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    Donald Ganem, MD

    Address513 Parnassus Ave
    San Francisco CA 94143
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      Collapse Biography 
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      University of California, San FranciscoResidency School of Medicine

      Collapse ORNG Applications 
      Collapse Global Health

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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Tropberger P, Mercier A, Robinson M, Zhong W, Ganem DE, Holdorf M. Mapping of histone modifications in episomal HBV cccDNA uncovers an unusual chromatin organization amenable to epigenetic manipulation. Proc Natl Acad Sci U S A. 2015 Oct 20; 112(42):E5715-24.
        View in: PubMed
      2. Bellare P, Dufresne A, Ganem D. Inefficient Codon Usage Impairs mRNA Accumulation: the Case of the v-FLIP Gene of Kaposi's Sarcoma-Associated Herpesvirus. J Virol. 2015 Jul 15; 89(14):7097-107.
        View in: PubMed
      3. Mercier A, Arias C, Madrid AS, Holdorf MM, Ganem D. Site-specific association with host and viral chromatin by Kaposi's sarcoma-associated herpesvirus LANA and its reversal during lytic reactivation. J Virol. 2014 Jun; 88(12):6762-77.
        View in: PubMed PMC4054346
      4. Ganem D, Neill US. A conversation with Don Ganem. J Clin Invest. 2014 Feb 3; 124(2):464-5.
        View in: PubMed PMC3904632
      5. Arias C, Weisburd B, Stern-Ginossar N, Mercier A, Madrid AS, Bellare P, Holdorf M, Weissman JS, Ganem D. KSHV 2.0: a comprehensive annotation of the Kaposi's sarcoma-associated herpesvirus genome using next-generation sequencing reveals novel genomic and functional features. PLoS Pathog. 2014 Jan; 10(1):e1003847.
        View in: PubMed PMC3894221
      6. Chang HH, Ganem D. A unique herpesviral transcriptional program in KSHV-infected lymphatic endothelial cells leads to mTORC1 activation and rapamycin sensitivity. Cell Host Microbe. 2013 Apr 17; 13(4):429-40.
        View in: PubMed PMC3774835
      7. Chandriani S, Skewes-Cox P, Zhong W, Ganem DE, Divers TJ, Van Blaricum AJ, Tennant BC, Kistler AL. Identification of a previously undescribed divergent virus from the Flaviviridae family in an outbreak of equine serum hepatitis. Proc Natl Acad Sci U S A. 2013 Apr 9; 110(15):E1407-15.
        View in: PubMed PMC3625295
      8. St├╝rzl M, Gaus D, Dirks WG, Ganem D, Jochmann R. Kaposi's sarcoma-derived cell line SLK is not of endothelial origin, but is a contaminant from a known renal carcinoma cell line. Int J Cancer. 2013 Apr 15; 132(8):1954-8.
        View in: PubMed
      9. Stenglein MD, Velazquez E, Greenacre C, Wilkes RP, Ruby JG, Lankton JS, Ganem D, Kennedy MA, DeRisi JL. Complete genome sequence of an astrovirus identified in a domestic rabbit (Oryctolagus cuniculus) with gastroenteritis. Virol J. 2012; 9:216.
        View in: PubMed PMC3502403
      10. Lee D, Das Gupta J, Gaughan C, Steffen I, Tang N, Luk KC, Qiu X, Urisman A, Fischer N, Molinaro R, Broz M, Schochetman G, Klein EA, Ganem D, Derisi JL, Simmons G, Hackett J, Silverman RH, Chiu CY. In-depth investigation of archival and prospectively collected samples reveals no evidence for XMRV infection in prostate cancer. PLoS One. 2012; 7(9):e44954.
        View in: PubMed PMC3445615
      11. Brulois KF, Chang H, Lee AS, Ensser A, Wong LY, Toth Z, Lee SH, Lee HR, Myoung J, Ganem D, Oh TK, Kim JF, Gao SJ, Jung JU. Construction and manipulation of a new Kaposi's sarcoma-associated herpesvirus bacterial artificial chromosome clone. J Virol. 2012 Sep; 86(18):9708-20.
        View in: PubMed PMC3446615
      12. Madrid AS, Ganem D. Kaposi's sarcoma-associated herpesvirus ORF54/dUTPase downregulates a ligand for the NK activating receptor NKp44. J Virol. 2012 Aug; 86(16):8693-704.
        View in: PubMed PMC3421743
      13. Austgen K, Oakes SA, Ganem D. Multiple defects, including premature apoptosis, prevent Kaposi's sarcoma-associated herpesvirus replication in murine cells. J Virol. 2012 Feb; 86(3):1877-82.
        View in: PubMed PMC3264352
      14. Myoung J, Ganem D. Infection of lymphoblastoid cell lines by Kaposi's sarcoma-associated herpesvirus: critical role of cell-associated virus. J Virol. 2011 Oct; 85(19):9767-77.
        View in: PubMed PMC3196463
      15. Runckel C, Flenniken ML, Engel JC, Ruby JG, Ganem D, Andino R, DeRisi JL. Temporal analysis of the honey bee microbiome reveals four novel viruses and seasonal prevalence of known viruses, Nosema, and Crithidia. PLoS One. 2011; 6(6):e20656.
        View in: PubMed PMC3110205
      16. Arron ST, Ruby JG, Dybbro E, Ganem D, Derisi JL. Transcriptome sequencing demonstrates that human papillomavirus is not active in cutaneous squamous cell carcinoma. J Invest Dermatol. 2011 Aug; 131(8):1745-53.
        View in: PubMed PMC3136639
      17. Myoung J, Ganem D. Generation of a doxycycline-inducible KSHV producer cell line of endothelial origin: maintenance of tight latency with efficient reactivation upon induction. J Virol Methods. 2011 Jun; 174(1-2):12-21.
        View in: PubMed PMC3095772
      18. Lin HR, Ganem D. Viral microRNA target allows insight into the role of translation in governing microRNA target accessibility. Proc Natl Acad Sci U S A. 2011 Mar 29; 108(13):5148-53.
        View in: PubMed PMC3069182
      19. Myoung J, Ganem D. Infection of primary human tonsillar lymphoid cells by KSHV reveals frequent but abortive infection of T cells. Virology. 2011 Apr 25; 413(1):1-11.
        View in: PubMed PMC3070441
      20. Wootton SC, Kim DS, Kondoh Y, Chen E, Lee JS, Song JW, Huh JW, Taniguchi H, Chiu C, Boushey H, Lancaster LH, Wolters PJ, DeRisi J, Ganem D, Collard HR. Viral infection in acute exacerbation of idiopathic pulmonary fibrosis. Am J Respir Crit Care Med. 2011 Jun 15; 183(12):1698-702.
        View in: PubMed PMC3136996
      21. Myoung J, Ganem D. Active lytic infection of human primary tonsillar B cells by KSHV and its noncytolytic control by activated CD4+ T cells. J Clin Invest. 2011 Mar; 121(3):1130-40.
        View in: PubMed PMC3049404
      22. Greninger AL, Holtz L, Kang G, Ganem D, Wang D, DeRisi JL. Serological evidence of human klassevirus infection. Clin Vaccine Immunol. 2010 Oct; 17(10):1584-8.
