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David Fox, MD

TitleAssociate Clinical Professor
InstitutionUniversity of California San Francisco
DepartmentDean's Office
Address533 Parnassus Avenue
San Francisco CA 94117
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    Collapse Research 
    Collapse Research Activities and Funding
    Proinflammatory and Autoantigenic Properties of a Novel Citrullinated Form of IL-6 in Rheumatoid Arthritis
    NIH/NIAMS R21AR072931Mar 1, 2018 - Feb 29, 2020
    Role: Principal Investigator
    University of Michigan Autoimmunity Center of Excellence, Clinical Research Progr
    NIH/NIAID UM1AI110557May 1, 2014 - Apr 30, 2019
    Role: Principal Investigator
    University of Michigan Rheumatic Diseases Research Core Center
    NIH/NIAMS P30AR048310Sep 28, 2001 - Jul 31, 2011
    Role: Principal Investigator
    Unique Surface Structures on Synovial Cells
    NIH/NIAMS R01AR038477Aug 1, 1986 - Aug 31, 2012
    Role: Principal Investigator
    UNIQUE SURFACE STRUCTURES ON RHEUMATOID SYNOVIAL T CELLS
    NIH/NIAMS R29AR038477Aug 1, 1986 - Jul 31, 1991
    Role: Principal Investigator
    ARTHRITIS AND MUSCULOSKELETAL DISEASES CENTER
    NIH/NIAMS P60AR020557Sep 20, 1977 - Dec 31, 2002
    Role: Principal Investigator
    Training of Arthritis Research Scientists
    NIH/NIAMS T32AR007080Jul 1, 1976 - Jun 30, 2023
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Zhang C, Xu Y, Chowdhary A, Fox D, Gurney ME, Zhang HT, Auerbach BD, Salvi RJ, Yang M, Li G, O'Donnell JM. Memory enhancing effects of BPN14770, an allosteric inhibitor of phosphodiesterase-4D, in wild-type and humanized mice. Neuropsychopharmacology. 2018 Aug 14. PMID: 30131563.
      View in: PubMed
    2. Mandelin AM, Homan PJ, Shaffer AM, Cuda CM, Dominguez ST, Bacalao E, Carns M, Hinchcliff M, Lee J, Aren K, Thakrar A, Montgomery AB, Bridges SL, Bathon JM, Atkinson JP, Fox DA, Matteson EL, Buckley CD, Pitzalis C, Parks D, Hughes LB, Geraldino-Pardilla L, Ike R, Phillips K, Wright K, Filer A, Kelly S, Ruderman EM, Morgan V, Abdala-Valencia H, Misharin AV, Budinger GS, Bartom ET, Pope RM, Perlman H, Winter DR. Transcriptional Profiling of Synovial Macrophages Using Minimally Invasive Ultrasound-Guided Synovial Biopsies in Rheumatoid Arthritis. Arthritis Rheumatol. 2018 Jun; 70(6):841-854. PMID: 29439295.
      View in: PubMed
    3. Xu J, Zhang L, Xie M, Li Y, Huang P, Saunders TL, Fox DA, Rosenquist R, Lin F. Role of Complement in a Rat Model of Paclitaxel-Induced Peripheral Neuropathy. J Immunol. 2018 Jun 15; 200(12):4094-4101. PMID: 29695418.
      View in: PubMed
    4. Carmona-Rivera C, Bicker KL, Thompson PR, Buckner JH, Robinson WH, Fox DA, Kaplan MJ. Response to comment on "Synovial fibroblast-neutrophil interactions promote pathogenic adaptive immunity in rheumatoid arthritis". Sci Immunol. 2018 Mar 30; 3(21). PMID: 29602804.
      View in: PubMed
    5. Fox DA. The role of CD6 in autoimmune diseases. Cell Mol Immunol. 2018 Mar 23. PMID: 29572546.
      View in: PubMed
    6. Consuegra-Fernández M, Lin F, Fox DA, Lozano F. Clinical and experimental evidence for targeting CD6 in immune-based disorders. Autoimmun Rev. 2018 May; 17(5):493-503. PMID: 29526637.
