Jennifer Lavail • UCSF Profiles

Jennifer Lavail, PhD

Title(s)	Professor Emeritus, Anatomy
School	School of Medicine
Address	Location Required, #001
Email	jennifer.lavail@ucsf.edu
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Overview

Our lab investigates how Herpes simplex virus invade the central nervous system, using murine trigeminal ganglion cells and retinal ganglion cell as models for the study of herpes virus infections in humans. We use both in vivo and in vitro approaches.

Currently the lab is focused on three particular problems:

1. How newly synthesized virus spreads within axons to the next neurons;
2. Development of an in vitro model of axonal transport and encephalitic spread;
3. Development of a mutant HSV strain that can act as a native vaccine to block recurrent corneal keratitis or encephalis.

Research

Research Activities and Funding

Genetic analysis of Herpes virus neurotropism and encephalitis
NIH R01EY019159Sep 1, 2008 - Aug 31, 2013
Role: Principal Investigator

HSV and Host Cell Contributions to Corneal Infection
NIH R01EY013867May 1, 2002 - Apr 30, 2007
Role: Principal Investigator

Bio-Organic Biomedical Mass Spectrometry Resource
NIH P41RR001614Mar 1, 1982 - May 31, 2015
Role: Co-Investigator

Transport of Herpes Simplex Virus in Ocular Tissues
NIH R01EY008773Jul 1, 1978 - Mar 31, 2008
Role: Principal Investigator

AXONAL TRANSPORT IN THE VISUAL SYSTEM
NIH R01NS013533Jul 1, 1978 - Mar 31, 1990
Role: Principal Investigator

ORNG Applications

Academic Senate

Bibliographic

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

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A Model of In Vivo HSV-1 DNA Transport Using Murine Retinal Ganglion Cells. Methods Mol Biol. 2020; 2060:419-428. LaVail JH. PMID: 31617195.

View in: PubMed Mentions: Fields:
Mol Molecular Biology
Translation:Animals Cells
The Basic Domain of Herpes Simplex Virus 1 pUS9 Recruits Kinesin-1 To Facilitate Egress from Neurons. J Virol. 2016 02 15; 90(4):2102-11. Diefenbach RJ, Davis A, Miranda-Saksena M, Fernandez MA, Kelly BJ, Jones CA, LaVail JH, Xue J, Lai J, Cunningham AL. PMID: 26656703; PMCID: PMC4733978.

View in: PubMed Mentions: 41 Fields:
Vir Virology
Translation:Humans Animals Cells
In vivo HSV-1 DNA transport studies using murine retinal ganglion cells. Methods Mol Biol. 2014; 1144:283-92. Draper JM, Stephenson GS, LaVail JH. PMID: 24671691.

View in: PubMed Mentions: Fields:
Mol Molecular Biology
Translation:Humans Animals Cells
Delivery of herpes simplex virus to retinal ganglion cell axon is dependent on viral protein Us9. Invest Ophthalmol Vis Sci. 2013 Feb 01; 54(2):962-7. Draper JM, Huang G, Stephenson GS, Bertke AS, Cortez DA, LaVail JH. PMID: 23322573; PMCID: PMC3564453.

View in: PubMed Mentions: 6 Fields:
Oph Ophthalmology
Translation:Animals Cells
Viral regulation of the long distance axonal transport of herpes simplex virus nucleocapsid. Neuroscience. 2007 May 25; 146(3):974-85. LaVail JH, Tauscher AN, Sucher A, Harrabi O, Brandimarti R. PMID: 17382478; PMCID: PMC1945243.

View in: PubMed Mentions: 44 Fields:
Neu Neurology
Translation:Animals Cells
Characterization of a UL49-null mutant: VP22 of herpes simplex virus type 1 facilitates viral spread in cultured cells and the mouse cornea. J Virol. 2006 Sep; 80(17):8664-75. Duffy C, Lavail JH, Tauscher AN, Wills EG, Blaho JA, Baines JD. PMID: 16912314; PMCID: PMC1563855.

View in: PubMed Mentions: 59 Fields:
Vir Virology
Translation:Animals Cells
Genetic and molecular in vivo analysis of herpes simplex virus assembly in murine visual system neurons. J Virol. 2005 Sep; 79(17):11142-50. LaVail JH, Tauscher AN, Hicks JW, Harrabi O, Melroe GT, Knipe DM. PMID: 16103165; PMCID: PMC1193612.

View in: PubMed Mentions: 19 Fields:
Vir Virology
Translation:Animals Cells
Temporal expression of herpes simplex virus type 1 mRNA in murine retina. Curr Eye Res. 2004 Aug-Sep; 29(2-3):191-4. Harrabi O, Tauscher AN, LaVail JH. PMID: 15512966.

