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Norepinephrine Signals Through Astrocytes To Modulate Synapses. bioRxiv. 2024 May 22.
Lefton KB, Wu Y, Yen A, Okuda T, Zhang Y, Dai Y, Walsh S, Manno R, Dougherty JD, Samineni VK, Simpson PC, Papouin T. PMID: 38826209; PMCID: PMC11142048.
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PubMed Mentions:
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The alpha-1A adrenergic receptor regulates mitochondrial oxidative metabolism in the mouse heart. J Mol Cell Cardiol. 2024 02; 187:101-117.
Sandroni PB, Schroder MA, Hawkins HT, Bailon JD, Huang W, Hagen JT, Montgomery M, Hong SJ, Chin AL, Zhang J, Rodrigo MC, Kim B, Simpson PC, Schisler JC, Ellis JM, Fisher-Wellman KH, Jensen BC. PMID: 38331556; PMCID: PMC10861168.
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PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
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Cardiomyocyte Alpha-1A Adrenergic Receptors Mitigate Postinfarct Remodeling and Mortality by Constraining Necroptosis. JACC Basic Transl Sci. 2024 Jan; 9(1):78-96.
Zhang J, Sandroni PB, Huang W, Gao X, Oswalt L, Schroder MA, Lee S, Shih YI, Huang HS, Swigart PM, Myagmar BE, Simpson PC, Rossi JS, Schisler JC, Jensen BC. PMID: 38362342; PMCID: PMC10864988.
View in:
PubMed Mentions:
3
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Norepinephrine links astrocytic activity to regulation of cortical state. Nat Neurosci. 2023 04; 26(4):579-593.
Reitman ME, Tse V, Mi X, Willoughby DD, Peinado A, Aivazidis A, Myagmar BE, Simpson PC, Bayraktar OA, Yu G, Poskanzer KE. PMID: 36997759; PMCID: PMC10089924.
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PubMed Mentions:
25 Fields:
Translation:
AnimalsCells
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Cardiac α1A-adrenergic receptors: emerging protective roles in cardiovascular diseases. Am J Physiol Heart Circ Physiol. 2021 02 01; 320(2):H725-H733.
Zhang J, Simpson PC, Jensen BC. PMID: 33275531; PMCID: PMC8082792.
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PubMed Mentions:
23 Fields:
Translation:
HumansAnimalsCells
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Coupling to Gq Signaling Is Required for Cardioprotection by an Alpha-1A-Adrenergic Receptor Agonist. Circ Res. 2019 09 13; 125(7):699-706.
Myagmar BE, Ismaili T, Swigart PM, Raghunathan A, Baker AJ, Sahdeo S, Blevitt JM, Milla ME, Simpson PC. PMID: 31426700; PMCID: PMC6742539.
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PubMed Mentions:
7 Fields:
Translation:
AnimalsCells
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Reversal of right ventricular failure by chronic α1A-subtype adrenergic agonist therapy. Am J Physiol Heart Circ Physiol. 2019 01 01; 316(1):H224-H232.
Cowley PM, Wang G, Swigart PM, Raghunathan A, Reddy N, Dulam P, Lovett DH, Simpson PC, Baker AJ. PMID: 30412439; PMCID: PMC6859419.
View in:
PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
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Shift toward greater pathologic post-myocardial infarction remodeling with loss of the adaptive hypertrophic signaling of alpha1 adrenergic receptors in mice. PLoS One. 2017; 12(12):e0188471.
Yeh CC, Fan Y, Xu Y, Yang YL, Simpson PC, Mann MJ. PMID: 29216197; PMCID: PMC5720786.
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PubMed Mentions:
10 Fields:
Translation:
AnimalsCells
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A method to increase reproducibility in adult ventricular myocyte sizing and flow cytometry: Avoiding cell size bias in single cell preparations. PLoS One. 2017; 12(10):e0186792.
López JE, Jaradeh K, Silva E, Aminololama-Shakeri S, Simpson PC. PMID: 29084228; PMCID: PMC5662089.
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PubMed Mentions:
2 Fields:
Translation:
AnimalsCells
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α1A-Subtype adrenergic agonist therapy for the failing right ventricle. Am J Physiol Heart Circ Physiol. 2017 Dec 01; 313(6):H1109-H1118.
Cowley PM, Wang G, Joshi S, Swigart PM, Lovett DH, Simpson PC, Baker AJ. PMID: 28822963; PMCID: PMC5814653.
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PubMed Mentions:
14 Fields:
Translation:
Animals
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Novel large-particle FACS purification of adult ventricular myocytes reveals accumulation of myosin and actin disproportionate to cell size and proteome in normal post-weaning development. J Mol Cell Cardiol. 2017 10; 111:114-122.
López JE, Sharma J, Avila J, Wood TS, VanDyke JE, McLaughlin B, Abbey CK, Wong A, Myagmar BE, Swigart PM, Simpson PC, Chiamvimonvat N. PMID: 28780067; PMCID: PMC5791888.
View in:
PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
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Response by Simpson et al to Letter Regarding Article, "Adrenergic Receptors in Individual Ventricular Myocytes: the Beta-1 and Alpha-1B Are in All Cells, the Alpha-1A Is in a Subpopulation, and the Beta-2 and Beta-3 Are Mostly Absent". Circ Res. 2017 06 09; 120(12):e56-e57.
Simpson PC, Myagmar BE, Swigart PM, Melov S, Baker AJ. PMID: 28596177; PMCID: PMC5501172.
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PubMed Mentions: Fields:
Translation:
Cells
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Adrenergic Receptors in Individual Ventricular Myocytes: The Beta-1 and Alpha-1B Are in All Cells, the Alpha-1A Is in a Subpopulation, and the Beta-2 and Beta-3 Are Mostly Absent. Circ Res. 2017 Mar 31; 120(7):1103-1115.