      View in: PubMed
    7. Zhang L, Li Y, Qiu W, Bell BA, Dvorina N, Baldwin WM, Singer N, Kern T, Caspi RR, Fox DA, Lin F. Targeting CD6 for the treatment of experimental autoimmune uveitis. J Autoimmun. 2018 Jun; 90:84-93. PMID: 29472120.
      View in: PubMed
    8. O'Brien MJ, Shu Q, Stinson WA, Tsou PS, Ruth JH, Isozaki T, Campbell PL, Ohara RA, Koch AE, Fox DA, Amin MA. A unique role for galectin-9 in angiogenesis and inflammatory arthritis. Arthritis Res Ther. 2018 Feb 12; 20(1):31. PMID: 29433546.
      View in: PubMed
    9. Elshabrawy HA, Volin MV, Essani AB, Chen Z, McInnes IB, Van Raemdonck K, Palasiewicz K, Arami S, Gonzalez M, Ashour HM, Kim SJ, Zhou G, Fox DA, Shahrara S. IL-11 facilitates a novel connection between RA joint fibroblasts and endothelial cells. Angiogenesis. 2018 May; 21(2):215-228. PMID: 29327326.
      View in: PubMed
    10. Nagaraja V, Mara C, Khanna PP, Namas R, Young A, Fox DA, Laing T, McCune WJ, Dodge C, Rizzo D, Almackenzie M, Khanna D. Establishing clinical severity for PROMIS® measures in adult patients with rheumatic diseases. Qual Life Res. 2018 Mar; 27(3):755-764. PMID: 28983738.
      View in: PubMed
    11. Totzke J, Gurbani D, Raphemot R, Hughes PF, Bodoor K, Carlson DA, Loiselle DR, Bera AK, Eibschutz LS, Perkins MM, Eubanks AL, Campbell PL, Fox DA, Westover KD, Haystead TAJ, Derbyshire ER. Takinib, a Selective TAK1 Inhibitor, Broadens the Therapeutic Efficacy of TNF-a Inhibition for Cancer and Autoimmune Disease. Cell Chem Biol. 2017 Aug 17; 24(8):1029-1039.e7. PMID: 28820959.
      View in: PubMed
    12. Enyindah-Asonye G, Li Y, Ruth JH, Spassov DS, Hebron KE, Zijlstra A, Moasser MM, Wang B, Singer NG, Cui H, Ohara RA, Rasmussen SM, Fox DA, Lin F. CD318 is a ligand for CD6. Proc Natl Acad Sci U S A. 2017 Aug 15; 114(33):E6912-E6921. PMID: 28760953.
      View in: PubMed
    13. Fechtner S, Fox DA, Ahmed S. Transforming growth factor ß activated kinase 1: a potential therapeutic target for rheumatic diseases. Rheumatology (Oxford). 2017 07 01; 56(7):1060-1068. PMID: 27550296.
      View in: PubMed
    14. Chung KC, Kotsis SV, Burns PB, Burke FD, Wilgis EFS, Fox DA, Kim HM. Seven-Year Outcomes of the Silicone Arthroplasty in Rheumatoid Arthritis Prospective Cohort Study. Arthritis Care Res (Hoboken). 2017 07; 69(7):973-981. PMID: 27696739.
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    15. Asif Amin M, Fox DA, Ruth JH. Synovial cellular and molecular markers in rheumatoid arthritis. Semin Immunopathol. 2017 06; 39(4):385-393. PMID: 28497350.
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    16. Carmona-Rivera C, Carlucci PM, Moore E, Lingampalli N, Uchtenhagen H, James E, Liu Y, Bicker KL, Wahamaa H, Hoffmann V, Catrina AI, Thompson P, Buckner JH, Robinson WH, Fox DA, Kaplan MJ. Synovial fibroblast-neutrophil interactions promote pathogenic adaptive immunity in rheumatoid arthritis. Sci Immunol. 2017 Apr; 2(10). PMID: 28649674.
