Jose Angel Nicolas Avila, PhD

Title(s)Assistant Professor, Cardiovascular Research Inst
SchoolSchool of Medicine
Address555 Mission Bay Blvd South, #352Q
San Francisco CA 94158
ORCID ORCID Icon0000-0002-8301-7216 Additional info
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    Collapse Biography 
    Collapse Education and Training
    Spanish National Center for Cardiovascular Research, Madrid (Spain)Postdoctoral Fellow2024Immunology
    Autonoma de Madrid University, Madrid (Spain)PhD2020Molecular Biosciences
    Autonoma de Madrid University, Madrid (Spain)MS2014Molecular and Cell Biology
    Santiago de Compostela University, Santiago de Compostela (Spain)BS2013Biology
    Collapse Awards and Honors
    Cellular Aging and Metabolism Symposium2022Best oral presentation award
    Keystone Symposia2022Trainee scholarship to attend a Keystone Meeting
    Constantes y Vitales, A3media and AXA foundation2021Best Spanish Biomedical Publication of the Year Award
    Hijos de Rivera S.A.2021Scientific work with highest social impact award
    Universidad Autonoma de Madrid2021PhD Thesis extraordinary prize, 2019/2020 promotion
    Cell Press2020Cover in Cell journal, Volume 183, Number 1
    Keystone Symposia2020Trainee scholarship to attend a Keystone Meeting
    International Society for Heart Research (ISHR)2020Young Investigator Competition Awards (YICA), junior tier
    Rockefeller University Press2018Cover in Journal of Experimental Medicine, Volume 215, Issue 11
    VI Annual Meeting of Immunology Society from Comunidad de Madrid2015Best basic research work award
    Ministry of Economy and Competitiveness, Spanish Government2014  - 2018Severo Ochoa Predoctoral Fellowship
    Spanish National Center for Cardiovascular Research2013  - 2014MASTER-program fellowship
    Spanish National Center for Cardiovascular Research2013CICERONE-program internship

    Collapse Overview 
    Collapse Overview
    My research interests focus on the cellular and molecular mechanisms by which immune cells contribute to organismal physiology and pathology. During my PhD, I developed tools and strategies to asses the function of immune cells and contributed with my expertise to several studies defining their roles in different tissues and contexts. A particularly relevant contribution was the discovery of heterophagy, an unpreviously characterized form of cell cooperation by wich macrophages, an specific immune cell type, help cardiac cells to stay healthy by removing their wasted components. Further, my work identified macrophages as important players at cardiac physiology, as their elimination or interference with phagocytosis results in cardiac metabolic dysfunction. For these discoveries I received the Young Investigator Competitive Award from the International Society for Heart Research, among other honours. In my postdoctoral stage, I have dedicated my efforts to testing the relevance of heterophagy in other tissues and pathological contexts. My results show that many other tissues in the body resort to heterophagy and failure of this cell cooperation mechanism underlies age-related cardiomyopathy. In 2024 I joined the University of California San Francisco (UCSF) as Principal Investigator to explore the molecular mechanisms that underlie the communication between immune cells and other tissue components and develop strategies to modulate them with the aim to improve cardiac and organismal health.

    B.S. Santiago de Compostela University.
    M.S. Autonoma de Madrid University.
    Ph.D. Autonoma de Madrid University (summa cum laude and extraordinary prize).
    Postdoc. Spanish National Center for Cardiovascular Research (Dr. Andres Hidalgo laboratory).
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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. TREM2+ macrophages are guardians of the heart. Nat Metab. 2023 Jan; 5(1):13-15. Nicolás-Ávila JÁ, Hidalgo A. PMID: 36635448.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    2. Immune riders on the cardiac STORM. Nature Cardiovascular Research. 2022; 1(1):603-604. Nicolás-Ávila, J. Á., & Hidalgo, A. View Publication.