Myagmar BE, Flynn JM, Cowley PM, Swigart PM, Montgomery MD, Thai K, Nair D, Gupta R, Deng DX, Hosoda C, Melov S, Baker AJ, Simpson PC. PMID: 28219977; PMCID: PMC5376223.
View in:
PubMed Mentions:
57 Fields:
Translation:
AnimalsCells
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An Oral Selective Alpha-1A Adrenergic Receptor Agonist Prevents Doxorubicin Cardiotoxicity. JACC Basic Transl Sci. 2017 Feb; 2(1):39-53.
Beak J, Huang W, Parker JS, Hicks ST, Patterson C, Simpson PC, Ma A, Jin J, Jensen BC. PMID: 28286875; PMCID: PMC5343290.
View in:
PubMed Mentions:
27
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An Alpha-1A Adrenergic Receptor Agonist Prevents Acute Doxorubicin Cardiomyopathy in Male Mice. PLoS One. 2017; 12(1):e0168409.
Montgomery MD, Chan T, Swigart PM, Myagmar BE, Dash R, Simpson PC. PMID: 28081170; PMCID: PMC5231318.
View in:
PubMed Mentions:
22 Fields:
Translation:
AnimalsCells
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The alpha-1A adrenergic receptor agonist A61603 reduces cardiac polyunsaturated fatty acid and endocannabinoid metabolites associated with inflammation in vivo. Metabolomics. 2016 Oct; 12(10).
Willis MS, Ilaiwy A, Montgomery MD, Simpson PC, Jensen BC. PMID: 28533737; PMCID: PMC5437747.
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PubMed Mentions:
5 Fields:
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The Alpha-1A Adrenergic Receptor in the Rabbit Heart. PLoS One. 2016; 11(6):e0155238.
Thomas RC, Cowley PM, Singh A, Myagmar BE, Swigart PM, Baker AJ, Simpson PC. PMID: 27258143; PMCID: PMC4892533.
View in:
PubMed Mentions:
4 Fields:
Translation:
AnimalsCells
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A Myocardial Slice Culture Model Reveals Alpha-1A-Adrenergic Receptor Signaling in the Human Heart. JACC Basic Transl Sci. 2016 04; 1(3):155-167.
Thomas RC, Singh A, Cowley P, Myagmar BE, Montgomery MD, Swigart PM, De Marco T, Baker AJ, Simpson PC. PMID: 27453955; PMCID: PMC4955869.
View in:
PubMed Mentions:
21
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A New Pathway for Sympathetic Cardioprotection in Heart Failure. Circ Res. 2015 Sep 11; 117(7):592-5.
Simpson PC. PMID: 26358108; PMCID: PMC4692358.
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PubMed Mentions:
4 Fields:
Translation:
HumansAnimals
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The α1A-adrenergic receptor subtype mediates increased contraction of failing right ventricular myocardium. Am J Physiol Heart Circ Physiol. 2015 Sep; 309(5):H888-96.
Cowley PM, Wang G, Chang AN, Makwana O, Swigart PM, Lovett DH, Stull JT, Simpson PC, Baker AJ. PMID: 26116709; PMCID: PMC4591405.
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PubMed Mentions:
21 Fields:
Translation:
AnimalsCells
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Myofilament dysfunction contributes to impaired myocardial contraction in the infarct border zone. Am J Physiol Heart Circ Physiol. 2014 Oct 15; 307(8):H1150-8.
Shimkunas R, Makwana O, Spaulding K, Bazargan M, Khazalpour M, Takaba K, Soleimani M, Myagmar BE, Lovett DH, Simpson PC, Ratcliffe MB, Baker AJ. PMID: 25128171; PMCID: PMC4200338.
View in:
PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
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Alpha-1-adrenergic receptors in heart failure: the adaptive arm of the cardiac response to chronic catecholamine stimulation. J Cardiovasc Pharmacol. 2014 Apr; 63(4):291-301.
Jensen BC, O'Connell TD, Simpson PC. PMID: 24145181; PMCID: PMC3980029.
View in:
PubMed Mentions:
38 Fields:
Translation:
HumansAnimals
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Cardiac alpha1-adrenergic receptors: novel aspects of expression, signaling mechanisms, physiologic function, and clinical importance. Pharmacol Rev. 2014; 66(1):308-33.
O'Connell TD, Jensen BC, Baker AJ, Simpson PC. PMID: 24368739; PMCID: PMC3880467.
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PubMed Mentions:
87 Fields:
Translation:
HumansAnimalsCells
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Intraventricular and interventricular cellular heterogeneity of inotropic responses to α(1)-adrenergic stimulation. Am J Physiol Heart Circ Physiol. 2013 Apr 01; 304(7):H946-53.
Chu C, Thai K, Park KW, Wang P, Makwana O, Lovett DH, Simpson PC, Baker AJ. PMID: 23355341; PMCID: PMC3625891.
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PubMed Mentions:
16 Fields:
Translation:
AnimalsCells
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Synthesis of an in vivo MRI-detectable apoptosis probe. J Vis Exp. 2012 Jul 31; (65).
Lam J, Simpson PC, Yang PC, Dash R. PMID: 22871963; PMCID: PMC3476424.
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PubMed Mentions: Fields:
Translation:
HumansAnimalsCells
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Large-scale discovery of enhancers from human heart tissue. Nat Genet. 2011 Dec 04; 44(1):89-93.
May D, Blow MJ, Kaplan T, McCulley DJ, Jensen BC, Akiyama JA, Holt A, Plajzer-Frick I, Shoukry M, Wright C, Afzal V, Simpson PC, Rubin EM, Black BL, Bristow J, Pennacchio LA, Visel A. PMID: 22138689; PMCID: PMC3246570.
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PubMed Mentions:
161 Fields:
Translation:
HumansAnimalsCells
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Where are the new drugs to treat heart failure? Introduction to the special issue on "key signaling molecules in hypertrophy and heart failure". J Mol Cell Cardiol. 2011 Oct; 51(4):435-7.
