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An adenoviral-vectored vaccine confers seroprotection against capsular group B meningococcal disease. Sci Transl Med. 2023 06 21; 15(701):eade3901.
Dold C, Marsay L, Wang N, Silva-Reyes L, Clutterbuck E, Paterson GK, Sharkey K, Wyllie D, Beernink PT, Hill AV, Pollard AJ, Rollier CS. PMID: 37343082.
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PubMed Mentions: Fields:
Translation:
HumansAnimalsCells
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Two human antibodies to a meningococcal serogroup B vaccine antigen enhance binding of complement Factor H by stabilizing the Factor H binding site. PLoS Pathog. 2021 06; 17(6):e1009655.
Sands NA, Beernink PT. PMID: 34125873; PMCID: PMC8224966.
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PubMed Mentions: Fields:
Translation:
HumansCells
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Broad vaccine protection against Neisseria meningitidis using factor H binding protein. Vaccine. 2020 11 17; 38(49):7716-7727.
Findlow J, Bayliss CD, Beernink PT, Borrow R, Liberator P, Balmer P. PMID: 32878710; PMCID: PMC8082720.
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PubMed Mentions:
1 Fields:
Translation:
HumansCells
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Effect of complement Factor H on antibody repertoire and protection elicited by meningococcal capsular group B vaccines containing Factor H binding protein. Hum Vaccin Immunother. 2020 03 03; 16(3):703-712.
Beernink PT. PMID: 31526219; PMCID: PMC7227650.
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PubMed Mentions: Fields:
Translation:
HumansAnimalsCells
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Anti-Factor H Antibody Reactivity in Young Adults Vaccinated with a Meningococcal Serogroup B Vaccine Containing Factor H Binding Protein. mSphere. 2019 07 03; 4(4).
Sharkey K, Beernink PT, Langley JM, Gantt S, Quach C, Dold C, Liu Q, Galvan M, Granoff DM. PMID: 31270173; PMCID: PMC6609231.
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PubMed Mentions:
6 Fields:
Translation:
HumansCells
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A Meningococcal Outer Membrane Vesicle Vaccine with Overexpressed Mutant FHbp Elicits Higher Protective Antibody Responses in Infant Rhesus Macaques than a Licensed Serogroup B Vaccine. mBio. 2019 06 18; 10(3).
Beernink PT, Vianzon V, Lewis LA, Moe GR, Granoff DM. PMID: 31213564; PMCID: PMC6581866.
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PubMed Mentions:
16 Fields:
Translation:
AnimalsCells
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A Meningococcal Native Outer Membrane Vesicle Vaccine With Attenuated Endotoxin and Overexpressed Factor H Binding Protein Elicits Gonococcal Bactericidal Antibodies. J Infect Dis. 2019 03 15; 219(7):1130-1137.
Beernink PT, Ispasanie E, Lewis LA, Ram S, Moe GR, Granoff DM. PMID: 30346576; PMCID: PMC6420169.
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PubMed Mentions:
21 Fields:
Translation:
HumansAnimalsCells
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Molecular characterization of two sub-family specific monoclonal antibodies to meningococcal Factor H binding protein. Heliyon. 2018 Apr; 4(4):e00591.
Lo Passo C, Zippilli L, Angiolillo A, Costa I, Pernice I, Galbo R, Felici F, Beernink PT. PMID: 29644339; PMCID: PMC5889710.
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PubMed Mentions:
1
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Crystal structure reveals vaccine elicited bactericidal human antibody targeting a conserved epitope on meningococcal fHbp. Nat Commun. 2018 02 06; 9(1):528.
López-Sagaseta J, Beernink PT, Bianchi F, Santini L, Frigimelica E, Lucas AH, Pizza M, Bottomley MJ. PMID: 29410413; PMCID: PMC5802752.
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PubMed Mentions:
12 Fields:
Translation:
HumansCells
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Charge neutralization in the active site of the catalytic trimer of aspartate transcarbamoylase promotes diverse structural changes. Protein Sci. 2017 Nov; 26(11):2221-2228.
Endrizzi JA, Beernink PT. PMID: 28833948; PMCID: PMC5654843.
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Translation:
HumansCells
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Neisseria meningitidis factor H-binding protein bound to monoclonal antibody JAR5: implications for antibody synergy. Biochem J. 2016 Dec 15; 473(24):4699-4713.
