Ingrid Chen, PhD

Title(s)Assistant Professor, Epidemiology & Biostatistics
SchoolSchool of Medicine
Address550 16th. Street
San Francisco CA 94158
Phone415-476-5599
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoMS08/2013Global Health Sciences
    University of California, BerkeleyPhD05/2011Organic chemistry
    Yale UniversityBS05/2004Chemistry

    Collapse Overview 
    Collapse Overview
    Ingrid Chen is an Assistant Professor in the Department of Epidemiology and Biostatistics at the University of California San Francisco (UCSF). Trained as an organic chemist, Ingrid has been conducting malaria research since 2011, with interdisciplinary expertise spanning from drug discovery and clinical trials (phase 1 and 2) to implementation, cost-effectiveness, antimalarial delivery within the informal private sector, and more.

    Since joining the UCSF's Malaria Elimination Initiative (MEI) in 2013, Ingrid led the Primaquine Rollout Group, the Antiparasite Rollout Group (APROG), and the scientific sections of the Lancet Commission on Malaria Eradication. Her current research focuses on spatial repellents, a product class that can accelerate the trajectory to malaria eradication while addressing other vector-borne diseases.

    Collapse Research 
    Collapse Research Activities and Funding
    Spatial repellents to reduce the outdoor transmission of malaria
    NIH K01AI156182Jan 1, 2021 - Dec 31, 2023
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. G6PD Polymorphisms and Hemolysis After Antimalarial Treatment With Low Single-Dose Primaquine: A Pooled Analysis of Six African Clinical Trials. Front Genet. 2021; 12:645688. Sepúlveda N, Grignard L, Curry J, Mahey L, Bastiaens GJH, Tiono AB, Okebe J, Coulibaly SA, Gonçalves BP, Affara M, Ouédraogo A, Bougouma EC, Sanou GS, Nébié I, Lanke K, Sirima SB, Dicko A, d'Alessandro U, Clark TG, Campino S, Chen I, Eziefula AC, Gosling R, Bousema T, Drakeley C. PMID: 33897764.
      View in: PubMed   Mentions:
    2. Persistence of mRNA indicative of Plasmodium falciparum ring-stage parasites 42 days after artemisinin and non-artemisinin combination therapy in naturally infected Malians. Malar J. 2021 Jan 09; 20(1):34. Hanna RF, Ward TJ, Chow DS, Lagana SM, Moreira RK, Emond JC, Weintraub JL, Prince MR, Mahamar A, Lanke K, Graumans W, Diawara H, Sanogo K, Diarra K, Niambele SM, Gosling R, Drakeley C, Chen I, Dicko A, Bousema T, Roh ME. PMID: 33422068; PMCID: PMC7797096.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    3. Efficacy of single dose primaquine with artemisinin combination therapy on P. falciparum gametocytes and transmission: A WWARN individual patient meta-analysis. J Infect Dis. 2020 Aug 11. Stepniewska K, Humphreys GS, Gonçalves BP, Craig E, Gosling R, Guerin PJ, Price RN, Barnes KI, Raman J, Smit MR, D'Alessandro U, Stone WJR, Bjorkman A, Samuels AM, Arroyo-Arroyo MI, Bastiaens GJH, Brown JM, Dicko A, El-Sayed BB, Elzaki SG, Eziefula AC, Kariuki S, Kwambai TK, Maestre AE, Martensson A, Mosha D, Mwaiswelo RO, Ngasala BE, Okebe J, Roh ME, Sawa P, Tiono AB, Chen I, Drakeley CJ, Bousema T. PMID: 32778875.
