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Anatoly Urisman, MD, PhD

Title(s)Assistant Professor, Pathology
SchoolSchool of Medicine
Address513 Parnassus Ave, MSB
San Francisco CA 94117
ORCID ORCID Icon0000-0001-8364-5303 Additional info
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoM.D.2008 Medicine
    University of California, San FranciscoPh.D.2006 Graduate Division (Biomedical Sciences)
    University of California, BerkeleyBA1999Biochemistry

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    2008-2010 Residency in Anatomic Pathology, UCSF
    2010-2011 Pulmonary Pathology Fellowship, UCSF
    2011-2014 Research Fellow, Department of Pathology, UCSF
    2014-2016 Clinical Instructor, Department of Pathology, UCSF
    2016-now Assistant Professor, Department of Pathology, UCSF


    Research interests:
    My research is focused on understanding regulation of cell signaling by post-tranlational modifications in cancer cells. Specifically, we are using targeted proteomic techniques to study phosphorylation dynamics in key signaling networks such as EGFR, RAS/ERK, and AKT/mTOR. The studies are aimed at identifying key regulatory phosphorylation sites relevant to tumor development, progression, response to targeted therapies, and development of resistance. As part of this effort, we are working on novel approaches for quantifying site-specific phosphorylation of low-abundance proteins, such as transcription factors and other nuclear targets of the intracellular signal transduction pathways.

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Therapy-Induced Evolution of Human Lung Cancer Revealed by Single-Cell RNA Sequencing. Cell. 2020 Aug 07. Maynard A, McCoach CE, Rotow JK, Harris L, Haderk F, Kerr DL, Yu EA, Schenk EL, Tan W, Zee A, Tan M, Gui P, Lea T, Wu W, Urisman A, Jones K, Sit R, Kolli PK, Seeley E, Gesthalter Y, Le DD, Yamauchi KA, Naeger DM, Bandyopadhyay S, Shah K, Cech L, Thomas NJ, Gupta A, Gonzalez M, Do H, Tan L, Bacaltos B, Gomez-Sjoberg R, Gubens M, Jahan T, Kratz JR, Jablons D, Neff N, Doebele RC, Weissman J, Blakely CM, Darmanis S, Bivona TG. PMID: 32822576.
      View in: PubMed   Mentions:    Fields:    
    2. Complement activation on endothelium initiates antibody-mediated acute lung injury. J Clin Invest. 2020 Jul 30. Cleary SJ, Kwaan N, Tian JJ, Calabrese DR, Mallavia B, Magnen M, Greenland JR, Urisman A, Singer JP, Hays SR, Kukreja J, Hay AM, Howie HL, Toy P, Lowell CA, Morrell CN, Zimring JC, Looney MR. PMID: 32730229.
      View in: PubMed   Mentions:    Fields:    
    3. Structural Insights into the SPRED1-Neurofibromin-KRAS Complex and Disruption of SPRED1-Neurofibromin Interaction by Oncogenic EGFR. Cell Rep. 2020 Jul 21; 32(3):107909. Yan W, Markegard E, Dharmaiah S, Urisman A, Drew M, Esposito D, Scheffzek K, Nissley DV, McCormick F, Simanshu DK. PMID: 32697994.
      View in: PubMed   Mentions:    Fields:    
    4. Small Airway Disease: A Step Closer to Etiology-Based Classification of Bronchiolitis. Surg Pathol Clin. 2020 Mar; 13(1):189-196. Urisman A, Jones KD. PMID: 32005432.
      View in: PubMed   Mentions:    Fields:    
    5. Inhibition of cyclin-dependent kinase 7 down-regulates yes-associated protein expression in mesothelioma cells. J Cell Mol Med. 2020 01; 24(1):1087-1098. Miao J, Kyoyama H, Liu L, Chan G, Wang Y, Urisman A, Yang YL, Liu S, Xu Z, Bin H, Li H, Jablons DM, You L. PMID: 31755214.
      View in: PubMed   Mentions: 1     Fields:    
    6. Small Airway Disease A Step Closer to Etiology-Based Classification of Bronchiolitis. Surgical Pathology Clinics. 2019 Nov 1. Anatoly Urisman, Kirk D. Jones. .
      View in: Publisher Site   Mentions:
    7. P1.14-58 A Phase II Study to Evaluate Neoadjuvant Osimertinib for Surgically Resectable, EGFR-Mutant Non-Small Cell Lung Cancer. Journal of Thoracic Oncology. 2019 Oct 1; 14(10):s578. J. Rotow, A. Urisman, C. Mccoach, T. Jahan, T. Bivona, K. Jones, A. Gupta, H. Do, J. Riess, D. Aisner, R. Doebele, D. Jablons, J. Kratz, C. Blakely. .
