Jonathan Weissman, PhD

InstitutionUniversity of California San Francisco
DepartmentCellular Molecular Pharmacology
Address1700 4th St
San Francisco CA 94158
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    Other Positions
    TitleProfessor, School of Medicine

    Collapse Research 
    Collapse Research Activities and Funding
    The Cancer Target Discovery and Development Network at UCSF
    NIH/NCI U01CA217882Aug 10, 2017 - Jul 31, 2022
    Role: Co-Principal Investigator
    Harnessing CRISPR for Targeted and Inducible Epigenomic Reprogramming
    NIH/NIDA R01DA036858Sep 30, 2013 - May 31, 2018
    Role: Principal Investigator
    Structural Basis of Protein Homeostasis
    NIH/NIGMS U01GM098254Sep 30, 2012 - Jul 31, 2015
    Role: Co-Principal Investigator
    Human Gene Knockdowns that May Extend Lifespan
    NIH/NIA R01AG041826May 1, 2012 - Apr 30, 2017
    Role: Principal Investigator
    Bay Area Cancer Target Discovery and Development Network
    NIH/NCI U01CA168370May 1, 2012 - Apr 30, 2017
    Role: Co-Principal Investigator
    NIH/NIGMS R01GM055595May 1, 1997 - Apr 30, 2002
    Role: Principal Investigator
    Molecular Pathogenesis of Age-Dependent CNS Regeneration
    NIH/NIA P01AG010770Apr 1, 1993 - Mar 31, 2016
    Role: Co-Investigator
    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Global Health
    Collapse Websites
    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Yu Z, Surface LE, Park CY, Horlbeck MA, Wyant GA, Abu-Remaileh M, Peterson TR, Sabatini DM, Weissman J, O'Shea EK. Identification of a transporter complex responsible for the cytosolic entry of nitrogen-containing-bisphosphonates. Elife. 2018 May 10; 7. PMID: 29745899.
      View in: PubMed
    2. Cho SW, Xu J, Sun R, Mumbach MR, Carter AC, Chen YG, Yost KE, Kim J, He J, Nevins SA, Chin SF, Caldas C, Liu SJ, Horlbeck MA, Lim DA, Weissman J, Curtis C, Chang HY. Promoter of lncRNA Gene PVT1 Is a Tumor-Suppressor DNA Boundary Element. Cell. 2018 Apr 25. PMID: 29731168.
      View in: PubMed
    3. Zhang Y, Burkhardt DH, Rouskin S, Li GW, Weissman J, Gross CA. A Stress Response that Monitors and Regulates mRNA Structure Is Central to Cold Shock Adaptation. Mol Cell. 2018 Apr 19; 70(2):274-286.e7. PMID: 29628307.
      View in: PubMed
    4. Jost M, Weissman J. CRISPR Approaches to Small Molecule Target Identification. ACS Chem Biol. 2018 Feb 16; 13(2):366-375. PMID: 29261286.
      View in: PubMed
    5. Martinko AJ, Truillet C, Julien O, Diaz JE, Horlbeck MA, Whiteley G, Blonder J, Weissman J, Bandyopadhyay S, Evans MJ, Wells JA. Targeting RAS-driven human cancer cells with antibodies to upregulated and essential cell-surface proteins. Elife. 2018 Jan 23; 7. PMID: 29359686.
      View in: PubMed
    6. Costa EA, Subramanian K, Nunnari J, Weissman J. Defining the physiological role of SRP in protein-targeting efficiency and specificity. Science. 2018 02 09; 359(6376):689-692. PMID: 29348368.
      View in: PubMed
    7. Friedman JR, Kannan M, Toulmay A, Jan CH, Weissman J, Prinz WA, Nunnari J. Lipid Homeostasis Is Maintained by Dual Targeting of the Mitochondrial PE Biosynthesis Enzyme to the ER. Dev Cell. 2018 Jan 22; 44(2):261-270.e6. PMID: 29290583.
      View in: PubMed
    8. Regev A, Teichmann SA, Lander ES, Amit I, Benoist C, Birney E, Bodenmiller B, Campbell P, Carninci P, Clatworthy M, Clevers H, Deplancke B, Dunham I, Eberwine J, Eils R, Enard W, Farmer A, Fugger L, Göttgens B, Hacohen N, Haniffa M, Hemberg M, Kim S, Klenerman P, Kriegstein A, Lein E, Linnarsson S, Lundberg E, Lundeberg J, Majumder P, Marioni JC, Merad M, Mhlanga M, Nawijn M, Netea M, Nolan G, Pe'er D, Phillipakis A, Ponting CP, Quake S, Reik W, Rozenblatt-Rosen O, Sanes J, Satija R, Schumacher TN, Shalek A, Shapiro E, Sharma P, Shin JW, Stegle O, Stratton M, Stubbington MJT, Theis FJ, Uhlen M, van Oudenaarden A, Wagner A, Watt F, Weissman J, Wold B, Xavier R, Yosef N. The Human Cell Atlas. Elife. 2017 12 05; 6. PMID: 29206104.
      View in: PubMed
    9. Wangensteen KJ, Wang YJ, Dou Z, Wang AW, Mosleh-Shirazi E, Horlbeck MA, Gilbert LA, Weissman J, Berger SL, Kaestner KH. Combinatorial genetics in liver repopulation and carcinogenesis with a novel in vivo CRISPR activation platform. Hepatology. 2017 Nov 01. PMID: 29091290.
      View in: PubMed
    10. Tak YE, Kleinstiver BP, Nuñez JK, Hsu JY, Horng JE, Gong J, Weissman J, Joung JK. Inducible and multiplex gene regulation using CRISPR-Cpf1-based transcription factors. Nat Methods. 2017 Dec; 14(12):1163-1166. PMID: 29083402.
      View in: PubMed
    11. Jost M, Chen Y, Gilbert LA, Horlbeck MA, Krenning L, Menchon G, Rai A, Cho MY, Stern JJ, Prota AE, Kampmann M, Akhmanova A, Steinmetz MO, Tanenbaum ME, Weissman J. Combined CRISPRi/a-Based Chemical Genetic Screens Reveal that Rigosertib Is a Microtubule-Destabilizing Agent. Mol Cell. 2017 Oct 05; 68(1):210-223.e6. PMID: 28985505.
      View in: PubMed
    12. Kostova KK, Hickey KL, Osuna BA, Hussmann JA, Frost A, Weinberg DE, Weissman J. CAT-tailing as a fail-safe mechanism for efficient degradation of stalled nascent polypeptides. Science. 2017 07 28; 357(6349):414-417. PMID: 28751611.
      View in: PubMed
    13. Kruth KA, Fang M, Shelton DN, Abu-Halawa O, Mahling R, Yang H, Weissman J, Loh ML, Müschen M, Tasian SK, Bassik MC, Kampmann M, Pufall MA. Suppression of B-cell development genes is key to glucocorticoid efficacy in treatment of acute lymphoblastic leukemia. Blood. 2017 06 01; 129(22):3000-3008. PMID: 28424165.
      View in: PubMed
    14. Burkhardt DH, Rouskin S, Zhang Y, Li GW, Weissman J, Gross CA. Operon mRNAs are organized into ORF-centric structures that predict translation efficiency. Elife. 2017 Jan 31; 6. PMID: 28139975.
      View in: PubMed
    15. Sendoel A, Dunn JG, Rodriguez EH, Naik S, Gomez NC, Hurwitz B, Levorse J, Dill BD, Schramek D, Molina H, Weissman J, Fuchs E. Translation from unconventional 5' start sites drives tumour initiation. Nature. 2017 01 26; 541(7638):494-499. PMID: 28077873.
