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Jonathan Weissman, PhD

Address1700 4th St
San Francisco CA 94158
Phone415-502-7642
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    Collapse Research 
    Collapse Research Activities and Funding
    Harnessing CRISPR for Targeted and Inducible Epigenomic Reprogramming
    NIH/NIDA R01DA036858Sep 30, 2013 - May 31, 2018
    Role: Co-Principal Investigator
    Structural Basis of Protein Homeostasis
    NIH/NIGMS U01GM098254Sep 30, 2012 - Jul 31, 2015
    Role: Co-Principal Investigator
    Human Gene Knockdowns that May Extend Lifespan
    NIH/NIA R01AG041826May 1, 2012 - Apr 30, 2017
    Role: Principal Investigator
    Bay Area Cancer Target Discovery and Development Network
    NIH/NCI U01CA168370May 1, 2012 - Apr 30, 2017
    Role: Co-Principal Investigator
    MECHANISM OF CHAPERONE MEDIATED PROTEIN FOLDING
    NIH/NIGMS R01GM055595May 1, 1997 - Apr 30, 2002
    Role: Principal Investigator
    Molecular Pathogenesis of Age-Dependent CNS Regeneration
    NIH/NIA P01AG010770Apr 1, 1993 - Mar 31, 2016
    Role: Co-Investigator
    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator

    Collapse ORNG Applications 
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    Collapse In The News
    Collapse Global Health

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Sendoel A, Dunn JG, Rodriguez EH, Naik S, Gomez NC, Hurwitz B, Levorse J, Dill BD, Schramek D, Molina H, Weissman J, Fuchs E. Translation from unconventional 5' start sites drives tumour initiation. Nature. 2017 Jan 11. PMID: 28077873.
      View in: PubMed
    2. Liu SJ, Horlbeck MA, Cho SW, Birk HS, Malatesta M, He D, Attenello FJ, Villalta JE, Cho MY, Chen Y, Mandegar MA, Olvera MP, Gilbert LA, Conklin BR, Chang HY, Weissman J, Lim DA. CRISPRi-based genome-scale identification of functional long noncoding RNA loci in human cells. Science. 2016 Dec 15. PMID: 27980086.
      View in: PubMed
    3. Dixit A, Parnas O, Li B, Chen J, Fulco CP, Jerby-Arnon L, Marjanovic ND, Dionne D, Burks T, Raychowdhury R, Adamson B, Norman TM, Lander ES, Weissman J, Friedman N, Regev A. Perturb-Seq: Dissecting Molecular Circuits with Scalable Single-Cell RNA Profiling of Pooled Genetic Screens. Cell. 2016 Dec 15; 167(7):1853-1866.e17. PMID: 27984732.
      View in: PubMed
    4. Adamson B, Norman TM, Jost M, Cho MY, Nuñez JK, Chen Y, Villalta JE, Gilbert LA, Horlbeck MA, Hein MY, Pak RA, Gray AN, Gross CA, Dixit A, Parnas O, Regev A, Weissman J. A Multiplexed Single-Cell CRISPR Screening Platform Enables Systematic Dissection of the Unfolded Protein Response. Cell. 2016 Dec 15; 167(7):1867-1882.e21. PMID: 27984733.
      View in: PubMed
    5. Besnard E, Hakre S, Kampmann M, Lim HW, Hosmane NN, Martin A, Bassik MC, Verschueren E, Battivelli E, Chan J, Svensson JP, Gramatica A, Conrad RJ, Ott M, Greene WC, Krogan NJ, Siliciano RF, Weissman J, Verdin E. The mTOR Complex Controls HIV Latency. Cell Host Microbe. 2016 Dec 14; 20(6):785-797. PMID: 27978436.
      View in: PubMed
    6. Dunn JG, Weissman J. Plastid: nucleotide-resolution analysis of next-generation sequencing and genomics data. BMC Genomics. 2016 Nov 22; 17(1):958. PMID: 27875984.
      View in: PubMed
    7. Stewart-Ornstein J, Chen S, Bhatnagar R, Weissman J, El-Samad H. Model-guided optogenetic study of PKA signaling in budding yeast. Mol Biol Cell. 2017 Jan 01; 28(1):221-227. PMID: 28035051.
      View in: PubMed
    8. Zubradt M, Gupta P, Persad S, Lambowitz AM, Weissman J, Rouskin S. DMS-MaPseq for genome-wide or targeted RNA structure probing in vivo. Nat Methods. 2016 Nov 07. PMID: 27819661.
      View in: PubMed
    9. Schrader JM, Li GW, Childers WS, Perez AM, Weissman J, Shapiro L, McAdams HH. Dynamic translation regulation in Caulobacter cell cycle control. Proc Natl Acad Sci U S A. 2016 Nov 1; 113(44):E6859-E6867. PMID: 27791168.
      View in: PubMed
    10. Horlbeck MA, Gilbert LA, Villalta JE, Adamson B, Pak RA, Chen Y, Fields AP, Park CY, Corn JE, Kampmann M, Weissman J. Compact and highly active next-generation libraries for CRISPR-mediated gene repression and activation. Elife. 2016 Sep 23; 5. PMID: 27661255.
