeleton is essential for neuron polarity. Elife. 2020 04 15; 9. He L, Kooistra R, Das R, Oudejans E, van Leen E, Ziegler J, Portegies S, de Haan B, van Regteren Altena A, Stucchi R, Altelaar AM, Wieser S, Krieg M, Hoogenraad CC, Harterink M. PMID: 32293562.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    16. Tropomyosin Tpm3.1 Is Required to Maintain the Structure and Function of the Axon Initial Segment. iScience. 2020 May 22; 23(5):101053. Abouelezz A, Stefen H, Segerstråle M, Micinski D, Minkeviciene R, Lahti L, Hardeman EC, Gunning PW, Hoogenraad CC, Taira T, Fath T, Hotulainen P. PMID: 32344377.
      View in: PubMed   Mentions:
    17. Publisher Correction: Global site-specific neddylation profiling reveals that NEDDylated cofilin regulates actin dynamics. Nat Struct Mol Biol. 2020 Apr; 27(4):400. Vogl AM, Phu L, Becerra R, Giusti SA, Verschueren E, Hinkle TB, Bordenave MD, Adrian M, Heidersbach A, Yankilevich P, Stefani FD, Wurst W, Hoogenraad CC, Kirkpatrick DS, Refojo D, Sheng M. PMID: 32103165.
      View in: PubMed   Mentions:    Fields:    
    18. Loss of BICD2 in muscle drives motor neuron loss in a developmental form of spinal muscular atrophy. Acta Neuropathol Commun. 2020 03 17; 8(1):34. Rossor AM, Sleigh JN, Groves M, Muntoni F, Reilly MM, Hoogenraad CC, Schiavo G. PMID: 32183910.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    19. Microtubule Minus-End Binding Protein CAMSAP2 and Kinesin-14 Motor KIFC3 Control Dendritic Microtubule Organization. Curr Biol. 2020 03 09; 30(5):899-908.e6. Cao Y, Lipka J, Stucchi R, Burute M, Pan X, Portegies S, Tas R, Willems J, Will L, MacGillavry H, Altelaar M, Kapitein LC, Harterink M, Hoogenraad CC. PMID: 32084403.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    20. Global site-specific neddylation profiling reveals that NEDDylated cofilin regulates actin dynamics. Nat Struct Mol Biol. 2020 02; 27(2):210-220. Vogl AM, Phu L, Becerra R, Giusti SA, Verschueren E, Hinkle TB, Bordenave MD, Adrian M, Heidersbach A, Yankilevich P, Stefani FD, Wurst W, Hoogenraad CC, Kirkpatrick DS, Refojo D, Sheng M. PMID: 32015554.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    21. Arginine π-stacking drives binding to fibrils of the Alzheimer protein Tau. Nat Commun. 2020 Jan 29; 11(1):571. Ferrari L, Stucchi R, Konstantoulea K, van de Kamp G, Kos R, Geerts WJC, van Bezouwen LS, Förster FG, Altelaar M, Hoogenraad CC, Rüdiger SGD. PMID: 31996674.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    22. Neuronal Cytoskeleton: Presynaptic Boutons as Hotspots for Activity-Dependent Microtubule Nucleation. Curr Biol. 2019 12 16; 29(24):R1307-R1309. Freal A, Hoogenraad CC. PMID: 31846677.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    23. Glucocorticoid and β-adrenergic regulation of hippocampal dendritic spines. J Neuroendocrinol. 2020 01; 32(1):e12811. Lesuis SL, Timmermans W, Lucassen PJ, Hoogenraad CC, Krugers HJ. PMID: 31715030.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    24. Solving the Mysteries of Dementia: FTD Mutant Tau Impairs Structural Axon Initial Segment Plasticity. Neuron. 2019 11 06; 104(3):429-430. Lipka J, Hoogenraad CC. PMID: 31697915.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    25. Dynein activating adaptor BICD2 controls radial migration of upper-layer cortical neurons in vivo. Acta Neuropathol Commun. 2019 10 26; 7(1):162. Will L, Portegies S, van Schelt J, van Luyk M, Jaarsma D, Hoogenraad CC. PMID: 31655624.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    26. Shank Proteins Couple the Endocytic Zone to the Postsynaptic Density to Control Trafficking and Signaling of Metabotropic Glutamate Receptor 5. Cell Rep. 2019 Oct 08; 29(2):258-269.e8. Scheefhals N, Catsburg LAE, Westerveld ML, Blanpied TA, Hoogenraad CC, MacGillavry HD. PMID: 31597090.