William Grossman, MD

Title(s)Professor, Medicine
SchoolSchool of Medicine
Address555 Mission Bay Blvd South
San Francisco CA 94158
Phone415-502-8628
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    Yale UniversityM.D.1965School of Medicine

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    CLINICAL INTERESTS; Dr. Grossman is a cardiologist and director of the Center for Prevention of Heart and Vascular Disease at Mission Bay. He is the Charles and Helen Schwab Endowed Chair in Preventive Cardiology at UCSF and a former chief of Cardiology at UCSF Medical Center. He specializes in treatments to prevent the development or progression of heart disease and cares for patients with hypertension (high blood pressure), dyslipidemia (abnormal cholesterol), coronary artery disease (previous or recent heart attack and angina), valvular heart disease, atrial fibrillation, cardiomyopathy and heart failure.

    RESEARCH INTERESTS; Dr. Grossman has been a pioneer in research on diastolic function of the heart, and causes of cardiac muscle hypertrophy. He has also done research on the development of new treatments for heart failure, and valvular heart disease. He is editor of the textbook "Grossman's Cardiac Catheterization, Angiography and Intervention," which remains a standard in the field.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Echocardiographic determination of pulmonary arterial capacitance. Int J Cardiovasc Imaging. 2019 Sep; 35(9):1581-1586. Papolos A, Fan E, Wagle RR, Foster E, Boyle AJ, Yeghiazarians Y, MacGregor JS, Grossman W, Schiller NB, Ganz P, Tison GH. PMID: 30968263.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    2. Bergeyella cardium: Clinical Characteristics and Draft Genome of an Emerging Pathogen in Native and Prosthetic Valve Endocarditis. Open Forum Infect Dis. 2019 Apr; 6(4):ofz134. Mulliken JS, Langelier C, Budak JZ, Miller S, Dynerman D, Hao S, Li LM, Crawford E, Lyden A, Woodworth MH, DeRisi JL, Desmond E, Browne C, Luu A, Grandis DJ, Grossman W, Deuse T, Melcher GP. PMID: 31024974.
      View in: PubMed   Mentions:
    3. Myocardial stress and hypertrophy: a complex interface between biophysics and cardiac remodeling. J Clin Invest. 2013 Sep; 123(9):3701-3. Grossman W, Paulus WJ. PMID: 23999445.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    4. Validity of self-reported adult secondhand smoke exposure. Tob Control. 2015 Jan; 24(1):48-53. Prochaska JJ, Grossman W, Young-Wolff KC, Benowitz NL. PMID: 23997071.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansPHPublic Health
    5. Sca-1+ cardiosphere-derived cells are enriched for Isl1-expressing cardiac precursors and improve cardiac function after myocardial injury. PLoS One. 2012; 7(1):e30329. Ye J, Boyle A, Shih H, Sievers RE, Zhang Y, Prasad M, Su H, Zhou Y, Grossman W, Bernstein HS, Yeghiazarians Y. PMID: 22272337.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    6. Advanced Donor Age Impairs Bone Marrow Cell Therapeutic Efficacy for Cardiac Disease. J Tissue Sci Eng. 2011 Nov 18; S3. Wang X, Takagawa J, Haddad DJ, Pinnamaneni K, Zhang Y, Sievers RE, Grossman W, Yeghiazarians Y, Springer ML. PMID: 22675670.
      View in: PubMed   Mentions:
    7. Granzyme B regulates antiviral CD8+ T cell responses. J Immunol. 2011 Dec 15; 187(12):6301-9. Salti SM, Hammelev EM, Grewal JL, Reddy ST, Zemple SJ, Grossman WJ, Grayson MH, Verbsky JW. PMID: 22084442.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    8. Cardiology Rx for Change: improving clinical attention to tobacco use and secondhand smoke exposure in cardiology. Clin Cardiol. 2011 Dec; 34(12):738-43. Prochaska JJ, Benowitz NL, Glantz SA, Hudmon KS, Grossman W. PMID: 21987417.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansPHPublic Health
    9. Human phagocyte defect caused by a Rac2 mutation detected by means of neonatal screening for T-cell lymphopenia. J Allergy Clin Immunol. 2011 Feb; 127(2):535-538.e1-2. Accetta D, Syverson G, Bonacci B, Reddy S, Bengtson C, Surfus J, Harbeck R, Huttenlocher A, Grossman W, Routes J, Verbsky J. PMID: 21167572.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCellsPHPublic Health
    10. Cytokine combination therapy with erythropoietin and granulocyte colony stimulating factor in a porcine model of acute myocardial infarction. Cardiovasc Drugs Ther. 2010 Dec; 24(5-6):409-20. Angeli FS, Amabile N, Shapiro M, Mirsky R, Bartlett L, Zhang Y, Virmani R, Chatterjee K, Boyle A, Grossman W, Yeghiazarians Y. PMID: 20809214.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    11. Nitric oxide synthase expression and functional response to nitric oxide are both important modulators of circulating angiogenic cell response to angiogenic stimuli. Arterioscler Thromb Vasc Biol. 2010 Nov; 30(11):2212-8. Heiss C, Schanz A, Amabile N, Jahn S, Chen Q, Wong ML, Rassaf T, Heinen Y, Cortese-Krott M, Grossman W, Yeghiazarians Y, Springer ML. PMID: 20705916.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    12. Impact of trough IgG on pneumonia incidence in primary immunodeficiency: A meta-analysis of clinical studies. Clin Immunol. 2010 Oct; 137(1):21-30. Orange JS, Grossman WJ, Navickis RJ, Wilkes MM. PMID: 20675197.
