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William Seaman, MD

Title(s)Professor, Medicine
SchoolSchool of Medicine
Address533 Parnassus Avenue
San Francisco CA 94117
Phone415-514-0732
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    Collapse Biography 
    Collapse Education and Training
    Harvard Medical School, BostonMD1969Medicine
    University of California, San Francisco, CA2018Diversity, Equity, and Inclusion Champion Training

    Collapse Research 
    Collapse Research Activities and Funding
    Role of the Tim-2 Receptor in Immunity and Autoimmunity
    NIH/NIAID R01AI061164Jul 1, 2005 - Mar 31, 2010
    Role: Principal Investigator
    SHPS-1 As a Regulator of Innate Immunity in Arthritis
    NIH/NIAMS R21AR051751Sep 1, 2004 - Aug 31, 2006
    Role: Principal Investigator
    Biology of a New DAP12 Associated Receptor Family
    NIH/NCI R01CA087922May 1, 2001 - Mar 31, 2008
    Role: Principal Investigator
    Alliance for Cellular Signaling
    NIH U54GM062114Sep 1, 2000 - Aug 31, 2008
    Role: Co-Investigator
    TRANSMEMBRANE SIGNALING BY LY-49
    NIH/NCI R01CA069299Jul 1, 1996 - Jun 30, 2000
    Role: Principal Investigator
    TRANSMEMBRANE SIGNALING IN THE ACTIVATION OF NK CELLS
    NIH/NCI R01CA046812Feb 1, 1988 - Jan 31, 1997
    Role: Principal Investigator
    MULTIPURPOSE ARTHRITIS AND MUSCULOSKELETAL DISEASES CTR
    NIH/NIAMS P60AR020684Apr 1, 1986 - Dec 31, 2003
    Role: Co-Principal Investigator
    INTESTINAL IMMUNE RESPONSE: REGULATION AND MECHANISMS
    NIH P01AM033004Dec 1, 1983 - Nov 30, 1986
    Role: Co-Investigator
    OXIDATIVE REGULATION OF HUMAN NATURAL KILLER CELLS
    NIH/NCI R01CA034529Jun 1, 1983 - May 31, 1986
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Georgia Abortion Law and Our Commitment to Patients. Arthritis Rheumatol. 2020 02; 72(2):377-378. Craft JE, Crow MK, Lockshin MD, Salmon JE, Diamond B, Elkon KB, Flood J, Fox DA, Gabriel SE, Gilkeson GS, Hahn BH, Hardin J, Koopman WJ, Seaman WE, Wofsy D, Sergent JS, Uknis AB, Weinblatt ME. PMID: 31637878.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    2. New blood: Creative funding of disease-specific research. Sci Transl Med. 2015 May 20; 7(288):288ed5. Seaman WE, Locksley RM, Welsh MJ. PMID: 25995219.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    3. Traumatic brain injury induces macrophage subsets in the brain. Eur J Immunol. 2013 Aug; 43(8):2010-22. Hsieh CL, Kim CC, Ryba BE, Niemi EC, Bando JK, Locksley RM, Liu J, Nakamura MC, Seaman WE. PMID: 23630120.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    4. Iron uptake mediated by binding of H-ferritin to the TIM-2 receptor in mouse cells. PLoS One. 2011; 6(8):e23800. Han J, Seaman WE, Di X, Wang W, Willingham M, Torti FM, Torti SV. PMID: 21886823.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    5. Synergistic Ca2+ responses by G{alpha}i- and G{alpha}q-coupled G-protein-coupled receptors require a single PLC{beta} isoform that is sensitive to both G{beta}{gamma} and G{alpha}q. J Biol Chem. 2011 Jan 14; 286(2):942-51. Rebres RA, Roach TI, Fraser ID, Philip F, Moon C, Lin KM, Liu J, Santat L, Cheadle L, Ross EM, Simon MI, Seaman WE. PMID: 21036901.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    6. Clostridium difficile toxin B differentially affects GPCR-stimulated Ca2+ responses in macrophages: independent roles for Rho and PLA2. J Leukoc Biol. 2010 Jun; 87(6):1041-57. Rebres RA, Moon C, Decamp D, Lin KM, Fraser ID, Milne SB, Roach TI, Brown HA, Seaman WE. PMID: 20200401.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    7. Binding and uptake of H-ferritin are mediated by human transferrin receptor-1. Proc Natl Acad Sci U S A. 2010 Feb 23; 107(8):3505-10. Li L, Fang CJ, Ryan JC, Niemi EC, Lebrón JA, Björkman PJ, Arase H, Torti FM, Torti SV, Nakamura MC, Seaman WE. PMID: 20133674.
