Loading...

Stephen Kahl, PhD

TitleProfessor
SchoolUCSF School of Pharmacy
DepartmentPharmaceutical Chemistry
Address513 Parnassus Avenue
San Francisco CA 94117
Phone415-476-4684
vCardDownload vCard

    Collapse Research 
    Collapse Research Activities and Funding
    In vivo feasibility of a peripheral nerve imaging agent
    NIH/NCI R43CA180745Sep 1, 2013 - Feb 28, 2014
    Role: Principal Investigator
    Program for Development of BNCT Agents
    NIH/NCI R01CA082478Mar 1, 2000 - Jan 31, 2012
    Role: Principal Investigator
    DESIGN/SYNTHESIS OF BORONATED TUMOR-SEEKING MACROCYCLIC
    NIH/NCI R01CA053901Sep 18, 1991 - Jul 31, 1996
    Role: Principal Investigator
    BORONATED LIPOPROTEIN SITE SPECIFIC RADIOCHEMOTHERAPY
    NIH/NCI R01CA041487Jun 1, 1986 - May 31, 1990
    Role: Principal Investigator
    BORONATED TUMOR-SEEKING PORPHYRINS--SYNTHESIS &TESTING
    NIH/NCI R01CA037961Jul 1, 1985 - Mar 31, 1997
    Role: Principal Investigator
    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Koo MS, Ozawa T, Santos RA, Lamborn KR, Bollen AW, Deen DF, Kahl SB. Synthesis and comparative toxicology of a series of polyhedral borane anion-substituted tetraphenyl porphyrins. J Med Chem. 2007 Feb 22; 50(4):820-7. PMID: 17253677.
      View in: PubMed
    2. Dozzo P, Kasar RA, Kahl SB. Simple, high-yield methods for the synthesis of aldehydes directly from o-, m-, and p-carborane and their further conversions. Inorg Chem. 2005 Oct 31; 44(22):8053-7. PMID: 16241155.
      View in: PubMed
    3. Ozawa T, Afzal J, Lamborn KR, Bollen AW, Bauer WF, Koo MS, Kahl SB, Deen DF. Toxicity, biodistribution, and convection-enhanced delivery of the boronated porphyrin BOPP in the 9L intracerebral rat glioma model. Int J Radiat Oncol Biol Phys. 2005 Sep 1; 63(1):247-52. PMID: 16111595.
      View in: PubMed
    4. Dagrosa MA, Viaggi M, Rebagliati RJ, Batistoni D, Kahl SB, Juvenal GJ, Pisarev MA. Biodistribution of boron compounds in an animal model of human undifferentiated thyroid cancer for boron neutron capture therapy. Mol Pharm. 2005 Mar-Apr; 2(2):151-6. PMID: 15804189.
      View in: PubMed
    5. Dozzo P, Koo MS, Berger S, Forte TM, Kahl SB. Synthesis, characterization, and plasma lipoprotein association of a nucleus-targeted boronated porphyrin. J Med Chem. 2005 Jan 27; 48(2):357-9. PMID: 15658849.
      View in: PubMed
    6. Viaggi M, Dagrosa MA, Longhino J, Blaumann H, Calzetta O, Kahl S, Juvenal GJ, Pisarev MA. Boron neutron capture therapy for undifferentiated thyroid carcinoma: preliminary results with the combined use of BPA and BOPP. Appl Radiat Isot. 2004 Nov; 61(5):905-9. PMID: 15308166.
      View in: PubMed
    7. Ozawa T, Santos RA, Lamborn KR, Bauer WF, Koo MS, Kahl SB, Deen DF. In vivo evaluation of the boronated porphyrin TABP-1 in U-87 MG intracerebral human glioblastoma xenografts. Mol Pharm. 2004 Sep-Oct; 1(5):368-74. PMID: 16026007.
      View in: PubMed
    8. Rosenthal MA, Kavar B, Hill JS, Morgan DJ, Nation RL, Stylli SS, Basser RL, Uren S, Geldard H, Green MD, Kahl S, Kaye AH. Phase I and pharmacokinetic study of photodynamic therapy for high-grade gliomas using a novel boronated porphyrin. J Clin Oncol. 2001 Jan 15; 19(2):519-24. PMID: 11208846.