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    27. Cytolinker Gas2L1 regulates axon morphology through microtubule-modulated actin stabilization. EMBO Rep. 2019 11 05; 20(11):e47732. van de Willige D, Hummel JJ, Alkemade C, Kahn OI, Au FK, Qi RZ, Dogterom M, Koenderink GH, Hoogenraad CC, Akhmanova A. PMID: 31486213.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    28. Feedback-Driven Assembly of the Axon Initial Segment. Neuron. 2019 10 23; 104(2):305-321.e8. Fréal A, Rai D, Tas RP, Pan X, Katrukha EA, van de Willige D, Stucchi R, Aher A, Yang C, Altelaar AFM, Vocking K, Post JA, Harterink M, Kapitein LC, Akhmanova A, Hoogenraad CC. PMID: 31474508.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    29. VAP-SCRN1 interaction regulates dynamic endoplasmic reticulum remodeling and presynaptic function. EMBO J. 2019 10 15; 38(20):e101345. Lindhout FW, Cao Y, Kevenaar JT, Bodzeta A, Stucchi R, Boumpoutsari MM, Katrukha EA, Altelaar M, MacGillavry HD, Hoogenraad CC. PMID: 31441084.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    30. SynGO: An Evidence-Based, Expert-Curated Knowledge Base for the Synapse. Neuron. 2019 07 17; 103(2):217-234.e4. Koopmans F, van Nierop P, Andres-Alonso M, Byrnes A, Cijsouw T, Coba MP, Cornelisse LN, Farrell RJ, Goldschmidt HL, Howrigan DP, Hussain NK, Imig C, de Jong APH, Jung H, Kohansalnodehi M, Kramarz B, Lipstein N, Lovering RC, MacGillavry H, Mariano V, Mi H, Ninov M, Osumi-Sutherland D, Pielot R, Smalla KH, Tang H, Tashman K, Toonen RFG, Verpelli C, Reig-Viader R, Watanabe K, van Weering J, Achsel T, Ashrafi G, Asi N, Brown TC, De Camilli P, Feuermann M, Foulger RE, Gaudet P, Joglekar A, Kanellopoulos A, Malenka R, Nicoll RA, Pulido C, de Juan-Sanz J, Sheng M, Südhof TC, Tilgner HU, Bagni C, Bayés À, Biederer T, Brose N, Chua JJE, Dieterich DC, Gundelfinger ED, Hoogenraad C, Huganir RL, Jahn R, Kaeser PS, Kim E, Kreutz MR, McPherson PS, Neale BM, O'Connor V, Posthuma D, Ryan TA, Sala C, Feng G, Hyman SE, Thomas PD, Smit AB, Verhage M. PMID: 31171447.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansAnimalsCells
    31. The expanded clinical spectrum of anti-GABABR encephalitis and added value of KCTD16 autoantibodies. Brain. 2019 06 01; 142(6):1631-1643. van Coevorden-Hameete MH, de Bruijn MAAM, de Graaff E, Bastiaansen DAEM, Schreurs MWJ, Demmers JAA, Ramberger M, Hulsenboom ESP, Nagtzaam MMP, Boukhrissi S, Veldink JH, Verschuuren JJGM, Hoogenraad CC, Sillevis Smitt PAE, Titulaer MJ. PMID: 31009048.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    32. Endocannabinoid Signaling Mediates Local Dendritic Coordination between Excitatory and Inhibitory Synapses. Cell Rep. 2019 04 16; 27(3):666-675.e5. Hu HY, Kruijssen DLH, Frias CP, Rózsa B, Hoogenraad CC, Wierenga CJ. PMID: 30995465.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    33. TRIM46 Organizes Microtubule Fasciculation in the Axon Initial Segment. J Neurosci. 2019 06 19; 39(25):4864-4873. Harterink M, Vocking K, Pan X, Soriano Jerez EM, Slenders L, Fréal A, Tas RP, van de Wetering WJ, Timmer K, Motshagen J, van Beuningen SFB, Kapitein LC, Geerts WJC, Post JA, Hoogenraad CC. PMID: 30967428.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    34. Semaphorin4D Induces Inhibitory Synapse Formation by Rapid Stabilization of Presynaptic Boutons via MET Coactivation. J Neurosci. 2019 05 29; 39(22):4221-4237. Frias CP, Liang J, Bresser T, Scheefhals L, van Kesteren M, van Dorland R, Hu HY, Bodzeta A, van Bergen En Henegouwen PMP, Hoogenraad CC, Wierenga CJ. PMID: 30914448.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    35. Wnt Signaling Directs Neuronal Polarity and Axonal Growth. iScience. 2019 Mar 29; 13:318-327. Stanganello E, Zahavi EE, Burute M, Smits J, Jordens I, Maurice MM, Kapitein LC, Hoogenraad CC. PMID: 30878878.
