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Jennifer Yokoyama, PhD

Title(s)Associate Professor, Neurology
SchoolSchool of Medicine
Address675 Nelson Rising Lane
San Francisco CA 94158
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    Other Positions
    Title(s)UCSF Weill Institute for Neurosciences


    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoPh.D.2010 Graduate Division (Pharmaceutical Sci & Pharmacogenomics)
    University of California, San Francisco, CA2019Diversity, Equity, and Inclusion Champion Training

    Collapse Overview 
    Collapse Overview
    Jennifer Yokoyama obtained her doctorate degree in Pharmaceutical Sciences and Pharmacogenomics from UCSF in December 2010 with Dr. Steven Hamilton (Department of Psychiatry and Institute for Human Genetics). Her dissertation comprised work within the Canine Behavioral Genetics Project, utilizing purebred dogs as genetic models for studying neuropsychiatric disease. Utilizing community-based canine DNA samples, Dr. Yokoyama performed genome-wide surveys for genetic loci underlying the canine anxiety disorder noise phobia, as well as for loci underlying adult-onset deafness in border collies.

    Dr. Yokoyama is currently an Assistant Professor at the Memory and Aging Center, where she is beginning a research program in neurogenetics of aging. Specifically, she is interested in the effect genotype can have on brain physiology, behavior and cognition in healthy older adults, and how this is related to increased vulnerability to (or protection from) neurodegenerative processes during aging. She is also particularly interested in understanding these effects in diverse ethnic populations. Dr. Yokoyama's long-term goal is to understand how variation across the entire genome confers risk for particular types of neurodegeneration for purposes of early treatment and therapeutic intervention.

    Collapse Research 
    Collapse Research Activities and Funding
    US-South American Initiative for Genetic-Neural-Behavioral Interactions in Human Neurodegenerative Research
    NIH/NIA R01AG057234Sep 30, 2019 - Mar 31, 2024
    Role: Co-Principal Investigator
    Elucidating clinical heterogeneity in early-onset AD via genomics, transcriptomics, and neuroimaging
    NIH/NIA R01AG062588Sep 15, 2019 - May 31, 2024
    Role: Principal Investigator
    Sex in Alzheimer disease
    NIH/NIA R03AG063260Apr 1, 2019 - Dec 31, 2020
    Role: Principal Investigator
    RNA signatures of frontotemporal dementia and ALS due to C9ORF72 expansion
    NIH/NIA K01AG049152Feb 1, 2015 - Jan 31, 2020
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. No association between the COMT Val158Met polymorphism and cognitive training response in healthy Shanghai community-dwelling elderly individuals. Ann Palliat Med. 2020 Jul 14. Feng W, Yu Z, Yu S, Wu W, Yokoyama JS, Li C. PMID: 32692209.
      View in: PubMed   Mentions:    Fields:    
    2. Non-coding and Loss-of-Function Coding Variants in TET2 are Associated with Multiple Neurodegenerative Diseases. Am J Hum Genet. 2020 May 07; 106(5):632-645. Cochran JN, Geier EG, Bonham LW, Newberry JS, Amaral MD, Thompson ML, Lasseigne BN, Karydas AM, Roberson ED, Cooper GM, Rabinovici GD, Miller BL, Myers RM, Yokoyama JS. PMID: 32330418.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    3. Longevity Gene KLOTHO and Alzheimer Disease-A Better Fate for Individuals Who Carry APOE e4. JAMA Neurol. 2020 Apr 13. Dubal DB, Yokoyama JS. PMID: 32282012.
      View in: PubMed   Mentions:    Fields:    
    4. Lack of Association Between the CCR5-delta32 Polymorphism and Neurodegenerative Disorders. Alzheimer Dis Assoc Disord. 2020 Jan 17. Wojta KJ, Ayer AH, Ramos EM, Nguyen PD, Karydas AM, Yokoyama JS, Kramer J, Lee SE, Boxer A, Miller BL, Coppola G. PMID: 31972607.
      View in: PubMed   Mentions:    Fields:    
    5. Genome sequencing for early-onset or atypical dementia: high diagnostic yield and frequent observation of multiple contributory alleles. Cold Spring Harb Mol Case Stud. 2019 12; 5(6). Cochran JN, McKinley EC, Cochran M, Amaral MD, Moyers BA, Lasseigne BN, Gray DE, Lawlor JMJ, Prokop JW, Geier EG, Holt JM, Thompson ML, Newberry JS, Yokoyama JS, Worthey EA, Geldmacher DS, Love MN, Cooper GM, Myers RM, Roberson ED. PMID: 31836585.
      View in: PubMed   Mentions: 2     Fields:    
    6. The Radiogenomics of Late-onset Alzheimer Disease. Top Magn Reson Imaging. 2019 Dec; 28(6):325-334. Bonham LW, Sirkis DW, Hess CP, Sugrue LP, Yokoyama JS. PMID: 31794505.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    7. Frequency of the TREM2 R47H Variant in Various Neurodegenerative Disorders. Alzheimer Dis Assoc Disord. 2019 Oct-Dec; 33(4):327-330. Ayer AH, Wojta K, Ramos EM, Dokuru D, Chen JA, Karydas AM, Papatriantafyllou JD, Agiomyrgiannakis D, Kamtsadeli V, Tsinia N, Sali D, Gylys KH, Agosta F, Filippi M, Small GW, Bennett DA, Gearing M, Juncos JL, Kramer J, Lee SE, Yokoyama JS, Mendez MF, Chui H, Zarow C, Ringman JM, Kilic U, Babacan-Yildiz G, Levey A, DeCarli CS, Cotman CW, Boxer AL, Miller BL, Coppola G. PMID: 31513029.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    8. Genetic variation across RNA metabolism and cell death gene networks is implicated in the semantic variant of primary progressive aphasia. Sci Rep. 2019 07 26; 9(1):10854. Bonham LW, Steele NZR, Karch CM, Broce I, Geier EG, Wen NL, Momeni P, Hardy J, Miller ZA, Gorno-Tempini ML, Hess CP, Lewis P, Miller BL, Seeley WW, Manzoni C, Desikan RS, Baranzini SE, Ferrari R, Yokoyama JS. PMID: 31350420.
