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Bruce Wang, MD

Title(s)Assistant Professor, Medicine
SchoolSchool of Medicine
Phone415-476-6160
ORCID ORCID Icon0000-0003-3486-5494 Additional info
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    Collapse Biography 
    Collapse Education and Training
    Stanford UniversityBAS2000Biological Sciences and Philosophy
    University of California San FranciscoM.D.2007School of Medicine
    University of California San FranciscoResidency2009Department of Medicine
    University of California San FranciscoFellowship2011Division of Gastroenterology
    Stanford University / HHMIPostdoctoral Fellow2016Developmental Biology (Lab of Roel Nusse)
    Collapse Awards and Honors
    Burroughs Wellcome Fund2016Career Award for Medical Scientists
    UCSF School of Medicine2006Dean's Prize in Research

    Collapse Overview 
    Collapse Overview
    My lab studies how the different cell types in the liver, in particular the hepatocyte, are generated during development, patterned and maintained during adulthood, and regenerate after injury. Our long-term goals are to improve the understanding of liver disease pathophysiology and develop novel methods of treatment for liver diseases, including cell replacement therapy. Currently, we have two major research focuses: 1) understanding the biology of adult hepatocyte stem cells and 2) developing a liver cell atlas. We take innovative and integrated approaches to address these two areas using the tools of stem cell biology, developmental biology, genomics and tissue engineering.

    I also study the porphyrias, a group of inherited diseases related to defects in heme synthesis pathway. I am a member of the Porphyrias Consortium, a NIH sponsored Rare Disease Clinical Research Consortium. The purpose of the network is to integrate translational studies of the porphyrias with clinical trials testing new therapeutics.

    Collapse Research 
    Collapse Research Activities and Funding
    Single cell resolution atlas of liver inflammation
    Chan Zuckerberg Initiative Sep 1, 2020 - Aug 31, 2022
    Role: Principle Investigator
    Preclinical development of human hepatocyte progenitor cells for cell therapy
    CIRM DISC2-09565Jun 1, 2017 - May 31, 2019
    Role: Co-Principle Investigator
    Wnt signaling and hepatocyte stem cells in liver homeostasis and cancer
    Burroughs Wellcome Fund CAMSJan 1, 2017 - Dec 31, 2021
    Role: Principle Investigator
    Wnt signaling in hepatocyte homeostasis
    NIH/NIDDK K08DK101603Mar 15, 2015 - Feb 29, 2020
    Role: Principal Investigator
    Stem cell niche and Wnt in liver injury and regeneration.
    NIH/NIDDK F32DK091005Jul 14, 2011 - Jul 13, 2014
    Role: Principal Investigator
    Porphyrias Consortium
    NIH U54DK083909Sep 30, 2009 - Aug 31, 2024
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials
    Collapse Featured Publications
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Hepatocellular Carcinoma in Acute Hepatic Porphyrias: Results from the Longitudinal Study of the U.S. Porphyrias Consortium. Hepatology. 2020 Jul 18. Saberi B, Naik H, Overbey JR, Erwin AL, Anderson KE, Bissell DM, Bonkovsky HL, Phillips JD, Wang B, K Singal A, M McGuire B, Desnick RJ, Balwani M. PMID: 32681675.
      View in: PubMed   Mentions:    Fields:    
    2. A single-cell transcriptomic atlas characterizes ageing tissues in the mouse. Nature. 2020 Jul; 583(7817):590-595. PMID: 32669714.