Malito E, Lo Surdo P, Veggi D, Santini L, Stefek H, Brunelli B, Luzzi E, Bottomley MJ, Beernink PT, Scarselli M. PMID: 27784765; PMCID: PMC6398935.
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PubMed Mentions:
11 Fields:
Translation:
Cells
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Enhanced protective antibody to a mutant meningococcal factor H-binding protein with low-factor H binding. JCI Insight. 2016 Sep 08; 1(14):e88907.
Granoff DM, Giuntini S, Gowans FA, Lujan E, Sharkey K, Beernink PT. PMID: 27668287; PMCID: PMC5033880.
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PubMed Mentions:
14 Fields:
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Human IgG1, IgG3, and IgG3 Hinge-Truncated Mutants Show Different Protection Capabilities against Meningococci Depending on the Target Antigen and Epitope Specificity. Clin Vaccine Immunol. 2016 08; 23(8):698-706.
Giuntini S, Granoff DM, Beernink PT, Ihle O, Bratlie D, Michaelsen TE. PMID: 27307451; PMCID: PMC4979173.
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PubMed Mentions:
26 Fields:
Translation:
HumansAnimalsCells
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Meningococcal Factor H Binding Protein Vaccine Antigens with Increased Thermal Stability and Decreased Binding of Human Factor H. Infect Immun. 2016 06; 84(6):1735-1742.
Rossi R, Konar M, Beernink PT. PMID: 27021245; PMCID: PMC4907147.
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PubMed Mentions:
8 Fields:
Translation:
HumansAnimalsCells
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A meningococcal vaccine antigen engineered to increase thermal stability and stabilize protective epitopes. Proc Natl Acad Sci U S A. 2015 Dec 01; 112(48):14823-8.
Konar M, Pajon R, Beernink PT. PMID: 26627237; PMCID: PMC4672778.
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PubMed Mentions:
9 Fields:
Translation:
HumansCells
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Effect of complement Factor H on anti-FHbp serum bactericidal antibody responses of infant rhesus macaques boosted with a licensed meningococcal serogroup B vaccine. Vaccine. 2015 Dec 16; 33(51):7168-7175.
Giuntini S, Beernink PT, Granoff DM. PMID: 26562320; PMCID: PMC4684420.
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PubMed Mentions:
11 Fields:
Translation:
Animals
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Susceptibility of Meningococcal Strains Responsible for Two Serogroup B Outbreaks on U.S. University Campuses to Serum Bactericidal Activity Elicited by the MenB-4C Vaccine. Clin Vaccine Immunol. 2015 Dec; 22(12):1227-34.
Rossi R, Beernink PT, Giuntini S, Granoff DM. PMID: 26424832; PMCID: PMC4658582.
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PubMed Mentions:
12 Fields:
Translation:
HumansAnimalsCells
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A Newly-Identified Polymorphism in Rhesus Macaque Complement Factor H Modulates Binding Affinity for Meningococcal FHbp. PLoS One. 2015; 10(8):e0135996.
Konar M, Beernink PT, Granoff DM. PMID: 26285122; PMCID: PMC4540320.
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PubMed Mentions:
5 Fields:
Translation:
HumansAnimals
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Functional Analysis of the Human Antibody Response to Meningococcal Factor H Binding Protein. mBio. 2015 Jun 23; 6(3):e00842.
Beernink PT, Giuntini S, Costa I, Lucas AH, Granoff DM. PMID: 26106082; PMCID: PMC4479705.
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PubMed Mentions:
12 Fields:
Translation:
HumansAnimalsCells
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A Mutant Library Approach to Identify Improved Meningococcal Factor H Binding Protein Vaccine Antigens. PLoS One. 2015; 10(6):e0128185.
Konar M, Rossi R, Walter H, Pajon R, Beernink PT. PMID: 26057742; PMCID: PMC4461315.
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PubMed Mentions:
13 Fields:
Translation:
HumansAnimalsCells
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Binding of Complement Factor H (FH) Decreases Protective Anti-FH Binding Protein Antibody Responses of Infant Rhesus Macaques Immunized With a Meningococcal Serogroup B Vaccine. J Infect Dis. 2015 Sep 01; 212(5):784-92.