      View in: PubMed   Mentions: 73     Fields:    Translation:HumansCells
    8. A role for TREM2 ligands in the phagocytosis of apoptotic neuronal cells by microglia. J Neurochem. 2009 May; 109(4):1144-56. Hsieh CL, Koike M, Spusta SC, Niemi EC, Yenari M, Nakamura MC, Seaman WE. PMID: 19302484.
      View in: PubMed   Mentions: 133     Fields:    Translation:AnimalsCells
    9. TREM-2 (triggering receptor expressed on myeloid cells 2) is a phagocytic receptor for bacteria. Journal of Experimental Medicine. 2009 Feb 16; 206(2):i3-i3. Elsa-Noah N'Diaye, Catherine S. Branda, Steven S. Branda, Lisette Nevarez, Marco Colonna, Clifford Lowell, Jessica A. Hamerman, William E. Seaman. .
      View in: Publisher Site   Mentions:
    10. TREM-2 (triggering receptor expressed on myeloid cells 2) is a phagocytic receptor for bacteria. J Cell Biol. 2009 Jan 26; 184(2):215-23. N'Diaye EN, Branda CS, Branda SS, Nevarez L, Colonna M, Lowell C, Hamerman JA, Seaman WE. PMID: 19171755.
      View in: PubMed   Mentions: 76     Fields:    Translation:AnimalsCells
    11. Tim-2 is the receptor for H-ferritin on oligodendrocytes. J Neurochem. 2008 Dec; 107(6):1495-505. Todorich B, Zhang X, Slagle-Webb B, Seaman WE, Connor JR. PMID: 19014383.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    12. Signaling and cross-talk by C5a and UDP in macrophages selectively use PLCbeta3 to regulate intracellular free calcium. J Biol Chem. 2008 Jun 20; 283(25):17351-61. Roach TI, Rebres RA, Fraser ID, Decamp DL, Lin KM, Sternweis PC, Simon MI, Seaman WE. PMID: 18411281.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    13. The innate immune response to Salmonella enterica serovar Typhimurium by macrophages is dependent on TREM2-DAP12. Infect Immun. 2008 Jun; 76(6):2439-47. Charles JF, Humphrey MB, Zhao X, Quarles E, Nakamura MC, Aderem A, Seaman WE, Smith KD. PMID: 18391000.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    14. A single lentiviral vector platform for microRNA-based conditional RNA interference and coordinated transgene expression. Proc Natl Acad Sci U S A. 2006 Sep 12; 103(37):13759-64. Shin KJ, Wall EA, Zavzavadjian JR, Santat LA, Liu J, Hwang JI, Rebres R, Roach T, Seaman W, Simon MI, Fraser ID. PMID: 16945906.
      View in: PubMed   Mentions: 144     Fields:    Translation:AnimalsCells
    15. Cutting edge: inhibition of TLR and FcR responses in macrophages by triggering receptor expressed on myeloid cells (TREM)-2 and DAP12. J Immunol. 2006 Aug 15; 177(4):2051-5. Hamerman JA, Jarjoura JR, Humphrey MB, Nakamura MC, Seaman WE, Lanier LL. PMID: 16887962.
      View in: PubMed   Mentions: 148     Fields:    Translation:AnimalsCells
    16. TREM2, a DAP12-associated receptor, regulates osteoclast differentiation and function. J Bone Miner Res. 2006 Feb; 21(2):237-45. Humphrey MB, Daws MR, Spusta SC, Niemi EC, Torchia JA, Lanier LL, Seaman WE, Nakamura MC. PMID: 16418779.
