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Eric Lam, PhD

TitleAssistant Professor
InstitutionUniversity of California San Francisco
DepartmentBiochemistry and Biophysics
Address600 16th St
San Francisco CA 94158
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Zhang B, Fu D, Xu Q, Cong X, Wu C, Zhong X, Ma Y, Lv Z, Chen F, Han L, Qian M, Chin YE, Lam E, Chiao P, Sun Y. The senescence-associated secretory phenotype is potentiated by feedforward regulatory mechanisms involving Zscan4 and TAK1. Nat Commun. 2018 Apr 30; 9(1):1723. PMID: 29712904.
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    2. Nestal de Moraes G, Ji Z, Fan LY, Yao S, Zona S, Sharrocks AD, Lam E. SUMOylation modulates FOXK2-mediated paclitaxel sensitivity in breast cancer cells. Oncogenesis. 2018 Mar 13; 7(3):29. PMID: 29540677.
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    3. Asaduzzaman M, Constantinou S, Min H, Gallon J, Lin ML, Singh P, Raguz S, Ali S, Shousha S, Charles Coombes R, Lam E, Hu Y, Yagüe E. Correction to: Tumour suppressor EP300, a modulator of paclitaxel resistance and stemness, is downregulated in metaplastic breast cancer. Breast Cancer Res Treat. 2018 Jan; 167(2):605-606. PMID: 29305809.
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    4. Roig B, Rodríguez-Balada M, Samino S, Lam E, Guaita-Esteruelas S, Gomes AR, Correig X, Borràs J, Yanes O, Gumà J. Metabolomics reveals novel blood plasma biomarkers associated to the BRCA1-mutated phenotype of human breast cancer. Sci Rep. 2017 Dec 19; 7(1):17831. PMID: 29259228.
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    5. Yao S, Fan LY, Lam E. The FOXO3-FOXM1 axis: A key cancer drug target and a modulator of cancer drug resistance. Semin Cancer Biol. 2017 Nov 24. PMID: 29180117.
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    6. Li SS, Xu LZ, Zhou W, Yao S, Wang CL, Xia JL, Wang HF, Kamran M, Xue XY, Dong L, Wang J, Ding XD, Bella L, Bugeon L, Xu J, Zheng FM, Dallman MJ, Lam E, Liu Q. p62/SQSTM1 interacts with vimentin to enhance breast cancer metastasis. Carcinogenesis. 2017 Oct 26; 38(11):1092-1103. PMID: 28968743.
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    7. Alasiri G, Fan LY, Zona S, Goldsbrough IG, Ke HL, Auner HW, Lam E. ER stress and cancer: The FOXO forkhead transcription factor link. Mol Cell Endocrinol. 2018 Feb 15; 462(Pt B):67-81. PMID: 28572047.
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    8. Lau CE, Tredwell GD, Ellis JK, Lam E, Keun HC. Metabolomic characterisation of the effects of oncogenic PIK3CA transformation in a breast epithelial cell line. Sci Rep. 2017 Apr 10; 7:46079. PMID: 28393905.
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    9. Shahidi N, Ou G, Lam E, Enns R, Telford J. When trainees reach competency in performing endoscopic ultrasound: a systematic review. Endosc Int Open. 2017 Apr; 5(4):E239-E243. PMID: 28367496.
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    10. Saavedra-García P, Fan LY, Lam E. Multifaceted link between metabolism and cancer. Mol Cell Endocrinol. 2018 Feb 15; 462(Pt B):65-66. PMID: 28351646.
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    11. Asaduzzaman M, Constantinou S, Min H, Gallon J, Lin ML, Singh P, Raguz S, Ali S, Shousha S, Coombes RC, Lam E, Hu Y, Yagüe E. Tumour suppressor EP300, a modulator of paclitaxel resistance and stemness, is downregulated in metaplastic breast cancer. Breast Cancer Res Treat. 2017 Jun; 163(3):461-474. PMID: 28341962.
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    12. Fan LY, Saavedra-García P, Lam E. Dataset of the human homologues and orthologues of lipid-metabolic genes identified as DAF-16 targets their roles in lipid and energy metabolism. Data Brief. 2017 Apr; 11:606-610. PMID: 28349111.
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    13. Sundriyal S, Moniot S, Mahmud Z, Yao S, Di Fruscia P, Reynolds CR, Dexter DT, Sternberg MJ, Lam E, Steegborn C, Fuchter MJ. Thienopyrimidinone Based Sirtuin-2 (SIRT2)-Selective Inhibitors Bind in the Ligand Induced Selectivity Pocket. J Med Chem. 2017 Mar 09; 60(5):1928-1945. PMID: 28135086.
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    14. Peng F, Li TT, Wang KL, Xiao GQ, Wang JH, Zhao HD, Kang ZJ, Fan WJ, Zhu LL, Li M, Cui B, Zheng FM, Wang HJ, Lam E, Wang B, Xu J, Liu Q. H19/let-7/LIN28 reciprocal negative regulatory circuit promotes breast cancer stem cell maintenance. Cell Death Dis. 2017 01 19; 8(1):e2569. PMID: 28102845.
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    15. Saavedra-García P, Nichols K, Mahmud Z, Fan LY, Lam E. Unravelling the role of fatty acid metabolism in cancer through the FOXO3-FOXM1 axis. Mol Cell Endocrinol. 2018 Feb 15; 462(Pt B):82-92. PMID: 28087388.
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    16. Mitchell RA, Stanger D, Shuster C, Telford J, Lam E, Enns R. Repeat Endoscopic Ultrasound-Guided Fine-Needle Aspiration in Patients with Suspected Pancreatic Cancer: Diagnostic Yield and Associated Change in Access to Appropriate Care. Can J Gastroenterol Hepatol. 2016; 2016:7678403. PMID: 27648440.
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    17. Lemos LG, Nestal de Moraes G, Delbue D, Vasconcelos Fda C, Bernardo PS, Lam E, Buarque CD, Costa PR, Maia RC. 11a-N-Tosyl-5-deoxi-pterocarpan, LQB-223, a novel compound with potent antineoplastic activity toward breast cancer cells with different phenotypes. J Cancer Res Clin Oncol. 2016 Oct; 142(10):2119-30. PMID: 27520309.
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    18. Yan M, Wang C, He B, Yang M, Tong M, Long Z, Liu B, Peng F, Xu L, Zhang Y, Liang D, Lei H, Subrata S, Kelley KW, Lam E, Jin B, Liu Q. Aurora-A Kinase: A Potent Oncogene and Target for Cancer Therapy. Med Res Rev. 2016 11; 36(6):1036-1079. PMID: 27406026.
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    19. Anghelina D, Lam E, Falck-Pedersen E. Diminished Innate Antiviral Response to Adenovirus Vectors in cGAS/STING-Deficient Mice Minimally Impacts Adaptive Immunity. J Virol. 2016 07 01; 90(13):5915-27. PMID: 27076643; PMCID: PMC4907218 [Available on 12/10/16].
    20. Yong JS, Intriago-Baldeón DP, Lam E. FOXD3 controls pluripotency through modulating enhancer activity. Stem Cell Investig. 2016; 3:17. PMID: 27488581.
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    21. Guaita-Esteruelas S, Bosquet A, Saavedra P, Gumà J, Girona J, Lam E, Amillano K, Borràs J, Masana L. Exogenous FABP4 increases breast cancer cell proliferation and activates the expression of fatty acid transport proteins. Mol Carcinog. 2017 01; 56(1):208-217. PMID: 27061264.
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    22. Zheng F, Yue C, Li G, He B, Cheng W, Wang X, Yan M, Long Z, Qiu W, Yuan Z, Xu J, Liu B, Shi Q, Lam E, Hung MC, Liu Q. Nuclear AURKA acquires kinase-independent transactivating function to enhance breast cancer stem cell phenotype. Nat Commun. 2016 Jan 19; 7:10180. PMID: 26782714.
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    23. Khongkow P, Middleton AW, Wong JP, Kandola NK, Kongsema M, de Moraes GN, Gomes AR, Lam E. Erratum to: In Vitro Methods for Studying the Mechanisms of Resistance to DNA-Damaging Therapeutic Drugs. Methods Mol Biol. 2016; 1395:E1. PMID: 27488409.
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    24. Gomes AR, Yong JS, Kiew KC, Aydin E, Khongkow M, Laohasinnarong S, Lam E. Sirtuin1 (SIRT1) in the Acetylation of Downstream Target Proteins. Methods Mol Biol. 2016; 1436:169-88. PMID: 27246215.
