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Jennifer Lavail, PhD

TitleProfessor Emeritus
InstitutionUniversity of California San Francisco
DepartmentAnatomy
Address550 16th Street
San Francisco CA 94158
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    Collapse Overview 
    Collapse Overview
    Our lab investigates how Herpes simplex virus invade the central nervous system, using murine trigeminal ganglion cells and retinal ganglion cell as models for the study of herpes virus infections in humans. We use both in vivo and in vitro approaches.

    Currently the lab is focused on three particular problems:

    1. How newly synthesized virus spreads within axons to the next neurons;
    2. Development of an in vitro model of axonal transport and encephalitic spread;
    3. Development of a mutant HSV strain that can act as a native vaccine to block recurrent corneal keratitis or encephalis.


    Collapse Research 
    Collapse Research Activities and Funding
    Genetic analysis of Herpes virus neurotropism and encephalitis
    NIH/NEI R01EY019159Sep 1, 2008 - Aug 31, 2013
    Role: Principal Investigator
    HSV and Host Cell Contributions to Corneal Infection
    NIH/NEI R01EY013867May 1, 2002 - Apr 30, 2007
    Role: Principal Investigator
    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator
    Transport of Herpes Simplex Virus in Ocular Tissues
    NIH/NEI R01EY008773Jul 1, 1978 - Mar 31, 2008
    Role: Principal Investigator
    AXONAL TRANSPORT IN THE VISUAL SYSTEM
    NIH/NINDS R01NS013533Jul 1, 1978 - Mar 31, 1990
    Role: Principal Investigator