      View in: PubMed   Mentions: 52     Fields:    Translation:AnimalsCells
    17. Clinical academic rheumatology: comment on the article by Wickersham et al. Arthritis Rheum. 2005 Oct 15; 53(5):800; author reply 800-1. Seaman WE. PMID: 16208663.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    18. TIM-2 is expressed on B cells and in liver and kidney and is a receptor for H-ferritin endocytosis. J Exp Med. 2005 Oct 03; 202(7):955-65. Chen TT, Li L, Chung DH, Allen CD, Torti SV, Torti FM, Cyster JG, Chen CY, Brodsky FM, Niemi EC, Nakamura MC, Seaman WE, Daws MR. PMID: 16203866.
      View in: PubMed   Mentions: 70     Fields:    Translation:AnimalsCells
    19. Analysis of the major patterns of B cell gene expression changes in response to short-term stimulation with 33 single ligands. J Immunol. 2004 Dec 15; 173(12):7141-9. Zhu X, Hart R, Chang MS, Kim JW, Lee SY, Cao YA, Mock D, Ke E, Saunders B, Alexander A, Grossoehme J, Lin KM, Yan Z, Hsueh R, Lee J, Scheuermann RH, Fruman DA, Seaman W, Subramaniam S, Sternweis P, Simon MI, Choi S. PMID: 15585835.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    20. Expression and activation of signal regulatory protein alpha on astrocytomas. Cancer Res. 2004 Jan 01; 64(1):117-27. Chen TT, Brown EJ, Huang EJ, Seaman WE. PMID: 14729615.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    21. CMRF-35-like molecule-1, a novel mouse myeloid receptor, can inhibit osteoclast formation. J Immunol. 2003 Dec 15; 171(12):6541-8. Chung DH, Humphrey MB, Nakamura MC, Ginzinger DG, Seaman WE, Daws MR. PMID: 14662855.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    22. Pattern recognition by TREM-2: binding of anionic ligands. J Immunol. 2003 Jul 15; 171(2):594-9. Daws MR, Sullam PM, Niemi EC, Chen TT, Tchao NK, Seaman WE. PMID: 12847223.
      View in: PubMed   Mentions: 82     Fields:    Translation:HumansAnimalsCells
    23. Overview of the Alliance for Cellular Signaling. Nature. 2002 Dec 12; 420(6916):703-6. Gilman AG, Simon MI, Bourne HR, Harris BA, Long R, Ross EM, Stull JT, Taussig R, Bourne HR, Arkin AP, Cobb MH, Cyster JG, Devreotes PN, Ferrell JE, Fruman D, Gold M, Weiss A, Stull JT, Berridge MJ, Cantley LC, Catterall WA, Coughlin SR, Olson EN, Smith TF, Brugge JS, Botstein D, Dixon JE, Hunter T, Lefkowitz RJ, Pawson AJ, Sternberg PW, Varmus H, Subramaniam S, Sinkovits RS, Li J, Mock D, Ning Y, Saunders B, Sternweis PC, Hilgemann D, Scheuermann RH, DeCamp D, Hsueh R, Lin KM, Ni Y, Seaman WE, Simpson PC, O'Connell TD, Roach T, Simon MI, Choi S, Eversole-Cire P, Fraser I, Mumby MC, Zhao Y, Brekken D, Shu H, Meyer T, Chandy G, Heo WD, Liou J, O'Rourke N, Verghese M, Mumby SM, Han H, Brown HA, Forrester JS, Ivanova P, Milne SB, Casey PJ, Harden TK, Arkin AP, Doyle J, Gray ML, Meyer T, Michnick S, Schmidt MA, Toner M, Tsien RY, Natarajan M, Ranganathan R, Sambrano GR. PMID: 12478301.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    24. Characterization of TREM-3, an activating receptor on mouse macrophages: definition of a family of single Ig domain receptors on mouse chromosome 17. Eur J Immunol. 2002 01; 32(1):59-66. Chung DH, Seaman WE, Daws MR. PMID: 11754004.