 Ingrid Chen, PhD
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| Title(s) | Assistant Professor, Epidemiology & Biostatistics |
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| School | School of Medicine |
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| Phone | 415-476-5599 |
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| vCard | Download vCard |
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 Biography | University of California, San Francisco | MS | 08/2013 | Global Health Sciences | | University of California, Berkeley | PhD | 05/2011 | Organic chemistry | | Yale University | BS | 05/2004 | Chemistry |
Overview Ingrid Chen is an Assistant Professor in the Department of Epidemiology and Biostatistics at the University of California San Francisco (UCSF), and an Associate Director of Eradication Research within the UCSF Global Health Group’s Malaria Elimination Initiative (MEI). Trained as an organic chemist, Ingrid has been conducting malaria research since 2011, with interdisciplinary expertise spanning from drug discovery and clinical trials (phase 1 and 2) to implementation, cost-effectiveness, antimalarial delivery within the informal private sector, and more.
Since joining the MEI in 2013, Ingrid spent three years leading the Primaquine Rollout Group, and now leads the MEI’s eradication research portfolio of work, including the Antiparasite Rollout Group (APROG) and the Lancet Commission on Malaria Eradication, as well as the development of background papers to inform policy and implementation.
Bibliographic
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Bradley J, Stone W, Da DF, Morlais I, Dicko A, Cohuet A, Guelbeogo WM, Mahamar A, Nsango S, Soumaré HM, Diawara H, Lanke K, Graumans W, Siebelink-Stoter R, van de Vegte-Bolmer M, Chen I, Tiono A, Gonçalves BP, Gosling R, Sauerwein RW, Drakeley C, Churcher TS, Bousema T. Predicting the likelihood and intensity of mosquito infection from sex specific Plasmodium falciparum gametocyte density. Elife. 2018 05 31; 7. PMID: 29848446.
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Chen I, Cooney R, Feachem RGA, Lal A, Mpanju-Shumbusho W. The Lancet Commission on malaria eradication. Lancet. 2018 04 21; 391(10130):1556-1558. PMID: 29673872.
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Chen I, Diawara H, Mahamar A, Sanogo K, Keita S, Kone D, Diarra K, Djimde M, Keita M, Brown J, Roh ME, Hwang J, Pett H, Murphy M, Niemi M, Greenhouse B, Bousema T, Gosling R, Dicko A. Safety of Single-Dose Primaquine in G6PD-Deficient and G6PD-Normal Males in Mali Without Malaria: An Open-Label, Phase 1, Dose-Adjustment Trial. J Infect Dis. 2018 03 28; 217(8):1298-1308. PMID: 29342267.
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Hamid MMA, Thriemer K, Elobied ME, Mahgoub NS, Boshara SA, Elsafi HMH, Gumaa SA, Hamid T, Abdelbagi H, Basheir HM, Marfurt J, Chen I, Gosling R, Price RN, Ley B. Low risk of recurrence following artesunate-Sulphadoxine-pyrimethamine plus primaquine for uncomplicated Plasmodium falciparum and Plasmodium vivax infections in the Republic of the Sudan. Malar J. 2018 Mar 16; 17(1):117. PMID: 29548285.
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Dicko A, Roh ME, Diawara H, Mahamar A, Soumare HM, Lanke K, Bradley J, Sanogo K, Kone DT, Diarra K, Keita S, Issiaka D, Traore SF, McCulloch C, Stone WJR, Hwang J, Müller O, Brown JM, Srinivasan V, Drakeley C, Gosling R, Chen I, Bousema T. Efficacy and safety of primaquine and methylene blue for prevention of Plasmodium falciparum transmission in Mali: a phase 2, single-blind, randomised controlled trial. Lancet Infect Dis. 2018 06; 18(6):627-639. PMID: 29422384.
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Chen I, Thanh HNT, Lover A, Thao PT, Luu TV, Thang HN, Thang ND, Neukom J, Bennett A. Malaria risk factors and care-seeking behaviour within the private sector among high-risk populations in Vietnam: a qualitative study. Malar J. 2017 10 16; 16(1):414. PMID: 29037242.
