Dena Dubal, MD, PhD

Title(s)Professor, Neurology
SchoolSchool of Medicine
Address675 Nelson Rising Lane, #212B
San Francisco CA 94158
Phone415-502-7237
ORCID ORCID Icon0000-0001-7504-4372 Additional info
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    Other Positions
    Title(s)UCSF Weill Institute for Neurosciences


    Collapse Biography 
    Collapse Education and Training
    UC Berkeley, Berkeley, CABA06/1996Anthropology and Molecular Neurosciences
    University of Kentucky, Lexington, KYMD, PhD6/2002Neuroscience and Physiology
    UCSF, San Francisco, CA2003Internal Medicine, Internship
    UCSF, San Francisco, CA07/2007Neurology
    UCSF, San Francisco, CA10/2009Behavioral Neurology Fellowship
    UCSF/Gladstone Institutes, San Francisco, CA10/2011Postdoctoral Fellowship
    Collapse Awards and Honors
    NIH/AFAR2009  - 2014Paul Beeson Award in Aging Research
    Organization for the Study of Sex Differences2010Elizabeth Young New Investigator Award
    UCSF2013David A. Coulter Endowed Chair in Aging and Neurodegenerative Disease
    Glenn Foundation for Medical Research2014Glenn Award for Research for Biological Mechanisms in Aging
    AFAR2015AFAR Award for Junior Faculty Research on Aging
    American Neurological Association2015The Grass Foundation: ANA Award in Neuroscience
    American Academy of Neurology2019Neuroendocrine Award

    Collapse Overview 
    Collapse Overview
    The goal of our research is to investigate mechanisms of longevity, resilience and neurodegenerative disease. Broadly we investigate how aging pathways can confer resilience to a brain and counter neurodegenerative diseases like Alzheimer’s. Using genetic mouse models, cell culture methods, and study of human populations using cutting-edge techniques, we study whether longevity-derived mechanisms can pave a path toward development of urgently needed therapies in aging and disease.

    To this end, we are unraveling mechanisms that underlie female longevity, studying sex chromosomal contributions to neurodegenerative disease, and investigating the longevity hormone klotho in the normal and diseased brain.
    Collapse In The News

    Collapse Research 
    Collapse Research Activities and Funding
    Sex Differences in Epigenetic Parent-of-X Origin and Alzheimer's Disease
    NIH RF1AG079176Aug 1, 2022 - Jul 31, 2025
    Role: Principal Investigator
    Sex-specific differences in cognitive and brain aging
    Simons Foundation 8112225SPINov 1, 2020 - Oct 31, 2025
    Role: PI
    Understanding how blood-borne factors improve the function of the aging brain
    Simons Foundation 8112225SPINov 1, 2020 - Oct 31, 2025
    Role: PI
    Mechanisms of X-Chromosome-dependent Sex Difference inAlzheimers Disease
    NIH RF1AG068325Sep 15, 2020 - Aug 31, 2024
    Role: Principal Investigator
    Klotho and Neurodegenerative Disease
    NIH R01NS092918Apr 1, 2016 - Mar 31, 2021
    Role: Principal Investigator
    Collagen VI: Novel Mechanisms and Functions in Alzheimer's Disease
    NIH K08AG034531Sep 1, 2009 - Aug 31, 2014
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications

    Collapse Featured Content 
    Collapse Twitter
    Collapse Featured Videos

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Tlr7 drives sex differences in age- and Alzheimer's disease-related demyelination. Science. 2024 Nov 29; 386(6725):eadk7844. Lopez-Lee C, Kodama L, Fan L, Zhu D, Zhu J, Wong MY, Ye P, Norman K, Foxe NR, Ijaz L, Yu F, Chen H, Carling GK, Torres ER, Kim RD, Dubal DB, Liddelow SA, Sinha SC, Luo W, Gan L. PMID: 39607927.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    2. Amyloid-β positivity is less prevalent in cognitively unimpaired KLOTHO KL-VS heterozygotes. J Alzheimers Dis. 2024 Nov 11; 13872877241289785. Cook N, Driscoll I, Gaitán JM, Glittenberg M, Betthauser TJ, Carlsson CM, Johnson SC, Asthana S, Zetterberg H, Blennow K, Kollmorgen G, Quijano-Rubio C, Dubal DB, Okonkwo OC. PMID: 39529379.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    3. β-Amyloid in Cognitively Unimpaired Individuals-Blame Mom? JAMA Neurol. 2024 Aug 01; 81(8):795-797. Dubal DB, Elser HC. PMID: 38885009.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    4. A second X chromosome improves cognition in aging male and female mice. bioRxiv. 2024 Jul 26. Marino F, Wang D, Merrihew GE, MacCoss MJ, Dubal DB. PMID: 39091744; PMCID: PMC11291180.