      View in: PubMed
    9. Tibbitts J, Sambol NC, Fike JR, Bauer WF, Kahl SB. Plasma pharmacokinetics and tissue biodistribution of boron following administration of a boronated porphyrin in dogs. J Pharm Sci. 2000 Apr; 89(4):469-77. PMID: 10737908.
      View in: PubMed
    10. Callahan DE, Forte TM, Afzal SM, Deen DF, Kahl S, Bjornstad KA, Bauer WF, Blakely EA. Boronated protoporphyrin (BOPP): localization in lysosomes of the human glioma cell line SF-767 with uptake modulated by lipoprotein levels. Int J Radiat Oncol Biol Phys. 1999 Oct 1; 45(3):761-71. PMID: 10524433.
      View in: PubMed
    11. Zhou R, Balasubramanian SV, Kahl S, Straubinger RM. Biopharmaceutics of boronated radiosensitizers: liposomal formulation of MnBOPP (manganese chelate of 2,4-(alpha, beta-dihydroxyethyl) deuterioporphyrin IX) and comparative toxicity in mice. J Pharm Sci. 1999 Sep; 88(9):912-7. PMID: 10479353.
      View in: PubMed
    12. Kasar RA, Knudsen GM, Kahl SB. Synthesis of 3-Amino-1-carboxy-o-carborane and an Improved, General Method for the Synthesis of All Three C-Amino-C-carboxycarboranes. Inorg Chem. 1999 Jun 14; 38(12):2936-2940. PMID: 11671041.
      View in: PubMed
    13. Tibbitts J, Fike JR, Lamborn KR, Bollen AW, Kahl SB. Toxicology of a boronated porphyrin in dogs. Photochem Photobiol. 1999 May; 69(5):587-94. PMID: 10333766.
      View in: PubMed
    14. Spizzirri PG, Hill JS, Kahl S, Ghiggino KP. Photophysics and intracellular distribution of a boronated porphyrin phototherapeutic agent. Photochem Photobiol. 1996 Dec; 64(6):975-83. PMID: 8972641.
      View in: PubMed
    15. Munday AD, Sriratana A, Hill JS, Kahl S, Nagley P. Mitochondria are the functional intracellular target for a photosensitizing boronated porphyrin. Biochim Biophys Acta. 1996 Mar 27; 1311(1):1-4. PMID: 8603096.
      View in: PubMed
    16. Laster BH, Shani G, Kahl S, Warkentien L. The biological effects of Auger electrons compared to alpha-particles and Li ions. Acta Oncol. 1996; 35(7):917-23. PMID: 9004772.
      View in: PubMed
    17. Hill JS, Kahl S, Stylli SS, Nakamura Y, Koo MS, Kaye AH. Selective tumor kill of cerebral glioma by photodynamic therapy using a boronated porphyrin photosensitizer. Proc Natl Acad Sci U S A. 1995 Dec 19; 92(26):12126-30. PMID: 8618857; PMCID: PMC40309.
    18. Ceberg CP, Brun A, Kahl S, Koo MS, Persson BR, Salford LG. A comparative study on the pharmacokinetics and biodistribution of boronated porphyrin (BOPP) and sulfhydryl boron hydride (BSH) in the RG2 rat glioma model. J Neurosurg. 1995 Jul; 83(1):86-92. PMID: 7782856.
      View in: PubMed
    19. Yamada Y, Toda K, Kahl S, Ichihashi M. Enhanced therapeutic effect on murine melanoma and angiosarcoma cells by boron neutron capture therapy using a boronated metalloporphyrin. Kobe J Med Sci. 1994 Feb; 40(1):25-37. PMID: 8035560.
      View in: PubMed
    20. Huang LR, Straubinger RM, Kahl S, Koo MS, Alletto JJ, Mazurchuk R, Chau RI, Thamer SL, Fiel RJ. Boronated metalloporphyrins: a novel approach to the diagnosis and treatment of cancer using contrast-enhanced MR imaging and neutron capture therapy. J Magn Reson Imaging. 1993 Mar-Apr; 3(2):351-6. PMID: 8448397.
      View in: PubMed
    21. DeCamp DL, Babé LM, Salto R, Lucich JL, Koo MS, Kahl S, Craik CS. Specific inhibition of HIV-1 protease by boronated porphyrins. J Med Chem. 1992 Sep 4; 35(18):3426-8. PMID: 1527792.
