-
Molecular mechanisms of drug action: an emerging view. Annu Rev Biophys. 2013; 42:143-67.
Sonner JM, Cantor RS. PMID: 23451895.
View in:
PubMed Mentions:
24 Fields:
Translation:
HumansAnimals
-
3-Hydroxybutyric acid interacts with lipid monolayers at concentrations that impair consciousness. Langmuir. 2013 Feb 12; 29(6):1948-55.
Hsu TT, Leiske DL, Rosenfeld L, Sonner JM, Fuller GG. PMID: 23339286.
View in:
PubMed Mentions:
3 Fields:
Translation:
Cells
-
Gamma-aminobutyric acid type A receptor β3 subunit forebrain-specific knockout mice are resistant to the amnestic effect of isoflurane. Anesth Analg. 2011 Sep; 113(3):500-4.
Rau V, Oh I, Liao M, Bodarky C, Fanselow MS, Homanics GE, Sonner JM, Eger EI. PMID: 21813630; PMCID: PMC4003562.
View in:
PubMed Mentions:
16 Fields:
Translation:
Animals
-
Functional prokaryotic-eukaryotic chimera from the pentameric ligand-gated ion channel family. Proc Natl Acad Sci U S A. 2011 Jul 19; 108(29):12143-8.
Duret G, Van Renterghem C, Weng Y, Prevost M, Moraga-Cid G, Huon C, Sonner JM, Corringer PJ. PMID: 21730130; PMCID: PMC3141993.
View in:
PubMed Mentions:
49 Fields:
Translation:
AnimalsCells
-
X-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel. Nature. 2011 Jan 20; 469(7330):428-31.
Nury H, Van Renterghem C, Weng Y, Tran A, Baaden M, Dufresne V, Changeux JP, Sonner JM, Delarue M, Corringer PJ. PMID: 21248852.
View in:
PubMed Mentions:
224 Fields:
Translation:
Cells
-
Conserved role of unc-79 in ethanol responses in lightweight mutant mice. PLoS Genet. 2010 Aug 12; 6(8).
Speca DJ, Chihara D, Ashique AM, Bowers MS, Pierce-Shimomura JT, Lee J, Rabbee N, Speed TP, Gularte RJ, Chitwood J, Medrano JF, Liao M, Sonner JM, Eger EI, Peterson AS, McIntire SL. PMID: 20714347; PMCID: PMC2920847.
View in:
PubMed Mentions:
31 Fields:
Translation:
Animals
-
Gamma-aminobutyric acid type A receptor alpha 4 subunit knockout mice are resistant to the amnestic effect of isoflurane. Anesth Analg. 2009 Dec; 109(6):1816-22.
Rau V, Iyer SV, Oh I, Chandra D, Harrison N, Eger EI, Fanselow MS, Homanics GE, Sonner JM. PMID: 19923508; PMCID: PMC2895314.
View in:
PubMed Mentions:
20 Fields:
Translation:
Animals
-
Anesthetic sensitivity of the Gloeobacter violaceus proton-gated ion channel. Anesth Analg. 2010 Jan 01; 110(1):59-63.
Weng Y, Yang L, Corringer PJ, Sonner JM. PMID: 19933531; PMCID: PMC2897236.
View in:
PubMed Mentions:
54 Fields:
Translation:
AnimalsCells
-
Isovaleric, methylmalonic, and propionic acid decrease anesthetic EC50 in tadpoles, modulate glycine receptor function, and interact with the lipid 1,2-dipalmitoyl-Sn-glycero-3-phosphocholine. Anesth Analg. 2009 May; 108(5):1538-45.
Weng Y, Hsu TT, Zhao J, Nishimura S, Fuller GG, Sonner JM. PMID: 19372333; PMCID: PMC2897242.
View in:
PubMed Mentions:
5 Fields:
Translation:
AnimalsCells
-
Tolerance to isoflurane does not occur in developing Xenopus laevis tadpoles. Anesth Analg. 2009 Jan; 108(1):176-80.
Milutinovic PS, Zhao J, Sonner JM. PMID: 19095846; PMCID: PMC2627504.
View in:
PubMed Mentions:
3 Fields:
Translation:
Animals
-
A hypothesis on the origin and evolution of the response to inhaled anesthetics. Anesth Analg. 2008 Sep; 107(3):849-54.
