Jeff Spence, PhD

Photo of Jeff Spence, PhD
Title(s)Assistant Professor, Epidemiology & Biostatistics
SchoolSchool of Medicine
Address513 Parnassus Avenue MSB, #966
San Francisco CA 94143
PronounsHe/Him/His
ORCID ORCID Icon0000-0002-3199-1447 Additional info
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    We primarily develop methods and theory to understand how evolution shapes the genetic architecture of complex traits at different biological scales, but we are also broadly interested in any biological puzzles that present interesting computational or statistical challenges.

    Collapse Biography 
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    Stanford UniversityPostdoc12/2023Genetics
    University of California, BerkeleyPhD05/2019Computational Biology
    Cornell UniversityBA05/2013Biological Sciences, Mathematics

    Collapse Research 

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Longitudinal surface-based morphometry reveals potential MRI biomarkers correlated with multidimensional brain health measures. Brain Imaging Behav. 2026 Jul 13; 20(4). Honea RA, Patel A, Guiler W, D'Esposito M, Chapman SB, Cook LG, Spence JS. PMID: 42437827; PMCID: PMC13357483.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    2. Reductions in posttraumatic stress disorder re-experiencing frequency from repetitive transcranial magnetic stimulation combined with Cognitive Processing Therapy. Int Rev Psychiatry. 2026 Jul 05; 1-11. Petry J, Hoq N, Kapadam L, Morris EE, Bass C, Spence JS, Motes MA, Hart J. PMID: 42402165.
      View in: PubMed   Mentions:    Fields:    
    3. Allele Frequencies at Recessive Disease Genes are Mainly Determined by Pleiotropic Effects in Heterozygotes. Genetics. 2026 Jun 15. Judd J, Spence JP, Milind N, Kachuri L, Witte JS, Pritchard JK. PMID: 42289869.
      View in: PubMed   Mentions:    Fields:    
    4. Improving mental health outcomes through online brain health training in adults with or without mental illness. Front Psychol. 2026; 17:1826717. Laane SA, Cook LG, Spence JS, Chapman SB. PMID: 42325321; PMCID: PMC13277663.
      View in: PubMed   Mentions:
    5. Buffering of gene dosage response curves for human complex traits. Cell Genom. 2026 Jul 08; 6(7):101221. Milind N, Smith CJ, Zhu H, Gjorgjieva T, Spence JP, Pritchard JK. PMID: 42102804.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    6. Measuring and increasing the brain health span across adulthood: a public health imperative. Sci Rep. 2026 May 02; 16(1). Cook LG, Spence JS, Chang Z, Venza EE, Tate A, Robertson IH, D'Esposito M, Ling GSF, Wigginton JG, Chapman SB. PMID: 42069911.
      View in: PubMed   Mentions:    Fields:    Translation:HumansPHPublic Health
    7. Regulatory network topology and the genetic architecture of gene expression. Cell Genom. 2026 Jun 10; 6(6):101219. Aguirre M, Spence JP, Sella G, Pritchard JK. PMID: 42025156.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    8. Large future genetic diversity losses are predicted from conservation indicators even with habitat protection. Proc Natl Acad Sci U S A. 2026 Mar 31; 123(13):e2514371123. Mualim KS, Spence JP, Weiß C, Selmoni O, Lin M, Exposito-Alonso M. PMID: 41886371; PMCID: PMC13037886.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    9. Genetic architectures of brain-related traits are shaped by strong selective constraints. bioRxiv. 2026 Mar 25. Zhu H, Simons YB, Spence JP, Sella G, Pritchard JK. PMID: 41929205; PMCID: PMC13042030.
      View in: PubMed   Mentions:
    10. Predicting the effect of CRISPR-Cas9-based epigenome editing. Elife. 2026 Jan 12; 12. Batra SS, Cabrera A, Spence JP, Goell J, Anand SS, Hilton IB, Song YS. PMID: 41524535; PMCID: PMC12795505.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    11. Causal modelling of gene effects from regulators to programs to traits. Nature. 2026 02; 650(8101):399-408. Ota M, Spence JP, Zeng T, Dann E, Milind N, Marson A, Pritchard JK. PMID: 41372418; PMCID: PMC12893915.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    12. Allele Frequencies at Recessive Disease Genes are Mainly Determined by Pleiotropic Effects in Heterozygotes. bioRxiv. 2025 Dec 09. Judd J, Spence JP, Milind N, Kachuri L, Witte JS, Pritchard JK. PMID: 41573830; PMCID: PMC12822701.
      View in: PubMed   Mentions:
    13. Decadelong low basal ganglia NAA/tCr from elevated tCr supports ATP depletion from mitochondrial dysfunction and neuroinflammation in Gulf War illness. Sci Rep. 2025 Nov 20; 15(1):39741. Cheshkov S, Krishnamurthy LC, Chang A, Baek HM, Ganji S, Babcock E, Spence JS, Briggs RW, Haley RW. PMID: 41266399; PMCID: PMC12634682.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    14. Longitudinal Surface-Based Morphometry Reveals Potential MRI Biomarkers Correlated with Multidimensional Brain Health Measures. Res Sq. 2025 Nov 19. Honea RA, Patel A, Guiler W, D'Esposito M, Chapman SB, Cook LG, Spence JS. PMID: 41333417; PMCID: PMC12668122.