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    16. Dixit A, Parnas O, Li B, Chen J, Fulco CP, Jerby-Arnon L, Marjanovic ND, Dionne D, Burks T, Raychowdhury R, Adamson B, Norman TM, Lander ES, Weissman J, Friedman N, Regev A. Perturb-Seq: Dissecting Molecular Circuits with Scalable Single-Cell RNA Profiling of Pooled Genetic Screens. Cell. 2016 Dec 15; 167(7):1853-1866.e17. PMID: 27984732.
      View in: PubMed
    17. Adamson B, Norman TM, Jost M, Cho MY, Nuñez JK, Chen Y, Villalta JE, Gilbert LA, Horlbeck MA, Hein MY, Pak RA, Gray AN, Gross CA, Dixit A, Parnas O, Regev A, Weissman J. A Multiplexed Single-Cell CRISPR Screening Platform Enables Systematic Dissection of the Unfolded Protein Response. Cell. 2016 Dec 15; 167(7):1867-1882.e21. PMID: 27984733.
      View in: PubMed
    18. Liu SJ, Horlbeck MA, Cho SW, Birk HS, Malatesta M, He D, Attenello FJ, Villalta JE, Cho MY, Chen Y, Mandegar MA, Olvera MP, Gilbert LA, Conklin BR, Chang HY, Weissman J, Lim DA. CRISPRi-based genome-scale identification of functional long noncoding RNA loci in human cells. Science. 2017 01 06; 355(6320). PMID: 27980086.
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    19. Besnard E, Hakre S, Kampmann M, Lim HW, Hosmane NN, Martin A, Bassik MC, Verschueren E, Battivelli E, Chan J, Svensson JP, Gramatica A, Conrad RJ, Ott M, Greene WC, Krogan NJ, Siliciano RF, Weissman J, Verdin E. The mTOR Complex Controls HIV Latency. Cell Host Microbe. 2016 Dec 14; 20(6):785-797. PMID: 27978436.
      View in: PubMed
    20. Aviram N, Ast T, Costa EA, Arakel EC, Chuartzman SG, Jan CH, Haßdenteufel S, Dudek J, Jung M, Schorr S, Zimmermann R, Schwappach B, Weissman J, Schuldiner M. The SND proteins constitute an alternative targeting route to the endoplasmic reticulum. Nature. 2016 11 30; 540(7631):134-138. PMID: 27905431.
      View in: PubMed
    21. Dunn JG, Weissman J. Plastid: nucleotide-resolution analysis of next-generation sequencing and genomics data. BMC Genomics. 2016 11 22; 17(1):958. PMID: 27875984.
      View in: PubMed
    22. Stewart-Ornstein J, Chen S, Bhatnagar R, Weissman J, El-Samad H. Model-guided optogenetic study of PKA signaling in budding yeast. Mol Biol Cell. 2017 Jan 01; 28(1):221-227. PMID: 28035051.
      View in: PubMed
    23. Zubradt M, Gupta P, Persad S, Lambowitz AM, Weissman J, Rouskin S. DMS-MaPseq for genome-wide or targeted RNA structure probing in vivo. Nat Methods. 2017 01; 14(1):75-82. PMID: 27819661.
      View in: PubMed
    24. Schrader JM, Li GW, Childers WS, Perez AM, Weissman J, Shapiro L, McAdams HH. Dynamic translation regulation in Caulobacter cell cycle control. Proc Natl Acad Sci U S A. 2016 11 01; 113(44):E6859-E6867. PMID: 27791168.
      View in: PubMed
    25. Horlbeck MA, Gilbert LA, Villalta JE, Adamson B, Pak RA, Chen Y, Fields AP, Park CY, Corn JE, Kampmann M, Weissman J. Compact and highly active next-generation libraries for CRISPR-mediated gene repression and activation. Elife. 2016 09 23; 5. PMID: 27661255.
      View in: PubMed
    26. Sabnis AJ, Guerriero CJ, Olivas V, Sayana A, Shue J, Flanagan J, Asthana S, Paton AW, Paton JC, Gestwicki JE, Walter P, Weissman J, Wipf P, Brodsky JL, Bivona TG. Combined chemical-genetic approach identifies cytosolic HSP70 dependence in rhabdomyosarcoma. Proc Natl Acad Sci U S A. 2016 08 09; 113(32):9015-20. PMID: 27450084; PMCID: PMC4987817 [Available on 02/09/17].
    27. Nguyen DP, Miyaoka Y, Gilbert LA, Mayerl SJ, Lee BH, Weissman J, Conklin BR, Wells JA. Ligand-binding domains of nuclear receptors facilitate tight control of split CRISPR activity. Nat Commun. 2016 Jul 01; 7:12009. PMID: 27363581; PMCID: PMC4932181.
    28. Liu YC, Fujimori DG, Weissman J. Htm1p-Pdi1p is a folding-sensitive mannosidase that marks N-glycoproteins for ER-associated protein degradation. Proc Natl Acad Sci U S A. 2016 07 12; 113(28):E4015-24. PMID: 27357682; PMCID: PMC4948361 [Available on 01/12/17].
    29. Braun CJ, Bruno PM, Horlbeck MA, Gilbert LA, Weissman J, Hemann MT. Versatile in vivo regulation of tumor phenotypes by dCas9-mediated transcriptional perturbation. Proc Natl Acad Sci U S A. 2016 07 05; 113(27):E3892-900. PMID: 27325776.
      View in: PubMed
    30. Leonetti MD, Sekine S, Kamiyama D, Weissman J, Huang B. A scalable strategy for high-throughput GFP tagging of endogenous human proteins. Proc Natl Acad Sci U S A. 2016 06 21; 113(25):E3501-8. PMID: 27274053; PMCID: PMC4922190 [Available on 12/21/16].
    31. Peters JM, Colavin A, Shi H, Czarny TL, Larson MH, Wong S, Hawkins JS, Lu CHS, Koo BM, Marta E, Shiver AL, Whitehead EH, Weissman J, Brown ED, Qi LS, Huang KC, Gross CA. A Comprehensive, CRISPR-based Functional Analysis of Essential Genes in Bacteria. Cell. 2016 Jun 02; 165(6):1493-1506. PMID: 27238023; PMCID: PMC4894308 [Available on 06/02/17].
    32. Liu SJ, Nowakowski TJ, Pollen AA, Lui JH, Horlbeck MA, Attenello FJ, He D, Weissman J, Kriegstein AR, Diaz AA, Lim DA. Single-cell analysis of long non-coding RNAs in the developing human neocortex. Genome Biol. 2016 Apr 14; 17:67. PMID: 27081004; PMCID: PMC4831157.
    33. Kamiyama D, Sekine S, Barsi-Rhyne B, Hu J, Chen B, Gilbert LA, Ishikawa H, Leonetti MD, Marshall WF, Weissman J, Huang B. Versatile protein tagging in cells with split fluorescent protein. Nat Commun. 2016 Mar 18; 7:11046. PMID: 26988139; PMCID: PMC4802074.
    34. Horlbeck MA, Witkowsky LB, Guglielmi B, Replogle JM, Gilbert LA, Villalta JE, Torigoe SE, Tjian R, Weissman J. Nucleosomes impede Cas9 access to DNA in vivo and in vitro. Elife. 2016 03 17; 5. PMID: 26987018; PMCID: PMC4861601.