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    25. Nestal de Moraes G, Bella L, Zona S, Burton MJ, Lam E. Insights into a Critical Role of the FOXO3a-FOXM1 Axis in DNA Damage Response and Genotoxic Drug Resistance. Curr Drug Targets. 2016; 17(2):164-77. PMID: 25418858.
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    26. Khongkow P, Middleton AW, Middleton AK, Wong JP, Kandola NK, Kongsema M, de Moraes GN, Gomes AR, Lam E. In Vitro Methods for Studying the Mechanisms of Resistance to DNA-Damaging Therapeutic Drugs. Methods Mol Biol. 2016; 1395:39-53. PMID: 26910067.
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    27. Lucas ES, Dyer NP, Murakami K, Lee YH, Chan YW, Grimaldi G, Muter J, Brighton PJ, Moore JD, Patel G, Chan JK, Takeda S, Lam E, Quenby S, Ott S, Brosens JJ. Loss of Endometrial Plasticity in Recurrent Pregnancy Loss. Stem Cells. 2016 Feb; 34(2):346-56. PMID: 26418742.
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    28. Silva LS, Goncalves LG, Silva F, Domingues G, Maximo V, Ferreira J, Lam E, Dias S, Felix A, Serpa J. STAT3:FOXM1 and MCT1 drive uterine cervix carcinoma fitness to a lactate-rich microenvironment. Tumour Biol. 2016 Apr; 37(4):5385-95. PMID: 26563366.
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    29. Nestal de Moraes G, Delbue D, Silva KL, Robaina MC, Khongkow P, Gomes AR, Zona S, Crocamo S, Mencalha AL, Magalhães LM, Lam E, Maia RC. FOXM1 targets XIAP and Survivin to modulate breast cancer survival and chemoresistance. Cell Signal. 2015 Dec; 27(12):2496-505. PMID: 26404623.
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    30. Consolaro F, Ghaem-Maghami S, Bortolozzi R, Zona S, Khongkow M, Basso G, Viola G, Lam E. FOXO3a and Posttranslational Modifications Mediate Glucocorticoid Sensitivity in B-ALL. Mol Cancer Res. 2015 Dec; 13(12):1578-90. PMID: 26376801.
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    31. Magnani L, Patten DK, Nguyen VT, Hong SP, Steel JH, Patel N, Lombardo Y, Faronato M, Gomes AR, Woodley L, Page K, Guttery D, Primrose L, Fernandez Garcia D, Shaw J, Viola P, Green A, Nolan C, Ellis IO, Rakha EA, Shousha S, Lam E, Gyorffy B, Lupien M, Coombes RC. The pioneer factor PBX1 is a novel driver of metastatic progression in ERa-positive breast cancer. Oncotarget. 2015 Sep 08; 6(26):21878-91. PMID: 26215677; PMCID: PMC4673133.
    32. Consolaro F, Basso G, Ghaem-Magami S, Lam E, Viola G. FOXM1 is overexpressed in B-acute lymphoblastic leukemia (B-ALL) and its inhibition sensitizes B-ALL cells to chemotherapeutic drugs. Int J Oncol. 2015 Oct; 47(4):1230-40. PMID: 26316295; PMCID: PMC4583527.
    33. Lam E, Choi SH, Pareek TK, Kim BG, Letterio JJ. Cyclin-dependent kinase 5 represses Foxp3 gene expression and Treg development through specific phosphorylation of Stat3 at Serine 727. Mol Immunol. 2015 Oct; 67(2 Pt B):317-24. PMID: 26198700; PMCID: PMC4734131 [Available on 10/01/16].
    34. Muter J, Lucas ES, Chan YW, Brighton PJ, Moore JD, Lacey L, Quenby S, Lam E, Brosens JJ. The clock protein period 2 synchronizes mitotic expansion and decidual transformation of human endometrial stromal cells. FASEB J. 2015 Apr; 29(4):1603-14. PMID: 25573754; PMCID: PMC4396614.
    35. Lam E, Pareek TK, Letterio JJ. Cdk5 controls IL-2 gene expression via repression of the mSin3a-HDAC complex. Cell Cycle. 2015; 14(8):1327-36. PMID: 25785643; PMCID: PMC4614394.
    36. Zhao F, Siu MK, Jiang L, Tam KF, Ngan HY, Le XF, Wong OG, Wong ES, Gomes AR, Bella L, Khongkow P, Lam E, Cheung AN. Overexpression of forkhead box protein M1 (FOXM1) in ovarian cancer correlates with poor patient survival and contributes to paclitaxel resistance. PLoS One. 2014; 9(11):e113478. PMID: 25411964.
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    37. Di Fruscia P, Zacharioudakis E, Liu C, Moniot S, Laohasinnarong S, Khongkow M, Harrison IF, Koltsida K, Reynolds CR, Schmidtkunz K, Jung M, Chapman KL, Steegborn C, Dexter DT, Sternberg MJ, Lam E, Fuchter MJ. The discovery of a highly selective 5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one SIRT2 inhibitor that is neuroprotective in an in vitro Parkinson's disease model. ChemMedChem. 2015 Jan; 10(1):69-82. PMID: 25395356.
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    38. Lam E, Gomes AR. Forkhead box transcription factors in cancer initiation, progression and chemotherapeutic drug response. Front Oncol. 2014; 4:305. PMID: 25401090; PMCID: PMC4212617.
    39. Lam E, Falck-Pedersen E. Unabated adenovirus replication following activation of the cGAS/STING-dependent antiviral response in human cells. J Virol. 2014 Dec; 88(24):14426-39. PMID: 25297994; PMCID: PMC4249147.
    40. Zona S, Bella L, Burton MJ, Nestal de Moraes G, Lam E. FOXM1: an emerging master regulator of DNA damage response and genotoxic agent resistance. Biochim Biophys Acta. 2014 Nov; 1839(11):1316-22. PMID: 25287128.
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    41. Nestal de Moraes G, Castro CP, Salustiano EJ, Dumas ML, Costas F, Lam E, Costa PR, Maia RC. The pterocarpanquinone LQB-118 induces apoptosis in acute myeloid leukemia cells of distinct molecular subtypes and targets FoxO3a and FoxM1 transcription factors. Int J Oncol. 2014 Nov; 45(5):1949-58. PMID: 25174716.
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    42. Bella L, Zona S, Nestal de Moraes G, Lam E. FOXM1: A key oncofoetal transcription factor in health and disease. Semin Cancer Biol. 2014 Dec; 29:32-9. PMID: 25068996.
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    43. Mowla SN, Lam E, Jat PS. Cellular senescence and aging: the role of B-MYB. Aging Cell. 2014 Oct; 13(5):773-9. PMID: 24981831; PMCID: PMC4331756.
    44. Zheng FM, Long ZJ, Hou ZJ, Luo Y, Xu LZ, Xia JL, Lai XJ, Liu JW, Wang X, Kamran M, Yan M, Shao SJ, Lam E, Wang SW, Lu G, Liu Q. A novel small molecule aurora kinase inhibitor attenuates breast tumor-initiating cells and overcomes drug resistance. Mol Cancer Ther. 2014 Aug; 13(8):1991-2003. PMID: 24899685.
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    45. Wang J, Taylor A, Showeil R, Trivedi P, Horimoto Y, Bagwan I, Ewington L, Lam E, El-Bahrawy MA. Expression profiling and significance of VEGF-A, VEGFR2, VEGFR3 and related proteins in endometrial carcinoma. Cytokine. 2014 Aug; 68(2):94-100. PMID: 24845798.
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    46. Yan M, Zhang Y, He B, Xiang J, Wang ZF, Zheng FM, Xu J, Chen MY, Zhu YL, Wen HJ, Wan XB, Yue CF, Yang N, Zhang W, Zhang JL, Wang J, Wang Y, Li LH, Zeng YX, Lam E, Hung MC, Liu Q. IKKa restoration via EZH2 suppression induces nasopharyngeal carcinoma differentiation. Nat Commun. 2014 Apr 17; 5:3661. PMID: 24739462.
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    47. Ou G, Kim E, Lakzadeh P, Tong J, Enns R, Ramji A, Whittaker S, Ko HH, Bressler B, Halparin L, Lam E, Amar J, Telford J. A randomized controlled trial assessing the effect of prescribed patient position changes during colonoscope withdrawal on adenoma detection. Gastrointest Endosc. 2014 Aug; 80(2):277-83. PMID: 24629419.