      View in: PubMed   Mentions:
    15. Specificity, length and luck drive gene rankings in association studies. Nature. 2026 01; 649(8098):918-925. Spence JP, Mostafavi H, Ota M, Milind N, Gjorgjieva T, Smith CJ, Simons YB, Sella G, Pritchard JK. PMID: 41193809; PMCID: PMC12823407.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    16. Gene regulatory network structure informs the distribution of perturbation effects. PLoS Comput Biol. 2025 Sep; 21(9):e1013387. Aguirre M, Spence JP, Sella G, Pritchard JK. PMID: 40892899; PMCID: PMC12419648.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    17. Cognitive Training to Increase Resilience. Mil Med. 2025 Sep 01; 190(Supplement_2):640-648. Young LR, Rule G, Lundie M, Zientz J, Terrell KH, Van Vleet T, Tate AM, Spence JS. PMID: 40984139.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    18. Buffering and non-monotonic behavior of gene dosage response curves for human complex traits. medRxiv. 2025 Aug 13. Milind N, Smith CJ, Zhu H, Gjorgjieva T, Spence JP, Pritchard JK. PMID: 40832387; PMCID: PMC12363730.
      View in: PubMed   Mentions:
    19. Estimation of demography and mutation rates from one million haploid genomes. Am J Hum Genet. 2025 09 04; 112(9):2152-2166. Schraiber JG, Spence JP, Edge MD. PMID: 40812314; PMCID: PMC12461025.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    20. Regulatory network topology and the genetic architecture of gene expression. bioRxiv. 2025 Aug 12. Aguirre M, Spence JP, Sella G, Pritchard JK. PMID: 40832275; PMCID: PMC12363847.
      View in: PubMed   Mentions:
    21. Investigating the role of neighborhood socioeconomic status and germline genetics on prostate cancer risk. HGG Adv. 2025 Oct 09; 6(4):100492. Judd J, Spence JP, Pritchard JK, Kachuri L, Witte JS. PMID: 40783788; PMCID: PMC12536654.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    22. Large future genetic diversity losses are predicted even with habitat protection. bioRxiv. 2025 Aug 05. Mualim KS, Spence JP, Weiß C, Selmoni O, Lin M, Exposito-Alonso M. PMID: 39484505; PMCID: PMC11526952.
      View in: PubMed   Mentions:
    23. Haplotype analysis reveals pleiotropic disease associations in the HLA region. Am J Hum Genet. 2025 08 07; 112(8):1833-1851. Smith CJ, Strausz S, FinnGen, Spence JP, Ollila HM, Pritchard JK. PMID: 40645183; PMCID: PMC12414721.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    24. Effect of cue distinctiveness on naming: Evidence from a verbally cued naming paradigm. Cogn Neuropsychol. 2024 Oct-Dec; 41(7-8):359-374. Dugas CS, Motes MA, Chiang HS, Spence JS, Lucas-Mendoza K, Diesing S, Keltner-Dorman E, Hart J. PMID: 40562691.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    25. SMART accelerates rate of cognitive gains in service members with mTBI and PTSD. Front Hum Neurosci. 2025; 19:1542422. Venza E, Spence JS, Zientz J, Devlin C, Bailie J, Darr A, Babakhanyan I, Chapman SB. PMID: 40416902; PMCID: PMC12098106.
      View in: PubMed   Mentions: 1  
    26. Characterizing selection on complex traits through conditional frequency spectra. Genetics. 2025 04 17; 229(4). Patel RA, Weiß CL, Zhu H, Mostafavi H, Simons YB, Spence JP, Pritchard JK. PMID: 39691067; PMCID: PMC12005249.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    27. Predicting the effect of CRISPR-Cas9-based epigenome editing. bioRxiv. 2025 Feb 28. Batra SS, Cabrera A, Spence JP, Goell J, Anand SS, Hilton IB, Song YS. PMID: 37873127; PMCID: PMC10592942.
      View in: PubMed   Mentions:
    28. Causal modeling of gene effects from regulators to programs to traits: integration of genetic associations and Perturb-seq. bioRxiv. 2025 Jan 24. Ota M, Spence JP, Zeng T, Dann E, Marson A, Pritchard JK. PMID: 39896538; PMCID: PMC11785173.
      View in: PubMed   Mentions:
    29. Specificity, length, and luck: How genes are prioritized by rare and common variant association studies. bioRxiv. 2024 Dec 16. Spence JP, Mostafavi H, Ota M, Milind N, Gjorgjieva T, Smith CJ, Simons YB, Sella G, Pritchard JK. PMID: 39935885; PMCID: PMC11812597.
      View in: PubMed   Mentions:
    30. Multimodal predictive modeling: Scalable imaging informed approaches to predict future brain health. J Neurosci Methods. 2025 02; 414:110322. Ajith M, Spence JS, Chapman SB, Calhoun VD. PMID: 39608579; PMCID: PMC11687617.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    31. Gene regulatory network structure informs the distribution of perturbation effects. bioRxiv. 2024 Oct 22. Aguirre M, Spence JP, Sella G, Pritchard JK. PMID: 39005431; PMCID: PMC11245109.
      View in: PubMed   Mentions:
    32. Estimation of demography and mutation rates from one million haploid genomes. bioRxiv. 2024 Sep 21. Schraiber JG, Spence JP, Edge MD. PMID: 39345369; PMCID: PMC11429810.