      View in: PubMed   Mentions:
    36. MAP7D2 Localizes to the Proximal Axon and Locally Promotes Kinesin-1-Mediated Cargo Transport into the Axon. Cell Rep. 2019 02 19; 26(8):1988-1999.e6. Pan X, Cao Y, Stucchi R, Hooikaas PJ, Portegies S, Will L, Martin M, Akhmanova A, Harterink M, Hoogenraad CC. PMID: 30784582.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    37. MAP7 family proteins regulate kinesin-1 recruitment and activation. J Cell Biol. 2019 04 01; 218(4):1298-1318. Hooikaas PJ, Martin M, Mühlethaler T, Kuijntjes GJ, Peeters CAE, Katrukha EA, Ferrari L, Stucchi R, Verhagen DGF, van Riel WE, Grigoriev I, Altelaar AFM, Hoogenraad CC, Rüdiger SGD, Steinmetz MO, Kapitein LC, Akhmanova A. PMID: 30770434.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    38. Feedback-Driven Mechanisms between Microtubules and the Endoplasmic Reticulum Instruct Neuronal Polarity. Neuron. 2019 04 03; 102(1):184-201.e8. Farías GG, Fréal A, Tortosa E, Stucchi R, Pan X, Portegies S, Will L, Altelaar M, Hoogenraad CC. PMID: 30772082.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    39. More is not always better: hyperglutamylation leads to neurodegeneration. EMBO J. 2018 12 03; 37(23). Akhmanova A, Hoogenraad CC. PMID: 30470721.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    40. Local microtubule organization promotes cargo transport in C. elegans dendrites. J Cell Sci. 2018 10 22; 131(20). Harterink M, Edwards SL, de Haan B, Yau KW, van den Heuvel S, Kapitein LC, Miller KG, Hoogenraad CC. PMID: 30254025.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    41. Modifying Rap1-signalling by targeting Pde6δ is neuroprotective in models of Alzheimer's disease. Mol Neurodegener. 2018 09 26; 13(1):50. Dumbacher M, Van Dooren T, Princen K, De Witte K, Farinelli M, Lievens S, Tavernier J, Dehaen W, Wera S, Winderickx J, Allasia S, Kilonda A, Spieser S, Marchand A, Chaltin P, Hoogenraad CC, Griffioen G. PMID: 30257685.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    42. Membrane trafficking and cytoskeletal dynamics in neuronal function. Mol Cell Neurosci. 2018 09; 91:1-2. MacGillavry HD, Hoogenraad CC. PMID: 30190013.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    43. Polarity of Neuronal Membrane Traffic Requires Sorting of Kinesin Motor Cargo during Entry into Dendrites by a Microtubule-Associated Septin. Dev Cell. 2018 08 20; 46(4):518-524. Karasmanis EP, Phan CT, Angelis D, Kesisova IA, Hoogenraad CC, McKenney RJ, Spiliotis ET. PMID: 30130532.
      View in: PubMed   Mentions: 2     Fields:    
    44. The HAUS Complex Is a Key Regulator of Non-centrosomal Microtubule Organization during Neuronal Development. Cell Rep. 2018 07 24; 24(4):791-800. Cunha-Ferreira I, Chazeau A, Buijs RR, Stucchi R, Will L, Pan X, Adolfs Y, van der Meer C, Wolthuis JC, Kahn OI, Schätzle P, Altelaar M, Pasterkamp RJ, Kapitein LC, Hoogenraad CC. PMID: 30044976.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    45. Regulation of KIF1A-Driven Dense Core Vesicle Transport: Ca2+/CaM Controls DCV Binding and Liprin-α/TANC2 Recruits DCVs to Postsynaptic Sites. Cell Rep. 2018 07 17; 24(3):685-700. Stucchi R, Plucinska G, Hummel JJA, Zahavi EE, Guerra San Juan I, Klykov O, Scheltema RA, Altelaar AFM, Hoogenraad CC. PMID: 30021165.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    46. APC2 controls dendrite development by promoting microtubule dynamics. Nat Commun. 2018 07 17; 9(1):2773. Kahn OI, Schätzle P, van de Willige D, Tas RP, Lindhout FW, Portegies S, Kapitein LC, Hoogenraad CC. PMID: 30018294.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    47. Polarity of Neuronal Membrane Traffic Requires Sorting of Kinesin Motor Cargo during Entry into Dendrites by a Microtubule-Associated Septin. Dev Cell. 2018 07 16; 46(2):204-218.e7. Karasmanis EP, Phan CT, Angelis D, Kesisova IA, Hoogenraad CC, McKenney RJ, Spiliotis ET. PMID: 30016622.