      View in: PubMed
    11. Sabnis AJ, Guerriero CJ, Olivas V, Sayana A, Shue J, Flanagan J, Asthana S, Paton AW, Paton JC, Gestwicki JE, Walter P, Weissman J, Wipf P, Brodsky JL, Bivona TG. Combined chemical-genetic approach identifies cytosolic HSP70 dependence in rhabdomyosarcoma. Proc Natl Acad Sci U S A. 2016 Aug 9; 113(32):9015-20. PMID: 27450084.
      View in: PubMed
    12. Nguyen DP, Miyaoka Y, Gilbert LA, Mayerl SJ, Lee BH, Weissman J, Conklin BR, Wells JA. Ligand-binding domains of nuclear receptors facilitate tight control of split CRISPR activity. Nat Commun. 2016; 7:12009. PMID: 27363581.
      View in: PubMed
    13. Liu YC, Fujimori DG, Weissman J. Htm1p-Pdi1p is a folding-sensitive mannosidase that marks N-glycoproteins for ER-associated protein degradation. Proc Natl Acad Sci U S A. 2016 Jul 12; 113(28):E4015-24. PMID: 27357682.
      View in: PubMed
    14. Braun CJ, Bruno PM, Horlbeck MA, Gilbert LA, Weissman J, Hemann MT. Versatile in vivo regulation of tumor phenotypes by dCas9-mediated transcriptional perturbation. Proc Natl Acad Sci U S A. 2016 Jul 5; 113(27):E3892-900. PMID: 27325776.
      View in: PubMed
    15. Leonetti MD, Sekine S, Kamiyama D, Weissman J, Huang B, et al. A scalable strategy for high-throughput GFP tagging of endogenous human proteins. Proc Natl Acad Sci U S A. 2016 Jun 21; 113(25):E3501-8. PMID: 27274053.
      View in: PubMed
    16. Peters JM, Colavin A, Shi H, Czarny TL, Larson MH, Wong S, Hawkins JS, Lu CH, Koo BM, Marta E, Shiver AL, Whitehead EH, Weissman J, Brown ED, Qi LS, Huang KC, Gross CA. A Comprehensive, CRISPR-based Functional Analysis of Essential Genes in Bacteria. Cell. 2016 Jun 2; 165(6):1493-506. PMID: 27238023.
      View in: PubMed
    17. Liu SJ, Nowakowski TJ, Pollen AA, Lui JH, Horlbeck MA, Attenello FJ, He D, Weissman J, Kriegstein AR, Diaz AA, Lim DA. Single-cell analysis of long non-coding RNAs in the developing human neocortex. Genome Biol. 2016; 17(1):67. PMID: 27081004.
      View in: PubMed
    18. Kamiyama D, Sekine S, Barsi-Rhyne B, Hu J, Chen B, Gilbert LA, Ishikawa H, Leonetti MD, Marshall WF, Weissman J, Huang B. Versatile protein tagging in cells with split fluorescent protein. Nat Commun. 2016; 7:11046. PMID: 26988139.
      View in: PubMed
    19. Horlbeck MA, Witkowsky LB, Guglielmi B, Replogle JM, Gilbert LA, Villalta JE, Torigoe SE, Tjian R, Weissman J. Nucleosomes impede Cas9 access to DNA in vivo and in vitro. Elife. 2016; 5. PMID: 26987018.
      View in: PubMed
    20. Mandegar MA, Huebsch N, Frolov EB, Shin E, Truong A, Olvera MP, Chan AH, Miyaoka Y, Holmes K, Spencer CI, Judge LM, Gordon DE, Eskildsen TV, Villalta JE, Horlbeck MA, Gilbert LA, Krogan NJ, Sheikh SP, Weissman J, Qi LS, So PL, Conklin BR. CRISPR Interference Efficiently Induces Specific and Reversible Gene Silencing in Human iPSCs. Cell Stem Cell. 2016 Apr 7; 18(4):541-53. PMID: 26971820.
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    21. Fields AP, Rodriguez EH, Jovanovic M, Stern-Ginossar N, Haas BJ, Mertins P, Raychowdhury R, Hacohen N, Carr SA, Ingolia NT, Regev A, Weissman J. A Regression-Based Analysis of Ribosome-Profiling Data Reveals a Conserved Complexity to Mammalian Translation. Mol Cell. 2015 Dec 3; 60(5):816-27. PMID: 26638175.
      View in: PubMed
    22. Suzuki G, Weissman J, Tanaka M. [KIL-d] Protein Element Confers Antiviral Activity via Catastrophic Viral Mutagenesis. Mol Cell. 2015 Nov 19; 60(4):651-60. PMID: 26590718.
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    23. Anderson DJ, Le Moigne R, Djakovic S, Kumar B, Rice J, Wong S, Wang J, Yao B, Valle E, Kiss von Soly S, Madriaga A, Soriano F, Menon MK, Wu ZY, Kampmann M, Chen Y, Weissman J, Aftab BT, Yakes FM, Shawver L, Zhou HJ, Wustrow D, Rolfe M. Targeting the AAA ATPase p97 as an Approach to Treat Cancer through Disruption of Protein Homeostasis. Cancer Cell. 2015 Nov 9; 28(5):653-65. PMID: 26555175.