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    25. Ligand interactions by activating and inhibitory Ly-49 receptors. Immunol Rev. 2001 Jun; 181:138-48. Nakamura MC, Seaman WE. PMID: 11513135.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    26. Cloning and characterization of a novel mouse myeloid DAP12-associated receptor family. Eur J Immunol. 2001 Mar; 31(3):783-91. Daws MR, Lanier LL, Seaman WE, Ryan JC. PMID: 11241283.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimalsCells
    27. Activating Ly-49D and inhibitory Ly-49A natural killer cell receptors demonstrate distinct requirements for interaction with H2-D(d). J Exp Med. 2000 Aug 07; 192(3):447-54. Nakamura MC, Hayashi S, Niemi EC, Ryan JC, Seaman WE. PMID: 10934233.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    28. Natural killer cells and natural killer T cells. Arthritis Rheum. 2000 Jun; 43(6):1204-17. Seaman WE. PMID: 10857779.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    29. Natural killing of xenogeneic cells mediated by the mouse Ly-49D receptor. J Immunol. 1999 Nov 01; 163(9):4694-700. Nakamura MC, Naper C, Niemi EC, Spusta SC, Rolstad B, Butcher GW, Seaman WE, Ryan JC. PMID: 10528166.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    30. Mouse Ly-49D recognizes H-2Dd and activates natural killer cell cytotoxicity. J Exp Med. 1999 Feb 01; 189(3):493-500. Nakamura MC, Linnemeyer PA, Niemi EC, Mason LH, Ortaldo JR, Ryan JC, Seaman WE. PMID: 9927511.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    31. DAP12-mediated signal transduction in natural killer cells. A dominant role for the Syk protein-tyrosine kinase. J Biol Chem. 1998 Dec 04; 273(49):32934-42. McVicar DW, Taylor LS, Gosselin P, Willette-Brown J, Mikhael AI, Geahlen RL, Nakamura MC, Linnemeyer P, Seaman WE, Anderson SK, Ortaldo JR, Mason LH. PMID: 9830044.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansAnimalsCells
    32. The alpha2 domain of H-2Dd restricts the allelic specificity of the murine NK cell inhibitory receptor Ly-49A. J Immunol. 1998 Jun 15; 160(12):5971-8. Sundbäck J, Nakamura MC, Waldenström M, Niemi EC, Seaman WE, Ryan JC, Kärre K. PMID: 9637511.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    33. Natural killer cells and recognition of MHC class I molecules: new perspectives and challenges in immunology. Scand J Immunol. 1998 May; 47(5):412-25. Rolstad B, Seaman WE. PMID: 9627124.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    34. Mouse Ly-49A interrupts early signaling events in natural killer cell cytotoxicity and functionally associates with the SHP-1 tyrosine phosphatase. J Exp Med. 1997 Feb 17; 185(4):673-84. Nakamura MC, Niemi EC, Fisher MJ, Shultz LD, Seaman WE, Ryan JC. PMID: 9034146.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    35. Divergent functions of lectin-like receptors on NK cells. Immunol Rev. 1997 Feb; 155:79-89. Ryan JC, Seaman WE. PMID: 9059884.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    36. Recognition and Signaling by Mouse Ly-49 Receptors. Molecular Basis of NK Cell Recognition and Function. 1996 Oct 2; 64:19-27. William E. Seaman, Brian Daniels, Jay Ryan, Mary Nakamura, Eréne Niemi. .
