Julio Leon Incio, PhD, MSc
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| Title(s) | Postdoctoral Scholar, Institute for Neurodegenerative Diseases |
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| School | School of Medicine |
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| Address | 675 Nelson Rising Lane, #301A
San Francisco CA 94158
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| Phone | 415-502-7171 |
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| Pronouns | He/Him/His |
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ORCID
.gif) | 0000-0002-1113-4544  |
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| vCard | Download vCard |
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Biography
| Kysuhu University, JAPAN | PhD | 04/2016 | Molecular Neuroscience and Functional Genomics |
| Kyushu University, JAPAN | MSc | 04/2012 | Biochemistry and Cell Signaling |
| National University of Trujillo | BSc | 2007 | Molecular Biology |
| Kyushu University | 2015
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| 2015 | Kyushu University Fund |
| Ministry of Education and Science Japan | 2009
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| 2016 | MOMBUKAGAKUSHO Scholarship |
| National University of Trujillo | 2014
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| 2014 | Antonio Samanamud Romero distinction award |
Overview
I am a molecular and genomics neuroscientist using experimental and computational approaches to understand how alterations in individual cells affect brain function in aging and disease. Given the intricate spatial wiring of our brain, my research focuses on identifying molecular changes in individual cells with spatial context integrating single-cell and spatial transcriptomics.
My research experience spans the analysis of postmortem brain samples, in vivo and in vitro disease modeling studies, and the analysis of bulk, single-cell, and spatial transcriptomics data. I am skilled in interpreting multi-omics data to discover biological mechanisms, with solid training in R programming, data visualization, and statistical tests. My ultimate goal is to contribute to developing disease-modifying therapeutic interventions.
Throughout my diverse professional journey, I have worked independently and collaboratively in different countries, including Peru, Canada, the USA, and Japan. I have established a vast network and mentored students from various nationalities and backgrounds.
Bibliographic
Altmetrics Details
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media.
(Note that publications are often cited in additional ways that are not shown here.)
Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication.
Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication.
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KL1 Domain of Longevity Factor Klotho Mimics the Metabolome of Cognitive Stimulation and Enhances Cognition in Young and Aging Mice. J Neurosci. 2022 05 11; 42(19):4016-4025.
Gupta S, Moreno AJ, Wang D, Leon J, Chen C, Hahn O, Poon Y, Greenberg K, David N, Wyss-Coray T, Raftery D, Promislow DEL, Dubal DB. PMID: 35428698; PMCID: PMC9097772.
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PubMed Mentions:
9 Fields:
Translation:
Animals
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MTH1 and OGG1 maintain a low level of 8-oxoguanine in Alzheimer's brain, and prevent the progression of Alzheimer's pathogenesis. Sci Rep. 2021 03 23; 11(1):5819.
Oka S, Leon J, Sakumi K, Abolhassani N, Sheng Z, Tsuchimoto D, LaFerla FM, Nakabeppu Y. PMID: 33758207; PMCID: PMC7988129.
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PubMed Mentions:
17 Fields:
Translation:
HumansAnimalsCells
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Comparative profiling of cortical gene expression in Alzheimer's disease patients and mouse models demonstrates a link between amyloidosis and neuroinflammation. Sci Rep. 2017 12 19; 7(1):17762.
Castillo E, Leon J, Mazzei G, Abolhassani N, Haruyama N, Saito T, Saido T, Hokama M, Iwaki T, Ohara T, Ninomiya T, Kiyohara Y, Sakumi K, LaFerla FM, Nakabeppu Y. PMID: 29259249; PMCID: PMC5736730.
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PubMed Mentions:
85 Fields:
Translation:
HumansAnimals
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Peripheral Elevation of a Klotho Fragment Enhances Brain Function and Resilience in Young, Aging, and α-Synuclein Transgenic Mice. Cell Rep. 2017 08 08; 20(6):1360-1371.
Leon J, Moreno AJ, Garay BI, Chalkley RJ, Burlingame AL, Wang D, Dubal DB. PMID: 28793260; PMCID: PMC5816951.
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PubMed Mentions:
59 Fields:
Translation:
AnimalsCells
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Human mitochondrial transcriptional factor A breaks the mitochondria-mediated vicious cycle in Alzheimer's disease. Sci Rep. 2016 11 29; 6:37889.
Oka S, Leon J, Sakumi K, Ide T, Kang D, LaFerla FM, Nakabeppu Y. PMID: 27897204; PMCID: PMC5126576.
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PubMed Mentions:
41 Fields:
Translation:
HumansAnimalsCells
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Molecular pathophysiology of impaired glucose metabolism, mitochondrial dysfunction, and oxidative DNA damage in Alzheimer's disease brain. Mech Ageing Dev. 2017 01; 161(Pt A):95-104.
Abolhassani N, Leon J, Sheng Z, Oka S, Hamasaki H, Iwaki T, Nakabeppu Y. PMID: 27233446.
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PubMed Mentions:
56 Fields:
Translation:
HumansCells
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8-Oxoguanine accumulation in mitochondrial DNA causes mitochondrial dysfunction and impairs neuritogenesis in cultured adult mouse cortical neurons under oxidative conditions. Sci Rep. 2016 Feb 25; 6:22086.
Leon J, Sakumi K, Castillo E, Sheng Z, Oka S, Nakabeppu Y. PMID: 26912170; PMCID: PMC4766534.
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PubMed Mentions:
38 Fields:
Translation:
AnimalsCells
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MUTYH, an adenine DNA glycosylase, mediates p53 tumor suppression via PARP-dependent cell death. Oncogenesis. 2014 Oct 13; 3:e121.
Oka S, Leon J, Tsuchimoto D, Sakumi K, Nakabeppu Y. PMID: 25310643; PMCID: PMC4216901.
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PubMed Mentions:
22
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Altered expression of diabetes-related genes in Alzheimer's disease brains: the Hisayama study. Cereb Cortex. 2014 Sep; 24(9):2476-88.
Hokama M, Oka S, Leon J, Ninomiya T, Honda H, Sasaki K, Iwaki T, Ohara T, Sasaki T, LaFerla FM, Kiyohara Y, Nakabeppu Y. PMID: 23595620; PMCID: PMC4128707.
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PubMed Mentions:
145 Fields:
Translation:
HumansAnimals
This graph shows the total number of publications by year. To see the data as text,
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| Year | Publications |
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| 2013 | 1 |
| 2014 | 1 |
| 2016 | 3 |
| 2017 | 2 |
| 2021 | 1 |
| 2022 | 1 |
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This graph shows the number and percent of publications by field.
Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications.
Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
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