Simpson PC. PMID: 21851824.
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PubMed Mentions:
5 Fields:
Translation:
HumansAnimalsCells
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Long-term α1A-adrenergic receptor stimulation improves synaptic plasticity, cognitive function, mood, and longevity. Mol Pharmacol. 2011 Oct; 80(4):747-58.
Doze VA, Papay RS, Goldenstein BL, Gupta MK, Collette KM, Nelson BW, Lyons MJ, Davis BA, Luger EJ, Wood SG, Haselton JR, Simpson PC, Perez DM. PMID: 21791575; PMCID: PMC3187532.
View in:
PubMed Mentions:
32 Fields:
Translation:
AnimalsCells
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β-myosin heavy chain is induced by pressure overload in a minor subpopulation of smaller mouse cardiac myocytes. Circ Res. 2011 Sep 02; 109(6):629-38.
López JE, Myagmar BE, Swigart PM, Montgomery MD, Haynam S, Bigos M, Rodrigo MC, Simpson PC. PMID: 21778428; PMCID: PMC3166391.
View in:
PubMed Mentions:
44 Fields:
Translation:
AnimalsCells
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A molecular MRI probe to detect treatment of cardiac apoptosis in vivo. Magn Reson Med. 2011 Oct; 66(4):1152-62.
Dash R, Chung J, Chan T, Yamada M, Barral J, Nishimura D, Yang PC, Simpson PC. PMID: 21360750; PMCID: PMC3138815.
View in:
PubMed Mentions:
25 Fields:
Translation:
AnimalsCells
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Alpha-1-adrenergic receptors: targets for agonist drugs to treat heart failure. J Mol Cell Cardiol. 2011 Oct; 51(4):518-28.
Jensen BC, O'Connell TD, Simpson PC. PMID: 21118696; PMCID: PMC3085055.
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PubMed Mentions:
62 Fields:
Translation:
HumansAnimals
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Functional alpha-1B adrenergic receptors on human epicardial coronary artery endothelial cells. Naunyn Schmiedebergs Arch Pharmacol. 2010 Dec; 382(5-6):475-82.
Jensen BC, Swigart PM, Montgomery MD, Simpson PC. PMID: 20857090; PMCID: PMC2991196.
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PubMed Mentions:
18 Fields:
Translation:
HumansCells
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Altered microRNAs in bicuspid aortic valve: a comparison between stenotic and insufficient valves. J Heart Valve Dis. 2010 Jul; 19(4):459-65.
Nigam V, Sievers HH, Jensen BC, Sier HA, Simpson PC, Srivastava D, Mohamed SA. PMID: 20845893; PMCID: PMC4242684.
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PubMed Mentions:
61 Fields:
Translation:
HumansCells
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Distinctive ERK and p38 signaling in remote and infarcted myocardium during post-MI remodeling in the mouse. J Cell Biochem. 2010 Apr 15; 109(6):1185-91.
Yeh CC, Li H, Malhotra D, Turcato S, Nicholas S, Tu R, Zhu BQ, Cha J, Swigart PM, Myagmar BE, Baker AJ, Simpson PC, Mann MJ. PMID: 20186881; PMCID: PMC3397305.
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PubMed Mentions:
22 Fields:
Translation:
AnimalsCells
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Limited forward trafficking of connexin 43 reduces cell-cell coupling in stressed human and mouse myocardium. J Clin Invest. 2010 Jan; 120(1):266-79.
Smyth JW, Hong TT, Gao D, Vogan JM, Jensen BC, Fong TS, Simpson PC, Stainier DY, Chi NC, Shaw RM. PMID: 20038810; PMCID: PMC2798685.
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PubMed Mentions:
142 Fields:
Translation:
HumansAnimalsCells
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Heart failure switches the RV alpha1-adrenergic inotropic response from negative to positive. Am J Physiol Heart Circ Physiol. 2010 Mar; 298(3):H913-20.
Wang GY, Yeh CC, Jensen BC, Mann MJ, Simpson PC, Baker AJ. PMID: 20035030; PMCID: PMC2838546.
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PubMed Mentions:
22 Fields:
Translation:
AnimalsCells
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Alpha1A/B-knockout mice explain the native alpha1D-adrenoceptor's role in vasoconstriction and show that its location is independent of the other alpha1-subtypes. Br J Pharmacol. 2009 Dec; 158(7):1663-75.
Methven L, Simpson PC, McGrath JC. PMID: 19888965; PMCID: PMC2801207.
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PubMed Mentions:
25 Fields:
Translation:
AnimalsCells
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The alpha-1D Is the predominant alpha-1-adrenergic receptor subtype in human epicardial coronary arteries. J Am Coll Cardiol. 2009 Sep 22; 54(13):1137-45.
Jensen BC, Swigart PM, Laden ME, DeMarco T, Hoopes C, Simpson PC. PMID: 19761933; PMCID: PMC2812029.
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PubMed Mentions:
35 Fields:
Translation:
HumansCells
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{alpha}1-Adrenergic receptor subtypes in nonfailing and failing human myocardium. Circ Heart Fail. 2009 Nov; 2(6):654-63.
Jensen BC, Swigart PM, De Marco T, Hoopes C, Simpson PC. PMID: 19919991; PMCID: PMC2780440.
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PubMed Mentions:
46 Fields:
Translation:
Humans
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Ten commercial antibodies for alpha-1-adrenergic receptor subtypes are nonspecific. Naunyn Schmiedebergs Arch Pharmacol. 2009 Apr; 379(4):409-12.
Jensen BC, Swigart PM, Simpson PC. PMID: 18989658; PMCID: PMC2653258.
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PubMed Mentions:
99 Fields:
Translation:
Animals
-
Identification of alpha 1L-adrenoceptor in mice and its abolition by alpha 1A-adrenoceptor gene knockout. Br J Pharmacol. 2008 Dec; 155(8):1224-34.