      View in: PubMed   Mentions: 118     Fields:    Translation:Humans
    13. Timing of bone marrow cell therapy is more important than repeated injections after myocardial infarction. Cardiovasc Pathol. 2011 Jul-Aug; 20(4):204-12. Zhang Y, Sievers RE, Prasad M, Mirsky R, Shih H, Wong ML, Angeli FS, Ye J, Takagawa J, Koskenvuo JW, Springer ML, Grossman W, Boyle AJ, Yeghiazarians Y. PMID: 20667749.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    14. Improvement of endothelial function with dietary flavanols is associated with mobilization of circulating angiogenic cells in patients with coronary artery disease. J Am Coll Cardiol. 2010 Jul 13; 56(3):218-24. Heiss C, Jahn S, Taylor M, Real WM, Angeli FS, Wong ML, Amabile N, Prasad M, Rassaf T, Ottaviani JI, Mihardja S, Keen CL, Springer ML, Boyle A, Grossman W, Glantz SA, Schroeter H, Yeghiazarians Y. PMID: 20620742.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    15. Granulocyte colony stimulating factor in myocardial infarction with low ejection fraction. Cytokine. 2010 Sep; 51(3):278-85. Angeli FS, Smith C, Amabile N, Shapiro M, Bartlett L, Virmani R, Chatterjee K, Boyle A, Grossman W, Yeghiazarians Y. PMID: 20609597.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    16. Multiplexed quantitative real-time PCR to detect 22q11.2 deletion in patients with congenital heart disease. Physiol Genomics. 2010 Sep; 42A(1):52-60. Tomita-Mitchell A, Mahnke DK, Larson JM, Ghanta S, Feng Y, Simpson PM, Broeckel U, Duffy K, Tweddell JS, Grossman WJ, Routes JM, Mitchell ME. PMID: 20551144.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    17. Immunosuppressive effects in infants treated with corticosteroids for infantile hemangiomas. Arch Dermatol. 2010 Jul; 146(7):767-74. Kelly ME, Juern AM, Grossman WJ, Schauer DW, Drolet BA. PMID: 20479291.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    18. Cytokine combination therapy with long-acting erythropoietin and granulocyte colony stimulating factor improves cardiac function but is not superior than monotherapy in a mouse model of acute myocardial infarction. J Card Fail. 2010 Aug; 16(8):669-78. Yeghiazarians Y, Khan M, Angeli FS, Zhang Y, Jahn S, Prasad M, Mirsky R, Shih H, Minasi P, Boyle A, Grossman W. PMID: 20670846.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    19. Prolonged therapy with erythropoietin is safe and prevents deterioration of left ventricular systolic function in a porcine model of myocardial infarction. J Card Fail. 2010 Jul; 16(7):579-89. Angeli FS, Amabile N, Burjonroppa S, Shapiro M, Bartlett L, Zhang Y, Virmani R, Chatterjee K, Boyle A, Grossman W, Yeghiazarians Y. PMID: 20610234.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    20. Increased CD62e(+) endothelial microparticle levels predict poor outcome in pulmonary hypertension patients. J Heart Lung Transplant. 2009 Oct; 28(10):1081-6. Amabile N, Heiss C, Chang V, Angeli FS, Damon L, Rame EJ, McGlothlin D, Grossman W, De Marco T, Yeghiazarians Y. PMID: 19782291.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    21. Combining angiogenic gene and stem cell therapies for myocardial infarction. J Gene Med. 2009 Sep; 11(9):743-53. Pons J, Huang Y, Takagawa J, Arakawa-Hoyt J, Ye J, Grossman W, Kan YW, Su H. PMID: 19554624.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    22. The role of NF-kappaB and Smad3 in TGF-beta-mediated Foxp3 expression. Eur J Immunol. 2009 Sep; 39(9):2571-83. Jana S, Jailwala P, Haribhai D, Waukau J, Glisic S, Grossman W, Mishra M, Wen R, Wang D, Williams CB, Ghosh S. PMID: 19701891.