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    48. Luo C, Lam E. Quantitatively profiling genome-wide patterns of histone modifications in Arabidopsis thaliana using ChIP-seq. Methods Mol Biol. 2014; 1112:177-93. PMID: 24478015.
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    49. Lam E, Stein S, Falck-Pedersen E. Adenovirus detection by the cGAS/STING/TBK1 DNA sensing cascade. J Virol. 2014 Jan; 88(2):974-81. PMID: 24198409; PMCID: PMC3911663.
    50. Brahmania M, Ou G, Bressler B, Ko HK, Lam E, Telford J, Enns R. 2 L versus 4 L of PEG3350 + electrolytes for outpatient colonic preparation: a randomized, controlled trial. Gastrointest Endosc. 2014 Mar; 79(3):408-416.e4. PMID: 24206747.
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    51. Lam E, Brosens JJ, Gomes AR, Koo CY. Forkhead box proteins: tuning forks for transcriptional harmony. Nat Rev Cancer. 2013 Jul; 13(7):482-95. PMID: 23792361.
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    52. Gomes AR, Zhao F, Lam E. Role and regulation of the forkhead transcription factors FOXO3a and FOXM1 in carcinogenesis and drug resistance. Chin J Cancer. 2013 Jul; 32(7):365-70. PMID: 23706767; PMCID: PMC3845605.
    53. Brosens JJ, Lam E. Progesterone and FOXO1 signaling: harnessing cellular senescence for the treatment of ovarian cancer. Cell Cycle. 2013 Jun 01; 12(11):1660-1. PMID: 23708447; PMCID: PMC3713121.
    54. Zhao F, Lam E. Role of the forkhead transcription factor FOXO-FOXM1 axis in cancer and drug resistance. Front Med. 2012 Dec; 6(4):376-80. PMID: 23124885.
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    55. Stein SC, Lam E, Falck-Pedersen E. Cell-specific regulation of nucleic acid sensor cascades: a controlling interest in the antiviral response. J Virol. 2012 Dec; 86(24):13303-12. PMID: 23015711; PMCID: PMC3503059.
    56. McGonnell IM, Grigoriadis AE, Lam E, Price JS, Sunters A. A specific role for phosphoinositide 3-kinase and AKT in osteoblasts? Front Endocrinol (Lausanne). 2012; 3:88. PMID: 22833734; PMCID: PMC3400941.
    57. de Olano N, Koo CY, Monteiro LJ, Pinto PH, Gomes AR, Aligue R, Lam E. The p38 MAPK-MK2 axis regulates E2F1 and FOXM1 expression after epirubicin treatment. Mol Cancer Res. 2012 Sep; 10(9):1189-202. PMID: 22802261; PMCID: PMC3447739.
    58. Barros P, Lam E, Jordan P, Matos P. Rac1 signalling modulates a STAT5/BCL-6 transcriptional switch on cell-cycle-associated target gene promoters. Nucleic Acids Res. 2012 Sep; 40(16):7776-87. PMID: 22723377; PMCID: PMC3439931.
    59. Lam E, Zhang Y. Regulating the reapers: activating metacaspases for programmed cell death. Trends Plant Sci. 2012 Aug; 17(8):487-94. PMID: 22658651.
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    60. Ewington L, Taylor A, Sriraksa R, Horimoto Y, Lam E, El-Bahrawy MA. The expression of interleukin-8 and interleukin-8 receptors in endometrial carcinoma. Cytokine. 2012 Aug; 59(2):417-22. PMID: 22626766.
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    61. Down CF, Millour J, Lam E, Watson RJ. Binding of FoxM1 to G2/M gene promoters is dependent upon B-Myb. Biochim Biophys Acta. 2012 Aug; 1819(8):855-62. PMID: 22513242.
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    62. Choi O, Heathcote DA, Ho KK, Müller PJ, Ghani H, Lam E, Ashton-Rickardt PG, Rutschmann S. A deficiency in nucleoside salvage impairs murine lymphocyte development, homeostasis, and survival. J Immunol. 2012 Apr 15; 188(8):3920-7. PMID: 22407915; PMCID: PMC3378644.
    63. Huang C, Han X, Li X, Lam E, Peng W, Lou N, Torres A, Yang M, Garre JM, Tian GF, Bennett MV, Nedergaard M, Takano T. Critical role of connexin 43 in secondary expansion of traumatic spinal cord injury. J Neurosci. 2012 Mar 07; 32(10):3333-8. PMID: 22399755; PMCID: PMC3569730.
    64. Di Fruscia P, Ho KK, Laohasinnarong S, Khongkow M, Kroll SH, Islam SA, Sternberg MJ, Schmidtkunz K, Jung M, Lam E, Fuchter MJ. The Discovery of Novel 10,11-Dihydro-5H-dibenz[b,f]azepine SIRT2 Inhibitors. Medchemcomm. 2012 Mar 01; (3). PMID: 24340169.
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    65. Zhao H, Appenroth K, Landesman L, Salmeán AA, Lam E. Duckweed rising at Chengdu: summary of the 1st International Conference on Duckweed Application and Research. Plant Mol Biol. 2012 Apr; 78(6):627-32. PMID: 22318677.
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    66. McKie AB, Vaughan S, Zanini E, Okon IS, Louis L, de Sousa C, Greene MI, Wang Q, Agarwal R, Shaposhnikov D, Wong JL, Gungor H, Janczar S, El-Bahrawy M, Lam E, Chayen NE, Gabra H. The OPCML tumor suppressor functions as a cell surface repressor-adaptor, negatively regulating receptor tyrosine kinases in epithelial ovarian cancer. Cancer Discov. 2012 Feb; 2(2):156-71. PMID: 22585860; PMCID: PMC3378039.
    67. Yusuf D, Butland SL, Swanson MI, Bolotin E, Ticoll A, Cheung WA, Zhang XY, Dickman CT, Fulton DL, Lim JS, Schnabl JM, Ramos OH, Vasseur-Cognet M, de Leeuw CN, Simpson EM, Ryffel GU, Lam E, Kist R, Wilson MS, Marco-Ferreres R, Brosens JJ, Beccari LL, Bovolenta P, Benayoun BA, Monteiro LJ, Schwenen HD, Grontved L, Wederell E, Mandrup S, Veitia RA, Chakravarthy H, Hoodless PA, Mancarelli MM, Torbett BE, Banham AH, Reddy SP, Cullum RL, Liedtke M, Tschan MP, Vaz M, Rizzino A, Zannini M, Frietze S, Farnham PJ, Eijkelenboom A, Brown PJ, Laperrière D, Leprince D, de Cristofaro T, Prince KL, Putker M, del Peso L, Camenisch G, Wenger RH, Mikula M, Rozendaal M, Mader S, Ostrowski J, Rhodes SJ, Van Rechem C, Boulay G, Olechnowicz SW, Breslin MB, Lan MS, Nanan KK, Wegner M, Hou J, Mullen RD, Colvin SC, Noy PJ, Webb CF, Witek ME, Ferrell S, Daniel JM, Park J, Waldman SA, Peet DJ, Taggart M, Jayaraman PS, Karrich JJ, Blom B, Vesuna F, O'Geen H, Sun Y, Gronostajski RM, Woodcroft MW, Hough MR, Chen E, Europe-Finner GN, Karolczak-Bayatti M, Bailey J, Hankinson O, Raman V, LeBrun DP, Biswal S, Harvey CJ, DeBruyne JP, Hogenesch JB, Hevner RF, Héligon C, Luo XM, Blank MC, Millen KJ, Sharlin DS, Forrest D, Dahlman-Wright K, Zhao C, Mishima Y, Sinha S, Chakrabarti R, Portales-Casamar E, Sladek FM, Bradley PH, Wasserman WW. The transcription factor encyclopedia. Genome Biol. 2012; 13(3):R24. PMID: 22458515; PMCID: PMC3439975.
    68. Ho KK, McGuire VA, Koo CY, Muir KW, de Olano N, Maifoshie E, Kelly DJ, McGovern UB, Monteiro LJ, Gomes AR, Nebreda AR, Campbell DG, Arthur JS, Lam E. Phosphorylation of FOXO3a on Ser-7 by p38 promotes its nuclear localization in response to doxorubicin. J Biol Chem. 2012 Jan 06; 287(2):1545-55. PMID: 22128155; PMCID: PMC3256863.