Muramatsu I, Morishima S, Suzuki F, Yoshiki H, Anisuzzaman AS, Tanaka T, Rodrigo MC, Myagmar BE, Simpson PC. PMID: 18806813; PMCID: PMC2607200.
View in:
PubMed Mentions:
14 Fields:
Translation:
Animals
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Epinephrine is required for normal cardiovascular responses to stress in the phenylethanolamine N-methyltransferase knockout mouse. Circulation. 2007 Aug 28; 116(9):1024-31.
Bao X, Lu CM, Liu F, Gu Y, Dalton ND, Zhu BQ, Foster E, Chen J, Karliner JS, Ross J, Simpson PC, Ziegler MG. PMID: 17698731.
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PubMed Mentions:
15 Fields:
Translation:
Animals
-
Blockade of both alpha1A- and alpha1B-adrenergic receptor subtype signaling is required to inhibit neointimal formation in the mouse femoral artery. Am J Physiol Heart Circ Physiol. 2007 Jul; 293(1):H514-9.
Hosoda C, Hiroyama M, Sanbe A, Birumachi J, Kitamura T, Cotecchia S, Simpson PC, Tsujimoto G, Tanoue A. PMID: 17384126.
View in:
PubMed Mentions:
4 Fields:
Translation:
AnimalsCells
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An alpha1A-adrenergic-extracellular signal-regulated kinase survival signaling pathway in cardiac myocytes. Circulation. 2007 Feb 13; 115(6):763-72.
Huang Y, Wright CD, Merkwan CL, Baye NL, Liang Q, Simpson PC, O'Connell TD. PMID: 17283256.
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PubMed Mentions:
78 Fields:
Translation:
AnimalsCells
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Isolation and culture of adult mouse cardiac myocytes. Methods Mol Biol. 2007; 357:271-96.
O'Connell TD, Rodrigo MC, Simpson PC. PMID: 17172694.
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PubMed Mentions:
202 Fields:
Translation:
AnimalsCells
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Left ventricular pressure-volume relationship in conscious mice. Am J Physiol Heart Circ Physiol. 2007 Jan; 292(1):H369-77.
Joho S, Ishizaka S, Sievers R, Foster E, Simpson PC, Grossman W. PMID: 16905597.
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PubMed Mentions:
16 Fields:
Translation:
Animals
-
Localization of the mouse alpha1A-adrenergic receptor (AR) in the brain: alpha1AAR is expressed in neurons, GABAergic interneurons, and NG2 oligodendrocyte progenitors. J Comp Neurol. 2006 Jul 10; 497(2):209-22.
Papay R, Gaivin R, Jha A, McCune DF, McGrath JC, Rodrigo MC, Simpson PC, Doze VA, Perez DM. PMID: 16705673.
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PubMed Mentions:
44 Fields:
Translation:
AnimalsCells
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Contrasting inotropic responses to alpha1-adrenergic receptor stimulation in left versus right ventricular myocardium. Am J Physiol Heart Circ Physiol. 2006 Oct; 291(4):H2013-7.
Wang GY, McCloskey DT, Turcato S, Swigart PM, Simpson PC, Baker AJ. PMID: 16731650.
View in:
PubMed Mentions:
44 Fields:
Translation:
AnimalsCells
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Alpha1-adrenergic receptors prevent a maladaptive cardiac response to pressure overload. J Clin Invest. 2006 Apr; 116(4):1005-15.
O'Connell TD, Swigart PM, Rodrigo MC, Ishizaka S, Joho S, Turnbull L, Tecott LH, Baker AJ, Foster E, Grossman W, Simpson PC. PMID: 16585965; PMCID: PMC1421341.
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PubMed Mentions:
74 Fields:
Translation:
AnimalsCells
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Ischemic preconditioning depends on age and gender. Basic Res Cardiol. 2006 May; 101(3):235-43.
Turcato S, Turnbull L, Wang GY, Honbo N, Simpson PC, Karliner JS, Baker AJ. PMID: 16450074.
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PubMed Mentions:
15 Fields:
Translation:
AnimalsCells
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Sustained preconditioning induced by cardiac transgenesis with the tetracycline transactivator. Am J Physiol Heart Circ Physiol. 2006 Mar; 290(3):H1103-9.
Turnbull L, Zhou HZ, Swigart PM, Turcato S, Karliner JS, Conklin BR, Simpson PC, Baker AJ. PMID: 16243914.
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PubMed Mentions:
2 Fields:
Translation:
Animals
-
Cardiac transgenic matrix metalloproteinase-2 expression directly induces impaired contractility. Cardiovasc Res. 2006 Feb 15; 69(3):688-96.
Wang GY, Bergman MR, Nguyen AP, Turcato S, Swigart PM, Rodrigo MC, Simpson PC, Karliner JS, Lovett DH, Baker AJ. PMID: 16183043.
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PubMed Mentions:
34 Fields:
Translation:
AnimalsCells
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Both alpha(1A)- and alpha(1B)-adrenergic receptors crosstalk to down regulate beta(1)-ARs in mouse heart: coupling to differential PTX-sensitive pathways. J Mol Cell Cardiol. 2005 Nov; 39(5):777-84.
Rorabaugh BR, Gaivin RJ, Papay RS, Shi T, Simpson PC, Perez DM. PMID: 16171811.
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PubMed Mentions:
5 Fields:
Translation:
AnimalsCells
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Cardiac transgenesis with the tetracycline transactivator changes myocardial function and gene expression. Physiol Genomics. 2005 Jun 16; 22(1):118-26.
McCloskey DT, Turnbull L, Swigart PM, Zambon AC, Turcato S, Joho S, Grossman W, Conklin BR, Simpson PC, Baker AJ. PMID: 15797971.
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PubMed Mentions:
20 Fields:
Translation:
AnimalsCells
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alpha1A- but not alpha1B-adrenergic receptors precondition the ischemic heart by a staurosporine-sensitive, chelerythrine-insensitive mechanism. Cardiovasc Res. 2005 Feb 01; 65(2):436-45.