      View in: PubMed   Mentions:    Fields:    
    9. Alzheimer Disease-associated Cortical Atrophy Does not Differ Between Chinese and Whites. Alzheimer Dis Assoc Disord. 2019 Jul-Sep; 33(3):186-193. Fan J, Tse M, Carr JS, Miller BL, Kramer JH, Rosen HJ, Bonham LW, Yokoyama JS. PMID: 31094707.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    10. The Transcriptional Landscape of Microglial Genes in Aging and Neurodegenerative Disease. Front Immunol. 2019; 10:1170. Bonham LW, Sirkis DW, Yokoyama JS. PMID: 31214167.
      View in: PubMed   Mentions: 1     Fields:    
    11. Immunological signatures in frontotemporal lobar degeneration. Curr Opin Neurol. 2019 04; 32(2):272-278. Sirkis DW, Bonham LW, Karch CM, Yokoyama JS. PMID: 30672824.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    12. Genetic origin of a large family with a novel PSEN1 mutation (Ile416Thr). Alzheimers Dement. 2019 05; 15(5):709-719. Ramirez Aguilar L, Acosta-Uribe J, Giraldo MM, Moreno S, Baena A, Alzate D, Cuastumal R, Aguillón D, Madrigal L, Saldarriaga A, Navarro A, Garcia GP, Aguirre-Acevedo DC, Geier EG, Cochran JN, Quiroz YT, Myers RM, Yokoyama JS, Kosik KS, Lopera F. PMID: 30745123.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    13. Genome-wide analyses as part of the international FTLD-TDP whole-genome sequencing consortium reveals novel disease risk factors and increases support for immune dysfunction in FTLD. Acta Neuropathol. 2019 06; 137(6):879-899. Pottier C, Ren Y, Perkerson RB, Baker M, Jenkins GD, van Blitterswijk M, DeJesus-Hernandez M, van Rooij JGJ, Murray ME, Christopher E, McDonnell SK, Fogarty Z, Batzler A, Tian S, Vicente CT, Matchett B, Karydas AM, Hsiung GR, Seelaar H, Mol MO, Finger EC, Graff C, Öijerstedt L, Neumann M, Heutink P, Synofzik M, Wilke C, Prudlo J, Rizzu P, Simon-Sanchez J, Edbauer D, Roeber S, Diehl-Schmid J, Evers BM, King A, Mesulam MM, Weintraub S, Geula C, Bieniek KF, Petrucelli L, Ahern GL, Reiman EM, Woodruff BK, Caselli RJ, Huey ED, Farlow MR, Grafman J, Mead S, Grinberg LT, Spina S, Grossman M, Irwin DJ, Lee EB, Suh E, Snowden J, Mann D, Ertekin-Taner N, Uitti RJ, Wszolek ZK, Josephs KA, Parisi JE, Knopman DS, Petersen RC, Hodges JR, Piguet O, Geier EG, Yokoyama JS, Rissman RA, Rogaeva E, Keith J, Zinman L, Tartaglia MC, Cairns NJ, Cruchaga C, Ghetti B, Kofler J, Lopez OL, Beach TG, Arzberger T, Herms J, Honig LS, Vonsattel JP, Halliday GM, Kwok JB, White CL, Gearing M, Glass J, Rollinson S, Pickering-Brown S, Rohrer JD, Trojanowski JQ, Van Deerlin V, Bigio EH, Troakes C, Al-Sarraj S, Asmann Y, Miller BL, Graff-Radford NR, Boeve BF, Seeley WW, Mackenzie IRA, van Swieten JC, Dickson DW, Biernacka JM, Rademakers R. PMID: 30739198.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    14. Polygenic hazard score, amyloid deposition and Alzheimer's neurodegeneration. Brain. 2019 02 01; 142(2):460-470. Tan CH, Bonham LW, Fan CC, Mormino EC, Sugrue LP, Broce IJ, Hess CP, Yokoyama JS, Rabinovici GD, Miller BL, Yaffe K, Schellenberg GD, Kauppi K, Holland D, McEvoy LK, Kukull WA, Tosun D, Weiner MW, Sperling RA, Bennett DA, Hyman BT, Andreassen OA, Dale AM, Desikan RS. PMID: 30689776.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    15. Recent advances in the genetics of frontotemporal dementia. Curr Genet Med Rep. 2019 Mar; 7(1):41-52. Sirkis DW, Geier EG, Bonham LW, Karch CM, Yokoyama JS. PMID: 31687268.