Sonner JM. PMID: 18713893; PMCID: PMC2627509.
View in:
PubMed Mentions:
15 Fields:
Translation:
HumansAnimalsCells
-
Is a new paradigm needed to explain how inhaled anesthetics produce immobility? Anesth Analg. 2008 Sep; 107(3):832-48.
Eger EI, Raines DE, Shafer SL, Hemmings HC, Sonner JM. PMID: 18713892; PMCID: PMC2653203.
View in:
PubMed Mentions:
39 Fields:
Translation:
HumansAnimals
-
Anesthetic-like modulation of receptor function by surfactants: a test of the interfacial theory of anesthesia. Anesth Analg. 2008 Sep; 107(3):868-74.
Yang L, Sonner JM. PMID: 18713898; PMCID: PMC2668573.
View in:
PubMed Mentions:
7 Fields:
Translation:
AnimalsCells
-
Inhaled anesthetics do not combine to produce synergistic effects regarding minimum alveolar anesthetic concentration in rats. Anesth Analg. 2008 Aug; 107(2):479-85.
Eger EI, Tang M, Liao M, Laster MJ, Solt K, Flood P, Jenkins A, Raines D, Hendrickx JF, Shafer SL, Yasumasa T, Sonner JM. PMID: 18633026.
View in:
PubMed Mentions:
15 Fields:
Translation:
Animals
-
Is synergy the rule? A review of anesthetic interactions producing hypnosis and immobility. Anesth Analg. 2008 Aug; 107(2):494-506.
Hendrickx JF, Eger EI, Sonner JM, Shafer SL. PMID: 18633028.
View in:
PubMed Mentions:
75 Fields:
Translation:
HumansAnimals
-
Additivity versus synergy: a theoretical analysis of implications for anesthetic mechanisms. Anesth Analg. 2008 Aug; 107(2):507-24.
Shafer SL, Hendrickx JF, Flood P, Sonner J, Eger EI. PMID: 18633029.
View in:
PubMed Mentions:
19 Fields:
Translation:
Cells
-
Knockout of the gene encoding the K(2P) channel KCNK7 does not alter volatile anesthetic sensitivity. Behav Brain Res. 2008 Nov 21; 193(2):192-6.
Yost CS, Oh I, Eger EI, Sonner JM. PMID: 18572259; PMCID: PMC2669440.
View in:
PubMed Mentions:
13 Fields:
Translation:
AnimalsCells
-
The anesthetic-like effects of diverse compounds on wild-type and mutant gamma-aminobutyric acid type A and glycine receptors. Anesth Analg. 2008 Mar; 106(3):838-45, table of contents.
Yang L, Sonner JM. PMID: 18292428.
View in:
PubMed Mentions:
2 Fields:
Translation:
HumansAnimalsCells
-
Intrathecal glycine significantly decreases the minimum alveolar concentration of isoflurane in rats. Chin Med Sci J. 2008 Mar; 23(1):16-8.
Zhao J, Zhang Y, Eger EI, Sonner J. PMID: 18437904.
View in:
PubMed Mentions:
1 Fields:
Translation:
Animals
-
Anesthetic properties of the ketone bodies beta-hydroxybutyric acid and acetone. Anesth Analg. 2007 Sep; 105(3):673-9.
Yang L, Zhao J, Milutinovic PS, Brosnan RJ, Eger EI, Sonner JM. PMID: 17717222.
View in:
PubMed Mentions:
23 Fields:
Translation:
HumansAnimalsCells
-
Alterations in spinal, but not cerebral, cerebrospinal fluid Na+ concentrations affect the isoflurane minimum alveolar concentration in rats. Anesth Analg. 2007 Sep; 105(3):661-5.
Laster MJ, Zhang Y, Eger EI, Shnayderman D, Sonner JM. PMID: 17717220.
View in:
PubMed Mentions:
4 Fields:
Translation:
Animals
-
The plasticizer di(2-ethylhexyl) phthalate modulates gamma-aminobutyric acid type A and glycine receptor function. Anesth Analg. 2007 Aug; 105(2):393-6.
Yang L, Milutinovic PS, Brosnan RJ, Eger EI, Sonner JM. PMID: 17646496.