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    23. Left ventricular remodeling after myocardial infarction: characterization of a swine model on beta-blocker therapy. Comp Med. 2009 Jun; 59(3):272-9. Angeli FS, Shapiro M, Amabile N, Orcino G, Smith CS, Tacy T, Boyle AJ, Chatterjee K, Glantz SA, Grossman W, Yeghiazarians Y. PMID: 19619418.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    24. Development of a routine newborn screening protocol for severe combined immunodeficiency. J Allergy Clin Immunol. 2009 Sep; 124(3):522-7. Baker MW, Grossman WJ, Laessig RH, Hoffman GL, Brokopp CD, Kurtycz DF, Cogley MF, Litsheim TJ, Katcher ML, Routes JM. PMID: 19482345.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansPHPublic Health
    25. Invasive left ventricular energetics during enhanced external counterpulsation. Am J Ther. 2009 May-Jun; 16(3):239-46. Michaels AD, Tacy T, Teitel D, Shapiro M, Grossman W. PMID: 19145208.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    26. Injection of bone marrow cell extract into infarcted hearts results in functional improvement comparable to intact cell therapy. Mol Ther. 2009 Jul; 17(7):1250-6. Yeghiazarians Y, Zhang Y, Prasad M, Shih H, Saini SA, Takagawa J, Sievers RE, Wong ML, Kapasi NK, Mirsky R, Koskenvuo J, Minasi P, Ye J, Viswanathan MN, Angeli FS, Boyle AJ, Springer ML, Grossman W. PMID: 19384293.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    27. VEGF improves survival of mesenchymal stem cells in infarcted hearts. Biochem Biophys Res Commun. 2008 Nov 14; 376(2):419-22. Pons J, Huang Y, Arakawa-Hoyt J, Washko D, Takagawa J, Ye J, Grossman W, Su H. PMID: 18789891.
      View in: PubMed   Mentions: 52     Fields:    Translation:AnimalsCells
    28. Brief secondhand smoke exposure depresses endothelial progenitor cells activity and endothelial function: sustained vascular injury and blunted nitric oxide production. J Am Coll Cardiol. 2008 May 06; 51(18):1760-71. Heiss C, Amabile N, Lee AC, Real WM, Schick SF, Lao D, Wong ML, Jahn S, Angeli FS, Minasi P, Springer ML, Hammond SK, Glantz SA, Grossman W, Balmes JR, Yeghiazarians Y. PMID: 18452782.
      View in: PubMed   Mentions: 88     Fields:    Translation:HumansCellsPHPublic Health
    29. Additive effect of AAV-mediated angiopoietin-1 and VEGF expression on the therapy of infarcted heart. Int J Cardiol. 2009 Apr 03; 133(2):191-7. Su H, Takagawa J, Huang Y, Arakawa-Hoyt J, Pons J, Grossman W, Kan YW. PMID: 18295361.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    30. Circulating endothelial microparticle levels predict hemodynamic severity of pulmonary hypertension. Am J Respir Crit Care Med. 2008 Jun 01; 177(11):1268-75. Amabile N, Heiss C, Real WM, Minasi P, McGlothlin D, Rame EJ, Grossman W, De Marco T, Yeghiazarians Y. PMID: 18310479.
      View in: PubMed   Mentions: 58     Fields:    Translation:Humans
    31. Portable enhanced external counterpulsation for acute coronary syndrome and cardiogenic shock: a pilot study. Clin Cardiol. 2007 May; 30(5):223-8. Cohen J, Grossman W, Michaels AD. PMID: 17492675.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCTClinical Trials
    32. Myocardial infarct size measurement in the mouse chronic infarction model: comparison of area- and length-based approaches. J Appl Physiol (1985). 2007 Jun; 102(6):2104-11. Takagawa J, Zhang Y, Wong ML, Sievers RE, Kapasi NK, Wang Y, Yeghiazarians Y, Lee RJ, Grossman W, Springer ML. PMID: 17347379.
      View in: PubMed   Mentions: 112     Fields:    Translation:HumansAnimals
    33. Left ventricular pressure-volume relationship in conscious mice. . 2007 Jan; 292(1):H369-77. Joho S, Ishizaka S, Sievers R, Foster E, Simpson PC, Grossman W. PMID: 16905597.
