Loading...

John Gordan, MD, PhD

TitleAssistant Professor
InstitutionUniversity of California San Francisco
DepartmentMedicine
Address550 16th. Street
San Francisco CA 94158
Phone415-353-9888
vCardDownload vCard

    Collapse Biography 
    Collapse Education and Training
    Harvard College, Boston, MAAB6/2001Biochemistry
    University of Pennsylvania, Philadelphia, PAPhD12/2007Cancer Biology
    University of Pennsylvania, Philadelphia, PAMD5/2009

    Collapse Overview 

    Collapse ORNG Applications 
    Collapse Clinical Trials
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Song X, Liu X, Wang H, Wang J, Qiao Y, Cigliano A, Utpatel K, Ribback S, Pilo MG, Serra M, Gordan J, Che L, Zhang S, Cossu A, Porcu A, Pascale RM, Dombrowski F, Hu H, Calvisi DF, Evert M, Chen X. Combined CDK4/6 and pan-mTOR inhibition is synergistic against intrahepatic cholangiocarcinoma. Clin Cancer Res. 2018 Jul 03. PMID: 30084835.
      View in: PubMed
    2. Donnella HJ, Webber JT, Levin RS, Camarda R, Momcilovic O, Bayani N, Shah KN, Korkola JE, Shokat KM, Goga A, Gordan J, Bandyopadhyay S. Kinome rewiring reveals AURKA limits PI3K-pathway inhibitor efficacy in breast cancer. Nat Chem Biol. 2018 Jun 25. PMID: 29942081.
      View in: PubMed
    3. Lim HC, Montesion M, Botton T, Collisson EA, Umetsu SE, Behr SC, Gordan J, Stephens PJ, Kelley RK. Hybrid Capture-Based Tumor Sequencing and Copy Number Analysis to Confirm Origin of Metachronous Metastases in BRCA1-Mutant Cholangiocarcinoma Harboring a Novel YWHAZ-BRAF Fusion. Oncologist. 2018 Apr 05. PMID: 29622700.
      View in: PubMed
    4. Wang J, Dong M, Xu Z, Song X, Zhang S, Qiao Y, Che L, Gordan J, Hu K, Liu Y, Calvisi DF, Chen X. Notch2 controls hepatocyte-derived cholangiocarcinoma formation in mice. Oncogene. 2018 Mar 16. PMID: 29545603.
      View in: PubMed
    5. Rajaram S, Heinrich LE, Gordan J, Avva J, Bonness KM, Witkiewicz AK, Malter JS, Atreya CE, Warren RS, Wu LF, Altschuler SJ. Sampling strategies to capture single-cell heterogeneity. Nat Methods. 2017 Oct; 14(10):967-970. PMID: 28869755.
      View in: PubMed
    6. Zhang S, Song X, Cao D, Xu Z, Fan B, Che L, Hu J, Chen B, Dong M, Pilo MG, Cigliano A, Evert K, Ribback S, Dombrowski F, Pascale RM, Cossu A, Vidili G, Porcu A, Simile MM, Pes GM, Giannelli G, Gordan J, Wei L, Evert M, Cong W, Calvisi DF, Chen X. Pan-mTOR inhibitor MLN0128 is effective against intrahepatic cholangiocarcinoma in mice. J Hepatol. 2017 Dec; 67(6):1194-1203. PMID: 28733220.
      View in: PubMed
    7. Urisman A, Levin RS, Gordan J, Webber JT, Hernandez H, Ishihama Y, Shokat KM, Burlingame AL. An Optimized Chromatographic Strategy for Multiplexing In Parallel Reaction Monitoring Mass Spectrometry: Insights from Quantitation of Activated Kinases. Mol Cell Proteomics. 2017 02; 16(2):265-277. PMID: 27940637.
      View in: PubMed
    8. Miller RE, Brough R, Bajrami I, Williamson CT, McDade S, Campbell J, Kigozi A, Rafiq R, Pemberton H, Natrajan R, Joel J, Astley H, Mahoney C, Moore JD, Torrance C, Gordan J, Webber JT, Levin RS, Shokat KM, Bandyopadhyay S, Lord CJ, Ashworth A. Synthetic Lethal Targeting of ARID1A-Mutant Ovarian Clear Cell Tumors with Dasatinib. Mol Cancer Ther. 2016 07; 15(7):1472-84. PMID: 27364904.
      View in: PubMed