    69. Al-Sabbagh M, Lam E, Brosens JJ. Mechanisms of endometrial progesterone resistance. Mol Cell Endocrinol. 2012 Jul 25; 358(2):208-15. PMID: 22085558.
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    70. Koo CY, Muir KW, Lam E. FOXM1: From cancer initiation to progression and treatment. Biochim Biophys Acta. 2012 Jan; 1819(1):28-37. PMID: 21978825.
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    71. Jiang L, Siu MK, Wong OG, Tam KF, Lu X, Lam E, Ngan HY, Le XF, Wong ES, Monteiro LJ, Chan HY, Cheung AN. iASPP and chemoresistance in ovarian cancers: effects on paclitaxel-mediated mitotic catastrophe. Clin Cancer Res. 2011 Nov 01; 17(21):6924-33. PMID: 21926165.
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    72. Christian M, Lam E, Wilson MS, Brosens JJ. FOXO transcription factors and their role in disorders of the female reproductive tract. Curr Drug Targets. 2011 Aug; 12(9):1291-302. PMID: 21443468.
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    73. Wilson MS, Brosens JJ, Schwenen HD, Lam E. FOXO and FOXM1 in cancer: the FOXO-FOXM1 axis shapes the outcome of cancer chemotherapy. Curr Drug Targets. 2011 Aug; 12(9):1256-66. PMID: 21443467.
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    74. Horimoto Y, Hartman J, Millour J, Pollock S, Olmos Y, Ho KK, Coombes RC, Poutanen M, Mäkelä SI, El-Bahrawy M, Speirs V, Lam E. ERß1 represses FOXM1 expression through targeting ERa to control cell proliferation in breast cancer. Am J Pathol. 2011 Sep; 179(3):1148-56. PMID: 21763263; PMCID: PMC3157253.
    75. Kenny LM, Lam E. Review: lapatinib in metastatic colorectal cancer-another strategy for disease control? Clin Adv Hematol Oncol. 2011 Jun; 9(6):500-1. PMID: 21841752.
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    76. Watanabe N, Lam E. Arabidopsis metacaspase 2d is a positive mediator of cell death induced during biotic and abiotic stresses. Plant J. 2011 Jun; 66(6):969-82. PMID: 21395887.
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    77. Millour J, de Olano N, Horimoto Y, Monteiro LJ, Langer JK, Aligue R, Hajji N, Lam E. ATM and p53 regulate FOXM1 expression via E2F in breast cancer epirubicin treatment and resistance. Mol Cancer Ther. 2011 Jun; 10(6):1046-58. PMID: 21518729; PMCID: PMC4845881.
    78. van Loosdregt J, Brunen D, Fleskens V, Pals CE, Lam E, Coffer PJ. Rapid temporal control of Foxp3 protein degradation by sirtuin-1. PLoS One. 2011 Apr 20; 6(4):e19047. PMID: 21533107; PMCID: PMC3080399.
    79. Lam E, Shah K, Brosens JJ. The diversity of sex steroid action: the role of micro-RNAs and FOXO transcription factors in cycling endometrium and cancer. J Endocrinol. 2012 Jan; 212(1):13-25. PMID: 21382987.
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    80. Kumar S, Alibhai D, Margineanu A, Laine R, Kennedy G, McGinty J, Warren S, Kelly D, Alexandrov Y, Munro I, Talbot C, Stuckey DW, Kimberly C, Viellerobe B, Lacombe F, Lam E, Taylor H, Dallman MJ, Stamp G, Murray EJ, Stuhmeier F, Sardini A, Katan M, Elson DS, Neil MA, Dunsby C, French PM. FLIM FRET technology for drug discovery: automated multiwell-plate high-content analysis, multiplexed readouts and application in situ. Chemphyschem. 2011 Feb 25; 12(3):609-26. PMID: 21337485; PMCID: PMC3084521.
    81. Watanabe N, Lam E. Calcium-dependent activation and autolysis of Arabidopsis metacaspase 2d. J Biol Chem. 2011 Mar 25; 286(12):10027-40. PMID: 21209078; PMCID: PMC3060454.
    82. Amini A, Luo C, Lam E. Chromatin beacons: global sampling of chromatin physical properties using chromatin charting lines. Methods Mol Biol. 2011; 701:301-14. PMID: 21181538.
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    83. Olmos Y, Brosens JJ, Lam E. Interplay between SIRT proteins and tumour suppressor transcription factors in chemotherapeutic resistance of cancer. Drug Resist Updat. 2011 Feb; 14(1):35-44. PMID: 21195657.
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    84. Jiang L, Siu MK, Wong OG, Tam KF, Lam E, Ngan HY, Le XF, Wong ES, Chan HY, Cheung AN. Overexpression of proto-oncogene FBI-1 activates membrane type 1-matrix metalloproteinase in association with adverse outcome in ovarian cancers. Mol Cancer. 2010 Dec 21; 9:318. PMID: 21176152; PMCID: PMC3022670.
    85. Al-Sabbagh M, Fusi L, Higham J, Lee Y, Lei K, Hanyaloglu AC, Lam E, Christian M, Brosens JJ. NADPH oxidase-derived reactive oxygen species mediate decidualization of human endometrial stromal cells in response to cyclic AMP signaling. Endocrinology. 2011 Feb; 152(2):730-40. PMID: 21159852; PMCID: PMC3037160.
    86. Lee MM, Jacques A, Lam E, Kwok R, Lakzadeh P, Sandhar A, Segal B, Svarta S, Law J, Enns R. Factors associated with incomplete small bowel capsule endoscopy studies. World J Gastroenterol. 2010 Nov 14; 16(42):5329-33. PMID: 21072896; PMCID: PMC2980682.
    87. Myatt SS, Brosens JJ, Lam E. Sense and sensitivity: FOXO and ROS in cancer development and treatment. Antioxid Redox Signal. 2011 Feb 15; 14(4):675-87. PMID: 20649462.
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    88. Pareek TK, Lam E, Zheng X, Askew D, Kulkarni AB, Chance MR, Huang AY, Cooke KR, Letterio JJ. Cyclin-dependent kinase 5 activity is required for T cell activation and induction of experimental autoimmune encephalomyelitis. J Exp Med. 2010 Oct 25; 207(11):2507-19. PMID: 20937706; PMCID: PMC2964575.
    89. Serpa J, Caiado F, Carvalho T, Torre C, Gonçalves LG, Casalou C, Lamosa P, Rodrigues M, Zhu Z, Lam E, Dias S. Butyrate-rich colonic microenvironment is a relevant selection factor for metabolically adapted tumor cells. J Biol Chem. 2010 Dec 10; 285(50):39211-23. PMID: 20926374; PMCID: PMC2998102.
    90. Mena AL, Lam E, Chatterjee S. Sustained spindle-assembly checkpoint response requires de novo transcription and translation of cyclin B1. PLoS One. 2010 Sep 28; 5(9). PMID: 20927403; PMCID: PMC2946930.
    91. Chen J, Gomes AR, Monteiro LJ, Wong SY, Wu LH, Ng TT, Karadedou CT, Millour J, Ip YC, Cheung YN, Sunters A, Chan KY, Lam E, Khoo US. Constitutively nuclear FOXO3a localization predicts poor survival and promotes Akt phosphorylation in breast cancer. PLoS One. 2010 Aug 20; 5(8):e12293. PMID: 20808831; PMCID: PMC2924889.
    92. Ferrari-Amorotti G, Mariani SA, Novi C, Cattelani S, Pecorari L, Corradini F, Soliera AR, Manzotti G, Fragliasso V, Zhang Y, Martinez RV, Lam E, Guerzoni C, Calabretta B. The biological effects of C/EBPalpha in K562 cells depend on the potency of the N-terminal regulatory region, not on specificity of the DNA binding domain. J Biol Chem. 2010 Oct 01; 285(40):30837-50. PMID: 20659895; PMCID: PMC2945577.
    93. Karim Z, Walker B, Lam E. Lymphoepithelial cysts of the pancreas: the use of endoscopic ultrasound-guided fine-needle aspiration in diagnosis. Can J Gastroenterol. 2010 Jun; 24(6):348-50. PMID: 20559575; PMCID: PMC2898487.
    94. Packard CE, Murarka A, Lam E, Schmidt MA, Bulovic V. Contact-printed microelectromechanical systems. Adv Mater. 2010 Apr 22; 22(16):1840-4. PMID: 20512958.