      View in: PubMed   Mentions: 6     Fields:    
    3. Ageing hallmarks exhibit organ-specific temporal signatures. Nature. 2020 07; 583(7817):596-602. Schaum N, Lehallier B, Hahn O, Pálovics R, Hosseinzadeh S, Lee SE, Sit R, Lee DP, Losada PM, Zardeneta ME, Fehlmann T, Webber JT, McGeever A, Calcuttawala K, Zhang H, Berdnik D, Mathur V, Tan W, Zee A, Tan M, Pisco AO, Karkanias J, Neff NF, Keller A, Darmanis S, Quake SR, Wyss-Coray T. PMID: 32669715.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    4. Phase 3 Trial of RNAi Therapeutic Givosiran for Acute Intermittent Porphyria. N Engl J Med. 2020 06 11; 382(24):2289-2301. Balwani M, Sardh E, Ventura P, Peiró PA, Rees DC, Stölzel U, Bissell DM, Bonkovsky HL, Windyga J, Anderson KE, Parker C, Silver SM, Keel SB, Wang JD, Stein PE, Harper P, Vassiliou D, Wang B, Phillips J, Ivanova A, Langendonk JG, Kauppinen R, Minder E, Horie Y, Penz C, Chen J, Liu S, Ko JJ, Sweetser MT, Garg P, Vaishnaw A, Kim JB, Simon AR, Gouya L. PMID: 32521132.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCTClinical Trials
    5. Ly6cLo non-classical monocytes promote resolution of rhesus rotavirus-mediated perinatal hepatic inflammation. Sci Rep. 2020 04 28; 10(1):7165. Alkhani A, Levy CS, Tsui M, Rosenberg KA, Polovina K, Mattis AN, Mack M, Van Dyken S, Wang BM, Maher JJ, Nijagal A. PMID: 32346042.
      View in: PubMed   Mentions:    Fields:    
    6. mTORC2 Signaling Is Necessary for Timely Liver Regeneration after Partial Hepatectomy. Am J Pathol. 2020 04; 190(4):817-829. Xu M, Wang H, Wang J, Burhan D, Shang R, Wang P, Zhou Y, Li R, Liang B, Evert K, Utpatel K, Xu Z, Song X, Che L, Calvisi DF, Wang B, Chen X, Zeng Y, Chen X. PMID: 32035060.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    7. Evaluating the Patient-Reported Outcomes Measurement Information System scales in acute intermittent porphyria. Genet Med. 2020 03; 22(3):590-597. Naik H, Overbey JR, Montgomery GH, Winkel G, Balwani M, Anderson KE, Bissell DM, Bonkovsky HL, Phillips JD, Wang B, McGuire B, Keel S, Levy C, Erwin A, Desnick RJ. PMID: 31690837.
      View in: PubMed   Mentions:    Fields:    
    8. Evaluating quality of life tools in North American patients with erythropoietic protoporphyria and X-linked protoporphyria. JIMD Rep. 2019 Nov; 50(1):9-19. Naik H, Overbey JR, Desnick RJ, Anderson KE, Bissell DM, Bloomer J, Bonkovsky HL, Phillips JD, Wang B, Singal A, Balwani M. PMID: 31741822.
      View in: PubMed   Mentions:
    9. Axis inhibition protein 1 (Axin1) Deletion-Induced Hepatocarcinogenesis Requires Intact ß-Catenin but Not Notch Cascade in Mice. Hepatology. 2019 12; 70(6):2003-2017. Qiao Y, Wang J, Karagoz E, Liang B, Song X, Shang R, Evert K, Xu M, Che L, Evert M, Calvisi DF, Tao J, Wang B, Monga SP, Chen X. PMID: 30737831.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    10. Tissue Repair in the Mouse Liver Following Acute Carbon Tetrachloride Depends on Injury-Induced Wnt/ß-Catenin Signaling. Hepatology. 2019 06; 69(6):2623-2635. Zhao L, Jin Y, Donahue K, Tsui M, Fish M, Logan CY, Wang B, Nusse R. PMID: 30762896.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    11. Acute Hepatic Porphyrias: Review and Recent Progress. Hepatol Commun. 2019 Feb; 3(2):193-206. Wang B, Rudnick S, Cengia B, Bonkovsky HL. PMID: 30766957.
      View in: PubMed   Mentions:
    12. Inflammatory Cytokine TNFa Promotes the Long-Term Expansion of Primary Hepatocytes in 3D Culture. Cell. 2018 11 29; 175(6):1607-1619.e15. Peng WC, Logan CY, Fish M, Anbarchian T, Aguisanda F, Álvarez-Varela A, Wu P, Jin Y, Zhu J, Li B, Grompe M, Wang B, Nusse R. PMID: 30500539.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    13. Single-cell transcriptomics of 20 mouse organs creates a Tabula Muris. Nature. 2018 10; 562(7727):367-372. PMID: 30283141.
