Karen Gylys, PhD, MS, BSN

Title(s)Professor, Physiological Nursing
SchoolSchool of Nursing
PronounsShe/Her/Hers
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    Collapse Overview
    Karen Hoppens Gylys is a nurse and a neuroscientist who joined the faculty of the UCSF School of Nursing in 2023 as Chair of the Physiological Nursing Department. Dr. Gylys was previously a faculty member in the UCLA School of Nursing and the UCLA Brain Research Institute, and a member of the UCLA Neuroscience Interdepartmental Program since 1998.

    Dr. Gylys earned a diploma and then a B.S. degree in Nursing, followed by a M.S. degree in Human Development at the University of Texas, Dallas. She received her Ph.D. in Neuroscience, with a major in neuropharmacology, at UCLA in 1993, and did postdoctoral work on molecular mechanisms of opioid tolereance.

    Her laboratory research is focused on understanding the dysfunction and loss of synapses that occurs in Alzheimer's disease (AD), and she has pioneered the use of flow cytometry for the analysis of synaptosomes. Her projects use primarily human postmortem AD samples and mouse models of the disease. Research interests include neuroinflammation and APOE risk for AD, the single biggest genetic risk, which can also be also protective. Recent projects have isolated brain cell types from human postmortem samples in order to study microglial and astrocyte effects on AD progression. New projects look at exosomes as biomarkers for AD, and as mechanisms in AD pathology and signaling between cortical cell types.

    Collapse Research 
    Collapse Research Activities and Funding
    TS21 Effects on Senescence/SASP in neurons, glia and cell-specific exosomes, and spread of phenotype in vitro
    NIH R21AG082014Jun 15, 2023 - Feb 28, 2025
    Role: Principal Investigator
    Tau pathology in neurons, glia, and cell type-specific exosomes from cryopreserved AD cortex
    NIH R21AG063767Jan 15, 2020 - Dec 31, 2021
    Role: Co-Principal Investigator
    Depolarization-induced tau and exosome release from synapses in AD
    NIH R21AG051946Aug 1, 2016 - May 31, 2019
    Role: Principal Investigator
    ApoE and Cholesterol Effects on Amyloid-beta in Synaptic Terminals in AD
    NIH R01AG027465Mar 15, 2008 - Feb 28, 2014
    Role: Principal Investigator
    ApoE and cholesterol effects on amyloid beta in synaptic terminals in AD
    NIH R56AG027465Dec 1, 2005 - Aug 31, 2017
    Role: Principal Investigator
    AGONIST INDUCED CHANGES IN DELTA OPIOID RECEPTORS
    NIH F32DA005609Aug 31, 1994
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Simultaneous isolation of intact brain cells and cell-specific extracellular vesicles from cryopreserved Alzheimer's disease cortex. J Neurosci Methods. 2024 06; 406:110137. Melnik M, Miyoshi E, Ma R, Corrada M, Kawas C, Bohannan R, Caraway C, Miller CA, Hinman JD, John V, Bilousova T, Gylys KH. PMID: 38626853.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    2. Postsynaptic Protein Shank3a Deficiency Synergizes with Alzheimer's Disease Neuropathology to Impair Cognitive Performance in the 3xTg-AD Murine Model. J Neurosci. 2023 06 28; 43(26):4941-4954. Landry O, François A, Oye Mintsa Mi-Mba MF, Traversy MT, Tremblay C, Emond V, Bennett DA, Gylys KH, Buxbaum JD, Calon F. PMID: 37253603; PMCID: PMC10312061.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    3. Multi-Omics Analysis of Microglial Extracellular Vesicles From Human Alzheimer's Disease Brain Tissue Reveals Disease-Associated Signatures. Front Pharmacol. 2021; 12:766082. Cohn W, Melnik M, Huang C, Teter B, Chandra S, Zhu C, McIntire LB, John V, Gylys KH, Bilousova T. PMID: 34925024; PMCID: PMC8675946.
      View in: PubMed   Mentions: 50  
    4. Correction to: α-Synuclein in blood exosomes immunoprecipitated using neuronal and oligodendroglial markers distinguishes Parkinson's disease from multiple system atrophy. Acta Neuropathol. 2021 Sep; 142(3):513. Dutta S, Hornung S, Kruayatidee A, Maina KN, Del Rosario I, Paul KC, Wong DY, Duarte Folle A, Markovic D, Palma JA, Serrano GE, Adler CH, Perlman SL, Poon WW, Kang UJ, Alcalay RN, Sklerov M, Gylys KH, Kaufmann H, Fogel BL, Bronstein JM, Ritz B, Bitan G. PMID: 34028589; PMCID: PMC8587231.