      View in: PubMed
    17. Hutchings KM, Lisabeth EM, Rajeswaran W, Wilson MW, Sorenson RJ, Campbell PL, Ruth JH, Amin A, Tsou PS, Leipprandt JR, Olson SR, Wen B, Zhao T, Sun D, Khanna D, Fox DA, Neubig RR, Larsen SD. Pharmacokinetic optimitzation of CCG-203971: Novel inhibitors of the Rho/MRTF/SRF transcriptional pathway as potential antifibrotic therapeutics for systemic scleroderma. Bioorg Med Chem Lett. 2017 04 15; 27(8):1744-1749. PMID: 28285914.
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    18. Li Y, Singer NG, Whitbred J, Bowen MA, Fox DA, Lin F. CD6 as a potential target for treating multiple sclerosis. Proc Natl Acad Sci U S A. 2017 03 07; 114(10):2687-2692. PMID: 28209777.
      View in: PubMed
    19. Mor-Vaknin N, Saha A, Legendre M, Carmona-Rivera C, Amin MA, Rabquer BJ, Gonzales-Hernandez MJ, Jorns J, Mohan S, Yalavarthi S, Pai DA, Angevine K, Almburg SJ, Knight JS, Adams BS, Koch AE, Fox DA, Engelke DR, Kaplan MJ, Markovitz DM. DEK-targeting DNA aptamers as therapeutics for inflammatory arthritis. Nat Commun. 2017 Feb 06; 8:14252. PMID: 28165452.
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    20. Elshabrawy HA, Essani AE, Szekanecz Z, Fox DA, Shahrara S. TLRs, future potential therapeutic targets for RA. Autoimmun Rev. 2017 Feb; 16(2):103-113. PMID: 27988432.
      View in: PubMed
    21. Tsou PS, Wren JD, Amin MA, Schiopu E, Fox DA, Khanna D, Sawalha AH. Histone Deacetylase 5 Is Overexpressed in Scleroderma Endothelial Cells and Impairs Angiogenesis via Repression of Proangiogenic Factors. Arthritis Rheumatol. 2016 12; 68(12):2975-2985. PMID: 27482699.
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    22. Morgan RL, Behbahani-Nejad N, Endres J, Amin MA, Lepore NJ, Du Y, Urquhart A, Chung KC, Fox DA. Localization, Shedding, Regulation and Function of Aminopeptidase N/CD13 on Fibroblast like Synoviocytes. PLoS One. 2016; 11(9):e0162008. PMID: 27658265.
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    23. Edhayan G, Ohara RA, Stinson WA, Amin MA, Isozaki T, Ha CM, Haines GK, Morgan R, Campbell PL, Arbab AS, Friday SC, Fox DA, Ruth JH. Inflammatory properties of inhibitor of DNA binding 1 secreted by synovial fibroblasts in rheumatoid arthritis. Arthritis Res Ther. 2016 Apr 12; 18:87. PMID: 27071670; PMCID: PMC4830090.
    24. Friday SC, Fox DA. Phospholipase D enzymes facilitate IL-17- and TNFa-induced expression of proinflammatory genes in rheumatoid arthritis synovial fibroblasts (RASF). Immunol Lett. 2016 06; 174:9-18. PMID: 27058440.
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    25. Tsou PS, Amin MA, Campbell PL, Zakhem G, Balogh B, Edhayan G, Ohara RA, Schiopu E, Khanna D, Koch AE, Fox DA. Activation of the Thromboxane A2 Receptor by 8-Isoprostane Inhibits the Pro-Angiogenic Effect of Vascular Endothelial Growth Factor in Scleroderma. J Invest Dermatol. 2015 Dec; 135(12):3153-3162. PMID: 26288351; PMCID: PMC4648660.