      View in: PubMed
    24. Brar GA, Weissman J. Ribosome profiling reveals the what, when, where and how of protein synthesis. Nat Rev Mol Cell Biol. 2015 Nov; 16(11):651-64. PMID: 26465719.
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    25. Acosta-Alvear D, Cho MY, Wild T, Buchholz TJ, Lerner AG, Simakova O, Hahn J, Korde N, Landgren O, Maric I, Choudhary C, Walter P, Weissman J, Kampmann M. Paradoxical resistance of multiple myeloma to proteasome inhibitors by decreased levels of 19S proteasomal subunits. Elife. 2015; 4. PMID: 26327694; PMCID: PMC4602331.
    26. Tanenbaum ME, Stern-Ginossar N, Weissman J, Vale RD. Regulation of mRNA translation during mitosis. Elife. 2015; 4. PMID: 26305499; PMCID: PMC4548207.
    27. Kampmann M, Horlbeck MA, Chen Y, Tsai JC, Bassik MC, Gilbert LA, Villalta JE, Kwon SC, Chang H, Kim VN, Weissman J. Next-generation libraries for robust RNA interference-based genome-wide screens. Proc Natl Acad Sci U S A. 2015 Jun 30; 112(26):E3384-91. PMID: 26080438; PMCID: PMC4491794 [Available on 12/30/15].
    28. Jan CH, Williams CC, Weissman J. LOCAL TRANSLATION. Response to Comment on "Principles of ER cotranslational translocation revealed by proximity-specific ribosome profiling". Science. 2015 Jun 12; 348(6240):1217. PMID: 26068842.
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    29. Pazarentzos E, Giannikopoulos P, Hrustanovic G, St John J, Olivas VR, Gubens MA, Balassanian R, Weissman J, Polkinghorn W, Bivona TG. Oncogenic activation of the PI3-kinase p110ß isoform via the tumor-derived PIK3Cß(D1067V) kinase domain mutation. Oncogene. 2016 Mar 3; 35(9):1198-205. PMID: 25982275.
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    30. Sidrauski C, Tsai JC, Kampmann M, Hearn BR, Vedantham P, Jaishankar P, Sokabe M, Mendez AS, Newton BW, Tang EL, Verschueren E, Johnson JR, Krogan NJ, Fraser CS, Weissman J, Renslo AR, Walter P. Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response. Elife. 2015; 4:e07314. PMID: 25875391; PMCID: PMC4426669.
    31. Kampmann M, Bassik MC, Weissman J. Corrigendum: functional genomics platform for pooled screening and generation of mammalian genetic interaction maps. Nat Protoc. 2015 Apr; 10(4):643. PMID: 25811902.
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    32. Baltimore D, Berg P, Botchan M, Carroll D, Charo RA, Church G, Corn JE, Daley GQ, Doudna JA, Fenner M, Greely HT, Jinek M, Martin GS, Penhoet E, Puck J, Sternberg SH, Weissman J, Yamamoto KR. Biotechnology. A prudent path forward for genomic engineering and germline gene modification. Science. 2015 Apr 3; 348(6230):36-8. PMID: 25791083; PMCID: PMC4394183.
    33. Jovanovic M, Rooney MS, Mertins P, Przybylski D, Chevrier N, Satija R, Rodriguez EH, Fields AP, Schwartz S, Raychowdhury R, Mumbach MR, Eisenhaure T, Rabani M, Gennert D, Lu D, Delorey T, Weissman J, Carr SA, Hacohen N, Regev A. Immunogenetics. Dynamic profiling of the protein life cycle in response to pathogens. Science. 2015 Mar 6; 347(6226):1259038. PMID: 25745177; PMCID: PMC4506746 [Available on 03/06/16].
    34. Li X, Colvin T, Rauch JN, Acosta-Alvear D, Kampmann M, Dunyak B, Hann B, Aftab BT, Murnane M, Cho M, Walter P, Weissman J, Sherman MY, Gestwicki JE. Validation of the Hsp70-Bag3 protein-protein interaction as a potential therapeutic target in cancer. Mol Cancer Ther. 2015 Mar; 14(3):642-8. PMID: 25564440; PMCID: PMC4456214 [Available on 03/01/16].
    35. Shen PS, Park J, Qin Y, Li X, Parsawar K, Larson MH, Cox J, Cheng Y, Lambowitz AM, Weissman J, Brandman O, Frost A. Protein synthesis. Rqc2p and 60S ribosomal subunits mediate mRNA-independent elongation of nascent chains. Science. 2015 Jan 2; 347(6217):75-8. PMID: 25554787; PMCID: PMC4451101.
    36. Pop C, Rouskin S, Ingolia NT, Han L, Phizicky EM, Weissman J, Koller D. Causal signals between codon bias, mRNA structure, and the efficiency of translation and elongation. Mol Syst Biol. 2014; 10:770. PMID: 25538139; PMCID: PMC4300493.