      View in: Publisher Site   Mentions:
    8. Adaptive Resistance to Dual BRAF/MEK Inhibition in BRAF-Driven Tumors through Autocrine FGFR Pathway Activation. Clin Cancer Res. 2019 12 01; 25(23):7202-7217. Wang VE, Xue JY, Frederick DT, Cao Y, Lin E, Wilson C, Urisman A, Carbone DP, Flaherty KT, Bernards R, Lito P, Settleman J, McCormick F. PMID: 31515463.
      View in: PubMed   Mentions:    Fields:    
    9. Cucurbitacin E inhibits the Yes-associated protein signaling pathway and suppresses brain metastasis of human non-small cell lung cancer in a murine model. Oncol Rep. 2019 Aug; 42(2):697-707. Hsu PC, Tian B, Yang YL, Wang YC, Liu S, Urisman A, Yang CT, Xu Z, Jablons DM, You L. PMID: 31233205.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    10. A 36-Year-Old Man With Renal Failure, Fever, and Hypocomplementemia. Arthritis Care Res (Hoboken). 2019 04; 71(4):449-455. DeQuattro K, Urisman A, Margaretten M. PMID: 30295438.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    11. RIT1 oncoproteins escape LZTR1-mediated proteolysis. Science. 2019 03 15; 363(6432):1226-1230. Castel P, Cheng A, Cuevas-Navarro A, Everman DB, Papageorge AG, Simanshu DK, Tankka A, Galeas J, Urisman A, McCormick F. PMID: 30872527.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    12. Chemically reprogramming the phospho-transfer reaction to crosslink protein kinases to their substrates. Protein Sci. 2019 03; 28(3):654-662. Wong AW, Urisman A, Burlingame AL, Shokat KM. PMID: 30636329.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    13. Pathologic Complete Response to Neoadjuvant Crizotinib in a Lung Adenocarcinoma Patient With a MET Exon 14 Skipping Mutation. Clin Lung Cancer. 2019 03; 20(2):e137-e141. Rotow JK, Woodard GA, Urisman A, McCoach CE, Bivona TG, Elicker BM, Jablons DM, Blakely CM. PMID: 30553716.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    14. Macrophages promote epithelial proliferation following infectious and non-infectious lung injury through a Trefoil factor 2-dependent mechanism. Mucosal Immunol. 2019 01; 12(1):64-76. Hung LY, Sen D, Oniskey TK, Katzen J, Cohen NA, Vaughan AE, Nieves W, Urisman A, Beers MF, Krummel MF, Herbert DR. PMID: 30337651.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    15. Axonal G3BP1 stress granule protein limits axonal mRNA translation and nerve regeneration. Nat Commun. 2018 08 22; 9(1):3358. Sahoo PK, Lee SJ, Jaiswal PB, Alber S, Kar AN, Miller-Randolph S, Taylor EE, Smith T, Singh B, Ho TS, Urisman A, Chand S, Pena EA, Burlingame AL, Woolf CJ, Fainzilber M, English AW, Twiss JL. PMID: 30135423.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    16. Surgical Management of Pulmonary Mucormycosis in Third-Trimester Pregnancy. Thorac Cardiovasc Surg Rep. 2018 Jan; 7(1):e27-e29. Ramirez JL, Urisman A, Kukreja J, Kratz JR. PMID: 29977735.
      View in: PubMed   Mentions:
    17. Inhibition of yes-associated protein suppresses brain metastasis of human lung adenocarcinoma in a murine model. J Cell Mol Med. 2018 06; 22(6):3073-3085. Hsu PC, Miao J, Huang Z, Yang YL, Xu Z, You J, Dai Y, Yeh CC, Chan G, Liu S, Urisman A, Yang CT, Jablons DM, You L. PMID: 29575527.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    18. Locally translated mTOR controls axonal local translation in nerve injury. Science. 2018 03 23; 359(6382):1416-1421. Terenzio M, Koley S, Samra N, Rishal I, Zhao Q, Sahoo PK, Urisman A, Marvaldi L, Oses-Prieto JA, Forester C, Gomes C, Kalinski AL, Di Pizio A, Doron-Mandel E, Perry RB, Koppel I, Twiss JL, Burlingame AL, Fainzilber M. PMID: 29567716.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    19. Revealing nascent proteomics in signaling pathways and cell differentiation. Proc Natl Acad Sci U S A. 2018 03 06; 115(10):2353-2358. Forester CM, Zhao Q, Phillips NJ, Urisman A, Chalkley RJ, Oses-Prieto JA, Zhang L, Ruggero D, Burlingame AL. PMID: 29467287.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    20. Chapter 12 Histopathologic Approach to the Surgical Lung Biopsy in Interstitial Lung Disease. Interstitial Lung Disease. 2018 Jan 1; 141-155. Kirk D. Jones, Anatoly Urisman. .
