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Triple artemisinin-based combination therapies for malaria: a timely solution to counter antimalarial drug resistance. Lancet Infect Dis. 2022 Mar 08.
Chen I, Hsiang MS. PMID: 35276063.
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G6PD Polymorphisms and Hemolysis After Antimalarial Treatment With Low Single-Dose Primaquine: A Pooled Analysis of Six African Clinical Trials. Front Genet. 2021; 12:645688.
Sepúlveda N, Grignard L, Curry J, Mahey L, Bastiaens GJH, Tiono AB, Okebe J, Coulibaly SA, Gonçalves BP, Affara M, Ouédraogo A, Bougouma EC, Sanou GS, Nébié I, Lanke K, Sirima SB, Dicko A, d'Alessandro U, Clark TG, Campino S, Chen I, Eziefula AC, Gosling R, Bousema T, Drakeley C. PMID: 33897764; PMCID: PMC8062977.
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Persistence of mRNA indicative of Plasmodium falciparum ring-stage parasites 42 days after artemisinin and non-artemisinin combination therapy in naturally infected Malians. Malar J. 2021 Jan 09; 20(1):34.
Mahamar A, Lanke K, Graumans W, Diawara H, Sanogo K, Diarra K, Niambele SM, Gosling R, Drakeley C, Chen I, Dicko A, Bousema T, Roh ME. PMID: 33422068; PMCID: PMC7797096.
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HumansAnimals
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Efficacy of single dose primaquine with artemisinin combination therapy on P. falciparum gametocytes and transmission: A WWARN individual patient meta-analysis. J Infect Dis. 2020 Aug 11.
Stepniewska K, Humphreys GS, Gonçalves BP, Craig E, Gosling R, Guerin PJ, Price RN, Barnes KI, Raman J, Smit MR, D'Alessandro U, Stone WJR, Bjorkman A, Samuels AM, Arroyo-Arroyo MI, Bastiaens GJH, Brown JM, Dicko A, El-Sayed BB, Elzaki SG, Eziefula AC, Kariuki S, Kwambai TK, Maestre AE, Martensson A, Mosha D, Mwaiswelo RO, Ngasala BE, Okebe J, Roh ME, Sawa P, Tiono AB, Chen I, Drakeley CJ, Bousema T. PMID: 32778875.
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5 Fields:
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Malaria eradication - Authors' reply. Lancet. 2020 04 25; 395(10233):e73.
Chen I, Dondorp A, Gosling R, Harvard K, Tulloch J. PMID: 32334710.
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1 Fields:
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Humans
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District-level approach for tailoring and targeting interventions: a new path for malaria control and elimination. Malar J. 2020 Mar 30; 19(1):125.
Gosling R, Chimumbwa J, Uusiku P, Rossi S, Ntuku H, Harvard K, White C, Tatarsky A, Chandramohan D, Chen I. PMID: 32228595; PMCID: PMC7106871.
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3 Fields:
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HumansPHPublic Health
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Assessing the role of the private sector in surveillance for malaria elimination in Haiti and the Dominican Republic: a qualitative study. Malar J. 2019 Dec 05; 18(1):408.
Sidibe A, Maglior A, Cueto C, Chen I, Le Menach A, Chang MA, Eisele TP, Andrinopolous K, Cherubin J, Lemoine JF, Bennett A. PMID: 31806025; PMCID: PMC6896765.
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1 Fields:
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HumansPHPublic Health
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CYP2D6 Polymorphisms and the Safety and Gametocytocidal Activity of Single-Dose Primaquine for Plasmodium falciparum. Antimicrob Agents Chemother. 2019 10; 63(10).
Pett H, Bradley J, Okebe J, Dicko A, Tiono AB, Gonçalves BP, Stone W, Chen I, Lanke K, Neuvonen M, Mustaniemi AL, Eziefula AC, Gosling R, D'Alessandro U, Drakeley C, Niemi M, Bousema T. PMID: 31383656; PMCID: PMC6761544.
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2 Fields:
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HumansAnimalsCTClinical Trials
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Malaria eradication within a generation: ambitious, achievable, and necessary. Lancet. 2019 09 21; 394(10203):1056-1112.
Feachem RGA, Chen I, Akbari O, Bertozzi-Villa A, Bhatt S, Binka F, Boni MF, Buckee C, Dieleman J, Dondorp A, Eapen A, Sekhri Feachem N, Filler S, Gething P, Gosling R, Haakenstad A, Harvard K, Hatefi A, Jamison D, Jones KE, Karema C, Kamwi RN, Lal A, Larson E, Lees M, Lobo NF, Micah AE, Moonen B, Newby G, Ning X, Pate M, Quiñones M, Roh M, Rolfe B, Shanks D, Singh B, Staley K, Tulloch J, Wegbreit J, Woo HJ, Mpanju-Shumbusho W. PMID: 31511196.