      View in: PubMed   Mentions:
    33. Diversity of ribosomes at the level of rRNA variation associated with human health and disease. Cell Genom. 2024 Sep 11; 4(9):100629. Rothschild D, Susanto TT, Sui X, Spence JP, Rangan R, Genuth NR, Sinnott-Armstrong N, Wang X, Pritchard JK, Barna M. PMID: 39111318; PMCID: PMC11480859.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    34. grenedalf: population genetic statistics for the next generation of pool sequencing. Bioinformatics. 2024 08 02; 40(8). Czech L, Spence JP, Expósito-Alonso M. PMID: 39185959; PMCID: PMC11357794.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    35. Investigating the Role of Neighborhood Socioeconomic Status and Germline Genetics on Prostate Cancer Risk. medRxiv. 2024 Aug 02. Judd J, Spence JP, Pritchard JK, Kachuri L, Witte JS. PMID: 39132496; PMCID: PMC11312637.
      View in: PubMed   Mentions:
    36. Haplotype Analysis Reveals Pleiotropic Disease Associations in the HLA Region. medRxiv. 2024 Jul 31. Smith CJ, Strausz S, FinnGen, Spence JP, Ollila HM, Pritchard JK. PMID: 39132491; PMCID: PMC11312630.
      View in: PubMed   Mentions:
    37. Bayesian estimation of gene constraint from an evolutionary model with gene features. Nat Genet. 2024 Aug; 56(8):1632-1643. Zeng T, Spence JP, Mostafavi H, Pritchard JK. PMID: 38977852.
      View in: PubMed   Mentions: 45     Fields:    Translation:Humans
    38. Greater physical fitness ( VO2max ) in healthy older adults associated with increased integrity of the locus coeruleus-noradrenergic system. Acta Physiol (Oxf). 2024 08; 240(8):e14191. Plini ERG, Melnychuk MC, Andrews R, Boyle R, Whelan R, Spence JS, Chapman SB, Robertson IH, Dockree PM. PMID: 38895950; PMCID: PMC11250687.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    39. Conditional frequency spectra as a tool for studying selection on complex traits in biobanks. bioRxiv. 2024 Jun 17. Patel RA, Weiß CL, Zhu H, Mostafavi H, Simons YB, Spence JP, Pritchard JK. PMID: 38948697; PMCID: PMC11212903.
      View in: PubMed   Mentions:
    40. Diversity of ribosomes at the level of rRNA variation associated with human health and disease. bioRxiv. 2024 Jun 07. Rothschild D, Susanto TT, Sui X, Spence JP, Rangan R, Genuth NR, Sinnott-Armstrong N, Wang X, Pritchard JK, Barna M. PMID: 36778251; PMCID: PMC9915487.
      View in: PubMed   Mentions:
    41. Multimodal Predictive Modeling: Scalable Imaging Informed Approaches to Predict Future Brain Health. bioRxiv. 2024 May 30. Ajith M, Spence JS, Chapman SB, Calhoun VD. PMID: 38854031; PMCID: PMC11160794.
      View in: PubMed   Mentions:
    42. Bayesian estimation of gene constraint from an evolutionary model with gene features. bioRxiv. 2024 Apr 10. Zeng T, Spence JP, Mostafavi H, Pritchard JK. PMID: 37292653; PMCID: PMC10245655.
      View in: PubMed   Mentions:
    43. A SIMPLE AND FLEXIBLE TEST OF SAMPLE EXCHANGEABILITY WITH APPLICATIONS TO STATISTICAL GENOMICS. Ann Appl Stat. 2024 Mar; 18(1):858-881. Aw AJ, Spence JP, Song YS. PMID: 38784669; PMCID: PMC11115382.
      View in: PubMed   Mentions: 2  
    44. Stable population structure in Europe since the Iron Age, despite high mobility. Elife. 2024 Jan 30; 13. Antonio ML, Weiß CL, Gao Z, Sawyer S, Oberreiter V, Moots HM, Spence JP, Cheronet O, Zagorc B, Praxmarer E, Özdogan KT, Demetz L, Gelabert P, Fernandes D, Lucci M, Alihodžic T, Amrani S, Avetisyan P, Baillif-Ducros C, Bedic Ž, Bertrand A, Bilic M, Bondioli L, Borówka P, Botte E, Burmaz J, Bužanic D, Candilio F, Cvetko M, De Angelis D, Drnic I, Elschek K, Fantar M, Gaspari A, Gasperetti G, Genchi F, Golubovic S, Hukelová Z, Jankauskas R, Vuckovic KJ, Jeremic G, Kaic I, Kazek K, Khachatryan H, Khudaverdyan A, Kirchengast S, Korac M, Kozlowski V, Krošláková M, Kušan Špalj D, La Pastina F, Laguardia M, Legrand S, Lelekovic T, Leskovar T, Lorkiewicz W, Los D, Silva AM, Masaryk R, Matijevic V, Cherifi YMS, Meyer N, Mikic I, Miladinovic-Radmilovic N, Miloševic Zakic B, Nacouzi L, Natuniewicz-Sekula M, Nava A, Neugebauer-Maresch C, Novácek J, Osterholtz A, Paige J, Paraman L, Pieri D, Pieta K, Pop-Lazic S, Ruttkay M, Sanader M, Soltysiak A, Sperduti A, Stankovic Pesterac T, Teschler-Nicola M, Teul I, Toncinic D, Trapp J, Vulovic D, Waliszewski T, Walter D, Živanovic M, Filah MEM, Cauševic-Bully M, Šlaus M, Boric D, Novak M, Coppa A, Pinhasi R, Pritchard JK. PMID: 38288729; PMCID: PMC10827293.
