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Bruce Wang, MD

Title(s)Assistant Professor, Medicine
SchoolSchool of Medicine
ORCID ORCID Icon0000-0003-3486-5494 Additional info
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    Collapse Biography 
    Collapse Education and Training
    Stanford UniversityBAS2000Biological Sciences and Philosophy
    University of California San FranciscoM.D.2007School of Medicine
    University of California San FranciscoResidency2009Department of Medicine
    University of California San FranciscoFellowship2011Division of Gastroenterology
    Stanford University / HHMIPostdoctoral Fellow2016Developmental Biology (Lab of Roel Nusse)
    Collapse Awards and Honors
    Burroughs Wellcome Fund2016  - 2021Career Award for Medical Scientists
    UCSF School of Medicine2006Dean's Prize in Research

    Collapse Overview 
    Collapse Overview
    My lab studies how the different cell types in the liver, in particular the hepatocyte, are generated during development, patterned and maintained during adulthood, and regenerate after injury. Our long-term goals are to improve the understanding of liver disease pathophysiology and develop novel methods of treatment for liver diseases, including cell replacement therapy. Currently, we have two major research focuses: 1) understanding the biology of adult hepatocyte stem cells and 2) developing a liver cell atlas. We take innovative and integrated approaches to address these two areas using the tools of stem cell biology, developmental biology, genomics and tissue engineering.

    I also study the porphyrias, a group of inherited diseases related to defects in heme synthesis pathway. I am a member of the Porphyrias Consortium, a NIH sponsored Rare Disease Clinical Research Consortium. The purpose of the network is to integrate translational studies of the porphyrias with clinical trials testing new therapeutics.

    Collapse Research 
    Collapse Research Activities and Funding
    Preclinical development of human hepatocyte progenitor cells for cell therapy
    CIRM DISC2-09565Jun 1, 2017 - May 31, 2019
    Role: Co-Principle Investigator
    Wnt signaling in hepatocyte homeostasis
    NIH/NIDDK K08DK101603Mar 15, 2015 - Feb 29, 2020
    Role: Principal Investigator
    Stem cell niche and Wnt in liver injury and regeneration.
    NIH/NIDDK F32DK091005Jul 14, 2011 - Jul 13, 2014
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials
    Collapse Featured Publications
    Collapse Websites
    Collapse Student Projects