      View in: Publisher Site   Mentions:
    21. Checkpoint inhibitor is active against large cell neuroendocrine carcinoma with high tumor mutation burden. J Immunother Cancer. 2017 09 19; 5(1):75. Wang VE, Urisman A, Albacker L, Ali S, Miller V, Aggarwal R, Jablons D. PMID: 28923100.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    22. A Case of Metastatic Atypical Neuroendocrine Tumor with ALK Translocation and Diffuse Brain Metastases. Oncologist. 2017 07; 22(7):768-773. Wang VE, Young L, Ali S, Miller VA, Urisman A, Wolfe J, Bivona TG, Damato B, Fogh S, Bergsland EK. PMID: 28507205.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    23. Pathologic Findings and Prognosis in a Large Prospective Cohort of Chronic Hypersensitivity Pneumonitis. Chest. 2017 09; 152(3):502-509. Wang P, Jones KD, Urisman A, Elicker BM, Urbania T, Johannson KA, Assayag D, Lee J, Wolters PJ, Collard HR, Koth LL. PMID: 28223152.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    24. The use of pretest probability increases the value of high-resolution CT in diagnosing usual interstitial pneumonia. Thorax. 2017 May; 72(5):424-429. Brownell R, Moua T, Henry TS, Elicker BM, White D, Vittinghoff E, Jones KD, Urisman A, Aravena C, Johannson KA, Golden JA, King TE, Wolters PJ, Collard HR, Ley B. PMID: 28082530.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    25. Infection-Associated Thrombotic Microangiopathy. Bacterial Infections and the Kidney. 2017 Jan 1; 135-159. Anatoly Urisman, Zoltan G. Laszik. .
      View in: Publisher Site   Mentions:
    26. An Optimized Chromatographic Strategy for Multiplexing In Parallel Reaction Monitoring Mass Spectrometry: Insights from Quantitation of Activated Kinases. Mol Cell Proteomics. 2017 02; 16(2):265-277. Urisman A, Levin RS, Gordan JD, Webber JT, Hernandez H, Ishihama Y, Shokat KM, Burlingame AL. PMID: 27940637.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    27. Quantitative Proteomics Reveals Fundamental Regulatory Differences in Oncogenic HRAS and Isocitrate Dehydrogenase (IDH1) Driven Astrocytoma. Mol Cell Proteomics. 2017 01; 16(1):39-56. Doll S, Urisman A, Oses-Prieto JA, Arnott D, Burlingame AL. PMID: 27834733.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    28. Activation of HIPK2 Promotes ER Stress-Mediated Neurodegeneration in Amyotrophic Lateral Sclerosis. Neuron. 2016 07 06; 91(1):41-55. Lee S, Shang Y, Redmond SA, Urisman A, Tang AA, Li KH, Burlingame AL, Pak RA, Jovicic A, Gitler AD, Wang J, Gray NS, Seeley WW, Siddique T, Bigio EH, Lee VM, Trojanowski JQ, Chan JR, Huang EJ. PMID: 27321923.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    29. Enhanced MET Translation and Signaling Sustains K-Ras-Driven Proliferation under Anchorage-Independent Growth Conditions. Cancer Res. 2015 Jul 15; 75(14):2851-62. Fujita-Sato S, Galeas J, Truitt M, Pitt C, Urisman A, Bandyopadhyay S, Ruggero D, McCormick F. PMID: 25977330.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    30. Pulmonary pathology in connective tissue disease. Semin Respir Crit Care Med. 2014 Apr; 35(2):201-12. Urisman A, Jones KD. PMID: 24668535.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    31. Global cellular response to chemotherapy-induced apoptosis. Elife. 2013 Oct 29; 2:e01236. Wiita AP, Ziv E, Wiita PJ, Urisman A, Julien O, Burlingame AL, Weissman JS, Wells JA. PMID: 24171104.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    32. Large-Airway Lymphocytic Bronchitis Predicts Bronchiolitis Obliterans Syndrome. The Journal of Heart and Lung Transplantation. 2013 Apr 1; 32(4):s59. J.R. Greenland, K.D. Jones, S.R. Hays, J.A. Golden, A. Urisman, N.P. Jewell, G.H. Caughey, N.N. Trivedi. .