      View in: PubMed   Mentions:
    5. Sex and gender differences in cognitive resilience to aging and Alzheimer's disease. Alzheimers Dement. 2024 08; 20(8):5695-5719. Arenaza-Urquijo EM, Boyle R, Casaletto K, Anstey KJ, Vila-Castelar C, Colverson A, Palpatzis E, Eissman JM, Kheng Siang Ng T, Raghavan S, Akinci M, Vonk JMJ, Machado LS, Zanwar PP, Shrestha HL, Wagner M, Tamburin S, Sohrabi HR, Loi S, Bartrés-Faz D, Dubal DB, Vemuri P, Okonkwo O, Hohman TJ, Ewers M, Buckley RF, Reserve, Resilience and Protective Factors Professional Interest Area, Sex and Gender Professional I. PMID: 38967222; PMCID: PMC11350140.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimals
    6. KLOTHO KL-VS heterozygosity is associated with diminished age-related neuroinflammation, neurodegeneration, and synaptic dysfunction in older cognitively unimpaired adults. Alzheimers Dement. 2024 08; 20(8):5347-5356. Driscoll IF, Lose S, Ma Y, Bendlin BB, Gallagher C, Johnson SC, Asthana S, Hermann B, Sager MA, Blennow K, Zetterberg H, Carlsson C, Kollmorgen G, Quijano-Rubio C, Dubal D, Okonkwo OC. PMID: 39030746; PMCID: PMC11350058.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    7. Relationships between KLOTHO and APOE4-associated ß-amyloid and tau alterations across AD continuum. Alzheimer's & Dementia. 2023 Dec 25; 19(S12). Cook CN, Driscoll DI, Gallagher GC, Johnson JS, Asthana AS, Hermann HB, Sager SM, Blennow BK, Zetterberg ZH, Carlsson CC, Kollmorgen KG, Carboni CM, Wang WD, Dubal DD, Okonkwo OO. .
      View in: Publisher Site   Mentions:
    8. Klotho protein concentrations as a function of sex, APOE, family history or Alzheimer’s disease biomarker status in an at-risk cohort. Alzheimer's & Dementia. 2023 Dec 25; 19(S14). Driscoll DI, Betthauser BT, Gallagher GC, Hermann HB, Sager SM, Carlsson CC, Kollmorgen KG, Carboni CM, Wang WD, Blennow BK, Zetterberg ZH, Johnson JS, Asthana AS, Dubal DD, Okonkwo OO. .
      View in: Publisher Site   Mentions:
    9. Sex Chromosomes and Gonads Shape the Sex-Biased Transcriptomic Landscape in Tlr7-Mediated Demyelination During Aging. bioRxiv. 2023 Sep 21. Lopez-Lee C, Kodama L, Fan L, Wong MY, Foxe NR, Jiaz L, Yu F, Ye P, Zhu J, Norman K, Torres ER, Kim RD, Mousa GA, Dubal D, Liddelow S, Luo W, Gan L. PMID: 37781600; PMCID: PMC10541118.
      View in: PubMed   Mentions:
    10. Plasma phosphorylated tau-217 exhibits sex-specific prognostication of cognitive decline and brain atrophy in cognitively unimpaired adults. Alzheimers Dement. 2024 01; 20(1):376-387. Saloner R, VandeVrede L, Asken BM, Paolillo EW, Gontrum EQ, Wolf A, Lario-Lago A, Milà-Alomà M, Triana-Baltzer G, Kolb HC, Dubal DB, Rabinovici GD, Miller BL, Boxer AL, Casaletto KB, Kramer JH. PMID: 37639492; PMCID: PMC10843677.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    11. Platelet factors are induced by longevity factor klotho and enhance cognition in young and aging mice. Nat Aging. 2023 09; 3(9):1067-1078. Park C, Hahn O, Gupta S, Moreno AJ, Marino F, Kedir B, Wang D, Villeda SA, Wyss-Coray T, Dubal DB. PMID: 37587231; PMCID: PMC10501899.
      View in: PubMed   Mentions: 23     Fields:    Translation:Animals
    12. Associations between klotho and telomere biology in high stress caregivers. Aging (Albany NY). 2023 08 14; 15(15):7381-7396. Brown RL, Epel EE, Lin J, Dubal DB, Prather AA. PMID: 37580799; PMCID: PMC10457041.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    13. Longevity factor klotho enhances cognition in aged nonhuman primates. Nat Aging. 2023 08; 3(8):931-937. Castner SA, Gupta S, Wang D, Moreno AJ, Park C, Chen C, Poon Y, Groen A, Greenberg K, David N, Boone T, Baxter MG, Williams GV, Dubal DB. PMID: 37400721; PMCID: PMC10432271.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimals
    14. X Chromosome Factor Kdm6a Enhances Cognition Independent of Its Demethylase Function in the Aging XY Male Brain. J Gerontol A Biol Sci Med Sci. 2023 06 01; 78(6):938-943. Shaw CK, Abdulai-Saiku S, Marino F, Wang D, Davis EJ, Panning B, Dubal DB. PMID: 36617879; PMCID: PMC10235195.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    15. The mitochondrial unfolded protein response regulates hippocampal neural stem cell aging. Cell Metab. 2023 06 06; 35(6):996-1008.e7. Wang CL, Ohkubo R, Mu WC, Chen W, Fan JL, Song Z, Maruichi A, Sudmant PH, Pisco AO, Dubal DB, Ji N, Chen D. PMID: 37146607; PMCID: PMC10330239.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    16. Chapter 51 Sex differences in neurological and psychiatric diseases*. Neurobiology of Brain Disorders. 2023 Jan 1; 933-952. Arnold AA, Abdulai-Saiku AS, Chesselet CM, Dubal DD, Gold GS, McCullough ML, Shaw SC, Werling WD. .
