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Anatoly Urisman, MD, PhD

Title(s)Assistant Professor, Pathology
SchoolSchool of Medicine
ORCID ORCID Icon0000-0001-8364-5303 Additional info
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoM.D.2008 Medicine
    University of California, San FranciscoPh.D.2006 Graduate Division (Biomedical Sciences)
    University of California, BerkeleyBA1999Biochemistry

    Collapse Overview 
    Collapse Overview
    2008-2010 Residency in Anatomic Pathology, UCSF
    2010-2011 Pulmonary Pathology Fellowship, UCSF
    2011-2014 Research Fellow, Department of Pathology, UCSF
    2014-2016 Clinical Instructor, Department of Pathology, UCSF
    2016-now Assistant Professor, Department of Pathology, UCSF


    Research interests:
    My research is focused on understanding regulation of cell signaling by post-tranlational modifications in cancer cells. Specifically, we are using targeted proteomic techniques to study phosphorylation dynamics in key signaling networks such as EGFR, RAS/ERK, and AKT/mTOR. The studies are aimed at identifying key regulatory phosphorylation sites relevant to tumor development, progression, response to targeted therapies, and development of resistance. As part of this effort, we are working on novel approaches for quantifying site-specific phosphorylation of low-abundance proteins, such as transcription factors and other nuclear targets of the intracellular signal transduction pathways.

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Urisman A, Jones KD. Small Airway Disease: A Step Closer to Etiology-Based Classification of Bronchiolitis. Surg Pathol Clin. 2020 Mar; 13(1):189-196. PMID: 32005432.
      View in: PubMed
    2. Miao J, Kyoyama H, Liu L, Chan G, Wang Y, Urisman A, Yang YL, Liu S, Xu Z, Bin H, Li H, Jablons DM, You L. Inhibition of cyclin-dependent kinase 7 down-regulates yes-associated protein expression in mesothelioma cells. J Cell Mol Med. 2020 Jan; 24(1):1087-1098. PMID: 31755214.
      View in: PubMed
    3. Anatoly Urisman, Kirk D. Jones. Small Airway Disease A Step Closer to Etiology-Based Classification of Bronchiolitis. Surgical Pathology Clinics. 2019 Nov 1.
      View in: Publisher Site
    4. J. Rotow, A. Urisman, C. Mccoach, T. Jahan, T. Bivona, K. Jones, A. Gupta, H. Do, J. Riess, D. Aisner, R. Doebele, D. Jablons, J. Kratz, C. Blakely. P1.14-58 A Phase II Study to Evaluate Neoadjuvant Osimertinib for Surgically Resectable, EGFR-Mutant Non-Small Cell Lung Cancer. Journal of Thoracic Oncology. 2019 Oct 1; 14(10):s578.
      View in: Publisher Site
    5. Wang VE, Xue JY, Frederick DT, Cao Y, Lin E, Wilson C, Urisman A, Carbone DP, Flaherty KT, Bernards R, Lito P, Settleman J, McCormick F. Adaptive Resistance to Dual BRAF/MEK Inhibition in BRAF-Driven Tumors through Autocrine FGFR Pathway Activation. Clin Cancer Res. 2019 Dec 01; 25(23):7202-7217. PMID: 31515463.
      View in: PubMed
    6. Hsu PC, Tian B, Yang YL, Wang YC, Liu S, Urisman A, Yang CT, Xu Z, Jablons DM, You L. Cucurbitacin E inhibits the Yes-associated protein signaling pathway and suppresses brain metastasis of human non-small cell lung cancer in a murine model. Oncol Rep. 2019 Aug; 42(2):697-707. PMID: 31233205.
      View in: PubMed
    7. DeQuattro K, Urisman A, Margaretten M. A 36-Year-Old Man With Renal Failure, Fever, and Hypocomplementemia. Arthritis Care Res (Hoboken). 2019 04; 71(4):449-455. PMID: 30295438.
      View in: PubMed
    8. Castel P, Cheng A, Cuevas-Navarro A, Everman DB, Papageorge AG, Simanshu DK, Tankka A, Galeas J, Urisman A, McCormick F. RIT1 oncoproteins escape LZTR1-mediated proteolysis. Science. 2019 03 15; 363(6432):1226-1230. PMID: 30872527.