      View in: PubMed
    22. Hill JS, Kahl S, Kaye AH, Stylli SS, Koo MS, Gonzales MF, Vardaxis NJ, Johnson CI. Selective tumor uptake of a boronated porphyrin in an animal model of cerebral glioma. Proc Natl Acad Sci U S A. 1992 Mar 1; 89(5):1785-9. PMID: 1542672; PMCID: PMC48537.
    23. Laster BH, Kahl S, Popenoe EA, Pate DW, Fairchild RG. Biological efficacy of boronated low-density lipoprotein for boron neutron capture therapy as measured in cell culture. Cancer Res. 1991 Sep 1; 51(17):4588-93. PMID: 1873803.
      View in: PubMed
    24. Kahl S, Joel DD, Nawrocky MM, Micca PL, Tran KP, Finkel GC, Slatkin DN. Uptake of a nido-carboranylporphyrin by human glioma xenografts in athymic nude mice and by syngeneic ovarian carcinomas in immunocompetent mice. Proc Natl Acad Sci U S A. 1990 Sep; 87(18):7265-9. PMID: 2402507; PMCID: PMC54724.
    25. Fairchild RG, Kahl S, Laster BH, Kalef-Ezra J, Popenoe EA. In vitro determination of uptake, retention, distribution, biological efficacy, and toxicity of boronated compounds for neutron capture therapy: a comparison of porphyrins with sulfhydryl boron hydrides. Cancer Res. 1990 Aug 15; 50(16):4860-5. PMID: 2379150.
      View in: PubMed
    26. Fairchild RG, Slatkin DN, Coderre JA, Micca PL, Laster BH, Kahl S, Som P, Fand I, Wheeler F. Optimization of boron and neutron delivery for neutron capture therapy. Pigment Cell Res. 1989 Jul-Aug; 2(4):309-18. PMID: 2798323.
      View in: PubMed
    27. Fairchild RG, Wheeler F, Slatkin DN, Coderre J, Micca P, Laster B, Kahl S, Som P, Fand I. Recent developments in neutron capture therapy. Strahlenther Onkol. 1989 Apr; 165(4):343-7. PMID: 2711346.
      View in: PubMed
    28. Allen BJ, Brown JK, Mountford MH, Tamat SR, Patwardhan A, Moore DE, Ichihashi M, Mishima Y, Kahl S. In vitro and in vivo studies of boron conjugated melanoma affined biochemicals. Strahlenther Onkol. 1989 Feb-Mar; 165(2-3):163-5. PMID: 2928939.
      View in: PubMed
    29. Laster BH, Kahl S, Kalef-Ezra J, Popenoe EA, Fairchild RG. Biological efficacy of a boronated porphyrin as measured in cell culture. Strahlenther Onkol. 1989 Feb-Mar; 165(2-3):203-5. PMID: 2494728.
      View in: PubMed
    30. Kahl S, Callaway JC. New tumor localizers: advances in the use of low density lipoproteins (LDL). Strahlenther Onkol. 1989 Feb-Mar; 165(2-3):137-9. PMID: 2928936.
      View in: PubMed
    31. Kahl S, Koo MS, Laster BH, Fairchild RG. Boronated porphyrins in NCT: results with a new potent tumor localizer. Strahlenther Onkol. 1989 Feb-Mar; 165(2-3):134-7. PMID: 2928935.
      View in: PubMed
    32. Kahl S, Laster BH, Koo MS, Warkentien LS, Fairchild RG. Distribution of a boronated porphyrin in murine tumors. Basic Life Sci. 1989; 50:205-12. PMID: 2751609.
      View in: PubMed
    33. Laster BH, Kahl S, Popenoe EA, Gordon C, Kalef-Ezra J, Fairchild RG. Survival assays with a boronated porphyrin as measured with hamster V-79 cells in culture. Basic Life Sci. 1989; 50:213-8. PMID: 2751611.
      View in: PubMed
    34. Kahl S, Joel DD, Finkel GC, Micca PL, Nawrocky MM, Coderre JA, Slatkin DN. A carboranyl porphyrin for boron neutron capture therapy of brain tumors. Basic Life Sci. 1989; 50:193-203. PMID: 2751608.
      View in: PubMed
    Stephen's Networks
    Concepts
    Derived automatically from this person's publications.
    _
    Co-Authors
    People in Profiles who have published with this person.
    _
    Related Authors
    People who share related concepts with this person.
    _
    Back to TOP