Rorabaugh BR, Ross SA, Gaivin RJ, Papay RS, McCune DF, Simpson PC, Perez DM. PMID: 15639483.
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PubMed Mentions:
31 Fields:
Translation:
Animals
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Aldosterone directly stimulates cardiac myocyte hypertrophy. J Card Fail. 2004 Dec; 10(6):511-8.
Okoshi MP, Yan X, Okoshi K, Nakayama M, Schuldt AJ, O'Connell TD, Simpson PC, Lorell BH. PMID: 15599842.
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PubMed Mentions:
31 Fields:
Translation:
AnimalsCells
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New technique for measurement of left ventricular pressure in conscious mice. Am J Physiol Heart Circ Physiol. 2004 Mar; 286(3):H1208-15.
Ishizaka S, Sievers RE, Zhu BQ, Rodrigo MC, Joho S, Foster E, Simpson PC, Grossman W. PMID: 14563661.
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PubMed Mentions:
9 Fields:
Translation:
Animals
-
Abnormal myocardial contraction in alpha(1A)- and alpha(1B)-adrenoceptor double-knockout mice. J Mol Cell Cardiol. 2003 Oct; 35(10):1207-16.
McCloskey DT, Turnbull L, Swigart P, O'Connell TD, Simpson PC, Baker AJ. PMID: 14519431.
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PubMed Mentions:
22 Fields:
Translation:
AnimalsCells
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Cerebral ischemia and infarction from atheroemboli <100 microm in Size. Stroke. 2003 Aug; 34(8):1976-80.
Rapp JH, Pan XM, Yu B, Swanson RA, Higashida RT, Simpson P, Saloner D. PMID: 12855822.
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PubMed Mentions:
28 Fields:
Translation:
HumansAnimalsCells
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The alpha(1A/C)- and alpha(1B)-adrenergic receptors are required for physiological cardiac hypertrophy in the double-knockout mouse. J Clin Invest. 2003 Jun; 111(11):1783-91.
O'Connell TD, Ishizaka S, Nakamura A, Swigart PM, Rodrigo MC, Simpson GL, Cotecchia S, Rokosh DG, Grossman W, Foster E, Simpson PC. PMID: 12782680; PMCID: PMC156101.
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PubMed Mentions:
85 Fields:
Translation:
AnimalsCells
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Basal and alpha1-adrenergic-induced activity of minimal rat betaMHC promoters in cardiac myocytes requires multiple TEF-1 but not NFAT binding sites. J Mol Cell Cardiol. 2003 May; 35(5):461-71.
McLean BG, Lee KS, Simpson PC, Farrance IK. PMID: 12738228.
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PubMed Mentions:
7 Fields:
Translation:
AnimalsCells
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Overview of the Alliance for Cellular Signaling. Nature. 2002 Dec 12; 420(6916):703-6.
Gilman AG, Simon MI, Bourne HR, Harris BA, Long R, Ross EM, Stull JT, Taussig R, Bourne HR, Arkin AP, Cobb MH, Cyster JG, Devreotes PN, Ferrell JE, Fruman D, Gold M, Weiss A, Stull JT, Berridge MJ, Cantley LC, Catterall WA, Coughlin SR, Olson EN, Smith TF, Brugge JS, Botstein D, Dixon JE, Hunter T, Lefkowitz RJ, Pawson AJ, Sternberg PW, Varmus H, Subramaniam S, Sinkovits RS, Li J, Mock D, Ning Y, Saunders B, Sternweis PC, Hilgemann D, Scheuermann RH, DeCamp D, Hsueh R, Lin KM, Ni Y, Seaman WE, Simpson PC, O'Connell TD, Roach T, Simon MI, Choi S, Eversole-Cire P, Fraser I, Mumby MC, Zhao Y, Brekken D, Shu H, Meyer T, Chandy G, Heo WD, Liou J, O'Rourke N, Verghese M, Mumby SM, Han H, Brown HA, Forrester JS, Ivanova P, Milne SB, Casey PJ, Harden TK, Arkin AP, Doyle J, Gray ML, Meyer T, Michnick S, Schmidt MA, Toner M, Tsien RY, Natarajan M, Ranganathan R, Sambrano GR, Participating investigators and scientists of the Alliance for Cellular Signaling. PMID: 12478301.
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PubMed Mentions:
35 Fields:
Translation:
HumansCells
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Alpha 1-adrenergic receptor responses in alpha 1AB-AR knockout mouse hearts suggest the presence of alpha 1D-AR. Am J Physiol Heart Circ Physiol. 2003 Apr; 284(4):H1104-9.
Turnbull L, McCloskey DT, O'Connell TD, Simpson PC, Baker AJ. PMID: 12595294.
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PubMed Mentions:
28 Fields:
Translation:
Animals
-
Alpha(1)-adrenoceptor subtypes mediate negative inotropy in myocardium from alpha(1A/C)-knockout and wild type mice. J Mol Cell Cardiol. 2002 Aug; 34(8):1007-17.
McCloskey DT, Rokosh DG, O'Connell TD, Keung EC, Simpson PC, Baker AJ. PMID: 12234770.
View in:
PubMed Mentions:
12 Fields:
Translation:
Animals
-
Knockout of the alpha 1A/C-adrenergic receptor subtype: the alpha 1A/C is expressed in resistance arteries and is required to maintain arterial blood pressure. Proc Natl Acad Sci U S A. 2002 Jul 09; 99(14):9474-9.
Rokosh DG, Simpson PC. PMID: 12093905; PMCID: PMC123165.
View in:
PubMed Mentions:
65 Fields:
Translation:
Animals
-
Regulation of thyroid hormone receptor isoforms in physiological and pathological cardiac hypertrophy. Circ Res. 2001 Sep 28; 89(7):591-8.
Kinugawa K, Yonekura K, Ribeiro RC, Eto Y, Aoyagi T, Baxter JD, Camacho SA, Bristow MR, Long CS, Simpson PC. PMID: 11577024.