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    16. Dissecting the genetic relationship between cardiovascular risk factors and Alzheimer's disease. Acta Neuropathol. 2019 02; 137(2):209-226. Broce IJ, Tan CH, Fan CC, Jansen I, Savage JE, Witoelar A, Wen N, Hess CP, Dillon WP, Glastonbury CM, Glymour M, Yokoyama JS, Elahi FM, Rabinovici GD, Miller BL, Mormino EC, Sperling RA, Bennett DA, McEvoy LK, Brewer JB, Feldman HH, Hyman BT, Pericak-Vance M, Haines JL, Farrer LA, Mayeux R, Schellenberg GD, Yaffe K, Sugrue LP, Dale AM, Posthuma D, Andreassen OA, Karch CM, Desikan RS. PMID: 30413934.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    17. Rare variants in the neuronal ceroid lipofuscinosis gene MFSD8 are candidate risk factors for frontotemporal dementia. Acta Neuropathol. 2019 01; 137(1):71-88. Geier EG, Bourdenx M, Storm NJ, Cochran JN, Sirkis DW, Hwang JH, Bonham LW, Ramos EM, Diaz A, Van Berlo V, Dokuru D, Nana AL, Karydas A, Balestra ME, Huang Y, Russo SP, Spina S, Grinberg LT, Seeley WW, Myers RM, Miller BL, Coppola G, Lee SE, Cuervo AM, Yokoyama JS. PMID: 30382371.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    18. C9orf72-FTD/ALS pathogenesis: evidence from human neuropathological studies. Acta Neuropathol. 2019 01; 137(1):1-26. Vatsavayai SC, Nana AL, Yokoyama JS, Seeley WW. PMID: 30368547.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    19. Frequency of frontotemporal dementia gene variants in C9ORF72, MAPT, and GRN in academic versus commercial laboratory cohorts. Adv Genomics Genet. 2018; 8:23-33. Steele NZ, Bright AR, Lee SE, Fong JC, Bonham LW, Karydas A, Karbassi ID, Pribadi M, Meservey MA, Gallen MC, Ramos EM, Liaquat K, Hoffman CC, Krasner MR, Dodge W, L Miller B, Coppola G, Rankin KP, Yokoyama JS, Higgins JJ. PMID: 31031559.
      View in: PubMed   Mentions:
    20. Protein network analysis reveals selectively vulnerable regions and biological processes in FTD. Neurol Genet. 2018 Oct; 4(5):e266. Bonham LW, Steele NZR, Karch CM, Manzoni C, Geier EG, Wen N, Ofori-Kuragu A, Momeni P, Hardy J, Miller ZA, Hess CP, Lewis P, Miller BL, Seeley WW, Baranzini SE, Desikan RS, Ferrari R, Yokoyama JS. PMID: 30283816.
      View in: PubMed   Mentions:
    21. Regionally specific TSC1 and TSC2 gene expression in tuberous sclerosis complex. Sci Rep. 2018 09 06; 8(1):13373. Li Y, Barkovich MJ, Karch CM, Nillo RM, Fan CC, Broce IJ, Tan CH, Cuneo D, Hess CP, Dillon WP, Glenn OA, Glastonbury CM, Olney N, Yokoyama JS, Bonham LW, Miller B, Kao A, Schmansky N, Fischl B, Andreassen OA, Jernigan T, Dale A, Barkovich AJ, Desikan RS, Sugrue LP. PMID: 30190613.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    22. Joint genome-wide association study of progressive supranuclear palsy identifies novel susceptibility loci and genetic correlation to neurodegenerative diseases. Mol Neurodegener. 2018 08 08; 13(1):41. Chen JA, Chen Z, Won H, Huang AY, Lowe JK, Wojta K, Yokoyama JS, Bensimon G, Leigh PN, Payan C, Shatunov A, Jones AR, Lewis CM, Deloukas P, Amouyel P, Tzourio C, Dartigues JF, Ludolph A, Boxer AL, Bronstein JM, Al-Chalabi A, Geschwind DH, Coppola G. PMID: 30089514.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    23. Genetic Variation in the Androgen Receptor and Measures of Plasma Testosterone Levels Suggest Androgen Dysfunction in Alzheimer's Disease. Front Neurosci. 2018; 12:529. Carr JS, Bonham LW, Morgans AK, Ryan CJ, Yokoyama JS, Geier EG. PMID: 30131669.
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    24. Insulin-Like Growth Factor Binding Protein 2 Is Associated With Biomarkers of Alzheimer's Disease Pathology and Shows Differential Expression in Transgenic Mice. Front Neurosci. 2018; 12:476. Bonham LW, Geier EG, Steele NZR, Holland D, Miller BL, Dale AM, Desikan RS, Yokoyama JS. PMID: 30061810.