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Alkhani A, Levy CS, Tsui M, Rosenberg KA, Polovina K, Mattis AN, Mack M, Van Dyken S, Wang BM, Maher JJ, Nijagal A. Ly6cLo non-classical monocytes promote resolution of rhesus rotavirus-mediated perinatal hepatic inflammation. Sci Rep. 2020 Apr 28; 10(1):7165. PMID: 32346042.
      View in: PubMed
    2. Qiao Y, Wang J, Karagoz E, Liang B, Song X, Shang R, Evert K, Xu M, Che L, Evert M, Calvisi DF, Tao J, Wang B, Monga SP, Chen X. Axis inhibition protein 1 (Axin1) Deletion-Induced Hepatocarcinogenesis Requires Intact ß-Catenin but Not Notch Cascade in Mice. Hepatology. 2019 Dec; 70(6):2003-2017. PMID: 30737831.
      View in: PubMed
    3. Zhao L, Jin Y, Donahue K, Tsui M, Fish M, Logan CY, Wang B, Nusse R. Tissue Repair in the Mouse Liver Following Acute Carbon Tetrachloride Depends on Injury-Induced Wnt/ß-Catenin Signaling. Hepatology. 2019 Jun; 69(6):2623-2635. PMID: 30762896.
      View in: PubMed
    4. Wang B, Rudnick S, Cengia B, Bonkovsky HL. Acute Hepatic Porphyrias: Review and Recent Progress. Hepatol Commun. 2019 Feb; 3(2):193-206. PMID: 30766957.
      View in: PubMed
    5. Peng WC, Logan CY, Fish M, Anbarchian T, Aguisanda F, Álvarez-Varela A, Wu P, Jin Y, Zhu J, Li B, Grompe M, Wang B, Nusse R. Inflammatory Cytokine TNFa Promotes the Long-Term Expansion of Primary Hepatocytes in 3D Culture. Cell. 2018 11 29; 175(6):1607-1619.e15. PMID: 30500539.
      View in: PubMed
    6. Single-cell transcriptomics of 20 mouse organs creates a Tabula Muris. Nature. 2018 10; 562(7727):367-372. PMID: 30283141.
      View in: PubMed
    7. Balwani M, Wang B, Anderson KE, Bloomer JR, Bissell DM, Bonkovsky HL, Phillips JD, Desnick RJ. Acute hepatic porphyrias: Recommendations for evaluation and long-term management. Hepatology. 2017 10; 66(4):1314-1322. PMID: 28605040.
      View in: PubMed
    8. Balwani M, Naik H, Anderson KE, Bissell DM, Bloomer J, Bonkovsky HL, Phillips JD, Overbey JR, Wang B, Singal AK, Liu LU, Desnick RJ. Clinical, Biochemical, and Genetic Characterization of North American Patients With Erythropoietic Protoporphyria and X-linked Protoporphyria. JAMA Dermatol. 2017 08 01; 153(8):789-796. PMID: 28614581.
      View in: PubMed
    9. Gou EW, Balwani M, Bissell DM, Bloomer JR, Bonkovsky HL, Desnick RJ, Naik H, Phillips JD, Singal AK, Wang B, Keel S, Anderson KE. Pitfalls in Erythrocyte Protoporphyrin Measurement for Diagnosis and Monitoring of Protoporphyrias. Clin Chem. 2015 Dec; 61(12):1453-6. PMID: 26482161.
      View in: PubMed
    10. Wang B, Zhao L, Fish M, Logan CY, Nusse R. Self-renewing diploid Axin2(+) cells fuel homeostatic renewal of the liver. Nature. 2015 Aug 13; 524(7564):180-5. PMID: 26245375.
      View in: PubMed
    11. Bissell DM, Wang B. Acute Hepatic Porphyria. J Clin Transl Hepatol. 2015 Mar; 3(1):17-26. PMID: 26357631.
      View in: PubMed
    12. Cascino MD, McNabb B, Gardner DG, Woeber KA, Fox AN, Wang B, Fix OK. Acute liver failure with thyrotoxicosis treated with liver transplantation. Endocr Pract. 2013 May-Jun; 19(3):e57-60. PMID: 23337142.
      View in: PubMed
    13. Malato Y, Naqvi S, Schürmann N, Ng R, Wang B, Zape J, Kay MA, Grimm D, Willenbring H. Fate tracing of mature hepatocytes in mouse liver homeostasis and regeneration. J Clin Invest. 2011 Dec; 121(12):4850-60. PMID: 22105172.
      View in: PubMed
    14. Wang B, Dolinski BM, Kikuchi N, Leone DR, Peters MG, Weinreb PH, Violette SM, Bissell DM. Role of alphavbeta6 integrin in acute biliary fibrosis. Hepatology. 2007 Nov; 46(5):1404-12. PMID: 17924447.
      View in: PubMed
    15. Wang B, Dhaliwal G, Sleisenger MH. Six decades of progress and change in hospital medicine, 1947-2007. Pharos Alpha Omega Alpha Honor Med Soc. 2007; 70(1):10-5. PMID: 17357747.
      View in: PubMed
    16. Jakubowski A, Ambrose C, Parr M, Lincecum JM, Wang MZ, Zheng TS, Browning B, Michaelson JS, Baetscher M, Baestcher M, Wang B, Bissell DM, Burkly LC. TWEAK induces liver progenitor cell proliferation. J Clin Invest. 2005 Sep; 115(9):2330-40. PMID: 16110324.
      View in: PubMed
    17. Winter CG, Wang B, Ballew A, Royou A, Karess R, Axelrod JD, Luo L. Drosophila Rho-associated kinase (Drok) links Frizzled-mediated planar cell polarity signaling to the actin cytoskeleton. Cell. 2001 Apr 06; 105(1):81-91. PMID: 11301004.
      View in: PubMed