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    95. Peck B, Chen CY, Ho KK, Di Fruscia P, Myatt SS, Coombes RC, Fuchter MJ, Hsiao CD, Lam E. SIRT inhibitors induce cell death and p53 acetylation through targeting both SIRT1 and SIRT2. Mol Cancer Ther. 2010 Apr; 9(4):844-55. PMID: 20371709.
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    96. Brahmania M, Lam E, Telford J, Enns R. Endoscopic mucosal resection: early experience in British Columbia. Can J Gastroenterol. 2010 Apr; 24(4):239-44. PMID: 20431812; PMCID: PMC2864619.
    97. Vianello F, Villanova F, Tisato V, Lymperi S, Ho KK, Gomes AR, Marin D, Bonnet D, Apperley J, Lam E, Dazzi F. Bone marrow mesenchymal stromal cells non-selectively protect chronic myeloid leukemia cells from imatinib-induced apoptosis via the CXCR4/CXCL12 axis. Haematologica. 2010 Jul; 95(7):1081-9. PMID: 20179085; PMCID: PMC2895031.
    98. Pedroza-Saavedra A, Lam E, Esquivel-Guadarrama F, Gutierrez-Xicotencatl L. The human papillomavirus type 16 E5 oncoprotein synergizes with EGF-receptor signaling to enhance cell cycle progression and the down-regulation of p27(Kip1). Virology. 2010 Apr 25; 400(1):44-52. PMID: 20144468.
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    99. Kwok JM, Peck B, Monteiro LJ, Schwenen HD, Millour J, Coombes RC, Myatt SS, Lam E. FOXM1 confers acquired cisplatin resistance in breast cancer cells. Mol Cancer Res. 2010 Jan; 8(1):24-34. PMID: 20068070; PMCID: PMC2809047.
    100. Myatt SS, Wang J, Monteiro LJ, Christian M, Ho KK, Fusi L, Dina RE, Brosens JJ, Ghaem-Maghami S, Lam E. Definition of microRNAs that repress expression of the tumor suppressor gene FOXO1 in endometrial cancer. Cancer Res. 2010 Jan 01; 70(1):367-77. PMID: 20028871; PMCID: PMC2880714.
    101. Leitao B, Jones MC, Fusi L, Higham J, Lee Y, Takano M, Goto T, Christian M, Lam E, Brosens JJ. Silencing of the JNK pathway maintains progesterone receptor activity in decidualizing human endometrial stromal cells exposed to oxidative stress signals. FASEB J. 2010 May; 24(5):1541-51. PMID: 20026682; PMCID: PMC2857868.
    102. Hussain F, Wang J, Ahmed R, Guest SK, Lam E, Stamp G, El-Bahrawy M. The expression of IL-8 and IL-8 receptors in pancreatic adenocarcinomas and pancreatic neuroendocrine tumours. Cytokine. 2010 Feb; 49(2):134-40. PMID: 20005738.
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    103. Hartman J, Lam E, Gustafsson JA, Ström A. Hes-6, an inhibitor of Hes-1, is regulated by 17beta-estradiol and promotes breast cancer cell proliferation. Breast Cancer Res. 2009; 11(6):R79. PMID: 19891787; PMCID: PMC2815541.
    104. Watanabe N, Lam E. Bax Inhibitor-1, a conserved cell death suppressor, is a key molecular switch downstream from a variety of biotic and abiotic stress signals in plants. Int J Mol Sci. 2009 Jul 10; 10(7):3149-67. PMID: 19742129; PMCID: PMC2738916.
    105. Francis RE, Myatt SS, Krol J, Hartman J, Peck B, McGovern UB, Wang J, Guest SK, Filipovic A, Gojis O, Palmieri C, Peston D, Shousha S, Yu Q, Sicinski P, Coombes RC, Lam E. FoxM1 is a downstream target and marker of HER2 overexpression in breast cancer. Int J Oncol. 2009 Jul; 35(1):57-68. PMID: 19513552; PMCID: PMC3065068.
    106. Albergaria A, Paredes J, Sousa B, Milanezi F, Carneiro V, Bastos J, Costa S, Vieira D, Lopes N, Lam E, Lunet N, Schmitt F. Expression of FOXA1 and GATA-3 in breast cancer: the prognostic significance in hormone receptor-negative tumours. Breast Cancer Res. 2009; 11(3):R40. PMID: 19549328; PMCID: PMC2716509.
    107. Ho KK, Rosivatz E, Gunn RM, Smith ME, Stavropoulou AV, Rosivatz E, Numbere MG, Wong JB, Lafitte VG, Behrendt JM, Myatt SS, Hailes HC, Woscholski R, Lam E. The novel molecule 2-[5-(2-chloroethyl)-2-acetoxy-benzyl]-4-(2-chloroethyl)-phenyl acetate inhibits phosphoinositide 3-kinase/Akt/mammalian target of rapamycin signalling through JNK activation in cancer cells. FEBS J. 2009 Aug; 276(15):4037-50. PMID: 19549188.
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    108. Luo C, Durgin BG, Watanabe N, Lam E. Defining the functional network of epigenetic regulators in Arabidopsis thaliana. Mol Plant. 2009 Jul; 2(4):661-74. PMID: 19825647.
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    109. McGovern UB, Francis RE, Peck B, Guest SK, Wang J, Myatt SS, Krol J, Kwok JM, Polychronis A, Coombes RC, Lam E. Gefitinib (Iressa) represses FOXM1 expression via FOXO3a in breast cancer. Mol Cancer Ther. 2009 Mar; 8(3):582-91. PMID: 19276163.
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    110. Batlle A, Papadopoulou V, Gomes AR, Willimott S, Melo JV, Naresh K, Lam E, Wagner SD. CD40 and B-cell receptor signalling induce MAPK family members that can either induce or repress Bcl-6 expression. Mol Immunol. 2009 May; 46(8-9):1727-35. PMID: 19268365.
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    111. Luo C, Lam E. Chromatin charting: global mapping of epigenetic effects. Methods Mol Biol. 2009; 553:127-39. PMID: 19588104.
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    112. Brosens JJ, Wilson MS, Lam E. FOXO transcription factors: from cell fate decisions to regulation of human female reproduction. Adv Exp Med Biol. 2009; 665:227-41. PMID: 20429428.
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    113. Essafi A, Gomes AR, Pomeranz KM, Zwolinska AK, Varshochi R, McGovern UB, Lam E. Studying the subcellular localization and DNA-binding activity of FoxO transcription factors, downstream effectors of PI3K/Akt. Methods Mol Biol. 2009; 462:201-11. PMID: 19160671.
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    114. Nordigården A, Kraft M, Eliasson P, Labi V, Lam E, Villunger A, Jönsson JI. BH3-only protein Bim more critical than Puma in tyrosine kinase inhibitor-induced apoptosis of human leukemic cells and transduced hematopoietic progenitors carrying oncogenic FLT3. Blood. 2009 Mar 05; 113(10):2302-11. PMID: 19064725; PMCID: PMC3272395.
    115. Gomes AR, Brosens JJ, Lam E. Resist or die: FOXO transcription factors determine the cellular response to chemotherapy. Cell Cycle. 2008 Oct; 7(20):3133-6. PMID: 18927504.
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    116. Fernández de Mattos S, Villalonga P, Clardy J, Lam E. FOXO3a mediates the cytotoxic effects of cisplatin in colon cancer cells. Mol Cancer Ther. 2008 Oct; 7(10):3237-46. PMID: 18852127; PMCID: PMC2748241.
    117. Hui RC, Gomes AR, Constantinidou D, Costa JR, Karadedou CT, Fernandez de Mattos S, Wymann MP, Brosens JJ, Schulze A, Lam E. The forkhead transcription factor FOXO3a increases phosphoinositide-3 kinase/Akt activity in drug-resistant leukemic cells through induction of PIK3CA expression. Mol Cell Biol. 2008 Oct; 28(19):5886-98. PMID: 18644865; PMCID: PMC2547013.
    118. Kwok JM, Myatt SS, Marson CM, Coombes RC, Constantinidou D, Lam E. Thiostrepton selectively targets breast cancer cells through inhibition of forkhead box M1 expression. Mol Cancer Ther. 2008 Jul; 7(7):2022-32. PMID: 18645012.