    35. Mandegar MA, Huebsch N, Frolov EB, Shin E, Truong A, Olvera MP, Chan AH, Miyaoka Y, Holmes K, Spencer CI, Judge LM, Gordon DE, Eskildsen TV, Villalta JE, Horlbeck MA, Gilbert LA, Krogan NJ, Sheikh SP, Weissman J, Qi LS, So PL, Conklin BR. CRISPR Interference Efficiently Induces Specific and Reversible Gene Silencing in Human iPSCs. Cell Stem Cell. 2016 Apr 07; 18(4):541-53. PMID: 26971820; PMCID: PMC4830697 [Available on 04/07/17].
    36. Fields AP, Rodriguez EH, Jovanovic M, Stern-Ginossar N, Haas BJ, Mertins P, Raychowdhury R, Hacohen N, Carr SA, Ingolia NT, Regev A, Weissman J. A Regression-Based Analysis of Ribosome-Profiling Data Reveals a Conserved Complexity to Mammalian Translation. Mol Cell. 2015 Dec 03; 60(5):816-827. PMID: 26638175; PMCID: PMC4720255 [Available on 12/03/16].
    37. Suzuki G, Weissman J, Tanaka M. [KIL-d] Protein Element Confers Antiviral Activity via Catastrophic Viral Mutagenesis. Mol Cell. 2015 Nov 19; 60(4):651-60. PMID: 26590718.
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    38. Anderson DJ, Le Moigne R, Djakovic S, Kumar B, Rice J, Wong S, Wang J, Yao B, Valle E, Kiss von Soly S, Madriaga A, Soriano F, Menon MK, Wu ZY, Kampmann M, Chen Y, Weissman J, Aftab BT, Yakes FM, Shawver L, Zhou HJ, Wustrow D, Rolfe M. Targeting the AAA ATPase p97 as an Approach to Treat Cancer through Disruption of Protein Homeostasis. Cancer Cell. 2015 Nov 09; 28(5):653-665. PMID: 26555175; PMCID: PMC4941640.
    39. Brar GA, Weissman J. Ribosome profiling reveals the what, when, where and how of protein synthesis. Nat Rev Mol Cell Biol. 2015 Nov; 16(11):651-64. PMID: 26465719.
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    40. Acosta-Alvear D, Cho MY, Wild T, Buchholz TJ, Lerner AG, Simakova O, Hahn J, Korde N, Landgren O, Maric I, Choudhary C, Walter P, Weissman J, Kampmann M. Paradoxical resistance of multiple myeloma to proteasome inhibitors by decreased levels of 19S proteasomal subunits. Elife. 2015 Sep 01; 4:e08153. PMID: 26327694; PMCID: PMC4602331.
    41. Tanenbaum ME, Stern-Ginossar N, Weissman J, Vale RD. Regulation of mRNA translation during mitosis. Elife. 2015 Aug 25; 4. PMID: 26305499; PMCID: PMC4548207.
    42. Kampmann M, Horlbeck MA, Chen Y, Tsai JC, Bassik MC, Gilbert LA, Villalta JE, Kwon SC, Chang H, Kim VN, Weissman J. Next-generation libraries for robust RNA interference-based genome-wide screens. Proc Natl Acad Sci U S A. 2015 Jun 30; 112(26):E3384-91. PMID: 26080438; PMCID: PMC4491794.
    43. Jan CH, Williams CC, Weissman J. LOCAL TRANSLATION. Response to Comment on "Principles of ER cotranslational translocation revealed by proximity-specific ribosome profiling". Science. 2015 Jun 12; 348(6240):1217. PMID: 26068842.
      View in: PubMed
    44. Sidrauski C, Tsai JC, Kampmann M, Hearn BR, Vedantham P, Jaishankar P, Sokabe M, Mendez AS, Newton BW, Tang EL, Verschueren E, Johnson JR, Krogan NJ, Fraser CS, Weissman J, Renslo AR, Walter P. Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response. Elife. 2015 Apr 15; 4:e07314. PMID: 25875391; PMCID: PMC4426669.
    45. Kampmann M, Bassik MC, Weissman J. Corrigendum: functional genomics platform for pooled screening and generation of mammalian genetic interaction maps. Nat Protoc. 2015 Apr; 10(4):643. PMID: 25811902.
      View in: PubMed
    46. Baltimore D, Berg P, Botchan M, Carroll D, Charo RA, Church G, Corn JE, Daley GQ, Doudna JA, Fenner M, Greely HT, Jinek M, Martin GS, Penhoet E, Puck J, Sternberg SH, Weissman J, Yamamoto KR. Biotechnology. A prudent path forward for genomic engineering and germline gene modification. Science. 2015 Apr 03; 348(6230):36-8. PMID: 25791083; PMCID: PMC4394183.
    47. Jovanovic M, Rooney MS, Mertins P, Przybylski D, Chevrier N, Satija R, Rodriguez EH, Fields AP, Schwartz S, Raychowdhury R, Mumbach MR, Eisenhaure T, Rabani M, Gennert D, Lu D, Delorey T, Weissman J, Carr SA, Hacohen N, Regev A. Immunogenetics. Dynamic profiling of the protein life cycle in response to pathogens. Science. 2015 Mar 06; 347(6226):1259038. PMID: 25745177; PMCID: PMC4506746.
    48. Li X, Colvin T, Rauch JN, Acosta-Alvear D, Kampmann M, Dunyak B, Hann B, Aftab BT, Murnane M, Cho M, Walter P, Weissman J, Sherman MY, Gestwicki JE. Validation of the Hsp70-Bag3 protein-protein interaction as a potential therapeutic target in cancer. Mol Cancer Ther. 2015 Mar; 14(3):642-8. PMID: 25564440; PMCID: PMC4456214.
    49. Shen PS, Park J, Qin Y, Li X, Parsawar K, Larson MH, Cox J, Cheng Y, Lambowitz AM, Weissman J, Brandman O, Frost A. Protein synthesis. Rqc2p and 60S ribosomal subunits mediate mRNA-independent elongation of nascent chains. Science. 2015 Jan 02; 347(6217):75-8. PMID: 25554787; PMCID: PMC4451101.
    50. Pop C, Rouskin S, Ingolia NT, Han L, Phizicky EM, Weissman J, Koller D. Causal signals between codon bias, mRNA structure, and the efficiency of translation and elongation. Mol Syst Biol. 2014 Dec 23; 10:770. PMID: 25538139; PMCID: PMC4300493.
    51. Zalatan JG, Lee ME, Almeida R, Gilbert LA, Whitehead EH, La Russa M, Tsai JC, Weissman J, Dueber JE, Qi LS, Lim WA. Engineering complex synthetic transcriptional programs with CRISPR RNA scaffolds. Cell. 2015 Jan 15; 160(1-2):339-50. PMID: 25533786; PMCID: PMC4297522.
    52. Williams CC, Jan CH, Weissman J. Targeting and plasticity of mitochondrial proteins revealed by proximity-specific ribosome profiling. Science. 2014 Nov 07; 346(6210):748-51. PMID: 25378625; PMCID: PMC4263316.
    53. Jan CH, Williams CC, Weissman J. Principles of ER cotranslational translocation revealed by proximity-specific ribosome profiling. Science. 2014 Nov 07; 346(6210):1257521. PMID: 25378630; PMCID: PMC4285348.
    54. Kannan K, Kanabar P, Schryer D, Florin T, Oh E, Bahroos N, Tenson T, Weissman J, Mankin AS. The general mode of translation inhibition by macrolide antibiotics. Proc Natl Acad Sci U S A. 2014 Nov 11; 111(45):15958-63. PMID: 25349425; PMCID: PMC4234590.
    55. Albert FW, Muzzey D, Weissman J, Kruglyak L. Genetic influences on translation in yeast. PLoS Genet. 2014 Oct; 10(10):e1004692. PMID: 25340754; PMCID: PMC4207643.