      View in: PubMed   Mentions: 1     Fields:    
    5. Exosomal tau with seeding activity is released from Alzheimer's disease synapses, and seeding potential is associated with amyloid beta. Lab Invest. 2021 12; 101(12):1605-1617. Miyoshi E, Bilousova T, Melnik M, Fakhrutdinov D, Poon WW, Vinters HV, Miller CA, Corrada M, Kawas C, Bohannan R, Caraway C, Elias C, Maina KN, Campagna JJ, John V, Gylys KH. PMID: 34462532; PMCID: PMC8590975.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    6. Correction to: Pharmacological inhibition of nSMase2 reduces brain exosome release and α-synuclein pathology in a Parkinson's disease model. Mol Brain. 2021 Jul 08; 14(1):108. Zhu C, Bilousova T, Focht S, Jun M, Elias CJ, Melnik M, Chandra S, Campagna J, Cohn W, Hatami A, Spilman P, Gylys KH, John V. PMID: 34238327; PMCID: PMC8265003.
      View in: PubMed   Mentions: 2     Fields:    
    7. α-Synuclein in blood exosomes immunoprecipitated using neuronal and oligodendroglial markers distinguishes Parkinson's disease from multiple system atrophy. Acta Neuropathol. 2021 09; 142(3):495-511. Dutta S, Hornung S, Kruayatidee A, Maina KN, Del Rosario I, Paul KC, Wong DY, Duarte Folle A, Markovic D, Palma JA, Serrano GE, Adler CH, Perlman SL, Poon WW, Kang UJ, Alcalay RN, Sklerov M, Gylys KH, Kaufmann H, Fogel BL, Bronstein JM, Ritz B, Bitan G. PMID: 33991233; PMCID: PMC8357708.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansCells
    8. Pharmacological inhibition of nSMase2 reduces brain exosome release and α-synuclein pathology in a Parkinson's disease model. Mol Brain. 2021 04 19; 14(1):70. Zhu C, Bilousova T, Focht S, Jun M, Elias CJ, Melnik M, Chandra S, Campagna J, Cohn W, Hatami A, Spilman P, Gylys KH, John V. PMID: 33875010; PMCID: PMC8056538.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    9. Dual Neutral Sphingomyelinase-2/Acetylcholinesterase Inhibitors for the Treatment of Alzheimer's Disease. ACS Chem Biol. 2020 06 19; 15(6):1671-1684. Bilousova T, Simmons BJ, Knapp RR, Elias CJ, Campagna J, Melnik M, Chandra S, Focht S, Zhu C, Vadivel K, Jagodzinska B, Cohn W, Spilman P, Gylys KH, Garg NK, John V. PMID: 32352753; PMCID: PMC8297715.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    10. Frequency of the TREM2 R47H Variant in Various Neurodegenerative Disorders. Alzheimer Dis Assoc Disord. 2019 Oct-Dec; 33(4):327-330. Ayer AH, Wojta K, Ramos EM, Dokuru D, Chen JA, Karydas AM, Papatriantafyllou JD, Agiomyrgiannakis D, Kamtsadeli V, Tsinia N, Sali D, Gylys KH, Agosta F, Filippi M, Small GW, Bennett DA, Gearing M, Juncos JL, Kramer J, Lee SE, Yokoyama JS, Mendez MF, Chui H, Zarow C, Ringman JM, Kilic U, Babacan-Yildiz G, Levey A, DeCarli CS, Cotman CW, Boxer AL, Miller BL, Coppola G. PMID: 31513029; PMCID: PMC7050643.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    11. Apolipoprotein E/Amyloid-β Complex Accumulates in Alzheimer Disease Cortical Synapses via Apolipoprotein E Receptors and Is Enhanced by APOE4. Am J Pathol. 2019 08; 189(8):1621-1636. Bilousova T, Melnik M, Miyoshi E, Gonzalez BL, Poon WW, Vinters HV, Miller CA, Corrada MM, Kawas C, Hatami A, Albay R, Glabe C, Gylys KH. PMID: 31108099; PMCID: PMC6680253.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    12. Suppression of tau propagation using an inhibitor that targets the DK-switch of nSMase2. Biochem Biophys Res Commun. 