View in:
PubMed Mentions:
10 Fields:
Translation:
Animals
-
Mouse chromosome 7 harbors a quantitative trait locus for isoflurane minimum alveolar concentration. Anesth Analg. 2007 Aug; 105(2):381-5.
Cascio M, Xing Y, Gong D, Popovich J, Eger EI, Sen S, Peltz G, Sonner JM. PMID: 17646494.
View in:
PubMed Mentions:
6 Fields:
Translation:
AnimalsCells
-
Anesthetic-like modulation of a gamma-aminobutyric acid type A, strychnine-sensitive glycine, and N-methyl-d-aspartate receptors by coreleased neurotransmitters. Anesth Analg. 2007 Aug; 105(2):386-92.
Milutinovic PS, Yang L, Cantor RS, Eger EI, Sonner JM. PMID: 17646495.
View in:
PubMed Mentions:
12 Fields:
Translation:
HumansAnimals
-
Ethnicity can affect anesthetic requirement. Anesthesiology. 2007 Jul; 107(1):4-5.
Sonner JM. PMID: 17585206.
View in:
PubMed Mentions:
3 Fields:
Translation:
HumansAnimals
-
Anesthetic properties of carbon dioxide in the rat. Anesth Analg. 2007 Jul; 105(1):103-6.
Brosnan RJ, Eger EI, Laster MJ, Sonner JM. PMID: 17578964.
View in:
PubMed Mentions:
15 Fields:
Translation:
Animals
-
Ammonia has anesthetic properties. Anesth Analg. 2007 Jun; 104(6):1430-3, table of contents.
Brosnan RJ, Yang L, Milutinovic PS, Zhao J, Laster MJ, Eger EI, Sonner JM. PMID: 17513636.
View in:
PubMed Mentions:
10 Fields:
Translation:
AnimalsCells
-
Lidocaine, MK-801, and MAC. Anesth Analg. 2007 May; 104(5):1098-102, tables of contents.
Zhang Y, Laster MJ, Eger EI, Sharma M, Sonner JM. PMID: 17456658.
View in:
PubMed Mentions:
10 Fields:
Translation:
Animals
-
Blockade of acetylcholine receptors does not change the dose of etomidate required to produce immobility in rats. Anesth Analg. 2007 Apr; 104(4):850-2.
Zhang Y, Laster MJ, Eger EI, Sharma M, Sonner JM. PMID: 17377093.
View in:
PubMed Mentions:
4 Fields:
Translation:
Animals
-
Determination of the EC50 amnesic concentration of etomidate and its diffusion profile in brain tissue: implications for in vitro studies. Anesthesiology. 2007 Jan; 106(1):114-23.
Benkwitz C, Liao M, Laster MJ, Sonner JM, Eger EI, Pearce RA. PMID: 17197853.
View in:
PubMed Mentions:
38 Fields:
Translation:
AnimalsCells
-
Effect of isoflurane and other potent inhaled anesthetics on minimum alveolar concentration, learning, and the righting reflex in mice engineered to express alpha1 gamma-aminobutyric acid type A receptors unresponsive to isoflurane. Anesthesiology. 2007 Jan; 106(1):107-13.
Sonner JM, Werner DF, Elsen FP, Xing Y, Liao M, Harris RA, Harrison NL, Fanselow MS, Eger EI, Homanics GE. PMID: 17197852.
View in:
PubMed Mentions:
32 Fields:
Translation:
Animals
-
Do dopamine receptors mediate part of MAC? Anesth Analg. 2006 Nov; 103(5):1177-81.
Tanifuji Y, Zhang Y, Liao M, Eger EI, Laster MJ, Sonner JM. PMID: 17056951.
View in:
PubMed Mentions:
2 Fields:
Translation:
Animals
-
Chirality in anesthesia II: stereoselective modulation of ion channel function by secondary alcohol enantiomers. Anesth Analg. 2006 Jul; 103(1):86-91, table of contents.
Brosnan R, Gong D, Cotten J, Keshavaprasad B, Yost CS, Eger EI, Sonner JM. PMID: 16790632.
View in:
PubMed Mentions:
12 Fields:
Translation:
AnimalsCells
-
Chirality in anesthesia I: minimum alveolar concentration of secondary alcohol enantiomers. Anesth Analg. 2006 Jul; 103(1):81-4, table of contents.