    56. Tanenbaum ME, Gilbert LA, Qi LS, Weissman J, Vale RD. A protein-tagging system for signal amplification in gene expression and fluorescence imaging. Cell. 2014 Oct 23; 159(3):635-46. PMID: 25307933; PMCID: PMC4252608.
    57. Gilbert LA, Horlbeck MA, Adamson B, Villalta JE, Chen Y, Whitehead EH, Guimaraes C, Panning B, Ploegh HL, Bassik MC, Qi LS, Kampmann M, Weissman J. Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation. Cell. 2014 Oct 23; 159(3):647-61. PMID: 25307932; PMCID: PMC4253859.
    58. Julien O, Kampmann M, Bassik MC, Zorn JA, Venditto VJ, Shimbo K, Agard NJ, Shimada K, Rheingold AL, Stockwell BR, Weissman J, Wells JA. Unraveling the mechanism of cell death induced by chemical fibrils. Nat Chem Biol. 2014 Nov; 10(11):969-76. PMID: 25262416; PMCID: PMC4201873.
    59. Ingolia NT, Brar GA, Stern-Ginossar N, Harris MS, Talhouarne GJ, Jackson SE, Wills MR, Weissman J. Ribosome profiling reveals pervasive translation outside of annotated protein-coding genes. Cell Rep. 2014 Sep 11; 8(5):1365-79. PMID: 25159147; PMCID: PMC4216110.
    60. Smith MH, Rodriguez EH, Weissman J. Misfolded proteins induce aggregation of the lectin Yos9. J Biol Chem. 2014 Sep 12; 289(37):25670-7. PMID: 25086047; PMCID: PMC4162170.
    61. Kampmann M, Bassik MC, Weissman J. Functional genomics platform for pooled screening and generation of mammalian genetic interaction maps. Nat Protoc. 2014 Aug; 9(8):1825-47. PMID: 24992097; PMCID: PMC4144868.
    62. van de Weijer ML, Bassik MC, Luteijn RD, Voorburg CM, Lohuis MA, Kremmer E, Hoeben RC, LeProust EM, Chen S, Hoelen H, Ressing ME, Patena W, Weissman J, McManus MT, Wiertz EJ, Lebbink RJ. A high-coverage shRNA screen identifies TMEM129 as an E3 ligase involved in ER-associated protein degradation. Nat Commun. 2014 May 08; 5:3832. PMID: 24807418; PMCID: PMC4024746.
    63. Larson MH, Mooney RA, Peters JM, Windgassen T, Nayak D, Gross CA, Block SM, Greenleaf WJ, Landick R, Weissman J. A pause sequence enriched at translation start sites drives transcription dynamics in vivo. Science. 2014 May 30; 344(6187):1042-7. PMID: 24789973; PMCID: PMC4108260.
    64. Li GW, Burkhardt D, Gross C, Weissman J. Quantifying absolute protein synthesis rates reveals principles underlying allocation of cellular resources. Cell. 2014 Apr 24; 157(3):624-35. PMID: 24766808; PMCID: PMC4006352.
    65. Muzzey D, Sherlock G, Weissman J. Extensive and coordinated control of allele-specific expression by both transcription and translation in Candida albicans. Genome Res. 2014 Jun; 24(6):963-73. PMID: 24732588; PMCID: PMC4032860.
    66. Pfanner N, van der Laan M, Amati P, Capaldi RA, Caudy AA, Chacinska A, Darshi M, Deckers M, Hoppins S, Icho T, Jakobs S, Ji J, Kozjak-Pavlovic V, Meisinger C, Odgren PR, Park SK, Rehling P, Reichert AS, Sheikh MS, Taylor SS, Tsuchida N, van der Bliek AM, van der Klei IJ, Weissman J, Westermann B, Zha J, Neupert W, Nunnari J. Uniform nomenclature for the mitochondrial contact site and cristae organizing system. J Cell Biol. 2014 Mar 31; 204(7):1083-6. PMID: 24687277; PMCID: PMC3971754.
    67. Wolff S, Weissman J, Dillin A. Differential scales of protein quality control. Cell. 2014 Mar 27; 157(1):52-64. PMID: 24679526.
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    68. Arias C, Weisburd B, Stern-Ginossar N, Mercier A, Madrid AS, Bellare P, Holdorf M, Weissman J, Ganem D. KSHV 2.0: a comprehensive annotation of the Kaposi's sarcoma-associated herpesvirus genome using next-generation sequencing reveals novel genomic and functional features. PLoS Pathog. 2014 Jan; 10(1):e1003847. PMID: 24453964; PMCID: PMC3894221.
    69. Chen B, Gilbert LA, Cimini BA, Schnitzbauer J, Zhang W, Li GW, Park J, Blackburn EH, Weissman J, Qi LS, Huang B. Dynamic imaging of genomic loci in living human cells by an optimized CRISPR/Cas system. Cell. 2013 Dec 19; 155(7):1479-91. PMID: 24360272; PMCID: PMC3918502.
    70. Rouskin S, Zubradt M, Washietl S, Kellis M, Weissman J. Genome-wide probing of RNA structure reveals active unfolding of mRNA structures in vivo. Nature. 2014 Jan 30; 505(7485):701-5. PMID: 24336214; PMCID: PMC3966492.
    71. Dunn JG, Foo CK, Belletier NG, Gavis ER, Weissman J. Ribosome profiling reveals pervasive and regulated stop codon readthrough in Drosophila melanogaster. Elife. 2013 Dec 03; 2:e01179. PMID: 24302569; PMCID: PMC3840789.
    72. Stewart-Ornstein J, Nelson C, DeRisi J, Weissman J, El-Samad H. Msn2 coordinates a stoichiometric gene expression program. Curr Biol. 2013 Dec 02; 23(23):2336-45. PMID: 24210615; PMCID: PMC4072881.
    73. Matheny CJ, Wei MC, Bassik MC, Donnelly AJ, Kampmann M, Iwasaki M, Piloto O, Solow-Cordero DE, Bouley DM, Rau R, Brown P, McManus MT, Weissman J, Cleary ML. Next-generation NAMPT inhibitors identified by sequential high-throughput phenotypic chemical and functional genomic screens. Chem Biol. 2013 Nov 21; 20(11):1352-63. PMID: 24183972.
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    74. Wiita AP, Ziv E, Wiita PJ, Urisman A, Julien O, Burlingame AL, Weissman J, Wells JA. Global cellular response to chemotherapy-induced apoptosis. Elife. 2013 Oct 29; 2:e01236. PMID: 24171104; PMCID: PMC3808542.
    75. Becker AH, Oh E, Weissman J, Kramer G, Bukau B. Selective ribosome profiling as a tool for studying the interaction of chaperones and targeting factors with nascent polypeptide chains and ribosomes. Nat Protoc. 2013 Nov; 8(11):2212-39. PMID: 24136347; PMCID: PMC4001812.
    76. Larson MH, Gilbert LA, Wang X, Lim WA, Weissman J, Qi LS. CRISPR interference (CRISPRi) for sequence-specific control of gene expression. Nat Protoc. 2013 Nov; 8(11):2180-96. PMID: 24136345; PMCID: PMC3922765.
    77. Berchowitz LE, Gajadhar AS, van Werven FJ, De Rosa AA, Samoylova ML, Brar GA, Xu Y, Xiao C, Futcher B, Weissman J, White FM, Amon A. A developmentally regulated translational control pathway establishes the meiotic chromosome segregation pattern. Genes Dev. 2013 Oct 01; 27(19):2147-63. PMID: 24115771; PMCID: PMC3850098.