    26. Fox DA. Citrullination: A Specific Target for the Autoimmune Response in Rheumatoid Arthritis. J Immunol. 2015 Jul 01; 195(1):5-7. PMID: 26092811.
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    27. Lundy SK, Klinker MW, Fox DA. Killer B lymphocytes and their fas ligand positive exosomes as inducers of immune tolerance. Front Immunol. 2015; 6:122. PMID: 25852690; PMCID: PMC4367442.
    28. Waljee J, Zhong L, Baser O, Yuce H, Fox DA, Chung KC. The incidence of upper and lower extremity surgery for rheumatoid arthritis among Medicare beneficiaries. J Bone Joint Surg Am. 2015 Mar 04; 97(5):403-10. PMID: 25740031; PMCID: PMC4344595.
    29. Mukai T, Gallant R, Ishida S, Kittaka M, Yoshitaka T, Fox DA, Morita Y, Nishida K, Rottapel R, Ueki Y. Loss of SH3 domain-binding protein 2 function suppresses bone destruction in tumor necrosis factor-driven and collagen-induced arthritis in mice. Arthritis Rheumatol. 2015 Mar; 67(3):656-67. PMID: 25470448; PMCID: PMC4342302.
    30. Zhong L, Chung KC, Baser O, Fox DA, Yuce H, Waljee JF. Variation in rheumatoid hand and wrist surgery among medicare beneficiaries: a population-based cohort study. J Rheumatol. 2015 Mar; 42(3):429-36. PMID: 25593243; PMCID: PMC4827611.
    31. Morgan R, Endres J, Behbahani-Nejad N, Phillips K, Ruth JH, Friday SC, Edhayan G, Lanigan T, Urquhart A, Chung KC, Fox DA. Expression and function of aminopeptidase N/CD13 produced by fibroblast-like synoviocytes in rheumatoid arthritis: role of CD13 in chemotaxis of cytokine-activated T cells independent of enzymatic activity. Arthritis Rheumatol. 2015 Jan; 67(1):74-85. PMID: 25219368; PMCID: PMC4280337.
    32. Fox DA. Current and future approaches to the treatment of immunologic diseases: new targets and new therapeutic agents. Transl Res. 2015 Feb; 165(2):251-4. PMID: 25468483.
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    33. Chung KC, Nellans KW, Burns PB, Wilgis EF, Burke FD, Fox DA, Kim HM. Patient expectations and long-term outcomes in rheumatoid arthritis patients: results from the SARA (Silicone Arthroplasty in Rheumatoid Arthritis) study. Clin Rheumatol. 2015 Apr; 34(4):641-51. PMID: 25267562; PMCID: PMC4374599.
    34. Mukai T, Gallant R, Ishida S, Yoshitaka T, Kittaka M, Nishida K, Fox DA, Morita Y, Ueki Y. SH3BP2 gain-of-function mutation exacerbates inflammation and bone loss in a murine collagen-induced arthritis model. PLoS One. 2014; 9(8):e105518. PMID: 25144740; PMCID: PMC4140794.
    35. Hagen TJ, Mo X, Burgin AB, Fox D, Zhang Z, Gurney ME. Discovery of triazines as selective PDE4B versus PDE4D inhibitors. Bioorg Med Chem Lett. 2014 Aug 15; 24(16):4031-4. PMID: 24998378; PMCID: PMC4142572.
    36. Dennis G, Holweg CT, Kummerfeld SK, Choy DF, Setiadi AF, Hackney JA, Haverty PM, Gilbert H, Lin WY, Diehl L, Fischer S, Song A, Musselman D, Klearman M, Gabay C, Kavanaugh A, Endres J, Fox DA, Martin F, Townsend MJ. Synovial phenotypes in rheumatoid arthritis correlate with response to biologic therapeutics. Arthritis Res Ther. 2014; 16(2):R90. PMID: 25167216; PMCID: PMC4060385.