        View in: PubMed PMC2952992
      23. Speck SH, Ganem D. Viral latency and its regulation: lessons from the gamma-herpesviruses. Cell Host Microbe. 2010 Jul 22; 8(1):100-15.
        View in: PubMed PMC2914632
      24. Raghav R, Taylor M, Delay J, Ojkic D, Pearl DL, Kistler AL, Derisi JL, Ganem D, Smith DA. Avian bornavirus is present in many tissues of psittacine birds with histopathologic evidence of proventricular dilatation disease. J Vet Diagn Invest. 2010 Jul; 22(4):495-508.
        View in: PubMed
      25. Yozwiak NL, Skewes-Cox P, Gordon A, Saborio S, Kuan G, Balmaseda A, Ganem D, Harris E, DeRisi JL. Human enterovirus 109: a novel interspecies recombinant enterovirus isolated from a case of acute pediatric respiratory illness in Nicaragua. J Virol. 2010 Sep; 84(18):9047-58.
        View in: PubMed PMC2937614
      26. Chandriani S, Xu Y, Ganem D. The lytic transcriptome of Kaposi's sarcoma-associated herpesvirus reveals extensive transcription of noncoding regions, including regions antisense to important genes. J Virol. 2010 Aug; 84(16):7934-42.
        View in: PubMed PMC2916530
      27. Ganem D, Kistler A, DeRisi J. Achalasia and viral infection: new insights from veterinary medicine. Sci Transl Med. 2010 May 26; 2(33):33ps24.
        View in: PubMed
      28. Ganem D. KSHV and the pathogenesis of Kaposi sarcoma: listening to human biology and medicine. J Clin Invest. 2010 Apr; 120(4):939-49.
        View in: PubMed PMC2847423
      29. Xu Y, Ganem D. Making sense of antisense: seemingly noncoding RNAs antisense to the master regulator of Kaposi's sarcoma-associated herpesvirus lytic replication do not regulate that transcript but serve as mRNAs encoding small peptides. J Virol. 2010 Jun; 84(11):5465-75.
        View in: PubMed PMC2876621
      30. Chandriani S, Ganem D. Array-based transcript profiling and limiting-dilution reverse transcription-PCR analysis identify additional latent genes in Kaposi's sarcoma-associated herpesvirus. J Virol. 2010 Jun; 84(11):5565-73.
        View in: PubMed PMC2876603
      31. Chiu CY, Greninger AL, Chen EC, Haggerty TD, Parsonnet J, Delwart E, Derisi JL, Ganem D. Cultivation and serological characterization of a human Theiler's-like cardiovirus associated with diarrheal disease. J Virol. 2010 May; 84(9):4407-14.
        View in: PubMed PMC2863762
      32. Bellare P, Ganem D. Regulation of KSHV lytic switch protein expression by a virus-encoded microRNA: an evolutionary adaptation that fine-tunes lytic reactivation. Cell Host Microbe. 2009 Dec 17; 6(6):570-5.
        View in: PubMed PMC2822622
      33. Kistler AL, Smith JM, Greninger AL, Derisi JL, Ganem D. Analysis of naturally occurring avian bornavirus infection and transmission during an outbreak of proventricular dilatation disease among captive psittacine birds. J Virol. 2010 Feb; 84(4):2176-9.
        View in: PubMed PMC2812378
      34. Gancz AY, Kistler AL, Greninger AL, Farnoushi Y, Mechani S, Perl S, Berkowitz A, Perez N, Clubb S, DeRisi JL, Ganem D, Lublin A. Experimental induction of proventricular dilatation disease in cockatiels (Nymphicus hollandicus) inoculated with brain homogenates containing avian bornavirus 4. Virol J. 2009; 6:100.
        View in: PubMed PMC2717941
      35. Greninger AL, Runckel C, Chiu CY, Haggerty T, Parsonnet J, Ganem D, DeRisi JL. The complete genome of klassevirus - a novel picornavirus in pediatric stool. Virol J. 2009; 6:82.
        View in: PubMed PMC2709156
      36. Bisson SA, Page AL, Ganem D. A Kaposi's sarcoma-associated herpesvirus protein that forms inhibitory complexes with type I interferon receptor subunits, Jak and STAT proteins, and blocks interferon-mediated signal transduction. J Virol. 2009 May; 83(10):5056-66.
        View in: PubMed PMC2682077
      37. Sullivan CS, Sung CK, Pack CD, Grundhoff A, Lukacher AE, Benjamin TL, Ganem D. Murine Polyomavirus encodes a microRNA that cleaves early RNA transcripts but is not essential for experimental infection. Virology. 2009 Apr 25; 387(1):157-67.
        View in: PubMed PMC2722155
      38. Ziegelbauer JM, Sullivan CS, Ganem D. Tandem array-based expression screens identify host mRNA targets of virus-encoded microRNAs. Nat Genet. 2009 Jan; 41(1):130-4.
        View in: PubMed PMC2749995
      39. Ganem D, Ziegelbauer J. MicroRNAs of Kaposi's sarcoma-associated herpes virus. Semin Cancer Biol. 2008 Dec; 18(6):437-40.
        View in: PubMed
      40. Chiu CY, Greninger AL, Kanada K, Kwok T, Fischer KF, Runckel C, Louie JK, Glaser CA, Yagi S, Schnurr DP, Haggerty TD, Parsonnet J, Ganem D, DeRisi JL. Identification of cardioviruses related to Theiler's murine encephalomyelitis virus in human infections. Proc Natl Acad Sci U S A. 2008 Sep 16; 105(37):14124-9.
        View in: PubMed PMC2528868
      41. Kistler AL, Gancz A, Clubb S, Skewes-Cox P, Fischer K, Sorber K, Chiu CY, Lublin A, Mechani S, Farnoushi Y, Greninger A, Wen CC, Karlene SB, Ganem D, DeRisi JL. Recovery of divergent avian bornaviruses from cases of proventricular dilatation disease: identification of a candidate etiologic agent. Virol J. 2008; 5:88.
        View in: PubMed PMC2546392
      42. Chiu CY, Urisman A, Greenhow TL, Rouskin S, Yagi S, Schnurr D, Wright C, Drew WL, Wang D, Weintrub PS, Derisi JL, Ganem D. Utility of DNA microarrays for detection of viruses in acute respiratory tract infections in children. J Pediatr. 2008 Jul; 153(1):76-83.
        View in: PubMed PMC3174048
      43. Grossmann C, Ganem D. Effects of NFkappaB activation on KSHV latency and lytic reactivation are complex and context-dependent. Virology. 2008 May 25; 375(1):94-102.
        View in: PubMed PMC2822626
      44. Chandriani S, Ganem D. Host transcript accumulation during lytic KSHV infection reveals several classes of host responses. PLoS One. 2007; 2(8):e811.
        View in: PubMed PMC1950738
      45. Kistler A, Avila PC, Rouskin S, Wang D, Ward T, Yagi S, Schnurr D, Ganem D, DeRisi JL, Boushey HA. Pan-viral screening of respiratory tract infections in adults with and without asthma reveals unexpected human coronavirus and human rhinovirus diversity. J Infect Dis. 2007 Sep 15; 196(6):817-25.