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    25. Selective Genetic Overlap Between Amyotrophic Lateral Sclerosis and Diseases of the Frontotemporal Dementia Spectrum. JAMA Neurol. 2018 07 01; 75(7):860-875. Karch CM, Wen N, Fan CC, Yokoyama JS, Kouri N, Ross OA, Höglinger G, Müller U, Ferrari R, Hardy J, Schellenberg GD, Sleiman PM, Momeni P, Hess CP, Miller BL, Sharma M, Van Deerlin V, Smeland OB, Andreassen OA, Dale AM, Desikan RS. PMID: 29630712.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    26. Prospects for observing and localizing gravitational-wave transients with Advanced LIGO, Advanced Virgo and KAGRA. Living Rev Relativ. 2018; 21(1):3. Abbott BP, Abbott R, Abbott TD, Abernathy MR, Acernese F, Ackley K, Adams C, Adams T, Addesso P, Adhikari RX, Adya VB, Affeldt C, Agathos M, Agatsuma K, Aggarwal N, Aguiar OD, Aiello L, Ain A, Ajith P, Akutsu T, Allen B, Allocca A, Altin PA, Ananyeva A, Anderson SB, Anderson WG, Ando M, Appert S, Arai K, Araya A, Araya MC, Areeda JS, Arnaud N, Arun KG, Asada H, Ascenzi S, Ashton G, Aso Y, Ast M, Aston SM, Astone P, Atsuta S, Aufmuth P, Aulbert C, Avila-Alvarez A, Awai K, Babak S, Bacon P, Bader MKM, Baiotti L, Baker PT, Baldaccini F, Ballardin G, Ballmer SW, Barayoga JC, Barclay SE, Barish BC, Barker D, Barone F, Barr B, Barsotti L, Barsuglia M, Barta D, Bartlett J, Barton MA, Bartos I, Bassiri R, Basti A, Batch JC, Baune C, Bavigadda V, Bazzan M, Bécsy B, Beer C, Bejger M, Belahcene I, Belgin M, Bell AS, Berger BK, Bergmann G, Berry CPL, Bersanetti D, Bertolini A, Betzwieser J, Bhagwat S, Bhandare R, Bilenko IA, Billingsley G, Billman CR, Birch J, Birney R, Birnholtz O, Biscans S, Bisht A, Bitossi M, Biwer C, Bizouard MA, Blackburn JK, Blackman J, Blair CD, Blair DG, Blair RM, Bloemen S, Bock O, Boer M, Bogaert G, Bohe A, Bondu F, Bonnand R, Boom BA, Bork R, Boschi V, Bose S, Bouffanais Y, Bozzi A, Bradaschia C, Brady PR, Braginsky VB, Branchesi M, Brau JE, Briant T, Brillet A, Brinkmann M, Brisson V, Brockill P, Broida JE, Brooks AF, Brown DA, Brown DD, Brown NM, Brunett S, Buchanan CC, Buikema A, Bulik T, Bulten HJ, Buonanno A, Buskulic D, Buy C, Byer RL, Cabero M, Cadonati L, Cagnoli G, Cahillane C, Calderón Bustillo J, Callister TA, Calloni E, Camp JB, Cannon KC, Cao H, Cao J, Capano CD, Capocasa E, Carbognani F, Caride S, Casanueva Diaz J, Casentini C, Caudill S, Cavaglià M, Cavalier F, Cavalieri R, Cella G, Cepeda CB, Cerboni Baiardi L, Cerretani G, Cesarini E, Chamberlin SJ, Chan M, Chao S, Charlton P, Chassande-Mottin E, Cheeseboro BD, Chen HY, Chen Y, Cheng HP, Chincarini A, Chiummo A, Chmiel T, Cho HS, Cho M, Chow JH, Christensen N, Chu Q, Chua AJK, Chua S, Chung S, Ciani G, Clara F, Clark JA, Cleva F, Cocchieri C, Coccia E, Cohadon PF, Colla A, Collette CG, Cominsky L, Constancio M, Conti L, Cooper SJ, Corbitt TR, Cornish N, Corsi A, Cortese S, Costa CA, Coughlin MW, Coughlin SB, Coulon JP, Countryman ST, Couvares P, Covas PB, Cowan EE, Coward DM, Cowart MJ, Coyne DC, Coyne R, Creighton JDE, Creighton TD, Cripe J, Crowder SG, Cullen TJ, Cumming A, Cunningham L, Cuoco E, Canton TD, Danilishin SL, D'Antonio S, Danzmann K, Dasgupta A, Da Silva Costa CF, Dattilo V, Dave I, Davier M, Davies GS, Davis D, Daw EJ, Day B, Day R, De S, DeBra D, Debreczeni G, Degallaix J, De Laurentis M, Deléglise S, Del Pozzo W, Denker T, Dent T, Dergachev V, De Rosa R, DeRosa RT, DeSalvo R, Devine RC, Dhurandhar S, Díaz MC, Fiore LD, Giovanni MD, Girolamo TD, Lieto AD, Pace SD, Palma ID, Virgilio AD, Doctor Z, Doi K, Dolique V, Donovan F, Dooley KL, Doravari S, Dorrington I, Douglas R, Dovale Álvarez M, Downes TP, Drago M, Drever RWP, Driggers JC, Du Z, Ducrot M, Dwyer SE, Eda K, Edo TB, Edwards MC, Effler A, Eggenstein HB, Ehrens P, Eichholz J, Eikenberry SS, Eisenstein RA, Essick RC, Etienne Z, Etzel T, Evans M, Evans TM, Everett R, Factourovich M, Fafone V, Fair H, Fairhurst S, Fan X, Farinon S, Farr B, Farr WM, Fauchon-Jones EJ, Favata M, Fays M, Fehrmann H, Fejer MM, Fernández Galiana A, Ferrante I, Ferreira EC, Ferrini F, Fidecaro F, Fiori I, Fiorucci D, Fisher RP, Flaminio R, Fletcher M, Fong H, Forsyth SS, Fournier JD, Frasca S, Frasconi F, Frei Z, Freise A, Frey R, Frey V, Fries EM, Fritschel P, Frolov VV, Fujii Y, Fujimoto MK, Fulda P, Fyffe M, Gabbard H, Gadre BU, Gaebel SM, Gair JR, Gammaitoni L, Gaonkar SG, Garufi F, Gaur G, Gayathri V, Gehrels N, Gemme G, Genin E, Gennai A, George J, Gergely L, Germain V, Ghonge S, Ghosh A, Ghosh A, Ghosh S, Giaime JA, Giardina KD, Giazotto A, Gill K, Glaefke A, Goetz E, Goetz R, Gondan L, González G, Gonzalez Castro JM, Gopakumar A, Gorodetsky ML, Gossan SE, Gosselin M, Gouaty R, et al. PMID: 29725242.