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Stone W, Sawa P, Lanke K, Rijpma S, Oriango R, Nyaurah M, Osodo P, Osoti V, Mahamar A, Diawara H, Woestenenk R, Graumans W, van de Vegte-Bolmer M, Bradley J, Chen I, Brown J, Siciliano G, Alano P, Gosling R, Dicko A, Drakeley C, Bousema T. A Molecular Assay to Quantify Male and Female Plasmodium falciparum Gametocytes: Results From 2 Randomized Controlled Trials Using Primaquine for Gametocyte Clearance. J Infect Dis. 2017 08 15; 216(4):457-467. PMID: 28931236.
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Ley B, Thriemer K, Jaswal J, Poirot E, Alam MS, Phru CS, Khan WA, Dysoley L, Qi G, Kheong CC, Shamsudin UK, Chen I, Hwang J, Gosling R, Price RN. Barriers to routine G6PD testing prior to treatment with primaquine. Malar J. 2017 08 10; 16(1):329. PMID: 28797255.
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Chen I, Gosling R, Drakeley C, Bousema T. Mass Drug Administration for Malaria: A Means to What end? J Infect Dis. 2016 12 15; 214(12):1790-1792. PMID: 27923945.
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Pett H, Gonçalves BP, Dicko A, Nébié I, Tiono AB, Lanke K, Bradley J, Chen I, Diawara H, Mahamar A, Soumare HM, Traore SF, Baber I, Sirima SB, Sauerwein R, Brown J, Gosling R, Felger I, Drakeley C, Bousema T. Comparison of molecular quantification of Plasmodium falciparum gametocytes by Pfs25 qRT-PCR and QT-NASBA in relation to mosquito infectivity. Malar J. 2016 Nov 08; 15(1):539. PMID: 27821171.
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Dicko A, Brown JM, Diawara H, Baber I, Mahamar A, Soumare HM, Sanogo K, Koita F, Keita S, Traore SF, Chen I, Poirot E, Hwang J, McCulloch C, Lanke K, Pett H, Niemi M, Nosten F, Bousema T, Gosling R. Primaquine to reduce transmission of Plasmodium falciparum malaria in Mali: a single-blind, dose-ranging, adaptive randomised phase 2 trial. Lancet Infect Dis. 2016 Jun; 16(6):674-684. PMID: 26906747.
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Chen I, Clarke SE, Gosling R, Hamainza B, Killeen G, Magill A, O'Meara W, Price RN, Riley EM. "Asymptomatic" Malaria: A Chronic and Debilitating Infection That Should Be Treated. PLoS Med. 2016 Jan; 13(1):e1001942. PMID: 26783752.
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Khin HS, Chen I, White C, Sudhinaraset M, McFarland W, Littrell M, Montagu D, Aung T. Availability and quality of anti-malarials among private sector outlets in Myanmar in 2012: results from a large, community-based, cross-sectional survey before a large-scale intervention. Malar J. 2015 Jul 14; 14:269. PMID: 26169498.
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Newby G, Hwang J, Koita K, Chen I, Greenwood B, von Seidlein L, Shanks GD, Slutsker L, Kachur SP, Wegbreit J, Ippolito MM, Poirot E, Gosling R. Review of mass drug administration for malaria and its operational challenges. Am J Trop Med Hyg. 2015 Jul; 93(1):125-134. PMID: 26013371.
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Chen I, Poirot E, Newman M, Kandula D, Shah R, Hwang J, Cohen JM, Gosling R, Rooney L. An assessment of the supply, programmatic use, and regulatory issues of single low-dose primaquine as a Plasmodium falciparum gametocytocide for sub-Saharan Africa. Malar J. 2015 May 15; 14:204. PMID: 25971688.
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Aung T, White C, Montagu D, McFarland W, Hlaing T, Khin HS, San AK, Briegleb C, Chen I, Sudhinaraset M. Improving uptake and use of malaria rapid diagnostic tests in the context of artemisinin drug resistance containment in eastern Myanmar: an evaluation of incentive schemes among informal private healthcare providers. Malar J. 2015 Mar 06; 14:105. PMID: 25885581.