    37. Zalatan JG, Lee ME, Almeida R, Gilbert LA, Whitehead EH, La Russa M, Tsai JC, Weissman J, Dueber JE, Qi LS, Lim WA. Engineering complex synthetic transcriptional programs with CRISPR RNA scaffolds. Cell. 2015 Jan 15; 160(1-2):339-50. PMID: 25533786; PMCID: PMC4297522 [Available on 01/15/16].
    38. Williams CC, Jan CH, Weissman J. Targeting and plasticity of mitochondrial proteins revealed by proximity-specific ribosome profiling. Science. 2014 Nov 7; 346(6210):748-51. PMID: 25378625; PMCID: PMC4263316.
    39. Jan CH, Williams CC, Weissman J. Principles of ER cotranslational translocation revealed by proximity-specific ribosome profiling. Science. 2014 Nov 7; 346(6210):1257521. PMID: 25378630; PMCID: PMC4285348.
    40. Kannan K, Kanabar P, Schryer D, Florin T, Oh E, Bahroos N, Tenson T, Weissman J, Mankin AS. The general mode of translation inhibition by macrolide antibiotics. Proc Natl Acad Sci U S A. 2014 Nov 11; 111(45):15958-63. PMID: 25349425; PMCID: PMC4234590.
    41. Albert FW, Muzzey D, Weissman J, Kruglyak L. Genetic influences on translation in yeast. PLoS Genet. 2014 Oct; 10(10):e1004692. PMID: 25340754; PMCID: PMC4207643.
    42. Gilbert LA, Horlbeck MA, Adamson B, Villalta JE, Chen Y, Whitehead EH, Guimaraes C, Panning B, Ploegh HL, Bassik MC, Qi LS, Kampmann M, Weissman J. Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation. Cell. 2014 Oct 23; 159(3):647-61. PMID: 25307932; PMCID: PMC4253859.
    43. Tanenbaum ME, Gilbert LA, Qi LS, Weissman J, Vale RD. A protein-tagging system for signal amplification in gene expression and fluorescence imaging. Cell. 2014 Oct 23; 159(3):635-46. PMID: 25307933; PMCID: PMC4252608.
    44. Julien O, Kampmann M, Bassik MC, Zorn JA, Venditto VJ, Shimbo K, Agard NJ, Shimada K, Rheingold AL, Stockwell BR, Weissman J, Wells JA. Unraveling the mechanism of cell death induced by chemical fibrils. Nat Chem Biol. 2014 Nov; 10(11):969-76. PMID: 25262416; PMCID: PMC4201873.
    45. Ingolia NT, Brar GA, Stern-Ginossar N, Harris MS, Talhouarne GJ, Jackson SE, Wills MR, Weissman J. Ribosome profiling reveals pervasive translation outside of annotated protein-coding genes. Cell Rep. 2014 Sep 11; 8(5):1365-79. PMID: 25159147; PMCID: PMC4216110.
    46. Smith MH, Rodriguez EH, Weissman J. Misfolded proteins induce aggregation of the lectin Yos9. J Biol Chem. 2014 Sep 12; 289(37):25670-7. PMID: 25086047; PMCID: PMC4162170.
    47. Schrader JM, Zhou B, Li GW, Lasker K, Childers WS, Williams B, Long T, Crosson S, McAdams HH, Weissman J, Shapiro L. The coding and noncoding architecture of the Caulobacter crescentus genome. PLoS Genet. 2014 Jul; 10(7):e1004463. PMID: 25078267; PMCID: PMC4117421.
    48. Kampmann M, Bassik MC, Weissman J. Functional genomics platform for pooled screening and generation of mammalian genetic interaction maps. Nat Protoc. 2014 Aug; 9(8):1825-47. PMID: 24992097; PMCID: PMC4144868.
    49. van de Weijer ML, Bassik MC, Luteijn RD, Voorburg CM, Lohuis MA, Kremmer E, Hoeben RC, LeProust EM, Chen S, Hoelen H, Ressing ME, Patena W, Weissman J, McManus MT, Wiertz EJ, Lebbink RJ. A high-coverage shRNA screen identifies TMEM129 as an E3 ligase involved in ER-associated protein degradation. Nat Commun. 2014; 5:3832. PMID: 24807418; PMCID: PMC4024746.
    50. Larson MH, Mooney RA, Peters JM, Windgassen T, Nayak D, Gross CA, Block SM, Greenleaf WJ, Landick R, Weissman J. A pause sequence enriched at translation start sites drives transcription dynamics in vivo. Science. 2014 May 30; 344(6187):1042-7. PMID: 24789973; PMCID: PMC4108260.
    51. Li GW, Burkhardt D, Gross C, Weissman J. Quantifying absolute protein synthesis rates reveals principles underlying allocation of cellular resources. Cell. 2014 Apr 24; 157(3):624-35. PMID: 24766808; PMCID: PMC4006352.
