Jaspreet Kalra, PhD

Title(s)Postdoctoral Scholar, Cardiovascular Research Inst
SchoolSchool of Medicine
Address555 Mission Bay Blvd South, #212
San Francisco CA 94158
Emailjaspreet.kalra@ucsf.edu
ORCID ORCID Icon0000-0002-3720-8994 Additional info
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    Collapse Biography 
    Collapse Education and Training
    University of California San Francisco, California, United StatesPostdoctoral TrainingPresentVascular Pharmacology and Biology
    University of Virginia, Charlottesville, Virginia, United StatesPostdoctoral Training07/2023Molecular Physiology and Cardiovascular Pharmacology
    BITS Pilani, Hyderabad Campus, IndiaPhD02/2021Cardiovascular Pharmacology
    ISF College of Pharmacy, Moga, Punjab, IndiaM.Pharm09/2014Pharmacology
    SBSPGI Balawala, Dehradun, IndiaB.Pharm06/2012Pharmaceutical Sciences
    Collapse Awards and Honors
    University of Virginia and University of California San Francisco2022  - 2024American Heart Institution
    BITS-Pilani, Hyderabad Campus, India2018  - 2020Council of Scientific and Industrial Research-HRDG, India
    BITS-Pilani, Hyderabad Campus, India2020DST-International Travel Grant
    BITS Pilani, Hyderabad Campus, India2020Best Oral presenter Global Health summit ICONICA 2020, Punjab University Chandigarh India

    Collapse Overview 
    Collapse Overview
    I am interested in studying cardiovascular diseases aimed at unraveling the molecular pathways involved in progression and development of hypertension. Contraction-relaxation cycle in smooth muscle cells and in in-vivo models involved in blood pressure regulation.