Won A, Oh I, Laster MJ, Popovich J, Eger EI, Sonner JM. PMID: 16790631.
View in:
PubMed Mentions:
5 Fields:
Translation:
AnimalsCells
-
Naloxone does not increase the minimum alveolar anesthetic concentration of sevoflurane in mice. Anesth Analg. 2006 May; 102(5):1452-5.
Liao M, Laster MJ, Eger EI, Tang M, Sonner JM. PMID: 16632825.
View in:
PubMed Mentions:
12 Fields:
Translation:
Animals
-
The minimum alveolar anesthetic concentration of 2-, 3-, and 4-alcohols and ketones in rats: relevance to anesthetic mechanisms. Anesth Analg. 2006 May; 102(5):1419-26.
Won A, Oh I, Liao M, Sonner JM, Harris RA, Laster MJ, Brosnan R, Trudell JR, Eger EI. PMID: 16632820.
View in:
PubMed Mentions:
1 Fields:
Translation:
Animals
-
Do N-methyl-D-aspartate receptors mediate the capacity of inhaled anesthetics to suppress the temporal summation that contributes to minimum alveolar concentration? Anesth Analg. 2006 May; 102(5):1412-8.
Dutton RC, Laster MJ, Xing Y, Sonner JM, Raines DE, Solt K, Eger EI. PMID: 16632819.
View in:
PubMed Mentions:
9 Fields:
Translation:
Animals
-
Contrasting roles of the N-methyl-D-aspartate receptor in the production of immobilization by conventional and aromatic anesthetics. Anesth Analg. 2006 May; 102(5):1397-406.
Eger EI, Liao M, Laster MJ, Won A, Popovich J, Raines DE, Solt K, Dutton RC, Cobos FV, Sonner JM. PMID: 16632817.
View in:
PubMed Mentions:
20 Fields:
Translation:
Animals
-
Anaesthesia defined (gentlemen, this is no humbug). Best Pract Res Clin Anaesthesiol. 2006 Mar; 20(1):23-9.
Eger EI, Sonner JM. PMID: 16634411.
View in:
PubMed Mentions:
12 Fields:
Translation:
Humans
-
Hypothermia decreases ethanol MAC in rats. J Anesth. 2006; 20(3):247-50.
Won A, Oh I, Brosnan R, Eger EI, Sonner JM. PMID: 16897251.
View in:
PubMed Mentions:
2 Fields:
Translation:
Animals
-
Beta3-containing gamma-aminobutyric acidA receptors are not major targets for the amnesic and immobilizing actions of isoflurane. Anesth Analg. 2005 Aug; 101(2):412-418.
Liao M, Sonner JM, Jurd R, Rudolph U, Borghese CM, Harris RA, Laster MJ, Eger EI. PMID: 16037154.
View in:
PubMed Mentions:
26 Fields:
Translation:
Animals
-
R (+) etomidate and the photoactivable R (+) azietomidate have comparable anesthetic activity in wild-type mice and comparably decreased activity in mice with a N265M point mutation in the gamma-aminobutyric acid receptor beta3 subunit. Anesth Analg. 2005 Jul; 101(1):131-5, table of contents.
Liao M, Sonner JM, Husain SS, Miller KW, Jurd R, Rudolph U, Eger EI. PMID: 15976219.
View in:
PubMed Mentions:
27 Fields:
Translation:
Animals
-
The effect of three inhaled anesthetics in mice harboring mutations in the GluR6 (kainate) receptor gene. Anesth Analg. 2005 Jul; 101(1):143-8, table of contents.
Sonner JM, Vissel B, Royle G, Maurer A, Gong D, Baron NV, Harrison N, Fanselow M, Eger EI. PMID: 15976221.
View in:
PubMed Mentions:
5 Fields:
Translation:
Animals
-
Administration of epinephrine does not increase learning of fear to tone in rats anesthetized with isoflurane or desflurane. Anesth Analg. 2005 May; 100(5):1333-1337.
Sonner JM, Xing Y, Zhang Y, Maurer A, Fanselow MS, Dutton RC, Eger EI. PMID: 15845679.
