Julio Leon Incio, PhD, MSc

Title(s)Postdoctoral Scholar, Institute for Neurodegenerative Diseases
SchoolSchool of Medicine
ORCID ORCID Icon0000-0002-1113-4544 Additional info
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    Collapse Biography 
    Collapse Education and Training
    Kysuhu University, JAPANPhD04/2016Molecular Neuroscience and Functional Genomics
    Kyushu University, JAPANMSc04/2012Biochemistry and Cell Signaling
    National University of TrujilloBSc2007Molecular Biology
    Collapse Awards and Honors
    Kyushu University2015  - 2015Kyushu University Fund
    Ministry of Education and Science Japan2009  - 2016MOMBUKAGAKUSHO Scholarship
    National University of Trujillo2014  - 2014Antonio Samanamud Romero distinction award

    Collapse Overview 
    Collapse Overview
    I am a molecular and genomics neuroscientist using experimental and computational approaches to understand how alterations in individual cells affect brain function in aging and disease. Given the intricate spatial wiring of our brain, my research focuses on identifying molecular changes in individual cells with spatial context integrating single-cell and spatial transcriptomics.
    My research experience spans the analysis of postmortem brain samples, in vivo and in vitro disease modeling studies, and the analysis of bulk, single-cell, and spatial transcriptomics data. I am skilled in interpreting multi-omics data to discover biological mechanisms, with solid training in R programming, data visualization, and statistical tests. My ultimate goal is to contribute to developing disease-modifying therapeutic interventions.

    Throughout my diverse professional journey, I have worked independently and collaboratively in different countries, including Peru, Canada, the USA, and Japan. I have established a vast network and mentored students from various nationalities and backgrounds.

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. KL1 Domain of Longevity Factor Klotho Mimics the Metabolome of Cognitive Stimulation and Enhances Cognition in Young and Aging Mice. J Neurosci. 2022 05 11; 42(19):4016-4025. Gupta S, Moreno AJ, Wang D, Leon J, Chen C, Hahn O, Poon Y, Greenberg K, David N, Wyss-Coray T, Raftery D, Promislow DEL, Dubal DB. PMID: 35428698; PMCID: PMC9097772.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    2. MTH1 and OGG1 maintain a low level of 8-oxoguanine in Alzheimer's brain, and prevent the progression of Alzheimer's pathogenesis. Sci Rep. 2021 03 23; 11(1):5819. Oka S, Leon J, Sakumi K, Abolhassani N, Sheng Z, Tsuchimoto D, LaFerla FM, Nakabeppu Y. PMID: 33758207; PMCID: PMC7988129.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    3. Comparative profiling of cortical gene expression in Alzheimer's disease patients and mouse models demonstrates a link between amyloidosis and neuroinflammation. Sci Rep. 2017 12 19; 7(1):17762. Castillo E, Leon J, Mazzei G, Abolhassani N, Haruyama N, Saito T, Saido T, Hokama M, Iwaki T, Ohara T, Ninomiya T, Kiyohara Y, Sakumi K, LaFerla FM, Nakabeppu Y. PMID: 29259249; PMCID: PMC5736730.
      View in: PubMed   Mentions: 80     Fields:    Translation:HumansAnimals
    4. Peripheral Elevation of a Klotho Fragment Enhances Brain Function and Resilience in Young, Aging, and α-Synuclein Transgenic Mice. Cell Rep. 2017 08 08; 20(6):1360-1371. Leon J, Moreno AJ, Garay BI, Chalkley RJ, Burlingame AL, Wang D, Dubal DB. PMID: 28793260; PMCID: PMC5816951.
      View in: PubMed   Mentions: 52     Fields:    Translation:AnimalsCells
    5. Human mitochondrial transcriptional factor A breaks the mitochondria-mediated vicious cycle in Alzheimer's disease. Sci Rep. 2016 11 29; 6:37889. Oka S, Leon J, Sakumi K, Ide T, Kang D, LaFerla FM, Nakabeppu Y. PMID: 27897204; PMCID: PMC5126576.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    6. Molecular pathophysiology of impaired glucose metabolism, mitochondrial dysfunction, and oxidative DNA damage in Alzheimer's disease brain. Mech Ageing Dev. 2017 01; 161(Pt A):95-104. Abolhassani N, Leon J, Sheng Z, Oka S, Hamasaki H, Iwaki T, Nakabeppu Y. PMID: 27233446.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansCells
    7. 8-Oxoguanine accumulation in mitochondrial DNA causes mitochondrial dysfunction and impairs neuritogenesis in cultured adult mouse cortical neurons under oxidative conditions. Sci Rep. 2016 Feb 25; 6:22086. Leon J, Sakumi K, Castillo E, Sheng Z, Oka S, Nakabeppu Y. PMID: 26912170; PMCID: PMC4766534.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    8. MUTYH, an adenine DNA glycosylase, mediates p53 tumor suppression via PARP-dependent cell death. Oncogenesis. 2014 Oct 13; 3:e121. Oka S, Leon J, Tsuchimoto D, Sakumi K, Nakabeppu Y. PMID: 25310643; PMCID: PMC4216901.
      View in: PubMed   Mentions: 22  
    9. Altered expression of diabetes-related genes in Alzheimer's disease brains: the Hisayama study. Cereb Cortex. 2014 Sep; 24(9):2476-88. Hokama M, Oka S, Leon J, Ninomiya T, Honda H, Sasaki K, Iwaki T, Ohara T, Sasaki T, LaFerla FM, Kiyohara Y, Nakabeppu Y. PMID: 23595620; PMCID: PMC4128707.
      View in: PubMed   Mentions: 144     Fields:    Translation:HumansAnimals
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