    78. Gilbert LA, Larson MH, Morsut L, Liu Z, Brar GA, Torres SE, Stern-Ginossar N, Brandman O, Whitehead EH, Doudna JA, Lim WA, Weissman J, Qi LS. CRISPR-mediated modular RNA-guided regulation of transcription in eukaryotes. Cell. 2013 Jul 18; 154(2):442-51. PMID: 23849981; PMCID: PMC3770145.
    79. Ingolia NT, Brar GA, Rouskin S, McGeachy AM, Weissman J. Genome-wide annotation and quantitation of translation by ribosome profiling. Curr Protoc Mol Biol. 2013 Jul; Chapter 4:Unit 4.18. PMID: 23821443; PMCID: PMC3775365.
    80. Guttman M, Russell P, Ingolia NT, Weissman J, Lander ES. Ribosome profiling provides evidence that large noncoding RNAs do not encode proteins. Cell. 2013 Jul 03; 154(1):240-51. PMID: 23810193; PMCID: PMC3756563.
    81. Kampmann M, Bassik MC, Weissman J. Integrated platform for genome-wide screening and construction of high-density genetic interaction maps in mammalian cells. Proc Natl Acad Sci U S A. 2013 Jun 18; 110(25):E2317-26. PMID: 23739767; PMCID: PMC3690882.
    82. O'Connor PB, Li GW, Weissman J, Atkins JF, Baranov PV. rRNA:mRNA pairing alters the length and the symmetry of mRNA-protected fragments in ribosome profiling experiments. Bioinformatics. 2013 Jun 15; 29(12):1488-91. PMID: 23603333; PMCID: PMC3673220.
    83. Thorburn RR, Gonzalez C, Brar GA, Christen S, Carlile TM, Ingolia NT, Sauer U, Weissman J, Amon A. Aneuploid yeast strains exhibit defects in cell growth and passage through START. Mol Biol Cell. 2013 May; 24(9):1274-89. PMID: 23468524; PMCID: PMC3639041.
    84. Schuldiner M, Weissman J. The contribution of systematic approaches to characterizing the proteins and functions of the endoplasmic reticulum. Cold Spring Harb Perspect Biol. 2013 Mar 01; 5(3):a013284. PMID: 23359093; PMCID: PMC3578357.
    85. Qi LS, Larson MH, Gilbert LA, Doudna JA, Weissman J, Arkin AP, Lim WA. Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression. Cell. 2013 Feb 28; 152(5):1173-83. PMID: 23452860; PMCID: PMC3664290.
    86. Bassik MC, Kampmann M, Lebbink RJ, Wang S, Hein MY, Poser I, Weibezahn J, Horlbeck MA, Chen S, Mann M, Hyman AA, Leproust EM, McManus MT, Weissman J. A systematic mammalian genetic interaction map reveals pathways underlying ricin susceptibility. Cell. 2013 Feb 14; 152(4):909-22. PMID: 23394947; PMCID: PMC3652613.
    87. Muzzey D, Schwartz K, Weissman J, Sherlock G. Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure. Genome Biol. 2013; 14(9):R97. PMID: 24025428; PMCID: PMC4054093.
    88. Stern-Ginossar N, Weisburd B, Michalski A, Le VT, Hein MY, Huang SX, Ma M, Shen B, Qian SB, Hengel H, Mann M, Ingolia NT, Weissman J. Decoding human cytomegalovirus. Science. 2012 Nov 23; 338(6110):1088-93. PMID: 23180859; PMCID: PMC3817102.
    89. Brandman O, Stewart-Ornstein J, Wong D, Larson A, Williams CC, Li GW, Zhou S, King D, Shen PS, Weibezahn J, Dunn JG, Rouskin S, Inada T, Frost A, Weissman J. A ribosome-bound quality control complex triggers degradation of nascent peptides and signals translation stress. Cell. 2012 Nov 21; 151(5):1042-54. PMID: 23178123; PMCID: PMC3534965.
    90. Ingolia NT, Brar GA, Rouskin S, McGeachy AM, Weissman J. The ribosome profiling strategy for monitoring translation in vivo by deep sequencing of ribosome-protected mRNA fragments. Nat Protoc. 2012 Jul 26; 7(8):1534-50. PMID: 22836135; PMCID: PMC3535016.
    91. Carvunis AR, Rolland T, Wapinski I, Calderwood MA, Yildirim MA, Simonis N, Charloteaux B, Hidalgo CA, Barbette J, Santhanam B, Brar GA, Weissman J, Regev A, Thierry-Mieg N, Cusick ME, Vidal M. Proto-genes and de novo gene birth. Nature. 2012 Jul 19; 487(7407):370-4. PMID: 22722833; PMCID: PMC3401362.
    92. Frost A, Elgort MG, Brandman O, Ives C, Collins SR, Miller-Vedam L, Weibezahn J, Hein MY, Poser I, Mann M, Hyman AA, Weissman J. Functional repurposing revealed by comparing S. pombe and S. cerevisiae genetic interactions. Cell. 2012 Jun 08; 149(6):1339-52. PMID: 22682253; PMCID: PMC3613983.
    93. Radford SE, Weissman J. Special issue: the molecular and cellular mechanisms of amyloidosis. J Mol Biol. 2012 Aug 10; 421(2-3):139-41. PMID: 22664198.
      View in: PubMed
    94. Churchman LS, Weissman J. Native elongating transcript sequencing (NET-seq). Curr Protoc Mol Biol. 2012 Apr; Chapter 4:Unit 4.14.1-17. PMID: 22470065.
      View in: PubMed
    95. Li GW, Oh E, Weissman J. The anti-Shine-Dalgarno sequence drives translational pausing and codon choice in bacteria. Nature. 2012 Mar 28; 484(7395):538-41. PMID: 22456704; PMCID: PMC3338875.
    96. Stewart-Ornstein J, Weissman J, El-Samad H. Cellular noise regulons underlie fluctuations in Saccharomyces cerevisiae. Mol Cell. 2012 Feb 24; 45(4):483-93. PMID: 22365828; PMCID: PMC3327736.
    97. Hsieh AC, Liu Y, Edlind MP, Ingolia NT, Janes MR, Sher A, Shi EY, Stumpf CR, Christensen C, Bonham MJ, Wang S, Ren P, Martin M, Jessen K, Feldman ME, Weissman J, Shokat KM, Rommel C, Ruggero D. The translational landscape of mTOR signalling steers cancer initiation and metastasis. Nature. 2012 Feb 22; 485(7396):55-61. PMID: 22367541; PMCID: PMC3663483.
    98. Brar GA, Yassour M, Friedman N, Regev A, Ingolia NT, Weissman J. High-resolution view of the yeast meiotic program revealed by ribosome profiling. Science. 2012 Feb 03; 335(6068):552-7. PMID: 22194413; PMCID: PMC3414261.
    99. Oh E, Becker AH, Sandikci A, Huber D, Chaba R, Gloge F, Nichols RJ, Typas A, Gross CA, Kramer G, Weissman J, Bukau B. Selective ribosome profiling reveals the cotranslational chaperone action of trigger factor in vivo. Cell. 2011 Dec 09; 147(6):1295-308. PMID: 22153074; PMCID: PMC3277850.
    100. El-Samad H, Weissman J. Genetics: Noise rules. Nature. 2011 Dec 07; 480(7376):188-9. PMID: 22158239.
      View in: PubMed
    101. Smith MH, Ploegh HL, Weissman J. Road to ruin: targeting proteins for degradation in the endoplasmic reticulum. Science. 2011 Nov 25; 334(6059):1086-90. PMID: 22116878; PMCID: PMC3864754.