    37. Haak AJ, Tsou PS, Amin MA, Ruth JH, Campbell P, Fox DA, Khanna D, Larsen SD, Neubig RR. Targeting the myofibroblast genetic switch: inhibitors of myocardin-related transcription factor/serum response factor-regulated gene transcription prevent fibrosis in a murine model of skin injury. J Pharmacol Exp Ther. 2014 Jun; 349(3):480-6. PMID: 24706986; PMCID: PMC4019321.
    38. Fox D, Yan Z, Ling C, Zhao Y, Lee DY, Fukagawa T, Yang W, Wang W. The histone-fold complex MHF is remodeled by FANCM to recognize branched DNA and protect genome stability. Cell Res. 2014 May; 24(5):560-75. PMID: 24699063; PMCID: PMC4011343.
    39. Klinker MW, Lizzio V, Reed TJ, Fox DA, Lundy SK. Human B Cell-Derived Lymphoblastoid Cell Lines Constitutively Produce Fas Ligand and Secrete MHCII(+)FasL(+) Killer Exosomes. Front Immunol. 2014; 5:144. PMID: 24765093; PMCID: PMC3980107.
    40. Gizinski AM, Fox DA. T cell subsets and their role in the pathogenesis of rheumatic disease. Curr Opin Rheumatol. 2014 Mar; 26(2):204-10. PMID: 24445478.
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    41. Tsou PS, Balogh B, Pinney AJ, Zakhem G, Lozier A, Amin MA, Stinson WA, Schiopu E, Khanna D, Fox DA, Koch AE. Lipoic acid plays a role in scleroderma: insights obtained from scleroderma dermal fibroblasts. Arthritis Res Ther. 2014; 16(5):411. PMID: 25123250; PMCID: PMC4558991.
    42. Kitko CL, Levine JE, Storer BE, Chai X, Fox DA, Braun TM, Couriel DR, Martin PJ, Flowers ME, Hansen JA, Chang L, Conlon M, Fiema BJ, Morgan R, Pongtornpipat P, Lamiman K, Ferrara JL, Lee SJ, Paczesny S. Plasma CXCL9 elevations correlate with chronic GVHD diagnosis. Blood. 2014 Jan 30; 123(5):786-93. PMID: 24363401.
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    43. Cottier KE, Fogle EM, Fox DA, Ahmed S. Noxa in rheumatic diseases: present understanding and future impact. Rheumatology (Oxford). 2014 Sep; 53(9):1539-46. PMID: 24352336; PMCID: PMC4135581.
    44. Gladue HS, Fox DA. Voriconazole-induced periostitis causing arthralgias mimicking a flare of granulomatosis with polyangiitis. J Clin Rheumatol. 2013 Dec; 19(8):444-5. PMID: 24263147.
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    45. Marchesan JT, Gerow EA, Schaff R, Taut AD, Shin SY, Sugai J, Brand D, Burberry A, Jorns J, Lundy SK, Nuñez G, Fox DA, Giannobile WV. Porphyromonas gingivalis oral infection exacerbates the development and severity of collagen-induced arthritis. Arthritis Res Ther. 2013 Nov 12; 15(6):R186. PMID: 24456966; PMCID: PMC3979094.
    46. Chetta M, Burns PB, Kim HM, Burke FD, Wilgis EF, Fox DA, Chung KC. The effect of swan neck and boutonniere deformities on the outcome of silicone metacarpophalangeal joint arthroplasty in rheumatoid arthritis. Plast Reconstr Surg. 2013 Sep; 132(3):597-603. PMID: 23985634; PMCID: PMC4153347.
    47. Klinker MW, Reed TJ, Fox DA, Lundy SK. Interleukin-5 supports the expansion of fas ligand-expressing killer B cells that induce antigen-specific apoptosis of CD4(+) T cells and secrete interleukin-10. PLoS One. 2013; 8(8):e70131. PMID: 23940537; PMCID: PMC3734024.