      View in: Publisher Site   Mentions:
    17. X CHROMOSOME-DERIVED MECHANISMS OF SEX DIFFERENCES IN LIFESPAN AND BRAIN AGING. Innovation in Aging. 2022 Dec 20; 6(Supplement_1):165-165. Dubal DD. .
      View in: Publisher Site   Mentions:
    18. AD-associated CSF biomolecular changes are attenuated in KL-VS heterozygotes. Alzheimers Dement (Amst). 2022; 14(1):e12383. Driscoll I, Ma Y, Lose SR, Gallagher CL, Johnson SC, Asthana S, Hermann BP, Sager MA, Blennow K, Zetterberg H, Carlsson CM, Engelman CD, Dubal DB, Okonkwo OC. PMID: 36505396; PMCID: PMC9728548.
      View in: PubMed   Mentions: 3  
    19. Rare APOE Missense Variants-Can We Overcome APOE ε4 and Alzheimer Disease Risk? JAMA Neurol. 2022 07 01; 79(7):649-651. Rabinovici GD, Dubal DB. PMID: 35639398.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    20. An Integrated Analysis of Clinical, Genomic, and Imaging Features Reveals Predictors of Neurocognitive Outcomes in a Longitudinal Cohort of Pediatric Cancer Survivors, Enriched with CNS Tumors (Rad ART Pro). Front Oncol. 2022; 12:874317. Kline C, Stoller S, Byer L, Samuel D, Lupo JM, Morrison MA, Rauschecker AM, Nedelec P, Faig W, Dubal DB, Fullerton HJ, Mueller S. PMID: 35814456; PMCID: PMC9259981.
      View in: PubMed   Mentions: 2  
    21. KL1 Domain of Longevity Factor Klotho Mimics the Metabolome of Cognitive Stimulation and Enhances Cognition in Young and Aging Mice. J Neurosci. 2022 05 11; 42(19):4016-4025. Gupta S, Moreno AJ, Wang D, Leon J, Chen C, Hahn O, Poon Y, Greenberg K, David N, Wyss-Coray T, Raftery D, Promislow DEL, Dubal DB. PMID: 35428698; PMCID: PMC9097772.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    22. Deep phenotyping of Alzheimer's disease leveraging electronic medical records identifies sex-specific clinical associations. Nat Commun. 2022 02 03; 13(1):675. Tang AS, Oskotsky T, Havaldar S, Mantyh WG, Bicak M, Solsberg CW, Woldemariam S, Zeng B, Hu Z, Oskotsky B, Dubal D, Allen IE, Glicksberg BS, Sirota M. PMID: 35115528; PMCID: PMC8814236.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    23. KIBRA, MTNR1B, and FKBP5 genotypes are associated with decreased odds of incident delirium in elderly post-surgical patients. Sci Rep. 2022 Jan 11; 12(1):556. Terrelonge M, LaHue SC, Tang C, Movsesyan I, Pullinger CR, Dubal DB, Leung J, Douglas VC. PMID: 35017578; PMCID: PMC8752781.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    24. Circulating Klotho Is Higher in Cerebrospinal Fluid than Serum and Elevated Among KLOTHO Heterozygotes in a Cohort with Risk for Alzheimer's Disease. J Alzheimers Dis. 2022; 90(4):1557-1569. Gaitán JM, Asthana S, Carlsson CM, Engelman CD, Johnson SC, Sager MA, Wang D, Dubal DB, Okonkwo OC. PMID: 36314202; PMCID: PMC10139824.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    25. Female resilience in brain aging. Innovation in Aging. 2021 Dec 17; 5(Suppl 1):198-198. Dubal DD. .
      View in: Publisher Site   Mentions:
    26. Sex-Stratified Single-Cell RNA-Seq Analysis Identifies Sex-Specific and Cell Type-Specific Transcriptional Responses in Alzheimer's Disease Across Two Brain Regions. Mol Neurobiol. 2022 Jan; 59(1):276-293. Belonwu SA, Li Y, Bunis D, Rao AA, Solsberg CW, Tang A, Fragiadakis GK, Dubal DB, Oskotsky T, Sirota M. PMID: 34669146; PMCID: PMC8786804.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    27. Sex-Specific Association of the X Chromosome With Cognitive Change and Tau Pathology in Aging and Alzheimer Disease. JAMA Neurol. 2021 10 01; 78(10):1249-1254. Davis EJ, Solsberg CW, White CC, Miñones-Moyano E, Sirota M, Chibnik L, Bennett DA, De Jager PL, Yokoyama JS, Dubal DB. PMID: 34424272; PMCID: PMC8383157.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    28. Effects of Aerobic Exercise Training on Systemic Biomarkers and Cognition in Late Middle-Aged Adults at Risk for Alzheimer's Disease. Front Endocrinol (Lausanne). 2021; 12:660181. Gaitán JM, Moon HY, Stremlau M, Dubal DB, Cook DB, Okonkwo OC, van Praag H. PMID: 34093436; PMCID: PMC8173166.
      View in: PubMed   Mentions: 47     Fields:    Translation:Humans
    29. Sugar sweetened beverage consumption is positively associated with Klotho levels at two years of age in LatinX youth. BMC Nutr. 2021 Apr 23; 7(1):22. Villagomez S, Dubal DB, Hawkins J, Wang D, Wojcicki JM. PMID: 33888157; PMCID: PMC8063295.