    102. Roelants FM, Breslow DK, Muir A, Weissman J, Thorner J. Protein kinase Ypk1 phosphorylates regulatory proteins Orm1 and Orm2 to control sphingolipid homeostasis in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A. 2011 Nov 29; 108(48):19222-7. PMID: 22080611; PMCID: PMC3228448.
    103. Ingolia NT, Lareau LF, Weissman J. Ribosome profiling of mouse embryonic stem cells reveals the complexity and dynamics of mammalian proteomes. Cell. 2011 Nov 11; 147(4):789-802. PMID: 22056041; PMCID: PMC3225288.
    104. Hoppins S, Collins SR, Cassidy-Stone A, Hummel E, Devay RM, Lackner LL, Westermann B, Schuldiner M, Weissman J, Nunnari J. A mitochondrial-focused genetic interaction map reveals a scaffold-like complex required for inner membrane organization in mitochondria. J Cell Biol. 2011 Oct 17; 195(2):323-40. PMID: 21987634; PMCID: PMC3198156.
    105. Gracheva EO, Cordero-Morales JF, González-Carcacía JA, Ingolia NT, Manno C, Aranguren CI, Weissman J, Julius D. Ganglion-specific splicing of TRPV1 underlies infrared sensation in vampire bats. Nature. 2011 Aug 03; 476(7358):88-91. PMID: 21814281; PMCID: PMC3535012.
    106. Terzi N, Churchman LS, Vasiljeva L, Weissman J, Buratowski S. H3K4 trimethylation by Set1 promotes efficient termination by the Nrd1-Nab3-Sen1 pathway. Mol Cell Biol. 2011 Sep; 31(17):3569-83. PMID: 21709022; PMCID: PMC3165552.
    107. Verges KJ, Smith MH, Toyama BH, Weissman J. Strain conformation, primary structure and the propagation of the yeast prion [PSI+]. Nat Struct Mol Biol. 2011 Apr; 18(4):493-9. PMID: 21423194; PMCID: PMC3490428.
    108. Foo CK, Ohhashi Y, Kelly MJ, Tanaka M, Weissman J. Radically different amyloid conformations dictate the seeding specificity of a chimeric Sup35 prion. J Mol Biol. 2011 Apr 22; 408(1):1-8. PMID: 21333653; PMCID: PMC3070826.
    109. Churchman LS, Weissman J. Nascent transcript sequencing visualizes transcription at nucleotide resolution. Nature. 2011 Jan 20; 469(7330):368-73. PMID: 21248844; PMCID: PMC3880149.
    110. Toyama BH, Weissman J. Amyloid structure: conformational diversity and consequences. Annu Rev Biochem. 2011; 80:557-85. PMID: 21456964; PMCID: PMC3817101.
    111. Henry TC, Power JE, Kerwin CL, Mohammed A, Weissman J, Cameron DM, Wykoff DD. Systematic screen of Schizosaccharomyces pombe deletion collection uncovers parallel evolution of the phosphate signal transduction pathway in yeasts. Eukaryot Cell. 2011 Feb; 10(2):198-206. PMID: 21169418; PMCID: PMC3067400.
    112. Weissman J. The epistemology of cell biology. Mol Biol Cell. 2010 Nov 15; 21(22):3825. PMID: 21079033; PMCID: PMC2982092.
    113. Breslow DK, Weissman J. Membranes in balance: mechanisms of sphingolipid homeostasis. Mol Cell. 2010 Oct 22; 40(2):267-79. PMID: 20965421; PMCID: PMC2987644.
    114. Guo H, Ingolia NT, Weissman J, Bartel DP. Mammalian microRNAs predominantly act to decrease target mRNA levels. Nature. 2010 Aug 12; 466(7308):835-40. PMID: 20703300; PMCID: PMC2990499.
    115. Battle A, Jonikas MC, Walter P, Weissman J, Koller D. Automated identification of pathways from quantitative genetic interaction data. Mol Syst Biol. 2010 Jun 08; 6:379. PMID: 20531408; PMCID: PMC2913392.
    116. Springer M, Weissman J, Kirschner MW. A general lack of compensation for gene dosage in yeast. Mol Syst Biol. 2010 May 11; 6:368. PMID: 20461075; PMCID: PMC2890323.
    117. Vembar SS, Jonikas MC, Hendershot LM, Weissman J, Brodsky JL. J domain co-chaperone specificity defines the role of BiP during protein translocation. J Biol Chem. 2010 Jul 16; 285(29):22484-94. PMID: 20430885; PMCID: PMC2903355.
    118. Gracheva EO, Ingolia NT, Kelly YM, Cordero-Morales JF, Hollopeter G, Chesler AT, Sánchez EE, Perez JC, Weissman J, Julius D. Molecular basis of infrared detection by snakes. Nature. 2010 Apr 15; 464(7291):1006-11. PMID: 20228791; PMCID: PMC2855400.
    119. Breslow DK, Collins SR, Bodenmiller B, Aebersold R, Simons K, Shevchenko A, Ejsing CS, Weissman J. Orm family proteins mediate sphingolipid homeostasis. Nature. 2010 Feb 25; 463(7284):1048-53. PMID: 20182505; PMCID: PMC2877384.
    120. Ohhashi Y, Ito K, Toyama BH, Weissman J, Tanaka M. Differences in prion strain conformations result from non-native interactions in a nucleus. Nat Chem Biol. 2010 Mar; 6(3):225-230. PMID: 20081853.
      View in: PubMed
    121. Weissman J. Journal club. A biochemist looks at how DNA sequencing can reveal more than just sequences. Nature. 2009 Oct 29; 461(7268):1177. PMID: 19865125.
      View in: PubMed
    122. Collins SR, Weissman J, Krogan NJ. From information to knowledge: new technologies for defining gene function. Nat Methods. 2009 Oct; 6(10):721-23. PMID: 19953683; PMCID: PMC3066030.
    123. Hollien J, Lin JH, Li H, Stevens N, Walter P, Weissman J. Regulated Ire1-dependent decay of messenger RNAs in mammalian cells. J Cell Biol. 2009 Aug 10; 186(3):323-31. PMID: 19651891; PMCID: PMC2728407.
    124. Kornmann B, Currie E, Collins SR, Schuldiner M, Nunnari J, Weissman J, Walter P. An ER-mitochondria tethering complex revealed by a synthetic biology screen. Science. 2009 Jul 24; 325(5939):477-81. PMID: 19556461; PMCID: PMC2933203.
    125. Bassik MC, Lebbink RJ, Churchman LS, Ingolia NT, Patena W, LeProust EM, Schuldiner M, Weissman J, McManus MT. Rapid creation and quantitative monitoring of high coverage shRNA libraries. Nat Methods. 2009 Jun; 6(6):443-5. PMID: 19448642; PMCID: PMC2783737.
    126. Passos DO, Doma MK, Shoemaker CJ, Muhlrad D, Green R, Weissman J, Hollien J, Parker R. Analysis of Dom34 and its function in no-go decay. Mol Biol Cell. 2009 Jul; 20(13):3025-32. PMID: 19420139; PMCID: PMC2704154.
    127. Jonikas MC, Collins SR, Denic V, Oh E, Quan EM, Schmid V, Weibezahn J, Schwappach B, Walter P, Weissman J, Schuldiner M. Comprehensive characterization of genes required for protein folding in the endoplasmic reticulum. Science. 2009 Mar 27; 323(5922):1693-7. PMID: 19325107.
