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Joachim Li, MD, PhD

TitleProfessor
SchoolUCSF School of Medicine
DepartmentMicrobiology and Immunology
Address600 16th Street
San Francisco CA 94158
Phone415-476-8782
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    Collapse Research 
    Collapse Research Activities and Funding
    Yeast Chromosome Structure, Replication and Segregation
    NIH/NCI R13CA094910Jun 28, 2002 - Jun 27, 2003
    Role: Principal Investigator
    Role of regulation of eukaryotic DNA replication in preserving genome stability
    NIH/NIGMS R01GM059704Jul 1, 2000 - Apr 30, 2020
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Hanlon SL, Li J. Re-replication of a centromere induces chromosomal instability and aneuploidy. PLoS Genet. 2015 Apr; 11(4):e1005039. PMID: 25901968; PMCID: PMC4406714.
    2. Richardson CD, Li J. Regulatory mechanisms that prevent re-initiation of DNA replication can be locally modulated at origins by nearby sequence elements. PLoS Genet. 2014 Jun; 10(6):e1004358. PMID: 24945837; PMCID: PMC4063666.
    3. Finn KJ, Li J. Single-stranded annealing induced by re-initiation of replication origins provides a novel and efficient mechanism for generating copy number expansion via non-allelic homologous recombination. PLoS Genet. 2013; 9(1):e1003192. PMID: 23300490; PMCID: PMC3536649.
    4. Green BM, Finn KJ, Li J. Loss of DNA replication control is a potent inducer of gene amplification. Science. 2010 Aug 20; 329(5994):943-6. PMID: 20724634; PMCID: PMC3700424.
    5. Moses AM, Liku ME, Li J, Durbin R. Regulatory evolution in proteins by turnover and lineage-specific changes of cyclin-dependent kinase consensus sites. Proc Natl Acad Sci U S A. 2007 Nov 06; 104(45):17713-8. PMID: 17978194; PMCID: PMC2077061.
    6. Green BM, Morreale RJ, Ozaydin B, Derisi JL, Li J. Genome-wide mapping of DNA synthesis in Saccharomyces cerevisiae reveals that mechanisms preventing reinitiation of DNA replication are not redundant. Mol Biol Cell. 2006 May; 17(5):2401-14. PMID: 16481397; PMCID: PMC1446083.
    7. Liku ME, Nguyen VQ, Rosales AW, Irie K, Li J. CDK phosphorylation of a novel NLS-NES module distributed between two subunits of the Mcm2-7 complex prevents chromosomal rereplication. Mol Biol Cell. 2005 Oct; 16(10):5026-39. PMID: 16093348; PMCID: PMC1237101.
    8. Green BM, Li J. Loss of rereplication control in Saccharomyces cerevisiae results in extensive DNA damage. Mol Biol Cell. 2005 Jan; 16(1):421-32. PMID: 15537702; PMCID: PMC539184.
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