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69 Fields:
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HumansPHPublic Health
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What is community engagement and how can it drive malaria elimination? Case studies and stakeholder interviews. Malar J. 2019 Jul 17; 18(1):245.
Baltzell K, Harvard K, Hanley M, Gosling R, Chen I. PMID: 31315631; PMCID: PMC6637529.
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10 Fields:
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HumansPHPublic Health
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Predicting the likelihood and intensity of mosquito infection from sex specific Plasmodium falciparum gametocyte density. Elife. 2018 05 31; 7.
Bradley J, Stone W, Da DF, Morlais I, Dicko A, Cohuet A, Guelbeogo WM, Mahamar A, Nsango S, Soumaré HM, Diawara H, Lanke K, Graumans W, Siebelink-Stoter R, van de Vegte-Bolmer M, Chen I, Tiono A, Gonçalves BP, Gosling R, Sauerwein RW, Drakeley C, Churcher TS, Bousema T. PMID: 29848446; PMCID: PMC6013255.
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31 Fields:
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HumansAnimalsCells
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The Lancet Commission on malaria eradication. Lancet. 2018 04 21; 391(10130):1556-1558.
Chen I, Cooney R, Feachem RGA, Lal A, Mpanju-Shumbusho W. PMID: 29673872.
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6 Fields:
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HumansPHPublic Health
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Safety of Single-Dose Primaquine in G6PD-Deficient and G6PD-Normal Males in Mali Without Malaria: An Open-Label, Phase 1, Dose-Adjustment Trial. J Infect Dis. 2018 03 28; 217(8):1298-1308.
Chen I, Diawara H, Mahamar A, Sanogo K, Keita S, Kone D, Diarra K, Djimde M, Keita M, Brown J, Roh ME, Hwang J, Pett H, Murphy M, Niemi M, Greenhouse B, Bousema T, Gosling R, Dicko A. PMID: 29342267; PMCID: PMC5974787.
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PubMed Mentions:
8 Fields:
Translation:
Humans
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Low risk of recurrence following artesunate-Sulphadoxine-pyrimethamine plus primaquine for uncomplicated Plasmodium falciparum and Plasmodium vivax infections in the Republic of the Sudan. Malar J. 2018 Mar 16; 17(1):117.
Hamid MMA, Thriemer K, Elobied ME, Mahgoub NS, Boshara SA, Elsafi HMH, Gumaa SA, Hamid T, Abdelbagi H, Basheir HM, Marfurt J, Chen I, Gosling R, Price RN, Ley B. PMID: 29548285; PMCID: PMC5857106.
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1 Fields:
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Humans
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Efficacy and safety of primaquine and methylene blue for prevention of Plasmodium falciparum transmission in Mali: a phase 2, single-blind, randomised controlled trial. Lancet Infect Dis. 2018 06; 18(6):627-639.
Dicko A, Roh ME, Diawara H, Mahamar A, Soumare HM, Lanke K, Bradley J, Sanogo K, Kone DT, Diarra K, Keita S, Issiaka D, Traore SF, McCulloch C, Stone WJR, Hwang J, Müller O, Brown JM, Srinivasan V, Drakeley C, Gosling R, Chen I, Bousema T. PMID: 29422384; PMCID: PMC5968371.
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24 Fields:
Translation:
HumansAnimalsCTClinical Trials
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Malaria risk factors and care-seeking behaviour within the private sector among high-risk populations in Vietnam: a qualitative study. Malar J. 2017 10 16; 16(1):414.
Chen I, Thanh HNT, Lover A, Thao PT, Luu TV, Thang HN, Thang ND, Neukom J, Bennett A. PMID: 29037242; PMCID: PMC5644094.
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4 Fields:
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Humans
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A Molecular Assay to Quantify Male and Female Plasmodium falciparum Gametocytes: Results From 2 Randomized Controlled Trials Using Primaquine for Gametocyte Clearance. J Infect Dis. 2017 08 15; 216(4):457-467.
Stone W, Sawa P, Lanke K, Rijpma S, Oriango R, Nyaurah M, Osodo P, Osoti V, Mahamar A, Diawara H, Woestenenk R, Graumans W, van de Vegte-Bolmer M, Bradley J, Chen I, Brown J, Siciliano G, Alano P, Gosling R, Dicko A, Drakeley C, Bousema T. PMID: 28931236; PMCID: PMC5853855.