      View in: PubMed   Mentions: 5     Fields:    
    4. Malaria eradication - Authors' reply. Lancet. 2020 04 25; 395(10233):e73. Chen I, Dondorp A, Gosling R, Harvard K, Tulloch J. PMID: 32334710.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    5. District-level approach for tailoring and targeting interventions: a new path for malaria control and elimination. Malar J. 2020 Mar 30; 19(1):125. Gosling R, Chimumbwa J, Uusiku P, Rossi S, Ntuku H, Harvard K, White C, Tatarsky A, Chandramohan D, Chen I. PMID: 32228595.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansPHPublic Health
    6. Assessing the role of the private sector in surveillance for malaria elimination in Haiti and the Dominican Republic: a qualitative study. Malar J. 2019 Dec 05; 18(1):408. Sidibe A, Maglior A, Cueto C, Chen I, Le Menach A, Chang MA, Eisele TP, Andrinopolous K, Cherubin J, Lemoine JF, Bennett A. PMID: 31806025.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansPHPublic Health
    7. CYP2D6 Polymorphisms and the Safety and Gametocytocidal Activity of Single-Dose Primaquine for Plasmodium falciparum. Antimicrob Agents Chemother. 2019 10; 63(10). Pett H, Bradley J, Okebe J, Dicko A, Tiono AB, Gonçalves BP, Stone W, Chen I, Lanke K, Neuvonen M, Mustaniemi AL, Eziefula AC, Gosling R, D'Alessandro U, Drakeley C, Niemi M, Bousema T. PMID: 31383656.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCTClinical Trials
    8. Malaria eradication within a generation: ambitious, achievable, and necessary. Lancet. 2019 09 21; 394(10203):1056-1112. Feachem RGA, Chen I, Akbari O, Bertozzi-Villa A, Bhatt S, Binka F, Boni MF, Buckee C, Dieleman J, Dondorp A, Eapen A, Sekhri Feachem N, Filler S, Gething P, Gosling R, Haakenstad A, Harvard K, Hatefi A, Jamison D, Jones KE, Karema C, Kamwi RN, Lal A, Larson E, Lees M, Lobo NF, Micah AE, Moonen B, Newby G, Ning X, Pate M, Quiñones M, Roh M, Rolfe B, Shanks D, Singh B, Staley K, Tulloch J, Wegbreit J, Woo HJ, Mpanju-Shumbusho W. PMID: 31511196.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansPHPublic Health
    9. What is community engagement and how can it drive malaria elimination? Case studies and stakeholder interviews. Malar J. 2019 Jul 17; 18(1):245. Baltzell K, Harvard K, Hanley M, Gosling R, Chen I. PMID: 31315631.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansPHPublic Health
    10. Predicting the likelihood and intensity of mosquito infection from sex specific Plasmodium falciparum gametocyte density. Elife. 2018 05 31; 7. Bradley J, Stone W, Da DF, Morlais I, Dicko A, Cohuet A, Guelbeogo WM, Mahamar A, Nsango S, Soumaré HM, Diawara H, Lanke K, Graumans W, Siebelink-Stoter R, van de Vegte-Bolmer M, Chen I, Tiono A, Gonçalves BP, Gosling R, Sauerwein RW, Drakeley C, Churcher TS, Bousema T. PMID: 29848446.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    11. The Lancet Commission on malaria eradication. Lancet. 2018 04 21; 391(10130):1556-1558. Chen I, Cooney R, Feachem RGA, Lal A, Mpanju-Shumbusho W. PMID: 29673872.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansPHPublic Health
    12. Safety of Single-Dose Primaquine in G6PD-Deficient and G6PD-Normal Males in Mali Without Malaria: An Open-Label, Phase 1, Dose-Adjustment Trial. J Infect Dis. 2018 03 28; 217(8):1298-1308. Chen I, Diawara H, Mahamar A, Sanogo K, Keita S, Kone D, Diarra K, Djimde M, Keita M, Brown J, Roh ME, Hwang J, Pett H, Murphy M, Niemi M, Greenhouse B, Bousema T, Gosling R, Dicko A. PMID: 29342267.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    13. Low risk of recurrence following artesunate-Sulphadoxine-pyrimethamine plus primaquine for uncomplicated Plasmodium falciparum and Plasmodium vivax infections in the Republic of the Sudan. Malar J. 2018 Mar 16; 17(1):117. Hamid MMA, Thriemer K, Elobied ME, Mahgoub NS, Boshara SA, Elsafi HMH, Gumaa SA, Hamid T, Abdelbagi H, Basheir HM, Marfurt J, Chen I, Gosling R, Price RN, Ley B. PMID: 29548285.