2018 05 23; 499(4):751-757. Bilousova T, Elias C, Miyoshi E, Alam MP, Zhu C, Campagna J, Vadivel K, Jagodzinska B, Gylys KH, John V. PMID: 29604274; PMCID: PMC5956110.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    13. Neuronal pentraxin 1: A synaptic-derived plasma biomarker in Alzheimer's disease. Neurobiol Dis. 2018 06; 114:120-128. Ma QL, Teng E, Zuo X, Jones M, Teter B, Zhao EY, Zhu C, Bilousova T, Gylys KH, Apostolova LG, LaDu MJ, Hossain MA, Frautschy SA, Cole GM. PMID: 29501530; PMCID: PMC8092920.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    14. Tau Spread, Apolipoprotein E, Inflammation, and More: Rapidly Evolving Basic Science in Alzheimer Disease. Neurol Clin. 2017 05; 35(2):175-190. Gonzalez B, Abud EM, Abud AM, Poon WW, Gylys KH. PMID: 28410655; PMCID: PMC5417853.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    15. iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases. Neuron. 2017 Apr 19; 94(2):278-293.e9. Abud EM, Ramirez RN, Martinez ES, Healy LM, Nguyen CHH, Newman SA, Yeromin AV, Scarfone VM, Marsh SE, Fimbres C, Caraway CA, Fote GM, Madany AM, Agrawal A, Kayed R, Gylys KH, Cahalan MD, Cummings BJ, Antel JP, Mortazavi A, Carson MJ, Poon WW, Blurton-Jones M. PMID: 28426964; PMCID: PMC5482419.
      View in: PubMed   Mentions: 491     Fields:    Translation:HumansAnimalsCells
    16. Flow Cytometry Analysis and Quantitative Characterization of Tau in Synaptosomes from Alzheimer's Disease Brains. Methods Mol Biol. 2017; 1523:273-284. Gylys KH, Bilousova T. PMID: 27975256; PMCID: PMC5755961.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    17. Pharmacological Rescue of Long-Term Potentiation in Alzheimer Diseased Synapses. J Neurosci. 2017 02 01; 37(5):1197-1212. Prieto GA, Trieu BH, Dang CT, Bilousova T, Gylys KH, Berchtold NC, Lynch G, Cotman CW. PMID: 27986924; PMCID: PMC5296796.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    18. Altered brain energetics induces mitochondrial fission arrest in Alzheimer's Disease. Sci Rep. 2016 Jan 05; 6:18725. Zhang L, Trushin S, Christensen TA, Bachmeier BV, Gateno B, Schroeder A, Yao J, Itoh K, Sesaki H, Poon WW, Gylys KH, Patterson ER, Parisi JE, Diaz Brinton R, Salisbury JL, Trushina E. PMID: 26729583; PMCID: PMC4700525.
      View in: PubMed   Mentions: 111     Fields:    Translation:AnimalsCells
    19. Synaptic Amyloid-β Oligomers Precede p-Tau and Differentiate High Pathology Control Cases. Am J Pathol. 2016 Jan; 186(1):185-98. Bilousova T, Miller CA, Poon WW, Vinters HV, Corrada M, Kawas C, Hayden EY, Teplow DB, Glabe C, Albay R, Cole GM, Teng E, Gylys KH. PMID: 26718979; PMCID: PMC4715217.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansAnimalsCells
    20. Alzheimer risk genes modulate the relationship between plasma apoE and cortical PiB binding. Neurol Genet. 2015 Oct; 1(3):e22. Lazaris A, Hwang KS, Goukasian N, Ramirez LM, Eastman J, Blanken AE, Teng E, Gylys K, Cole G, Saykin AJ, Shaw LM, Trojanowski JQ, Jagust WJ, Weiner MW, Apostolova LG, Alzheimer's Disease Neuroimaging Initiative. PMID: 27066559; PMCID: PMC4809461.
      View in: PubMed   Mentions: 7  
    21. Plasma BDNF levels associate with Pittsburgh compound B binding in the brain. Alzheimers Dement (Amst). 2015 Jun 01; 1(2):187-193. Hwang KS, Lazaris AS, Eastman JA, Teng E, Thompson PM, Gylys KH, Cole GM, Apostolova LG, Alzheimer's Disease Neuroimaging Initiative. PMID: 26207261; PMCID: PMC4507280.