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    48. Activity-Dependent Actin Remodeling at the Base of Dendritic Spines Promotes Microtubule Entry. Curr Biol. 2018 07 09; 28(13):2081-2093.e6. Schätzle P, Esteves da Silva M, Tas RP, Katrukha EA, Hu HY, Wierenga CJ, Kapitein LC, Hoogenraad CC. PMID: 29910073.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    49. Local mechanisms regulating selective cargo entry and long-range trafficking in axons. Curr Opin Neurobiol. 2018 08; 51:23-28. Gumy LF, Hoogenraad CC. PMID: 29510294.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    50. Caldendrin Directly Couples Postsynaptic Calcium Signals to Actin Remodeling in Dendritic Spines. Neuron. 2018 03 07; 97(5):1110-1125.e14. Mikhaylova M, Bär J, van Bommel B, Schätzle P, YuanXiang P, Raman R, Hradsky J, Konietzny A, Loktionov EY, Reddy PP, Lopez-Rojas J, Spilker C, Kobler O, Raza SA, Stork O, Hoogenraad CC, Kreutz MR. PMID: 29478916.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    51. Polarized trafficking: the palmitoylation cycle distributes cytoplasmic proteins to distinct neuronal compartments. Curr Opin Cell Biol. 2018 02; 50:64-71. Tortosa E, Hoogenraad CC. PMID: 29475137.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    52. Differentiation between Oppositely Oriented Microtubules Controls Polarized Neuronal Transport. Neuron. 2017 12 20; 96(6):1264-1271.e5. Tas RP, Chazeau A, Cloin BMC, Lambers MLA, Hoogenraad CC, Kapitein LC. PMID: 29198755.
      View in: PubMed   Mentions: 61     Fields:    Translation:AnimalsCells
    53. Myosin-V Induces Cargo Immobilization and Clustering at the Axon Initial Segment. Front Cell Neurosci. 2017; 11:260. Janssen AFJ, Tas RP, van Bergeijk P, Oost R, Hoogenraad CC, Kapitein LC. PMID: 28894417.
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    54. Solubilization of human cells by the styrene-maleic acid copolymer: Insights from fluorescence microscopy. Biochim Biophys Acta Biomembr. 2017 Nov; 1859(11):2155-2160. Dörr JM, van Coevorden-Hameete MH, Hoogenraad CC, Killian JA. PMID: 28847501.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    55. Antibodies to TRIM46 are associated with paraneoplastic neurological syndromes. Ann Clin Transl Neurol. 2017 09; 4(9):680-686. van Coevorden-Hameete MH, van Beuningen SFB, Perrenoud M, Will LM, Hulsenboom E, Demonet JF, Sabater L, Kros JM, Verschuuren JJGM, Titulaer MJ, de Graaff E, Sillevis Smitt PAE, Hoogenraad CC. PMID: 28904989.
      View in: PubMed   Mentions: 6     Fields:    
    56. Probing the Interplay between Dendritic Spine Morphology and Membrane-Bound Diffusion. Biophys J. 2017 Nov 21; 113(10):2261-2270. Adrian M, Kusters R, Storm C, Hoogenraad CC, Kapitein LC. PMID: 28750887.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    57. Efficient switching of mCherry fluorescence using chemical caging. Proc Natl Acad Sci U S A. 2017 07 03; 114(27):7013-7018. Cloin BMC, De Zitter E, Salas D, Gielen V, Folkers GE, Mikhaylova M, Bergeler M, Krajnik B, Harvey J, Hoogenraad CC, Van Meervelt L, Dedecker P, Kapitein LC. PMID: 28630286.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    58. Dynamic Palmitoylation Targets MAP6 to the Axon to Promote Microtubule Stabilization during Neuronal Polarization. Neuron. 2017 May 17; 94(4):809-825.e7. Tortosa E, Adolfs Y, Fukata M, Pasterkamp RJ, Kapitein LC, Hoogenraad CC. PMID: 28521134.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    59. MAP2 Defines a Pre-axonal Filtering Zone to Regulate KIF1- versus KIF5-Dependent Cargo Transport in Sensory Neurons. Neuron. 2017 Apr 19; 94(2):347-362.e7. Gumy LF, Katrukha EA, Grigoriev I, Jaarsma D, Kapitein LC, Akhmanova A, Hoogenraad CC. PMID: 28426968.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCells
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    131. Off the rails: axonal cargoes on the road to nowhere. EMBO J. 2013 May 15; 32(10):1345-7. Gumy LF, Hoogenraad CC. PMID: 23612610.