      View in: PubMed   Mentions:
    30. Age-Related Tau Burden and Cognitive Deficits Are Attenuated in KLOTHO KL-VS Heterozygotes. J Alzheimers Dis. 2021; 79(3):1297-1305. Driscoll I, Ma Y, Gallagher CL, Johnson SC, Asthana S, Hermann BP, Sager MA, Blennow K, Zetterberg H, Carlsson CM, Engelman CD, Dubal DB, Okonkwo OC. PMID: 33427737; PMCID: PMC9472657.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    31. Age-Related Tau Burden and Cognitive Deficits Are Attenuated in KLOTHO KL-VS Heterozygotes. J Alzheimers Dis. 2021; 82(3):1369-1370. Driscoll I, Ma Y, Gallagher CL, Johnson SC, Asthana S, Hermann BP, Sager MA, Blennow K, Zetterberg H, Carlsson CM, Engelman CD, Dubal DB, Okonkwo OC. PMID: 34250957.
      View in: PubMed   Mentions: 4     Fields:    
    32. QOL-53. GENOME ASSOCIATIONS WITH NEUROCOGNITIVE OUTCOMES, CEREBRAL MICROBLEEDS (CMBS), AND BRAIN VOLUME AND WHITE MATTER (WM) CHANGES IN PEDIATRIC BRAIN TUMOR SURVIVORS. Neuro-Oncology. 2020 Dec 4; 22(Suppl 3):iii440-iii440. Kline KC, Stoller SS, Byer BL, Edwards EC, Prasad PR, Torkildson TJ, Gauvain GK, Samuel SD, Lupo LJ, Morrison MM, Tong TE, Savchuk SS, Valencia VC, Rauschecker RA, Rudie RJ, Hoffman HT, Dubal DD, Fullerton FH, Mueller MS. .
      View in: Publisher Site   Mentions:
    33. NCOG-71. GENOME ASSOCIATIONS WITH NEUROCOGNITIVE OUTCOMES, CEREBRAL MICROBLEEDS (CMBS), AND BRAIN VOLUME AND WHITE MATTER (WM) CHANGES IN PEDIATRIC BRAIN TUMOR SURVIVORS. Neuro-Oncology. 2020 Nov 9; 22(Supplement_2):ii145-ii145. Kline KC, Stoller SS, Byer BL, Edwards EC, Prasad PR, Torkildson TJ, Gauvain GK, Samuel SD, Lupo LJ, Morrison MM, Tong TE, Savchuk SS, Valencia VC, Rauschecker RA, Rudie RJ, Hoffmann HT, Dubal DD, Fullerton FH, Mueller MS. .
      View in: Publisher Site   Mentions:
    34. A second X chromosome contributes to resilience in a mouse model of Alzheimer's disease. Sci Transl Med. 2020 08 26; 12(558). Davis EJ, Broestl L, Abdulai-Saiku S, Worden K, Bonham LW, Miñones-Moyano E, Moreno AJ, Wang D, Chang K, Williams G, Garay BI, Lobach I, Devidze N, Kim D, Anderson-Bergman C, Yu GQ, White CC, Harris JA, Miller BL, Bennett DA, Arnold AP, De Jager PL, Palop JJ, Panning B, Yokoyama JS, Mucke L, Dubal DB. PMID: 32848093; PMCID: PMC8409261.
      View in: PubMed   Mentions: 74     Fields:    Translation:AnimalsCells
    35. Longevity Gene KLOTHO and Alzheimer Disease-A Better Fate for Individuals Who Carry APOE ε4. JAMA Neurol. 2020 07 01; 77(7):798-800. Dubal DB, Yokoyama JS. PMID: 32282012.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    36. 4329 Investigating the role of Klotho in neurocognitive outcomes, brain volumes, and white matter changes in pediatric brain tumor survivors. Journal of Clinical and Translational Science. 2020 Jun 1; 4(s1):98-98. Edwards EC, Stoller SS, Savchuk SS, Valencia VC, Tong TL, Rauschecker RA, Dubal DD, Kline KC, Mueller MS. .
      View in: Publisher Site   Mentions:
    37. Sexual dimorphism of physical activity on cognitive aging: Role of immune functioning. Brain Behav Immun. 2020 08; 88:699-710. Casaletto KB, Lindbergh C, Memel M, Staffaroni A, Elahi F, Weiner-Light S, You M, Fonseca C, Karydas A, Jacobs E, Dubal DB, Yaffe K, Kramer JH. PMID: 32387511; PMCID: PMC7416443.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    38. Melatonin Receptor-1B Genotype, KIBRA Genotype, and Possibly a-Klotho Plasma Level in Women are Associated with Incident Delirium in Elderly Post-surgical Patients (963). Neurology. 2020 Apr 14; 94(15_supplement). Terrelonge TM, Wang WD, Tang TC, Movseyan MI, Pullinger PC, Leung LJ, Dubal DD, Douglas DV. .
      View in: Publisher Site   Mentions:
    39. Best of JAMA Neurology 2019: Research That Drives Practice. JAMA Neurol. 2020 03 01; 77(3):293-294. Kamel H, Dubal DB. PMID: 31904807.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    40. Sex difference in Alzheimer's disease: An updated, balanced and emerging perspective on differing vulnerabilities. Handb Clin Neurol. 2020; 175:261-273. Dubal DB. PMID: 33008530.