View in: PubMed Mentions: 1 Fields:
Oph Ophthalmology
Translation:Animals Cells
The microvesicle as a vehicle for EMMPRIN in tumor-stromal interactions. Oncogene. 2004 Jan 29; 23(4):956-63. Sidhu SS, Mengistab AT, Tauscher AN, LaVail J, Basbaum C. PMID: 14749763.

View in: PubMed Mentions: 110 Fields:
Mol Molecular Biology Neo Neoplasms
Translation:Humans Cells
A procedure to deliver herpes simplex virus to the murine trigeminal ganglion. Brain Res Brain Res Protoc. 2003 Aug; 12(1):60-6. Whitehead JL, Ohara PT, Tauscher AN, LaVail JH. PMID: 12928046.

View in: PubMed Mentions: 10 Fields:
Bra Brain
Translation:Animals Cells
Axonal transport and sorting of herpes simplex virus components in a mature mouse visual system. J Virol. 2003 Jun; 77(11):6117-26. LaVail JH, Tauscher AN, Aghaian E, Harrabi O, Sidhu SS. PMID: 12743269; PMCID: PMC155024.

View in: PubMed Mentions: 15 Fields:
Vir Virology
Translation:Animals Cells
Two paths for dissemination of Herpes simplex virus from infected trigeminal ganglion to the murine cornea. Brain Res. 2001 Apr 27; 899(1-2):260-3. Ohara PT, Tauscher AN, LaVail JH. PMID: 11311889.

View in: PubMed Mentions: 9 Fields:
Bra Brain
Translation:Animals Cells
Retrograde axonal transport of herpes simplex virus: evidence for a single mechanism and a role for tegument. Proc Natl Acad Sci U S A. 2000 Jul 05; 97(14):8146-50. Bearer EL, Breakefield XO, Schuback D, Reese TS, LaVail JH. PMID: 10884436; PMCID: PMC16684.

View in: PubMed Mentions: 69 Fields:
Sci Science
Translation:Animals Cells
The spread of herpes simplex virus type 1 from trigeminal neurons to the murine cornea: an immunoelectron microscopy study. J Virol. 2000 May; 74(10):4776-86. Ohara PT, Chin MS, LaVail JH. PMID: 10775616; PMCID: PMC112000.

View in: PubMed Mentions: 31 Fields:
Vir Virology
Translation:Humans Animals Cells
Squid axoplasm supports the retrograde axonal transport of herpes simplex virus. Biol Bull. 1999 Oct; 197(2):257-8. Bearer EL, Schlief ML, Breakefield XO, Schuback DE, Reese TS, LaVail JH. PMID: 10573844; PMCID: PMC3376079.

View in: PubMed Mentions: 4 Fields:
Bio Biology
Translation:Humans Animals Cells
Differential anterograde transport of HSV type 1 viral strains in the murine optic pathway. J Neurovirol. 1999 Apr; 5(2):140-50. Garner JA, LaVail JH. PMID: 10321978.

View in: PubMed Mentions: 21 Fields:
Neu Neurology Vir Virology
Translation:Humans Animals Cells
Factors that contribute to the transneuronal spread of herpes simplex virus. J Neurosci Res. 1997 Aug 15; 49(4):485-96. LaVail JH, Topp KS, Giblin PA, Garner JA. PMID: 9285524.

View in: PubMed Mentions: 39 Fields:
Neu Neurology
Translation:Animals Cells
Herpes virus infection of RPE and MDCK cells: polarity of infection. Exp Eye Res. 1997 Mar; 64(3):343-54. Topp KS, Rothman AL, Lavail JH. PMID: 9196385.

View in: PubMed Mentions: 11 Fields:
Oph Ophthalmology
Translation:Humans Animals Cells
Centripetal transport of herpes simplex virus in human retinal pigment epithelial cells in vitro. Neuroscience. 1996 Apr; 71(4):1133-44. Topp KS, Bisla K, Saks ND, Lavail JH. PMID: 8684617.

View in: PubMed Mentions: 13 Fields:
Neu Neurology
Translation:Humans Cells
Microtubule polarity in the peripheral processes of trigeminal ganglion cells: relevance for the retrograde transport of herpes simplex virus. J Neurosci. 1994 Jan; 14(1):318-25. Topp KS, Meade LB, LaVail JH. PMID: 8283239; PMCID: PMC6576856.

View in: PubMed Mentions: 39 Fields:
Neu Neurology
Translation:Animals Cells
The retrograde tracer Fluoro-Gold interferes with the infectivity of herpes simplex virus. Brain Res. 1993 Oct 15; 625(1):57-62. LaVail JH, Carter SR, Topp KS. PMID: 8242400.

View in: PubMed Mentions: 3 Fields:
Bra Brain
Translation:Animals Cells
Immunohistochemical identification of trigeminal ganglion neurons that innervate the mouse cornea: relevance to intercellular spread of herpes simplex virus. J Comp Neurol. 1993 Jan 01; 327(1):133-40. LaVail JH, Johnson WE, Spencer LC. PMID: 7679419.