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    27. CXCR4 involvement in neurodegenerative diseases. Transl Psychiatry. 2018 04 11; 8(1):73. Bonham LW, Karch CM, Fan CC, Tan C, Geier EG, Wang Y, Wen N, Broce IJ, Li Y, Barkovich MJ, Ferrari R, Hardy J, Momeni P, Höglinger G, Müller U, Hess CP, Sugrue LP, Dillon WP, Schellenberg GD, Miller BL, Andreassen OA, Dale AM, Barkovich AJ, Yokoyama JS, Desikan RS. PMID: 29636460.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    28. Correction: Immune-related genetic enrichment in frontotemporal dementia: An analysis of genome-wide association studies. PLoS Med. 2018 01; 15(1):e1002504. Broce I, Karch CM, Wen N, Fan CC, Wang Y, Tan CH, Kouri N, Ross OA, Höglinger GU, Muller U, Hardy J, Momeni P, Hess CP, Dillon WP, Miller ZA, Bonham LW, Rabinovici GD, Rosen HJ, Schellenberg GD, Franke A, Karlsen TH, Veldink JH, Ferrari R, Yokoyama JS, Miller BL, Andreassen OA, Dale AM, Desikan RS, Sugrue LP. PMID: 29377952.
      View in: PubMed   Mentions: 1     Fields:    
    29. Neurotransmitter Pathway Genes in Cognitive Decline During Aging: Evidence for GNG4 and KCNQ2 Genes. Am J Alzheimers Dis Other Demen. 2018 05; 33(3):153-165. Bonham LW, Evans DS, Liu Y, Cummings SR, Yaffe K, Yokoyama JS. PMID: 29338302.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    30. Immune-related genetic enrichment in frontotemporal dementia: An analysis of genome-wide association studies. PLoS Med. 2018 01; 15(1):e1002487. Broce I, Karch CM, Wen N, Fan CC, Wang Y, Tan CH, Kouri N, Ross OA, Höglinger GU, Muller U, Hardy J, Momeni P, Hess CP, Dillon WP, Miller ZA, Bonham LW, Rabinovici GD, Rosen HJ, Schellenberg GD, Franke A, Karlsen TH, Veldink JH, Ferrari R, Yokoyama JS, Miller BL, Andreassen OA, Dale AM, Desikan RS, Sugrue LP. PMID: 29315334.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    31. Polygenic hazard score: an enrichment marker for Alzheimer's associated amyloid and tau deposition. Acta Neuropathol. 2018 01; 135(1):85-93. Tan CH, Fan CC, Mormino EC, Sugrue LP, Broce IJ, Hess CP, Dillon WP, Bonham LW, Yokoyama JS, Karch CM, Brewer JB, Rabinovici GD, Miller BL, Schellenberg GD, Kauppi K, Feldman HA, Holland D, McEvoy LK, Hyman BT, Bennett DA, Andreassen OA, Dale AM, Desikan RS. PMID: 29177679.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    32. Systemic klotho is associated with KLOTHO variation and predicts intrinsic cortical connectivity in healthy human aging. Brain Imaging Behav. 2017 04; 11(2):391-400. Yokoyama JS, Marx G, Brown JA, Bonham LW, Wang D, Coppola G, Seeley WW, Rosen HJ, Miller BL, Kramer JH, Dubal DB. PMID: 27714549.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    33. Fine-mapping of the human leukocyte antigen locus as a risk factor for Alzheimer disease: A case-control study. PLoS Med. 2017 Mar; 14(3):e1002272. Steele NZ, Carr JS, Bonham LW, Geier EG, Damotte V, Miller ZA, Desikan RS, Boehme KL, Mukherjee S, Crane PK, Kauwe JS, Kramer JH, Miller BL, Coppola G, Hollenbach JA, Huang Y, Yokoyama JS. PMID: 28350795.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    34. Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score. PLoS Med. 2017 03; 14(3):e1002258. Desikan RS, Fan CC, Wang Y, Schork AJ, Cabral HJ, Cupples LA, Thompson WK, Besser L, Kukull WA, Holland D, Chen CH, Brewer JB, Karow DS, Kauppi K, Witoelar A, Karch CM, Bonham LW, Yokoyama JS, Rosen HJ, Miller BL, Dillon WP, Wilson DM, Hess CP, Pericak-Vance M, Haines JL, Farrer LA, Mayeux R, Hardy J, Goate AM, Hyman BT, Schellenberg GD, McEvoy LK, Andreassen OA, Dale AM. PMID: 28323831.
      View in: PubMed   Mentions: 44     Fields:    Translation:Humans
    35. Youthful Processing Speed in Older Adults: Genetic, Biological, and Behavioral Predictors of Cognitive Processing Speed Trajectories in Aging. Front Aging Neurosci. 2017; 9:55. Bott NT, Bettcher BM, Yokoyama JS, Frazier DT, Wynn M, Karydas A, Yaffe K, Kramer JH. PMID: 28344553.