View in:
PubMed Mentions:
55 Fields:
Translation:
AnimalsCells
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LV systolic performance improves with development of hypertrophy after transverse aortic constriction in mice. Am J Physiol Heart Circ Physiol. 2001 Sep; 281(3):H1104-12.
Nakamura A, Rokosh DG, Paccanaro M, Yee RR, Simpson PC, Grossman W, Foster E. PMID: 11514276.
View in:
PubMed Mentions:
35 Fields:
Translation:
Animals
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Cloning and characterization of the mouse alpha1C/A-adrenergic receptor gene and analysis of an alpha1C promoter in cardiac myocytes: role of an MCAT element that binds transcriptional enhancer factor-1 (TEF-1). Mol Pharmacol. 2001 May; 59(5):1225-34.
O'Connell TD, Rokosh DG, Simpson PC. PMID: 11306707.
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8 Fields:
Translation:
AnimalsCells
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Abnormal contraction caused by expression of G(i)-coupled receptor in transgenic model of dilated cardiomyopathy. Am J Physiol Heart Circ Physiol. 2001 Apr; 280(4):H1653-9.
Baker AJ, Redfern CH, Harwood MD, Simpson PC, Conklin BR. PMID: 11247776.
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PubMed Mentions:
6 Fields:
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HumansAnimalsCells
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Tumor cell splice variants of the transcription factor TEF-1 induced by SV40 T-antigen transformation. Biochim Biophys Acta. 2000 Dec 15; 1517(1):82-90.
Zuzarte PC, Farrance IK, Simpson PC, Wildeman AG. PMID: 11118619.
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PubMed Mentions:
7 Fields:
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HumansAnimalsCells
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Autonomous and growth factor-induced hypertrophy in cultured neonatal mouse cardiac myocytes. Comparison with rat. Circ Res. 2000 Oct 27; 87(9):781-8.
Deng XF, Rokosh DG, Simpson PC. PMID: 11055982.
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PubMed Mentions:
40 Fields:
Translation:
AnimalsCells
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Beta-protein kinase C and hypertrophic signaling in human heart failure. Circulation. 1999 Jan 26; 99(3):334-7.
Simpson PC. PMID: 9918516.
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PubMed Mentions:
11 Fields:
Translation:
HumansCells
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Post-infarction heart failure in the rat is associated with distinct alterations in cardiac myocyte molecular phenotype. J Mol Cell Cardiol. 1998 Aug; 30(8):1615-30.
Yue P, Long CS, Austin R, Chang KC, Simpson PC, Massie BM. PMID: 9737947.
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PubMed Mentions:
20 Fields:
Translation:
AnimalsCells
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Cytokine expression increases in nonmyocytes from rats with postinfarction heart failure. Am J Physiol. 1998 07; 275(1):H250-8.
Yue P, Massie BM, Simpson PC, Long CS. PMID: 9688921.
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29 Fields:
Translation:
AnimalsCells
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Thyroid hormone improves function and Ca2+ handling in pressure overload hypertrophy. Association with increased sarcoplasmic reticulum Ca2+-ATPase and alpha-myosin heavy chain in rat hearts. J Clin Invest. 1997 Oct 01; 100(7):1742-9.
Chang KC, Figueredo VM, Schreur JH, Kariya K, Weiner MW, Simpson PC, Camacho SA. PMID: 9312172; PMCID: PMC508357.
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PubMed Mentions:
18 Fields:
Translation:
AnimalsCells
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Alpha1-adrenergic receptor subtype mRNAs are differentially regulated by alpha1-adrenergic and other hypertrophic stimuli in cardiac myocytes in culture and in vivo. Repression of alpha1B and alpha1D but induction of alpha1C. J Biol Chem. 1996 Mar 08; 271(10):5839-43.
Rokosh DG, Stewart AF, Chang KC, Bailey BA, Karliner JS, Camacho SA, Long CS, Simpson PC. PMID: 8621454.
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PubMed Mentions:
32 Fields:
Translation:
AnimalsCells
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M-CAT, CArG, and Sp1 elements are required for alpha 1-adrenergic induction of the skeletal alpha-actin promoter during cardiac myocyte hypertrophy. Transcriptional enhancer factor-1 and protein kinase C as conserved transducers of the fetal program in cardiac growth. J Biol Chem. 1995 Jan 06; 270(1):410-7.
Karns LR, Kariya K, Simpson PC. PMID: 7814403.
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35 Fields:
Translation:
AnimalsCells
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Cloning of the rat alpha 1C-adrenergic receptor from cardiac myocytes. alpha 1C, alpha 1B, and alpha 1D mRNAs are present in cardiac myocytes but not in cardiac fibroblasts. Circ Res. 1994 Oct; 75(4):796-802.
Stewart AF, Rokosh DG, Bailey BA, Karns LR, Chang KC, Long CS, Kariya K, Simpson PC. PMID: 7923624.
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28 Fields:
Translation:
AnimalsCells
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Distribution of alpha 1C-adrenergic receptor mRNA in adult rat tissues by RNase protection assay and comparison with alpha 1B and alpha 1D. Biochem Biophys Res Commun. 1994 May 16; 200(3):1177-84.
Rokosh DG, Bailey BA, Stewart AF, Karns LR, Long CS, Simpson PC. PMID: 8185565.
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33 Fields:
Translation:
AnimalsCells
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An enhancer core element mediates stimulation of the rat beta-myosin heavy chain promoter by an alpha 1-adrenergic agonist and activated beta-protein kinase C in hypertrophy of cardiac myocytes. J Biol Chem. 1994 Feb 04; 269(5):3775-82.
Kariya K, Karns LR, Simpson PC. PMID: 8106422.