      View in: PubMed   Mentions: 11  
    22. Loss of endophilin-B1 exacerbates Alzheimer's disease pathology. Brain. 2015 Jul; 138(Pt 7):2005-19. Wang DB, Kinoshita Y, Kinoshita C, Uo T, Sopher BL, Cudaback E, Keene CD, Bilousova T, Gylys K, Case A, Jayadev S, Wang HG, Garden GA, Morrison RS. PMID: 25981964; PMCID: PMC4836404.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    23. Pre-synaptic C-terminal truncated tau is released from cortical synapses in Alzheimer's disease. J Neurochem. 2015 May; 133(3):368-79. Sokolow S, Henkins KM, Bilousova T, Gonzalez B, Vinters HV, Miller CA, Cornwell L, Poon WW, Gylys KH. PMID: 25393609; PMCID: PMC4397171.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansCells
    24. Low plasma ApoE levels are associated with smaller hippocampal size in the Alzheimer's disease neuroimaging initiative cohort. Dement Geriatr Cogn Disord. 2015; 39(3-4):154-66. Teng E, Chow N, Hwang KS, Thompson PM, Gylys KH, Cole GM, Jack CR, Shaw LM, Trojanowski JQ, Soares HD, Weiner MW, Apostolova LG, Alzheimer’s Disease Neuroimaging Initiative. PMID: 25547651; PMCID: PMC4323932.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    25. rLOAD: does sex mediate the effect of acute antiplatelet loading on stroke outcome. Biol Sex Differ. 2014; 5:9. Meyer DM, Eastwood JA, Compton MP, Gylys K, Zivin JA. PMID: 25061508; PMCID: PMC4109774.
      View in: PubMed   Mentions: 1     Fields:    
    26. Antiplatelet loading improves behavioral outcome in a rabbit model of stroke. Stroke. 2013 Nov; 44(11):3246-8. Meyer DM, Compton P, Eastwood JA, Gylys K, Zivin JA. PMID: 23982714.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    27. Levels of soluble apolipoprotein E/amyloid-β (Aβ) complex are reduced and oligomeric Aβ increased with APOE4 and Alzheimer disease in a transgenic mouse model and human samples. J Biol Chem. 2013 Feb 22; 288(8):5914-26. Tai LM, Bilousova T, Jungbauer L, Roeske SK, Youmans KL, Yu C, Poon WW, Cornwell LB, Miller CA, Vinters HV, Van Eldik LJ, Fardo DW, Estus S, Bu G, Gylys KH, Ladu MJ. PMID: 23293020; PMCID: PMC3581407.
      View in: PubMed   Mentions: 89     Fields:    Translation:HumansAnimalsCells
    28. Conformation-dependent oligomers in cerebrospinal fluid of presymptomatic familial Alzheimer's disease mutation carriers. Dement Geriatr Cogn Dis Extra. 2012 Jan; 2(1):652-7. Ringman JM, Tomic JL, Coppola G, Elashoff D, Gylys KH, Glabe CG. PMID: 23341831; PMCID: PMC3551434.
      View in: PubMed   Mentions: 4  
    29. Oral curcumin for Alzheimer's disease: tolerability and efficacy in a 24-week randomized, double blind, placebo-controlled study. Alzheimers Res Ther. 2012; 4(5):43. Ringman JM, Frautschy SA, Teng E, Begum AN, Bardens J, Beigi M, Gylys KH, Badmaev V, Heath DD, Apostolova LG, Porter V, Vanek Z, Marshall GA, Hellemann G, Sugar C, Masterman DL, Montine TJ, Cummings JL, Cole GM. PMID: 23107780; PMCID: PMC3580400.
      View in: PubMed   Mentions: 175     Fields:    
    30. Plasma signaling proteins in persons at genetic risk for Alzheimer disease: influence of APOE genotype. Arch Neurol. 2012 Jun; 69(6):757-64. Ringman JM, Elashoff D, Geschwind DH, Welsh BT, Gylys KH, Lee C, Cummings JL, Cole GM. PMID: 22689192; PMCID: PMC3668092.