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    36. Shared genetic risk between corticobasal degeneration, progressive supranuclear palsy, and frontotemporal dementia. Acta Neuropathol. 2017 05; 133(5):825-837. Yokoyama JS, Karch CM, Fan CC, Bonham LW, Kouri N, Ross OA, Rademakers R, Kim J, Wang Y, Höglinger GU, Müller U, Ferrari R, Hardy J, Momeni P, Sugrue LP, Hess CP, James Barkovich A, Boxer AL, Seeley WW, Rabinovici GD, Rosen HJ, Miller BL, Schmansky NJ, Fischl B, Hyman BT, Dickson DW, Schellenberg GD, Andreassen OA, Dale AM, Desikan RS. PMID: 28271184.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    37. Identification of a rare coding variant in TREM2 in a Chinese individual with Alzheimer's disease. Neurocase. 2017 Feb; 23(1):65-69. Bonham LW, Sirkis DW, Fan J, Aparicio RE, Tse M, Ramos EM, Wang Q, Coppola G, Rosen HJ, Miller BL, Yokoyama JS. PMID: 28376694.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    38. Genome-wide association study identifies MAPT locus influencing human plasma tau levels. Neurology. 2017 Feb 14; 88(7):669-676. Chen J, Yu JT, Wojta K, Wang HF, Zetterberg H, Blennow K, Yokoyama JS, Weiner MW, Kramer JH, Rosen H, Miller BL, Coppola G, Boxer AL. PMID: 28100725.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    39. Genetic architecture of sporadic frontotemporal dementia and overlap with Alzheimer's and Parkinson's diseases. J Neurol Neurosurg Psychiatry. 2017 02; 88(2):152-164. Ferrari R, Wang Y, Vandrovcova J, Guelfi S, Witeolar A, Karch CM, Schork AJ, Fan CC, Brewer JB, Momeni P, Schellenberg GD, Dillon WP, Sugrue LP, Hess CP, Yokoyama JS, Bonham LW, Rabinovici GD, Miller BL, Andreassen OA, Dale AM, Hardy J, Desikan RS. PMID: 27899424.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    40. Increased prevalence of autoimmune disease within C9 and FTD/MND cohorts: Completing the picture. Neurol Neuroimmunol Neuroinflamm. 2016 Dec; 3(6):e301. Miller ZA, Sturm VE, Camsari GB, Karydas A, Yokoyama JS, Grinberg LT, Boxer AL, Rosen HJ, Rankin KP, Gorno-Tempini ML, Coppola G, Geschwind DH, Rademakers R, Seeley WW, Graff-Radford NR, Miller BL. PMID: 27844039.
      View in: PubMed   Mentions: 11     Fields:    
    41. Association of Alzheimer Disease Susceptibility Variants and Gene Expression in the Human Brain-Reply. JAMA Neurol. 2016 10 01; 73(10):1255. Yokoyama JS, Desikan RS. PMID: 27532297.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    42. Rare TREM2 variants associated with Alzheimer's disease display reduced cell surface expression. Acta Neuropathol Commun. 2016 09 02; 4(1):98. Sirkis DW, Bonham LW, Aparicio RE, Geier EG, Ramos EM, Wang Q, Karydas A, Miller ZA, Miller BL, Coppola G, Yokoyama JS. PMID: 27589997.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    43. Age-dependent effects of APOE e4 in preclinical Alzheimer's disease. Ann Clin Transl Neurol. 2016 Sep; 3(9):668-77. Bonham LW, Geier EG, Fan CC, Leong JK, Besser L, Kukull WA, Kornak J, Andreassen OA, Schellenberg GD, Rosen HJ, Dillon WP, Hess CP, Miller BL, Dale AM, Desikan RS, Yokoyama JS. PMID: 27648456.
      View in: PubMed   Mentions: 8     Fields:    
    44. The relationship between complement factor C3, APOE e4, amyloid and tau in Alzheimer's disease. Acta Neuropathol Commun. 2016 06 29; 4(1):65. Bonham LW, Desikan RS, Yokoyama JS. PMID: 27357286.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    45. Association Between Genetic Traits for Immune-Mediated Diseases and Alzheimer Disease. JAMA Neurol. 2016 06 01; 73(6):691-7. Yokoyama JS, Wang Y, Schork AJ, Thompson WK, Karch CM, Cruchaga C, McEvoy LK, Witoelar A, Chen CH, Holland D, Brewer JB, Franke A, Dillon WP, Wilson DM, Mukherjee P, Hess CP, Miller Z, Bonham LW, Shen J, Rabinovici GD, Rosen HJ, Miller BL, Hyman BT, Schellenberg GD, Karlsen TH, Andreassen OA, Dale AM, Desikan RS. PMID: 27088644.