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    37. An autosomal dominant locus, Nka, mapping to the Ly-49 region of a rat natural killer (NK) gene complex, controls NK cell lysis of allogeneic lymphocytes. J Exp Med. 1996 May 01; 183(5):2197-207. Dissen E, Ryan JC, Seaman WE, Fossum S. PMID: 8642329.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    38. Recognition and signaling by mouse Ly-49 receptors. Chem Immunol. 1996; 64:19-27. Seaman WE, Daniels B, Ryan J, Nakamura M, Niemi E. PMID: 8942069.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    39. NKR-P1A is a target-specific receptor that activates natural killer cell cytotoxicity. J Exp Med. 1995 May 01; 181(5):1911-5. Ryan JC, Niemi EC, Nakamura MC, Seaman WE. PMID: 7722466.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    40. A family of murine NK cell receptors specific for target cell MHC class I molecules. Semin Immunol. 1995 Apr; 7(2):89-101. Yokoyama WM, Daniels BF, Seaman WE, Hunziker R, Margulies DH, Smith HR. PMID: 7579199.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    41. Ly-49A, a receptor for H-2Dd, has a functional carbohydrate recognition domain. Immunity. 1994 Dec; 1(9):785-92. Daniels BF, Nakamura MC, Rosen SD, Yokoyama WM, Seaman WE. PMID: 7895167.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    42. A natural killer cell receptor specific for a major histocompatibility complex class I molecule. J Exp Med. 1994 Aug 01; 180(2):687-92. Daniels BF, Karlhofer FM, Seaman WE, Yokoyama WM. PMID: 8046342.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    43. The Ly-49 and NKR-P1 gene families encoding lectin-like receptors on natural killer cells: the NK gene complex. Annu Rev Immunol. 1993; 11:613-35. Yokoyama WM, Seaman WE. PMID: 8476574.
      View in: PubMed   Mentions: 89     Fields:    Translation:AnimalsCells
    44. Molecular cloning of the NK1.1 antigen, a member of the NKR-P1 family of natural killer cell activation molecules. J Immunol. 1992 Sep 01; 149(5):1631-5. Ryan JC, Turck J, Niemi EC, Yokoyama WM, Seaman WE. PMID: 1506685.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    45. The OX-44 molecule couples to signaling pathways and is associated with CD2 on rat T lymphocytes and a natural killer cell line. J Exp Med. 1992 Feb 01; 175(2):527-36. Bell GM, Seaman WE, Niemi EC, Imboden JB. PMID: 1346273.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    46. NKR-P1, an activating molecule on rat natural killer cells, stimulates phosphoinositide turnover and a rise in intracellular calcium. J Immunol. 1991 Nov 01; 147(9):3244-50. Ryan JC, Niemi EC, Goldfien RD, Hiserodt JC, Seaman WE. PMID: 1919012.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    47. cDNA cloning of mouse NKR-P1 and genetic linkage with LY-49. Identification of a natural killer cell gene complex on mouse chromosome 6. J Immunol. 1991 Nov 01; 147(9):3229-36. Yokoyama WM, Ryan JC, Hunter JJ, Smith HR, Stark M, Seaman WE. PMID: 1680927.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    48. Divergent regulation of phospholipase C-alpha and phospholipase C-gamma transcripts during activation of a human T cell line. J Immunol. 1991 Jun 01; 146(11):3703-8. Goldfien RD, Seaman WE, Hempel WM, Imboden JB. PMID: 2033247.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    49. Characterization of signal-transducing molecules on natural killer cells. Biochem Soc Trans. 1991 Apr; 19(2):265-8. Imboden JB, Bell G, Seaman WE. PMID: 1679728.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    50. Molecular cloning of gp42, a cell-surface molecule that is selectively induced on rat natural killer cells by interleukin 2: glycolipid membrane anchoring and capacity for transmembrane signaling. J Exp Med. 1991 Jan 01; 173(1):251-60. Seaman WE, Niemi EC, Stark MR, Goldfien RD, Pollock AS, Imboden JB. PMID: 1845873.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    51. Identification and characterization of a cell-surface molecule that is selectively induced on rat lymphokine-activated killer cells. J Immunol. 1989 Nov 01; 143(9):3100-3. Imboden JB, Eriksson EC, McCutcheon M, Reynolds CW, Seaman WE. PMID: 2809220.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    52. Induction of immune tolerance during administration of monoclonal antibody to L3T4 does not depend on depletion of L3T4+ cells. J Immunol. 