      View in: PubMed   Mentions: 40     Fields:    Translation:Humans
    41. Pathways to brain resilience. Nat Med. 2019 07; 25(7):1027. Dubal DB. PMID: 31270494.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    42. Neural-Derived Extracellular Vesicles in Clinical Trials: Message in a Bottle. JAMA Neurol. 2019 04 01; 76(4):402-404. Dubal DB, Pleasure SJ. PMID: 30640380.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    43. KLOTHO heterozygosity attenuates APOE4-related amyloid burden in preclinical AD. Neurology. 2019 Apr 16; 92(16):e1878-e1889. Erickson CM, Schultz SA, Oh JM, Darst BF, Ma Y, Norton D, Betthauser T, Gallagher CL, Carlsson CM, Bendlin BB, Asthana S, Hermann BP, Sager MA, Blennow K, Zetterberg H, Engelman CD, Christian BT, Johnson SC, Dubal DB, Okonkwo OC. PMID: 30867273; PMCID: PMC6550504.
      View in: PubMed   Mentions: 27     Fields:    Translation:Humans
    44. Cognitive aging is not created equally: differentiating unique cognitive phenotypes in "normal" adults. Neurobiol Aging. 2019 05; 77:13-19. Casaletto KB, Elahi FM, Staffaroni AM, Walters S, Contreras WR, Wolf A, Dubal D, Miller B, Yaffe K, Kramer JH. PMID: 30772736; PMCID: PMC6486874.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    45. Female XX sex chromosomes increase survival and extend lifespan in aging mice. Aging Cell. 2019 02; 18(1):e12871. Davis EJ, Lobach I, Dubal DB. PMID: 30560587; PMCID: PMC6351820.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    46. Ovarian Cycle Stages Modulate Alzheimer-Related Cognitive and Brain Network Alterations in Female Mice. eNeuro. 2018 Nov-Dec; 5(6). Broestl L, Worden K, Moreno AJ, Davis EJ, Wang D, Garay B, Singh T, Verret L, Palop JJ, Dubal DB. PMID: 30627643; PMCID: PMC6325547.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimals
    47. QOL-47. ApoE4 AS A GENETIC PREDICTOR FOR NEUROCOGNITIVE OUTCOMES IN PEDIATRIC BRAIN TUMOR SURVIVORS. Neuro-Oncology. 2018 Jun 22; 20(suppl_2):i167-i167. Kline KC, Felton FE, Byer BL, Stoller SS, Torkildson TJ, Gauvain GK, Samuel SD, Tong TE, Liu LJ, Fullerton FH, Dubal DD, Mueller MS. .
      View in: Publisher Site   Mentions:
    48. The Way of Tau: Secretion and Synaptic Dysfunction. Trends Mol Med. 2018 07; 24(7):595-597. Dubal DB. PMID: 29807705; PMCID: PMC6771005.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    49. Cord blood klotho levels are inversely associated with leptin in healthy Latino neonates at risk for obesity. J Pediatr Endocrinol Metab. 2018 Apr 25; 31(5):515-520. Wojcicki JM, Prather AA, Epel E, Wang D, Dubal DB. PMID: 29648999; PMCID: PMC6770989.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    50. Apolipoprotein E ε4 and Risk Factors for Alzheimer Disease-Let's Talk About Sex. JAMA Neurol. 2017 10 01; 74(10):1167-1168. Dubal DB, Rogine C. PMID: 28846761.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    51. Peripheral Elevation of a Klotho Fragment Enhances Brain Function and Resilience in Young, Aging, and α-Synuclein Transgenic Mice. Cell Rep. 2017 08 08; 20(6):1360-1371. Leon J, Moreno AJ, Garay BI, Chalkley RJ, Burlingame AL, Wang D, Dubal DB. PMID: 28793260; PMCID: PMC5816951.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    52. BDNF Val66Met predicts cognitive decline in the Wisconsin Registry for Alzheimer's Prevention. Neurology. 2017 May 30; 88(22):2098-2106. Boots EA, Schultz SA, Clark LR, Racine AM, Darst BF, Koscik RL, Carlsson CM, Gallagher CL, Hogan KJ, Bendlin BB, Asthana S, Sager MA, Hermann BP, Christian BT, Dubal DB, Engelman CD, Johnson SC, Okonkwo OC. PMID: 28468845; PMCID: PMC5447398.
      View in: PubMed   Mentions: 33     Fields:    Translation:Humans
    53. Systemic klotho is associated with KLOTHO variation and predicts intrinsic cortical connectivity in healthy human aging. Brain Imaging Behav. 2017 04; 11(2):391-400. Yokoyama JS, Marx G, Brown JA, Bonham LW, Wang D, Coppola G, Seeley WW, Rosen HJ, Miller BL, Kramer JH, Dubal DB. PMID: 27714549; PMCID: PMC5382127.
      View in: PubMed   Mentions: 30     Fields:    Translation:Humans
    54. Sex biology contributions to vulnerability to Alzheimer's disease: A think tank convened by the Women's Alzheimer's Research Initiative. Alzheimers Dement. 2016 11; 12(11):1186-1196. Snyder HM, Asthana S, Bain L, Brinton R, Craft S, Dubal DB, Espeland MA, Gatz M, Mielke MM, Raber J, Rapp PR, Yaffe K, Carrillo MC. PMID: 27692800; PMCID: PMC10341380.