        View in: PubMed
      46. Chiu CY, Alizadeh AA, Rouskin S, Merker JD, Yeh E, Yagi S, Schnurr D, Patterson BK, Ganem D, DeRisi JL. Diagnosis of a critical respiratory illness caused by human metapneumovirus by use of a pan-virus microarray. J Clin Microbiol. 2007 Jul; 45(7):2340-3.
        View in: PubMed PMC1933008
      47. Rowe M, Glaunsinger B, van Leeuwen D, Zuo J, Sweetman D, Ganem D, Middeldorp J, Wiertz EJ, Ressing ME. Host shutoff during productive Epstein-Barr virus infection is mediated by BGLF5 and may contribute to immune evasion. Proc Natl Acad Sci U S A. 2007 Feb 27; 104(9):3366-71.
        View in: PubMed PMC1805610
      48. Dong B, Kim S, Hong S, Das Gupta J, Malathi K, Klein EA, Ganem D, Derisi JL, Chow SA, Silverman RH. An infectious retrovirus susceptible to an IFN antiviral pathway from human prostate tumors. Proc Natl Acad Sci U S A. 2007 Jan 30; 104(5):1655-60.
        View in: PubMed PMC1776164
      49. Xu Y, Ganem D. Induction of chemokine production by latent Kaposi's sarcoma-associated herpesvirus infection of endothelial cells. J Gen Virol. 2007 Jan; 88(Pt 1):46-50.
        View in: PubMed
      50. Chiu CY, Rouskin S, Koshy A, Urisman A, Fischer K, Yagi S, Schnurr D, Eckburg PB, Tompkins LS, Blackburn BG, Merker JD, Patterson BK, Ganem D, DeRisi JL. Microarray detection of human parainfluenzavirus 4 infection associated with respiratory failure in an immunocompetent adult. Clin Infect Dis. 2006 Oct 15; 43(8):e71-6.
        View in: PubMed
      51. Grossmann C, Podgrabinska S, Skobe M, Ganem D. Activation of NF-kappaB by the latent vFLIP gene of Kaposi's sarcoma-associated herpesvirus is required for the spindle shape of virus-infected endothelial cells and contributes to their proinflammatory phenotype. J Virol. 2006 Jul; 80(14):7179-85.
        View in: PubMed PMC1489050
      52. McCormick C, Ganem D. Phosphorylation and function of the kaposin B direct repeats of Kaposi's sarcoma-associated herpesvirus. J Virol. 2006 Jun; 80(12):6165-70.
        View in: PubMed PMC1472581
      53. Urisman A, Molinaro RJ, Fischer N, Plummer SJ, Casey G, Klein EA, Malathi K, Magi-Galluzzi C, Tubbs RR, Ganem D, Silverman RH, DeRisi JL. Identification of a novel Gammaretrovirus in prostate tumors of patients homozygous for R462Q RNASEL variant. PLoS Pathog. 2006 Mar; 2(3):e25.
        View in: PubMed PMC1434790
      54. Grundhoff A, Sullivan CS, Ganem D. A combined computational and microarray-based approach identifies novel microRNAs encoded by human gamma-herpesviruses. RNA. 2006 May; 12(5):733-50.
        View in: PubMed PMC1440911
      55. Ziegelbauer J, Grundhoff A, Ganem D. Exploring the DNA binding interactions of the Kaposi's sarcoma-associated herpesvirus lytic switch protein by selective amplification of bound sequences in vitro. J Virol. 2006 Mar; 80(6):2958-67.
        View in: PubMed PMC1395432
      56. Ganem D. KSHV infection and the pathogenesis of Kaposi's sarcoma. Annu Rev Pathol. 2006; 1:273-96.
        View in: PubMed
      57. Sullivan CS, Grundhoff A, Tevethia S, Treisman R, Pipas JM, Ganem D. Expression and function of microRNAs in viruses great and small. Cold Spring Harb Symp Quant Biol. 2006; 71:351-6.
        View in: PubMed
      58. Glaunsinger BA, Ganem DE. Messenger RNA turnover and its regulation in herpesviral infection. Adv Virus Res. 2006; 66:337-94.
        View in: PubMed
      59. Sullivan CS, Ganem D. MicroRNAs and viral infection. Mol Cell. 2005 Oct 7; 20(1):3-7.
        View in: PubMed
      60. Bechtel J, Grundhoff A, Ganem D. RNAs in the virion of Kaposi's sarcoma-associated herpesvirus. J Virol. 2005 Aug; 79(16):10138-46.
        View in: PubMed PMC1182685
      61. Sullivan CS, Grundhoff AT, Tevethia S, Pipas JM, Ganem D. SV40-encoded microRNAs regulate viral gene expression and reduce susceptibility to cytotoxic T cells. Nature. 2005 Jun 2; 435(7042):682-6.
        View in: PubMed
      62. Sullivan CS, Ganem D. A virus-encoded inhibitor that blocks RNA interference in mammalian cells. J Virol. 2005 Jun; 79(12):7371-9.
        View in: PubMed PMC1143619
      63. Glaunsinger B, Chavez L, Ganem D. The exonuclease and host shutoff functions of the SOX protein of Kaposi's sarcoma-associated herpesvirus are genetically separable. J Virol. 2005 Jun; 79(12):7396-401.
        View in: PubMed PMC1143623
      64. Sanchez DJ, Gumperz JE, Ganem D. Regulation of CD1d expression and function by a herpesvirus infection. J Clin Invest. 2005 May; 115(5):1369-78.
        View in: PubMed PMC1087176
      65. Bechtel JT, Winant RC, Ganem D. Host and viral proteins in the virion of Kaposi's sarcoma-associated herpesvirus. J Virol. 2005 Apr; 79(8):4952-64.
        View in: PubMed PMC1069574
      66. McCormick C, Ganem D. The kaposin B protein of KSHV activates the p38/MK2 pathway and stabilizes cytokine mRNAs. Science. 2005 Feb 4; 307(5710):739-41.
        View in: PubMed
      67. Glaunsinger B, Ganem D. Highly selective escape from KSHV-mediated host mRNA shutoff and its implications for viral pathogenesis. J Exp Med. 2004 Aug 2; 200(3):391-8.
        View in: PubMed PMC2211977
      68. Liang Y, Ganem D. RBP-J (CSL) is essential for activation of the K14/vGPCR promoter of Kaposi's sarcoma-associated herpesvirus by the lytic switch protein RTA. J Virol. 2004 Jul; 78(13):6818-26.
        View in: PubMed PMC421686
      69. Glaunsinger B, Ganem D. Lytic KSHV infection inhibits host gene expression by accelerating global mRNA turnover. Mol Cell. 2004 Mar 12; 13(5):713-23.
        View in: PubMed
      70. Ganem D, Prince AM. Hepatitis B virus infection--natural history and clinical consequences. N Engl J Med. 2004 Mar 11; 350(11):1118-29.
        View in: PubMed
      71. Renne R, Dittmer D, Kedes D, Schmidt K, Desrosiers RC, Luciw PA, Ganem D. Experimental transmission of Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) to SIV-positive and SIV-negative rhesus macaques. J Med Primatol. 2004 Feb; 33(1):1-9.
        View in: PubMed
      72. Grundhoff A, Ganem D. Inefficient establishment of KSHV latency suggests an additional role for continued lytic replication in Kaposi sarcoma pathogenesis. J Clin Invest. 2004 Jan; 113(1):124-36.