1988 Feb 01; 140(3):713-6. Carteron NL, Wofsy D, Seaman WE. PMID: 2448372.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    53. Receptor-specific mechanisms for the responses of human leukocytes to leukotrienes. Ann N Y Acad Sci. 1988; 524:345-55. Goetzl EJ, Sherman JW, Ratnoff WD, Harvey JP, Eriksson E, Seaman WE, Baud L, Koo CH. PMID: 2837968.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    54. Selective manipulation of the immune response in vivo by monoclonal antibodies. Annu Rev Med. 1988; 39:231-41. Seaman WE, Wofsy D. PMID: 3285774.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    55. Regulation of autoimmunity and donor cell engraftment by recipient Lyt-2+ cells during the graft-versus-host reaction. J Exp Med. 1987 Sep 01; 166(3):657-67. Harper SE, Roubinian JR, Seaman WE. PMID: 2957456.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    56. Randomized, double-blind, placebo-controlled study of the treatment of the painful shoulder. Arthritis Rheum. 1987 Sep; 30(9):1040-5. Petri M, Dobrow R, Neiman R, Whiting-O'Keefe Q, Seaman WE. PMID: 3311051.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansCTClinical Trials
    57. Depletion of natural killer cells in mice by monoclonal antibody to NK-1.1. Reduction in host defense against malignancy without loss of cellular or humoral immunity. J Immunol. 1987 Jun 15; 138(12):4539-44. Seaman WE, Sleisenger M, Eriksson E, Koo GC. PMID: 3584981.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    58. Inositol trisphosphate is generated by a rat natural killer cell tumor in response to target cells or to crosslinked monoclonal antibody OX-34: possible signaling role for the OX-34 determinant during activation by target cells. Proc Natl Acad Sci U S A. 1987 Jun; 84(12):4239-43. Seaman WE, Eriksson E, Dobrow R, Imboden JB. PMID: 3495804.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    59. Reversal of advanced murine lupus in NZB/NZW F1 mice by treatment with monoclonal antibody to L3T4. J Immunol. 1987 May 15; 138(10):3247-53. Wofsy D, Seaman WE. PMID: 3106478.
      View in: PubMed   Mentions: 33     Fields:    Translation:Animals
    60. In vivo effects of antilymphocyte antibodies on immunity and autoimmunity. Memórias do Instituto Oswaldo Cruz. 1987 Jan 1; 82(suppl 2):117-119. William E. Seaman, Nancy Gutstein, David Wofsy. .
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    61. Rejection of skin grafts and generation of cytotoxic T cells by mice depleted of L3T4+ cells. Transplantation. 1986 Dec; 42(6):636-42. Woodcock J, Wofsy D, Eriksson E, Scott JH, Seaman WE. PMID: 2947360.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    62. Induction of immune tolerance by administration of monoclonal antibody to L3T4. J Immunol. 1986 Aug 15; 137(4):1127-32. Gutstein NL, Seaman WE, Scott JH, Wofsy D. PMID: 3090139.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    63. Cocaine increases natural killer cell activity. J Clin Invest. 1986 Apr; 77(4):1387-90. Van Dyke C, Stesin A, Jones R, Chuntharapai A, Seaman W. PMID: 2937807.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    64. Analysis of the function of L3T4+ T cells by in vivo treatment with monoclonal antibody to L3T4. Immunol Res. 1986; 5(2):97-105. Wofsy D, Seaman WE. PMID: 3093610.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    65. Inhibition of humoral immunity in vivo by monoclonal antibody to L3T4: studies with soluble antigens in intact mice. J Immunol. 1985 Sep; 135(3):1698-701. Wofsy D, Mayes DC, Woodcock J, Seaman WE. PMID: 3160776.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    66. Human synovial dendritic cells. Direct observation of transition to fibroblasts. J Rheumatol. 1985 Aug; 12(4):660-4. Hendler PL, Lavoie PE, Werb Z, Chan J, Seaman WE. PMID: 3863955.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    67. Harvesting of leukocytes from intestinal lumen in murine giardiasis and preliminary characterization of these cells. Dig Dis Sci. 1985 Feb; 30(2):149-53. Heyworth MF, Owen RL, Seaman WE, Schaefer FW, Jones AL. PMID: 3881233.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    68. Successful treatment of autoimmunity in NZB/NZW F1 mice with monoclonal antibody to L3T4. J Exp Med. 1985 Feb 01; 161(2):378-91. Wofsy D, Seaman WE. PMID: 3919141.
