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eLife Digest. Defective enzyme weakens cell wall. 2020.
Allison Hillary Williams et al. . View Publication.
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Defective lytic transglycosylase disrupts cell morphogenesis by hindering cell wall de-O-acetylation in Neisseria meningitidis. Elife. 2020 02 05; 9.
Williams AH, Wheeler R, Deghmane AE, Santecchia I, Schaub RE, Hicham S, Moya Nilges M, Malosse C, Chamot-Rooke J, Haouz A, Dillard JP, Robins WP, Taha MK, Gomperts Boneca I. PMID: 32022687.
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1 Fields:
Translation:
Cells
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The cryo-electron microscopy supramolecular structure of the bacterial stressosome unveils its mechanism of activation. Nat Commun. 2019 07 08; 10(1):3005.
Williams AH, Redzej A, Rolhion N, Costa TRD, Rifflet A, Waksman G, Cossart P. PMID: 31285450.
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4 Fields:
Translation:
Cells
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Structure guided design of an antibacterial peptide that targets UDP-N-acetylglucosamine acyltransferase. Sci Rep. 2019 03 08; 9(1):3947.
Dangkulwanich M, Raetz CRH, Williams AH. PMID: 30850651.
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2 Fields:
Translation:
Cells
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Author Correction: N-terminomics identifies Prli42 as a membrane miniprotein conserved in Firmicutes and critical for stressosome activation in Listeria monocytogenes. Nat Microbiol. 2018 Aug; 3(8):962.
Impens F, Rolhion N, Radoshevich L, Bécavin C, Duval M, Mellin J, García Del Portillo F, Pucciarelli MG, Williams AH, Cossart P. PMID: 29941881.
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A step-by-step in crystallo guide to bond cleavage and 1,6-anhydro-sugar product synthesis by a peptidoglycan-degrading lytic transglycosylase. J Biol Chem. 2018 04 20; 293(16):6000-6010.
Williams AH, Wheeler R, Rateau L, Malosse C, Chamot-Rooke J, Haouz A, Taha MK, Boneca IG. PMID: 29483188.
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PubMed Mentions:
4 Fields:
Translation:
Cells
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Bulgecin A: The Key to a Broad-Spectrum Inhibitor That Targets Lytic Transglycosylases. Antibiotics (Basel). 2017 Feb 22; 6(1).
Williams AH, Wheeler R, Thiriau C, Haouz A, Taha MK, Boneca IG. PMID: 28241458.
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N-terminomics identifies Prli42 as a membrane miniprotein conserved in Firmicutes and critical for stressosome activation in Listeria monocytogenes. Nat Microbiol. 2017 Feb 13; 2:17005.
Impens F, Rolhion N, Radoshevich L, Bécavin C, Duval M, Mellin J, García Del Portillo F, Pucciarelli MG, Williams AH, Cossart P. PMID: 28191904.
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21 Fields:
Translation:
Cells
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Visualization of a substrate-induced productive conformation of the catalytic triad of the Neisseria meningitidis peptidoglycan O-acetylesterase reveals mechanistic conservation in SGNH esterase family members. Acta Crystallogr D Biol Crystallogr. 2014 Oct; 70(Pt 10):2631-9.
Williams AH, Veyrier FJ, Bonis M, Michaud Y, Raynal B, Taha MK, White SW, Haouz A, Boneca IG. PMID: 25286847.
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PubMed Mentions:
8 Fields:
Translation:
Cells
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The dynamics of peptidoglycan structure and function: conference report on the 3rd Great Wall Symposium. Res Microbiol. 2014 Jan; 165(1):60-7.
Williams AH, Boneca IG, Burrows LL, Bugg TD. PMID: 24239960.
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2 Fields:
Translation:
Cells
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De-O-acetylation of peptidoglycan regulates glycan chain extension and affects in vivo survival of Neisseria meningitidis. Mol Microbiol. 2013 Mar; 87(5):1100-12.
Veyrier FJ, Williams AH, Mesnage S, Schmitt C, Taha MK, Boneca IG. PMID: 23373517.
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PubMed Mentions:
17 Fields:
Translation:
HumansAnimalsCells
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Atg8 transfer from Atg7 to Atg3: a distinctive E1-E2 architecture and mechanism in the autophagy pathway. Mol Cell. 2011 Nov 04; 44(3):451-61.
Taherbhoy AM, Tait SW, Kaiser SE, Williams AH, Deng A, Nourse A, Hammel M, Kurinov I, Rock CO, Green DR, Schulman BA. PMID: 22055190.
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PubMed Mentions:
62 Fields:
Translation:
AnimalsCells
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Structural basis for the sugar nucleotide and acyl-chain selectivity of Leptospira interrogans LpxA. Biochemistry. 2009 Jul 07; 48(26):6191-201.
Robins LI, Williams AH, Raetz CR. PMID: 19456129.
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18 Fields:
Translation:
Cells
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Structural basis for the acyl chain selectivity and mechanism of UDP-N-acetylglucosamine acyltransferase. Proc Natl Acad Sci U S A. 2007 Aug 21; 104(34):13543-50.
Williams AH, Raetz CR. PMID: 17698807.
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PubMed Mentions:
28 Fields:
Translation:
Cells
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Structure of UDP-N-acetylglucosamine acyltransferase with a bound antibacterial pentadecapeptide. Proc Natl Acad Sci U S A. 2006 Jul 18; 103(29):10877-82.
Williams AH, Immormino RM, Gewirth DT, Raetz CR. PMID: 16835299.
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24 Fields:
Translation:
Cells
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Enzymatic synthesis of lipid A molecules with four amide-linked acyl chains. LpxA acyltransferases selective for an analog of UDP-N-acetylglucosamine in which an amine replaces the 3"-hydroxyl group. J Biol Chem. 2004 Jun 11; 279(24):25411-9.
Sweet CR, Williams AH, Karbarz MJ, Werts C, Kalb SR, Cotter RJ, Raetz CR. PMID: 15044493.
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PubMed Mentions:
16 Fields:
Translation:
Cells