        View in: PubMed PMC300762
      73. Wang D, Urisman A, Liu YT, Springer M, Ksiazek TG, Erdman DD, Mardis ER, Hickenbotham M, Magrini V, Eldred J, Latreille JP, Wilson RK, Ganem D, DeRisi JL. Viral discovery and sequence recovery using DNA microarrays. PLoS Biol. 2003 Nov; 1(2):E2.
        View in: PubMed PMC261870
      74. Liang Y, Ganem D. Lytic but not latent infection by Kaposi's sarcoma-associated herpesvirus requires host CSL protein, the mediator of Notch signaling. Proc Natl Acad Sci U S A. 2003 Jul 8; 100(14):8490-5.
        View in: PubMed PMC166256
      75. Bechtel JT, Liang Y, Hvidding J, Ganem D. Host range of Kaposi's sarcoma-associated herpesvirus in cultured cells. J Virol. 2003 Jun; 77(11):6474-81.
        View in: PubMed PMC155009
      76. Grundhoff A, Ganem D. The latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus permits replication of terminal repeat-containing plasmids. J Virol. 2003 Feb; 77(4):2779-83.
        View in: PubMed PMC141125
      77. Coscoy L, Ganem D. PHD domains and E3 ubiquitin ligases: viruses make the connection. Trends Cell Biol. 2003 Jan; 13(1):7-12.
        View in: PubMed
      78. Wang D, Coscoy L, Zylberberg M, Avila PC, Boushey HA, Ganem D, DeRisi JL. Microarray-based detection and genotyping of viral pathogens. Proc Natl Acad Sci U S A. 2002 Nov 26; 99(24):15687-92.
        View in: PubMed PMC137777
      79. Polson AG, Wang D, DeRisi J, Ganem D. Modulation of host gene expression by the constitutively active G protein-coupled receptor of Kaposi's sarcoma-associated herpesvirus. Cancer Res. 2002 Aug 1; 62(15):4525-30.
        View in: PubMed
      80. Liang Y, Chang J, Lynch SJ, Lukac DM, Ganem D. The lytic switch protein of KSHV activates gene expression via functional interaction with RBP-Jkappa (CSL), the target of the Notch signaling pathway. Genes Dev. 2002 Aug 1; 16(15):1977-89.
        View in: PubMed PMC186409
      81. Baron JL, Gardiner L, Nishimura S, Shinkai K, Locksley R, Ganem D. Activation of a nonclassical NKT cell subset in a transgenic mouse model of hepatitis B virus infection. Immunity. 2002 Apr; 16(4):583-94.
        View in: PubMed
      82. Lagunoff M, Bechtel J, Venetsanakos E, Roy AM, Abbey N, Herndier B, McMahon M, Ganem D. De novo infection and serial transmission of Kaposi's sarcoma-associated herpesvirus in cultured endothelial cells. J Virol. 2002 Mar; 76(5):2440-8.
        View in: PubMed PMC153827
      83. Coscoy L, Sanchez DJ, Ganem D. A novel class of herpesvirus-encoded membrane-bound E3 ubiquitin ligases regulates endocytosis of proteins involved in immune recognition. J Cell Biol. 2001 Dec 24; 155(7):1265-73.
        View in: PubMed PMC2199318
      84. Sanchez DJ, Coscoy L, Ganem D. Functional organization of MIR2, a novel viral regulator of selective endocytosis. J Biol Chem. 2002 Feb 22; 277(8):6124-30.
        View in: PubMed
      85. Ganem D. Virology. The X files--one step closer to closure. Science. 2001 Dec 14; 294(5550):2299-300.
        View in: PubMed
      86. Lukac DM, Garibyan L, Kirshner JR, Palmeri D, Ganem D. DNA binding by Kaposi's sarcoma-associated herpesvirus lytic switch protein is necessary for transcriptional activation of two viral delayed early promoters. J Virol. 2001 Aug; 75(15):6786-99.
        View in: PubMed PMC114405
      87. Liu YT, Brazas R, Ganem D. Efficient hepatitis delta virus RNA replication in avian cells requires a permissive factor(s) from mammalian cells. J Virol. 2001 Aug; 75(16):7489-93.
        View in: PubMed PMC114984
      88. Lagunoff M, Lukac DM, Ganem D. Immunoreceptor tyrosine-based activation motif-dependent signaling by Kaposi's sarcoma-associated herpesvirus K1 protein: effects on lytic viral replication. J Virol. 2001 Jul; 75(13):5891-8.
        View in: PubMed PMC114304
      89. Brander C, O'Connor P, Suscovich T, Jones NG, Lee Y, Kedes D, Ganem D, Martin J, Osmond D, Southwood S, Sette A, Walker BD, Scadden DT. Definition of an optimal cytotoxic T lymphocyte epitope in the latently expressed Kaposi's sarcoma-associated herpesvirus kaposin protein. J Infect Dis. 2001 Jul 15; 184(2):119-26.
        View in: PubMed
      90. Coscoy L, Ganem D. A viral protein that selectively downregulates ICAM-1 and B7-2 and modulates T cell costimulation. J Clin Invest. 2001 Jun; 107(12):1599-606.
        View in: PubMed PMC200195
      91. Polson AG, Huang L, Lukac DM, Blethrow JD, Morgan DO, Burlingame AL, Ganem D. Kaposi's sarcoma-associated herpesvirus K-bZIP protein is phosphorylated by cyclin-dependent kinases. J Virol. 2001 Apr; 75(7):3175-84.
        View in: PubMed PMC114111
      92. Wang D, Pearlberg J, Liu YT, Ganem D. Deleterious effects of hepatitis delta virus replication on host cell proliferation. J Virol. 2001 Apr; 75(8):3600-4.
        View in: PubMed PMC114851
      93. Grundhoff A, Ganem D. Mechanisms governing expression of the v-FLIP gene of Kaposi's sarcoma-associated herpesvirus. J Virol. 2001 Feb; 75(4):1857-63.
        View in: PubMed PMC114095
      94. Herndier B, Ganem D. The biology of Kaposi's sarcoma. Cancer Treat Res. 2001; 104:89-126.
        View in: PubMed
      95. Renne R, Barry C, Dittmer D, Compitello N, Brown PO, Ganem D. Modulation of cellular and viral gene expression by the latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus. J Virol. 2001 Jan; 75(1):458-68.
        View in: PubMed PMC113938
      96. Wu L, Renne R, Ganem D, Forghani B. Human herpesvirus 8 glycoprotein K8.1: expression, post-translational modification and localization analyzed by monoclonal antibody. J Clin Virol. 2000 Aug; 17(2):127-36.
        View in: PubMed
      97. Chang J, Ganem D. On the control of late gene expression in Kaposi's sarcoma-associated herpesvirus (human herpesvirus-8). J Gen Virol. 2000 Aug; 81(Pt 8):2039-47.
        View in: PubMed
      98. Coscoy L, Ganem D. Kaposi's sarcoma-associated herpesvirus encodes two proteins that block cell surface display of MHC class I chains by enhancing their endocytosis. Proc Natl Acad Sci U S A. 2000 Jul 5; 97(14):8051-6.
