Bruce Wang, MD

Title(s)Assistant Professor, Medicine
SchoolSchool of Medicine
Phone415-476-6160
ORCID ORCID Icon0000-0003-3486-5494 Additional info
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    Collapse Biography 
    Collapse Education and Training
    Stanford UniversityBAS2000Biological Sciences and Philosophy
    University of California San FranciscoM.D.2007School of Medicine
    University of California San FranciscoResidency2009Department of Medicine
    University of California San FranciscoFellowship2011Division of Gastroenterology
    Stanford University / HHMIPostdoctoral Fellow2016Developmental Biology (Lab of Roel Nusse)
    Collapse Awards and Honors
    Burroughs Wellcome Fund2016Career Award for Medical Scientists
    UCSF School of Medicine2006Dean's Prize in Research

    Collapse Overview 
    Collapse Overview
    My lab studies how the different cell types in the liver, in particular the hepatocyte, are generated during development, patterned and maintained during adulthood, and regenerate after injury. Our long-term goals are to improve the understanding of liver disease pathophysiology and develop novel methods of treatment for liver diseases, including cell replacement therapy. Currently, we have two major research focuses: 1) understanding the biology of adult hepatocyte stem cells and 2) developing a liver cell atlas. We take innovative and integrated approaches to address these two areas using the tools of stem cell biology, developmental biology, genomics and tissue engineering.

    I also study the porphyrias, a group of inherited diseases related to defects in heme synthesis pathway. I am a member of the Porphyrias Consortium, a NIH sponsored Rare Disease Clinical Research Consortium. The purpose of the network is to integrate translational studies of the porphyrias with clinical trials testing new therapeutics.

    Collapse Research 
    Collapse Research Activities and Funding
    Single cell resolution atlas of liver inflammation
    Chan Zuckerberg Initiative Sep 1, 2020 - Aug 31, 2022
    Role: Principle Investigator
    Porphyrias Consortium
    NIH U54DK083909Sep 30, 2009 - Aug 31, 2024
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials
    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Polygenic enrichment distinguishes disease associations of individual cells in single-cell RNA-seq data. Nat Genet. 2022 Sep 01. Zhang MJ, Hou K, Dey KK, Sakaue S, Jagadeesh KA, Weinand K, Taychameekiatchai A, Rao P, Pisco AO, Zou J, Wang B, Gandal M, Raychaudhuri S, Pasaniuc B, Price AL. PMID: 36050550.
      View in: PubMed   Mentions:
    2. Evidence-based consensus guidelines for the diagnosis and management of erythropoietic protoporphyria and X-linked protoporphyria. J Am Acad Dermatol. 2022 Aug 27. Dickey AK, Naik H, Keel SB, Levy C, Beaven SW, Elmariah SB, Erwin AL, Goddu RJ, Hedstrom K, Leaf RK, Kazamel M, Mazepa M, Philpotts LL, Quigley J, Raef H, Rudnick SR, Saberi B, Thapar M, Ungar J, Wang B, Balwani M, Porphyrias Consortium of the Rare Diseases Clinical Research Network. PMID: 36041558.
      View in: PubMed   Mentions:
    3. Disease burden in patients with acute hepatic porphyria: experience from the phase 3 ENVISION study. Orphanet J Rare Dis. 2022 08 26; 17(1):327. Wang B, Ventura P, Takase KI, Thapar M, Cassiman D, Kubisch I, Liu S, Sweetser MT, Balwani M. PMID: 36028858; PMCID: PMC9419398.
      View in: PubMed   Mentions:
    4. Single-cell analysis of hepatoblastoma identifies tumor signatures that predict chemotherapy susceptibility using patient-specific tumor spheroids. Nat Commun. 2022 Aug 25; 13(1):4878. Song H, Bucher S, Rosenberg K, Tsui M, Burhan D, Hoffman D, Cho SJ, Rangaswami A, Breese M, Leung S, Ventura MVP, Sweet-Cordero EA, Huang FW, Nijagal A, Wang B. PMID: 36008377; PMCID: PMC9411569.