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PubMed Mentions:
29 Fields:
Translation:
HumansAnimalsCells
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Transcriptional enhancer factor-1 in cardiac myocytes interacts with an alpha 1-adrenergic- and beta-protein kinase C-inducible element in the rat beta-myosin heavy chain promoter. J Biol Chem. 1993 Dec 15; 268(35):26658-62.
Kariya K, Farrance IK, Simpson PC. PMID: 8253797.
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PubMed Mentions:
21 Fields:
Translation:
AnimalsCells
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Beta-adrenergic stimulation of cardiac non-myocytes augments the growth-promoting activity of non-myocyte conditioned medium. J Mol Cell Cardiol. 1993 Aug; 25(8):915-25.
Long CS, Hartogensis WE, Simpson PC. PMID: 7505339.
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PubMed Mentions:
10 Fields:
Translation:
AnimalsCells
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Sympathetic modulation of the cardiac myocyte phenotype: studies with a cell-culture model of myocardial hypertrophy. Basic Res Cardiol. 1992; 87 Suppl 2:19-31.
Long CS, Kariya K, Karns L, Simpson PC. PMID: 1338564.
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PubMed Mentions:
8 Fields:
Translation:
AnimalsCells
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A growth factor for cardiac myocytes is produced by cardiac nonmyocytes. Cell Regul. 1991 Dec; 2(12):1081-95.
Long CS, Henrich CJ, Simpson PC. PMID: 1801925; PMCID: PMC361907.
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PubMed Mentions:
35 Fields:
Translation:
AnimalsCells
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Expression of a constitutively activated mutant of the beta-isozyme of protein kinase C in cardiac myocytes stimulates the promoter of the beta-myosin heavy chain isogene. J Biol Chem. 1991 Jun 05; 266(16):10023-6.
Kariya K, Karns LR, Simpson PC. PMID: 2037558.
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PubMed Mentions:
32 Fields:
Translation:
AnimalsCells
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Adrenergic hormones and control of cardiac myocyte growth. Mol Cell Biochem. 1991 May 29-Jun 12; 104(1-2):35-43.
Simpson PC, Kariya K, Karns LR, Long CS, Karliner JS. PMID: 1656195.
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PubMed Mentions:
25 Fields:
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Sympathetic activity: modulator of myocardial hypertrophy. J Cardiovasc Pharmacol. 1991; 17 Suppl 2:S20-4.
Long CS, Kariya K, Karns L, Simpson PC. PMID: 1715479.
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PubMed Mentions:
2 Fields:
Translation:
AnimalsCells
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Trophic factors for cardiac myocytes. J Hypertens Suppl. 1990 Dec; 8(7):S219-24.
Long CS, Kariya K, Karns L, Simpson PC. PMID: 1965655.
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PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
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A protein kinase C isozyme is translocated to cytoskeletal elements on activation. Cell Regul. 1990 Aug; 1(9):693-706.
Mochly-Rosen D, Henrich CJ, Cheever L, Khaner H, Simpson PC. PMID: 2078573; PMCID: PMC361636.
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PubMed Mentions:
53 Fields:
Translation:
AnimalsCells
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The cardiac beta-myosin heavy chain isogene is induced selectively in alpha 1-adrenergic receptor-stimulated hypertrophy of cultured rat heart myocytes. J Clin Invest. 1990 Apr; 85(4):1206-14.
Waspe LE, Ordahl CP, Simpson PC. PMID: 2156896; PMCID: PMC296553.
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PubMed Mentions:
50 Fields:
Translation:
AnimalsCells
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Effects of pertussis toxin on alpha 1-agonist-mediated phosphatidylinositide turnover and myocardial cell hypertrophy in neonatal rat ventricular myocytes. Experientia. 1990 Jan 15; 46(1):81-4.
Karliner JS, Kagiya T, Simpson PC. PMID: 2153573.
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PubMed Mentions:
11 Fields:
Translation:
AnimalsCells
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Transcription of early developmental isogenes in cardiac myocyte hypertrophy. J Mol Cell Cardiol. 1989 Dec; 21 Suppl 5:79-89.
Simpson PC, Long CS, Waspe LE, Henrich CJ, Ordahl CP. PMID: 2560798.
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PubMed Mentions:
18 Fields:
Translation:
AnimalsCells
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Alpha 1-adrenergic receptor stimulation of sarcomeric actin isogene transcription in hypertrophy of cultured rat heart muscle cells. J Clin Invest. 1989 Mar; 83(3):1078-82.
Long CS, Ordahl CP, Simpson PC. PMID: 2537847; PMCID: PMC303787.
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PubMed Mentions:
28 Fields:
Translation:
AnimalsCells
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Proto-oncogenes and cardiac hypertrophy. Annu Rev Physiol. 1989; 51:189-202.
Simpson PC. PMID: 2469381.
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16 Fields:
Translation:
AnimalsCells
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Differential acute and chronic response of protein kinase C in cultured neonatal rat heart myocytes to alpha 1-adrenergic and phorbol ester stimulation. J Mol Cell Cardiol. 1988 Dec; 20(12):1081-5.
Henrich CJ, Simpson PC. PMID: 2907916.
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PubMed Mentions:
34 Fields:
Translation:
AnimalsCells
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Beta-adrenoceptor and adenylate cyclase regulation in cardiac myocyte growth. Basic Res Cardiol. 1988 Nov-Dec; 83(6):655-63.
Karliner JS, Simpson PC. PMID: 2851972.
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PubMed Mentions:
4 Fields:
Translation:
AnimalsCells
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Role of proto-oncogenes in myocardial hypertrophy. Am J Cardiol. 1988 Oct 05; 62(11):13G-19G.
Simpson PC. PMID: 2972186.
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PubMed Mentions:
4 Fields:
Translation:
HumansCells
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Comments on "Load regulation of the properties of adult feline cardiocytes: the role of substrate adhesion."Circ Res 1986;58:692-705. Circ Res. 1988 Apr; 62(4):864-9.
Simpson PC. PMID: 3349579.