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    14. Efficacy and safety of primaquine and methylene blue for prevention of Plasmodium falciparum transmission in Mali: a phase 2, single-blind, randomised controlled trial. Lancet Infect Dis. 2018 06; 18(6):627-639. Dicko A, Roh ME, Diawara H, Mahamar A, Soumare HM, Lanke K, Bradley J, Sanogo K, Kone DT, Diarra K, Keita S, Issiaka D, Traore SF, McCulloch C, Stone WJR, Hwang J, Müller O, Brown JM, Srinivasan V, Drakeley C, Gosling R, Chen I, Bousema T. PMID: 29422384.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCTClinical Trials
    15. Malaria risk factors and care-seeking behaviour within the private sector among high-risk populations in Vietnam: a qualitative study. Malar J. 2017 10 16; 16(1):414. Chen I, Thanh HNT, Lover A, Thao PT, Luu TV, Thang HN, Thang ND, Neukom J, Bennett A. PMID: 29037242.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    16. A Molecular Assay to Quantify Male and Female Plasmodium falciparum Gametocytes: Results From 2 Randomized Controlled Trials Using Primaquine for Gametocyte Clearance. J Infect Dis. 2017 08 15; 216(4):457-467. Stone W, Sawa P, Lanke K, Rijpma S, Oriango R, Nyaurah M, Osodo P, Osoti V, Mahamar A, Diawara H, Woestenenk R, Graumans W, van de Vegte-Bolmer M, Bradley J, Chen I, Brown J, Siciliano G, Alano P, Gosling R, Dicko A, Drakeley C, Bousema T. PMID: 28931236.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    17. Barriers to routine G6PD testing prior to treatment with primaquine. Malar J. 2017 08 10; 16(1):329. Ley B, Thriemer K, Jaswal J, Poirot E, Alam MS, Phru CS, Khan WA, Dysoley L, Qi G, Kheong CC, Shamsudin UK, Chen I, Hwang J, Gosling R, Price RN. PMID: 28797255.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    18. Mass Drug Administration for Malaria: A Means to What end? J Infect Dis. 2016 12 15; 214(12):1790-1792. Chen I, Gosling R, Drakeley C, Bousema T. PMID: 27923945.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansPHPublic Health
    19. Comparison of molecular quantification of Plasmodium falciparum gametocytes by Pfs25 qRT-PCR and QT-NASBA in relation to mosquito infectivity. Malar J. 2016 Nov 08; 15(1):539. Pett H, Gonçalves BP, Dicko A, Nébié I, Tiono AB, Lanke K, Bradley J, Chen I, Diawara H, Mahamar A, Soumare HM, Traore SF, Baber I, Sirima SB, Sauerwein R, Brown J, Gosling R, Felger I, Drakeley C, Bousema T. PMID: 27821171.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimals
    20. Primaquine to reduce transmission of Plasmodium falciparum malaria in Mali: a single-blind, dose-ranging, adaptive randomised phase 2 trial. Lancet Infect Dis. 2016 Jun; 16(6):674-684. Dicko A, Brown JM, Diawara H, Baber I, Mahamar A, Soumare HM, Sanogo K, Koita F, Keita S, Traore SF, Chen I, Poirot E, Hwang J, McCulloch C, Lanke K, Pett H, Niemi M, Nosten F, Bousema T, Gosling R. PMID: 26906747.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCTClinical Trials
    21. "Asymptomatic" Malaria: A Chronic and Debilitating Infection That Should Be Treated. PLoS Med. 2016 Jan; 13(1):e1001942. Chen I, Clarke SE, Gosling R, Hamainza B, Killeen G, Magill A, O'Meara W, Price RN, Riley EM. PMID: 26783752.
      View in: PubMed   Mentions: 108     Fields:    Translation:Humans
    22. Availability and quality of anti-malarials among private sector outlets in Myanmar in 2012: results from a large, community-based, cross-sectional survey before a large-scale intervention. Malar J. 2015 Jul 14; 14:269. Khin HS, Chen I, White C, Sudhinaraset M, McFarland W, Littrell M, Montagu D, Aung T. PMID: 26169498.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    23. Review of mass drug administration for malaria and its operational challenges. Am J Trop Med Hyg. 2015 Jul; 93(1):125-134. Newby G, Hwang J, Koita K, Chen I, Greenwood B, von Seidlein L, Shanks GD, Slutsker L, Kachur SP, Wegbreit J, Ippolito MM, Poirot E, Gosling R. PMID: 26013371.