        View in: PubMed PMC16668
      99. Bell P, Brazas R, Ganem D, Maul GG. Hepatitis delta virus replication generates complexes of large hepatitis delta antigen and antigenomic RNA that affiliate with and alter nuclear domain 10. J Virol. 2000 Jun; 74(11):5329-36.
        View in: PubMed PMC110888
      100. Kirshner JR, Lukac DM, Chang J, Ganem D. Kaposi's sarcoma-associated herpesvirus open reading frame 57 encodes a posttranscriptional regulator with multiple distinct activities. J Virol. 2000 Apr; 74(8):3586-97.
        View in: PubMed PMC111868
      101. Chang J, Renne R, Dittmer D, Ganem D. Inflammatory cytokines and the reactivation of Kaposi's sarcoma-associated herpesvirus lytic replication. Virology. 2000 Jan 5; 266(1):17-25.
        View in: PubMed
      102. Dittmer D, Stoddart C, Renne R, Linquist-Stepps V, Moreno ME, Bare C, McCune JM, Ganem D. Experimental transmission of Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) to SCID-hu Thy/Liv mice. J Exp Med. 1999 Dec 20; 190(12):1857-68.
        View in: PubMed PMC2195708
      103. Lukac DM, Kirshner JR, Ganem D. Transcriptional activation by the product of open reading frame 50 of Kaposi's sarcoma-associated herpesvirus is required for lytic viral reactivation in B cells. J Virol. 1999 Nov; 73(11):9348-61.
        View in: PubMed PMC112969
      104. Ganem D. An advance in liver-specific gene delivery. Proc Natl Acad Sci U S A. 1999 Oct 12; 96(21):11696-7.
        View in: PubMed PMC33791
      105. O'Brien TR, Kedes D, Ganem D, Macrae DR, Rosenberg PS, Molden J, Goedert JJ. Evidence for concurrent epidemics of human herpesvirus 8 and human immunodeficiency virus type 1 in US homosexual men: rates, risk factors, and relationship to Kaposi's sarcoma. J Infect Dis. 1999 Oct; 180(4):1010-7.
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      106. Kirshner JR, Staskus K, Haase A, Lagunoff M, Ganem D. Expression of the open reading frame 74 (G-protein-coupled receptor) gene of Kaposi's sarcoma (KS)-associated herpesvirus: implications for KS pathogenesis. J Virol. 1999 Jul; 73(7):6006-14.
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      107. Sadler R, Wu L, Forghani B, Renne R, Zhong W, Herndier B, Ganem D. A complex translational program generates multiple novel proteins from the latently expressed kaposin (K12) locus of Kaposi's sarcoma-associated herpesvirus. J Virol. 1999 Jul; 73(7):5722-30.
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      108. Lagunoff M, Majeti R, Weiss A, Ganem D. Deregulated signal transduction by the K1 gene product of Kaposi's sarcoma-associated herpesvirus. Proc Natl Acad Sci U S A. 1999 May 11; 96(10):5704-9.
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      109. Lukac DM, Renne R, Kirshner JR, Ganem D. Reactivation of Kaposi's sarcoma-associated herpesvirus infection from latency by expression of the ORF 50 transactivator, a homolog of the EBV R protein. Virology. 1998 Dec 20; 252(2):304-12.
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      110. Blower S, Ganem D. Mathematicians turn their attention to hepatitis C. Nat Med. 1998 Nov; 4(11):1233-4.
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      111. Dittmer D, Lagunoff M, Renne R, Staskus K, Haase A, Ganem D. A cluster of latently expressed genes in Kaposi's sarcoma-associated herpesvirus. J Virol. 1998 Oct; 72(10):8309-15.
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      112. Ganem D. Towards a rational therapy for hepatitis B. J Clin Invest. 1998 Sep 1; 102(5):867-8.
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      113. Wei Y, Tennant B, Ganem D. In vivo effects of mutations in woodchuck hepatitis virus enhancer II. J Virol. 1998 Aug; 72(8):6608-13.
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      114. Renne R, Blackbourn D, Whitby D, Levy J, Ganem D. Limited transmission of Kaposi's sarcoma-associated herpesvirus in cultured cells. J Virol. 1998 Jun; 72(6):5182-8.
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      115. Eng FJ, Novikova EG, Kuroki K, Ganem D, Fricker LD. gp180, a protein that binds duck hepatitis B virus particles, has metallocarboxypeptidase D-like enzymatic activity. J Biol Chem. 1998 Apr 3; 273(14):8382-8.
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      116. Martin JN, Ganem DE, Osmond DH, Page-Shafer KA, Macrae D, Kedes DH. Sexual transmission and the natural history of human herpesvirus 8 infection. N Engl J Med. 1998 Apr 2; 338(14):948-54.
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      117. Wei Y, Ganem D. Activation of heterologous gene expression by the large isoform of hepatitis delta antigen. J Virol. 1998 Mar; 72(3):2089-96.
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      118. Ganem D. Human herpesvirus 8 and its role in the genesis of Kaposi's sarcoma. Curr Clin Top Infect Dis. 1998; 18:237-51.
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      119. Kedes DH, Lagunoff M, Renne R, Ganem D. Identification of the gene encoding the major latency-associated nuclear antigen of the Kaposi's sarcoma-associated herpesvirus. J Clin Invest. 1997 Nov 15; 100(10):2606-10.
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      120. Perri S, Ganem D. Effects of mutations within and adjacent to the terminal repeats of hepatitis B virus pregenomic RNA on viral DNA synthesis. J Virol. 1997 Nov; 71(11):8448-55.
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      121. Ganem D. KSHV and Kaposi's sarcoma: the end of the beginning? Cell. 1997 Oct 17; 91(2):157-60.
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      122. Lagunoff M, Ganem D. The structure and coding organization of the genomic termini of Kaposi's sarcoma-associated herpesvirus. Virology. 1997 Sep 15; 236(1):147-54.
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      123. Unal A, Pray TR, Lagunoff M, Pennington MW, Ganem D, Craik CS. The protease and the assembly protein of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8). J Virol. 1997 Sep; 71(9):7030-8.
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      124. Diamond C, Huang ML, Kedes DH, Speck C, Rankin GW, Ganem D, Coombs RW, Rose TM, Krieger JN, Corey L. Absence of detectable human herpesvirus 8 in the semen of human immunodeficiency virus-infected men without Kaposi's sarcoma. J Infect Dis. 1997 Sep; 176(3):775-7.
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      125. Goedert JJ, Kedes DH, Ganem D. Antibodies to human herpesvirus 8 in women and infants born in Haiti and the USA. Lancet. 1997 May 10; 349(9062):1368.
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      126. Kedes DH, Ganem D. Sensitivity of Kaposi's sarcoma-associated herpesvirus replication to antiviral drugs. Implications for potential therapy. J Clin Invest. 1997 May 1; 99(9):2082-6.
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      127. Orenstein JM, Alkan S, Blauvelt A, Jeang KT, Weinstein MD, Ganem D, Herndier B. Visualization of human herpesvirus type 8 in Kaposi's sarcoma by light and transmission electron microscopy. AIDS. 1997 Apr; 11(5):F35-45.
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      128. Kedes DH, Ganem D, Ameli N, Bacchetti P, Greenblatt R. The prevalence of serum antibody to human herpesvirus 8 (Kaposi sarcoma-associated herpesvirus) among HIV-seropositive and high-risk HIV-seronegative women. JAMA. 1997 Feb 12; 277(6):478-81.