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Chen IT, Aung T, Thant HN, Sudhinaraset M, Kahn JG. Cost-effectiveness analysis of malaria rapid diagnostic test incentive schemes for informal private healthcare providers in Myanmar. Malar J. 2015 Feb 05; 14:55. PMID: 25653121.
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White NJ, Ashley EA, Recht J, Delves MJ, Ruecker A, Smithuis FM, Eziefula AC, Bousema T, Drakeley C, Chotivanich K, Imwong M, Pukrittayakamee S, Prachumsri J, Chu C, Andolina C, Bancone G, Hien TT, Mayxay M, Taylor WR, von Seidlein L, Price RN, Barnes KI, Djimdé A, ter Kuile F, Gosling R, Chen I, Dhorda MJ, Stepniewska K, Guérin P, Woodrow CJ, Dondorp AM, Day NP, Nosten FH. Assessment of therapeutic responses to gametocytocidal drugs in Plasmodium falciparum malaria. Malar J. 2014 Dec 09; 13:483. PMID: 25486998.
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Ingrid Chen, Chris Drakeley, Eugenie Poirot, Jimee Hwang, Roly Gosling. Low-dose primaquine to reduce the transmission of P. falciparum malaria: a roadmap update. Malaria Journal. 2014 Sep 1; 13(Suppl 1):p22.
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Eugenie Poirot, Andy Stergachis, Feiko ter Kuile, Philippe J Guerin, Ingrid Chen, Roland Gosling. Pharmacovigilance for single low-dose primaquine: a practical approach. Malaria Journal. 2014 Sep 1; 13(Suppl 1):p72.
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Chen IT, Gosling RD. Targeting Plasmodium falciparum transmission with primaquine: same efficacy, improved safety with a lower dose? Expert Rev Clin Pharmacol. 2014 Nov; 7(6):681-6. PMID: 25118908.
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Chen IT, Baitinger I, Schreyer L, Trauner D. Total synthesis of sandresolide B and amphilectolide. Org Lett. 2014 Jan 03; 16(1):166-9. PMID: 24308854.
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Deu E, Chen IT, Lauterwasser EM, Valderramos J, Li H, Edgington LE, Renslo AR, Bogyo M. Ferrous iron-dependent drug delivery enables controlled and selective release of therapeutic agents in vivo. Proc Natl Acad Sci U S A. 2013 Nov 05; 110(45):18244-9. PMID: 24145449.
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Thomas M, Huang WS, Wen D, Zhu X, Wang Y, Metcalf CA, Liu S, Chen I, Romero J, Zou D, Sundaramoorthi R, Li F, Qi J, Cai L, Zhou T, Commodore L, Xu Q, Keats J, Wang F, Wardwell S, Ning Y, Snodgrass JT, Broudy MI, Russian K, Iuliucci J, Rivera VM, Sawyer TK, Dalgarno DC, Clackson T, Shakespeare WC. Discovery of 5-(arenethynyl) hetero-monocyclic derivatives as potent inhibitors of BCR-ABL including the T315I gatekeeper mutant. Bioorg Med Chem Lett. 2011 Jun 15; 21(12):3743-8. PMID: 21561767.
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Huang WS, Metcalf CA, Sundaramoorthi R, Wang Y, Zou D, Thomas RM, Zhu X, Cai L, Wen D, Liu S, Romero J, Qi J, Chen I, Banda G, Lentini SP, Das S, Xu Q, Keats J, Wang F, Wardwell S, Ning Y, Snodgrass JT, Broudy MI, Russian K, Zhou T, Commodore L, Narasimhan NI, Mohemmad QK, Iuliucci J, Rivera VM, Dalgarno DC, Sawyer TK, Clackson T, Shakespeare WC. Discovery of 3-[2-(imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide (AP24534), a potent, orally active pan-inhibitor of breakpoint cluster region-abelson (BCR-ABL) kinase including the T315I gatekeeper mutant. J Med Chem. 2010 Jun 24; 53(12):4701-19. PMID: 20513156.
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Roethle PA, Chen IT, Trauner D. Total synthesis of (-)-archazolid B. J Am Chem Soc. 2007 Jul 25; 129(29):8960-1. PMID: 17595091.
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