      View in: PubMed   Mentions:
    5. The Tabula Sapiens: A multiple-organ, single-cell transcriptomic atlas of humans. Science. 2022 05 13; 376(6594):eabl4896. Tabula Sapiens Consortium*, Jones RC, Karkanias J, Krasnow MA, Pisco AO, Quake SR, Salzman J, Yosef N, Bulthaup B, Brown P, Harper W, Hemenez M, Ponnusamy R, Salehi A, Sanagavarapu BA, Spallino E, Aaron KA, Concepcion W, Gardner JM, Kelly B, Neidlinger N, Wang Z, Crasta S, Kolluru S, Morri M, Pisco AO, Tan SY, Travaglini KJ, Xu C, Alcántara-Hernández M, Almanzar N, Antony J, Beyersdorf B, Burhan D, Calcuttawala K, Carter MM, Chan CKF, Chang CA, Chang S, Colville A, Crasta S, Culver RN, Cvijovic I, D'Amato G, Ezran C, Galdos FX, Gillich A, Goodyer WR, Hang Y, Hayashi A, Houshdaran S, Huang X, Irwin JC, Jang S, Juanico JV, Kershner AM, Kim S, Kiss B, Kolluru S, Kong W, Kumar ME, Kuo AH, Leylek R, Li B, Loeb GB, Lu WJ, Mantri S, Markovic M, McAlpine PL, de Morree A, Morri M, Mrouj K, Mukherjee S, Muser T, Neuhöfer P, Nguyen TD, Perez K, Phansalkar R, Pisco AO, Puluca N, Qi Z, Rao P, Raquer-McKay H, Schaum N, Scott B, Seddighzadeh B, Segal J, Sen S, Sikandar S, Spencer SP, Steffes LC, Subramaniam VR, Swarup A, Swift M, Travaglini KJ, Van Treuren W, Trimm E, Veizades S, Vijayakumar S, Vo KC, Vorperian SK, Wang W, Weinstein HNW, Winkler J, Wu TTH, Xie J, Yung AR, Zhang Y, Detweiler AM, Mekonen H, Neff NF, Sit RV, Tan M, Yan J, Bean GR, Charu V, Forgó E, Martin BA, Ozawa MG, Silva O, Tan SY, Toland A, Vemuri VNP, Afik S, Awayan K, Botvinnik OB, Byrne A, Chen M, Dehghannasiri R, Detweiler AM, Gayoso A, Granados AA, Li Q, Mahmoudabadi G, McGeever A, de Morree A, Olivieri JE, Park M, Pisco AO, Ravikumar N, Salzman J, Stanley G, Swift M, Tan M, Tan W, Tarashansky AJ, Vanheusden R, Vorperian SK, Wang P, Wang S, Xing G, Xu C, Yosef N, Alcántara-Hernández M, Antony J, Chan CKF, Chang CA, Colville A, Crasta S, Culver R, Dethlefsen L, Ezran C, Gillich A, Hang Y, Ho PY, Irwin JC, Jang S, Kershner AM, Kong W, Kumar ME, Kuo AH, Leylek R, Liu S, Loeb GB, Lu WJ, Maltzman JS, Metzger RJ, de Morree A, Neuhöfer P, Perez K, Phansalkar R, Qi Z, Rao P, Raquer-McKay H, Sasagawa K, Scott B, Sinha R, Song H, Spencer SP, Swarup A, Swift M, Travaglini KJ, Trimm E, Veizades S, Vijayakumar S, Wang B, Wang W, Winkler J, Xie J, Yung AR, Artandi SE, Beachy PA, Clarke MF, Giudice LC, Huang FW, Huang KC, Idoyaga J, Kim SK, Krasnow M, Kuo CS, Nguyen P, Quake SR, Rando TA, Red-Horse K, Reiter J, Relman DA, Sonnenburg JL, Wang B, Wu A, Wu SM, Wyss-Coray T. PMID: 35549404.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    6. Single-cell analysis of human primary prostate cancer reveals the heterogeneity of tumor-associated epithelial cell states. Nat Commun. 2022 01 10; 13(1):141. Song H, Weinstein HNW, Allegakoen P, Wadsworth MH, Xie J, Yang H, Castro EA, Lu KL, Stohr BA, Feng FY, Carroll PR, Wang B, Cooperberg MR, Shalek AK, Huang FW. PMID: 35013146; PMCID: PMC8748675.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    7. Human alveolar type 2 epithelium transdifferentiates into metaplastic KRT5+ basal cells. Nat Cell Biol. 2022 01; 24(1):10-23. Kathiriya JJ, Wang C, Zhou M, Brumwell A, Cassandras M, Le Saux CJ, Cohen M, Alysandratos KD, Wang B, Wolters P, Matthay M, Kotton DN, Chapman HA, Peng T. PMID: 34969962; PMCID: PMC8761168.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    8. RNA splicing programs define tissue compartments and cell types at single-cell resolution. Elife. 2021 09 13; 10. Olivieri JE, Dehghannasiri R, Wang PL, Jang S, de Morree A, Tan SY, Ming J, Ruohao Wu A, Tabula Sapiens Consortium, Quake SR, Krasnow MA, Salzman J. PMID: 34515025; PMCID: PMC8563012.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    9. Novel treatment options for acute hepatic porphyrias. Curr Opin Gastroenterol. 2021 05 01; 37(3):194-199. Wang B. PMID: 33769375; PMCID: PMC8104969.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    10. The acute hepatic porphyrias. Transl Gastroenterol Hepatol. 2021; 6:24. Wang B. PMID: 33824928; PMCID: PMC7838531.