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      129. Zhong W, Ganem D. Characterization of ribonucleoprotein complexes containing an abundant polyadenylated nuclear RNA encoded by Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8). J Virol. 1997 Feb; 71(2):1207-12.
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      130. Staskus KA, Zhong W, Gebhard K, Herndier B, Wang H, Renne R, Beneke J, Pudney J, Anderson DJ, Ganem D, Haase AT. Kaposi's sarcoma-associated herpesvirus gene expression in endothelial (spindle) tumor cells. J Virol. 1997 Jan; 71(1):715-9.
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      131. Renne R, Lagunoff M, Zhong W, Ganem D. The size and conformation of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) DNA in infected cells and virions. J Virol. 1996 Nov; 70(11):8151-4.
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      132. Brazas R, Ganem D. A cellular homolog of hepatitis delta antigen: implications for viral replication and evolution. Science. 1996 Oct 4; 274(5284):90-4.
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      133. Perri S, Ganem D. A host factor that binds near the termini of hepatitis B virus pregenomic RNA. J Virol. 1996 Oct; 70(10):6803-9.
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      134. Wei Y, Tavis JE, Ganem D. Relationship between viral DNA synthesis and virion envelopment in hepatitis B viruses. J Virol. 1996 Sep; 70(9):6455-8.
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      135. Tavis JE, Ganem D. Evidence for activation of the hepatitis B virus polymerase by binding of its RNA template. J Virol. 1996 Sep; 70(9):5741-50.
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      136. Kedes DH, Operskalski E, Busch M, Kohn R, Flood J, Ganem D. The seroepidemiology of human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus): distribution of infection in KS risk groups and evidence for sexual transmission. Nat Med. 1996 Aug; 2(8):918-24.
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      137. Ueda K, Wei Y, Ganem D. Cellular factors controlling the activity of woodchuck hepatitis virus enhancer II. J Virol. 1996 Jul; 70(7):4714-23.
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      138. Zhong W, Wang H, Herndier B, Ganem D. Restricted expression of Kaposi sarcoma-associated herpesvirus (human herpesvirus 8) genes in Kaposi sarcoma. Proc Natl Acad Sci U S A. 1996 Jun 25; 93(13):6641-6.
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      139. Ziermann R, Ganem D. Homologous and heterologous complementation of HBV and WHV capsid and polymerase functions in RNA encapsidation. Virology. 1996 May 15; 219(2):350-6.
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      140. Renne R, Zhong W, Herndier B, McGrath M, Abbey N, Kedes D, Ganem D. Lytic growth of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in culture. Nat Med. 1996 Mar; 2(3):342-6.
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      141. Ueda K, Wei Y, Ganem D. Activation of N-myc2 gene expression by cis-acting elements of oncogenic hepadnaviral genomes: key role of enhancer II. Virology. 1996 Mar 1; 217(1):413-7.
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      142. Ueda K, Ganem D. Apoptosis is induced by N-myc expression in hepatocytes, a frequent event in hepadnavirus oncogenesis, and is blocked by insulin-like growth factor II. J Virol. 1996 Mar; 70(3):1375-83.
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      143. Chuck S, Grant RM, Katongole-Mbidde E, Conant M, Ganem D. Frequent presence of a novel herpesvirus genome in lesions of human immunodeficiency virus-negative Kaposi's sarcoma. J Infect Dis. 1996 Jan; 173(1):248-51.
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      144. Ishikawa T, Ganem D. The pre-S domain of the large viral envelope protein determines host range in avian hepatitis B viruses. Proc Natl Acad Sci U S A. 1995 Jul 3; 92(14):6259-63.
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      145. Tavis JE, Ganem D. RNA sequences controlling the initiation and transfer of duck hepatitis B virus minus-strand DNA. J Virol. 1995 Jul; 69(7):4283-91.
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      146. Kuroki K, Eng F, Ishikawa T, Turck C, Harada F, Ganem D. gp180, a host cell glycoprotein that binds duck hepatitis B virus particles, is encoded by a member of the carboxypeptidase gene family. J Biol Chem. 1995 Jun 23; 270(25):15022-8.
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      147. Ganem D. AIDS. Viruses, cytokines and Kaposi's sarcoma. Curr Biol. 1995 May 1; 5(5):469-71.
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      148. Chang C, Hirsch RC, Ganem D. Sequences in the preC region of duck hepatitis B virus affect pregenomic RNA accumulation. Virology. 1995 Mar 10; 207(2):549-54.
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      149. Pollack JR, Ganem D. Site-specific RNA binding by a hepatitis B virus reverse transcriptase initiates two distinct reactions: RNA packaging and DNA synthesis. J Virol. 1994 Sep; 68(9):5579-87.
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      150. Chang C, Zhou S, Ganem D, Standring DN. Phenotypic mixing between different hepadnavirus nucleocapsid proteins reveals C protein dimerization to be cis preferential. J Virol. 1994 Aug; 68(8):5225-31.
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      151. Ishikawa T, Kuroki K, Lenhoff R, Summers J, Ganem D. Analysis of the binding of a host cell surface glycoprotein to the preS protein of duck hepatitis B virus. Virology. 1994 Aug 1; 202(2):1061-4.
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      152. Tavis JE, Perri S, Ganem D. Hepadnavirus reverse transcription initiates within the stem-loop of the RNA packaging signal and employs a novel strand transfer. J Virol. 1994 Jun; 68(6):3536-43.
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      153. Kuroki K, Cheung R, Marion PL, Ganem D. A cell surface protein that binds avian hepatitis B virus particles. J Virol. 1994 Apr; 68(4):2091-6.
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      154. Ganem D, Pollack JR, Tavis J. Hepatitis B virus reverse transcriptase and its many roles in hepadnaviral genomic replication. Infect Agents Dis. 1994 Apr-Jun; 3(2-3):85-93.
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      155. Lingappa JR, Martin RL, Wong ML, Ganem D, Welch WJ, Lingappa VR. A eukaryotic cytosolic chaperonin is associated with a high molecular weight intermediate in the assembly of hepatitis B virus capsid, a multimeric particle. J Cell Biol. 1994 Apr; 125(1):99-111.
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      156. Ostapchuk P, Hearing P, Ganem D. A dramatic shift in the transmembrane topology of a viral envelope glycoprotein accompanies hepatitis B viral morphogenesis. EMBO J. 1994 Mar 1; 13(5):1048-57.
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      157. Tan M, Klein R, Grant R, Ganem D, Engel J. Cloning and characterization of the RNA polymerase alpha-subunit operon of Chlamydia trachomatis. J Bacteriol. 1993 Nov; 175(22):7150-9.
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      158. Pollack JR, Ganem D. An RNA stem-loop structure directs hepatitis B virus genomic RNA encapsidation. J Virol. 1993 Jun; 67(6):3254-63.
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      159. Tavis JE, Ganem D. Expression of functional hepatitis B virus polymerase in yeast reveals it to be the sole viral protein required for correct initiation of reverse transcription. Proc Natl Acad Sci U S A. 1993 May 1; 90(9):4107-11.
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      160. Lavine JE, Ganem D. Inhibition of duck hepatitis B virus replication by interferon-gamma. J Med Virol. 1993 May; 40(1):59-64.