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    132. Myosin-V opposes microtubule-based cargo transport and drives directional motility on cortical actin. Curr Biol. 2013 May 06; 23(9):828-34. Kapitein LC, van Bergeijk P, Lipka J, Keijzer N, Wulf PS, Katrukha EA, Akhmanova A, Hoogenraad CC. PMID: 23602478.
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    133. Spatio-temporal analysis of molecular determinants of neuronal degeneration in the aging mouse cerebellum. Mol Cell Proteomics. 2013 May; 12(5):1350-62. de Graaf EL, Vermeij WP, de Waard MC, Rijksen Y, van der Pluijm I, Hoogenraad CC, Hoeijmakers JH, Altelaar AF, Heck AJ. PMID: 23399551.
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    134. TRAK/Milton motor-adaptor proteins steer mitochondrial trafficking to axons and dendrites. Neuron. 2013 Feb 06; 77(3):485-502. van Spronsen M, Mikhaylova M, Lipka J, Schlager MA, van den Heuvel DJ, Kuijpers M, Wulf PS, Keijzer N, Demmers J, Kapitein LC, Jaarsma D, Gerritsen HC, Akhmanova A, Hoogenraad CC. PMID: 23395375.
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    135. Structural basis of tubulin tyrosination by tubulin tyrosine ligase. J Cell Biol. 2013 Feb 04; 200(3):259-70. Prota AE, Magiera MM, Kuijpers M, Bargsten K, Frey D, Wieser M, Jaussi R, Hoogenraad CC, Kammerer RA, Janke C, Steinmetz MO. PMID: 23358242.
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    137. BICD2, dynactin, and LIS1 cooperate in regulating dynein recruitment to cellular structures. Mol Biol Cell. 2012 Nov; 23(21):4226-41. Splinter D, Razafsky DS, Schlager MA, Serra-Marques A, Grigoriev I, Demmers J, Keijzer N, Jiang K, Poser I, Hyman AA, Hoogenraad CC, King SJ, Akhmanova A. PMID: 22956769.
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    138. Identification of delta/notch-like epidermal growth factor-related receptor as the Tr antigen in paraneoplastic cerebellar degeneration. Ann Neurol. 2012 Jun; 71(6):815-24. de Graaff E, Maat P, Hulsenboom E, van den Berg R, van den Bent M, Demmers J, Lugtenburg PJ, Hoogenraad CC, Sillevis Smitt P. PMID: 22447725.
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    139. Molecular motors in cargo trafficking and synapse assembly. Adv Exp Med Biol. 2012; 970:173-96. van den Berg R, Hoogenraad CC. PMID: 22351056.
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    140. Differential expression of liprin-α family proteins in the brain suggests functional diversification. J Comp Neurol. 2011 Oct 15; 519(15):3040-60. Spangler SA, Jaarsma D, De Graaff E, Wulf PS, Akhmanova A, Hoogenraad CC. PMID: 21618222.
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    141. Combined β-adrenergic and corticosteroid receptor activation regulates AMPA receptor function in hippocampal neurons. J Psychopharmacol. 2012 Apr; 26(4):516-24. Zhou M, Hoogenraad CC, Joëls M, Krugers HJ. PMID: 21965192.
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    142. Maintenance of dendritic spine morphology by partitioning-defective 1b through regulation of microtubule growth. J Neurosci. 2011 Aug 24; 31(34):12094-103. Hayashi K, Suzuki A, Hirai S, Kurihara Y, Hoogenraad CC, Ohno S. PMID: 21865452.
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    143. Liprin-mediated large signaling complex organization revealed by the liprin-α/CASK and liprin-α/liprin-β complex structures. Mol Cell. 2011 Aug 19; 43(4):586-98. Wei Z, Zheng S, Spangler SA, Yu C, Hoogenraad CC, Zhang M. PMID: 21855798.
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    144. New insights in endosomal dynamics and AMPA receptor trafficking. Semin Cell Dev Biol. 2011 Jul; 22(5):499-505. van der Sluijs P, Hoogenraad CC. PMID: 21843653.
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    145. Spinal inhibitory interneuron pathology follows motor neuron degeneration independent of glial mutant superoxide dismutase 1 expression in SOD1-ALS mice. J Neuropathol Exp Neurol. 2011 Aug; 70(8):662-77. Hossaini M, Cardona Cano S, van Dis V, Haasdijk ED, Hoogenraad CC, Holstege JC, Jaarsma D. PMID: 21760539.
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    146. βCaMKII plays a nonenzymatic role in hippocampal synaptic plasticity and learning by targeting αCaMKII to synapses. J Neurosci. 2011 Jul 13; 31(28):10141-8. Borgesius NZ, van Woerden GM, Buitendijk GH, Keijzer N, Jaarsma D, Hoogenraad CC, Elgersma Y. PMID: 21752990.
