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Identification and biological characterization of 6-aryl-7-isopropylquinazolinones as novel TRPV1 antagonists that are effective in models of chronic pain. J Med Chem. 2006 Jan 26; 49(2):471-4.
Culshaw AJ, Bevan S, Christiansen M, Copp P, Davis A, Davis C, Dyson A, Dziadulewicz EK, Edwards L, Eggelte H, Fox A, Gentry C, Groarke A, Hallett A, Hart TW, Hughes GA, Knights S, Kotsonis P, Lee W, Lyothier I, McBryde A, McIntyre P, Paloumbis G, Panesar M, Patel S, Seiler MP, Yaqoob M, Zimmermann K. PMID: 16420034.
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17 Fields:
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HumansAnimalsCells
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Structural analysis of isoform-specific inhibitors targeting the tetrahydrobiopterin binding site of human nitric oxide synthases. J Med Chem. 2005 Jul 28; 48(15):4783-92.
Matter H, Kumar HS, Fedorov R, Frey A, Kotsonis P, Hartmann E, Fröhlich LG, Reif A, Pfleiderer W, Scheurer P, Ghosh DK, Schlichting I, Schmidt HH. PMID: 16033258.
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12 Fields:
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HumansAnimalsCells
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Vanilloid receptor TRPV1, sensory C-fibers, and vascular autoregulation: a novel mechanism involved in myogenic constriction. Circ Res. 2004 Nov 12; 95(10):1027-34.
Scotland RS, Chauhan S, Davis C, De Felipe C, Hunt S, Kabir J, Kotsonis P, Oh U, Ahluwalia A. PMID: 15499026.
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56 Fields:
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AnimalsCells
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Biology and Chemistry of the Inhibition of Nitric Oxide Synthases by Pteridine-Derivatives as Therapeutic Agents. ChemInform. 2004 Oct 19; 35(42).
Matter MH, Kotsonis KP. .
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Biology and chemistry of the inhibition of nitric oxide synthases by pteridine-derivatives as therapeutic agents. Med Res Rev. 2004 Sep; 24(5):662-84.
Matter H, Kotsonis P. PMID: 15224385.
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3 Fields:
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HumansAnimalsCells
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N-Formyl peptide receptor subtypes in human neutrophils activate L-plastin phosphorylation through different signal transduction intermediates. Biochem J. 2004 Jan 15; 377(Pt 2):469-77.
Paclet MH, Davis C, Kotsonis P, Godovac-Zimmermann J, Segal AW, Dekker LV. PMID: 14556648; PMCID: PMC1223878.
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10 Fields:
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HumansCells
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Cloning and functional characterization of the guinea pig vanilloid receptor 1. Neuropharmacology. 2002 Sep; 43(3):450-6.
Savidge J, Davis C, Shah K, Colley S, Phillips E, Ranasinghe S, Winter J, Kotsonis P, Rang H, McIntyre P. PMID: 12243775.
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21 Fields:
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AnimalsCells
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Structural requirements for inhibition of the neuronal nitric oxide synthase (NOS-I): 3D-QSAR analysis of 4-oxo- and 4-amino-pteridine-based inhibitors. J Med Chem. 2002 Jul 04; 45(14):2923-41.
Matter H, Kotsonis P, Klingler O, Strobel H, Fröhlich LG, Frey A, Pfleiderer W, Schmidt HH. PMID: 12086480.
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7 Fields:
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Cells
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Life Sci. Modulation of acetylcholine release from mouse cortex by protein kinase C: dependence on stimulation intensity.
. 2000; 1(67):31-8.
Iannazzo L, Kotsonis P, Majewski H.
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Allosteric regulation of neuronal nitric oxide synthase by tetrahydrobiopterin and suppression of auto-damaging superoxide. Biochemical Journal. 2000 Mar 15; 346(3):767-776.
KOTSONIS KP, FRÖHLICH FL, SHUTENKO SZ, HOREJSI HR, PFLEIDERER PW, SCHMIDT SH. .
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Eur J Pharmacol. Structural determinants of phorbol ester binding in synaptosomes: pharmacokinetics and pharmacodynamics.
. 1999; 1(381):77-84.
Murphy TV, Prountzos C, Kotsonis P, Iannazzo L, Majewski H.
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Autoinhibition of neuronal nitric oxide synthase: distinct effects of reactive nitrogen and oxygen species on enzyme activity. Biochemical Journal. 1999 Jun 15; 340(3):745-752.
KOTSONIS KP, Armin AF, FRÖHLICH FL, HOFMANN HH, Andreas AR, WINK WD, FEELISCH FM, SCHMIDT SH. .
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Br J Pharmacol. The structural requirements for phorbol esters to enhance serotonin and acetylcholine release from rat brain cortex.
. 1999; 5(127):1177-89.
Iannazzo L, Kotsonis P, Majewski H.
.