      View in: PubMed
    9. Wong AW, Urisman A, Burlingame AL, Shokat KM. Chemically reprogramming the phospho-transfer reaction to crosslink protein kinases to their substrates. Protein Sci. 2019 03; 28(3):654-662. PMID: 30636329.
      View in: PubMed
    10. Rotow JK, Woodard GA, Urisman A, McCoach CE, Bivona TG, Elicker BM, Jablons DM, Blakely CM. Pathologic Complete Response to Neoadjuvant Crizotinib in a Lung Adenocarcinoma Patient With a MET Exon 14 Skipping Mutation. Clin Lung Cancer. 2019 03; 20(2):e137-e141. PMID: 30553716.
      View in: PubMed
    11. Hung LY, Sen D, Oniskey TK, Katzen J, Cohen NA, Vaughan AE, Nieves W, Urisman A, Beers MF, Krummel MF, Herbert DR. Macrophages promote epithelial proliferation following infectious and non-infectious lung injury through a Trefoil factor 2-dependent mechanism. Mucosal Immunol. 2019 01; 12(1):64-76. PMID: 30337651.
      View in: PubMed
    12. Sahoo PK, Lee SJ, Jaiswal PB, Alber S, Kar AN, Miller-Randolph S, Taylor EE, Smith T, Singh B, Ho TS, Urisman A, Chand S, Pena EA, Burlingame AL, Woolf CJ, Fainzilber M, English AW, Twiss JL. Axonal G3BP1 stress granule protein limits axonal mRNA translation and nerve regeneration. Nat Commun. 2018 08 22; 9(1):3358. PMID: 30135423.
      View in: PubMed
    13. Ramirez JL, Urisman A, Kukreja J, Kratz JR. Surgical Management of Pulmonary Mucormycosis in Third-Trimester Pregnancy. Thorac Cardiovasc Surg Rep. 2018 Jan; 7(1):e27-e29. PMID: 29977735.
      View in: PubMed
    14. Hsu PC, Miao J, Huang Z, Yang YL, Xu Z, You J, Dai Y, Yeh CC, Chan G, Liu S, Urisman A, Yang CT, Jablons DM, You L. Inhibition of yes-associated protein suppresses brain metastasis of human lung adenocarcinoma in a murine model. J Cell Mol Med. 2018 06; 22(6):3073-3085. PMID: 29575527.
      View in: PubMed
    15. Terenzio M, Koley S, Samra N, Rishal I, Zhao Q, Sahoo PK, Urisman A, Marvaldi L, Oses-Prieto JA, Forester C, Gomes C, Kalinski AL, Di Pizio A, Doron-Mandel E, Perry RB, Koppel I, Twiss JL, Burlingame AL, Fainzilber M. Locally translated mTOR controls axonal local translation in nerve injury. Science. 2018 03 23; 359(6382):1416-1421. PMID: 29567716.
      View in: PubMed
    16. Forester CM, Zhao Q, Phillips NJ, Urisman A, Chalkley RJ, Oses-Prieto JA, Zhang L, Ruggero D, Burlingame AL. Revealing nascent proteomics in signaling pathways and cell differentiation. Proc Natl Acad Sci U S A. 2018 03 06; 115(10):2353-2358. PMID: 29467287.
      View in: PubMed
    17. Kirk D. Jones, Anatoly Urisman. Chapter 12 Histopathologic Approach to the Surgical Lung Biopsy in Interstitial Lung Disease. Interstitial Lung Disease. 2018 Jan 1; 141-155.
      View in: Publisher Site
    18. Wang VE, Urisman A, Albacker L, Ali S, Miller V, Aggarwal R, Jablons D. Checkpoint inhibitor is active against large cell neuroendocrine carcinoma with high tumor mutation burden. J Immunother Cancer. 2017 09 19; 5(1):75. PMID: 28923100.
      View in: PubMed
    19. Wang VE, Young L, Ali S, Miller VA, Urisman A, Wolfe J, Bivona TG, Damato B, Fogh S, Bergsland EK. A Case of Metastatic Atypical Neuroendocrine Tumor with ALK Translocation and Diffuse Brain Metastases. Oncologist. 2017 07; 22(7):768-773. PMID: 28507205.