      View in: PubMed   Mentions: 45     Fields:    Translation:Humans
    45. Toward precision brain health: accurate prediction of a cognitive index trajectory using neuroimaging metrics. Cereb Cortex. 2024 01 14; 34(1). Spence JS, Turner MP, Rypma B, D'Esposito M, Chapman SB. PMID: 37968568.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    46. Scaling the discrete-time Wright-Fisher model to biobank-scale datasets. Genetics. 2023 11 01; 225(3). Spence JP, Zeng T, Mostafavi H, Pritchard JK. PMID: 37724741; PMCID: PMC10627256.
      View in: PubMed   Mentions: 15     Fields:    
    47. Systematic differences in discovery of genetic effects on gene expression and complex traits. Nat Genet. 2023 11; 55(11):1866-1875. Mostafavi H, Spence JP, Naqvi S, Pritchard JK. PMID: 37857933; PMCID: PMC12270542.
      View in: PubMed   Mentions: 182     Fields:    
    48. Greater physical fitness (Vo2Max) in healthy older adults associated with increased integrity of the Locus Coeruleus-Noradrenergic system. Res Sq. 2023 Sep 12. Plini ER, Melnychuk MC, Andrews R, Boyle R, Whelan R, Spence JS, Chapman SB, Robertson IH, Dockree PM. PMID: 36798156; PMCID: PMC9934752.
      View in: PubMed   Mentions:
    49. Exploring how brain health strategy training informs the future of work. Front Psychol. 2023; 14:1175652. Zientz J, Spence JS, Chung SSE, Nanda U, Chapman SB. PMID: 37771803; PMCID: PMC10524270.
      View in: PubMed   Mentions: 3  
    50. A genetic history of continuity and mobility in the Iron Age central Mediterranean. Nat Ecol Evol. 2023 09; 7(9):1515-1524. Moots HM, Antonio M, Sawyer S, Spence JP, Oberreiter V, Weiß CL, Lucci M, Cherifi YMS, La Pastina F, Genchi F, Praxmeier E, Zagorc B, Cheronet O, Özdogan KT, Demetz L, Amrani S, Candilio F, De Angelis D, Gasperetti G, Fernandes D, Gao Z, Fantar M, Coppa A, Pritchard JK, Pinhasi R. PMID: 37592021.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    51. Expanding the stdpopsim species catalog, and lessons learned for realistic genome simulations. Elife. 2023 06 21; 12. Lauterbur ME, Cavassim MIA, Gladstein AL, Gower G, Pope NS, Tsambos G, Adrion J, Belsare S, Biddanda A, Caudill V, Cury J, Echevarria I, Haller BC, Hasan AR, Huang X, Iasi LNM, Noskova E, Obsteter J, Pavinato VAC, Pearson A, Peede D, Perez MF, Rodrigues MF, Smith CCR, Spence JP, Teterina A, Tittes S, Unneberg P, Vazquez JM, Waples RK, Wohns AW, Wong Y, Baumdicker F, Cartwright RA, Gorjanc G, Gutenkunst RN, Kelleher J, Kern AD, Ragsdale AP, Ralph PL, Schrider DR, Gronau I. PMID: 37342968; PMCID: PMC10328510.
      View in: PubMed   Mentions: 31     Fields:    
    52. Bayesian estimation of gene constraint from an evolutionary model with gene features. Res Sq. 2023 Jun 13. Zeng T, Spence JP, Mostafavi H, Pritchard JK. PMID: 37398424; PMCID: PMC10312940.
      View in: PubMed   Mentions:
    53. Scaling the Discrete-time Wright Fisher model to biobank-scale datasets. bioRxiv. 2023 May 22. Spence JP, Zeng T, Mostafavi H, Pritchard JK. PMID: 37293115; PMCID: PMC10245735.
      View in: PubMed   Mentions:
    54. Whole-genome sequencing reveals a complex African population demographic history and signatures of local adaptation. Cell. 2023 03 02; 186(5):923-939.e14. Fan S, Spence JP, Feng Y, Hansen MEB, Terhorst J, Beltrame MH, Ranciaro A, Hirbo J, Beggs W, Thomas N, Nyambo T, Mpoloka SW, Mokone GG, Njamnshi A, Folkunang C, Meskel DW, Belay G, Song YS, Tishkoff SA. PMID: 36868214; PMCID: PMC10568978.
      View in: PubMed   Mentions: 50     Fields:    Translation:Humans
    55. Effects of online brain training on self-reported mental health symptoms for generally healthy adults during the Covid-19 pandemic. Brain Behav. 2023 01; 13(1):e2853. Laane SA, Cook LG, Spence JS, Harris MN, Chapman SB. PMID: 36542528; PMCID: PMC9847605.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansPHPublic Health
    56. Altered linear coupling between stimulus-evoked blood flow and oxygen metabolism in the aging human brain. Cereb Cortex. 2022 12 15; 33(1):135-151. Turner MP, Zhao Y, Abdelkarim D, Liu P, Spence JS, Hutchison JL, Sivakolundu DK, Thomas BP, Hubbard NA, Xu C, Taneja K, Lu H, Rypma B. PMID: 35388407; PMCID: PMC9758587.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    57. Genetic diversity loss in the Anthropocene. Science. 2022 09 23; 377(6613):1431-1435. Exposito-Alonso M, Booker TR, Czech L, Gillespie L, Hateley S, Kyriazis CC, Lang PLM, Leventhal L, Nogues-Bravo D, Pagowski V, Ruffley M, Spence JP, Toro Arana SE, Weiß CL, Zess E. PMID: 36137047.