      View in: PubMed   Mentions:
    34. Cellular and genetic basis of primary immune deficiencies. Pediatr Clin North Am. 2006 Aug; 53(4):649-84. Verbsky JW, Grossman WJ. PMID: 16872998.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    35. Alpha1-adrenergic receptors prevent a maladaptive cardiac response to pressure overload. J Clin Invest. 2006 Apr; 116(4):1005-15. O'Connell TD, Swigart PM, Rodrigo MC, Ishizaka S, Joho S, Turnbull L, Tecott LH, Baker AJ, Foster E, Grossman W, Simpson PC. PMID: 16585965.
      View in: PubMed   Mentions: 62     Fields:    Translation:AnimalsCells
    36. Hemophagocytic lymphohistiocytosis: diagnosis, pathophysiology, treatment, and future perspectives. Ann Med. 2006; 38(1):20-31. Verbsky JW, Grossman WJ. PMID: 16448985.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    37. Allergic dysregulation and hyperimmunoglobulinemia E in Foxp3 mutant mice. J Allergy Clin Immunol. 2005 Nov; 116(5):1106-15. Lin W, Truong N, Grossman WJ, Haribhai D, Williams CB, Wang J, Martín MG, Chatila TA. PMID: 16275384.
      View in: PubMed   Mentions: 78     Fields:    Translation:AnimalsCells
    38. Closed-chest cell injections into mouse myocardium guided by high-resolution echocardiography. . 2005 Sep; 289(3):H1307-14. Springer ML, Sievers RE, Viswanathan MN, Yee MS, Foster E, Grossman W, Yeghiazarians Y. PMID: 15908468.
      View in: PubMed   Mentions:
    39. Cardiac transgenesis with the tetracycline transactivator changes myocardial function and gene expression. Physiol Genomics. 2005 Jun 16; 22(1):118-26. McCloskey DT, Turnbull L, Swigart PM, Zambon AC, Turcato S, Joho S, Grossman W, Conklin BR, Simpson PC, Baker AJ. PMID: 15797971.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    40. Granzyme B and the downstream granzymes C and/or F are important for cytotoxic lymphocyte functions. J Immunol. 2005 Feb 15; 174(4):2124-31. Revell PA, Grossman WJ, Thomas DA, Cao X, Behl R, Ratner JA, Lu ZH, Ley TJ. PMID: 15699143.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    41. Adeno-associated viral vector delivers cardiac-specific and hypoxia-inducible VEGF expression in ischemic mouse hearts. Proc Natl Acad Sci U S A. 2004 Nov 16; 101(46):16280-5. Su H, Joho S, Huang Y, Barcena A, Arakawa-Hoyt J, Grossman W, Kan YW. PMID: 15534198.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    42. Differential expression of granzymes A and B in human cytotoxic lymphocyte subsets and T regulatory cells. Blood. 2004 Nov 01; 104(9):2840-8. Grossman WJ, Verbsky JW, Tollefsen BL, Kemper C, Atkinson JP, Ley TJ. PMID: 15238416.
      View in: PubMed   Mentions: 167     Fields:    Translation:HumansAnimalsCells
    43. New technique for measurement of left ventricular pressure in conscious mice. . 2004 Mar; 286(3):H1208-15. Ishizaka S, Sievers RE, Zhu BQ, Rodrigo MC, Joho S, Foster E, Simpson PC, Grossman W. PMID: 14563661.
      View in: PubMed   Mentions:
    44. The alpha(1A/C)- and alpha(1B)-adrenergic receptors are required for physiological cardiac hypertrophy in the double-knockout mouse. J Clin Invest. 2003 Jun; 111(11):1783-91. O'Connell TD, Ishizaka S, Nakamura A, Swigart PM, Rodrigo MC, Simpson GL, Cotecchia S, Rokosh DG, Grossman W, Foster E, Simpson PC. PMID: 12782680.
      View in: PubMed   Mentions: 70     Fields:    Translation:AnimalsCells
    45. Comparative effects of aspirin with ACE inhibitor or angiotensin receptor blocker on myocardial infarction and vascular function. J Renin Angiotensin Aldosterone Syst. 2003 Mar; 4(1):31-7. Zhu BQ, Sievers RE, Browne AE, Lee RJ, Chatterjee K, Grossman W, Karliner JS, Parmley WW. PMID: 12692751.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    46. Evaluation and management of diastolic heart failure. Circulation. 2003 Feb 11; 107(5):659-63. Angeja BG, Grossman W. PMID: 12578862.
      View in: PubMed   Mentions: 36     Fields:    Translation:Humans
    47. Left ventricular systolic unloading and augmentation of intracoronary pressure and Doppler flow during enhanced external counterpulsation. Circulation. 2002 Sep 03; 106(10):1237-42. Michaels AD, Accad M, Ports TA, Grossman W. PMID: 12208799.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCTClinical Trials
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