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    Xin Chen, PhD

    SchoolUCSF School of Pharmacy
    Address513 Parnassus Ave, Med Sci
    San Francisco CA 94143
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      Collapse Biography 
      Collapse Awards and Honors
      1991First Prize Award, Beijing Medical University, Beijing, China
      1998Postdoctoral Fellowship Award, Life Science Research Foundation, Baltimore, MD

      Collapse Overview 
      Collapse Overview
      My lab studies molecular genetics and signaling pathways during hepatic carcinogenesis. Specifically, using genomic approaches including expression arrays and array based CGH, we have identified large numbers of genes which are deregulated during liver cancer development. Using murine models, we are studying how these genetic alterations contribute to malignant transformation and progression in vivo. Our current studies focus on AKT/mTOR and Notch pathways and how they regulate cancer metabolism and cancer cell proliferation. In addition, using the novel mouse models as preclinical models, we are testing the therapeutic potentials of PI3K/mTOR or Notch inhibitors in treating liver cancers.

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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Chen X, Calvisi DF. Hydrodynamic transfection for generation of novel mouse models for liver cancer research. Am J Pathol. 2014 Apr; 184(4):912-23. PMID: 24480331; PMCID: PMC3969989.
      2. Cheung ST, Wong SY, Leung KL, Chen X, So S, Ng IO, Fan ST. Granulin-epithelin precursor overexpression promotes growth and invasion of hepatocellular carcinoma. Clin Cancer Res. 2004 Nov 15; 10(22):7629-36. PMID: 15569995.
        View in: PubMed
      3. Chen X, Higgins J, Cheung ST, Li R, Mason V, Montgomery K, Fan ST, van de Rijn M, So S. Novel endothelial cell markers in hepatocellular carcinoma. Mod Pathol. 2004 Oct; 17(10):1198-210. PMID: 15154008.
        View in: PubMed
      4. Leung SY, Yuen ST, Chu KM, Mathy JA, Li R, Chan AS, Law S, Wong J, Chen X, So S. Expression profiling identifies chemokine (C-C motif) ligand 18 as an independent prognostic indicator in gastric cancer. Gastroenterology. 2004 Aug; 127(2):457-69. PMID: 15300578.
        View in: PubMed
      5. West RB, Corless CL, Chen X, Rubin BP, Subramanian S, Montgomery K, Zhu S, Ball CA, Nielsen TO, Patel R, Goldblum JR, Brown PO, Heinrich MC, van de Rijn M. The novel marker, DOG1, is expressed ubiquitously in gastrointestinal stromal tumors irrespective of KIT or PDGFRA mutation status. Am J Pathol. 2004 Jul; 165(1):107-13. PMID: 15215166; PMCID: PMC1618538.
      6. Cui K, Tailor P, Liu H, Chen X, Ozato K, Zhao K. The chromatin-remodeling BAF complex mediates cellular antiviral activities by promoter priming. Mol Cell Biol. 2004 May; 24(10):4476-86. PMID: 15121865; PMCID: PMC400460.
      7. Sperger JM, Chen X, Draper JS, Antosiewicz JE, Chon CH, Jones SB, Brooks JD, Andrews PW, Brown PO, Thomson JA. Gene expression patterns in human embryonic stem cells and human pluripotent germ cell tumors. Proc Natl Acad Sci U S A. 2003 Nov 11; 100(23):13350-5. PMID: 14595015; PMCID: PMC263817.
      8. Chen X, Leung SY, Yuen ST, Chu KM, Ji J, Li R, Chan AS, Law S, Troyanskaya OG, Wong J, So S, Botstein D, Brown PO. Variation in gene expression patterns in human gastric cancers. Mol Biol Cell. 2003 Aug; 14(8):3208-15. PMID: 12925757; PMCID: PMC181561.
      9. Chua MS, Barry C, Chen X, Salvatierra O, Sarwal MM. Molecular profiling of anemia in acute renal allograft rejection using DNA microarrays. Am J Transplant. 2003 Jan; 3(1):17-22. PMID: 12492705.
        View in: PubMed
      10. Leung SY, Chen X, Chu KM, Yuen ST, Mathy J, Ji J, Chan AS, Li R, Law S, Troyanskaya OG, Tu IP, Wong J, So S, Botstein D, Brown PO. Phospholipase A2 group IIA expression in gastric adenocarcinoma is associated with prolonged survival and less frequent metastasis. Proc Natl Acad Sci U S A. 2002 Dec 10; 99(25):16203-8. PMID: 12456890; PMCID: PMC138589.
      11. Xu RH, Chen X, Li DS, Li R, Addicks GC, Glennon C, Zwaka TP, Thomson JA. BMP4 initiates human embryonic stem cell differentiation to trophoblast. Nat Biotechnol. 2002 Dec; 20(12):1261-4. PMID: 12426580.
        View in: PubMed
      12. Ji J, Chen X, Leung SY, Chi JT, Chu KM, Yuen ST, Li R, Chan AS, Li J, Dunphy N, So S. Comprehensive analysis of the gene expression profiles in human gastric cancer cell lines. Oncogene. 2002 Sep 19; 21(42):6549-56. PMID: 12226758.
        View in: PubMed
      13. Liu H, Kang H, Liu R, Chen X, Zhao K. Maximal induction of a subset of interferon target genes requires the chromatin-remodeling activity of the BAF complex. Mol Cell Biol. 2002 Sep; 22(18):6471-9. PMID: 12192045; PMCID: PMC135632.
      14. Cheung ST, Chen X, Guan XY, Wong SY, Tai LS, Ng IO, So S, Fan ST. Identify metastasis-associated genes in hepatocellular carcinoma through clonality delineation for multinodular tumor. Cancer Res. 2002 Aug 15; 62(16):4711-21. PMID: 12183430.
        View in: PubMed
      15. Chen X, Cheung ST, So S, Fan ST, Barry C, Higgins J, Lai KM, Ji J, Dudoit S, Ng IO, Van De Rijn M, Botstein D, Brown PO. Gene expression patterns in human liver cancers. Mol Biol Cell. 2002 Jun; 13(6):1929-39. PMID: 12058060; PMCID: PMC117615.
      16. Liu R, Liu H, Chen X, Kirby M, Brown PO, Zhao K. Regulation of CSF1 promoter by the SWI/SNF-like BAF complex. Cell. 2001 Aug 10; 106(3):309-18. PMID: 11509180.
        View in: PubMed
      17. Sarwal M, Chang S, Barry C, Chen X, Alizadeh A, Salvatierra O, Brown P. Genomic analysis of renal allograft dysfunction using cDNA microarrays. Transplant Proc. 2001 Feb-Mar; 33(1-2):297-8. PMID: 11266826.
        View in: PubMed
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