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    147. Absence of common somatic alterations in genes on 1p and 19q in oligodendrogliomas. PLoS One. 2011; 6(7):e22000. Bralten LB, Nouwens S, Kockx C, Erdem L, Hoogenraad CC, Kros JM, Moorhouse MJ, Sillevis Smitt PA, van der Spek P, van Ijcken W, Stubbs A, French PJ. PMID: 21760942.
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    148. SLAIN2 links microtubule plus end-tracking proteins and controls microtubule growth in interphase. J Cell Biol. 2011 Jun 13; 193(6):1083-99. van der Vaart B, Manatschal C, Grigoriev I, Olieric V, Gouveia SM, Bjelic S, Demmers J, Vorobjev I, Hoogenraad CC, Steinmetz MO, Akhmanova A. PMID: 21646404.
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    149. NMDA receptor activation suppresses microtubule growth and spine entry. J Neurosci. 2011 Jun 01; 31(22):8194-209. Kapitein LC, Yau KW, Gouveia SM, van der Zwan WA, Wulf PS, Keijzer N, Demmers J, Jaworski J, Akhmanova A, Hoogenraad CC. PMID: 21632941.
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    150. Centrosomes, microtubules and neuronal development. Mol Cell Neurosci. 2011 Dec; 48(4):349-58. Kuijpers M, Hoogenraad CC. PMID: 21722732.
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    151. Rab6, Rab8, and MICAL3 cooperate in controlling docking and fusion of exocytotic carriers. Curr Biol. 2011 Jun 07; 21(11):967-74. Grigoriev I, Yu KL, Martinez-Sanchez E, Serra-Marques A, Smal I, Meijering E, Demmers J, Peränen J, Pasterkamp RJ, van der Sluijs P, Hoogenraad CC, Akhmanova A. PMID: 21596566.
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    152. CLIP-170 and IQGAP1 cooperatively regulate dendrite morphology. J Neurosci. 2011 Mar 23; 31(12):4555-68. Swiech L, Blazejczyk M, Urbanska M, Pietruszka P, Dortland BR, Malik AR, Wulf PS, Hoogenraad CC, Jaworski J. PMID: 21430156.
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    154. Microtubule stabilization reduces scarring and causes axon regeneration after spinal cord injury. Science. 2011 Feb 18; 331(6019):928-31. Hellal F, Hurtado A, Ruschel J, Flynn KC, Laskowski CJ, Umlauf M, Kapitein LC, Strikis D, Lemmon V, Bixby J, Hoogenraad CC, Bradke F. PMID: 21273450.
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    155. Lentiviral transgenesis. Methods Mol Biol. 2011; 693:117-42. Nakagawa T, Hoogenraad CC. PMID: 21080278.
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    156. Isolation of novel +TIPs and their binding partners using affinity purification techniques. Methods Mol Biol. 2011; 777:293-316. Yu KL, Keijzer N, Hoogenraad CC, Akhmanova A. PMID: 21773937.
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    157. Dendritic spine plasticity: new regulatory roles of dynamic microtubules. Neuroscientist. 2010 Dec; 16(6):650-61. Hoogenraad CC, Akhmanova A. PMID: 21239729.
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    159. In vitro reconstitution of the functional interplay between MCAK and EB3 at microtubule plus ends. Curr Biol. 2010 Oct 12; 20(19):1717-22. Montenegro Gouveia S, Leslie K, Kapitein LC, Buey RM, Grigoriev I, Wagenbach M, Smal I, Meijering E, Hoogenraad CC, Wordeman L, Steinmetz MO, Akhmanova A. PMID: 20850319.
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    160. Which way to go? Cytoskeletal organization and polarized transport in neurons. Mol Cell Neurosci. 2011 Jan; 46(1):9-20. Kapitein LC, Hoogenraad CC. PMID: 20817096.
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    161. Stress hormones and AMPA receptor trafficking in synaptic plasticity and memory. Nat Rev Neurosci. 2010 Oct; 11(10):675-81. Krugers HJ, Hoogenraad CC, Groc L. PMID: 20820185.
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    162. GRASP-1 regulates endocytic receptor recycling and synaptic plasticity. Commun Integr Biol. 2010 Sep; 3(5):433-5. Hoogenraad CC, van der Sluijs P. PMID: 21057633.