View in:
PubMed Mentions:
3 Fields:
Translation:
Animals
-
Alpha 1 subunit-containing GABA type A receptors in forebrain contribute to the effect of inhaled anesthetics on conditioned fear. Mol Pharmacol. 2005 Jul; 68(1):61-8.
Sonner JM, Cascio M, Xing Y, Fanselow MS, Kralic JE, Morrow AL, Korpi ER, Hardy S, Sloat B, Eger EI, Homanics GE. PMID: 15833735.
View in:
PubMed Mentions:
29 Fields:
Translation:
Animals
-
The effect of meperidine on thermoregulation in mice: involvement of alpha2-adrenoceptors. Anesth Analg. 2005 Jan; 100(1):102-106.
Paris A, Ohlendorf C, Marquardt M, Bein B, Sonner JM, Scholz J, Tonner PH. PMID: 15616061.
View in:
PubMed Mentions:
5 Fields:
Translation:
Animals
-
Thiopental produces immobility primarily by supraspinal actions in rats. Anesth Analg. 2005 Jan; 100(1):128-136.
Stabernack C, Zhang Y, Sonner JM, Laster M, Eger EI. PMID: 15616066.
View in:
PubMed Mentions:
4 Fields:
Translation:
Animals
-
Mice with a melanocortin 1 receptor mutation have a slightly greater minimum alveolar concentration than control mice. Anesthesiology. 2004 Aug; 101(2):544-6.
Xing Y, Sonner JM, Eger EI, Cascio M, Sessler DI. PMID: 15277941.
View in:
PubMed Mentions:
6 Fields:
Translation:
Animals
-
Gamma-aminobutyric acidA receptors do not mediate the immobility produced by isoflurane. Anesth Analg. 2004 Jul; 99(1):85-90.
Zhang Y, Sonner JM, Eger EI, Stabernack CR, Laster MJ, Raines DE, Harris RA. PMID: 15281509.
View in:
PubMed Mentions:
15 Fields:
Translation:
AnimalsCells
-
Women appear to have the same minimum alveolar concentration as men: a retrospective study. Anesthesiology. 2003 Nov; 99(5):1059-61.
Eger EI, Laster MJ, Gregory GA, Katoh T, Sonner JM. PMID: 14576539.
View in:
PubMed Mentions:
11 Fields:
Translation:
Humans
-
Inhaled anesthetics and immobility: mechanisms, mysteries, and minimum alveolar anesthetic concentration. Anesth Analg. 2003 Sep; 97(3):718-740.
Sonner JM, Antognini JF, Dutton RC, Flood P, Gray AT, Harris RA, Homanics GE, Kendig J, Orser B, Raines DE, Trudell J, Vissel B, Eger EI. PMID: 12933393.
View in:
PubMed Mentions:
79 Fields:
Translation:
HumansAnimals
-
Blockade of 5-HT2A receptors may mediate or modulate part of the immobility produced by inhaled anesthetics. Anesth Analg. 2003 Aug; 97(2):475-479.
Zhang Y, Laster MJ, Eger EI, Stabernack CR, Sonner JM. PMID: 12873938.
View in:
PubMed Mentions:
5 Fields:
Translation:
Animals
-
Alpha-2 adrenoreceptors probably do not mediate the immobility produced by inhaled anesthetics. Anesth Analg. 2003 Jun; 96(6):1661-1664.
Eger EI, Xing Y, Laster MJ, Sonner JM. PMID: 12760992.
View in:
PubMed Mentions:
2 Fields:
Translation:
Animals
-
Temporal summation governs part of the minimum alveolar concentration of isoflurane anesthesia. Anesthesiology. 2003 Jun; 98(6):1372-7.
Dutton RC, Zhang Y, Stabernack CR, Laster MJ, Sonner JM, Eger EI. PMID: 12766645.
View in:
PubMed Mentions:
5 Fields:
Translation:
Animals
-
Halothane and isoflurane have additive minimum alveolar concentration (MAC) effects in rats. Anesth Analg. 2003 May; 96(5):1350-1353.
Eger EI, Xing Y, Laster M, Sonner J, Antognini JF, Carstens E. PMID: 12707132.
View in:
PubMed Mentions:
5 Fields:
Translation:
Animals
-
Isoflurane antagonizes the capacity of flurothyl or 1,2-dichlorohexafluorocyclobutane to impair fear conditioning to context and tone. Anesth Analg. 2003 Apr; 96(4):1010-1018.