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    119. Cloke B, Huhtinen K, Fusi L, Kajihara T, Yliheikkilä M, Ho KK, Teklenburg G, Lavery S, Jones MC, Trew G, Kim JJ, Lam E, Cartwright JE, Poutanen M, Brosens JJ. The androgen and progesterone receptors regulate distinct gene networks and cellular functions in decidualizing endometrium. Endocrinology. 2008 Sep; 149(9):4462-74. PMID: 18511503.
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    120. Li SK, Smith DK, Leung WY, Cheung AM, Lam E, Dimri GP, Yao KM. FoxM1c counteracts oxidative stress-induced senescence and stimulates Bmi-1 expression. J Biol Chem. 2008 Jun 13; 283(24):16545-53. PMID: 18408007; PMCID: PMC2423239.
    121. Hui RC, Francis RE, Guest SK, Costa JR, Gomes AR, Myatt SS, Brosens JJ, Lam E. Doxorubicin activates FOXO3a to induce the expression of multidrug resistance gene ABCB1 (MDR1) in K562 leukemic cells. Mol Cancer Ther. 2008 Mar; 7(3):670-8. PMID: 18347152.
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    122. Myatt SS, Lam E. Targeting FOXM1. Nat Rev Cancer. 2008 Mar; 8(3):242. PMID: 18297052.
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    123. Mahmoudi N, Enns R, Amar J, AlAli J, Lam E, Telford J. Biliary brush cytology: factors associated with positive yields on biliary brush cytology. World J Gastroenterol. 2008 Jan 28; 14(4):569-73. PMID: 18203289; PMCID: PMC2681148.
    124. Jovtchev G, Watanabe K, Pecinka A, Rosin FM, Mette MF, Lam E, Schubert I. Size and number of tandem repeat arrays can determine somatic homologous pairing of transgene loci mediated by epigenetic modifications in Arabidopsis thaliana nuclei. Chromosoma. 2008 Jun; 117(3):267-76. PMID: 18200447.
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    125. Ho KK, Anderson AA, Rosivatz E, Lam E, Woscholski R, Mann DJ. Identification of cyclin A2 as the downstream effector of the nuclear phosphatidylinositol 4,5-bisphosphate signaling network. J Biol Chem. 2008 Feb 29; 283(9):5477-85. PMID: 18077453.
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    126. Krol J, Francis RE, Albergaria A, Sunters A, Polychronis A, Coombes RC, Lam E. The transcription factor FOXO3a is a crucial cellular target of gefitinib (Iressa) in breast cancer cells. Mol Cancer Ther. 2007 Dec; 6(12 Pt 1):3169-79. PMID: 18089711.
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    127. Watanabe N, Lam E. BAX inhibitor-1 modulates endoplasmic reticulum stress-mediated programmed cell death in Arabidopsis. J Biol Chem. 2008 Feb 08; 283(6):3200-10. PMID: 18039663.
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    128. Myatt SS, Lam E. The emerging roles of forkhead box (Fox) proteins in cancer. Nat Rev Cancer. 2007 Nov; 7(11):847-59. PMID: 17943136.
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    129. Qu X, Lam E, Doughman YQ, Chen Y, Chou YT, Lam M, Turakhia M, Dunwoodie SL, Watanabe M, Xu B, Duncan SA, Yang YC. Cited2, a coactivator of HNF4alpha, is essential for liver development. EMBO J. 2007 Oct 31; 26(21):4445-56. PMID: 17932483; PMCID: PMC2063472.
    130. Glassford J, Rabin N, Lam E, Yong KL. Functional regulation of D-type cyclins by insulin-like growth factor-I and serum in multiple myeloma cells. Br J Haematol. 2007 Oct; 139(2):243-54. PMID: 17897300.
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    131. Feroze-Zaidi F, Fusi L, Takano M, Higham J, Salker MS, Goto T, Edassery S, Klingel K, Boini KM, Palmada M, Kamps R, Groothuis PG, Lam E, Smith SK, Lang F, Sharkey AM, Brosens JJ. Role and regulation of the serum- and glucocorticoid-regulated kinase 1 in fertile and infertile human endometrium. Endocrinology. 2007 Oct; 148(10):5020-9. PMID: 17640988.
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    132. Takano M, Lu Z, Goto T, Fusi L, Higham J, Francis J, Withey A, Hardt J, Cloke B, Stavropoulou AV, Ishihara O, Lam E, Unterman TG, Brosens JJ, Kim JJ. Transcriptional cross talk between the forkhead transcription factor forkhead box O1A and the progesterone receptor coordinates cell cycle regulation and differentiation in human endometrial stromal cells. Mol Endocrinol. 2007 Oct; 21(10):2334-49. PMID: 17609436.
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    133. Delpuech O, Griffiths B, East P, Essafi A, Lam E, Burgering B, Downward J, Schulze A. Induction of Mxi1-SR alpha by FOXO3a contributes to repression of Myc-dependent gene expression. Mol Cell Biol. 2007 Jul; 27(13):4917-30. PMID: 17452451; PMCID: PMC1951505.
    134. Zhao C, Matthews J, Tujague M, Wan J, Ström A, Toresson G, Lam E, Cheng G, Gustafsson JA, Dahlman-Wright K. Estrogen receptor beta2 negatively regulates the transactivation of estrogen receptor alpha in human breast cancer cells. Cancer Res. 2007 Apr 15; 67(8):3955-62. PMID: 17440111.
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    135. Myatt SS, Lam E. Promiscuous and lineage-specific roles of cell cycle regulators in haematopoiesis. Cell Div. 2007 Feb 12; 2:6. PMID: 17295909; PMCID: PMC1802072.
    136. Ramasamy R, Fazekasova H, Lam E, Soeiro I, Lombardi G, Dazzi F. Mesenchymal stem cells inhibit dendritic cell differentiation and function by preventing entry into the cell cycle. Transplantation. 2007 Jan 15; 83(1):71-6. PMID: 17220794.
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    137. Rosivatz E, Matthews JG, McDonald NQ, Mulet X, Ho KK, Lossi N, Schmid AC, Mirabelli M, Pomeranz KM, Erneux C, Lam E, Vilar R, Woscholski R. A small molecule inhibitor for phosphatase and tensin homologue deleted on chromosome 10 (PTEN). ACS Chem Biol. 2006 Dec 15; 1(12):780-90. PMID: 17240976.
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    138. Birkenkamp KU, Essafi A, van der Vos KE, da Costa M, Hui RC, Holstege F, Koenderman L, Lam E, Coffer PJ. FOXO3a induces differentiation of Bcr-Abl-transformed cells through transcriptional down-regulation of Id1. J Biol Chem. 2007 Jan 26; 282(4):2211-20. PMID: 17132628.
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    139. van Gorp AG, Pomeranz KM, Birkenkamp KU, Hui RC, Lam E, Coffer PJ. Chronic protein kinase B (PKB/c-akt) activation leads to apoptosis induced by oxidative stress-mediated Foxo3a transcriptional up-regulation. Cancer Res. 2006 Nov 15; 66(22):10760-9. PMID: 17108112.
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    140. Muñoz-Fontela C, Marcos-Villar L, Gallego P, Arroyo J, Da Costa M, Pomeranz KM, Lam E, Rivas C. Latent protein LANA2 from Kaposi's sarcoma-associated herpesvirus interacts with 14-3-3 proteins and inhibits FOXO3a transcription factor. J Virol. 2007 Feb; 81(3):1511-6. PMID: 17108038; PMCID: PMC1797526.
    141. Jones MC, Fusi L, Higham JH, Abdel-Hafiz H, Horwitz KB, Lam E, Brosens JJ. Regulation of the SUMO pathway sensitizes differentiating human endometrial stromal cells to progesterone. Proc Natl Acad Sci U S A. 2006 Oct 31; 103(44):16272-7. PMID: 17053081; PMCID: PMC1637572.
    142. Alao JP, Stavropoulou AV, Lam E, Coombes RC. Role of glycogen synthase kinase 3 beta (GSK3beta) in mediating the cytotoxic effects of the histone deacetylase inhibitor trichostatin A (TSA) in MCF-7 breast cancer cells. Mol Cancer. 2006 Oct 03; 5:40. PMID: 17018141; PMCID: PMC1592505.
    143. Krietsch T, Fernandes MS, Kero J, Lösel R, Heyens M, Lam E, Huhtaniemi I, Brosens JJ, Gellersen B. Human homologs of the putative G protein-coupled membrane progestin receptors (mPRalpha, beta, and gamma) localize to the endoplasmic reticulum and are not activated by progesterone. Mol Endocrinol. 2006 Dec; 20(12):3146-64. PMID: 16959873.