Granoff DM, Costa I, Konar M, Giuntini S, Van Rompay KK, Beernink PT. PMID: 25676468; PMCID: PMC4539902.
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PubMed Mentions:
22 Fields:
Translation:
AnimalsCells
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Heterogeneity in rhesus macaque complement factor H binding to meningococcal factor H binding protein (FHbp) informs selection of primates to assess immunogenicity of FHbp-based vaccines. Clin Vaccine Immunol. 2014 Nov; 21(11):1505-11.
Beernink PT, Shaughnessy J, Stefek H, Ram S, Granoff DM. PMID: 25185576; PMCID: PMC4248754.
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PubMed Mentions:
14 Fields:
Translation:
AnimalsCells
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Meningococcal factor H-binding protein vaccines with decreased binding to human complement factor H have enhanced immunogenicity in human factor H transgenic mice. Vaccine. 2013 Nov 04; 31(46):5451-7.
Rossi R, Granoff DM, Beernink PT. PMID: 24035433; PMCID: PMC3867019.
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PubMed Mentions:
21 Fields:
Translation:
HumansAnimalsCells
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Does binding of complement factor H to the meningococcal vaccine antigen, factor H binding protein, decrease protective serum antibody responses? Clin Vaccine Immunol. 2013 Aug; 20(8):1099-107.
Granoff DM, Ram S, Beernink PT. PMID: 23740919; PMCID: PMC3754512.
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PubMed Mentions:
15 Fields:
Translation:
HumansAnimalsCells
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Importance of inhibition of binding of complement factor H for serum bactericidal antibody responses to meningococcal factor H-binding protein vaccines. J Infect Dis. 2013 Aug 15; 208(4):627-36.
Konar M, Granoff DM, Beernink PT. PMID: 23715659; PMCID: PMC3719908.
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PubMed Mentions:
24 Fields:
Translation:
HumansAnimals
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Design of meningococcal factor H binding protein mutant vaccines that do not bind human complement factor H. Infect Immun. 2012 Aug; 80(8):2667-77.
Pajon R, Beernink PT, Granoff DM. PMID: 22615247; PMCID: PMC3434564.
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PubMed Mentions:
17 Fields:
Translation:
HumansAnimalsCells
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The effect of human factor H on immunogenicity of meningococcal native outer membrane vesicle vaccines with over-expressed factor H binding protein. PLoS Pathog. 2012; 8(5):e1002688.
Beernink PT, Shaughnessy J, Pajon R, Braga EM, Ram S, Granoff DM. PMID: 22589720; PMCID: PMC3349754.
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PubMed Mentions:
32 Fields:
Translation:
HumansAnimalsCells
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Monoclonal antibodies to meningococcal factor H binding protein with overlapping epitopes and discordant functional activity. PLoS One. 2012; 7(3):e34272.
Giuntini S, Beernink PT, Reason DC, Granoff DM. PMID: 22461909; PMCID: PMC3312907.
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PubMed Mentions:
16 Fields:
Translation:
HumansAnimalsCells
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A meningococcal factor H binding protein mutant that eliminates factor H binding enhances protective antibody responses to vaccination. J Immunol. 2011 Mar 15; 186(6):3606-14.
Beernink PT, Shaughnessy J, Braga EM, Liu Q, Rice PA, Ram S, Granoff DM. PMID: 21325619; PMCID: PMC3098282.
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PubMed Mentions:
91 Fields:
Translation:
HumansAnimalsCells
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Effect of factor H-binding protein sequence variation on factor H binding and survival of Neisseria meningitidis in human blood. Infect Immun. 2011 Jan; 79(1):353-9.
Dunphy KY, Beernink PT, Brogioni B, Granoff DM. PMID: 21041484; PMCID: PMC3019890.
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PubMed Mentions:
23 Fields:
Translation:
HumansCells
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Impaired immunogenicity of a meningococcal factor H-binding protein vaccine engineered to eliminate factor h binding. Clin Vaccine Immunol. 2010 Jul; 17(7):1074-8.
Beernink PT, Shaughnessy J, Ram S, Granoff DM. PMID: 20519444; PMCID: PMC2897264.
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PubMed Mentions:
19 Fields:
Translation:
HumansAnimalsCells
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Frequency of factor H-binding protein modular groups and susceptibility to cross-reactive bactericidal activity in invasive meningococcal isolates. Vaccine. 2010 Feb 25; 28(9):2122-9.