      View in: PubMed   Mentions: 34     Fields:    Translation:Humans
    31. Extensive p-tau pathology and SDS-stable p-tau oligomers in Alzheimer's cortical synapses. Brain Pathol. 2012 Nov; 22(6):826-33. Henkins KM, Sokolow S, Miller CA, Vinters HV, Poon WW, Cornwell LB, Saing T, Gylys KH. PMID: 22486774; PMCID: PMC3410970.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    32. Plasma methionine sulfoxide in persons with familial Alzheimer's disease mutations. Dement Geriatr Cogn Disord. 2012; 33(4):219-25. Ringman JM, Fithian AT, Gylys K, Cummings JL, Coppola G, Elashoff D, Pratico D, Moskovitz J, Bitan G. PMID: 22584618; PMCID: PMC3568669.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    33. Cerebrospinal fluid biomarkers and proximity to diagnosis in preclinical familial Alzheimer's disease. Dement Geriatr Cogn Disord. 2012; 33(1):1-5. Ringman JM, Coppola G, Elashoff D, Rodriguez-Agudelo Y, Medina LD, Gylys K, Cummings JL, Cole GM. PMID: 22343824; PMCID: PMC3696356.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    34. Proteomic changes in cerebrospinal fluid of presymptomatic and affected persons carrying familial Alzheimer disease mutations. Arch Neurol. 2012 Jan; 69(1):96-104. Ringman JM, Schulman H, Becker C, Jones T, Bai Y, Immermann F, Cole G, Sokolow S, Gylys K, Geschwind DH, Cummings JL, Wan HI. PMID: 22232349; PMCID: PMC3632731.
      View in: PubMed   Mentions: 60     Fields:    Translation:Humans
    35. Isolation of synaptic terminals from Alzheimer's disease cortex. Cytometry A. 2012 Mar; 81(3):248-54. Sokolow S, Henkins KM, Williams IA, Vinters HV, Schmid I, Cole GM, Gylys KH. PMID: 22213704; PMCID: PMC3315390.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    36. Apolipoprotein E level and cholesterol are associated with reduced synaptic amyloid beta in Alzheimer's disease and apoE TR mouse cortex. Acta Neuropathol. 2012 Jan; 123(1):39-52. Arold S, Sullivan P, Bilousova T, Teng E, Miller CA, Poon WW, Vinters HV, Cornwell LB, Saing T, Cole GM, Gylys KH. PMID: 22020632; PMCID: PMC3404604.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    37. Preferential accumulation of amyloid-beta in presynaptic glutamatergic terminals (VGluT1 and VGluT2) in Alzheimer's disease cortex. Neurobiol Dis. 2012 Jan; 45(1):381-7. Sokolow S, Luu SH, Nandy K, Miller CA, Vinters HV, Poon WW, Gylys KH. PMID: 21914482; PMCID: PMC3339276.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansCells
    38. AD synapses contain abundant Aβ monomer and multiple soluble oligomers, including a 56-kDa assembly. Neurobiol Aging. 2012 Aug; 33(8):1545-55. Sokolow S, Henkins KM, Bilousova T, Miller CA, Vinters HV, Poon W, Cole GM, Gylys KH. PMID: 21741125; PMCID: PMC3193864.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    39. Sex differences in antiplatelet response in ischemic stroke. Womens Health (Lond). 2011 Jul; 7(4):465-74. Meyer DM, Eastwood JA, Compton MP, Gylys K, Zivin JA, Ovbiagele B. PMID: 21790339; PMCID: PMC3167689.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    40. Longitudinal change in CSF biomarkers in a presymptomatic carrier of an APP mutation. Neurology. 2011 Jun 14; 76(24):2124-5. Ringman JM, Taylor K, Teng E, Coppola G, Gylys K. PMID: 21562250; PMCID: PMC3111239.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    41. High levels of synaptosomal Na(+)-Ca(2+) exchangers (NCX1, NCX2, NCX3) co-localized with amyloid-beta in human cerebral cortex affected by Alzheimer's disease. Cell Calcium. 2011 Apr; 49(4):208-16. Sokolow S, Luu SH, Headley AJ, Hanson AY, Kim T, Miller CA, Vinters HV, Gylys KH. PMID: 21382638; PMCID: PMC3084347.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    42. Biochemical, neuropathological, and neuroimaging characteristics of early-onset Alzheimer's disease due to a novel PSEN1 mutation. Neurosci Lett. 2011 Jan 10; 487(3):287-92. Ringman JM, Gylys KH, Medina LD, Fox M, Kepe V, Flores DL, Apostolova LG, Barrio JR, Small G, Silverman DH, Siu E, Cederbaum S, Hecimovic S, Malnar M, Chakraverty S, Goate AM, Bird TD, Leverenz JB. PMID: 21094210; PMCID: PMC3034479.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    43. Smoking enhances risk for new external genital warts in men. Int J Environ Res Public Health. 2009 03; 6(3):1215-34. Wiley DJ, Elashoff D, Masongsong EV, Harper DM, Gylys KH, Silverberg MJ, Cook RL, Johnson-Hill LM. PMID: 19440442; PMCID: PMC2672382.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    44. Biochemical markers in persons with preclinical familial Alzheimer disease. Neurology. 2008 Jul 08; 71(2):85-92. Ringman JM, Younkin SG, Pratico D, Seltzer W, Cole GM, Geschwind DH, Rodriguez-Agudelo Y, Schaffer B, Fein J, Sokolow S, Rosario ER, Gylys KH, Varpetian A, Medina LD, Cummings JL. PMID: 18509095.