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PubMed Mentions:
4 Fields:
Translation:
AnimalsCells
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Induction of the skeletal alpha-actin gene in alpha 1-adrenoceptor-mediated hypertrophy of rat cardiac myocytes. J Clin Invest. 1987 Oct; 80(4):1194-9.
Bishopric NH, Simpson PC, Ordahl CP. PMID: 2821075; PMCID: PMC442365.
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41 Fields:
Translation:
AnimalsCells
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Cardiac myocyte hypertrophy is associated with c-myc protooncogene expression. Proc Natl Acad Sci U S A. 1986 Nov; 83(21):8348-50.
Starksen NF, Simpson PC, Bishopric N, Coughlin SR, Lee WM, Escobedo JA, Williams LT. PMID: 3022291; PMCID: PMC386925.
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PubMed Mentions:
63 Fields:
Translation:
AnimalsCells
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Mechanisms and time course of beta 1 adrenoceptor desensitisation in mammalian cardiac myocytes. Cardiovasc Res. 1986 Mar; 20(3):221-8.
Karliner JS, Simpson PC, Honbo N, Woloszyn W. PMID: 3011269.
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PubMed Mentions:
15 Fields:
Translation:
AnimalsCells
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Stimulation of hypertrophy of cultured neonatal rat heart cells through an alpha 1-adrenergic receptor and induction of beating through an alpha 1- and beta 1-adrenergic receptor interaction. Evidence for independent regulation of growth and beating. Circ Res. 1985 Jun; 56(6):884-94.
Simpson P. PMID: 2988814.
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PubMed Mentions:
117 Fields:
Translation:
AnimalsCells
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Adrenergic receptor characteristics of cardiac myocytes cultured in serum-free medium: comparison with serum-supplemented medium. Biochem Biophys Res Commun. 1985 Apr 16; 128(1):376-82.
Karliner JS, Simpson PC, Taylor JE, Honbo N, Woloszyn W. PMID: 3985976.
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PubMed Mentions:
10 Fields:
Translation:
Animals
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Antihypertensive therapy with diltiazem and comparison with hydrochlorothiazide. Am J Cardiol. 1984 Jun 01; 53(11):1588-92.
Inouye IK, Massie BM, Benowitz N, Simpson P, Loge D. PMID: 6375339.
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PubMed Mentions:
9 Fields:
Translation:
Humans
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Failure of antihypertensive therapy with diuretic, beta-blocking and calcium channel-blocking drugs to consistently reverse left ventricular diastolic filling abnormalities. Am J Cardiol. 1984 Jun 01; 53(11):1583-7.
Inouye IK, Massie BM, Loge D, Simpson P, Tubau JF. PMID: 6731303.
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PubMed Mentions:
7 Fields:
Translation:
Humans
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Monotherapy in mild to moderate hypertension: comparison of hydrochlorothiazide, propranolol and prazosin. Am J Cardiol. 1984 Jan 27; 53(3):24A-28A.
Inouye I, Massie B, Benowitz N, Simpson P, Loge D, Topic N. PMID: 6320622.
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HumansCells
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Abnormal left ventricular filling: an early finding in mild to moderate systemic hypertension. Am J Cardiol. 1984 Jan 01; 53(1):120-6.
Inouye I, Massie B, Loge D, Topic N, Silverstein D, Simpson P, Tubau J. PMID: 6691248.
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PubMed Mentions:
54 Fields:
Translation:
Humans
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Norepinephrine-stimulated hypertrophy of cultured rat myocardial cells is an alpha 1 adrenergic response. J Clin Invest. 1983 Aug; 72(2):732-8.
Simpson P. PMID: 6135712; PMCID: PMC1129233.
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PubMed Mentions:
113 Fields:
Translation:
Animals
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Myocyte hypertrophy in neonatal rat heart cultures and its regulation by serum and by catecholamines. Circ Res. 1982 Dec; 51(6):787-801.
Simpson P, McGrath A, Savion S. PMID: 6216022.
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92 Fields:
Translation:
AnimalsCells
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Differentiation of rat myocytes in single cell cultures with and without proliferating nonmyocardial cells. Cross-striations, ultrastructure, and chronotropic response to isoproterenol. Circ Res. 1982 Jan; 50(1):101-16.
Simpson P, Savion S. PMID: 7053872.
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PubMed Mentions:
115 Fields:
Translation:
AnimalsCells
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Computed tomography: a new method for diagnosing tumor of the heart. Circulation. 1981 Feb; 63(2):448-51.
Godwin JD, Axel L, Adams JR, Schiller NB, Simpson PC, Gertz EW. PMID: 7449067.
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PubMed Mentions:
12 Fields:
Translation:
Humans
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Regulation of acetylcholine release from neuroblastoma x glioma hybrid cells. Proc Natl Acad Sci U S A. 1978 Mar; 75(3):1314-8.
McGee R, Simpson P, Christian C, Mata M, Nelson P, Nirenberg M. PMID: 206894; PMCID: PMC411461.
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PubMed Mentions:
29 Fields:
Translation:
Cells
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scyllo-inositol and myo-inositol levels in tissues of the skate Raja erinacea. Comp Biochem Physiol B. 1978; 59(3):201-2.
Sherman WR, Simpson PC, Goodwin SL. PMID: 318234.
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PubMed Mentions: Fields:
Translation:
Animals
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Effect of cyanide and electrical stimulation on phosphoinositide metabolism in lobster nerves. J Neurochem. 1971 Jul; 18(7):1291-8.
Birnberger AC, Birnberger KL, Eliasson SG, Simpson PC. PMID: 4330289.
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PubMed Mentions:
4 Fields:
Translation:
Animals
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The identification of myo-inosose-2 and scyllo-inositol in mammalian tissues. Biochemistry. 1968 Feb; 7(2):819-24.
Sherman WR, Stewart MA, Simpson PC, Goodwin SL. PMID: 5644141.
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PubMed Mentions:
2 Fields:
Translation:
AnimalsCells