Pajon R, Beernink PT, Harrison LH, Granoff DM. PMID: 20044056; PMCID: PMC2830318.
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PubMed Mentions:
41 Fields:
Translation:
AnimalsCells
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The modular architecture of meningococcal factor H-binding protein. Microbiology (Reading). 2009 Sep; 155(Pt 9):2873-2883.
Beernink PT, Granoff DM. PMID: 19574307; PMCID: PMC2859308.
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PubMed Mentions:
36 Fields:
Translation:
HumansCells
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Meningococcal factor H-binding protein variants expressed by epidemic capsular group A, W-135, and X strains from Africa. J Infect Dis. 2009 May 01; 199(9):1360-8.
Beernink PT, Caugant DA, Welsch JA, Koeberling O, Granoff DM. PMID: 19302008; PMCID: PMC2914608.
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PubMed Mentions:
41 Fields:
Translation:
HumansCells
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A region of the N-terminal domain of meningococcal factor H-binding protein that elicits bactericidal antibody across antigenic variant groups. Mol Immunol. 2009 May; 46(8-9):1647-53.
Beernink PT, LoPasso C, Angiolillo A, Felici F, Granoff D. PMID: 19286260; PMCID: PMC2673115.
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PubMed Mentions:
28 Fields:
Translation:
Cells
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Fine antigenic specificity and cooperative bactericidal activity of monoclonal antibodies directed at the meningococcal vaccine candidate factor h-binding protein. Infect Immun. 2008 Sep; 76(9):4232-40.
Beernink PT, Welsch JA, Bar-Lev M, Koeberling O, Comanducci M, Granoff DM. PMID: 18591239; PMCID: PMC2519416.
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PubMed Mentions:
53 Fields:
Translation:
HumansAnimalsCells
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Bactericidal antibody responses induced by meningococcal recombinant chimeric factor H-binding protein vaccines. Infect Immun. 2008 Jun; 76(6):2568-75.
Beernink PT, Granoff DM. PMID: 18362128; PMCID: PMC2423104.
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PubMed Mentions:
43 Fields:
Translation:
AnimalsCells
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Identification of a thermo-regulated glutamine-binding protein from Yersinia pestis. Protein Pept Lett. 2008; 15(9):887-94.
Cosman M, Pesavento JB, Zemla A, Beernink PT, Balhorn R, Barsky D. PMID: 18991762.
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PubMed Mentions: Fields:
Translation:
Cells
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Prevalence of factor H-binding protein variants and NadA among meningococcal group B isolates from the United States: implications for the development of a multicomponent group B vaccine. J Infect Dis. 2007 May 15; 195(10):1472-9.
Beernink PT, Welsch JA, Harrison LH, Leipus A, Kaplan SL, Granoff DM. PMID: 17436227; PMCID: PMC2245893.
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PubMed Mentions:
21 Fields:
Translation:
HumansCells
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Applications of functional protein microarrays: identifying protein-protein interactions in an array format. Methods Mol Biol. 2007; 385:121-30.
Coleman MA, Beernink PT, Camarero JA, Albala JS. PMID: 18365708.
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PubMed Mentions:
2 Fields:
Translation:
Cells
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Rapid genetic grouping of factor h-binding protein (genome-derived neisserial antigen 1870), a promising group B meningococcal vaccine candidate. Clin Vaccine Immunol. 2006 Jul; 13(7):758-63.
Beernink PT, Leipus A, Granoff DM. PMID: 16829612; PMCID: PMC1489572.
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PubMed Mentions:
16 Fields:
Translation:
HumansCells
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Specificity of protein interactions mediated by BRCT domains of the XRCC1 DNA repair protein. J Biol Chem. 2005 Aug 26; 280(34):30206-13.
Beernink PT, Hwang M, Ramirez M, Murphy MB, Doyle SA, Thelen MP. PMID: 15987676.
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PubMed Mentions:
25 Fields:
Translation:
HumansCells
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High-throughput, fluorescence-based screening for soluble protein expression. J Proteome Res. 2004 Sep-Oct; 3(5):1024-32.
Coleman MA, Lao VH, Segelke BW, Beernink PT. PMID: 15473692.
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PubMed Mentions:
12 Fields:
Translation:
HumansCells
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Identification of chromatin-related protein interactions using protein microarrays. Proteomics. 2003 Nov; 3(11):2101-7.