      View in: PubMed   Mentions: 76     Fields:    Translation:Animals
    58. Genetic interactions drive heterogeneity in causal variant effect sizes for gene expression and complex traits. Am J Hum Genet. 2022 07 07; 109(7):1286-1297. Patel RA, Musharoff SA, Spence JP, Pimentel H, Tcheandjieu C, Mostafavi H, Sinnott-Armstrong N, Clarke SL, Smith CJ, V.A. Million Veteran Program, Durda PP, Taylor KD, Tracy R, Liu Y, Johnson WC, Aguet F, Ardlie KG, Gabriel S, Smith J, Nickerson DA, Rich SS, Rotter JI, Tsao PS, Assimes TL, Pritchard JK. PMID: 35716666; PMCID: PMC9300878.
      View in: PubMed   Mentions: 48     Fields:    Translation:Humans
    59. Snoring Remediation with Oral Appliance Therapy Potentially Reverses Cognitive Impairment: An Intervention Controlled Pilot Study. Geriatrics (Basel). 2021 Nov 01; 6(4). Schramm P, Das N, Schneiderman E, German Z, Hui J, Wilson D, Spence JS, Moura P, Chapman SB. PMID: 34842718; PMCID: PMC8628661.
      View in: PubMed   Mentions: 3  
    60. EEG theta and alpha oscillations in early versus late mild cognitive impairment during a semantic Go/NoGo task. Behav Brain Res. 2022 01 07; 416:113539. Lydon EA, Nguyen LT, Shende SA, Chiang HS, Spence JS, Mudar RA. PMID: 34416304.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    61. Shared heritability of human face and brain shape. Nat Genet. 2021 06; 53(6):830-839. Naqvi S, Sleyp Y, Hoskens H, Indencleef K, Spence JP, Bruffaerts R, Radwan A, Eller RJ, Richmond S, Shriver MD, Shaffer JR, Weinberg SM, Walsh S, Thompson J, Pritchard JK, Sunaert S, Peeters H, Wysocka J, Claes P. PMID: 33821002; PMCID: PMC8232039.
      View in: PubMed   Mentions: 60     Fields:    Translation:Humans
    62. Efficacy of Cognitive Training When Translated From the Laboratory to the Real World. Mil Med. 2021 01 25; 186(Suppl 1):176-183. Young LR, Zientz JE, Spence JS, Krawczyk DC, Chapman SB. PMID: 33499529; PMCID: PMC7980485.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    63. Identification of selection and inhibition components in a Go/NoGo task from EEG spectra using a machine learning classifier. Brain Behav. 2020 12; 10(12):e01902. DeLaRosa BL, Spence JS, Motes MA, To W, Vanneste S, Kraut MA, Hart J. PMID: 33078586; PMCID: PMC7749513.
      View in: PubMed   Mentions: 9     Fields:    
    64. Relationship of Parieto-Occipital Brain Energy Phosphate Metabolism and Cognition Using 31P MRS at 7-Tesla in Amnestic Mild Cognitive Impairment. Front Aging Neurosci. 2020; 12:222. Das N, Ren J, Spence JS, Rackley A, Chapman SB. PMID: 33005142; PMCID: PMC7483543.
      View in: PubMed   Mentions: 14  
    65. Multimodal feature binding in object memory retrieval using event-related potentials: Implications for models of semantic memory. Int J Psychophysiol. 2020 07; 153:116-126. Chiang HS, Spence JS, Eroh JT, Maguire MJ, Kraut MA, Hart J. PMID: 32389620.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    66. Altered task-induced cerebral blood flow and oxygen metabolism underlies motor impairment in multiple sclerosis. J Cereb Blood Flow Metab. 2021 01; 41(1):182-193. West KL, Sivakolundu DK, Zuppichini MD, Turner MP, Spence JS, Lu H, Okuda DT, Rypma B. PMID: 32126873; PMCID: PMC7747162.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    67. Inference and analysis of population-specific fine-scale recombination maps across 26 diverse human populations. Sci Adv. 2019 10; 5(10):eaaw9206. Spence JP, Song YS. PMID: 31681842; PMCID: PMC6810367.
      View in: PubMed   Mentions: 101     Fields:    Translation:HumansCells
    68. Neurophysiology of threat processing bias in combat-related post-traumatic stress disorder. Hum Brain Mapp. 2020 01; 41(1):218-229. DeLaRosa BL, Spence JS, Didehbani N, Tillman GD, Motes MA, Bass C, Kraut MA, Hart J. PMID: 31584243; PMCID: PMC7268056.
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    69. High-Definition Transcranial Direct Current Stimulation to Improve Verbal Retrieval Deficits in Chronic Traumatic Brain Injury. J Neurotrauma. 2020 01 01; 37(1):170-177. Motes MA, Spence JS, Yeatman K, Jones PM, Lutrell M, O'Hair R, Shakal S, DeLaRosa BL, To W, Vanneste S, Kraut MA, Hart J. PMID: 31354040.