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      161. Hansen LJ, Tennant BC, Seeger C, Ganem D. Differential activation of myc gene family members in hepatic carcinogenesis by closely related hepatitis B viruses. Mol Cell Biol. 1993 Jan; 13(1):659-67.
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      162. Cherrington J, Russnak R, Ganem D. Upstream sequences and cap proximity in the regulation of polyadenylation in ground squirrel hepatitis virus. J Virol. 1992 Dec; 66(12):7589-96.
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      163. Cherrington J, Ganem D. Regulation of polyadenylation in human immunodeficiency virus (HIV): contributions of promoter proximity and upstream sequences. EMBO J. 1992 Apr; 11(4):1513-24.
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      164. Perara E, Ganem D, Engel JN. A developmentally regulated chlamydial gene with apparent homology to eukaryotic histone H1. Proc Natl Acad Sci U S A. 1992 Mar 15; 89(6):2125-9.
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      165. Loeb DD, Hirsch RC, Ganem D. Sequence-independent RNA cleavages generate the primers for plus strand DNA synthesis in hepatitis B viruses: implications for other reverse transcribing elements. EMBO J. 1991 Nov; 10(11):3533-40.
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      166. Bruss V, Ganem D. Mutational analysis of hepatitis B surface antigen particle assembly and secretion. J Virol. 1991 Jul; 65(7):3813-20.
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      167. Hirsch RC, Loeb DD, Pollack JR, Ganem D. cis-acting sequences required for encapsidation of duck hepatitis B virus pregenomic RNA. J Virol. 1991 Jun; 65(6):3309-16.
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      168. Seeger C, Baldwin B, Hornbuckle WE, Yeager AE, Tennant BC, Cote P, Ferrell L, Ganem D, Varmus HE. Woodchuck hepatitis virus is a more efficient oncogenic agent than ground squirrel hepatitis virus in a common host. J Virol. 1991 Apr; 65(4):1673-9.
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      169. Macrae DR, Bruss V, Ganem D. Myristylation of a duck hepatitis B virus envelope protein is essential for infectivity but not for virus assembly. Virology. 1991 Mar; 181(1):359-63.
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      170. Staprans S, Loeb DD, Ganem D. Mutations affecting hepadnavirus plus-strand DNA synthesis dissociate primer cleavage from translocation and reveal the origin of linear viral DNA. J Virol. 1991 Mar; 65(3):1255-62.
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      171. Bruss V, Ganem D. The role of envelope proteins in hepatitis B virus assembly. Proc Natl Acad Sci U S A. 1991 Feb 1; 88(3):1059-63.
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      172. Lavine JE, Lake JR, Ascher NL, Ferrell LD, Ganem D, Wright TL. Persistent hepatitis B virus following interferon alfa therapy and liver transplantation. Gastroenterology. 1991 Jan; 100(1):263-7.
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      173. Ganem D. Assembly of hepadnaviral virions and subviral particles. Curr Top Microbiol Immunol. 1991; 168:61-83.
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      174. Engel JN, Pollack J, Perara E, Ganem D. Heat shock response of murine Chlamydia trachomatis. J Bacteriol. 1990 Dec; 172(12):6959-72.
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      175. Perara E, Yen TS, Ganem D. Growth of Chlamydia trachomatis in enucleated cells. Infect Immun. 1990 Nov; 58(11):3816-8.
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      176. Chang LJ, Hirsch RC, Ganem D, Varmus HE. Effects of insertional and point mutations on the functions of the duck hepatitis B virus polymerase. J Virol. 1990 Nov; 64(11):5553-8.
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      177. Engel JN, Pollack J, Malik F, Ganem D. Cloning and characterization of RNA polymerase core subunits of Chlamydia trachomatis by using the polymerase chain reaction. J Bacteriol. 1990 Oct; 172(10):5732-41.
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      178. Ganem D. Oncogenic viruses. Of marmots and men. Nature. 1990 Sep 20; 347(6290):230-2.
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      179. Chang LJ, Ganem D, Varmus HE. Mechanism of translation of the hepadnaviral polymerase (P) gene. Proc Natl Acad Sci U S A. 1990 Jul; 87(13):5158-62.
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      180. Kuroki K, Floreani M, Mimms LT, Ganem D. Epitope mapping of the PreS1 domain of the hepatitis B virus large surface protein. Virology. 1990 Jun; 176(2):620-4.
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      181. Engel JN, Ganem D. A polymerase chain reaction-based approach to cloning sigma factors from eubacteria and its application to the isolation of a sigma-70 homolog from Chlamydia trachomatis. J Bacteriol. 1990 May; 172(5):2447-55.
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      182. Russnak R, Ganem D. Sequences 5' to the polyadenylation signal mediate differential poly(A) site use in hepatitis B viruses. Genes Dev. 1990 May; 4(5):764-76.
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      183. Hirsch RC, Lavine JE, Chang LJ, Varmus HE, Ganem D. Polymerase gene products of hepatitis B viruses are required for genomic RNA packaging as wel as for reverse transcription. Nature. 1990 Apr 5; 344(6266):552-5.
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      184. Eble BE, Lingappa VR, Ganem D. The N-terminal (pre-S2) domain of a hepatitis B virus surface glycoprotein is translocated across membranes by downstream signal sequences. J Virol. 1990 Mar; 64(3):1414-9.
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      185. Lavine J, Hirsch R, Ganem D. A system for studying the selective encapsidation of hepadnavirus RNA. J Virol. 1989 Oct; 63(10):4257-63.
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      186. Kuroki K, Russnak R, Ganem D. Novel N-terminal amino acid sequence required for retention of a hepatitis B virus glycoprotein in the endoplasmic reticulum. Mol Cell Biol. 1989 Oct; 9(10):4459-66.
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      187. Chang LJ, Dienstag J, Ganem D, Varmus H. Detection of antibodies against hepatitis B virus polymerase antigen in hepatitis B virus-infected patients. Hepatology. 1989 Sep; 10(3):332-5.
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      188. Colgrove R, Simon G, Ganem D. Transcriptional activation of homologous and heterologous genes by the hepatitis B virus X gene product in cells permissive for viral replication. J Virol. 1989 Sep; 63(9):4019-26.
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      189. Chang LJ, Pryciak P, Ganem D, Varmus HE. Biosynthesis of the reverse transcriptase of hepatitis B viruses involves de novo translational initiation not ribosomal frameshifting. Nature. 1989 Jan 26; 337(6205):364-8.
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      190. Sardinia LM, Engel JN, Ganem D. Chlamydial gene encoding a 70-kilodalton antigen in Escherichia coli: analysis of expression signals and identification of the gene product. J Bacteriol. 1989 Jan; 171(1):335-41.
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      191. Wright TL, Ganem D. The polyalbumin hypothesis: where is it in 1989? Gastroenterology. 1989 Jan; 96(1):250-2.
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      192. Simon K, Lingappa VR, Ganem D. Secreted hepatitis B surface antigen polypeptides are derived from a transmembrane precursor. J Cell Biol. 1988 Dec; 107(6 Pt 1):2163-8.
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      193. Hirsch R, Colgrove R, Ganem D. Replication of duck hepatitis B virus in two differentiated human hepatoma cell lines after transfection with cloned viral DNA. Virology. 1988 Nov; 167(1):136-42.