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29 Fields:
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HumansAnimalsCells
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Barriers to routine G6PD testing prior to treatment with primaquine. Malar J. 2017 08 10; 16(1):329.
Ley B, Thriemer K, Jaswal J, Poirot E, Alam MS, Phru CS, Khan WA, Dysoley L, Qi G, Kheong CC, Shamsudin UK, Chen I, Hwang J, Gosling R, Price RN. PMID: 28797255; PMCID: PMC5553859.
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11 Fields:
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Humans
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Mass Drug Administration for Malaria: A Means to What end? J Infect Dis. 2016 12 15; 214(12):1790-1792.
Chen I, Gosling R, Drakeley C, Bousema T. PMID: 27923945.
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1 Fields:
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HumansPHPublic Health
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Comparison of molecular quantification of Plasmodium falciparum gametocytes by Pfs25 qRT-PCR and QT-NASBA in relation to mosquito infectivity. Malar J. 2016 Nov 08; 15(1):539.
Pett H, Gonçalves BP, Dicko A, Nébié I, Tiono AB, Lanke K, Bradley J, Chen I, Diawara H, Mahamar A, Soumare HM, Traore SF, Baber I, Sirima SB, Sauerwein R, Brown J, Gosling R, Felger I, Drakeley C, Bousema T. PMID: 27821171; PMCID: PMC5100312.
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18 Fields:
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HumansAnimals
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Primaquine to reduce transmission of Plasmodium falciparum malaria in Mali: a single-blind, dose-ranging, adaptive randomised phase 2 trial. Lancet Infect Dis. 2016 Jun; 16(6):674-684.
Dicko A, Brown JM, Diawara H, Baber I, Mahamar A, Soumare HM, Sanogo K, Koita F, Keita S, Traore SF, Chen I, Poirot E, Hwang J, McCulloch C, Lanke K, Pett H, Niemi M, Nosten F, Bousema T, Gosling R. PMID: 26906747.
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45 Fields:
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HumansAnimalsCTClinical Trials
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"Asymptomatic" Malaria: A Chronic and Debilitating Infection That Should Be Treated. PLoS Med. 2016 Jan; 13(1):e1001942.
Chen I, Clarke SE, Gosling R, Hamainza B, Killeen G, Magill A, O'Meara W, Price RN, Riley EM. PMID: 26783752; PMCID: PMC4718522.
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PubMed Mentions:
108 Fields:
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Humans
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Availability and quality of anti-malarials among private sector outlets in Myanmar in 2012: results from a large, community-based, cross-sectional survey before a large-scale intervention. Malar J. 2015 Jul 14; 14:269.
Khin HS, Chen I, White C, Sudhinaraset M, McFarland W, Littrell M, Montagu D, Aung T. PMID: 26169498; PMCID: PMC4501098.
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8 Fields:
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Humans
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Review of mass drug administration for malaria and its operational challenges. Am J Trop Med Hyg. 2015 Jul; 93(1):125-134.
Newby G, Hwang J, Koita K, Chen I, Greenwood B, von Seidlein L, Shanks GD, Slutsker L, Kachur SP, Wegbreit J, Ippolito MM, Poirot E, Gosling R. PMID: 26013371; PMCID: PMC4497884.
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PubMed Mentions:
88 Fields:
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HumansPHPublic Health
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An assessment of the supply, programmatic use, and regulatory issues of single low-dose primaquine as a Plasmodium falciparum gametocytocide for sub-Saharan Africa. Malar J. 2015 May 15; 14:204.
Chen I, Poirot E, Newman M, Kandula D, Shah R, Hwang J, Cohen JM, Gosling R, Rooney L. PMID: 25971688; PMCID: PMC4446184.
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PubMed Mentions:
14 Fields:
Translation:
HumansAnimals
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Improving uptake and use of malaria rapid diagnostic tests in the context of artemisinin drug resistance containment in eastern Myanmar: an evaluation of incentive schemes among informal private healthcare providers. Malar J. 2015 Mar 06; 14:105.
Aung T, White C, Montagu D, McFarland W, Hlaing T, Khin HS, San AK, Briegleb C, Chen I, Sudhinaraset M. PMID: 25885581; PMCID: PMC4355503.
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19 Fields:
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Humans
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Cost-effectiveness analysis of malaria rapid diagnostic test incentive schemes for informal private healthcare providers in Myanmar. Malar J. 2015 Feb 05; 14:55.