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    70. Inference of complex population histories using whole-genome sequences from multiple populations. Proc Natl Acad Sci U S A. 2019 08 20; 116(34):17115-17120. Steinrücken M, Kamm J, Spence JP, Song YS. PMID: 31387977; PMCID: PMC6708337.
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    71. Reduced arterial compliance along the cerebrovascular tree predicts cognitive slowing in multiple sclerosis: Evidence for a neurovascular uncoupling hypothesis. Mult Scler. 2020 10; 26(12):1486-1496. Sivakolundu DK, West KL, Maruthy GB, Zuppichini M, Turner MP, Abdelkarim D, Zhao Y, Nguyen D, Spence JS, Lu H, Okuda DT, Rypma B. PMID: 31373536.
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    72. Opioid Utilization and Perception of Pain Control in Hospitalized Patients: A Cross-Sectional Study of 11 Sites in 8 Countries. J Hosp Med. 2019 12 01; 14(12):737-745. Burden M, Keniston A, Wallace MA, Busse JW, Casademont J, Chadaga SR, Chandrasekaran S, Cicardi M, Cunningham JM, Filella D, Hoody D, Hilden D, Hsieh MJ, Lee YS, Melley DD, Munoa A, Perego F, Shu CC, Sohn CH, Spence J, Thurman L, Towns CR, You J, Zocchi L, Albert RK. PMID: 31339840.
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    73. Cognitive Training and Transcranial Direct Current Stimulation in Mild Cognitive Impairment: A Randomized Pilot Trial. Front Neurosci. 2019; 13:307. Das N, Spence JS, Aslan S, Vanneste S, Mudar R, Rackley A, Quiceno M, Chapman SB. PMID: 31031581; PMCID: PMC6473050.
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    74. BOLD hemodynamic response function changes significantly with healthy aging. Neuroimage. 2019 03; 188:198-207. West KL, Zuppichini MD, Turner MP, Sivakolundu DK, Zhao Y, Abdelkarim D, Spence JS, Rypma B. PMID: 30529628; PMCID: PMC6450381.
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    75. A Likelihood-Free Inference Framework for Population Genetic Data using Exchangeable Neural Networks. Adv Neural Inf Process Syst. 2018 Dec; 31:8594-8605. Chan J, Perrone V, Spence JP, Jenkins PA, Mathieson S, Song YS. PMID: 33244210; PMCID: PMC7687905.
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    76. Gulf War illness associated with abnormal auditory P1 event-related potential: Evidence of impaired cholinergic processing replicated in a national sample. Psychiatry Res Neuroimaging. 2019 01 30; 283:7-15. Tillman GD, Spence JS, Briggs RW, Haley RW, Hart J, Kraut MA. PMID: 30453127.
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    77. Early human dispersals within the Americas. Science. 2018 12 07; 362(6419). Moreno-Mayar JV, Vinner L, de Barros Damgaard P, de la Fuente C, Chan J, Spence JP, Allentoft ME, Vimala T, Racimo F, Pinotti T, Rasmussen S, Margaryan A, Iraeta Orbegozo M, Mylopotamitaki D, Wooller M, Bataille C, Becerra-Valdivia L, Chivall D, Comeskey D, Devièse T, Grayson DK, George L, Harry H, Alexandersen V, Primeau C, Erlandson J, Rodrigues-Carvalho C, Reis S, Bastos MQR, Cybulski J, Vullo C, Morello F, Vilar M, Wells S, Gregersen K, Hansen KL, Lynnerup N, Mirazón Lahr M, Kjær K, Strauss A, Alfonso-Durruty M, Salas A, Schroeder H, Higham T, Malhi RS, Rasic JT, Souza L, Santos FR, Malaspinas AS, Sikora M, Nielsen R, Song YS, Meltzer DJ, Willerslev E. PMID: 30409807.
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    78. Inference of population history using coalescent HMMs: review and outlook. Curr Opin Genet Dev. 2018 12; 53:70-76. Spence JP, Steinrücken M, Terhorst J, Song YS. PMID: 30056275; PMCID: PMC6296859.
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    79. Influential Cognitive Processes on Framing Biases in Aging. Front Psychol. 2018; 9:661. Perez AM, Spence JS, Kiel LD, Venza EE, Chapman SB. PMID: 29867641; PMCID: PMC5958213.
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    80. Model-based detection and analysis of introgressed Neanderthal ancestry in modern humans. Mol Ecol. 2018 10; 27(19):3873-3888. Steinrücken M, Spence JP, Kamm JA, Wieczorek E, Song YS. PMID: 29603507; PMCID: PMC6165692.
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    81. Preserved canonicality of the BOLD hemodynamic response reflects healthy cognition: Insights into the healthy brain through the window of Multiple Sclerosis. Neuroimage. 2019 04 15; 190:46-55. Turner MP, Hubbard NA, Sivakolundu DK, Himes LM, Hutchison JL, Hart J, Spence JS, Frohman EM, Frohman TC, Okuda DT, Rypma B. PMID: 29454932; PMCID: PMC6093806.
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    82. Age effects on event-related potentials in individuals with amnestic Mild Cognitive Impairment during semantic categorization Go/NoGo tasks. Neurosci Lett. 2018 03 23; 670:19-21. Chiang HS, Spence JS, Kraut MA, Mudar RA. PMID: 29357294.
