Peter Kotsonis, PhD

SchoolUCSF Chancellor/EVC/FAS
DepartmentInnovation Ventures
Address600 16th St
San Francisco CA 94158
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Culshaw AJ, Bevan S, Christiansen M, Copp P, Davis A, Davis C, Dyson A, Dziadulewicz EK, Edwards L, Eggelte H, Fox A, Gentry C, Groarke A, Hallett A, Hart TW, Hughes GA, Knights S, Kotsonis P, Lee W, Lyothier I, McBryde A, McIntyre P, Paloumbis G, Panesar M, Patel S, Seiler MP, Yaqoob M, Zimmermann K. Identification and biological characterization of 6-aryl-7-isopropylquinazolinones as novel TRPV1 antagonists that are effective in models of chronic pain. J Med Chem. 2006 Jan 26; 49(2):471-4. PMID: 16420034.
      View in: PubMed
    2. Matter H, Kumar HS, Fedorov R, Frey A, Kotsonis P, Hartmann E, Fröhlich LG, Reif A, Pfleiderer W, Scheurer P, Ghosh DK, Schlichting I, Schmidt HH. Structural analysis of isoform-specific inhibitors targeting the tetrahydrobiopterin binding site of human nitric oxide synthases. J Med Chem. 2005 Jul 28; 48(15):4783-92. PMID: 16033258.
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    3. Scotland RS, Chauhan S, Davis C, De Felipe C, Hunt S, Kabir J, Kotsonis P, Oh U, Ahluwalia A. Vanilloid receptor TRPV1, sensory C-fibers, and vascular autoregulation: a novel mechanism involved in myogenic constriction. Circ Res. 2004 Nov 12; 95(10):1027-34. PMID: 15499026.
      View in: PubMed
    4. Matter H, Kotsonis P. Biology and chemistry of the inhibition of nitric oxide synthases by pteridine-derivatives as therapeutic agents. Med Res Rev. 2004 Sep; 24(5):662-84. PMID: 15224385.
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    5. Paclet MH, Davis C, Kotsonis P, Godovac-Zimmermann J, Segal AW, Dekker LV. N-Formyl peptide receptor subtypes in human neutrophils activate L-plastin phosphorylation through different signal transduction intermediates. Biochem J. 2004 Jan 15; 377(Pt 2):469-77. PMID: 14556648; PMCID: PMC1223878.
    6. Savidge J, Davis C, Shah K, Colley S, Phillips E, Ranasinghe S, Winter J, Kotsonis P, Rang H, McIntyre P. Cloning and functional characterization of the guinea pig vanilloid receptor 1. Neuropharmacology. 2002 Sep; 43(3):450-6. PMID: 12243775.
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    7. Matter H, Kotsonis P, Klingler O, Strobel H, Fröhlich LG, Frey A, Pfleiderer W, Schmidt HH. Structural requirements for inhibition of the neuronal nitric oxide synthase (NOS-I): 3D-QSAR analysis of 4-oxo- and 4-amino-pteridine-based inhibitors. J Med Chem. 2002 Jul 04; 45(14):2923-41. PMID: 12086480.
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    8. Kotsonis P, Fröhlich LG, Raman CS, Li H, Berg M, Gerwig R, Groehn V, Kang Y, Al-Masoudi N, Taghavi-Moghadam S, Mohr D, Münch U, Schnabel J, Martásek P, Masters BS, Strobel H, Poulos T, Matter H, Pfleiderer W, Schmidt HH. Structural basis for pterin antagonism in nitric-oxide synthase. Development of novel 4-oxo-pteridine antagonists of (6R)-5,6,7,8-tetrahydrobiopterin. J Biol Chem. 2001 Dec 28; 276(52):49133-41. PMID: 11590164.
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    9. Kotsonis P, Funk L, Prountzos C, Iannazzo L, Majewski H. Differential abilities of phorbol esters in inducing protein kinase C (PKC) down-regulation in noradrenergic neurones. Br J Pharmacol. 2001 Jan; 132(2):489-99. PMID: 11159699; PMCID: PMC1572566.