    52. Muzzey D, Sherlock G, Weissman J. Extensive and coordinated control of allele-specific expression by both transcription and translation in Candida albicans. Genome Res. 2014 Jun; 24(6):963-73. PMID: 24732588; PMCID: PMC4032860.
    53. Pfanner N, van der Laan M, Amati P, Capaldi RA, Caudy AA, Chacinska A, Darshi M, Deckers M, Hoppins S, Icho T, Jakobs S, Ji J, Kozjak-Pavlovic V, Meisinger C, Odgren PR, Park SK, Rehling P, Reichert AS, Sheikh MS, Taylor SS, Tsuchida N, van der Bliek AM, van der Klei IJ, Weissman J, Westermann B, Zha J, Neupert W, Nunnari J. Uniform nomenclature for the mitochondrial contact site and cristae organizing system. J Cell Biol. 2014 Mar 31; 204(7):1083-6. PMID: 24687277; PMCID: PMC3971754.
    54. Wolff S, Weissman J, Dillin A. Differential scales of protein quality control. Cell. 2014 Mar 27; 157(1):52-64. PMID: 24679526.
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    55. Arias C, Weisburd B, Stern-Ginossar N, Mercier A, Madrid AS, Bellare P, Holdorf M, Weissman J, Ganem D. KSHV 2.0: a comprehensive annotation of the Kaposi's sarcoma-associated herpesvirus genome using next-generation sequencing reveals novel genomic and functional features. PLoS Pathog. 2014 Jan; 10(1):e1003847. PMID: 24453964; PMCID: PMC3894221.
    56. Chen B, Gilbert LA, Cimini BA, Schnitzbauer J, Zhang W, Li GW, Park J, Blackburn EH, Weissman J, Qi LS, Huang B. Dynamic imaging of genomic loci in living human cells by an optimized CRISPR/Cas system. Cell. 2013 Dec 19; 155(7):1479-91. PMID: 24360272; PMCID: PMC3918502.
    57. Rouskin S, Zubradt M, Washietl S, Kellis M, Weissman J. Genome-wide probing of RNA structure reveals active unfolding of mRNA structures in vivo. Nature. 2014 Jan 30; 505(7485):701-5. PMID: 24336214; PMCID: PMC3966492.
    58. Dunn JG, Foo CK, Belletier NG, Gavis ER, Weissman J. Ribosome profiling reveals pervasive and regulated stop codon readthrough in Drosophila melanogaster. Elife. 2013; 2:e01179. PMID: 24302569; PMCID: PMC3840789.
    59. Stewart-Ornstein J, Nelson C, DeRisi J, Weissman J, El-Samad H. Msn2 coordinates a stoichiometric gene expression program. Curr Biol. 2013 Dec 2; 23(23):2336-45. PMID: 24210615; PMCID: PMC4072881.
    60. Matheny CJ, Wei MC, Bassik MC, Donnelly AJ, Kampmann M, Iwasaki M, Piloto O, Solow-Cordero DE, Bouley DM, Rau R, Brown P, McManus MT, Weissman J, Cleary ML. Next-generation NAMPT inhibitors identified by sequential high-throughput phenotypic chemical and functional genomic screens. Chem Biol. 2013 Nov 21; 20(11):1352-63. PMID: 24183972; PMCID: PMC3881547.
    61. Wiita AP, Ziv E, Wiita PJ, Urisman A, Julien O, Burlingame AL, Weissman J, Wells JA. Global cellular response to chemotherapy-induced apoptosis. Elife. 2013; 2:e01236. PMID: 24171104; PMCID: PMC3808542.
    62. Becker AH, Oh E, Weissman J, Kramer G, Bukau B. Selective ribosome profiling as a tool for studying the interaction of chaperones and targeting factors with nascent polypeptide chains and ribosomes. Nat Protoc. 2013 Nov; 8(11):2212-39. PMID: 24136347; PMCID: PMC4001812.
    63. Larson MH, Gilbert LA, Wang X, Lim WA, Weissman J, Qi LS. CRISPR interference (CRISPRi) for sequence-specific control of gene expression. Nat Protoc. 2013 Nov; 8(11):2180-96. PMID: 24136345; PMCID: PMC3922765.
    64. Berchowitz LE, Gajadhar AS, van Werven FJ, De Rosa AA, Samoylova ML, Brar GA, Xu Y, Xiao C, Futcher B, Weissman J, White FM, Amon A. A developmentally regulated translational control pathway establishes the meiotic chromosome segregation pattern. Genes Dev. 2013 Oct 1; 27(19):2147-63. PMID: 24115771; PMCID: PMC3850098.
    65. Gilbert LA, Larson MH, Morsut L, Liu Z, Brar GA, Torres SE, Stern-Ginossar N, Brandman O, Whitehead EH, Doudna JA, Lim WA, Weissman J, Qi LS. CRISPR-mediated modular RNA-guided regulation of transcription in eukaryotes. Cell. 2013 Jul 18; 154(2):442-51. PMID: 23849981; PMCID: PMC3770145.
    66. Ingolia NT, Brar GA, Rouskin S, McGeachy AM, Weissman J. Genome-wide annotation and quantitation of translation by ribosome profiling. Curr Protoc Mol Biol. 2013 Jul; Chapter 4:Unit 4.18. PMID: 23821443; PMCID: PMC3775365.