    Collapse ORNG Applications 
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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Diefenbach RJ, Davis A, Miranda-Saksena M, Fernandez MA, Kelly BJ, Jones CA, LaVail JH, Xue J, Lai J, Cunningham AL. The Basic Domain of Herpes Simplex Virus 1 pUS9 Recruits Kinesin-1 To Facilitate Egress from Neurons. J Virol. 2016 02 15; 90(4):2102-11. PMID: 26656703.
      View in: PubMed
    2. Draper JM, Stephenson GS, LaVail JH. In vivo HSV-1 DNA transport studies using murine retinal ganglion cells. Methods Mol Biol. 2014; 1144:283-92. PMID: 24671691.
      View in: PubMed
    3. Draper JM, Huang G, Stephenson GS, Bertke AS, Cortez DA, LaVail JH. Delivery of herpes simplex virus to retinal ganglion cell axon is dependent on viral protein Us9. Invest Ophthalmol Vis Sci. 2013 Feb 01; 54(2):962-7. PMID: 23322573; PMCID: PMC3564453.
    4. LaVail JH, Tauscher AN, Sucher A, Harrabi O, Brandimarti R. Viral regulation of the long distance axonal transport of herpes simplex virus nucleocapsid. Neuroscience. 2007 May 25; 146(3):974-85. PMID: 17382478; PMCID: PMC1945243.
    5. Duffy C, Lavail J, Tauscher AN, Wills EG, Blaho JA, Baines JD. Characterization of a UL49-null mutant: VP22 of herpes simplex virus type 1 facilitates viral spread in cultured cells and the mouse cornea. J Virol. 2006 Sep; 80(17):8664-75. PMID: 16912314; PMCID: PMC1563855.
    6. LaVail JH, Tauscher AN, Hicks JW, Harrabi O, Melroe GT, Knipe DM. Genetic and molecular in vivo analysis of herpes simplex virus assembly in murine visual system neurons. J Virol. 2005 Sep; 79(17):11142-50. PMID: 16103165; PMCID: PMC1193612.
    7. Harrabi O, Tauscher AN, LaVail JH. Temporal expression of herpes simplex virus type 1 mRNA in murine retina. Curr Eye Res. 2004 Aug-Sep; 29(2-3):191-4. PMID: 15512966.
      View in: PubMed
    8. Sidhu SS, Mengistab AT, Tauscher AN, LaVail J, Basbaum C. The microvesicle as a vehicle for EMMPRIN in tumor-stromal interactions. Oncogene. 2004 Jan 29; 23(4):956-63. PMID: 14749763.
      View in: PubMed
    9. Whitehead JL, Ohara PT, Tauscher AN, LaVail JH. A procedure to deliver herpes simplex virus to the murine trigeminal ganglion. Brain Res Brain Res Protoc. 2003 Aug; 12(1):60-6. PMID: 12928046.
      View in: PubMed
    10. LaVail JH, Tauscher AN, Aghaian E, Harrabi O, Sidhu SS. Axonal transport and sorting of herpes simplex virus components in a mature mouse visual system. J Virol. 2003 Jun; 77(11):6117-26. PMID: 12743269; PMCID: PMC155024.
    11. Ohara PT, Tauscher AN, LaVail JH. Two paths for dissemination of Herpes simplex virus from infected trigeminal ganglion to the murine cornea. Brain Res. 2001 Apr 27; 899(1-2):260-3. PMID: 11311889.
      View in: PubMed
    12. Bearer EL, Breakefield XO, Schuback D, Reese TS, LaVail JH. Retrograde axonal transport of herpes simplex virus: evidence for a single mechanism and a role for tegument. Proc Natl Acad Sci U S A. 2000 Jul 05; 97(14):8146-50. PMID: 10884436; PMCID: PMC16684.
    13. Ohara PT, Chin MS, LaVail JH. The spread of herpes simplex virus type 1 from trigeminal neurons to the murine cornea: an immunoelectron microscopy study. J Virol. 2000 May; 74(10):4776-86. PMID: 10775616; PMCID: PMC112000.
    14. Bearer EL, Schlief ML, Breakefield XO, Schuback DE, Reese TS, LaVail JH. Squid axoplasm supports the retrograde axonal transport of herpes simplex virus. Biol Bull. 1999 Oct; 197(2):257-8. PMID: 10573844; PMCID: PMC3376079.
    15. Garner JA, LaVail JH. Differential anterograde transport of HSV type 1 viral strains in the murine optic pathway. J Neurovirol. 1999 Apr; 5(2):140-50. PMID: 10321978.
      View in: PubMed
    16. LaVail JH, Topp KS, Giblin PA, Garner JA. Factors that contribute to the transneuronal spread of herpes simplex virus. J Neurosci Res. 1997 Aug 15; 49(4):485-96. PMID: 9285524.
      View in: PubMed
    17. Topp KS, Rothman AL, Lavail J. Herpes virus infection of RPE and MDCK cells: polarity of infection. Exp Eye Res. 1997 Mar; 64(3):343-54. PMID: 9196385.
      View in: PubMed
    18. Topp KS, Bisla K, Saks ND, Lavail J. Centripetal transport of herpes simplex virus in human retinal pigment epithelial cells in vitro. Neuroscience. 1996 Apr; 71(4):1133-44. PMID: 8684617.
      View in: PubMed
    19. Topp KS, Meade LB, LaVail JH. Microtubule polarity in the peripheral processes of trigeminal ganglion cells: relevance for the retrograde transport of herpes simplex virus. J Neurosci. 1994 Jan; 14(1):318-25. PMID: 8283239.
      View in: PubMed
    20. LaVail JH, Carter SR, Topp KS. The retrograde tracer Fluoro-Gold interferes with the infectivity of herpes simplex virus. Brain Res. 1993 Oct 15; 625(1):57-62. PMID: 8242400.
      View in: PubMed
    21. LaVail JH, Johnson WE, Spencer LC. Immunohistochemical identification of trigeminal ganglion neurons that innervate the mouse cornea: relevance to intercellular spread of herpes simplex virus. J Comp Neurol. 1993 Jan 01; 327(1):133-40. PMID: 7679419.
      View in: PubMed
    22. Carter SR, Pereira L, Paz P, LaVail JH. A quantitative assay of retrograde transported HSV in the trigeminal ganglion. Invest Ophthalmol Vis Sci. 1992 May; 33(6):1934-9. PMID: 1316334.
      View in: PubMed
    23. Margolis TP, Dawson CR, LaVail JH. Herpes simplex viral infection of the mouse trigeminal ganglion. Immunohistochemical analysis of cell populations. Invest Ophthalmol Vis Sci. 1992 Feb; 33(2):259-67. PMID: 1371269.
      View in: PubMed
    24. LaVail JH, Meade LB, Dawson CR. Ultrastructural immunocytochemical localization of herpes simplex virus (type 1) in trigeminal ganglion neurons. Curr Eye Res. 1991; 10 Suppl:23-9. PMID: 1650670.
      View in: PubMed
    25. LaVail JH, Zhan J, Margolis TP. HSV (type 1) infection of the trigeminal complex. Brain Res. 1990 Apr 30; 514(2):181-8. PMID: 2357535.
      View in: PubMed
    26. Margolis TP, LaVail JH, Setzer PY, Dawson CR. Selective spread of herpes simplex virus in the central nervous system after ocular inoculation. J Virol. 1989 Nov; 63(11):4756-61. PMID: 2552151; PMCID: PMC251112.
    27. Margolis TP, LaVail JH. Further evidence in support of the selective uptake and anterograde transport of [125I]wheat germ agglutinin by chick retinal ganglion cells. Brain Res. 1984 Dec 17; 324(1):21-7. PMID: 6083824.
      View in: PubMed
    28. LaVail JH, Sugino IK. Localization of axonally transported label in chick retinal ganglion cell axons after intravitreal injections of wheat germ agglutinin conjugated to horseradish peroxidase. Brain Res. 1984 Jun 18; 304(1):59-69. PMID: 6204718.
      View in: PubMed
    29. Eisenfeld AJ, LaVail MM, LaVail JH. Assessment of possible transneuronal changes in the retina of rats with inherited retinal dystrophy: cell size, number, synapses, and axonal transport by retinal ganglion cells. J Comp Neurol. 1984 Feb 10; 223(1):22-34. PMID: 6200511.
      View in: PubMed
    30. Kistler HB, LaVail JH. Penetration of horseradish peroxidase into the optic nerve after vitreal or vascular injections in the developing chick. Invest Ophthalmol Vis Sci. 1981 Jun; 20(6):705-16. PMID: 6165700.
      View in: PubMed
    31. LaVail MM, LaVail JH. Retrograde intraaxonal transport of horseradish peroxidase in retinal ganglion cells of the chick. Brain Res. 1975 Feb 28; 85(2):273-80. PMID: 46164.
      View in: PubMed
    32. LaVail JH, LaVail MM. The retrograde intraaxonal transport of horseradish peroxidase in the chick visual system: a light and electron microscopic study. J Comp Neurol. 1974 Oct 01; 157(3):303-57. PMID: 4138789.
      View in: PubMed
    33. LaVail JH, LaVail MM. Retrograde axonal transport in the central nervous system. Science. 1972 Jun 30; 176(4042):1416-7. PMID: 5033648.
      View in: PubMed
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