      View in: Publisher Site   Mentions:
    33. Association of large-airway lymphocytic bronchitis with bronchiolitis obliterans syndrome. Am J Respir Crit Care Med. 2013 Feb 15; 187(4):417-23. Greenland JR, Jones KD, Hays SR, Golden JA, Urisman A, Jewell NP, Caughey GH, Trivedi NN. PMID: 23239157.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    34. Pathology Case Reviews. Pulmonary Crystal-Storing Histiocytosis: Two Cases and Review of the Literature. 2012; 17(5):186–191. Urisman, Anatoly MD, PhD; Jones, Kirk D. MD.
    35. In-depth investigation of archival and prospectively collected samples reveals no evidence for XMRV infection in prostate cancer. PLoS One. 2012; 7(9):e44954. Lee D, Das Gupta J, Gaughan C, Steffen I, Tang N, Luk KC, Qiu X, Urisman A, Fischer N, Molinaro R, Broz M, Schochetman G, Klein EA, Ganem D, Derisi JL, Simmons G, Hackett J, Silverman RH, Chiu CY. PMID: 23028701.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    36. Rapidly progressive pulmonary venoocclusive disease in young women taking oral contraceptives. J Heart Lung Transplant. 2012 Sep; 31(9):1031-6. Urisman A, Leard LE, Nathan M, Elicker BM, Hoopes C, Kukreja J, Jones KD. PMID: 22884388.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    37. The diagnosis and management of intradiaphragmatic extralobar pulmonary sequestrations: a report of 4 cases. J Pediatr Surg. 2012 Aug; 47(8):1501-5. Nijagal A, Jelin E, Feldstein VA, Courtier J, Urisman A, Jones KD, Lee H, Hirose S, MacKenzie TC. PMID: 22901907.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    38. Histopathologic approach to the surgical lung biopsy in interstitial lung disease. Clin Chest Med. 2012 Mar; 33(1):27-40. Jones KD, Urisman A. PMID: 22365243.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    39. Pulmonary Crystal-Storing Histiocytosis. AJSP Review and Reports. 2012 Jan 1; 17(5):186-191. Anatoly Urisman, Kirk D. Jones. .
      View in: Publisher Site   Mentions:
    40. Utility of DNA microarrays for detection of viruses in acute respiratory tract infections in children. J Pediatr. 2008 Jul; 153(1):76-83. Chiu CY, Urisman A, Greenhow TL, Rouskin S, Yagi S, Schnurr D, Wright C, Drew WL, Wang D, Weintrub PS, Derisi JL, Ganem D. PMID: 18571541.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    41. Diagnostic Techniques: Microarrays. Encyclopedia of Virology. 2008 Jan 1; (Clinical Infectious Diseases432006):14-18. K. Fischer, A. Urisman, J. DeRisi. .
      View in: Publisher Site   Mentions:
    42. Microarray detection of human parainfluenzavirus 4 infection associated with respiratory failure in an immunocompetent adult. Clin Infect Dis. 2006 Oct 15; 43(8):e71-6. Chiu CY, Rouskin S, Koshy A, Urisman A, Fischer K, Yagi S, Schnurr D, Eckburg PB, Tompkins LS, Blackburn BG, Merker JD, Patterson BK, Ganem D, DeRisi JL. PMID: 16983602.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    43. 239: Identification of a Novel Retrovirus in Prostate Tumors of Patients Homozygous for the R462Q Mutation in the HPC1 Gene. The Journal of Urology. 2006 Apr 1; 175(4):79. Eric A. Klein, Anatoly Urisman, Ross Molinaro, Nicole Fischer, Sarah Plummer, Graham Casey, Don Ganem, Joseph Dirisi, Robert Silverman. .
      View in: Publisher Site   Mentions:
    44. Identification of a novel Gammaretrovirus in prostate tumors of patients homozygous for R462Q RNASEL variant. PLoS Pathog. 2006 Mar; 2(3):e25. Urisman A, Molinaro RJ, Fischer N, Plummer SJ, Casey G, Klein EA, Malathi K, Magi-Galluzzi C, Tubbs RR, Ganem D, Silverman RH, DeRisi JL. PMID: 16609730.
      View in: PubMed   Mentions: 286     Fields:    Translation:HumansCells
    45. E-Predict: a computational strategy for species identification based on observed DNA microarray hybridization patterns. Genome Biol. 2005; 6(9):R78. Urisman A, Fischer KF, Chiu CY, Kistler AL, Beck S, Wang D, DeRisi JL. PMID: 16168085.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    46. Viral discovery and sequence recovery using DNA microarrays. PLoS Biol. 2003 Nov; 1(2):E2. Wang D, Urisman A, Liu YT, Springer M, Ksiazek TG, Erdman DD, Mardis ER, Hickenbotham M, Magrini V, Eldred J, Latreille JP, Wilson RK, Ganem D, DeRisi JL. PMID: 14624234.
      View in: PubMed   Mentions: 155     Fields:    Translation:HumansCells
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