View in: PubMed Mentions: 15 Fields:
Neu Neurology
Translation:Animals Cells
A quantitative assay of retrograde transported HSV in the trigeminal ganglion. Invest Ophthalmol Vis Sci. 1992 May; 33(6):1934-9. Carter SR, Pereira L, Paz P, LaVail JH. PMID: 1316334.

View in: PubMed Mentions: Fields:
Oph Ophthalmology
Translation:Animals Cells
Herpes simplex viral infection of the mouse trigeminal ganglion. Immunohistochemical analysis of cell populations. Invest Ophthalmol Vis Sci. 1992 Feb; 33(2):259-67. Margolis TP, Dawson CR, LaVail JH. PMID: 1371269.

View in: PubMed Mentions: 32 Fields:
Oph Ophthalmology
Translation:Animals Cells
Ultrastructural immunocytochemical localization of herpes simplex virus (type 1) in trigeminal ganglion neurons. Curr Eye Res. 1991; 10 Suppl:23-9. LaVail JH, Meade LB, Dawson CR. PMID: 1650670.

View in: PubMed Mentions: 3 Fields:
Oph Ophthalmology
Translation:Animals Cells
HSV (type 1) infection of the trigeminal complex. Brain Res. 1990 Apr 30; 514(2):181-8. LaVail JH, Zhan J, Margolis TP. PMID: 2357535.

View in: PubMed Mentions: 3 Fields:
Bra Brain
Translation:Animals
Selective spread of herpes simplex virus in the central nervous system after ocular inoculation. J Virol. 1989 Nov; 63(11):4756-61. Margolis TP, LaVail JH, Setzer PY, Dawson CR. PMID: 2552151; PMCID: PMC251112.

View in: PubMed Mentions: 14 Fields:
Vir Virology
Translation:Animals Cells
Further evidence in support of the selective uptake and anterograde transport of [125I]wheat germ agglutinin by chick retinal ganglion cells. Brain Res. 1984 Dec 17; 324(1):21-7. Margolis TP, LaVail JH. PMID: 6083824.

View in: PubMed Mentions: 1 Fields:
Bra Brain
Translation:Animals Cells
Localization of axonally transported label in chick retinal ganglion cell axons after intravitreal injections of wheat germ agglutinin conjugated to horseradish peroxidase. Brain Res. 1984 Jun 18; 304(1):59-69. LaVail JH, Sugino IK. PMID: 6204718.

View in: PubMed Mentions: Fields:
Bra Brain
Translation:Animals Cells
Assessment of possible transneuronal changes in the retina of rats with inherited retinal dystrophy: cell size, number, synapses, and axonal transport by retinal ganglion cells. J Comp Neurol. 1984 Feb 10; 223(1):22-34. Eisenfeld AJ, LaVail MM, LaVail JH. PMID: 6200511.

View in: PubMed Mentions: 11 Fields:
Neu Neurology
Translation:Animals Cells
Localization of axonally transported 125I-wheat germ agglutinin beneath the plasma membrane of chick retinal ganglion cells. J Cell Biol. 1983 Feb; 96(2):373-81. LaVail JH, Sugino IK, McDonald DM. PMID: 6187749; PMCID: PMC2112277.

View in: PubMed Mentions: 7 Fields:
Cel Cell Biology
Translation:Animals Cells
Penetration of horseradish peroxidase into the optic nerve after vitreal or vascular injections in the developing chick. Invest Ophthalmol Vis Sci. 1981 Jun; 20(6):705-16. Kistler HB, LaVail JH. PMID: 6165700.

View in: PubMed Mentions: 2 Fields:
Oph Ophthalmology
Translation:Animals
Evidence against the smooth endoplasmic reticulum as a continuous channel for the retrograde axonal transport of horseradish peroxidase. Brain Res. 1980 Jun 02; 191(1):3-20. Lavail JH, Rapisardi S, Sugino IK. PMID: 6155169.

View in: PubMed Mentions: 8 Fields:
Bra Brain
Translation:Animals Cells
Retrograde intraaxonal transport of horseradish peroxidase in retinal ganglion cells of the chick. Brain Res. 1975 Feb 28; 85(2):273-80. LaVail MM, LaVail JH. PMID: 46164.

View in: PubMed Mentions: 14 Fields:
Bra Brain
Translation:Animals Cells
The retrograde intraaxonal transport of horseradish peroxidase in the chick visual system: a light and electron microscopic study. J Comp Neurol. 1974 Oct 01; 157(3):303-57. LaVail JH, LaVail MM. PMID: 4138789.

View in: PubMed Mentions: 70 Fields:
Neu Neurology
Translation:Animals Cells
Retrograde axonal transport in the central nervous system. Science. 1972 Jun 30; 176(4042):1416-7. LaVail JH, LaVail MM. PMID: 5033648.

View in: PubMed Mentions: 102 Fields:
Sci Science
Translation:Animals Cells