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    83. Repetitive TMS to augment cognitive processing therapy in combat veterans of recent conflicts with PTSD: A randomized clinical trial. J Affect Disord. 2018 Mar 15; 229:506-514. Kozel FA, Motes MA, Didehbani N, DeLaRosa B, Bass C, Schraufnagel CD, Jones P, Morgan CR, Spence JS, Kraut MA, Hart J. PMID: 29351885.
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    84. Higher-order cognitive training effects on processing speed-related neural activity: a randomized trial. Neurobiol Aging. 2018 02; 62:72-81. Motes MA, Yezhuvath US, Aslan S, Spence JS, Rypma B, Chapman SB. PMID: 29121545; PMCID: PMC5743765.
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    85. Enhancing Innovation and Underlying Neural Mechanisms Via Cognitive Training in Healthy Older Adults. Front Aging Neurosci. 2017; 9:314. Chapman SB, Spence JS, Aslan S, Keebler MW. PMID: 29062276; PMCID: PMC5640779.
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    86. Calibrated imaging reveals altered grey matter metabolism related to white matter microstructure and symptom severity in multiple sclerosis. Hum Brain Mapp. 2017 11; 38(11):5375-5390. Hubbard NA, Turner MP, Ouyang M, Himes L, Thomas BP, Hutchison JL, Faghihahmadabadi S, Davis SL, Strain JF, Spence J, Krawczyk DC, Huang H, Lu H, Hart J, Frohman TC, Frohman EM, Okuda DT, Rypma B. PMID: 28815879; PMCID: PMC5877313.
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    87. Enhancing Executive Function and Neural Health in Bipolar Disorder through Reasoning Training. Front Psychol. 2016; 7:1676. Venza EE, Chapman SB, Aslan S, Zientz JE, Tyler DL, Spence JS. PMID: 27847486; PMCID: PMC5088411.
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    88. Successful classification of cocaine dependence using brain imaging: a generalizable machine learning approach. BMC Bioinformatics. 2016 Oct 06; 17(Suppl 13):357. Mete M, Sakoglu U, Spence JS, Devous MD, Harris TS, Adinoff B. PMID: 27766943; PMCID: PMC5073995.
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    89. The Simons Genome Diversity Project: 300 genomes from 142 diverse populations. Nature. 2016 Oct 13; 538(7624):201-206. Mallick S, Li H, Lipson M, Mathieson I, Gymrek M, Racimo F, Zhao M, Chennagiri N, Nordenfelt S, Tandon A, Skoglund P, Lazaridis I, Sankararaman S, Fu Q, Rohland N, Renaud G, Erlich Y, Willems T, Gallo C, Spence JP, Song YS, Poletti G, Balloux F, van Driem G, de Knijff P, Romero IG, Jha AR, Behar DM, Bravi CM, Capelli C, Hervig T, Moreno-Estrada A, Posukh OL, Balanovska E, Balanovsky O, Karachanak-Yankova S, Sahakyan H, Toncheva D, Yepiskoposyan L, Tyler-Smith C, Xue Y, Abdullah MS, Ruiz-Linares A, Beall CM, Di Rienzo A, Jeong C, Starikovskaya EB, Metspalu E, Parik J, Villems R, Henn BM, Hodoglugil U, Mahley R, Sajantila A, Stamatoyannopoulos G, Wee JT, Khusainova R, Khusnutdinova E, Litvinov S, Ayodo G, Comas D, Hammer MF, Kivisild T, Klitz W, Winkler CA, Labuda D, Bamshad M, Jorde LB, Tishkoff SA, Watkins WS, Metspalu M, Dryomov S, Sukernik R, Singh L, Thangaraj K, Pääbo S, Kelso J, Patterson N, Reich D. PMID: 27654912; PMCID: PMC5161557.
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    90. Distinct Brain and Behavioral Benefits from Cognitive vs. Physical Training: A Randomized Trial in Aging Adults. Front Hum Neurosci. 2016; 10:338. Chapman SB, Aslan S, Spence JS, Keebler MW, DeFina LF, Didehbani N, Perez AM, Lu H, D'Esposito M. PMID: 27462210; PMCID: PMC4939293.
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    92. Two-Locus Likelihoods Under Variable Population Size and Fine-Scale Recombination Rate Estimation. Genetics. 2016 07; 203(3):1381-99. Kamm JA, Spence JP, Chan J, Song YS. PMID: 27182948; PMCID: PMC4937484.
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    93. Enhancing latent cognitive capacity in mild cognitive impairment with gist reasoning training: a pilot study. Int J Geriatr Psychiatry. 2017 05; 32(5):548-555. Mudar RA, Chapman SB, Rackley A, Eroh J, Chiang HS, Perez A, Venza E, Spence JS. PMID: 27112124; PMCID: PMC5412912.
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    94. The Site Frequency Spectrum for General Coalescents. Genetics. 2016 Apr; 202(4):1549-61. Spence JP, Kamm JA, Song YS. PMID: 26883445; PMCID: PMC4827730.
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    95. The Effects of Amnestic Mild Cognitive Impairment on Go/NoGo Semantic Categorization Task Performance and Event-Related Potentials. J Alzheimers Dis. 2016; 50(2):577-90. Mudar RA, Chiang HS, Eroh J, Nguyen LT, Maguire MJ, Spence JS, Kung F, Kraut MA, Hart J. PMID: 26836634.