    3. Macrophages, Metabolism and Heterophagy in the Heart. Circ Res. 2022 Feb 04; 130(3):418-431. Nicolás-Ávila JA, Pena-Couso L, Muñoz-Cánoves P, Hidalgo A. PMID: 35113662.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    4. Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism. Nat Cancer. 2021 Dec; 2(12):1387-1405. García-Silva S, Benito-Martín A, Nogués L, Hernández-Barranco A, Mazariegos MS, Santos V, Hergueta-Redondo M, Ximénez-Embún P, Kataru RP, Lopez AA, Merino C, Sánchez-Redondo S, Graña-Castro O, Matei I, Nicolás-Avila JÁ, Torres-Ruiz R, Rodríguez-Perales S, Martínez L, Pérez-Martínez M, Mata G, Szumera-Cieckiewicz A, Kalinowska I, Saltari A, Martínez-Gómez JM, Hogan SA, Saragovi HU, Ortega S, Garcia-Martin C, Boskovic J, Levesque MP, Rutkowski P, Hidalgo A, Muñoz J, Megías D, Mehrara BJ, Lyden D, Peinado H. PMID: 34957415; PMCID: PMC8697753.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    5. Human influenza A virus causes myocardial and cardiac-specific conduction system infections associated with early inflammation and premature death. Cardiovasc Res. 2021 Feb 22; 117(3):876-889. Filgueiras-Rama D, Vasilijevic J, Jalife J, Noujaim SF, Alfonso JM, Nicolas-Avila JA, Gutierrez C, Zamarreño N, Hidalgo A, Bernabé A, Cop CP, Ponce-Balbuena D, Guerrero-Serna G, Calle D, Desco M, Ruiz-Cabello J, Nieto A, Falcon A. PMID: 32346730; PMCID: PMC7898948.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    6. Isolation of exophers from cardiomyocyte-reporter mouse strains by fluorescence-activated cell sorting. STAR Protoc. 2021 Mar 19; 2(1):100286. Nicolás-Ávila JÁ, Sánchez-Diaz M, Hidalgo A. PMID: 33490991; PMCID: PMC7811054.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    7. Co-option of Neutrophil Fates by Tissue Environments. Cell. 2020 Nov 25; 183(5):1282-1297.e18. Ballesteros I, Rubio-Ponce A, Genua M, Lusito E, Kwok I, Fernández-Calvo G, Khoyratty TE, van Grinsven E, González-Hernández S, Nicolás-Ávila JÁ, Vicanolo T, Maccataio A, Benguría A, Li JL, Adrover JM, Aroca-Crevillen A, Quintana JA, Martín-Salamanca S, Mayo F, Ascher S, Barbiera G, Soehnlein O, Gunzer M, Ginhoux F, Sánchez-Cabo F, Nistal-Villán E, Schulz C, Dopazo A, Reinhardt C, Udalova IA, Ng LG, Ostuni R, Hidalgo A. PMID: 33098771.
      View in: PubMed   Mentions: 130     Fields:    Translation:AnimalsCells
    8. A Network of Macrophages Supports Mitochondrial Homeostasis in the Heart. Cell. 2020 Oct 01; 183(1):94-109.e23. Nicolás-Ávila JA, Lechuga-Vieco AV, Esteban-Martínez L, Sánchez-Díaz M, Díaz-García E, Santiago DJ, Rubio-Ponce A, Li JL, Balachander A, Quintana JA, Martínez-de-Mena R, Castejón-Vega B, Pun-García A, Través PG, Bonzón-Kulichenko E, García-Marqués F, Cussó L, A-González N, González-Guerra A, Roche-Molina M, Martin-Salamanca S, Crainiciuc G, Guzmán G, Larrazabal J, Herrero-Galán E, Alegre-Cebollada J, Lemke G, Rothlin CV, Jimenez-Borreguero LJ, Reyes G, Castrillo A, Desco M, Muñoz-Cánoves P, Ibáñez B, Torres M, Ng LG, Priori SG, Bueno H, Vázquez J, Cordero MD, Bernal JA, Enríquez JA, Hidalgo A. PMID: 32937105.