      View in: PubMed
    128. Fiedler D, Braberg H, Mehta M, Chechik G, Cagney G, Mukherjee P, Silva AC, Shales M, Collins SR, van Wageningen S, Kemmeren P, Holstege FC, Weissman J, Keogh MC, Koller D, Shokat KM, Krogan NJ. Functional organization of the S. cerevisiae phosphorylation network. Cell. 2009 Mar 06; 136(5):952-63. PMID: 19269370; PMCID: PMC2856666.
    129. Ingolia NT, Ghaemmaghami S, Newman JR, Weissman J. Genome-wide analysis in vivo of translation with nucleotide resolution using ribosome profiling. Science. 2009 Apr 10; 324(5924):218-23. PMID: 19213877; PMCID: PMC2746483.
    130. Quan EM, Kamiya Y, Kamiya D, Denic V, Weibezahn J, Kato K, Weissman J. Defining the glycan destruction signal for endoplasmic reticulum-associated degradation. Mol Cell. 2008 Dec 26; 32(6):870-7. PMID: 19111666; PMCID: PMC2873636.
    131. Wilmes GM, Bergkessel M, Bandyopadhyay S, Shales M, Braberg H, Cagney G, Collins SR, Whitworth GB, Kress TL, Weissman J, Ideker T, Guthrie C, Krogan NJ. A genetic interaction map of RNA-processing factors reveals links between Sem1/Dss1-containing complexes and mRNA export and splicing. Mol Cell. 2008 Dec 05; 32(5):735-46. PMID: 19061648; PMCID: PMC2644724.
    132. Tipton KA, Verges KJ, Weissman J. In vivo monitoring of the prion replication cycle reveals a critical role for Sis1 in delivering substrates to Hsp104. Mol Cell. 2008 Nov 21; 32(4):584-91. PMID: 19026788; PMCID: PMC2875781.
    133. Chechik G, Oh E, Rando O, Weissman J, Regev A, Koller D. Activity motifs reveal principles of timing in transcriptional control of the yeast metabolic network. Nat Biotechnol. 2008 Nov; 26(11):1251-9. PMID: 18953355; PMCID: PMC2651818.
    134. Roguev A, Bandyopadhyay S, Zofall M, Zhang K, Fischer T, Collins SR, Qu H, Shales M, Park HO, Hayles J, Hoe KL, Kim DU, Ideker T, Grewal SI, Weissman J, Krogan NJ. Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast. Science. 2008 Oct 17; 322(5900):405-10. PMID: 18818364; PMCID: PMC2753251.
    135. Typas A, Nichols RJ, Siegele DA, Shales M, Collins SR, Lim B, Braberg H, Yamamoto N, Takeuchi R, Wanner BL, Mori H, Weissman J, Krogan NJ, Gross CA. High-throughput, quantitative analyses of genetic interactions in E. coli. Nat Methods. 2008 Sep; 5(9):781-7. PMID: 19160513; PMCID: PMC2700713.
    136. Ingolia NT, Weissman J. Systems biology: Reverse engineering the cell. Nature. 2008 Aug 28; 454(7208):1059-62. PMID: 18756243.
      View in: PubMed
    137. Schuldiner M, Metz J, Schmid V, Denic V, Rakwalska M, Schmitt HD, Schwappach B, Weissman J. The GET complex mediates insertion of tail-anchored proteins into the ER membrane. Cell. 2008 Aug 22; 134(4):634-45. PMID: 18724936.
      View in: PubMed
    138. Breslow DK, Cameron DM, Collins SR, Schuldiner M, Stewart-Ornstein J, Newman HW, Braun S, Madhani HD, Krogan NJ, Weissman J. A comprehensive strategy enabling high-resolution functional analysis of the yeast genome. Nat Methods. 2008 Aug; 5(8):711-8. PMID: 18622397; PMCID: PMC2756093.
    139. Feng BY, Toyama BH, Wille H, Colby DW, Collins SR, May BC, Prusiner SB, Weissman J, Shoichet BK. Small-molecule aggregates inhibit amyloid polymerization. Nat Chem Biol. 2008 Mar; 4(3):197-9. PMID: 18223646; PMCID: PMC2730835.
    140. Haass FA, Jonikas M, Walter P, Weissman J, Jan YN, Jan LY, Schuldiner M. Identification of yeast proteins necessary for cell-surface function of a potassium channel. Proc Natl Acad Sci U S A. 2007 Nov 13; 104(46):18079-84. PMID: 17989219; PMCID: PMC2084299.
    141. Roguev A, Wiren M, Weissman J, Krogan NJ. High-throughput genetic interaction mapping in the fission yeast Schizosaccharomyces pombe. Nat Methods. 2007 Oct; 4(10):861-6. PMID: 17893680.
      View in: PubMed
    142. Toyama BH, Kelly MJ, Gross JD, Weissman J. The structural basis of yeast prion strain variants. Nature. 2007 Sep 13; 449(7159):233-7. PMID: 17767153.
      View in: PubMed
    143. Denic V, Weissman J. A molecular caliper mechanism for determining very long-chain fatty acid length. Cell. 2007 Aug 24; 130(4):663-77. PMID: 17719544.
      View in: PubMed
    144. Morrison AJ, Kim JA, Person MD, Highland J, Xiao J, Wehr TS, Hensley S, Bao Y, Shen J, Collins SR, Weissman J, Delrow J, Krogan NJ, Haber JE, Shen X. Mec1/Tel1 phosphorylation of the INO80 chromatin remodeling complex influences DNA damage checkpoint responses. Cell. 2007 Aug 10; 130(3):499-511. PMID: 17693258.
      View in: PubMed
    145. Ihmels J, Collins SR, Schuldiner M, Krogan NJ, Weissman J. Backup without redundancy: genetic interactions reveal the cost of duplicate gene loss. Mol Syst Biol. 2007; 3:86. PMID: 17389874; PMCID: PMC1847942.
    146. Laribee RN, Shibata Y, Mersman DP, Collins SR, Kemmeren P, Roguev A, Weissman J, Briggs SD, Krogan NJ, Strahl BD. CCR4/NOT complex associates with the proteasome and regulates histone methylation. Proc Natl Acad Sci U S A. 2007 Apr 03; 104(14):5836-41. PMID: 17389396; PMCID: PMC1851578.
    147. Collins SR, Miller KM, Maas NL, Roguev A, Fillingham J, Chu CS, Schuldiner M, Gebbia M, Recht J, Shales M, Ding H, Xu H, Han J, Ingvarsdottir K, Cheng B, Andrews B, Boone C, Berger SL, Hieter P, Zhang Z, Brown GW, Ingles CJ, Emili A, Allis CD, Toczyski DP, Weissman J, Greenblatt JF, Krogan NJ. Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction map. Nature. 2007 Apr 12; 446(7137):806-10. PMID: 17314980.
      View in: PubMed
    148. Collins SR, Kemmeren P, Zhao XC, Greenblatt JF, Spencer F, Holstege FC, Weissman J, Krogan NJ. Toward a comprehensive atlas of the physical interactome of Saccharomyces cerevisiae. Mol Cell Proteomics. 2007 Mar; 6(3):439-50. PMID: 17200106.
      View in: PubMed
    149. Newman JR, Weissman J. Systems biology: many things from one. Nature. 2006 Nov 30; 444(7119):561-2. PMID: 17122769.
      View in: PubMed
    150. Denic V, Quan EM, Weissman J. A luminal surveillance complex that selects misfolded glycoproteins for ER-associated degradation. Cell. 2006 Jul 28; 126(2):349-59. PMID: 16873065.
      View in: PubMed
    151. Hollien J, Weissman J. Decay of endoplasmic reticulum-localized mRNAs during the unfolded protein response. Science. 2006 Jul 07; 313(5783):104-7. PMID: 16825573.