      View in: PubMed   Mentions: 98     Fields:    Translation:Humans
    45. Co-localization of amyloid beta and tau pathology in Alzheimer's disease synaptosomes. Am J Pathol. 2008 Jun; 172(6):1683-92. Fein JA, Sokolow S, Miller CA, Vinters HV, Yang F, Cole GM, Gylys KH. PMID: 18467692; PMCID: PMC2408427.
      View in: PubMed   Mentions: 106     Fields:    Translation:HumansCells
    46. Smokers at higher risk for undetected antibody for oncogenic human papillomavirus type 16 infection. Cancer Epidemiol Biomarkers Prev. 2006 May; 15(5):915-20. Wiley DJ, Wiesmeier E, Masongsong E, Gylys KH, Koutsky LA, Ferris DG, Barr E, Yu Rao J, Proof of Principle Study Investigative Group. PMID: 16702370.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCellsCTClinical Trials
    47. Increased cholesterol in Abeta-positive nerve terminals from Alzheimer's disease cortex. Neurobiol Aging. 2007 Jan; 28(1):8-17. Gylys KH, Fein JA, Yang F, Miller CA, Cole GM. PMID: 16332401.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    48. Synaptic changes in Alzheimer's disease: increased amyloid-beta and gliosis in surviving terminals is accompanied by decreased PSD-95 fluorescence. Am J Pathol. 2004 Nov; 165(5):1809-17. Gylys KH, Fein JA, Yang F, Wiley DJ, Miller CA, Cole GM. PMID: 15509549; PMCID: PMC1618663.
      View in: PubMed   Mentions: 134     Fields:    Translation:HumansCells
    49. Enrichment of presynaptic and postsynaptic markers by size-based gating analysis of synaptosome preparations from rat and human cortex. Cytometry A. 2004 Jul; 60(1):90-6. Gylys KH, Fein JA, Yang F, Cole GM. PMID: 15229861.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    50. Rapid annexin-V labeling in synaptosomes. Neurochem Int. 2004 Feb; 44(3):125-31. Gylys KH, Fein JA, Wiley DJ, Cole GM. PMID: 14568554.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    51. Apolipoprotein E enhances uptake of soluble but not aggregated amyloid-beta protein into synaptic terminals. J Neurochem. 2003 Mar; 84(6):1442-51. Gylys KH, Fein JA, Tan AM, Cole GM. PMID: 12614344.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    52. Caspase inhibition protects nerve terminals from in vitro degradation. Neurochem Res. 2002 Jun; 27(6):465-72. Gylys KH, Fein JA, Cole GM. PMID: 12199150.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    53. Quantitative characterization of crude synaptosomal fraction (P-2) components by flow cytometry. J Neurosci Res. 2000 Jul 15; 61(2):186-92. Gylys KH, Fein JA, Cole GM. PMID: 10878591.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    54. Selectivity of hemicholinium mustard, an affinity ligand, for the high-affinity choline transport system. Neuropharmacology. 1997 Nov-Dec; 36(11-12):1741-6. Gylys KH, Abdalah I, Jenden DJ. PMID: 9517446.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    55. Regulation of acetylcholine synthesis in the presence of hemicholinium mustard. Life Sci. 1996; 58(22):1937-46. Gylys KH, Jenden DJ. PMID: 8637422.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    56. Characterization of the irreversible inhibition of high-affinity choline transport produced by hemicholinium mustard. J Neurochem. 1992 Oct; 59(4):1302-8. Gylys KH, Mellin C, Amstutz R, Jenden DJ. PMID: 1402882.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
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