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      194. Simon K, Lingappa VR, Ganem D. A block to the intracellular transport and assembly of hepatitis B surface antigen polypeptides in Xenopus oocytes. Virology. 1988 Sep; 166(1):76-81.
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      195. Sardinia LM, Segal E, Ganem D. Developmental regulation of the cysteine-rich outer-membrane proteins of murine Chlamydia trachomatis. J Gen Microbiol. 1988 Apr; 134(4):997-1004.
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      196. Engel JN, Ganem D. Chlamydial rRNA operons: gene organization and identification of putative tandem promoters. J Bacteriol. 1987 Dec; 169(12):5678-85.
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      197. Eble BE, MacRae DR, Lingappa VR, Ganem D. Multiple topogenic sequences determine the transmembrane orientation of the hepatitis B surface antigen. Mol Cell Biol. 1987 Oct; 7(10):3591-601.
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      198. Seeger C, Marion PL, Ganem D, Varmus HE. In vitro recombinants of ground squirrel and woodchuck hepatitis viral DNAs produce infectious virus in squirrels. J Virol. 1987 Oct; 61(10):3241-7.
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      199. Chang C, Enders G, Sprengel R, Peters N, Varmus HE, Ganem D. Expression of the precore region of an avian hepatitis B virus is not required for viral replication. J Virol. 1987 Oct; 61(10):3322-5.
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      200. Sprengel R, Varmus HE, Ganem D. Homologous recombination between hepadnaviral genomes following in vivo DNA transfection: implications for studies of viral infectivity. Virology. 1987 Aug; 159(2):454-6.
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      201. Persing DH, Varmus HE, Ganem D. The preS1 protein of hepatitis B virus is acylated at its amino terminus with myristic acid. J Virol. 1987 May; 61(5):1672-7.
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      202. Ganem D, Varmus HE. The molecular biology of the hepatitis B viruses. Annu Rev Biochem. 1987; 56:651-93.
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      203. Enders GH, Ganem D, Varmus HE. 5'-terminal sequences influence the segregation of ground squirrel hepatitis virus RNAs into polyribosomes and viral core particles. J Virol. 1987 Jan; 61(1):35-41.
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      204. Persing DH, Varmus HE, Ganem D. Inhibition of secretion of hepatitis B surface antigen by a related presurface polypeptide. Science. 1986 Dec 12; 234(4782):1388-91.
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      205. Persing DH, Varmus HE, Ganem D. Antibodies to pre-S and X determinants arise during natural infection with ground squirrel hepatitis virus. J Virol. 1986 Oct; 60(1):177-84.
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      206. Eble BE, Lingappa VR, Ganem D. Hepatitis B surface antigen: an unusual secreted protein initially synthesized as a transmembrane polypeptide. Mol Cell Biol. 1986 May; 6(5):1454-63.
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      207. Seeger C, Ganem D, Varmus HE. Biochemical and genetic evidence for the hepatitis B virus replication strategy. Science. 1986 Apr 25; 232(4749):477-84.
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      208. Ganem D. Extrahepatic hepadnavirus DNA: what does it mean? Gastroenterology. 1985 Dec; 89(6):1429-30.
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      209. Enders GH, Ganem D, Varmus H. Mapping the major transcripts of ground squirrel hepatitis virus: the presumptive template for reverse transcriptase is terminally redundant. Cell. 1985 Aug; 42(1):297-308.
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      210. Trueba D, Phelan M, Nelson J, Beck F, Pecha BS, Brown RJ, Varmus HE, Ganem D. Transmission of ground squirrel hepatitis virus to homologous and heterologous hosts. Hepatology. 1985 May-Jun; 5(3):435-9.
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      211. Persing DH, Varmus HE, Ganem D. A frameshift mutation in the pre-S region of the human hepatitis B virus genome allows production of surface antigen particles but eliminates binding to polymerized albumin. Proc Natl Acad Sci U S A. 1985 May; 82(10):3440-4.
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      212. Seeger C, Ganem D, Varmus HE. The cloned genome of ground squirrel hepatitis virus is infectious in the animal. Proc Natl Acad Sci U S A. 1984 Sep; 81(18):5849-52.
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      213. Seeger C, Ganem D, Varmus HE. Nucleotide sequence of an infectious molecularly cloned genome of ground squirrel hepatitis virus. J Virol. 1984 Aug; 51(2):367-75.
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      214. Standring DN, Rutter WJ, Varmus HE, Ganem D. Transcription of the hepatitis B surface antigen gene in cultured murine cells initiates within the presurface region. J Virol. 1984 May; 50(2):563-71.
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      215. Weiser B, Ganem D, Seeger C, Varmus HE. Closed circular viral DNA and asymmetrical heterogeneous forms in livers from animals infected with ground squirrel hepatitis virus. J Virol. 1983 Oct; 48(1):1-9.
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      216. Ganem D, Vyas GN. Laboratory diagnosis of viral hepatitis. Geriatrics. 1983 Mar; 38(3):97-103, 107-8.
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      217. Ganem D, Weiser B, Barchuk A, Brown RJ, Varmus HE. Biological characterization of acute infection with ground squirrel hepatitis virus. J Virol. 1982 Oct; 44(1):366-73.
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      218. Ganem D, Greenbaum L, Varmus HE. Virion DNA of ground squirrel hepatitis virus: structural analysis and molecular cloning. J Virol. 1982 Oct; 44(1):374-83.
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      219. Ganem D. Persistent infection of humans with hepatitis B virus: mechanisms and consequences. Rev Infect Dis. 1982 Sep-Oct; 4(5):1026-47.
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      220. Schmeissner U, Ganem D, Miller JH. Revised gene-protein map for the lacI gene-lac repressor system. J Mol Biol. 1977 Dec 15; 117(3):572-5.
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      221. Davoli D, Ganem D, Nussbaum AL, Fareed G, Howley PM, Khoury G, Martin MA. Genome Structures of reiteration mutants of simian virus 40. Virology. 1977 Mar; 77(1):110-24.
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      222. Schmeissner U, Ganem D, Miller JH. Genetic studies of the lac repressor. II. Fine structure deletion map of the lacI gene, and its correlation with the physical map. J Mol Biol. 1977 Jan 15; 109(2):303-26.
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      223. Miller JH, Ganem D, Lu P, Schmitz A. Genetic studies of the lac repressor. I. Correlation of mutational sites with specific amino acid residues: construction of a colinear gene-protein map. J Mol Biol. 1977 Jan 15; 109(2):275-98.
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      224. Nussbaum AL, Davoli D, Ganem D, Fareed GC. Construction and propagation of a defective simian virus 40 genome bearing an operator from bacteriophage lambda. Proc Natl Acad Sci U S A. 1976 Apr; 73(4):1068-72.
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      225. Sebban C, Ganem D. [Thoughts on endodontic disinfection: are there several methods]. Inf Dent. 1976 Mar 18; 58(12):37-42.
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      226. Ganem D, Nussbaum AL, Davoli D, Fareed GC. Propagation of a segment of bacteriophage lamda-DNA in monkey cells after covalent linkage to a defective simian virus 40 genome. Cell. 1976 Mar; 7(3):349-59.
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