      View in: PubMed
    20. Wang P, Jones KD, Urisman A, Elicker BM, Urbania T, Johannson KA, Assayag D, Lee J, Wolters PJ, Collard HR, Koth LL. Pathologic Findings and Prognosis in a Large Prospective Cohort of Chronic Hypersensitivity Pneumonitis. Chest. 2017 09; 152(3):502-509. PMID: 28223152.
      View in: PubMed
    21. Brownell R, Moua T, Henry TS, Elicker BM, White D, Vittinghoff E, Jones KD, Urisman A, Aravena C, Johannson KA, Golden JA, King TE, Wolters PJ, Collard HR, Ley B. The use of pretest probability increases the value of high-resolution CT in diagnosing usual interstitial pneumonia. Thorax. 2017 May; 72(5):424-429. PMID: 28082530.
      View in: PubMed
    22. Anatoly Urisman, Zoltan G. Laszik. Infection-Associated Thrombotic Microangiopathy. Bacterial Infections and the Kidney. 2017 Jan 1; 135-159.
      View in: Publisher Site
    23. Urisman A, Levin RS, Gordan JD, Webber JT, Hernandez H, Ishihama Y, Shokat KM, Burlingame AL. An Optimized Chromatographic Strategy for Multiplexing In Parallel Reaction Monitoring Mass Spectrometry: Insights from Quantitation of Activated Kinases. Mol Cell Proteomics. 2017 02; 16(2):265-277. PMID: 27940637.
      View in: PubMed
    24. Doll S, Urisman A, Oses-Prieto JA, Arnott D, Burlingame AL. Quantitative Proteomics Reveals Fundamental Regulatory Differences in Oncogenic HRAS and Isocitrate Dehydrogenase (IDH1) Driven Astrocytoma. Mol Cell Proteomics. 2017 01; 16(1):39-56. PMID: 27834733.
      View in: PubMed
    25. Lee S, Shang Y, Redmond SA, Urisman A, Tang AA, Li KH, Burlingame AL, Pak RA, Jovicic A, Gitler AD, Wang J, Gray NS, Seeley WW, Siddique T, Bigio EH, Lee VM, Trojanowski JQ, Chan JR, Huang EJ. Activation of HIPK2 Promotes ER Stress-Mediated Neurodegeneration in Amyotrophic Lateral Sclerosis. Neuron. 2016 07 06; 91(1):41-55. PMID: 27321923.
      View in: PubMed
    26. Fujita-Sato S, Galeas J, Truitt M, Pitt C, Urisman A, Bandyopadhyay S, Ruggero D, McCormick F. Enhanced MET Translation and Signaling Sustains K-Ras-Driven Proliferation under Anchorage-Independent Growth Conditions. Cancer Res. 2015 Jul 15; 75(14):2851-62. PMID: 25977330.
      View in: PubMed
    27. Urisman A, Jones KD. Pulmonary pathology in connective tissue disease. Semin Respir Crit Care Med. 2014 Apr; 35(2):201-12. PMID: 24668535.
      View in: PubMed
    28. Wiita AP, Ziv E, Wiita PJ, Urisman A, Julien O, Burlingame AL, Weissman JS, Wells JA. Global cellular response to chemotherapy-induced apoptosis. Elife. 2013 Oct 29; 2:e01236. PMID: 24171104.
      View in: PubMed
    29. J.R. Greenland, K.D. Jones, S.R. Hays, J.A. Golden, A. Urisman, N.P. Jewell, G.H. Caughey, N.N. Trivedi. Large-Airway Lymphocytic Bronchitis Predicts Bronchiolitis Obliterans Syndrome. The Journal of Heart and Lung Transplantation. 2013 Apr 1; 32(4):s59.
      View in: Publisher Site
    30. Greenland JR, Jones KD, Hays SR, Golden JA, Urisman A, Jewell NP, Caughey GH, Trivedi NN. Association of large-airway lymphocytic bronchitis with bronchiolitis obliterans syndrome. Am J Respir Crit Care Med. 2013 Feb 15; 187(4):417-23. PMID: 23239157.
      View in: PubMed
    31. Urisman, Anatoly MD, PhD; Jones, Kirk D. MD.Pathology Case Reviews. Pulmonary Crystal-Storing Histiocytosis: Two Cases and Review of the Literature. 2012; 17(5):186–191.