      View in: PubMed   Mentions: 34     Fields:    Translation:Humans
    46. Gene-based aggregate SNP associations between candidate AD genes and cognitive decline. Age (Dordr). 2016 Apr; 38(2):41. Nettiksimmons J, Tranah G, Evans DS, Yokoyama JS, Yaffe K. PMID: 27005436.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    47. The 5-HTTLPR variant in the serotonin transporter gene modifies degeneration of brain regions important for emotion in behavioral variant frontotemporal dementia. Neuroimage Clin. 2015; 9:283-90. Yokoyama JS, Bonham LW, Sturm VE, Adhimoolam B, Karydas A, Coppola G, Miller BL, Rankin KP. PMID: 26509115.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    48. Amyloid in dementia associated with familial FTLD: not an innocent bystander. Neurocase. 2016; 22(1):76-83. Naasan G, Rabinovici GD, Ghosh P, Elofson JD, Miller BL, Coppola G, Karydas A, Fong J, Perry D, Lee SE, Yokoyama JS, Seeley WW, Kramer JH, Weiner MW, Schuff N, Jagust WJ, Grinberg LT, Pribadi M, Yang Z, Sears R, Klein E, Wojta K, Rosen HJ. PMID: 26040468.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    49. Decision tree analysis of genetic risk for clinically heterogeneous Alzheimer's disease. BMC Neurol. 2015 Mar 28; 15:47. Yokoyama JS, Bonham LW, Sears RL, Klein E, Karydas A, Kramer JH, Miller BL, Coppola G. PMID: 25880661.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    50. Apolipoprotein e4 is associated with lower brain volume in cognitively normal Chinese but not white older adults. PLoS One. 2015; 10(3):e0118338. Yokoyama JS, Lee AK, Takada LT, Busovaca E, Bonham LW, Chao SZ, Tse M, He J, Schwarz CG, Carmichael OT, Matthews BR, Karydas A, Weiner MW, Coppola G, DeCarli CS, Miller BL, Rosen HJ. PMID: 25738563.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    51. Variation in longevity gene KLOTHO is associated with greater cortical volumes. Ann Clin Transl Neurol. 2015 Mar; 2(3):215-30. Yokoyama JS, Sturm VE, Bonham LW, Klein E, Arfanakis K, Yu L, Coppola G, Kramer JH, Bennett DA, Miller BL, Dubal DB. PMID: 25815349.
      View in: PubMed   Mentions: 20     Fields:    
    52. APOE Genotype Affects Cognitive Training Response in Healthy Shanghai Community-Dwelling Elderly Individuals. J Alzheimers Dis. 2015; 47(4):1035-46. Feng W, Yokoyama JS, Yu S, Chen Y, Cheng Y, Bonham LW, Wang D, Shen Y, Wu W, Li C. PMID: 26401781.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    53. Damage to left frontal regulatory circuits produces greater positive emotional reactivity in frontotemporal dementia. Cortex. 2015 Mar; 64:55-67. Sturm VE, Yokoyama JS, Eckart JA, Zakrzewski J, Rosen HJ, Miller BL, Seeley WW, Levenson RW. PMID: 25461707.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    54. Altered network connectivity in frontotemporal dementia with C9orf72 hexanucleotide repeat expansion. Brain. 2014 Nov; 137(Pt 11):3047-60. Lee SE, Khazenzon AM, Trujillo AJ, Guo CC, Yokoyama JS, Sha SJ, Takada LT, Karydas AM, Block NR, Coppola G, Pribadi M, Geschwind DH, Rademakers R, Fong JC, Weiner MW, Boxer AL, Kramer JH, Rosen HJ, Miller BL, Seeley WW. PMID: 25273996.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    55. The Chinese Verbal Learning Test specifically assesses hippocampal state. Am J Alzheimers Dis Other Demen. 2015 Jun; 30(4):412-6. Tsai RM, Leong JK, Dutt S, Chang CC, Lee AK, Chao SZ, Yokoyama JS, Tse M, Kramer JH, Miller BL, Rosen HJ. PMID: 25270640.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    56. Life extension factor klotho enhances cognition. Cell Rep. 2014 May 22; 7(4):1065-76. Dubal DB, Yokoyama JS, Zhu L, Broestl L, Worden K, Wang D, Sturm VE, Kim D, Klein E, Yu GQ, Ho K, Eilertson KE, Yu L, Kuro-o M, De Jager PL, Coppola G, Small GW, Bennett DA, Kramer JH, Abraham CR, Miller BL, Mucke L. PMID: 24813892.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansAnimalsCells
    57. C9ORF72 hexanucleotide repeats in behavioral and motor neuron disease: clinical heterogeneity and pathological diversity. Am J Neurodegener Dis. 2014; 3(1):1-18. Yokoyama JS, Sirkis DW, Miller BL. PMID: 24753999.
      View in: PubMed   Mentions:
    58. Genetic modifiers of cognitive maintenance among older adults. Hum Brain Mapp. 2014 Sep; 35(9):4556-65. Yokoyama JS, Evans DS, Coppola G, Kramer JH, Tranah GJ, Yaffe K. PMID: 24616004.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    59. Mitochondrial DNA sequence associations with dementia and amyloid-ß in elderly African Americans. Neurobiol Aging. 2014 Feb; 35(2):442.e1-8. Tranah GJ, Yokoyama JS, Katzman SM, Nalls MA, Newman AB, Harris TB, Cesari M, Manini TM, Schork NJ, Cummings SR, Liu Y, Yaffe K. PMID: 24140124.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    60. Depressive symptoms in Chinese-American subjects with cognitive impairment. Am J Geriatr Psychiatry. 2014 Jul; 22(7):642-52. Chao SZ, Matthews BR, Yokoyama JS, Lai NB, Ong H, Tse M, Yuan RF, Lin A, Kramer J, Yaffe K, Kornak J, Miller BL, Rosen HJ. PMID: 24021225.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    61. Progranulin mutations as risk factors for Alzheimer disease. JAMA Neurol. 2013 Jun; 70(6):774-8. Perry DC, Lehmann M, Yokoyama JS, Karydas A, Lee JJ, Coppola G, Grinberg LT, Geschwind D, Seeley WW, Miller BL, Rosen H, Rabinovici G. PMID: 23609919.