      View in: PubMed   Mentions: 3  
    11. TBX3 functions as a tumor suppressor downstream of activated CTNNB1 mutants during hepatocarcinogenesis. J Hepatol. 2021 07; 75(1):120-131. Liang B, Zhou Y, Qian M, Xu M, Wang J, Zhang Y, Song X, Wang H, Lin S, Ren C, Monga SP, Wang B, Evert M, Chen Y, Chen X, Huang Z, Calvisi DF, Chen X. PMID: 33577921; PMCID: PMC8217095.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    12. Pituitary stem cells produce paracrine WNT signals to control the expansion of their descendant progenitor cells. Elife. 2021 01 05; 10. Russell JP, Lim X, Santambrogio A, Yianni V, Kemkem Y, Wang B, Fish M, Haston S, Grabek A, Hallang S, Lodge EJ, Patist AL, Schedl A, Mollard P, Nusse R, Andoniadou CL. PMID: 33399538; PMCID: PMC7803373.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    13. Hepatocellular Carcinoma in Acute Hepatic Porphyrias: Results from the Longitudinal Study of the U.S. Porphyrias Consortium. Hepatology. 2021 05; 73(5):1736-1746. Saberi B, Naik H, Overbey JR, Erwin AL, Anderson KE, Bissell DM, Bonkovsky HL, Phillips JD, Wang B, K Singal A, M McGuire B, Desnick RJ, Balwani M. PMID: 32681675.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    14. Evidence in the UK Biobank for the underdiagnosis of erythropoietic protoporphyria. Genet Med. 2021 01; 23(1):140-148. Dickey AK, Quick C, Ducamp S, Zhu Z, Feng YA, Naik H, Balwani M, Anderson KE, Lin X, Phillips JE, Rebeiz L, Bonkovsky HL, McGuire BM, Wang B, Chasman DI, Smoller JW, Fleming MD, Christiani DC. PMID: 32873934; PMCID: PMC7796935.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    15. A single-cell transcriptomic atlas characterizes ageing tissues in the mouse. Nature. 2020 07; 583(7817):590-595. Tabula Muris Consortium. PMID: 32669714; PMCID: PMC8240505.
      View in: PubMed   Mentions: 122     Fields:    Translation:AnimalsCells
    16. Ageing hallmarks exhibit organ-specific temporal signatures. Nature. 2020 07; 583(7817):596-602. Schaum N, Lehallier B, Hahn O, Pálovics R, Hosseinzadeh S, Lee SE, Sit R, Lee DP, Losada PM, Zardeneta ME, Fehlmann T, Webber JT, McGeever A, Calcuttawala K, Zhang H, Berdnik D, Mathur V, Tan W, Zee A, Tan M, Tabula Muris Consortium, Pisco AO, Karkanias J, Neff NF, Keller A, Darmanis S, Quake SR, Wyss-Coray T. PMID: 32669715; PMCID: PMC7757734.
      View in: PubMed   Mentions: 69     Fields:    Translation:AnimalsCells
    17. Phase 3 Trial of RNAi Therapeutic Givosiran for Acute Intermittent Porphyria. N Engl J Med. 2020 06 11; 382(24):2289-2301. Balwani M, Sardh E, Ventura P, Peiró PA, Rees DC, Stölzel U, Bissell DM, Bonkovsky HL, Windyga J, Anderson KE, Parker C, Silver SM, Keel SB, Wang JD, Stein PE, Harper P, Vassiliou D, Wang B, Phillips J, Ivanova A, Langendonk JG, Kauppinen R, Minder E, Horie Y, Penz C, Chen J, Liu S, Ko JJ, Sweetser MT, Garg P, Vaishnaw A, Kim JB, Simon AR, Gouya L, ENVISION Investigators. PMID: 32521132.
