Julio Leon Incio, PhD

TitlePostdoctoral Scholar
SchoolUCSF School of Medicine
Address675 Nelson Rising Lane
San Francisco CA 94158
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    Collapse Biography 
    Collapse Education and Training
    Kysuhu University, JAPANPhD04/2016Neuromolecular Biology and Functional Genomics
    Kyushu University, JAPANMSc04/2012Biochemistry and Cell Signaling
    National University of TrujilloBSc2007Biology
    Collapse Awards and Honors
    Kyushu University2015  - 2015Kyushu University Fund
    Ministry of Education and Science Japan2009  - 2016MOMBUKAGAKUSHO Scholarship
    National University of Trujillo2014  - 2014Antonio Samanamud Romero distinction award

    Collapse Overview 
    Collapse Overview
    "A person's mental activities are entirely due to the behaviour of nerve cells, glial cells, and the atoms, ions, and molecules that make them up and influence them." This is what the Nobel laureate Francis Crick asserted in his book, "The Astonishing Hypothesis". In accordance with it, I believe that the amazing complexity of our mind, are hidden in the yet not well-understood molecular mechanisms that rule our cellular functions. Unraveling such mechanisms is crucial not only for the the better understanding of life, but also for the great impact that this implies for humanity, since this knowledge will increase our chances to find cures for neurodegenerative diseases, such us Alzheimer’s or Parkinson disease.

    I am a Peruvian scientist trained in functional genomics, molecular biology, and biochemistry at Kyushu University Japan. I am member of Dr. Dubal's laboratory trying to better understand the specialised roles of mitochondria in the brain with the target of boosting its function during aging and disease opening a new approach to treat neurodegenerative disorders.

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Leon J, Moreno AJ, Garay BI, Chalkley RJ, Burlingame AL, Wang D, Dubal DB. Peripheral Elevation of a Klotho Fragment Enhances Brain Function and Resilience in Young, Aging, and a-Synuclein Transgenic Mice. Cell Rep. 2017 Aug 08; 20(6):1360-1371. PMID: 28793260.
      View in: PubMed
    2. Oka S, Leon J, Sakumi K, Ide T, Kang D, LaFerla FM, Nakabeppu Y. Human mitochondrial transcriptional factor A breaks the mitochondria-mediated vicious cycle in Alzheimer's disease. Sci Rep. 2016 Nov 29; 6:37889. PMID: 27897204.
      View in: PubMed
    3. Abolhassani N, Leon J, Sheng Z, Oka S, Hamasaki H, Iwaki T, Nakabeppu Y. Molecular pathophysiology of impaired glucose metabolism, mitochondrial dysfunction, and oxidative DNA damage in Alzheimer's disease brain. Mech Ageing Dev. 2017 Jan; 161(Pt A):95-104. PMID: 27233446.
      View in: PubMed
    4. Leon J, Sakumi K, Castillo E, Sheng Z, Oka S, Nakabeppu Y. 8-Oxoguanine accumulation in mitochondrial DNA causes mitochondrial dysfunction and impairs neuritogenesis in cultured adult mouse cortical neurons under oxidative conditions. Sci Rep. 2016 Feb 25; 6:22086. PMID: 26912170; PMCID: PMC4766534.
    5. Oka S, Leon J, Tsuchimoto D, Sakumi K, Nakabeppu Y. MUTYH, an adenine DNA glycosylase, mediates p53 tumor suppression via PARP-dependent cell death. Oncogenesis. 2014 Oct 13; 3:e121. PMID: 25310643; PMCID: PMC4216901.
    6. Hokama M, Oka S, Leon J, Ninomiya T, Honda H, Sasaki K, Iwaki T, Ohara T, Sasaki T, LaFerla FM, Kiyohara Y, Nakabeppu Y. Altered expression of diabetes-related genes in Alzheimer's disease brains: the Hisayama study. Cereb Cortex. 2014 Sep; 24(9):2476-88. PMID: 23595620; PMCID: PMC4128707.
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