    67. Guttman M, Russell P, Ingolia NT, Weissman J, Lander ES. Ribosome profiling provides evidence that large noncoding RNAs do not encode proteins. Cell. 2013 Jul 3; 154(1):240-51. PMID: 23810193; PMCID: PMC3756563.
    68. Kampmann M, Bassik MC, Weissman J. Integrated platform for genome-wide screening and construction of high-density genetic interaction maps in mammalian cells. Proc Natl Acad Sci U S A. 2013 Jun 18; 110(25):E2317-26. PMID: 23739767; PMCID: PMC3690882.
    69. O'Connor PB, Li GW, Weissman J, Atkins JF, Baranov PV. rRNA:mRNA pairing alters the length and the symmetry of mRNA-protected fragments in ribosome profiling experiments. Bioinformatics. 2013 Jun 15; 29(12):1488-91. PMID: 23603333; PMCID: PMC3673220.
    70. Thorburn RR, Gonzalez C, Brar GA, Christen S, Carlile TM, Ingolia NT, Sauer U, Weissman J, Amon A. Aneuploid yeast strains exhibit defects in cell growth and passage through START. Mol Biol Cell. 2013 May; 24(9):1274-89. PMID: 23468524; PMCID: PMC3639041.
    71. Schuldiner M, Weissman J. The contribution of systematic approaches to characterizing the proteins and functions of the endoplasmic reticulum. Cold Spring Harb Perspect Biol. 2013 Mar; 5(3):a013284. PMID: 23359093; PMCID: PMC3578357.
    72. Qi LS, Larson MH, Gilbert LA, Doudna JA, Weissman J, Arkin AP, Lim WA. Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression. Cell. 2013 Feb 28; 152(5):1173-83. PMID: 23452860; PMCID: PMC3664290.
    73. Bassik MC, Kampmann M, Lebbink RJ, Wang S, Hein MY, Poser I, Weibezahn J, Horlbeck MA, Chen S, Mann M, Hyman AA, Leproust EM, McManus MT, Weissman J. A systematic mammalian genetic interaction map reveals pathways underlying ricin susceptibility. Cell. 2013 Feb 14; 152(4):909-22. PMID: 23394947; PMCID: PMC3652613.
    74. Muzzey D, Schwartz K, Weissman J, Sherlock G. Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure. Genome Biol. 2013; 14(9):R97. PMID: 24025428; PMCID: PMC4054093.
    75. Stern-Ginossar N, Weisburd B, Michalski A, Le VT, Hein MY, Huang SX, Ma M, Shen B, Qian SB, Hengel H, Mann M, Ingolia NT, Weissman J. Decoding human cytomegalovirus. Science. 2012 Nov 23; 338(6110):1088-93. PMID: 23180859; PMCID: PMC3817102.
    76. Brandman O, Stewart-Ornstein J, Wong D, Larson A, Williams CC, Li GW, Zhou S, King D, Shen PS, Weibezahn J, Dunn JG, Rouskin S, Inada T, Frost A, Weissman J. A ribosome-bound quality control complex triggers degradation of nascent peptides and signals translation stress. Cell. 2012 Nov 21; 151(5):1042-54. PMID: 23178123; PMCID: PMC3534965.
    77. Ingolia NT, Brar GA, Rouskin S, McGeachy AM, Weissman J. The ribosome profiling strategy for monitoring translation in vivo by deep sequencing of ribosome-protected mRNA fragments. Nat Protoc. 2012 Aug; 7(8):1534-50. PMID: 22836135; PMCID: PMC3535016.
    78. Carvunis AR, Rolland T, Wapinski I, Calderwood MA, Yildirim MA, Simonis N, Charloteaux B, Hidalgo CA, Barbette J, Santhanam B, Brar GA, Weissman J, Regev A, Thierry-Mieg N, Cusick ME, Vidal M. Proto-genes and de novo gene birth. Nature. 2012 Jul 19; 487(7407):370-4. PMID: 22722833; PMCID: PMC3401362.
    79. Frost A, Elgort MG, Brandman O, Ives C, Collins SR, Miller-Vedam L, Weibezahn J, Hein MY, Poser I, Mann M, Hyman AA, Weissman J. Functional repurposing revealed by comparing S. pombe and S. cerevisiae genetic interactions. Cell. 2012 Jun 8; 149(6):1339-52. PMID: 22682253; PMCID: PMC3613983.
    80. Radford SE, Weissman J. Special issue: the molecular and cellular mechanisms of amyloidosis. J Mol Biol. 2012 Aug 10; 421(2-3):139-41. PMID: 22664198.
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    81. Churchman LS, Weissman J. Native elongating transcript sequencing (NET-seq). Curr Protoc Mol Biol. 2012 Apr; Chapter 4:Unit 4.14.1-17. PMID: 22470065.
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    82. Li GW, Oh E, Weissman J. The anti-Shine-Dalgarno sequence drives translational pausing and codon choice in bacteria. Nature. 2012 Apr 26; 484(7395):538-41. PMID: 22456704; PMCID: PMC3338875.