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    164. Integrated genomic profiling identifies candidate genes implicated in glioma-genesis and a novel LEO1-SLC12A1 fusion gene. Genes Chromosomes Cancer. 2010 Jun; 49(6):509-17. Bralten LB, Kloosterhof NK, Gravendeel LA, Sacchetti A, Duijm EJ, Kros JM, van den Bent MJ, Hoogenraad CC, Sillevis Smitt PA, French PJ. PMID: 20196086.
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    165. Actin in dendritic spines: connecting dynamics to function. J Cell Biol. 2010 May 17; 189(4):619-29. Hotulainen P, Hoogenraad CC. PMID: 20457765.
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    167. Bicaudal D2, dynein, and kinesin-1 associate with nuclear pore complexes and regulate centrosome and nuclear positioning during mitotic entry. PLoS Biol. 2010 Apr 06; 8(4):e1000350. Splinter D, Tanenbaum ME, Lindqvist A, Jaarsma D, Flotho A, Yu KL, Grigoriev I, Engelsma D, Haasdijk ED, Keijzer N, Demmers J, Fornerod M, Melchior F, Hoogenraad CC, Medema RH, Akhmanova A. PMID: 20386726.
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    171. Neuron specific Rab4 effector GRASP-1 coordinates membrane specialization and maturation of recycling endosomes. PLoS Biol. 2010 Jan 19; 8(1):e1000283. Hoogenraad CC, Popa I, Futai K, Martinez-Sanchez E, Sanchez-Martinez E, Wulf PS, van Vlijmen T, Dortland BR, Oorschot V, Govers R, Monti M, Heck AJ, Sheng M, Klumperman J, Rehmann H, Jaarsma D, Kapitein LC, van der Sluijs P. PMID: 20098723.
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    203. GRIP1 controls dendrite morphogenesis by regulating EphB receptor trafficking. Nat Neurosci. 2005 Jul; 8(7):906-15. Hoogenraad CC, Milstein AD, Ethell IM, Henkemeyer M, Sheng M. PMID: 15965473.
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    204. LAR receptor protein tyrosine phosphatases in the development and maintenance of excitatory synapses. Nat Neurosci. 2005 Apr; 8(4):458-67. Dunah AW, Hueske E, Wyszynski M, Hoogenraad CC, Jaworski J, Pak DT, Simonetta A, Liu G, Sheng M. PMID: 15750591.
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    205. Microtubule plus-end-tracking proteins: mechanisms and functions. Curr Opin Cell Biol. 2005 Feb; 17(1):47-54. Akhmanova A, Hoogenraad CC. PMID: 15661518.
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    206. Conformational changes in CLIP-170 regulate its binding to microtubules and dynactin localization. J Cell Biol. 2004 Sep 27; 166(7):1003-14. Lansbergen G, Komarova Y, Modesti M, Wyman C, Hoogenraad CC, Goodson HV, Lemaitre RP, Drechsel DN, van Munster E, Gadella TW, Grosveld F, Galjart N, Borisy GG, Akhmanova A. PMID: 15381688.
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    207. LIMK1 and CLIP-115: linking cytoskeletal defects to Williams syndrome. Bioessays. 2004 Feb; 26(2):141-50. Hoogenraad CC, Akhmanova A, Galjart N, De Zeeuw CI. PMID: 14745832.
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    208. Bicaudal D induces selective dynein-mediated microtubule minus end-directed transport. EMBO J. 2003 Nov 17; 22(22):6004-15. Hoogenraad CC, Wulf P, Schiefermeier N, Stepanova T, Galjart N, Small JV, Grosveld F, de Zeeuw CI, Akhmanova A. PMID: 14609947.
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    209. The return of the exocyst. Nat Cell Biol. 2003 Jun; 5(6):493-5. Hoogenraad CC, Sheng M. PMID: 12776120.
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    210. Deformation of network connectivity in the inferior olive of connexin 36-deficient mice is compensated by morphological and electrophysiological changes at the single neuron level. J Neurosci. 2003 Jun 01; 23(11):4700-11. De Zeeuw CI, Chorev E, Devor A, Manor Y, Van Der Giessen RS, De Jeu MT, Hoogenraad CC, Bijman J, Ruigrok TJ, French P, Jaarsma D, Kistler WM, Meier C, Petrasch-Parwez E, Dermietzel R, Sohl G, Gueldenagel M, Willecke K, Yarom Y. PMID: 12805309.
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    211. Visualization of microtubule growth in cultured neurons via the use of EB3-GFP (end-binding protein 3-green fluorescent protein). J Neurosci. 2003 Apr 01; 23(7):2655-64. Stepanova T, Slemmer J, Hoogenraad CC, Lansbergen G, Dortland B, De Zeeuw CI, Grosveld F, van Cappellen G, Akhmanova A, Galjart N. PMID: 12684451.