      View in: PubMed   Mentions: 165     Fields:    Translation:AnimalsCells
    14. Acute hepatic porphyrias: Recommendations for evaluation and long-term management. Hepatology. 2017 10; 66(4):1314-1322. Balwani M, Wang B, Anderson KE, Bloomer JR, Bissell DM, Bonkovsky HL, Phillips JD, Desnick RJ. PMID: 28605040.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    15. Clinical, Biochemical, and Genetic Characterization of North American Patients With Erythropoietic Protoporphyria and X-linked Protoporphyria. JAMA Dermatol. 2017 08 01; 153(8):789-796. Balwani M, Naik H, Anderson KE, Bissell DM, Bloomer J, Bonkovsky HL, Phillips JD, Overbey JR, Wang B, Singal AK, Liu LU, Desnick RJ. PMID: 28614581.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    16. Pitfalls in Erythrocyte Protoporphyrin Measurement for Diagnosis and Monitoring of Protoporphyrias. Clin Chem. 2015 Dec; 61(12):1453-6. Gou EW, Balwani M, Bissell DM, Bloomer JR, Bonkovsky HL, Desnick RJ, Naik H, Phillips JD, Singal AK, Wang B, Keel S, Anderson KE. PMID: 26482161.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    17. Self-renewing diploid Axin2(+) cells fuel homeostatic renewal of the liver. Nature. 2015 Aug 13; 524(7564):180-5. Wang B, Zhao L, Fish M, Logan CY, Nusse R. PMID: 26245375.
      View in: PubMed   Mentions: 145     Fields:    Translation:AnimalsCells
    18. Acute Hepatic Porphyria. J Clin Transl Hepatol. 2015 Mar; 3(1):17-26. Bissell DM, Wang B. PMID: 26357631.
      View in: PubMed   Mentions:
    19. Acute liver failure with thyrotoxicosis treated with liver transplantation. Endocr Pract. 2013 May-Jun; 19(3):e57-60. Cascino MD, McNabb B, Gardner DG, Woeber KA, Fox AN, Wang B, Fix OK. PMID: 23337142.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    20. Fate tracing of mature hepatocytes in mouse liver homeostasis and regeneration. J Clin Invest. 2011 Dec; 121(12):4850-60. Malato Y, Naqvi S, Schürmann N, Ng R, Wang B, Zape J, Kay MA, Grimm D, Willenbring H. PMID: 22105172.
      View in: PubMed   Mentions: 137     Fields:    Translation:AnimalsCells
    21. Role of alphavbeta6 integrin in acute biliary fibrosis. Hepatology. 2007 Nov; 46(5):1404-12. Wang B, Dolinski BM, Kikuchi N, Leone DR, Peters MG, Weinreb PH, Violette SM, Bissell DM. PMID: 17924447.
      View in: PubMed   Mentions: 70     Fields:    Translation:AnimalsCells
    22. Six decades of progress and change in hospital medicine, 1947-2007. Pharos Alpha Omega Alpha Honor Med Soc. 2007; 70(1):10-5. Wang B, Dhaliwal G, Sleisenger MH. PMID: 17357747.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    23. TWEAK induces liver progenitor cell proliferation. J Clin Invest. 2005 Sep; 115(9):2330-40. Jakubowski A, Ambrose C, Parr M, Lincecum JM, Wang MZ, Zheng TS, Browning B, Michaelson JS, Baetscher M, Baestcher M, Wang B, Bissell DM, Burkly LC. PMID: 16110324.
      View in: PubMed   Mentions: 146     Fields:    Translation:HumansAnimalsCells
    24. Drosophila Rho-associated kinase (Drok) links Frizzled-mediated planar cell polarity signaling to the actin cytoskeleton. Cell. 2001 Apr 06; 105(1):81-91. Winter CG, Wang B, Ballew A, Royou A, Karess R, Axelrod JD, Luo L. PMID: 11301004.
      View in: PubMed   Mentions: 198     Fields:    Translation:AnimalsCells
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