Xin Chen, PhD
|School||UCSF School of Pharmacy|
|Address||513 Parnassus Ave, Med Sci|
San Francisco CA 94143
|1991||First Prize Award, Beijing Medical University, Beijing, China|
|1998||Postdoctoral Fellowship Award, Life Science Research Foundation, Baltimore, MD|
My lab studies molecular genetics and signaling pathways during hepatic carcinogenesis. Specifically, using genomic approaches including expression arrays and array based CGH, we have identified large numbers of genes which are deregulated during liver cancer development. Using murine models, we are studying how these genetic alterations contribute to malignant transformation and progression in vivo. Our current studies focus on AKT/mTOR and Notch pathways and how they regulate cancer metabolism and cancer cell proliferation. In addition, using the novel mouse models as preclinical models, we are testing the therapeutic potentials of PI3K/mTOR or Notch inhibitors in treating liver cancers.
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