      View in: PubMed   Mentions: 94     Fields:    Translation:HumansCTClinical Trials
    18. Ly6cLo non-classical monocytes promote resolution of rhesus rotavirus-mediated perinatal hepatic inflammation. Sci Rep. 2020 04 28; 10(1):7165. Alkhani A, Levy CS, Tsui M, Rosenberg KA, Polovina K, Mattis AN, Mack M, Van Dyken S, Wang BM, Maher JJ, Nijagal A. PMID: 32346042; PMCID: PMC7188847.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    19. mTORC2 Signaling Is Necessary for Timely Liver Regeneration after Partial Hepatectomy. Am J Pathol. 2020 04; 190(4):817-829. Xu M, Wang H, Wang J, Burhan D, Shang R, Wang P, Zhou Y, Li R, Liang B, Evert K, Utpatel K, Xu Z, Song X, Che L, Calvisi DF, Wang B, Chen X, Zeng Y, Chen X. PMID: 32035060; PMCID: PMC7180798.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    20. Evaluating the Patient-Reported Outcomes Measurement Information System scales in acute intermittent porphyria. Genet Med. 2020 03; 22(3):590-597. Naik H, Overbey JR, Montgomery GH, Winkel G, Balwani M, Anderson KE, Bissell DM, Bonkovsky HL, Phillips JD, Wang B, McGuire B, Keel S, Levy C, Erwin A, Desnick RJ. PMID: 31690837; PMCID: PMC7060090.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCTClinical Trials
    21. Evaluating quality of life tools in North American patients with erythropoietic protoporphyria and X-linked protoporphyria. JIMD Rep. 2019 Nov; 50(1):9-19. Naik H, Overbey JR, Desnick RJ, Anderson KE, Bissell DM, Bloomer J, Bonkovsky HL, Phillips JD, Wang B, Singal A, Balwani M. PMID: 31741822; PMCID: PMC6850979.
      View in: PubMed   Mentions: 4  
    22. Axis inhibition protein 1 (Axin1) Deletion-Induced Hepatocarcinogenesis Requires Intact β-Catenin but Not Notch Cascade in Mice. Hepatology. 2019 12; 70(6):2003-2017. Qiao Y, Wang J, Karagoz E, Liang B, Song X, Shang R, Evert K, Xu M, Che L, Evert M, Calvisi DF, Tao J, Wang B, Monga SP, Chen X. PMID: 30737831; PMCID: PMC7206928.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    23. Tissue Repair in the Mouse Liver Following Acute Carbon Tetrachloride Depends on Injury-Induced Wnt/β-Catenin Signaling. Hepatology. 2019 06; 69(6):2623-2635. Zhao L, Jin Y, Donahue K, Tsui M, Fish M, Logan CY, Wang B, Nusse R. PMID: 30762896; PMCID: PMC7043939.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    24. Acute Hepatic Porphyrias: Review and Recent Progress. Hepatol Commun. 2019 Feb; 3(2):193-206. Wang B, Rudnick S, Cengia B, Bonkovsky HL. PMID: 30766957; PMCID: PMC6357830.
      View in: PubMed   Mentions: 29     Fields:    
    25. Inflammatory Cytokine TNFα Promotes the Long-Term Expansion of Primary Hepatocytes in 3D Culture. Cell. 2018 11 29; 175(6):1607-1619.e15. Peng WC, Logan CY, Fish M, Anbarchian T, Aguisanda F, Álvarez-Varela A, Wu P, Jin Y, Zhu J, Li B, Grompe M, Wang B, Nusse R. PMID: 30500539; PMCID: PMC6497386.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansAnimalsCells
    26. Single-cell transcriptomics of 20 mouse organs creates a Tabula Muris. Nature. 2018 10; 562(7727):367-372. Tabula Muris Consortium, Overall coordination, Logistical coordination, Organ collection and processing, Library preparation and sequencing, Computational data analysis, Cell type annotation, Writing group, Supplemental text writing group, Principal investigators. PMID: 30283141; PMCID: PMC6642641.