    48. Xu D, Shen W, Guo R, Xue Y, Peng W, Sima J, Yang J, Sharov A, Srikantan S, Yang J, Fox D, Qian Y, Martindale JL, Piao Y, Machamer J, Joshi SR, Mohanty S, Shaw AC, Lloyd TE, Brown GW, Ko MS, Gorospe M, Zou S, Wang W. Top3ß is an RNA topoisomerase that works with fragile X syndrome protein to promote synapse formation. Nat Neurosci. 2013 Sep; 16(9):1238-47. PMID: 23912945.
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    49. Kim HM, Burns PB, Fox DA, Chung KC, Burke FD, Wilgis EF. Metacarpophalangeal implant surgery: time for a randomized clinical trial? Reply. Arthritis Care Res (Hoboken). 2013 Jun; 65(6):1014-5. PMID: 23335429.
      View in: PubMed
    50. Khandpur R, Carmona-Rivera C, Vivekanandan-Giri A, Gizinski A, Yalavarthi S, Knight JS, Friday S, Li S, Patel RM, Subramanian V, Thompson P, Chen P, Fox DA, Pennathur S, Kaplan MJ. NETs are a source of citrullinated autoantigens and stimulate inflammatory responses in rheumatoid arthritis. Sci Transl Med. 2013 Mar 27; 5(178):178ra40. PMID: 23536012; PMCID: PMC3727661.
    51. Ling S, Cline EN, Haug TS, Fox DA, Holoshitz J. Citrullinated calreticulin potentiates rheumatoid arthritis shared epitope signaling. Arthritis Rheum. 2013 Mar; 65(3):618-26. PMID: 23233327; PMCID: PMC3582785.
    52. Kato H, Endres J, Fox DA. The roles of IFN-? versus IL-17 in pathogenic effects of human Th17 cells on synovial fibroblasts. Mod Rheumatol. 2013 Nov; 23(6):1140-50. PMID: 23306426; PMCID: PMC3710715.
    53. Cooney LA, Fox DA. Regulation of Th17 maturation by interleukin 4. Crit Rev Immunol. 2013; 33(5):379-87. PMID: 24099299.
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    54. Kovacs D, Torralba KD, Fox DA, Solomon DH, Panush RS. Reflecting on early arthritis. J Rheumatol. 2012 Nov; 39(11):2059-61. PMID: 23118276.
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    55. Chung KC, Burns PB, Kim HM, Burke FD, Wilgis EF, Fox DA. Long-term followup for rheumatoid arthritis patients in a multicenter outcomes study of silicone metacarpophalangeal joint arthroplasty. Arthritis Care Res (Hoboken). 2012 Sep; 64(9):1292-300. PMID: 22511483; PMCID: PMC3422446.
    56. Fox DA. Kinase inhibition--a new approach to the treatment of rheumatoid arthritis. N Engl J Med. 2012 Aug 09; 367(6):565-7. PMID: 22873537.
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    57. Fox DA. Treg cells to the rescue. Arthritis Rheum. 2012 Aug; 64(8):2426-8. PMID: 22605657.
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    58. Yan Z, Guo R, Paramasivam M, Shen W, Ling C, Fox D, Wang Y, Oostra AB, Kuehl J, Lee DY, Takata M, Hoatlin ME, Schindler D, Joenje H, de Winter JP, Li L, Seidman MM, Wang W. A ubiquitin-binding protein, FAAP20, links RNF8-mediated ubiquitination to the Fanconi anemia DNA repair network. Mol Cell. 2012 Jul 13; 47(1):61-75. PMID: 22705371.
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    59. Panush RS, Quismorio FP, Fox DA. Epilogue: how will we care for patients with early arthritis? Rheum Dis Clin North Am. 2012 May; 38(2):427-9. PMID: 22819093.
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    60. Cooney LA, Towery K, Endres J, Fox DA. Sensitivity and resistance to regulation by IL-4 during Th17 maturation. J Immunol. 2011 Nov 01; 187(9):4440-50. PMID: 21949021; PMCID: PMC3197869.