Eger EI, Xing Y, Pearce R, Shafer S, Laster MJ, Zhang Y, Fanselow MS, Sonner JM. PMID: 12651651.
View in:
PubMed Mentions:
2 Fields:
Translation:
Animals
-
GABA(A) receptor blockade antagonizes the immobilizing action of propofol but not ketamine or isoflurane in a dose-related manner. Anesth Analg. 2003 Mar; 96(3):706-712.
Bovill JG, Sonner JM, Zhang Y, Stabernack C, Abaigar W, Xing Y, Laster MJ. PMID: 12598250.
View in:
PubMed Mentions:
29 Fields:
Translation:
Animals
-
Glycine receptors mediate part of the immobility produced by inhaled anesthetics. Anesth Analg. 2003 Jan; 96(1):97-101, table of contents.
Zhang Y, Laster MJ, Hara K, Harris RA, Eger EI, Stabernack CR, Sonner JM. PMID: 12505932.
View in:
PubMed Mentions:
20 Fields:
Translation:
AnimalsCells
-
Spinal N-methyl-d-aspartate receptors may contribute to the immobilizing action of isoflurane. Anesth Analg. 2003 Jan; 96(1):102-7, table of contents.
Stabernack C, Sonner JM, Laster M, Zhang Y, Xing Y, Sharma M, Eger EI. PMID: 12505933.
View in:
PubMed Mentions:
14 Fields:
Translation:
Animals
-
Heteromeric nicotinic inhibition by isoflurane does not mediate MAC or loss of righting reflex. Anesthesiology. 2002 Oct; 97(4):902-5.
Flood P, Sonner JM, Gong D, Coates KM. PMID: 12357157.
View in:
PubMed Mentions:
14 Fields:
Translation:
Animals
-
Issues in the design and interpretation of minimum alveolar anesthetic concentration (MAC) studies. Anesth Analg. 2002 Sep; 95(3):609-14, table of contents.
Sonner JM. PMID: 12198046.
View in:
PubMed Mentions:
22 Fields:
Translation:
Animals
-
Isoflurane hyperalgesia is modulated by nicotinic inhibition. Anesthesiology. 2002 Jul; 97(1):192-8.
Flood P, Sonner JM, Gong D, Coates KM. PMID: 12131122.
View in:
PubMed Mentions:
13 Fields:
Translation:
Animals
-
Acetylcholine receptors do not mediate the immobilization produced by inhaled anesthetics. Anesth Analg. 2002 Jun; 94(6):1500-4, table of contents.
Eger EI, Zhang Y, Laster M, Flood P, Kendig JJ, Sonner JM. PMID: 12032015.
View in:
PubMed Mentions:
8 Fields:
Translation:
Animals
-
Acetylcholine receptors do not mediate isoflurane's actions on spinal cord in vitro. Anesth Analg. 2002 Jun; 94(6):1495-9, table of contents.
Wong SM, Sonner JM, Kendig JJ. PMID: 12032014.
View in:
PubMed Mentions:
1 Fields:
Translation:
Animals
-
Do sevoflurane and desflurane differ in upper airway reactivity? Anesthesiology. 2002 May; 96(5):1274-5; author reply 1275-6.
Sonner J, Fisher DM. PMID: 11981176.
View in:
PubMed Mentions: Fields:
Translation:
Humans
-
Isoflurane causes anterograde but not retrograde amnesia for pavlovian fear conditioning. Anesthesiology. 2002 May; 96(5):1223-9.
Dutton RC, Maurer AJ, Sonner JM, Fanselow MS, Laster MJ, Eger EI. PMID: 11981164.
View in:
PubMed Mentions:
15 Fields:
Translation:
Animals
-
Short-term memory resists the depressant effect of the nonimmobilizer 1-2-dichlorohexafluorocyclobutane (2N) more than long-term memory. Anesth Analg. 2002 Mar; 94(3):631-9; table of contents.
Dutton RC, Maurer AJ, Sonner JM, Fanselow MS, Laster MJ, Eger EI. PMID: 11867388.
View in:
PubMed Mentions:
4 Fields:
Translation:
Animals