      View in: PubMed   Mentions: 215     Fields:    Translation:HumansAnimalsCells
    9. Cell identity and nucleo-mitochondrial genetic context modulate OXPHOS performance and determine somatic heteroplasmy dynamics. Sci Adv. 2020 Jul; 6(31):eaba5345. Lechuga-Vieco AV, Latorre-Pellicer A, Johnston IG, Prota G, Gileadi U, Justo-Méndez R, Acín-Pérez R, Martínez-de-Mena R, Fernández-Toro JM, Jimenez-Blasco D, Mora A, Nicolás-Ávila JA, Santiago DJ, Priori SG, Bolaños JP, Sabio G, Criado LM, Ruíz-Cabello J, Cerundolo V, Jones NS, Enríquez JA. PMID: 32832682; PMCID: PMC7439646.
      View in: PubMed   Mentions: 21     Fields:    
    10. Mitochondrial Adaptations in the Growing Heart. Trends Endocrinol Metab. 2020 Apr; 31(4):308-319. Sánchez-Díaz M, Nicolás-Ávila JÁ, Cordero MD, Hidalgo A. PMID: 32035734.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    11. Locally renewing resident synovial macrophages provide a protective barrier for the joint. Nature. 2019 Aug; 572(7771):670-675. Culemann S, Grüneboom A, Nicolás-Ávila JÁ, Weidner D, Lämmle KF, Rothe T, Quintana JA, Kirchner P, Krljanac B, Eberhardt M, Ferrazzi F, Kretzschmar E, Schicht M, Fischer K, Gelse K, Faas M, Pfeifle R, Ackermann JA, Pachowsky M, Renner N, Simon D, Haseloff RF, Ekici AB, Bäuerle T, Blasig IE, Vera J, Voehringer D, Kleyer A, Paulsen F, Schett G, Hidalgo A, Krönke G. PMID: 31391580; PMCID: PMC6805223.
      View in: PubMed   Mentions: 195     Fields:    Translation:HumansAnimalsCells
    12. Neutrophils instruct homeostatic and pathological states in naive tissues. J Exp Med. 2018 Nov 05; 215(11):2778-2795. Casanova-Acebes M, Nicolás-Ávila JA, Li JL, García-Silva S, Balachander A, Rubio-Ponce A, Weiss LA, Adrover JM, Burrows K, A-González N, Ballesteros I, Devi S, Quintana JA, Crainiciuc G, Leiva M, Gunzer M, Weber C, Nagasawa T, Soehnlein O, Merad M, Mortha A, Ng LG, Peinado H, Hidalgo A. PMID: 30282719; PMCID: PMC6219739.
      View in: PubMed   Mentions: 114     Fields:    Translation:AnimalsCells
    13. Specialized functions of resident macrophages in brain and heart. J Leukoc Biol. 2018 Oct; 104(4):743-756. Nicolás-Ávila JA, Hidalgo A, Ballesteros I. PMID: 29947422.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    14. Phagocytosis imprints heterogeneity in tissue-resident macrophages. J Exp Med. 2017 May 01; 214(5):1281-1296. A-Gonzalez N, Quintana JA, García-Silva S, Mazariegos M, González de la Aleja A, Nicolás-Ávila JA, Walter W, Adrover JM, Crainiciuc G, Kuchroo VK, Rothlin CV, Peinado H, Castrillo A, Ricote M, Hidalgo A. PMID: 28432199; PMCID: PMC5413334.
      View in: PubMed   Mentions: 133     Fields:    Translation:AnimalsCells
    15. Neutrophils in Homeostasis, Immunity, and Cancer. Immunity. 2017 Jan 17; 46(1):15-28. Nicolás-Ávila JÁ, Adrover JM, Hidalgo A. PMID: 28099862.
      View in: PubMed   Mentions: 193     Fields:    Translation:HumansAnimalsCells
    16. Aging: A Temporal Dimension for Neutrophils. Trends Immunol. 2016 May; 37(5):334-345. Adrover JM, Nicolás-Ávila JA, Hidalgo A. PMID: 27083489.
      View in: PubMed   Mentions: 92     Fields:    Translation:HumansAnimalsCells
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