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    212. Bicaudal-D regulates COPI-independent Golgi-ER transport by recruiting the dynein-dynactin motor complex. Nat Cell Biol. 2002 Dec; 4(12):986-92. Matanis T, Akhmanova A, Wulf P, Del Nery E, Weide T, Stepanova T, Galjart N, Grosveld F, Goud B, De Zeeuw CI, Barnekow A, Hoogenraad CC. PMID: 12447383.
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    213. Analysis of Cx36 knockout does not support tenet that olivary gap junctions are required for complex spike synchronization and normal motor performance. Ann N Y Acad Sci. 2002 Dec; 978:391-404. Kistler WM, De Jeu MT, Elgersma Y, Van Der Giessen RS, Hensbroek R, Luo C, Koekkoek SK, Hoogenraad CC, Hamers FP, Gueldenagel M, Sohl G, Willecke K, De Zeeuw CI. PMID: 12582068.
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    214. Targeted mutation of Cyln2 in the Williams syndrome critical region links CLIP-115 haploinsufficiency to neurodevelopmental abnormalities in mice. Nat Genet. 2002 Sep; 32(1):116-27. Hoogenraad CC, Koekkoek B, Akhmanova A, Krugers H, Dortland B, Miedema M, van Alphen A, Kistler WM, Jaegle M, Koutsourakis M, Van Camp N, Verhoye M, van der Linden A, Kaverina I, Grosveld F, De Zeeuw CI, Galjart N. PMID: 12195424.
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    215. LIS1, CLIP-170's key to the dynein/dynactin pathway. Mol Cell Biol. 2002 May; 22(9):3089-102. Coquelle FM, Caspi M, Cordelières FP, Dompierre JP, Dujardin DL, Koifman C, Martin P, Hoogenraad CC, Akhmanova A, Galjart N, De Mey JR, Reiner O. PMID: 11940666.
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    216. Hereditary familial vestibular degenerative diseases. Ann N Y Acad Sci. 2001 Oct; 942:493-6. Sun JC, Van Alphen AM, Wagenaar M, Huygen P, Hoogenraad CC, Hasson T, Koekkoek SK, Bohne BA, De Zeeuw CI. PMID: 11710498.
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    217. Mammalian Golgi-associated Bicaudal-D2 functions in the dynein-dynactin pathway by interacting with these complexes. EMBO J. 2001 Aug 01; 20(15):4041-54. Hoogenraad CC, Akhmanova A, Howell SA, Dortland BR, De Zeeuw CI, Willemsen R, Visser P, Grosveld F, Galjart N. PMID: 11483508.
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    218. Clasps are CLIP-115 and -170 associating proteins involved in the regional regulation of microtubule dynamics in motile fibroblasts. Cell. 2001 Mar 23; 104(6):923-35. Akhmanova A, Hoogenraad CC, Drabek K, Stepanova T, Dortland B, Verkerk T, Vermeulen W, Burgering BM, De Zeeuw CI, Grosveld F, Galjart N. PMID: 11290329.
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    219. Origin of vestibular dysfunction in Usher syndrome type 1B. Neurobiol Dis. 2001 Feb; 8(1):69-77. Sun JC, van Alphen AM, Wagenaar M, Huygen P, Hoogenraad CC, Hasson T, Koekkoek SK, Bohne BA, De Zeeuw CI. PMID: 11162241.
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    220. Functional analysis of CLIP-115 and its binding to microtubules. J Cell Sci. 2000 Jun; 113 ( Pt 12):2285-97. Hoogenraad CC, Akhmanova A, Grosveld F, De Zeeuw CI, Galjart N. PMID: 10825300.
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    221. The murine CYLN2 gene: genomic organization, chromosome localization, and comparison to the human gene that is located within the 7q11.23 Williams syndrome critical region. Genomics. 1998 Nov 01; 53(3):348-58. Hoogenraad CC, Eussen BH, Langeveld A, van Haperen R, Winterberg S, Wouters CH, Grosveld F, De Zeeuw CI, Galjart N. PMID: 9799601.
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    222. Microcircuitry and function of the inferior olive. Trends Neurosci. 1998 Sep; 21(9):391-400. De Zeeuw CI, Simpson JI, Hoogenraad CC, Galjart N, Koekkoek SK, Ruigrok TJ. PMID: 9735947.
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    223. CLIP-115, a novel brain-specific cytoplasmic linker protein, mediates the localization of dendritic lamellar bodies. Neuron. 1997 Dec; 19(6):1187-99. De Zeeuw CI, Hoogenraad CC, Goedknegt E, Hertzberg E, Neubauer A, Grosveld F, Galjart N. PMID: 9427243.
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