Coleman MA, Miller KA, Beernink PT, Yoshikawa DM, Albala JS. PMID: 14595808.
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PubMed Mentions:
5 Fields:
Translation:
HumansCells
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Thermodynamic analysis of the dissociation of the aldolase tetramer substituted at one or both of the subunit interfaces. Biol Chem. 2003 Oct-Nov; 384(10-11):1463-71.
Tolan DR, Schuler B, Beernink PT, Jaenicke R. PMID: 14669989.
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PubMed Mentions:
8 Fields:
Translation:
Cells
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Spatial clustering of isozyme-specific residues reveals unlikely determinants of isozyme specificity in fructose-1,6-bisphosphate aldolase. J Biol Chem. 2003 May 09; 278(19):17307-13.
Pezza JA, Choi KH, Berardini TZ, Beernink PT, Allen KN, Tolan DR. PMID: 12611890.
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PubMed Mentions:
14 Fields:
Translation:
HumansAnimalsCells
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Application of In Vitro Protein Expression to Human Prote. ScientificWorldJournal. 2002; 2:73-74.
Beernink PT, Krupka SS, Lao V, Martin G, Coleman MA. PMID: 29973809; PMCID: PMC6009240.
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PubMed Mentions: Fields:
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Structural basis for a change in substrate specificity: crystal structure of S113E isocitrate dehydrogenase in a complex with isopropylmalate, Mg2+, and NADP. Biochemistry. 2001 Apr 10; 40(14):4234-41.
Doyle SA, Beernink PT, Koshland DE. PMID: 11284679.
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PubMed Mentions:
5 Fields:
Translation:
Cells
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Two divalent metal ions in the active site of a new crystal form of human apurinic/apyrimidinic endonuclease, Ape1: implications for the catalytic mechanism. J Mol Biol. 2001 Apr 06; 307(4):1023-34.
Beernink PT, Segelke BW, Hadi MZ, Erzberger JP, Wilson DM, Rupp B. PMID: 11286553.
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PubMed Mentions:
72 Fields:
Translation:
HumansCells
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Random circular permutation leading to chain disruption within and near alpha helices in the catalytic chains of aspartate transcarbamoylase: effects on assembly, stability, and function. Protein Sci. 2001 Mar; 10(3):528-37.
Beernink PT, Yang YR, Graf R, King DS, Shah SS, Schachman HK. PMID: 11344321; PMCID: PMC2374132.
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PubMed Mentions:
6 Fields:
Translation:
Cells
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Binding of bisubstrate analog promotes large structural changes in the unregulated catalytic trimer of aspartate transcarbamoylase: implications for allosteric regulation. Proc Natl Acad Sci U S A. 2000 May 09; 97(10):5077-82.
Endrizzi JA, Beernink PT, Alber T, Schachman HK. PMID: 10805770; PMCID: PMC25784.
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PubMed Mentions:
14 Fields:
Translation:
Cells
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Assessment of the allosteric mechanism of aspartate transcarbamoylase based on the crystalline structure of the unregulated catalytic subunit. Proc Natl Acad Sci U S A. 1999 May 11; 96(10):5388-93.
Beernink PT, Endrizzi JA, Alber T, Schachman HK. PMID: 10318893; PMCID: PMC21869.
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PubMed Mentions:
19 Fields:
Translation:
Cells
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Disruption of the aldolase A tetramer into catalytically active monomers. Proc Natl Acad Sci U S A. 1996 May 28; 93(11):5374-9.
Beernink PT, Tolan DR. PMID: 8643582; PMCID: PMC39253.
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PubMed Mentions:
12 Fields:
Translation:
AnimalsCells
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Subunit interface mutants of rabbit muscle aldolase form active dimers. Protein Sci. 1994 Sep; 3(9):1383-91.
Beernink PT, Tolan DR. PMID: 7833800; PMCID: PMC2142937.
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PubMed Mentions:
13 Fields:
Translation:
HumansAnimalsCells
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Construction of a high-copy "ATG vector" for expression in Escherichia coli. Protein Expr Purif. 1992 Aug; 3(4):332-6.
Beernink PT, Tolan DR. PMID: 1422227.
View in:
PubMed Mentions:
6 Fields:
Translation:
Cells