      View in: PubMed   Mentions: 114     Fields:    Translation:AnimalsCells
    69. Treatment of murine lupus with monoclonal anti-T cell antibody. J Immunol. 1985 Feb; 134(2):852-7. Wofsy D, Ledbetter JA, Hendler PL, Seaman WE. PMID: 3871218.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    70. THE POTENTIAL ROLE OF ARACHIDONIC ACID METABOLISM IN NATURAL KILLER CELL ACTIVITY11Supported by Public Health Service grants Nos. CA34529 and AI5384 and by the Veterans Administration. Mechanisms of Cytotoxicity by NK Cells. 1985 Jan 1; 245-252. William E. Seaman, Janet Woodcock, Colin G. Brooks. .
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    71. Human and murine natural killer cell activity may require lipoxygenation of arachidonic acid. J Allergy Clin Immunol. 1984 Sep; 74(3 Pt 2):407-11. Seaman WE, Woodcock J. PMID: 6432881.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    72. The proliferating cells in autoimmune MRL/lpr mice lack L3T4, an antigen on "helper" T cells that is involved in the response to class II major histocompatibility antigens. J Immunol. 1984 Jun; 132(6):2686-9. Wofsy D, Hardy RR, Seaman WE. PMID: 6144707.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    73. Monocytosis in the BXSB model for systemic lupus erythematosus. J Exp Med. 1984 Feb 01; 159(2):629-34. Wofsy D, Kerger CE, Seaman WE. PMID: 6363600.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    74. Human natural killer cell activity is reversibly inhibited by antagonists of lipoxygenation. J Immunol. 1983 Dec; 131(6):2953-7. Seaman WE. PMID: 6417236.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    75. Natural killing activity in Sjögren's syndrome. An analysis of defective mechanisms. Arthritis Rheum. 1983 Aug; 26(8):954-60. Miyasaka N, Seaman W, Bakshi A, Sauvezie B, Strand V, Pope R, Talal N. PMID: 6882489.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    76. Treatment of autoimmune MRL/Ipr mice with monoclonal antibody to Thy-1.2: a single injection has sustained effects on lymphoproliferation and renal disease. J Immunol. 1983 Apr; 130(4):1713-8. Seaman WE, Wofsy D, Greenspan JS, Ledbetter JA. PMID: 6187819.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    77. Thymic influences on autoimmunity in MRL-lpr mice. Scand J Immunol. 1982 Jul; 16(1):51-8. Wofsy D, Ledbetter JA, Roubinian JR, Seaman WE, Talal N. PMID: 6981841.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    78. Suppression of natural killing in vitro by monocytes and polymorphonuclear leukocytes: requirement for reactive metabolites of oxygen. J Clin Invest. 1982 Apr; 69(4):876-88. Seaman WE, Gindhart TD, Blackman MA, Dalal B, Talal N, Werb Z. PMID: 7076851.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    79. The Lyt-2, Lyt-3 macromolecules: structural and functional studies. Immunol Rev. 1982; 68:197-218. Ledbetter JA, Seaman WE. PMID: 6757107.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    80. Suppression or enhancement of natural killing does not alter tolerance to bovine gamma globulin. J Clin Lab Immunol. 1981 Nov; 6(3):215-20. Loeb JM, Talal N, Abensohn-Lee M, Seaman WE. PMID: 6175754.