      View in: PubMed   Mentions: 88     Fields:    Translation:HumansPHPublic Health
    24. An assessment of the supply, programmatic use, and regulatory issues of single low-dose primaquine as a Plasmodium falciparum gametocytocide for sub-Saharan Africa. Malar J. 2015 May 15; 14:204. Chen I, Poirot E, Newman M, Kandula D, Shah R, Hwang J, Cohen JM, Gosling R, Rooney L. PMID: 25971688.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimals
    25. Improving uptake and use of malaria rapid diagnostic tests in the context of artemisinin drug resistance containment in eastern Myanmar: an evaluation of incentive schemes among informal private healthcare providers. Malar J. 2015 Mar 06; 14:105. Aung T, White C, Montagu D, McFarland W, Hlaing T, Khin HS, San AK, Briegleb C, Chen I, Sudhinaraset M. PMID: 25885581.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    26. Cost-effectiveness analysis of malaria rapid diagnostic test incentive schemes for informal private healthcare providers in Myanmar. Malar J. 2015 Feb 05; 14:55. Chen IT, Aung T, Thant HN, Sudhinaraset M, Kahn JG. PMID: 25653121.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    27. Assessment of therapeutic responses to gametocytocidal drugs in Plasmodium falciparum malaria. Malar J. 2014 Dec 09; 13:483. White NJ, Ashley EA, Recht J, Delves MJ, Ruecker A, Smithuis FM, Eziefula AC, Bousema T, Drakeley C, Chotivanich K, Imwong M, Pukrittayakamee S, Prachumsri J, Chu C, Andolina C, Bancone G, Hien TT, Mayxay M, Taylor WR, von Seidlein L, Price RN, Barnes KI, Djimdé A, ter Kuile F, Gosling R, Chen I, Dhorda MJ, Stepniewska K, Guérin P, Woodrow CJ, Dondorp AM, Day NP, Nosten FH. PMID: 25486998.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimals
    28. Low-dose primaquine to reduce the transmission of P. falciparum malaria: a roadmap update. Malaria Journal. 2014 Sep 1; 13(Suppl 1):p22. Chen CI, Drakeley DC, Poirot PE, Hwang HJ, Gosling GR. .
      View in: Publisher Site   Mentions:
    29. Pharmacovigilance for single low-dose primaquine: a practical approach. Malaria Journal. 2014 Sep 1; 13(Suppl 1):p72. Poirot PE, Stergachis SA, ter Kuile tF, Guerin GP, Chen CI, Gosling GR. .
      View in: Publisher Site   Mentions:
    30. Targeting Plasmodium falciparum transmission with primaquine: same efficacy, improved safety with a lower dose? Expert Rev Clin Pharmacol. 2014 Nov; 7(6):681-6. Chen IT, Gosling RD. PMID: 25118908.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    31. Total synthesis of sandresolide B and amphilectolide. Org Lett. 2014 Jan 03; 16(1):166-9. Chen IT, Baitinger I, Schreyer L, Trauner D. PMID: 24308854.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    32. Ferrous iron-dependent drug delivery enables controlled and selective release of therapeutic agents in vivo. Proc Natl Acad Sci U S A. 2013 Nov 05; 110(45):18244-9. Deu E, Chen IT, Lauterwasser EM, Valderramos J, Li H, Edgington LE, Renslo AR, Bogyo M. PMID: 24145449.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    33. Discovery of 5-(arenethynyl) hetero-monocyclic derivatives as potent inhibitors of BCR-ABL including the T315I gatekeeper mutant. Bioorg Med Chem Lett. 2011 Jun 15; 21(12):3743-8. Thomas M, Huang WS, Wen D, Zhu X, Wang Y, Metcalf CA, Liu S, Chen I, Romero J, Zou D, Sundaramoorthi R, Li F, Qi J, Cai L, Zhou T, Commodore L, Xu Q, Keats J, Wang F, Wardwell S, Ning Y, Snodgrass JT, Broudy MI, Russian K, Iuliucci J, Rivera VM, Sawyer TK, Dalgarno DC, Clackson T, Shakespeare WC. PMID: 21561767.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    34. Discovery of 3-[2-(imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide (AP24534), a potent, orally active pan-inhibitor of breakpoint cluster region-abelson (BCR-ABL) kinase including the T315I gatekeeper mutant. J Med Chem. 2010 Jun 24; 53(12):4701-19. Huang WS, Metcalf CA, Sundaramoorthi R, Wang Y, Zou D, Thomas RM, Zhu X, Cai L, Wen D, Liu S, Romero J, Qi J, Chen I, Banda G, Lentini SP, Das S, Xu Q, Keats J, Wang F, Wardwell S, Ning Y, Snodgrass JT, Broudy MI, Russian K, Zhou T, Commodore L, Narasimhan NI, Mohemmad QK, Iuliucci J, Rivera VM, Dalgarno DC, Sawyer TK, Clackson T, Shakespeare WC. PMID: 20513156.
      View in: PubMed   Mentions: 74     Fields:    Translation:AnimalsCells
    35. Total synthesis of (-)-archazolid B. J Am Chem Soc. 2007 Jul 25; 129(29):8960-1. Roethle PA, Chen IT, Trauner D. PMID: 17595091.
      View in: PubMed   Mentions: 17     Fields:    Translation:Cells
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