      View in: PubMed   Mentions: 30     Fields:    Translation:Humans
    62. Heightened emotional contagion in mild cognitive impairment and Alzheimer's disease is associated with temporal lobe degeneration. Proc Natl Acad Sci U S A. 2013 Jun 11; 110(24):9944-9. Sturm VE, Yokoyama JS, Seeley WW, Kramer JH, Miller BL, Rankin KP. PMID: 23716653.
      View in: PubMed   Mentions: 37     Fields:    Translation:Humans
    63. Neuroimaging features of C9ORF72 expansion. Alzheimers Res Ther. 2012; 4(6):45. Yokoyama JS, Rosen HJ. PMID: 23153366.
      View in: PubMed   Mentions: 5     Fields:    
    64. Variation in genes related to cochlear biology is strongly associated with adult-onset deafness in border collies. PLoS Genet. 2012 Sep; 8(9):e1002898. Yokoyama JS, Lam ET, Ruhe AL, Erdman CA, Robertson KR, Webb AA, Williams DC, Chang ML, Hytönen MK, Lohi H, Hamilton SP, Neff MW. PMID: 23028339.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    65. Frontotemporal dementia in a Brazilian kindred with the c9orf72 mutation. Arch Neurol. 2012 Sep; 69(9):1149-53. Takada LT, Pimentel ML, Dejesus-Hernandez M, Fong JC, Yokoyama JS, Karydas A, Thibodeau MP, Rutherford NJ, Baker MC, Lomen-Hoerth C, Rademakers R, Miller BL. PMID: 22964910.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    66. Frontotemporal dementia due to C9ORF72 mutations: clinical and imaging features. Neurology. 2012 Sep 04; 79(10):1002-11. Sha SJ, Takada LT, Rankin KP, Yokoyama JS, Rutherford NJ, Fong JC, Khan B, Karydas A, Baker MC, DeJesus-Hernandez M, Pribadi M, Coppola G, Geschwind DH, Rademakers R, Lee SE, Seeley W, Miller BL, Boxer AL. PMID: 22875087.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansCells
    67. Mitochondrial DNA sequence variation is associated with free-living activity energy expenditure in the elderly. Biochim Biophys Acta. 2012 Sep; 1817(9):1691-700. Tranah GJ, Lam ET, Katzman SM, Nalls MA, Zhao Y, Evans DS, Yokoyama JS, Pawlikowska L, Kwok PY, Mooney S, Kritchevsky S, Goodpaster BH, Newman AB, Harris TB, Manini TM, Cummings SR. PMID: 22659402.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    68. Atypical, slowly progressive behavioural variant frontotemporal dementia associated with C9ORF72 hexanucleotide expansion. J Neurol Neurosurg Psychiatry. 2012 Apr; 83(4):358-64. Khan BK, Yokoyama JS, Takada LT, Sha SJ, Rutherford NJ, Fong JC, Karydas AM, Wu T, Ketelle RS, Baker MC, Hernandez MD, Coppola G, Geschwind DH, Rademakers R, Lee SE, Rosen HJ, Rabinovici GD, Seeley WW, Rankin KP, Boxer AL, Miller BL. PMID: 22399793.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansCells
    69. Mitochondrial DNA sequence variation associated with dementia and cognitive function in the elderly. J Alzheimers Dis. 2012; 32(2):357-72. Tranah GJ, Nalls MA, Katzman SM, Yokoyama JS, Lam ET, Zhao Y, Mooney S, Thomas F, Newman AB, Liu Y, Cummings SR, Harris TB, Yaffe K. PMID: 22785396.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    70. Array-based whole-genome survey of dog saliva DNA yields high quality SNP data. PLoS One. 2010 May 25; 5(5):e10809. Yokoyama JS, Erdman CA, Hamilton SP. PMID: 20520842.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    71. A genomewide association study of citalopram response in major depressive disorder. Biol Psychiatry. 2010 Jan 15; 67(2):133-8. Garriock HA, Kraft JB, Shyn SI, Peters EJ, Yokoyama JS, Jenkins GD, Reinalda MS, Slager SL, McGrath PJ, Hamilton SP. PMID: 19846067.
      View in: PubMed   Mentions: 105     Fields:    Translation:Humans
    72. Novel loci for major depression identified by genome-wide association study of Sequenced Treatment Alternatives to Relieve Depression and meta-analysis of three studies. Mol Psychiatry. 2011 Feb; 16(2):202-15. Shyn SI, Shi J, Kraft JB, Potash JB, Knowles JA, Weissman MM, Garriock HA, Yokoyama JS, McGrath PJ, Peters EJ, Scheftner WA, Coryell W, Lawson WB, Jancic D, Gejman PV, Sanders AR, Holmans P, Slager SL, Levinson DF, Hamilton SP. PMID: 20038947.
      View in: PubMed   Mentions: 96     Fields:    Translation:Humans
    73. Antitumor therapy mediated by 5-fluorocytosine and a recombinant fusion protein containing TSG-6 hyaluronan binding domain and yeast cytosine deaminase. Mol Pharm. 2009 May-Jun; 6(3):801-12. Park JI, Cao L, Platt VM, Huang Z, Stull RA, Dy EE, Sperinde JJ, Yokoyama JS, Szoka FC. PMID: 19265397.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    74. Activation of cerebellar parallel fibers monitored in transgenic mice expressing a fluorescent Ca2+ indicator protein. Eur J Neurosci. 2005 Aug; 22(3):627-35. Díez-García J, Matsushita S, Mutoh H, Nakai J, Ohkura M, Yokoyama J, Dimitrov D, Knöpfel T. PMID: 16101744.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
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