Julio Leon Incio, PhD

TitlePostdoctoral Scholar
SchoolUCSF School of Medicine
Address675 Nelson Rising Lane
San Francisco CA 94158
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    Collapse Biography 
    Collapse Education and Training
    Kysuhu University, JAPANPhD04/2016Neuromolecular Biology and Functional Genomics
    Kyushu University, JAPANMSc04/2012Biochemistry and Cell Signaling
    National University of TrujilloBSc2007Biology
    Collapse Awards and Honors
    Kyushu University2015  - 2015Kyushu University Fund
    Ministry of Education and Science Japan2009  - 2016MOMBUKAGAKUSHO Scholarship
    National University of Trujillo2014  - 2014Antonio Samanamud Romero distinction award

    Collapse Overview 
    Collapse Overview
    I am scientist trained in functional genomics, molecular biology, and biochemistry. I am trying to better understand the underlying mechanisms of a resilient brain, with the aim of finding new strategies and therapeutic approaches to counter brain decline associated with aging and neurodegenerative diseases.

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Castillo E, Leon J, Mazzei G, Abolhassani N, Haruyama N, Saito T, Saido T, Hokama M, Iwaki T, Ohara T, Ninomiya T, Kiyohara Y, Sakumi K, LaFerla FM, Nakabeppu Y. Comparative profiling of cortical gene expression in Alzheimer's disease patients and mouse models demonstrates a link between amyloidosis and neuroinflammation. Sci Rep. 2017 Dec 19; 7(1):17762. PMID: 29259249.
      View in: PubMed
    2. Leon J, Moreno AJ, Garay BI, Chalkley RJ, Burlingame AL, Wang D, Dubal DB. Peripheral Elevation of a Klotho Fragment Enhances Brain Function and Resilience in Young, Aging, and a-Synuclein Transgenic Mice. Cell Rep. 2017 Aug 08; 20(6):1360-1371. PMID: 28793260.
      View in: PubMed
    3. Oka S, Leon J, Sakumi K, Ide T, Kang D, LaFerla FM, Nakabeppu Y. Human mitochondrial transcriptional factor A breaks the mitochondria-mediated vicious cycle in Alzheimer's disease. Sci Rep. 2016 Nov 29; 6:37889. PMID: 27897204.
      View in: PubMed
    4. Abolhassani N, Leon J, Sheng Z, Oka S, Hamasaki H, Iwaki T, Nakabeppu Y. Molecular pathophysiology of impaired glucose metabolism, mitochondrial dysfunction, and oxidative DNA damage in Alzheimer's disease brain. Mech Ageing Dev. 2017 Jan; 161(Pt A):95-104. PMID: 27233446.
      View in: PubMed
    5. Leon J, Sakumi K, Castillo E, Sheng Z, Oka S, Nakabeppu Y. 8-Oxoguanine accumulation in mitochondrial DNA causes mitochondrial dysfunction and impairs neuritogenesis in cultured adult mouse cortical neurons under oxidative conditions. Sci Rep. 2016 Feb 25; 6:22086. PMID: 26912170; PMCID: PMC4766534.
    6. Oka S, Leon J, Tsuchimoto D, Sakumi K, Nakabeppu Y. MUTYH, an adenine DNA glycosylase, mediates p53 tumor suppression via PARP-dependent cell death. Oncogenesis. 2014 Oct 13; 3:e121. PMID: 25310643; PMCID: PMC4216901.
    7. Hokama M, Oka S, Leon J, Ninomiya T, Honda H, Sasaki K, Iwaki T, Ohara T, Sasaki T, LaFerla FM, Kiyohara Y, Nakabeppu Y. Altered expression of diabetes-related genes in Alzheimer's disease brains: the Hisayama study. Cereb Cortex. 2014 Sep; 24(9):2476-88. PMID: 23595620; PMCID: PMC4128707.
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