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    144. Shore AM, White PC, Hui RC, Essafi A, Lam E, Rowe M, Brennan P. Epstein-Barr virus represses the FoxO1 transcription factor through latent membrane protein 1 and latent membrane protein 2A. J Virol. 2006 Nov; 80(22):11191-9. PMID: 16943287; PMCID: PMC1642148.
    145. Lee MY, Zhou Y, Lung RW, Chye ML, Yip WK, Zee SY, Lam E. Expression of viral capsid protein antigen against Epstein-Barr virus in plastids of Nicotiana tabacum cv. SR1. Biotechnol Bioeng. 2006 Aug 20; 94(6):1129-37. PMID: 16586511.
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    146. Leyton J, Alao JP, Da Costa M, Stavropoulou AV, Latigo JR, Perumal M, Pillai R, He Q, Atadja P, Lam E, Workman P, Vigushin DM, Aboagye EO. In vivo biological activity of the histone deacetylase inhibitor LAQ824 is detectable with 3'-deoxy-3'-[18F]fluorothymidine positron emission tomography. Cancer Res. 2006 Aug 01; 66(15):7621-9. PMID: 16885362.
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    147. Soeiro I, Mohamedali A, Romanska HM, Lea NC, Child ES, Glassford J, Orr SJ, Roberts C, Naresh KN, Lalani el-N, Mann DJ, Watson RJ, Thomas NS, Lam E. p27Kip1 and p130 cooperate to regulate hematopoietic cell proliferation in vivo. Mol Cell Biol. 2006 Aug; 26(16):6170-84. PMID: 16880527; PMCID: PMC1592787.
    148. Madureira PA, Varshochi R, Constantinidou D, Francis RE, Coombes RC, Yao KM, Lam E. The Forkhead box M1 protein regulates the transcription of the estrogen receptor alpha in breast cancer cells. J Biol Chem. 2006 Sep 01; 281(35):25167-76. PMID: 16809346.
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    149. Kajihara T, Jones M, Fusi L, Takano M, Feroze-Zaidi F, Pirianov G, Mehmet H, Ishihara O, Higham JM, Lam E, Brosens JJ. Differential expression of FOXO1 and FOXO3a confers resistance to oxidative cell death upon endometrial decidualization. Mol Endocrinol. 2006 Oct; 20(10):2444-55. PMID: 16709600.
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    150. Belkacemi L, Lam E, Caldwell JD, Siemens DR, Graham CH. Stimulation of human breast carcinoma cell invasiveness and urokinase plasminogen activator activity by glucose deprivation. Exp Cell Res. 2006 Jun 10; 312(10):1685-92. PMID: 16564525.
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    151. Hills FA, Abrahams VM, González-Timón B, Francis J, Cloke B, Hinkson L, Rai R, Mor G, Regan L, Sullivan M, Lam E, Brosens JJ. Heparin prevents programmed cell death in human trophoblast. Mol Hum Reprod. 2006 Apr; 12(4):237-43. PMID: 16556679.
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    152. Watanabe N, Lam E. Arabidopsis Bax inhibitor-1 functions as an attenuator of biotic and abiotic types of cell death. Plant J. 2006 Mar; 45(6):884-94. PMID: 16507080.
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    153. Alao JP, Stavropoulou AV, Lam E, Coombes RC, Vigushin DM. Histone deacetylase inhibitor, trichostatin A induces ubiquitin-dependent cyclin D1 degradation in MCF-7 breast cancer cells. Mol Cancer. 2006 Feb 20; 5:8. PMID: 16504004; PMCID: PMC1397858.
    154. Alao JP, Gamble SC, Stavropoulou AV, Pomeranz KM, Lam E, Coombes RC, Vigushin DM. The cyclin D1 proto-oncogene is sequestered in the cytoplasm of mammalian cancer cell lines. Mol Cancer. 2006 Feb 17; 5:7. PMID: 16503970; PMCID: PMC1388232.
    155. Brosens JJ, Lam E, Parker MG. Inflammation and sex steroid receptors: a motif for change. Cell. 2006 Feb 10; 124(3):466-8. PMID: 16469693.
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    156. Zhou YX, Lee MY, Ng JM, Chye ML, Yip WK, Zee SY, Lam E. A truncated hepatitis E virus ORF2 protein expressed in tobacco plastids is immunogenic in mice. World J Gastroenterol. 2006 Jan 14; 12(2):306-12. PMID: 16482635; PMCID: PMC4066044.
    157. Sunters A, Madureira PA, Pomeranz KM, Aubert M, Brosens JJ, Cook SJ, Burgering BM, Coombes RC, Lam E. Paclitaxel-induced nuclear translocation of FOXO3a in breast cancer cells is mediated by c-Jun NH2-terminal kinase and Akt. Cancer Res. 2006 Jan 01; 66(1):212-20. PMID: 16397234.
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    158. Watanabe K, Pecinka A, Meister A, Schubert I, Lam E. DNA hypomethylation reduces homologous pairing of inserted tandem repeat arrays in somatic nuclei of Arabidopsis thaliana. Plant J. 2005 Nov; 44(4):531-40. PMID: 16262704.
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    159. Madureira PA, Matos P, Soeiro I, Dixon LK, Simas JP, Lam E. Murine gamma-herpesvirus 68 latency protein M2 binds to Vav signaling proteins and inhibits B-cell receptor-induced cell cycle arrest and apoptosis in WEHI-231 B cells. J Biol Chem. 2005 Nov 11; 280(45):37310-8. PMID: 16150693.
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    160. Glassford J, Vigorito E, Soeiro I, Madureira PA, Zoumpoulidou G, Brosens JJ, Turner M, Lam E. Phosphatidylinositol 3-kinase is required for the transcriptional activation of cyclin D2 in BCR activated primary mouse B lymphocytes. Eur J Immunol. 2005 Sep; 35(9):2748-61. PMID: 16114097.
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    161. Labied S, Kajihara T, Madureira PA, Fusi L, Jones MC, Higham JM, Varshochi R, Francis JM, Zoumpoulidou G, Essafi A, Fernandez de Mattos S, Lam E, Brosens JJ. Progestins regulate the expression and activity of the forkhead transcription factor FOXO1 in differentiating human endometrium. Mol Endocrinol. 2006 Jan; 20(1):35-44. PMID: 16123151.
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    162. Essafi A, Fernández de Mattos S, Hassen YA, Soeiro I, Mufti GJ, Thomas NS, Medema RH, Lam E. Direct transcriptional regulation of Bim by FoxO3a mediates STI571-induced apoptosis in Bcr-Abl-expressing cells. Oncogene. 2005 Mar 31; 24(14):2317-29. PMID: 15688014.
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    163. Dunne PJ, Belaramani L, Fletcher JM, Fernandez de Mattos S, Lawrenz M, Soares MV, Rustin MH, Lam E, Salmon M, Akbar AN. Quiescence and functional reprogramming of Epstein-Barr virus (EBV)-specific CD8+ T cells during persistent infection. Blood. 2005 Jul 15; 106(2):558-65. PMID: 15797994.
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    164. Lo C, Wang N, Lam E. Inducible double-stranded RNA expression activates reversible transcript turnover and stable translational suppression of a target gene in transgenic tobacco. FEBS Lett. 2005 Feb 28; 579(6):1498-502. PMID: 15733863.
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    165. Watanabe N, Lam E. Two Arabidopsis metacaspases AtMCP1b and AtMCP2b are arginine/lysine-specific cysteine proteases and activate apoptosis-like cell death in yeast. J Biol Chem. 2005 Apr 15; 280(15):14691-9. PMID: 15691845.
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    166. Glennie S, Soeiro I, Dyson PJ, Lam E, Dazzi F. Bone marrow mesenchymal stem cells induce division arrest anergy of activated T cells. Blood. 2005 Apr 01; 105(7):2821-7. PMID: 15591115.
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    167. Alao JP, Lam E, Ali S, Buluwela L, Bordogna W, Lockey P, Varshochi R, Stavropoulou AV, Coombes RC, Vigushin DM. Histone deacetylase inhibitor trichostatin A represses estrogen receptor alpha-dependent transcription and promotes proteasomal degradation of cyclin D1 in human breast carcinoma cell lines. Clin Cancer Res. 2004 Dec 01; 10(23):8094-104. PMID: 15585645.