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    81. Surface antigens on mouse natural killer cells: use of monoclonal antibodies to inhibit or to enrich cytotoxic activity. J Immunol. 1981 Sep; 127(3):982-6. Seaman WE, Talal N, Herzenberg LA, Herzenberg LA, Ledbetter JA. PMID: 6790624.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    82. Natural killing by spleen cells from W/Wv and Sl/Sld anemic mice. Exp Hematol. 1981 Aug; 9(7):691-6. Seaman WE, Talal N. PMID: 7318972.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    83. Lyt-2 and lyt-3 antigens are on two different polypeptide subunits linked by disulfide bonds. Relationship of subunits to T cell cytolytic activity. J Exp Med. 1981 Jun 01; 153(6):1503-16. Ledbetter JA, Seaman WE, Tsu TT, Herzenberg LA. PMID: 6166718.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    84. Natural killing of tumor cells by human peripheral blood cells. Suppression of killing in vitro by tumor-promoting phorbol diesters. J Clin Invest. 1981 May; 67(5):1324-33. Seaman WE, Gindhart TD, Blackman MA, Dalal B, Talal N, Werb Z. PMID: 6939690.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    85. Effect of 89Sr on immunity and autoimmunity in NZB/NZW F1 mice. J Immunol. 1980 Feb; 124(2):812-8. Seaman WE, Blackman MA, Greenspan JS, Talal N. PMID: 6985937.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    86. THE EFFECT OF 17ß-ESTRADIOL ON NATURAL KILLING IN THE MOUSE. Natural Cell-mediated Immunity Against Tumors. 1980 Jan 1; 765-777. William E. Seaman, Norman Talal. .
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    87. Natural killing in estrogen-treated mice responds poorly to poly I.C despite normal stimulation of circulating interferon. J Immunol. 1979 Dec; 123(6):2903-5. Seaman WE, Merigan TC, Talal N. PMID: 227961.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    88. Effect of estrogen on natural killer cells. Arthritis Rheum. 1979 Nov; 22(11):1234-40. Seaman WE, Gindhart TD. PMID: 389248.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    89. Natural killer cells, bone, and the bone marrow: studies in estrogen-treated mice and in congenitally osteopetrotic (mi/mi) mice. J Immunol. 1979 Jun; 122(6):2541-7. Seaman WE, Gindhart TD, Greenspan JS, Blackman MA, Talal N. PMID: 376736.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    90. beta-Estradiol reduces natural killer cells in mice. J Immunol. 1978 Dec; 121(6):2193-8. Seaman WE, Blackman MA, Gindhart TD, Roubinian JR, Loeb JM, Talal N. PMID: 722074.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    91. Hepatic injury due to acetaminophen or salicylates. West J Med. 1978 Aug; 129(2):136-7. Seaman WE. PMID: 18748273.
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    92. Letter: Effect of salicylates on creatinine clearance. Br Med J. 1976 Aug 14; 2(6032):421-2. Plotz P, Kimberly R, Gill JR, Seaman W. PMID: 947455.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    93. Effect of aspirin on liver tests in patients with RA or SLE and in normal volunteers. Arthritis Rheum. 1976 Mar-Apr; 19(2):155-60. Seaman WE, Plotz PH. PMID: 1259798.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    94. Systemic lupus erythematosus. Contrasts and comparisons. Ann Intern Med. 1975 Mar; 82(3):391-404. Decker JL, Steinberg AD, Gershwin ME, Seaman WE, Klippel JH, Plotz PH, Paget SA. PMID: 1115477.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    95. Avascular necrosis of the talus, scaphoid, and metatarsal head in systemic lupus erythematosus. Clin Orthop Relat Res. 1974 Jun; (101):127-8. Aptekar RG, Klippel JH, Becker KE, Carson DA, Seaman WE, Decker JL. PMID: 4837924.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    96. Proceedings: Aspirin-induced hepatotoxicity in patients with RA or systemic lupus erythematosus (SLE). Arthritis Rheum. 1974 May-Jun; 17(3):325. Seaman WE, Plotz PH, Ishak KG. PMID: 4825655.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    97. Letter: Aspirin and hepatotoxicity: addendum. Ann Intern Med. 1974 Feb; 80(2):279. Seaman WE, Ishak KG, Plotz PH. PMID: 4811807.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    98. Aspirin-induced hepatotoxicity in patients with systemic lupus erythematosus. Ann Intern Med. 1974 Jan; 80(1):1-8. Seaman WE, Ishak KG, Plotz PH. PMID: 4810348.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
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