Chen IT, Aung T, Thant HN, Sudhinaraset M, Kahn JG. PMID: 25653121; PMCID: PMC4334415.
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8 Fields:
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Humans
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Assessment of therapeutic responses to gametocytocidal drugs in Plasmodium falciparum malaria. Malar J. 2014 Dec 09; 13:483.
White NJ, Ashley EA, Recht J, Delves MJ, Ruecker A, Smithuis FM, Eziefula AC, Bousema T, Drakeley C, Chotivanich K, Imwong M, Pukrittayakamee S, Prachumsri J, Chu C, Andolina C, Bancone G, Hien TT, Mayxay M, Taylor WR, von Seidlein L, Price RN, Barnes KI, Djimdé A, ter Kuile F, Gosling R, Chen I, Dhorda MJ, Stepniewska K, Guérin P, Woodrow CJ, Dondorp AM, Day NP, Nosten FH. PMID: 25486998; PMCID: PMC4295364.
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36 Fields:
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HumansAnimals
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Low-dose primaquine to reduce the transmission of P. falciparum malaria: a roadmap update. Malaria Journal. 2014 Sep 1; 13(Suppl 1):p22.
Chen CI, Drakeley DC, Poirot PE, Hwang HJ, Gosling GR. .
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Pharmacovigilance for single low-dose primaquine: a practical approach. Malaria Journal. 2014 Sep 1; 13(Suppl 1):p72.
Poirot PE, Stergachis SA, ter Kuile tF, Guerin GP, Chen CI, Gosling GR. .
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Targeting Plasmodium falciparum transmission with primaquine: same efficacy, improved safety with a lower dose? Expert Rev Clin Pharmacol. 2014 Nov; 7(6):681-6.
Chen IT, Gosling RD. PMID: 25118908.
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6 Fields:
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HumansAnimals
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Total synthesis of sandresolide B and amphilectolide. Org Lett. 2014 Jan 03; 16(1):166-9.
Chen IT, Baitinger I, Schreyer L, Trauner D. PMID: 24308854.
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1 Fields:
Translation:
Cells
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Ferrous iron-dependent drug delivery enables controlled and selective release of therapeutic agents in vivo. Proc Natl Acad Sci U S A. 2013 Nov 05; 110(45):18244-9.
Deu E, Chen IT, Lauterwasser EM, Valderramos J, Li H, Edgington LE, Renslo AR, Bogyo M. PMID: 24145449; PMCID: PMC3831501.
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PubMed Mentions:
7 Fields:
Translation:
Animals
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Discovery of 5-(arenethynyl) hetero-monocyclic derivatives as potent inhibitors of BCR-ABL including the T315I gatekeeper mutant. Bioorg Med Chem Lett. 2011 Jun 15; 21(12):3743-8.
Thomas M, Huang WS, Wen D, Zhu X, Wang Y, Metcalf CA, Liu S, Chen I, Romero J, Zou D, Sundaramoorthi R, Li F, Qi J, Cai L, Zhou T, Commodore L, Xu Q, Keats J, Wang F, Wardwell S, Ning Y, Snodgrass JT, Broudy MI, Russian K, Iuliucci J, Rivera VM, Sawyer TK, Dalgarno DC, Clackson T, Shakespeare WC. PMID: 21561767.
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3 Fields:
Translation:
AnimalsCells
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Discovery of 3-[2-(imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide (AP24534), a potent, orally active pan-inhibitor of breakpoint cluster region-abelson (BCR-ABL) kinase including the T315I gatekeeper mutant. J Med Chem. 2010 Jun 24; 53(12):4701-19.
Huang WS, Metcalf CA, Sundaramoorthi R, Wang Y, Zou D, Thomas RM, Zhu X, Cai L, Wen D, Liu S, Romero J, Qi J, Chen I, Banda G, Lentini SP, Das S, Xu Q, Keats J, Wang F, Wardwell S, Ning Y, Snodgrass JT, Broudy MI, Russian K, Zhou T, Commodore L, Narasimhan NI, Mohemmad QK, Iuliucci J, Rivera VM, Dalgarno DC, Sawyer TK, Clackson T, Shakespeare WC. PMID: 20513156.
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PubMed Mentions:
74 Fields:
Translation:
AnimalsCells
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Total synthesis of (-)-archazolid B. J Am Chem Soc. 2007 Jul 25; 129(29):8960-1.
Roethle PA, Chen IT, Trauner D. PMID: 17595091; PMCID: PMC6407884.
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PubMed Mentions:
17 Fields:
Translation:
Cells