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    184. Ayanian JZ, Cleary PD, Weissman J, Epstein AM. The effect of patients' preferences on racial differences in access to renal transplantation. N Engl J Med. 1999 Nov 25; 341(22):1661-9. PMID: 10572155.
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    185. Blumenthal D, Weissman J, Griner PF. Academic health centers on the front lines: survival strategies in highly competitive markets. Acad Med. 1999 Sep; 74(9):1038-49. PMID: 10498101.
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    186. Wang JD, Weissman J. Thinking outside the box: new insights into the mechanism of GroEL-mediated protein folding. Nat Struct Biol. 1999 Jul; 6(7):597-600. PMID: 10404205.
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    187. Weissman J, Ayanian JZ, Chasan-Taber S, Sherwood MJ, Roth C, Epstein AM. Hospital readmissions and quality of care. Med Care. 1999 May; 37(5):490-501. PMID: 10335751.
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    188. Weissman J, Saglam D, Campbell EG, Causino N, Blumenthal D. Market forces and unsponsored research in academic health centers. JAMA. 1999 Mar 24-31; 281(12):1093-8. PMID: 10188659.
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    189. Weissman J, Witzburg R, Linov P, Campbell EG. Termination from Medicaid: how does it affect access, continuity of care, and willingness to purchase insurance? J Health Care Poor Underserved. 1999 Feb; 10(1):122-37. PMID: 9989010.
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    190. Weissman J, Haas JS, Fowler FJ, Gatsonis C, Massagli MP, Seage GR, Cleary P. The stability of preferences for life-sustaining care among persons with AIDS in the Boston Health Study. Med Decis Making. 1999 Jan-Mar; 19(1):16-26. PMID: 9917016.
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    191. Wang JD, Michelitsch MD, Weissman J. GroEL-GroES-mediated protein folding requires an intact central cavity. Proc Natl Acad Sci U S A. 1998 Oct 13; 95(21):12163-8. PMID: 9770457; PMCID: PMC22802.
    192. DePace AH, Santoso A, Hillner P, Weissman J. A critical role for amino-terminal glutamine/asparagine repeats in the formation and propagation of a yeast prion. Cell. 1998 Jun 26; 93(7):1241-52. PMID: 9657156.
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    193. Wilson IB, Sullivan LM, Weissman J. Costs and outcomes of AIDS care: comparing a health maintenance organization with fee-for-service systems in the Boston Health Study. J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Apr 15; 17(5):424-32. PMID: 9562045.
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    194. Aridor M, Weissman J, Bannykh S, Nuoffer C, Balch WE. Cargo selection by the COPII budding machinery during export from the ER. J Cell Biol. 1998 Apr 6; 141(1):61-70. PMID: 9531548; PMCID: PMC2132735.
    195. Horwich AL, Burston SG, Rye HS, Weissman J, Fenton WA. Construction of single-ring and two-ring hybrid versions of bacterial chaperonin GroEL. Methods Enzymol. 1998; 290:141-6. PMID: 9534157.
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    196. Pollard MG, Travers KJ, Weissman J. Ero1p: a novel and ubiquitous protein with an essential role in oxidative protein folding in the endoplasmic reticulum. Mol Cell. 1998 Jan; 1(2):171-82. PMID: 9659914.
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    197. Horwich AL, Weissman J. Deadly conformations--protein misfolding in prion disease. Cell. 1997 May 16; 89(4):499-510. PMID: 9160742.
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    198. Weissman J, Cleary PD, Seage GR, Gatsonis C, Haas JS, Chasan-Taber S, Epstein AM. The influence of health-related quality of life and social characteristics on hospital use by patients with AIDS in the Boston Health Study. Med Care. 1996 Oct; 34(10):1037-56. PMID: 8843929.
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    199. Weissman J. Uncompensated hospital care. Will it be there if we need it? JAMA. 1996 Sep 11; 276(10):823-8. PMID: 8769594.
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    200. Burston SG, Weissman J, Farr GW, Fenton WA, Horwich AL. Release of both native and non-native proteins from a cis-only GroEL ternary complex. Nature. 1996 Sep 5; 383(6595):96-9. PMID: 8779722.
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    201. Weissman J, Levin K, Chasan-Taber S, Massagli MP, Seage GR, Scampini L. The validity of self-reported health-care utilization by AIDS patients. AIDS. 1996 Jun; 10(7):775-83. PMID: 8805870.
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    202. Fenton WA, Weissman J, Horwich AL. Putting a lid on protein folding: structure and function of the co-chaperonin, GroES. Chem Biol. 1996 Mar; 3(3):157-61. PMID: 8807841.
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    203. Weissman J, Rye HS, Fenton WA, Beechem JM, Horwich AL. Characterization of the active intermediate of a GroEL-GroES-mediated protein folding reaction. Cell. 1996 Feb 9; 84(3):481-90. PMID: 8608602.
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    204. Weissman J, Kim PS. A kinetic explanation for the rearrangement pathway of BPTI folding. Nat Struct Biol. 1995 Dec; 2(12):1123-30. PMID: 8846225.