    61. Chung KC, Burns PB, Reichert HA, Fox DA, Burke FD, Wilgis EF, Regan M, Kim HM. Properties of the International Classification for Functioning, Disability and Health in assessing hand outcomes in patients with rheumatoid arthritis. J Rehabil Med. 2011 Mar; 43(4):292-8. PMID: 21267527.
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    62. Wallis SK, Cooney LA, Endres JL, Lee MJ, Ryu J, Somers EC, Fox DA. A polymorphism in the interleukin-4 receptor affects the ability of interleukin-4 to regulate Th17 cells: a possible immunoregulatory mechanism for genetic control of the severity of rheumatoid arthritis. Arthritis Res Ther. 2011 Feb 04; 13(1):R15. PMID: 21294892; PMCID: PMC3241359.
    63. Entezami P, Fox DA, Clapham PJ, Chung KC. Historical perspective on the etiology of rheumatoid arthritis. Hand Clin. 2011 Feb; 27(1):1-10. PMID: 21176794; PMCID: PMC3119866.
    64. Kahlenberg JM, Fox DA. Advances in the medical treatment of rheumatoid arthritis. Hand Clin. 2011 Feb; 27(1):11-20. PMID: 21176795; PMCID: PMC3135413.
    65. Kato H, Fox DA. Are Th17 cells an appropriate new target in the treatment of rheumatoid arthritis? Clin Transl Sci. 2010 Dec; 3(6):319-26. PMID: 21167010; PMCID: PMC3057561.
    66. Xu D, Muniandy P, Leo E, Yin J, Thangavel S, Shen X, Ii M, Agama K, Guo R, Fox D, Meetei AR, Wilson L, Nguyen H, Weng NP, Brill SJ, Li L, Vindigni A, Pommier Y, Seidman M, Wang W. Rif1 provides a new DNA-binding interface for the Bloom syndrome complex to maintain normal replication. EMBO J. 2010 Sep 15; 29(18):3140-55. PMID: 20711169; PMCID: PMC2944062.
    67. Gizinski AM, Fox DA, Sarkar S. Pharmacotherapy: concepts of pathogenesis and emerging treatments. Co-stimulation and T cells as therapeutic targets. Best Pract Res Clin Rheumatol. 2010 Aug; 24(4):463-77. PMID: 20732645; PMCID: PMC3146352.
    68. Waljee JF, Chung KC, Kim HM, Burns PB, Burke FD, Wilgis EF, Fox DA. Validity and responsiveness of the Michigan Hand Questionnaire in patients with rheumatoid arthritis: a multicenter, international study. Arthritis Care Res (Hoboken). 2010 Nov; 62(11):1569-77. PMID: 20521331; PMCID: PMC4386867.
    69. Sakuta T, Morita Y, Satoh M, Fox DA, Kashihara N. Involvement of the renin-angiotensin system in the development of vascular damage in a rat model of arthritis: effect of angiotensin receptor blockers. Arthritis Rheum. 2010 May; 62(5):1319-28. PMID: 20213806.
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    70. Fox DA, Gizinski A, Morgan R, Lundy SK. Cell-cell interactions in rheumatoid arthritis synovium. Rheum Dis Clin North Am. 2010 May; 36(2):311-23. PMID: 20510236; PMCID: PMC2879397.
    71. Fox DA. Preface: rheumatoid arthritis--halfway there. Rheum Dis Clin North Am. 2010 May; 36(2):xiii-xiv. PMID: 20510230.
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    72. Sarkar S, Fox DA. Targeting IL-17 and Th17 cells in rheumatoid arthritis. Rheum Dis Clin North Am. 2010 May; 36(2):345-66. PMID: 20510238.
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    73. Chung KC, Kotsis SV, Fox DA, Regan M, Burke FD, Wilgis EF, Kim HM. Differences between the United States and the United Kingdom in the treatment of rheumatoid arthritis: analyses from a hand arthroplasty trial. Clin Rheumatol. 2010 Apr; 29(4):363-7. PMID: 20077124; PMCID: PMC4386876.