      View in: PubMed   Mentions: 118     Fields:    Translation:Humans
    55. LONGEVITY GENE KLOTHO ALTERS APOE4-RELATED CORTICAL THINNING: FINDINGS FROM THE WISCONSIN REGISTRY FOR ALZHEIMER’S PREVENTION. Alzheimer's & Dementia. 2016 Jul 1; 12(7):p56. Schultz SS, Boots BE, Oh OJ, Darst DB, Koscik KR, Gallagher GC, Carlsson CC, Rowley RH, Bendlin BB, Asthana AS, Sager SM, Hogan HK, Hermann HB, Engelman EC, Johnson JS, Dubal DD, Okonkwo OO. .
      View in: Publisher Site   Mentions:
    56. LONGEVITY GENE KLOTHO ALTERS APOE4-RELATED CORTICAL THINNING: FINDINGS FROM THE WISCONSIN REGISTRY FOR ALZHEIMER’S PREVENTION. Alzheimer's & Dementia. 2016 Jul 1; 12(7):p377-p378. Schultz SS, Boots BE, Oh OJ, Darst DB, Koscik KR, Gallagher GC, Carlsson CC, Rowley RH, Bendlin BB, Asthana AS, Sager SM, Hogan HK, Hermann HB, Engelman EC, Johnson JS, Dubal DD, Okonkwo OO. .
      View in: Publisher Site   Mentions:
    57. Network dysfunction in α-synuclein transgenic mice and human Lewy body dementia. Ann Clin Transl Neurol. 2015 11; 2(11):1012-28. Morris M, Sanchez PE, Verret L, Beagle AJ, Guo W, Dubal D, Ranasinghe KG, Koyama A, Ho K, Yu GQ, Vossel KA, Mucke L. PMID: 26732627; PMCID: PMC4693622.
      View in: PubMed   Mentions: 30     Fields:    
    58. Longevity factor klotho and chronic psychological stress. Transl Psychiatry. 2015 Jun 16; 5:e585. Prather AA, Epel ES, Arenander J, Broestl L, Garay BI, Wang D, Dubal DB. PMID: 26080320; PMCID: PMC4490291.
      View in: PubMed   Mentions: 36     Fields:    Translation:Humans
    59. Variation in Longevity Gene KLOTHO is Associated with Greater Cortical Volumes in Aging (S41.002). Neurology. 2015 Apr 6; 84(14_supplement). Yokoyama YJ, Sturm SV, Bonham BL, Klein KE, Arfanakis AK, Yu YL, Coppola CG, Kramer KJ, Bennett BD, Miller MB, Dubal DD. .
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    60. Life extension factor klotho prevents mortality and enhances cognition in hAPP transgenic mice. J Neurosci. 2015 Feb 11; 35(6):2358-71. Dubal DB, Zhu L, Sanchez PE, Worden K, Broestl L, Johnson E, Ho K, Yu GQ, Kim D, Betourne A, Kuro-O M, Masliah E, Abraham CR, Mucke L. PMID: 25673831; PMCID: PMC4323521.
      View in: PubMed   Mentions: 103     Fields:    Translation:HumansAnimalsCells
    61. Variation in longevity gene KLOTHO is associated with greater cortical volumes. Ann Clin Transl Neurol. 2015 Mar; 2(3):215-30. Yokoyama JS, Sturm VE, Bonham LW, Klein E, Arfanakis K, Yu L, Coppola G, Kramer JH, Bennett DA, Miller BL, Dubal DB. PMID: 25815349; PMCID: PMC4369272.
      View in: PubMed   Mentions: 49     Fields:    
    62. Astrocytic adenosine receptor A2A and Gs-coupled signaling regulate memory. Nat Neurosci. 2015 Mar; 18(3):423-34. Orr AG, Hsiao EC, Wang MM, Ho K, Kim DH, Wang X, Guo W, Kang J, Yu GQ, Adame A, Devidze N, Dubal DB, Masliah E, Conklin BR, Mucke L. PMID: 25622143; PMCID: PMC4340760.
      View in: PubMed   Mentions: 127     Fields:    Translation:HumansAnimalsCells
    63. Life extension factor klotho enhances cognition. Cell Rep. 2014 May 22; 7(4):1065-76. Dubal DB, Yokoyama JS, Zhu L, Broestl L, Worden K, Wang D, Sturm VE, Kim D, Klein E, Yu GQ, Ho K, Eilertson KE, Yu L, Kuro-o M, De Jager PL, Coppola G, Small GW, Bennett DA, Kramer JH, Abraham CR, Miller BL, Mucke L. PMID: 24813892; PMCID: PMC4176932.
      View in: PubMed   Mentions: 146     Fields:    Translation:HumansAnimalsCells
    64. Reversible suppression of electrocerebral activity. Neurohospitalist. 2013 Oct; 3(4):229-30. Broestl L, Cornes S, Dubal DB. PMID: 24198906; PMCID: PMC3810832.
      View in: PubMed   Mentions:
    65. Sex and gonadal hormones in mouse models of Alzheimer's disease: what is relevant to the human condition? Biol Sex Differ. 2012 Nov 05; 3(1):24. Dubal DB, Broestl L, Worden K. PMID: 23126652; PMCID: PMC3524653.