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    205. Weissman J, Hohl CM, Kovalenko O, Kashi Y, Chen S, Braig K, Saibil HR, Fenton WA, Horwich AL. Mechanism of GroEL action: productive release of polypeptide from a sequestered position under GroES. Cell. 1995 Nov 17; 83(4):577-87. PMID: 7585961.
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    206. Yu MH, Weissman J, Kim PS. Contribution of individual side-chains to the stability of BPTI examined by alanine-scanning mutagenesis. J Mol Biol. 1995 Jun 2; 249(2):388-97. PMID: 7540212.
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    207. Weissman J. All roads lead to Rome? The multiple pathways of protein folding. Chem Biol. 1995 May; 2(5):255-60. PMID: 9383427.
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    208. Weissman J, Sigler PB, Horwich AL. From the cradle to the grave: ring complexes in the life of a protein. Science. 1995 Apr 28; 268(5210):523-4. PMID: 7725096.
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    209. Horwich AL, Weissman J, Fenton WA. Kinesis of polypeptide during GroEL-mediated folding. Cold Spring Harb Symp Quant Biol. 1995; 60:435-40. PMID: 8824417.
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    210. Epstein AM, Seage G, Weissman J, Cleary PD, Fowler FJ, Gatsonis C, Massagli MP, Stone VE, Coltin K, Craven DE. Costs of medical care and out-of-pocket expenditures for persons with AIDS in the Boston Health Study. Inquiry. 1995; 32(2):211-21. PMID: 7601519.
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    211. Weissman J, Kashi Y, Fenton WA, Horwich AL. GroEL-mediated protein folding proceeds by multiple rounds of binding and release of nonnative forms. Cell. 1994 Aug 26; 78(4):693-702. PMID: 7915201.
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    212. Craig EA, Weissman J, Horwich AL. Heat shock proteins and molecular chaperones: mediators of protein conformation and turnover in the cell. Cell. 1994 Aug 12; 78(3):365-72. PMID: 7914834.
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    213. Ettner SL, Weissman J. Utilization of formal and informal home care by AIDS patients in Boston: a comparison of intravenous drug users and homosexual males. Med Care. 1994 May; 32(5):459-70. PMID: 8182974.
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    214. Mort EA, Weissman J, Epstein AM. Physician discretion and racial variation in the use of surgical procedures. Arch Intern Med. 1994 Apr 11; 154(7):761-7. PMID: 8147680.
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    215. Weissman J, Stern RS, Epstein AM. The impact of patient socioeconomic status and other social factors on readmission: a prospective study in four Massachusetts hospitals. Inquiry. 1994; 31(2):163-72. PMID: 8021022.
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    216. Weissman J, Kim PS. Efficient catalysis of disulphide bond rearrangements by protein disulphide isomerase. Nature. 1993 Sep 9; 365(6442):185-8. PMID: 7690463.
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    217. Cleary PD, Fowler FJ, Weissman J, Massagli MP, Wilson I, Seage GR, Gatsonis C, Epstein A. Health-related quality of life in persons with acquired immune deficiency syndrome. Med Care. 1993 Jul; 31(7):569-80. PMID: 8326772.
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    218. Weissman J, Kim PS. The pro region of BPTI facilitates folding. Cell. 1992 Nov 27; 71(5):841-51. PMID: 1384990.
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    219. Weissman J, Gatsonis C, Epstein AM. Rates of avoidable hospitalization by insurance status in Massachusetts and Maryland. JAMA. 1992 Nov 4; 268(17):2388-94. PMID: 1404795.
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    220. Weissman J, Kim PS. Kinetic role of nonnative species in the folding of bovine pancreatic trypsin inhibitor. Proc Natl Acad Sci U S A. 1992 Oct 15; 89(20):9900-4. PMID: 1384063; PMCID: PMC50241.
    221. Stern RS, Weissman J, Epstein AM. The emergency department as a pathway to admission for poor and high-cost patients. JAMA. 1991 Oct 23-30; 266(16):2238-43. PMID: 1920722.
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    222. Weissman J, Kim PS. Reexamination of the folding of BPTI: predominance of native intermediates. Science. 1991 Sep 20; 253(5026):1386-93. PMID: 1716783.
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    223. Moore MR, Blatter DD, Weissman J, Tyler HR. Acute aortic thrombosis causing sudden paraplegia in a patient with known thoraco-lumbar spinal metastasis: the diagnostic usefulness of magnetic resonance imaging. Neurosurgery. 1989 Jul; 25(1):105-9. PMID: 2755568.
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    224. Weissman J, Epstein AM. Case mix and resource utilization by uninsured hospital patients in the Boston metropolitan area. JAMA. 1989 Jun 23-30; 261(24):3572-6. PMID: 2498539.
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    225. McAuliffe WE, Santangelo S, Magnuson E, Sobol A, Rohman M, Weissman J. Risk factors of drug impairment in random samples of physicians and medical students. Int J Addict. 1987 Sep; 22(9):825-41. PMID: 3679638.
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