      View in: PubMed
    152. Tanaka M, Collins SR, Toyama BH, Weissman J. The physical basis of how prion conformations determine strain phenotypes. Nature. 2006 Aug 03; 442(7102):585-9. PMID: 16810177.
      View in: PubMed
    153. Newman JR, Ghaemmaghami S, Ihmels J, Breslow DK, Noble M, DeRisi JL, Weissman J. Single-cell proteomic analysis of S. cerevisiae reveals the architecture of biological noise. Nature. 2006 Jun 15; 441(7095):840-6. PMID: 16699522.
      View in: PubMed
    154. Bukau B, Weissman J, Horwich A. Molecular chaperones and protein quality control. Cell. 2006 May 05; 125(3):443-51. PMID: 16678092.
      View in: PubMed
    155. Krogan NJ, Cagney G, Yu H, Zhong G, Guo X, Ignatchenko A, Li J, Pu S, Datta N, Tikuisis AP, Punna T, Peregrín-Alvarez JM, Shales M, Zhang X, Davey M, Robinson MD, Paccanaro A, Bray JE, Sheung A, Beattie B, Richards DP, Canadien V, Lalev A, Mena F, Wong P, Starostine A, Canete MM, Vlasblom J, Wu S, Orsi C, Collins SR, Chandran S, Haw R, Rilstone JJ, Gandi K, Thompson NJ, Musso G, St Onge P, Ghanny S, Lam MH, Butland G, Altaf-Ul AM, Kanaya S, Shilatifard A, O'Shea E, Weissman J, Ingles CJ, Hughes TR, Parkinson J, Gerstein M, Wodak SJ, Emili A, Greenblatt JF. Global landscape of protein complexes in the yeast Saccharomyces cerevisiae. Nature. 2006 Mar 30; 440(7084):637-43. PMID: 16554755.
      View in: PubMed
    156. Collins SR, Schuldiner M, Krogan NJ, Weissman J. A strategy for extracting and analyzing large-scale quantitative epistatic interaction data. Genome Biol. 2006; 7(7):R63. PMID: 16859555; PMCID: PMC1779568.
    157. Tanaka M, Weissman J. An efficient protein transformation protocol for introducing prions into yeast. Methods Enzymol. 2006; 412:185-200. PMID: 17046659.
      View in: PubMed
    158. Keogh MC, Kurdistani SK, Morris SA, Ahn SH, Podolny V, Collins SR, Schuldiner M, Chin K, Punna T, Thompson NJ, Boone C, Emili A, Weissman J, Hughes TR, Strahl BD, Grunstein M, Greenblatt JF, Buratowski S, Krogan NJ. Cotranscriptional set2 methylation of histone H3 lysine 36 recruits a repressive Rpd3 complex. Cell. 2005 Nov 18; 123(4):593-605. PMID: 16286008.
      View in: PubMed
    159. Kulp MS, Frickel EM, Ellgaard L, Weissman J. Domain architecture of protein-disulfide isomerase facilitates its dual role as an oxidase and an isomerase in Ero1p-mediated disulfide formation. J Biol Chem. 2006 Jan 13; 281(2):876-84. PMID: 16368681.
      View in: PubMed
    160. Schuldiner M, Collins SR, Thompson NJ, Denic V, Bhamidipati A, Punna T, Ihmels J, Andrews B, Boone C, Greenblatt JF, Weissman J, Krogan NJ. Exploration of the function and organization of the yeast early secretory pathway through an epistatic miniarray profile. Cell. 2005 Nov 04; 123(3):507-19. PMID: 16269340.
      View in: PubMed
    161. Bhamidipati A, Denic V, Quan EM, Weissman J. Exploration of the topological requirements of ERAD identifies Yos9p as a lectin sensor of misfolded glycoproteins in the ER lumen. Mol Cell. 2005 Sep 16; 19(6):741-51. PMID: 16168370.
      View in: PubMed
    162. Tanaka M, Chien P, Yonekura K, Weissman J. Mechanism of cross-species prion transmission: an infectious conformation compatible with two highly divergent yeast prion proteins. Cell. 2005 Apr 08; 121(1):49-62. PMID: 15820678.
      View in: PubMed
    163. Howson R, Huh WK, Ghaemmaghami S, Falvo JV, Bower K, Belle A, Dephoure N, Wykoff DD, Weissman J, O'Shea EK. Construction, verification and experimental use of two epitope-tagged collections of budding yeast strains. Comp Funct Genomics. 2005; 6(1-2):2-16. PMID: 18629296; PMCID: PMC2448600.
    164. Weissman J, O'Shea EK. 2004 Irving Sigal Young Investigator Award. Protein Sci. 2004 Dec; 13(12):3333-5. PMID: 15557272; PMCID: PMC2287319.
    165. Collins SR, Douglass A, Vale RD, Weissman J. Mechanism of prion propagation: amyloid growth occurs by monomer addition. PLoS Biol. 2004 Oct; 2(10):e321. PMID: 15383837; PMCID: PMC517824.
    166. Osherovich LZ, Cox BS, Tuite MF, Weissman J. Dissection and design of yeast prions. PLoS Biol. 2004 Apr; 2(4):E86. PMID: 15045026; PMCID: PMC374241.
    167. Tanaka M, Chien P, Naber N, Cooke R, Weissman J. Conformational variations in an infectious protein determine prion strain differences. Nature. 2004 Mar 18; 428(6980):323-8. PMID: 15029196.
      View in: PubMed
    168. Tu BP, Weissman J. Oxidative protein folding in eukaryotes: mechanisms and consequences. J Cell Biol. 2004 Feb 02; 164(3):341-6. PMID: 14757749; PMCID: PMC2172237.
    169. Chien P, Weissman J, DePace AH. Emerging principles of conformation-based prion inheritance. Annu Rev Biochem. 2004; 73:617-56. PMID: 15189155.
      View in: PubMed
    170. Ghaemmaghami S, Huh WK, Bower K, Howson RW, Belle A, Dephoure N, O'Shea EK, Weissman J. Global analysis of protein expression in yeast. Nature. 2003 Oct 16; 425(6959):737-41. PMID: 14562106.
      View in: PubMed
    171. Huh WK, Falvo JV, Gerke LC, Carroll AS, Howson RW, Weissman J, O'Shea EK. Global analysis of protein localization in budding yeast. Nature. 2003 Oct 16; 425(6959):686-91. PMID: 14562095.
      View in: PubMed
    172. Chien P, DePace AH, Collins SR, Weissman J. Generation of prion transmission barriers by mutational control of amyloid conformations. Nature. 2003 Aug 21; 424(6951):948-51. PMID: 12931190.
      View in: PubMed
    173. Wang JD, Herman C, Tipton KA, Gross CA, Weissman J. Directed evolution of substrate-optimized GroEL/S chaperonins. Cell. 2002 Dec 27; 111(7):1027-39. PMID: 12507429.
      View in: PubMed
    174. Tu BP, Weissman J. The FAD- and O(2)-dependent reaction cycle of Ero1-mediated oxidative protein folding in the endoplasmic reticulum. Mol Cell. 2002 Nov; 10(5):983-94. PMID: 12453408.
      View in: PubMed
    175. DePace AH, Weissman J. Origins and kinetic consequences of diversity in Sup35 yeast prion fibers. Nat Struct Biol. 2002 May; 9(5):389-96. PMID: 11938354.
      View in: PubMed
    176. Osherovich LZ, Weissman J. The utility of prions. Dev Cell. 2002 Feb; 2(2):143-51. PMID: 11832240.
      View in: PubMed