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Stephen Kahl, PhD

TitleProfessor
SchoolUCSF School of Pharmacy
DepartmentPharmaceutical Chemistry
Address513 Parnassus Ave, Med Sci
San Francisco CA 94143
Phone415-476-4684
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    Collapse Research 
    Collapse Research Activities and Funding
    In vivo feasibility of a peripheral nerve imaging agent
    NIH R43CA180745Sep 1, 2013 - Feb 28, 2014
    Role: Principal Investigator
    Program for Development of BNCT Agents
    NIH R01CA082478Mar 1, 2000 - Jan 31, 2012
    Role: Principal Investigator
    DESIGN/SYNTHESIS OF BORONATED TUMOR-SEEKING MACROCYCLIC
    NIH R01CA053901Sep 18, 1991 - Jul 31, 1996
    Role: Principal Investigator
    BORONATED LIPOPROTEIN SITE SPECIFIC RADIOCHEMOTHERAPY
    NIH R01CA041487Jun 1, 1986 - May 31, 1990
    Role: Principal Investigator
    BORONATED TUMOR-SEEKING PORPHYRINS--SYNTHESIS &TESTING
    NIH R01CA037961Jul 1, 1985 - Mar 31, 1997
    Role: Principal Investigator
    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Koo MS, Ozawa T, Santos RA, Lamborn KR, Bollen AW, Deen DF, Kahl SB. Synthesis and comparative toxicology of a series of polyhedral borane anion-substituted tetraphenyl porphyrins. J Med Chem. 2007 Feb 22; 50(4):820-7. PMID: 17253677.
      View in: PubMed
    2. Dozzo P, Kasar RA, Kahl SB. Simple, high-yield methods for the synthesis of aldehydes directly from o-, m-, and p-carborane and their further conversions. Inorg Chem. 2005 Oct 31; 44(22):8053-7. PMID: 16241155.
      View in: PubMed
    3. Ozawa T, Afzal J, Lamborn KR, Bollen AW, Bauer WF, Koo MS, Kahl SB, Deen DF. Toxicity, biodistribution, and convection-enhanced delivery of the boronated porphyrin BOPP in the 9L intracerebral rat glioma model. Int J Radiat Oncol Biol Phys. 2005 Sep 1; 63(1):247-52. PMID: 16111595.
      View in: PubMed
    4. Dagrosa MA, Viaggi M, Rebagliati RJ, Batistoni D, Kahl SB, Juvenal GJ, Pisarev MA. Biodistribution of boron compounds in an animal model of human undifferentiated thyroid cancer for boron neutron capture therapy. Mol Pharm. 2005 Mar-Apr; 2(2):151-6. PMID: 15804189.
      View in: PubMed
    5. Dozzo P, Koo MS, Berger S, Forte TM, Kahl SB. Synthesis, characterization, and plasma lipoprotein association of a nucleus-targeted boronated porphyrin. J Med Chem. 2005 Jan 27; 48(2):357-9. PMID: 15658849.
      View in: PubMed
    6. Ozawa T, Santos RA, Lamborn KR, Bauer WF, Koo MS, Kahl SB, Deen DF. In vivo evaluation of the boronated porphyrin TABP-1 in U-87 MG intracerebral human glioblastoma xenografts. Mol Pharm. 2004 Sep-Oct; 1(5):368-74. PMID: 16026007.
      View in: PubMed
    7. Tibbitts J, Sambol NC, Fike JR, Bauer WF, Kahl SB. Plasma pharmacokinetics and tissue biodistribution of boron following administration of a boronated porphyrin in dogs. J Pharm Sci. 2000 Apr; 89(4):469-77. PMID: 10737908.
      View in: PubMed
    8. Kasar RA, Knudsen GM, Kahl SB. Synthesis of 3-Amino-1-carboxy-o-carborane and an Improved, General Method for the Synthesis of All Three C-Amino-C-carboxycarboranes. Inorg Chem. 1999 Jun 14; 38(12):2936-2940. PMID: 11671041.
      View in: PubMed
    9. Tibbitts J, Fike JR, Lamborn KR, Bollen AW, Kahl SB. Toxicology of a boronated porphyrin in dogs. Photochem Photobiol. 1999 May; 69(5):587-94. PMID: 10333766.
      View in: PubMed
    10. DeCamp DL, Babé LM, Salto R, Lucich JL, Koo MS, Kahl S, Craik CS. Specific inhibition of HIV-1 protease by boronated porphyrins. J Med Chem. 1992 Sep 4; 35(18):3426-8. PMID: 1527792.
      View in: PubMed
    11. Kahl S, Joel DD, Nawrocky MM, Micca PL, Tran KP, Finkel GC, Slatkin DN. Uptake of a nido-carboranylporphyrin by human glioma xenografts in athymic nude mice and by syngeneic ovarian carcinomas in immunocompetent mice. Proc Natl Acad Sci U S A. 1990 Sep; 87(18):7265-9. PMID: 2402507; PMCID: PMC54724.
    12. Kahl S, Callaway JC. New tumor localizers: advances in the use of low density lipoproteins (LDL). Strahlenther Onkol. 1989 Feb-Mar; 165(2-3):137-9. PMID: 2928936.
      View in: PubMed
    13. Kahl S, Koo MS, Laster BH, Fairchild RG. Boronated porphyrins in NCT: results with a new potent tumor localizer. Strahlenther Onkol. 1989 Feb-Mar; 165(2-3):134-7. PMID: 2928935.
      View in: PubMed
    14. Kahl S, Laster BH, Koo MS, Warkentien LS, Fairchild RG. Distribution of a boronated porphyrin in murine tumors. Basic Life Sci. 1989; 50:205-12. PMID: 2751609.
      View in: PubMed
    15. Kahl S, Joel DD, Finkel GC, Micca PL, Nawrocky MM, Coderre JA, Slatkin DN. A carboranyl porphyrin for boron neutron capture therapy of brain tumors. Basic Life Sci. 1989; 50:193-203. PMID: 2751608.
      View in: PubMed
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