      View in: PubMed   Mentions: 598     Fields:    Translation:AnimalsCells
    27. Acute hepatic porphyrias: Recommendations for evaluation and long-term management. Hepatology. 2017 10; 66(4):1314-1322. Balwani M, Wang B, Anderson KE, Bloomer JR, Bissell DM, Bonkovsky HL, Phillips JD, Desnick RJ, Porphyrias Consortium of the Rare Diseases Clinical Research Network. PMID: 28605040; PMCID: PMC5605422.
      View in: PubMed   Mentions: 35     Fields:    Translation:Humans
    28. Clinical, Biochemical, and Genetic Characterization of North American Patients With Erythropoietic Protoporphyria and X-linked Protoporphyria. JAMA Dermatol. 2017 08 01; 153(8):789-796. Balwani M, Naik H, Anderson KE, Bissell DM, Bloomer J, Bonkovsky HL, Phillips JD, Overbey JR, Wang B, Singal AK, Liu LU, Desnick RJ. PMID: 28614581; PMCID: PMC5710403.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    29. Pitfalls in Erythrocyte Protoporphyrin Measurement for Diagnosis and Monitoring of Protoporphyrias. Clin Chem. 2015 Dec; 61(12):1453-6. Gou EW, Balwani M, Bissell DM, Bloomer JR, Bonkovsky HL, Desnick RJ, Naik H, Phillips JD, Singal AK, Wang B, Keel S, Anderson KE. PMID: 26482161; PMCID: PMC4744648.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    30. Self-renewing diploid Axin2(+) cells fuel homeostatic renewal of the liver. Nature. 2015 Aug 13; 524(7564):180-5. Wang B, Zhao L, Fish M, Logan CY, Nusse R. PMID: 26245375; PMCID: PMC4589224.
      View in: PubMed   Mentions: 265     Fields:    Translation:AnimalsCells
    31. Acute Hepatic Porphyria. J Clin Transl Hepatol. 2015 Mar; 3(1):17-26. Bissell DM, Wang B. PMID: 26357631; PMCID: PMC4542079.
      View in: PubMed   Mentions: 15  
    32. Acute liver failure with thyrotoxicosis treated with liver transplantation. Endocr Pract. 2013 May-Jun; 19(3):e57-60. Cascino MD, McNabb B, Gardner DG, Woeber KA, Fox AN, Wang B, Fix OK. PMID: 23337142.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    33. Fate tracing of mature hepatocytes in mouse liver homeostasis and regeneration. J Clin Invest. 2011 Dec; 121(12):4850-60. Malato Y, Naqvi S, Schürmann N, Ng R, Wang B, Zape J, Kay MA, Grimm D, Willenbring H. PMID: 22105172; PMCID: PMC3226005.
      View in: PubMed   Mentions: 187     Fields:    Translation:AnimalsCells
    34. Role of alphavbeta6 integrin in acute biliary fibrosis. Hepatology. 2007 Nov; 46(5):1404-12. Wang B, Dolinski BM, Kikuchi N, Leone DR, Peters MG, Weinreb PH, Violette SM, Bissell DM. PMID: 17924447; PMCID: PMC4144397.
      View in: PubMed   Mentions: 82     Fields:    Translation:AnimalsCells
    35. Six decades of progress and change in hospital medicine, 1947-2007. Pharos Alpha Omega Alpha Honor Med Soc. 2007; 70(1):10-5. Wang B, Dhaliwal G, Sleisenger MH. PMID: 17357747.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    36. TWEAK induces liver progenitor cell proliferation. J Clin Invest. 2005 Sep; 115(9):2330-40. Jakubowski A, Ambrose C, Parr M, Lincecum JM, Wang MZ, Zheng TS, Browning B, Michaelson JS, Baetscher M, Baestcher M, Wang B, Bissell DM, Burkly LC. PMID: 16110324; PMCID: PMC1187931.
      View in: PubMed   Mentions: 167     Fields:    Translation:HumansAnimalsCells
    37. Drosophila Rho-associated kinase (Drok) links Frizzled-mediated planar cell polarity signaling to the actin cytoskeleton. Cell. 2001 Apr 06; 105(1):81-91. Winter CG, Wang B, Ballew A, Royou A, Karess R, Axelrod JD, Luo L. PMID: 11301004.
      View in: PubMed   Mentions: 232     Fields:    Translation:AnimalsCells
    38. Hereditary Coproporphyria. GeneReviews®. 1993. Wang B, Bissell DM. View Publication.
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