    10. Iannazzo L, Kotsonis P, Majewski H. . Life Sci. Modulation of acetylcholine release from mouse cortex by protein kinase C: dependence on stimulation intensity. . 2000; 1(67):31-8.
    11. Kotsonis P, Fröhlich LG, Shutenko ZV, Horejsi R, Pfleiderer W, Schmidt HH. Allosteric regulation of neuronal nitric oxide synthase by tetrahydrobiopterin and suppression of auto-damaging superoxide. Biochem J. 2000 Mar 15; 346 Pt 3:767-76. PMID: 10698705; PMCID: PMC1220911.
    12. Butt E, Bernhardt M, Smolenski A, Kotsonis P, Fröhlich LG, Sickmann A, Meyer HE, Lohmann SM, Schmidt HH. Endothelial nitric-oxide synthase (type III) is activated and becomes calcium independent upon phosphorylation by cyclic nucleotide-dependent protein kinases. J Biol Chem. 2000 Feb 18; 275(7):5179-87. PMID: 10671564.
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    13. Fröhlich LG, Kotsonis P, Traub H, Taghavi-Moghadam S, Al-Masoudi N, Hofmann H, Strobel H, Matter H, Pfleiderer W, Schmidt HH. Inhibition of neuronal nitric oxide synthase by 4-amino pteridine derivatives: structure-activity relationship of antagonists of (6R)-5,6,7,8-tetrahydrobiopterin cofactor. J Med Chem. 1999 Oct 07; 42(20):4108-21. PMID: 10514281.
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    14. Murphy TV, Prountzos C, Kotsonis P, Iannazzo L, Majewski H. . Eur J Pharmacol. Structural determinants of phorbol ester binding in synaptosomes: pharmacokinetics and pharmacodynamics. . 1999; 1(381):77-84.
    15. Reif A, Fröhlich LG, Kotsonis P, Frey A, Bömmel HM, Wink DA, Pfleiderer W, Schmidt HH. Tetrahydrobiopterin inhibits monomerization and is consumed during catalysis in neuronal NO synthase. J Biol Chem. 1999 Aug 27; 274(35):24921-9. PMID: 10455167.
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    16. Feelisch M, Kotsonis P, Siebe J, Clement B, Schmidt HH. The soluble guanylyl cyclase inhibitor 1H-[1,2,4]oxadiazolo[4,3,-a] quinoxalin-1-one is a nonselective heme protein inhibitor of nitric oxide synthase and other cytochrome P-450 enzymes involved in nitric oxide donor bioactivation. Mol Pharmacol. 1999 Aug; 56(2):243-53. PMID: 10419542.
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    17. Kotsonis P, Frey A, Fröhlich LG, Hofmann H, Reif A, Wink DA, Feelisch M, Schmidt HH. Autoinhibition of neuronal nitric oxide synthase: distinct effects of reactive nitrogen and oxygen species on enzyme activity. Biochem J. 1999 Jun 15; 340 ( Pt 3):745-52. PMID: 10359660; PMCID: PMC1220307.
    18. Iannazzo L, Kotsonis P, Majewski H. . Br J Pharmacol. The structural requirements for phorbol esters to enhance serotonin and acetylcholine release from rat brain cortex. . 1999; 5(127):1177-89.
    19. Bömmel HM, Reif A, Fröhlich LG, Frey A, Hofmann H, Marecak DM, Groehn V, Kotsonis P, La M, Köster S, Meinecke M, Bernhardt M, Weeger M, Ghisla S, Prestwich GD, Pfleiderer W, Schmidt HH. Anti-pterins as tools to characterize the function of tetrahydrobiopterin in NO synthase. J Biol Chem. 1998 Dec 11; 273(50):33142-9. PMID: 9837881.
      View in: PubMed
    20. Majewski H, Kotsonis P, Murphy TV, Barrington M. Noradrenaline release and the effect of endogenous activation of the phospholipase C/protein kinase C signalling pathway in rat atria. Br J Pharmacol. 1997 Jul; 121(6):1196-202. PMID: 9249257; PMCID: PMC1564795.
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