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Discovery and Preclinical Characterization of BIIB129, a Covalent, Selective, and Brain-Penetrant BTK Inhibitor for the Treatment of Multiple Sclerosis. J Med Chem. 2024 May 23; 67(10):8122-8140.
Himmelbauer MK, Bajrami B, Basile R, Capacci A, Chen T, Choi CK, Gilfillan R, Gonzalez-Lopez de Turiso F, Gu C, Hoemberger M, Johnson DS, Jones JH, Kadakia E, Kirkland M, Lin EY, Liu Y, Ma B, Magee T, Mantena S, Marx IE, Metrick CM, Mingueneau M, Murugan P, Muste CA, Nadella P, Nevalainen M, Parker Harp CR, Pattaropong V, Pietrasiewicz A, Prince RJ, Purgett TJ, Santoro JC, Schulz J, Sciabola S, Tang H, Vandeveer HG, Wang T, Yousaf Z, Helal CJ, Hopkins BT. PMID: 38712838; PMCID: PMC11129193.
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PubMed Mentions:
1 Fields:
Translation:
HumansAnimals
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Elucidation of the GSK3α Structure Informs the Design of Novel, Paralog-Selective Inhibitors. ACS Chem Neurosci. 2023 03 15; 14(6):1080-1094.
Amaral B, Capacci A, Anderson T, Tezer C, Bajrami B, Lulla M, Lucas B, Chodaparambil JV, Marcotte D, Kumar PR, Murugan P, Spilker K, Cullivan M, Wang T, Peterson AC, Enyedy I, Ma B, Chen T, Yousaf Z, Calhoun M, Golonzhka O, Dillon GM, Koirala S. PMID: 36812145; PMCID: PMC10020971.
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PubMed Mentions:
2 Fields:
Translation:
Cells
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Design, synthesis and identification of novel, orally bioavailable non-covalent Nrf2 activators. Bioorg Med Chem Lett. 2020 02 15; 30(4):126852.
Ma B, Lucas B, Capacci A, Lin EY, Jones JH, Dechantsreiter M, Enyedy I, Marcotte D, Xiao G, Li B, Richter K. PMID: 31898999.
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PubMed Mentions:
12 Fields:
Translation:
HumansAnimalsCells
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CDK12-mediated transcriptional regulation of noncanonical NF-κB components is essential for signaling. Sci Signal. 2018 07 31; 11(541).
Henry KL, Kellner D, Bajrami B, Anderson JE, Beyna M, Bhisetti G, Cameron T, Capacci AG, Bertolotti-Ciarlet A, Feng J, Gao B, Hopkins B, Jenkins T, Li K, May-Dracka T, Murugan P, Wei R, Zeng W, Allaire N, Buckler A, Loh C, Juhasz P, Lucas B, Ennis KA, Vollman E, Cahir-McFarland E, Hett EC, Ols ML. PMID: 30065029.
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PubMed Mentions:
12 Fields:
Translation:
HumansCells
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Direct, enantioselective α-alkylation of aldehydes using simple olefins. Nat Chem. 2017 11; 9(11):1073-1077.
Capacci AG, Malinowski JT, McAlpine NJ, Kuhne J, MacMillan DWC. PMID: 29064486; PMCID: PMC5665178.
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30 Fields:
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Cells
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Efficient chiral monophosphorus ligands for asymmetric Suzuki-Miyaura coupling reactions. Org Lett. 2012 May 04; 14(9):2258-61.
Tang W, Patel ND, Xu G, Xu X, Savoie J, Ma S, Hao MH, Keshipeddy S, Capacci AG, Wei X, Zhang Y, Gao JJ, Li W, Rodriguez S, Lu BZ, Yee NK, Senanayake CH. PMID: 22497425.
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PubMed Mentions:
14 Fields:
Translation:
Cells
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Diastereoselective intramolecular Friedel-Crafts alkylation of tetralins. Org Lett. 2011 Jun 17; 13(12):3000-3.
Liébert C, Brinks MK, Capacci AG, Fleming MJ, Lautens M. PMID: 21591612.
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1 Fields:
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A general and special catalyst for Suzuki-Miyaura coupling processes. Angew Chem Int Ed Engl. 2010 Aug 09; 49(34):5879-83.
Tang W, Capacci AG, Wei X, Li W, White A, Patel ND, Savoie J, Gao JJ, Rodriguez S, Qu B, Haddad N, Lu BZ, Krishnamurthy D, Yee NK, Senanayake CH. PMID: 20632427.
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PubMed Mentions:
14 Fields:
Translation:
Cells
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Copper catalyzed asymmetric propargylation of aldehydes. J Am Chem Soc. 2010 Jun 09; 132(22):7600-1.
Fandrick DR, Fandrick KR, Reeves JT, Tan Z, Tang W, Capacci AG, Rodriguez S, Song JJ, Lee H, Yee NK, Senanayake CH. PMID: 20481453.
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PubMed Mentions:
21 Fields:
Translation:
Cells
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Novel and efficient chiral bisphosphorus ligands for rhodium-catalyzed asymmetric hydrogenation. Org Lett. 2010 Mar 05; 12(5):1104-7.
Tang W, Capacci AG, White A, Ma S, Rodriguez S, Qu B, Savoie J, Patel ND, Wei X, Haddad N, Grinberg N, Yee NK, Krishnamurthy D, Senanayake CH. PMID: 20148522.
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PubMed Mentions:
5 Fields:
Translation:
Cells
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Novel, tunable, and efficient chiral bisdihydrobenzooxaphosphole ligands for asymmetric hydrogenation. Org Lett. 2010 Jan 01; 12(1):176-9.
Tang W, Qu B, Capacci AG, Rodriguez S, Wei X, Haddad N, Narayanan B, Ma S, Grinberg N, Yee NK, Krishnamurthy D, Senanayake CH. PMID: 19950894.
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PubMed Mentions:
15 Fields:
Translation:
Cells
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A facile and practical synthesis of N-acetyl enamides. J Org Chem. 2009 Dec 18; 74(24):9528-30.
Tang W, Capacci A, Sarvestani M, Wei X, Yee NK, Senanayake CH. PMID: 19921804.
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PubMed Mentions:
1 Fields:
Translation:
Cells