    74. Islam MN, Fox D, Guo R, Enomoto T, Wang W. RecQL5 promotes genome stabilization through two parallel mechanisms--interacting with RNA polymerase II and acting as a helicase. Mol Cell Biol. 2010 May; 30(10):2460-72. PMID: 20231364; PMCID: PMC2863711.
    75. Chung KC, Kotsis SV, Wilgis EF, Fox DA, Regan M, Kim HM, Burke FD. Outcomes of silicone arthroplasty for rheumatoid metacarpophalangeal joints stratified by fingers. J Hand Surg Am. 2009 Nov; 34(9):1647-52. PMID: 19896008; PMCID: PMC4413434.
    76. Sarkar S, Cooney LA, White P, Dunlop DB, Endres J, Jorns JM, Wasco MJ, Fox DA. Regulation of pathogenic IL-17 responses in collagen-induced arthritis: roles of endogenous interferon-gamma and IL-4. Arthritis Res Ther. 2009; 11(5):R158. PMID: 19852819; PMCID: PMC2787258.
    77. Lundy SK, Fox DA. Reduced Fas ligand-expressing splenic CD5+ B lymphocytes in severe collagen-induced arthritis. Arthritis Res Ther. 2009; 11(4):R128. PMID: 19706160; PMCID: PMC2745812.
    78. Chung KC, Burke FD, Wilgis EF, Regan M, Kim HM, Fox DA. A prospective study comparing outcomes after reconstruction in rheumatoid arthritis patients with severe ulnar drift deformities. Plast Reconstr Surg. 2009 Jun; 123(6):1769-77. PMID: 19483578; PMCID: PMC2735852.
    79. Chung KC, Burns PB, Wilgis EF, Burke FD, Regan M, Kim HM, Fox DA. A multicenter clinical trial in rheumatoid arthritis comparing silicone metacarpophalangeal joint arthroplasty with medical treatment. J Hand Surg Am. 2009 May-Jun; 34(5):815-23. PMID: 19410984; PMCID: PMC4381953.
    80. Fox DA. The future of ILAR. Clin Rheumatol. 2009 May; 28(5):493-4. PMID: 19252816.
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    81. Fox DA. Unity in the field of rheumatology: the role of the ACR. Arthritis Rheum. 2009 Feb; 60(2):313-6. PMID: 19180505.
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    82. Ognenovski VM, Ojo TC, Fox DA. Etanercept-associated pulmonary granulomatous inflammation in patients with rheumatoid arthritis. J Rheumatol. 2008 Nov; 35(11):2279-82. PMID: 19004058.
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    83. Sarkar S, Fox DA. Regulatory T cells in rheumatoid arthritis. Curr Rheumatol Rep. 2008 Oct; 10(5):405-12. PMID: 18817646.
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    84. Yuling H, Ruijing X, Xiang J, Yanping J, Lang C, Li L, Dingping Y, Xinti T, Jingyi L, Zhiqing T, Yongyi B, Bing X, Xinxing W, Youxin J, Fox DA, Lundy SK, Guohua D, Jinquan T. CD19+CD5+ B cells in primary IgA nephropathy. J Am Soc Nephrol. 2008 Nov; 19(11):2130-9. PMID: 18650480; PMCID: PMC2573008.
    85. Tesmer LA, Lundy SK, Sarkar S, Fox DA. Th17 cells in human disease. Immunol Rev. 2008 Jun; 223:87-113. PMID: 18613831; PMCID: PMC3299089.
    86. Estes DJ, Memarsadeghi S, Lundy SK, Marti F, Mikol DD, Fox DA, Mayer M. High-throughput profiling of ion channel activity in primary human lymphocytes. Anal Chem. 2008 May 15; 80(10):3728-35. PMID: 18433147.
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