      View in: PubMed   Mentions: 26     Fields:    
    66. Human P301L-mutant tau expression in mouse entorhinal-hippocampal network causes tau aggregation and presynaptic pathology but no cognitive deficits. PLoS One. 2012; 7(9):e45881. Harris JA, Koyama A, Maeda S, Ho K, Devidze N, Dubal DB, Yu GQ, Masliah E, Mucke L. PMID: 23029293; PMCID: PMC3454317.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansAnimalsCells
    67. T-cell lymphoproliferative disorder following mycophenolate treatment for myasthenia gravis. Muscle Nerve. 2009 Jun; 39(6):849-50. Dubal DB, Mueller S, Ruben BS, Engstrom JW, Josephson SA. PMID: 19358236.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    68. Collagen VI protects neurons against Abeta toxicity. Nat Neurosci. 2009 Feb; 12(2):119-21. Cheng JS, Dubal DB, Kim DH, Legleiter J, Cheng IH, Yu GQ, Tesseur I, Wyss-Coray T, Bonaldo P, Mucke L. PMID: 19122666; PMCID: PMC2812922.
      View in: PubMed   Mentions: 73     Fields:    Translation:HumansAnimalsCells
    69. P1-465: Role of collagen VI in Alzheimer's disease: Potential mechanisms of protection. Alzheimer's & Dementia. 2008 Jul 1; 4(4):t356. Dubal DD, Cheng CJ, Legleiter LJ, Wilkins WS, Bonaldo BP, Yu YG, Mucke ML. .
      View in: Publisher Site   Mentions:
    70. A case of paraneoplastic myelopathy associated with the neuromyelitis optica antibody. Nat Clin Pract Neurol. 2008 May; 4(5):284-8. Mueller S, Dubal DB, Josephson SA. PMID: 18317500.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    71. Differential modulation of estrogen receptors (ERs) in ischemic brain injury: a role for ERalpha in estradiol-mediated protection against delayed cell death. Endocrinology. 2006 Jun; 147(6):3076-84. Dubal DB, Rau SW, Shughrue PJ, Zhu H, Yu J, Cashion AB, Suzuki S, Gerhold LM, Bottner MB, Dubal SB, Merchanthaler I, Kindy MS, Wise PM. PMID: 16527848.
      View in: PubMed   Mentions: 77     Fields:    Translation:AnimalsCells
    72. Stroke injury in rats causes an increase in activin A gene expression which is unaffected by oestradiol treatment. J Neuroendocrinol. 2006 Feb; 18(2):97-103. Böttner M, Dubal DB, Rau SW, Suzuki S, Wise PM. PMID: 16420278.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    73. Are estrogens protective or risk factors in brain injury and neurodegeneration? Reevaluation after the Women's health initiative. Endocr Rev. 2005 May; 26(3):308-12. Wise PM, Dubal DB, Rau SW, Brown CM, Suzuki S. PMID: 15851820.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimals
    74. Are Estrogens Protective or Risk Factors in the Brain? Insights Derived From Animal Models. Endocrine Aspects of Successful Aging: Genes, Hormones and Lifestyles. 2004 Jan 1; 165-173. Wise WP, Dubal DD. .
      View in: Publisher Site   Mentions:
    75. Mechanisms of sex-based neuropathologies. Principles of Sex-based Differences in Physiology. 2004 Jan 1; 34:281-294. Wise WP, Dubal DD, Rau RS, Cashion CA. .
      View in: Publisher Site   Mentions:
    76. Activin gene expression increases after stroke injury: Modulation by estradiol. Experimental and Clinical Endocrinology & Diabetes. 2004 Jan 1; 112(S 1). Böttner BM, Dubal DD, Rau RS, Wise WP. .
      View in: Publisher Site   Mentions:
    77. Estradiol attenuates programmed cell death after stroke-like injury. J Neurosci. 2003 Dec 10; 23(36):11420-6. Rau SW, Dubal DB, Böttner M, Gerhold LM, Wise PM. PMID: 14673006; PMCID: PMC6740516.
      View in: PubMed   Mentions: 51     Fields:    Translation:Animals
    78. Estradiol differentially regulates c-Fos after focal cerebral ischemia. J Neurosci. 2003 Nov 19; 23(33):10487-94. Rau SW, Dubal DB, Böttner M, Wise PM. PMID: 14627632; PMCID: PMC6740922.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    79. Ms Jones: reflections on aging, illness, and medicine. Fam Med. 2003 Mar; 35(3):165-6. Dubal D. PMID: 12670107.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    80. Estrogen and neuroprotection: from clinical observations to molecular mechanisms. Dialogues Clin Neurosci. 2002 Jun; 4(2):149-61. Dubal DB, Wise PM. PMID: 22034440; PMCID: PMC3181675.
      View in: PubMed   Mentions: 13     Fields:    
    81. Neuroendocrine modulation and repercussions of female reproductive aging. Recent Prog Horm Res. 2002; 57:235-56. Wise PM, Smith MJ, Dubal DB, Wilson ME, Rau SW, Cashion AB, Böttner M, Rosewell KL. PMID: 12017546.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimals
    82. Estradiol is a protective factor in the adult and aging brain: understanding of mechanisms derived from in vivo and in vitro studies. Brain Res Brain Res Rev. 2001 Nov; 37(1-3):313-9. Wise PM, Dubal DB, Wilson ME, Rau SW, Böttner M, Rosewell KL. PMID: 11744096.