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. p90RSK2, a new MLCK mediates contractility in myosin light chain kinase null smooth muscle. Front Physiol. 2023; 14:1228488. Kalra J, Artamonov M, Wang H, Franke A, Markowska Z, Jin L, Derewenda ZS, Ayon RJ, Somlyo A. PMID: 37781225; PMCID: PMC10533999.
      View in: PubMed   Mentions:
    2. p90RSK2, a new MLCK, rescues contractility in myosin light chain kinase null smooth muscle. bioRxiv. 2023 May 22. Kalra J, Artamonov M, Wang H, Franke A, Markowska Z, Jin L, Derewenda ZS, Ayon R, Somlyo A. PMID: 37292593; PMCID: PMC10245941.
      View in: PubMed   Mentions:
    3. FHL5 Controls Vascular Disease-Associated Gene Programs in Smooth Muscle Cells. Circ Res. 2023 04 28; 132(9):1144-1161. Wong D, Auguste G, Lino Cardenas CL, Turner AW, Chen Y, Song Y, Ma L, Perry RN, Aherrahrou R, Kuppusamy M, Yang C, Mosquera JV, Dube CJ, Khan MD, Palmore M, Kalra J, Kavousi M, Peyser PA, Matic L, Hedin U, Manichaikul A, Sonkusare SK, Civelek M, Kovacic JC, Björkegren JLM, Malhotra R, Miller CL. PMID: 37017084; PMCID: PMC10147587.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    4. Crosslink between mutations in mitochondrial genes and brain disorders: implications for mitochondrial-targeted therapeutic interventions. Neural Regen Res. 2023 Jan; 18(1):94-101. Kalra J. PMID: 35799515; PMCID: PMC9241418.
      View in: PubMed   Mentions: 6  
    5. Publisher Correction: High fructose and streptozotocin induced diabetic impairments are mitigated by Indirubin‑3‑hydrazone via downregulation of PKR pathway in Wistar rats. Sci Rep. 2021 Aug 19; 11(1):17152. Udumula MP, Mangali S, Kalra J, Dasari D, Goyal S, Krishna V, Bollareddy SR, Sriram D, Dhar A, Bhat A. PMID: 34413426; PMCID: PMC8376955.
      View in: PubMed   Mentions:    Fields:    
    6. High fructose and streptozotocin induced diabetic impairments are mitigated by Indirubin-3-hydrazone via downregulation of PKR pathway in Wistar rats. Sci Rep. 2021 06 21; 11(1):12924. Udumula MP, Mangali S, Kalra J, Dasari D, Goyal S, Krishna V, Bollareddy SR, Sriram D, Dhar A, Bhat A. PMID: 34155273; PMCID: PMC8217483.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    7. Up-regulation of PKR pathway contributes to L-NAME induced hypertension and renal damage. Heliyon. 2020 Nov; 6(11):e05463. Kalra J, Bhat A, Jadhav KB, Dhar A. PMID: 33294654; PMCID: PMC7689172.
      View in: PubMed   Mentions: 5  
    8. PKR inhibitor imoxin prevents hypertension, endothelial dysfunction and cardiac and vascular remodelling in L-NAME-treated rats. Life Sci. 2020 Dec 01; 262:118436. Kalra J, Dasari D, Bhat A, Mangali S, Goyal SG, Jadhav KB, Dhar A. PMID: 32950570.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    9. Upregulation of PKR pathway mediates glucolipotoxicity induced diabetic cardiomyopathy in vivo in wistar rats and in vitro in cultured cardiomyocytes. Biochem Pharmacol. 2020 07; 177:113948. Mangali S, Bhat A, Jadhav K, Kalra J, Sriram D, Vamsi Krishna Venuganti V, Dhar A. PMID: 32251680.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    10. SGLT1 inhibition boon or bane for diabetes-associated cardiomyopathy. Fundam Clin Pharmacol. 2020 Apr; 34(2):173-188. Kalra J, Mangali SB, Dasari D, Bhat A, Goyal S, Dhar I, Sriram D, Dhar A. PMID: 31698522.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    11. Selective inhibition of PKR improves vascular inflammation and remodelling in high fructose treated primary vascular smooth muscle cells. Biochim Biophys Acta Mol Basis Dis. 2020 03 01; 1866(3):165606. Kalra J, Mangali S, Bhat A, Jadhav K, Dhar A. PMID: 31740405.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    12. Pharmacological evaluation of novel PKR inhibitor indirubin-3-hydrazone in-vitro in cardiac myocytes and in-vivo in wistar rats. Life Sci. 2018 Sep 15; 209:85-96. Udumula MP, Bhat A, Mangali S, Kalra J, Dhar I, Sriram D, Dhar A. PMID: 30076923.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    13. Imoxin attenuates high fructose-induced oxidative stress and apoptosis in renal epithelial cells via downregulation of protein kinase R pathway. Fundam Clin Pharmacol. 2018 Jun; 32(3):297-305. Kalra J, Mangali SB, Bhat A, Dhar I, Udumula MP, Dhar A. PMID: 29430716.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    14. Betulinic acid alleviates dextran sulfate sodium-induced colitis and visceral pain in mice. Naunyn Schmiedebergs Arch Pharmacol. 2018 03; 391(3):285-297. Kalra J, Lingaraju MC, Mathesh K, Kumar D, Parida S, Singh TU, Sharma AK, Kumar D, Tandan SK. PMID: 29279966.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    15. Double-stranded RNA-dependent protein kinase signalling and paradigms of cardiometabolic syndrome. Fundam Clin Pharmacol. 2017 Jun; 31(3):265-279. Kalra J, Dhar A. PMID: 27992964.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    16. Pharmacological evaluation of novel alagebrium analogs as methylglyoxal scavengers in vitro in cardiac myocytes and in vivo in SD rats. Int J Cardiol. 2016 Nov 15; 223:581-589. Dhar A, Udumula MP, Medapi B, Bhat A, Dhar I, Malapati P, Babu MS, Kalra J, Sriram D, Desai KM. PMID: 27561164.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    17. Effect of ursolic acid in attenuating chronic constriction injury-induced neuropathic pain in rats. Fundam Clin Pharmacol. 2016 Dec; 30(6):517-528. Bhat RA, Lingaraju MC, Pathak NN, Kalra J, Kumar D, Kumar D, Tandan SK. PMID: 27414466.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    18. Modulation of LOX and COX pathways via inhibition of amyloidogenesis contributes to mitoprotection against β-amyloid oligomer-induced toxicity in an animal model of Alzheimer's disease in rats. Pharmacol Biochem Behav. 2016 Jul-Aug; 146-147:1-12. Kalra J, Kumar P, Majeed AB, Prakash A. PMID: 27106205.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    19. Effect of Trimeric Myricetin Rhamnoside (TMR) in Carrageenan-induced Inflammation and Caecal Ligation and Puncture-induced Lung Oxidative Stress in Mice. Phytother Res. 2015 Nov; 29(11):1798-805. Latief N, Anand S, Lingaraju MC, Balaganur V, Pathak NN, Kalra J, Kumar D, Bhadoria BK, Tandan SK. PMID: 26343251.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    20. Reducing Aβ load and tau phosphorylation: Emerging perspective for treating Alzheimer's disease. Eur J Pharmacol. 2015 Oct 05; 764:571-581. Kalra J, Khan A. PMID: 26209363.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    21. Cerebroprotective effects of RAS inhibitors: Beyond their cardio-renal actions. J Renin Angiotensin Aldosterone Syst. 2015 Sep; 16(3):459-68. Kalra J, Prakash A, Kumar P, Majeed AB. PMID: 25944853.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimals
    22. Neuroprotective effect of N-acetyl cysteine against streptozotocin-induced memory dysfunction and oxidative damage in rats. J Basic Clin Physiol Pharmacol. 2015 Jan; 26(1):13-23. Prakash A, Kalra JK, Kumar A. PMID: 24756058.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    23. Pharmacological approaches for Alzheimer's disease: neurotransmitter as drug targets. Expert Rev Neurother. 2015 Jan; 15(1):53-71. Prakash A, Kalra J, Mani V, Ramasamy K, Majeed AB. PMID: 25495260.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
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