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Defective lytic transglycosylase disrupts cell morphogenesis by hindering cell wall de-O-acetylation in Neisseria meningitidis. Elife. 2020 02 05; 9.
Williams AH, Wheeler R, Deghmane AE, Santecchia I, Schaub RE, Hicham S, Moya Nilges M, Malosse C, Chamot-Rooke J, Haouz A, Dillard JP, Robins WP, Taha MK, Gomperts Boneca I. PMID: 32022687.
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1 Fields:
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Cells
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The cryo-electron microscopy supramolecular structure of the bacterial stressosome unveils its mechanism of activation. Nat Commun. 2019 07 08; 10(1):3005.
Williams AH, Redzej A, Rolhion N, Costa TRD, Rifflet A, Waksman G, Cossart P. PMID: 31285450.
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6 Fields:
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Cells
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Structure guided design of an antibacterial peptide that targets UDP-N-acetylglucosamine acyltransferase. Sci Rep. 2019 03 08; 9(1):3947.
Dangkulwanich M, Raetz CRH, Williams AH. PMID: 30850651.
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2 Fields:
Translation:
Cells
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Author Correction: N-terminomics identifies Prli42 as a membrane miniprotein conserved in Firmicutes and critical for stressosome activation in Listeria monocytogenes. Nat Microbiol. 2018 Aug; 3(8):962.
Impens F, Rolhion N, Radoshevich L, Bécavin C, Duval M, Mellin J, García Del Portillo F, Pucciarelli MG, Williams AH, Cossart P. PMID: 29941881.
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A step-by-step in crystallo guide to bond cleavage and 1,6-anhydro-sugar product synthesis by a peptidoglycan-degrading lytic transglycosylase. J Biol Chem. 2018 04 20; 293(16):6000-6010.
Williams AH, Wheeler R, Rateau L, Malosse C, Chamot-Rooke J, Haouz A, Taha MK, Boneca IG. PMID: 29483188.
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4 Fields:
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Cells
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Bulgecin A: The Key to a Broad-Spectrum Inhibitor That Targets Lytic Transglycosylases. Antibiotics (Basel). 2017 Feb 22; 6(1).
Williams AH, Wheeler R, Thiriau C, Haouz A, Taha MK, Boneca IG. PMID: 28241458.
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10
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N-terminomics identifies Prli42 as a membrane miniprotein conserved in Firmicutes and critical for stressosome activation in Listeria monocytogenes. Nat Microbiol. 2017 Feb 13; 2:17005.
Impens F, Rolhion N, Radoshevich L, Bécavin C, Duval M, Mellin J, García Del Portillo F, Pucciarelli MG, Williams AH, Cossart P. PMID: 28191904.
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22 Fields:
Translation:
Cells
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Visualization of a substrate-induced productive conformation of the catalytic triad of the Neisseria meningitidis peptidoglycan O-acetylesterase reveals mechanistic conservation in SGNH esterase family members. Acta Crystallogr D Biol Crystallogr. 2014 Oct; 70(Pt 10):2631-9.
Williams AH, Veyrier FJ, Bonis M, Michaud Y, Raynal B, Taha MK, White SW, Haouz A, Boneca IG, Williams AH, Veyrier FJ, Bonis M, Michaud Y, Raynal B, Taha MK, White SW, Haouz A, Boneca IG. PMID: 25286847; PMCID: PMC4188005.
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8 Fields:
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Cells
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The dynamics of peptidoglycan structure and function: conference report on the 3rd Great Wall Symposium. Res Microbiol. 2014 Jan; 165(1):60-7.
Williams AH, Boneca IG, Burrows LL, Bugg TD, Williams AH, Boneca IG, Burrows LL, Bugg TD. PMID: 24239960.
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PubMed Mentions:
2 Fields:
Translation:
Cells
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De-O-acetylation of peptidoglycan regulates glycan chain extension and affects in vivo survival of Neisseria meningitidis. Mol Microbiol. 2013 Mar; 87(5):1100-12.
Veyrier FJ, Williams AH, Mesnage S, Schmitt C, Taha MK, Boneca IG, Veyrier FJ, Williams AH, Mesnage S, Schmitt C, Taha MK, Boneca IG. PMID: 23373517.
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PubMed Mentions:
18 Fields:
Translation:
HumansAnimalsCells
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Atg8 transfer from Atg7 to Atg3: a distinctive E1-E2 architecture and mechanism in the autophagy pathway. Mol Cell. 2011 Nov 04; 44(3):451-61.
Taherbhoy AM, Tait SW, Kaiser SE, Williams AH, Deng A, Nourse A, Hammel M, Kurinov I, Rock CO, Green DR, Schulman BA, Taherbhoy AM, Tait SW, Kaiser SE, Williams AH, Deng A, Nourse A, Hammel M, Kurinov I, Rock CO, Green DR, Schulman BA. PMID: 22055190; PMCID: PMC3277881.
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PubMed Mentions:
65 Fields:
Translation:
AnimalsCells
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Structural basis for the sugar nucleotide and acyl-chain selectivity of Leptospira interrogans LpxA. Biochemistry. 2009 Jul 07; 48(26):6191-201.
Robins LI, Williams AH, Raetz CR, Robins LI, Williams AH, Raetz CR. PMID: 19456129; PMCID: PMC2710806.
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PubMed Mentions:
18 Fields:
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Cells
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Structural basis for the acyl chain selectivity and mechanism of UDP-N-acetylglucosamine acyltransferase. Proc Natl Acad Sci U S A. 2007 Aug 21; 104(34):13543-50.
Williams AH, Raetz CR, Williams AH, Raetz CR. PMID: 17698807; PMCID: PMC1959417.
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28 Fields:
Translation:
Cells
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Structure of UDP-N-acetylglucosamine acyltransferase with a bound antibacterial pentadecapeptide. Proc Natl Acad Sci U S A. 2006 Jul 18; 103(29):10877-82.
Williams AH, Immormino RM, Gewirth DT, Raetz CR, Williams AH, Immormino RM, Gewirth DT, Raetz CR. PMID: 16835299; PMCID: PMC1544142.
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24 Fields:
Translation:
Cells
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Enzymatic synthesis of lipid A molecules with four amide-linked acyl chains. LpxA acyltransferases selective for an analog of UDP-N-acetylglucosamine in which an amine replaces the 3"-hydroxyl group. J Biol Chem. 2004 Jun 11; 279(24):25411-9.
Sweet CR, Williams AH, Karbarz MJ, Werts C, Kalb SR, Cotter RJ, Raetz CR, Sweet CR, Williams AH, Karbarz MJ, Werts C, Kalb SR, Cotter RJ, Raetz CR. PMID: 15044493; PMCID: PMC2597548.
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PubMed Mentions:
16 Fields:
Translation:
Cells