      View in: PubMed   Mentions: 58     Fields:    Translation:AnimalsCells
    83. In Vitro and In Vivo Approaches to the Study of the Neuroprotective Actions of Estradiol. Neuroplasticity, Development, and Steroid Hormone Action. 2001 Jul 30. Wise WP, Wilson WM, Dubal DD, Rau RS. .
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    84. Minireview: neuroprotective effects of estrogen-new insights into mechanisms of action. Endocrinology. 2001 Mar; 142(3):969-73. Wise PM, Dubal DB, Wilson ME, Rau SW, Böttner M. PMID: 11181507.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansAnimals
    85. Minireview: Neuroprotective Effects of Estrogen—New Insights into Mechanisms of Action. Endocrinology. 2001 Mar 1; 142(3):969-973. Wise WP, Dubal DD, Wilson WM, Rau RS, Bo¨ttner BM. .
      View in: Publisher Site   Mentions:
    86. Estrogen receptor a, not ß, is a critical link in estradiol-mediated protection against brain injury. Proceedings of the National Academy of Sciences. 2001 Feb 13; 98(4):1952-1957. Dubal DD, Zhu ZH, Yu YJ, Rau RS, Shughrue SP, Merchenthaler MI, Kindy KM, Wise WP. .
      View in: Publisher Site   Mentions:
    87. Estrogen receptor alpha, not beta, is a critical link in estradiol-mediated protection against brain injury. Proc Natl Acad Sci U S A. 2001 Feb 13; 98(4):1952-7. Dubal DB, Zhu H, Yu J, Rau SW, Shughrue PJ, Merchenthaler I, Kindy MS, Wise PM. PMID: 11172057; PMCID: PMC29363.
      View in: PubMed   Mentions: 200     Fields:    Translation:Animals
    88. Estrogens: trophic and protective factors in the adult brain. Front Neuroendocrinol. 2001 Jan; 22(1):33-66. Wise PM, Dubal DB, Wilson ME, Rau SW, Liu Y. PMID: 11141318.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansAnimalsCells
    89. Neuroprotective effects of estradiol in middle-aged female rats. Endocrinology. 2001 Jan; 142(1):43-8. Dubal DB, Wise PM. PMID: 11145565.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansAnimals
    90. Neuroprotective Effects of Estradiol in Middle-Aged Female Rats**Supported in part by NIH Grant AG-02224 (to P.M.W.), NIH Predoctoral fellowship T32-AG-00242 (to D.B.D.), Merck/American Federation for Aging Research Scholarship (to D.B.D.), and Glenn Foundation/American Federation for Aging Research Scholarship (to D.B.D.). Some of these data were presented in a minireview that summarized a symposium contribution by PMW (1 ). Endocrinology. 2001 Jan 1; 142(1):43-48. Dubal DD, Wise WP. .
      View in: Publisher Site   Mentions:
    91. Estradiol protects against ischemic brain injury in middle-aged rats. Biol Reprod. 2000 Oct; 63(4):982-5. Wise PM, Dubal DB. PMID: 10993817.
      View in: PubMed   Mentions: 30     Fields:    Translation:Animals
    92. Estradiol protects against injury-induced cell death in cortical explant cultures: a role for estrogen receptors. Brain Res. 2000 Aug 11; 873(2):235-42. Wilson ME, Dubal DB, Wise PM. PMID: 10930549.
      View in: PubMed   Mentions: 35     Fields:    Translation:Animals
    93. Estradiol is a neuroprotective factor in in vivo and in vitro models of brain injury. J Neurocytol. 2000 May-Jun; 29(5-6):401-10. Wise PM, Dubal DB, Wilson ME, Rau SW. PMID: 11424956.
      View in: PubMed   Mentions: 16     Fields:    Translation:Animals
    94. Neuroprotective actions of estradiol in the adult and aging brain: Potential mechanisms of action. Neurobiology of Aging. 2000 May 1; 21:212-213. Wise WP, Dubal DD, Wilson WM, Rau RS. .
      View in: Publisher Site   Mentions:
    95. Estradiol: a protective and trophic factor in the brain. J Alzheimers Dis. 1999 Nov; 1(4-5):265-74. Dubal DB, Wilson ME, Wise PM. PMID: 12214124.
      View in: PubMed   Mentions: 8     Fields:    
    96. Estradiol modulates bcl-2 in cerebral ischemia: a potential role for estrogen receptors. J Neurosci. 1999 Aug 01; 19(15):6385-93. Dubal DB, Shughrue PJ, Wilson ME, Merchenthaler I, Wise PM. PMID: 10414967; PMCID: PMC6782804.
      View in: PubMed   Mentions: 127     Fields:    Translation:Animals
    97. Neuroendocrine influences and repercussions of the menopause. Endocr Rev. 1999 Jun; 20(3):243-8. Wise PM, Smith MJ, Dubal DB, Wilson ME, Krajnak KM, Rosewell KL. PMID: 10368769.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    98. Estradiol protects against ischemic injury. J Cereb Blood Flow Metab. 1998 Nov; 18(11):1253-8. Dubal DB, Kashon ML, Pettigrew LC, Ren JM, Finklestein SP, Rau SW, Wise PM. PMID: 9809515.
      View in: PubMed   Mentions: 147     Fields:    Translation:HumansAnimals
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