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    96. Factors Impacting Functional Status in Veterans of Recent Conflicts With PTSD. J Neuropsychiatry Clin Neurosci. 2016; 28(2):112-7. Kozel FA, Didehbani N, DeLaRosa B, Bass C, Schraufnagel CD, Morgan CR, Jones P, Spence JS, Hart J. PMID: 26670785.
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    97. Imaging Correlates of Memory and Concussion History in Retired National Football League Athletes. JAMA Neurol. 2015 Jul; 72(7):773-80. Strain JF, Womack KB, Didehbani N, Spence JS, Conover H, Hart J, Kraut MA, Cullum CM. PMID: 25985094; PMCID: PMC6761828.
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    98. Word-finding impairment in veterans of the 1991 Persian Gulf War. Brain Cogn. 2015 Aug; 98:65-73. Moffett K, Crosson B, Spence JS, Case K, Levy I, Gopinath K, Shah P, Goyal A, Fang Y, Briggs RW, Hart J, Moore A, Haley RW. PMID: 26114921.
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    99. Effects of age on cognitive control during semantic categorization. Behav Brain Res. 2015; 287:285-93. Mudar RA, Chiang HS, Maguire MJ, Spence JS, Eroh J, Kraut MA, Hart J. PMID: 25823764; PMCID: PMC4447127.
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    100. Altered Neural Activity during Semantic Object Memory Retrieval in Amnestic Mild Cognitive Impairment as Measured by Event-Related Potentials. J Alzheimers Dis. 2015; 46(3):703-17. Chiang HS, Mudar RA, Pudhiyidath A, Spence JS, Womack KB, Cullum CM, Tanner JA, Eroh J, Kraut MA, Hart J. PMID: 25835419; PMCID: PMC6759586.
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    101. Enhancing inferential abilities in adolescence: new hope for students in poverty. Front Hum Neurosci. 2014; 8:924. Gamino JF, Motes MM, Riddle R, Lyon GR, Spence JS, Chapman SB. PMID: 25505393; PMCID: PMC4243561.
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    102. Long-term effects of marijuana use on the brain. Proc Natl Acad Sci U S A. 2014 Nov 25; 111(47):16913-8. Filbey FM, Aslan S, Calhoun VD, Spence JS, Damaraju E, Caprihan A, Segall J. PMID: 25385625; PMCID: PMC4250161.
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    103. Electrophysiological spatiotemporal dynamics during implicit visual threat processing. Brain Cogn. 2014 Nov; 91:54-61. DeLaRosa BL, Spence JS, Shakal SK, Motes MA, Calley CS, Calley VI, Hart J, Kraut MA. PMID: 25222294.
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    104. Age-related changes in feature-based object memory retrieval as measured by event-related potentials. Biol Psychol. 2014 Jul; 100:106-14. Chiang HS, Mudar RA, Spence JS, Pudhiyidath A, Eroh J, DeLaRosa B, Kraut MA, Hart J. PMID: 24911552; PMCID: PMC4119884.
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    105. Shorter term aerobic exercise improves brain, cognition, and cardiovascular fitness in aging. Front Aging Neurosci. 2013; 5:75. Chapman SB, Aslan S, Spence JS, Defina LF, Keebler MW, Didehbani N, Lu H. PMID: 24282403; PMCID: PMC3825180.
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    106. Neural mechanisms of brain plasticity with complex cognitive training in healthy seniors. Cereb Cortex. 2015 Feb; 25(2):396-405. Chapman SB, Aslan S, Spence JS, Hart JJ, Bartz EK, Didehbani N, Keebler MW, Gardner CM, Strain JF, DeFina LF, Lu H. PMID: 23985135; PMCID: PMC4351428.
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    107. Threat as a feature in visual semantic object memory. Hum Brain Mapp. 2013 Aug; 34(8):1946-55. Calley CS, Motes MA, Chiang HS, Buhl V, Spence JS, Abdi H, Anand R, Maguire M, Estevez L, Briggs R, Freeman T, Kraut MA, Hart J. PMID: 22451240; PMCID: PMC6870184.
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    108. Removing an intersubject variance component in a general linear model improves multiway factoring of event-related spectral perturbations in group EEG studies. Hum Brain Mapp. 2013 Mar; 34(3):651-64. Spence JS, Brier MR, Hart J, Ferree TC. PMID: 22102426; PMCID: PMC6869945.
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    109. Hippocampal dysfunction in Gulf War veterans: investigation with ASL perfusion MR imaging and physostigmine challenge. Radiology. 2011 Oct; 261(1):218-25. Li X, Spence JS, Buhner DM, Hart J, Cullum CM, Biggs MM, Hester AL, Odegard TN, Carmack PS, Briggs RW, Haley RW. PMID: 21914840; PMCID: PMC3176422.
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    110. Abnormal brain response to cholinergic challenge in chronic encephalopathy from the 1991 Gulf War. Psychiatry Res. 2009 Mar 31; 171(3):207-20. Haley RW, Spence JS, Carmack PS, Gunst RF, Schucany WR, Petty F, Devous MD, Bonte FJ, Trivedi MH. PMID: 19230625.
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    111. Using a white matter reference to remove the dependency of global signal on experimental conditions in SPECT analyses. Neuroimage. 2006 Aug 01; 32(1):49-53. Spence JS, Carmack PS, Gunst RF, Schucany WR, Woodward WA, Haley RW. PMID: 16651010.
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