    32. Lee D, Das Gupta J, Gaughan C, Steffen I, Tang N, Luk KC, Qiu X, Urisman A, Fischer N, Molinaro R, Broz M, Schochetman G, Klein EA, Ganem D, Derisi JL, Simmons G, Hackett J, Silverman RH, Chiu CY. In-depth investigation of archival and prospectively collected samples reveals no evidence for XMRV infection in prostate cancer. PLoS One. 2012; 7(9):e44954. PMID: 23028701.
      View in: PubMed
    33. Urisman A, Leard LE, Nathan M, Elicker BM, Hoopes C, Kukreja J, Jones KD. Rapidly progressive pulmonary venoocclusive disease in young women taking oral contraceptives. J Heart Lung Transplant. 2012 Sep; 31(9):1031-6. PMID: 22884388.
      View in: PubMed
    34. Nijagal A, Jelin E, Feldstein VA, Courtier J, Urisman A, Jones KD, Lee H, Hirose S, MacKenzie TC. The diagnosis and management of intradiaphragmatic extralobar pulmonary sequestrations: a report of 4 cases. J Pediatr Surg. 2012 Aug; 47(8):1501-5. PMID: 22901907.
      View in: PubMed
    35. Jones KD, Urisman A. Histopathologic approach to the surgical lung biopsy in interstitial lung disease. Clin Chest Med. 2012 Mar; 33(1):27-40. PMID: 22365243.
      View in: PubMed
    36. Anatoly Urisman, Kirk D. Jones. Pulmonary Crystal-Storing Histiocytosis. AJSP Review and Reports. 2012 Jan 1; 17(5):186-191.
      View in: Publisher Site
    37. Chiu CY, Urisman A, Greenhow TL, Rouskin S, Yagi S, Schnurr D, Wright C, Drew WL, Wang D, Weintrub PS, Derisi JL, Ganem D. Utility of DNA microarrays for detection of viruses in acute respiratory tract infections in children. J Pediatr. 2008 Jul; 153(1):76-83. PMID: 18571541.
      View in: PubMed
    38. K. Fischer, A. Urisman, J. DeRisi. Diagnostic Techniques: Microarrays. Encyclopedia of Virology. 2008 Jan 1; (Clinical Infectious Diseases432006):14-18.
      View in: Publisher Site
    39. Chiu CY, Rouskin S, Koshy A, Urisman A, Fischer K, Yagi S, Schnurr D, Eckburg PB, Tompkins LS, Blackburn BG, Merker JD, Patterson BK, Ganem D, DeRisi JL. Microarray detection of human parainfluenzavirus 4 infection associated with respiratory failure in an immunocompetent adult. Clin Infect Dis. 2006 Oct 15; 43(8):e71-6. PMID: 16983602.
      View in: PubMed
    40. Eric A. Klein, Anatoly Urisman, Ross Molinaro, Nicole Fischer, Sarah Plummer, Graham Casey, Don Ganem, Joseph Dirisi, Robert Silverman. 239: Identification of a Novel Retrovirus in Prostate Tumors of Patients Homozygous for the R462Q Mutation in the HPC1 Gene. The Journal of Urology. 2006 Apr 1; 175(4):79.
      View in: Publisher Site
    41. Urisman A, Molinaro RJ, Fischer N, Plummer SJ, Casey G, Klein EA, Malathi K, Magi-Galluzzi C, Tubbs RR, Ganem D, Silverman RH, DeRisi JL. Identification of a novel Gammaretrovirus in prostate tumors of patients homozygous for R462Q RNASEL variant. PLoS Pathog. 2006 Mar; 2(3):e25. PMID: 16609730.
      View in: PubMed
    42. Urisman A, Fischer KF, Chiu CY, Kistler AL, Beck S, Wang D, DeRisi JL. E-Predict: a computational strategy for species identification based on observed DNA microarray hybridization patterns. Genome Biol. 2005; 6(9):R78. PMID: 16168085.
      View in: PubMed
    43. Wang D, Urisman A, Liu YT, Springer M, Ksiazek TG, Erdman DD, Mardis ER, Hickenbotham M, Magrini V, Eldred J, Latreille JP, Wilson RK, Ganem D, DeRisi JL. Viral discovery and sequence recovery using DNA microarrays. PLoS Biol. 2003 Nov; 1(2):E2. PMID: 14624234.
      View in: PubMed