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    168. Zhou Y, Chan JH, Chan AY, Chak RK, Wong EY, Chye ML, Peiris JS, Poon LL, Lam E. Transgenic plant-derived siRNAs can suppress propagation of influenza virus in mammalian cells. FEBS Lett. 2004 Nov 19; 577(3):345-50. PMID: 15556607.
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    169. Varshochi R, Halim F, Sunters A, Alao JP, Madureira PA, Hart SM, Ali S, Vigushin DM, Coombes RC, Lam E. ICI182,780 induces p21Waf1 gene transcription through releasing histone deacetylase 1 and estrogen receptor alpha from Sp1 sites to induce cell cycle arrest in MCF-7 breast cancer cell line. J Biol Chem. 2005 Feb 04; 280(5):3185-96. PMID: 15557281.
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    170. Fernández de Mattos S, Essafi A, Soeiro I, Pietersen AM, Birkenkamp KU, Edwards CS, Martino A, Nelson BH, Francis JM, Jones MC, Brosens JJ, Coffer PJ, Lam E. FoxO3a and BCR-ABL regulate cyclin D2 transcription through a STAT5/BCL6-dependent mechanism. Mol Cell Biol. 2004 Nov; 24(22):10058-71. PMID: 15509806; PMCID: PMC525464.
    171. Vigorito E, Bardi G, Glassford J, Lam E, Clayton E, Turner M. Vav-dependent and vav-independent phosphatidylinositol 3-kinase activation in murine B cells determined by the nature of the stimulus. J Immunol. 2004 Sep 01; 173(5):3209-14. PMID: 15322182.
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    172. Rainer TH, Griffith JF, Lam E, Lam PK, Metreweli C. Comparison of thoracic ultrasound, clinical acumen, and radiography in patients with minor chest injury. J Trauma. 2004 Jun; 56(6):1211-3. PMID: 15211127.
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    173. Zoumpoulidou G, Jones MC, Fernandez de Mattos S, Francis JM, Fusi L, Lee YS, Christian M, Varshochi R, Lam E, Brosens JJ. Convergence of interferon-gamma and progesterone signaling pathways in human endometrium: role of PIASy (protein inhibitor of activated signal transducer and activator of transcription-y). Mol Endocrinol. 2004 Aug; 18(8):1988-99. PMID: 15155784.
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    174. Palmieri C, Lam E, Vigushin D, Coombes RC. Value of SERMs in postmenopausal women. Lancet. 2004 May 01; 363(9419):1477-8. PMID: 15121421.
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    175. Gamble SC, Odontiadis M, Waxman J, Westbrook JA, Dunn MJ, Wait R, Lam E, Bevan CL. Androgens target prohibitin to regulate proliferation of prostate cancer cells. Oncogene. 2004 Apr 15; 23(17):2996-3004. PMID: 14968116.
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    176. Brosens JJ, Tullet J, Varshochi R, Lam E. Steroid receptor action. Best Pract Res Clin Obstet Gynaecol. 2004 Apr; 18(2):265-83. PMID: 15157642.
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    177. Lam E. Controlled cell death, plant survival and development. Nat Rev Mol Cell Biol. 2004 Apr; 5(4):305-15. PMID: 15071555.
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    178. Palmieri C, Lam E, Mansi J, MacDonald C, Shousha S, Madden P, Omoto Y, Sunters A, Warner M, Gustafsson JA, Coombes RC. The expression of ER beta cx in human breast cancer and the relationship to endocrine therapy and survival. Clin Cancer Res. 2004 Apr 01; 10(7):2421-8. PMID: 15073120.
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    179. Watanabe N, Lam E. Recent advance in the study of caspase-like proteases and Bax inhibitor-1 in plants: their possible roles as regulator of programmed cell death. Mol Plant Pathol. 2004 Jan 01; 5(1):65-70. PMID: 20565583.
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    180. Ng DS, Xie C, Maguire GF, Zhu X, Ugwu F, Lam E, Connelly PW. Hypertriglyceridemia in lecithin-cholesterol acyltransferase-deficient mice is associated with hepatic overproduction of triglycerides, increased lipogenesis, and improved glucose tolerance. J Biol Chem. 2004 Feb 27; 279(9):7636-42. PMID: 14668345.
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    181. Mohamedali A, Soeiro I, Lea NC, Glassford J, Banerji L, Mufti GJ, Lam E, Thomas NS. Cyclin D2 controls B cell progenitor numbers. J Leukoc Biol. 2003 Dec; 74(6):1139-43. PMID: 14612431.
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    182. Zhao C, Lam E, Sunters A, Enmark E, De Bella MT, Coombes RC, Gustafsson JA, Dahlman-Wright K. Expression of estrogen receptor beta isoforms in normal breast epithelial cells and breast cancer: regulation by methylation. Oncogene. 2003 Oct 23; 22(48):7600-6. PMID: 14576822.
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    183. Sunters A, Fernández de Mattos S, Stahl M, Brosens JJ, Zoumpoulidou G, Saunders CA, Coffer PJ, Medema RH, Coombes RC, Lam E. FoxO3a transcriptional regulation of Bim controls apoptosis in paclitaxel-treated breast cancer cell lines. J Biol Chem. 2003 Dec 12; 278(50):49795-805. PMID: 14527951.
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    184. del Pozo O, Lam E. Expression of the baculovirus p35 protein in tobacco affects cell death progression and compromises N gene-mediated disease resistance response to Tobacco mosaic virus. Mol Plant Microbe Interact. 2003 Jun; 16(6):485-94. PMID: 12795375.
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    185. Lagrange T, Hakimi MA, Pontier D, Courtois F, Alcaraz JP, Grunwald D, Lam E, Lerbs-Mache S. Transcription factor IIB (TFIIB)-related protein (pBrp), a plant-specific member of the TFIIB-related protein family. Mol Cell Biol. 2003 May; 23(9):3274-86. PMID: 12697827; PMCID: PMC153204.
    186. Glassford J, Soeiro I, Skarell SM, Banerji L, Holman M, Klaus GG, Kadowaki T, Koyasu S, Lam E. BCR targets cyclin D2 via Btk and the p85alpha subunit of PI3-K to induce cell cycle progression in primary mouse B cells. Oncogene. 2003 Apr 17; 22(15):2248-59. PMID: 12700661.
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    187. Lea NC, Orr SJ, Stoeber K, Williams GH, Lam E, Ibrahim MA, Mufti GJ, Thomas NS. Commitment point during G0-->G1 that controls entry into the cell cycle. Mol Cell Biol. 2003 Apr; 23(7):2351-61. PMID: 12640120; PMCID: PMC150729.
    188. Pontier D, Privat I, Trifa Y, Zhou JM, Klessig DF, Lam E. Differential regulation of TGA transcription factors by post-transcriptional control. Plant J. 2002 Dec; 32(5):641-53. PMID: 12472682.
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    189. Fernández de Mattos S, Lam E, Tauler A. An E2F-binding site mediates the activation of the proliferative isoform of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase by phosphatidylinositol 3-kinase. Biochem J. 2002 Nov 15; 368(Pt 1):283-91. PMID: 12139485; PMCID: PMC1222960.
    190. Schmidt M, Fernandez de Mattos S, van der Horst A, Klompmaker R, Kops GJ, Lam E, Burgering BM, Medema RH. Cell cycle inhibition by FoxO forkhead transcription factors involves downregulation of cyclin D. Mol Cell Biol. 2002 Nov; 22(22):7842-52. PMID: 12391153; PMCID: PMC134724.
    191. Chopra S, Fernandez De Mattos S, Lam E, Mann DJ. Jab1 co-activation of c-Jun is abrogated by the serine 10-phosphorylated form of p27Kip1. J Biol Chem. 2002 Sep 06; 277(36):32413-6. PMID: 12119282.
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    192. Pontier D, Mittler R, Lam E. Mechanism of cell death and disease resistance induction by transgenic expression of bacterio-opsin. Plant J. 2002 Jun; 30(5):499-509. PMID: 12047625.
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    193. Barnouin K, Dubuisson ML, Child ES, Fernandez de Mattos S, Glassford J, Medema RH, Mann DJ, Lam E. H2O2 induces a transient multi-phase cell cycle arrest in mouse fibroblasts through modulating cyclin D and p21Cip1 expression. J Biol Chem. 2002 Apr 19; 277(16):13761-70. PMID: 11827966.
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