    9. Saha SK, Gordan J, Kleinstiver BP, Vu P, Najem MS, Yeo JC, Shi L, Kato Y, Levin RS, Webber JT, Damon LJ, Egan RK, Greninger P, McDermott U, Garnett MJ, Jenkins RL, Rieger-Christ KM, Sullivan TB, Hezel AF, Liss AS, Mizukami Y, Goyal L, Ferrone CR, Zhu AX, Joung JK, Shokat KM, Benes CH, Bardeesy N. Isocitrate Dehydrogenase Mutations Confer Dasatinib Hypersensitivity and SRC Dependence in Intrahepatic Cholangiocarcinoma. Cancer Discov. 2016 07; 6(7):727-39. PMID: 27231123.
      View in: PubMed
    10. Evason KJ, Francisco MT, Juric V, Balakrishnan S, Lopez Pazmino Mdel P, Gordan J, Kakar S, Spitsbergen J, Goga A, Stainier DY. Identification of Chemical Inhibitors of ß-Catenin-Driven Liver Tumorigenesis in Zebrafish. PLoS Genet. 2015 Jul; 11(7):e1005305. PMID: 26134322; PMCID: PMC4489858.
    11. Martins MM, Zhou AY, Corella A, Horiuchi D, Yau C, Rakshandehroo T, Gordan J, Levin RS, Johnson J, Jascur J, Shales M, Sorrentino A, Cheah J, Clemons PA, Shamji AF, Schreiber SL, Krogan NJ, Shokat KM, McCormick F, Goga A, Bandyopadhyay S. Linking tumor mutations to drug responses via a quantitative chemical-genetic interaction map. Cancer Discov. 2015 Feb; 5(2):154-67. PMID: 25501949; PMCID: PMC4407699.
    12. Sos ML, Levin RS, Gordan J, Oses-Prieto JA, Webber JT, Salt M, Hann B, Burlingame AL, McCormick F, Bandyopadhyay S, Shokat KM. Oncogene mimicry as a mechanism of primary resistance to BRAF inhibitors. Cell Rep. 2014 Aug 21; 8(4):1037-48. PMID: 25127139; PMCID: PMC4294625.
    13. Dondeti VR, Wubbenhorst B, Lal P, Gordan J, D'Andrea K, Attiyeh EF, Simon MC, Nathanson KL. Integrative genomic analyses of sporadic clear cell renal cell carcinoma define disease subtypes and potential new therapeutic targets. Cancer Res. 2012 Jan 01; 72(1):112-21. PMID: 22094876; PMCID: PMC3251639.
    14. Gordan J, Chay WY, Kelley RK, Ko AH, Choo SP, Venook AP. "And what other medications are you taking?". J Clin Oncol. 2011 Apr 10; 29(11):e288-91. PMID: 21245436.
      View in: PubMed
    15. Bertout JA, Majmundar AJ, Gordan J, Lam JC, Ditsworth D, Keith B, Brown EJ, Nathanson KL, Simon MC. HIF2alpha inhibition promotes p53 pathway activity, tumor cell death, and radiation responses. Proc Natl Acad Sci U S A. 2009 Aug 25; 106(34):14391-6. PMID: 19706526; PMCID: PMC2726037.
    16. Wright TM, Brannon AR, Gordan J, Mikels AJ, Mitchell C, Chen S, Espinosa I, van de Rijn M, Pruthi R, Wallen E, Edwards L, Nusse R, Rathmell WK. Ror2, a developmentally regulated kinase, promotes tumor growth potential in renal cell carcinoma. Oncogene. 2009 Jul 09; 28(27):2513-23. PMID: 19448672; PMCID: PMC2771692.
    17. Gordan J, Lal P, Dondeti VR, Letrero R, Parekh KN, Oquendo CE, Greenberg RA, Flaherty KT, Rathmell WK, Keith B, Simon MC, Nathanson KL. HIF-alpha effects on c-Myc distinguish two subtypes of sporadic VHL-deficient clear cell renal carcinoma. Cancer Cell. 2008 Dec 09; 14(6):435-46. PMID: 19061835; PMCID: PMC2621440.
    18. Young RM, Wang SJ, Gordan J, Ji X, Liebhaber SA, Simon MC. Hypoxia-mediated selective mRNA translation by an internal ribosome entry site-independent mechanism. J Biol Chem. 2008 Jun 13; 283(24):16309-19. PMID: 18430730; PMCID: PMC2423241.
    19. Gordan J, Thompson CB, Simon MC. HIF and c-Myc: sibling rivals for control of cancer cell metabolism and proliferation. Cancer Cell. 2007 Aug; 12(2):108-13. PMID: 17692803; PMCID: PMC3215289.
    20. Lum JJ, Bui T, Gruber M, Gordan J, DeBerardinis RJ, Covello KL, Simon MC, Thompson CB. The transcription factor HIF-1alpha plays a critical role in the growth factor-dependent regulation of both aerobic and anaerobic glycolysis. Genes Dev. 2007 May 01; 21(9):1037-49. PMID: 17437992; PMCID: PMC1855230.
    21. Gordan J, Bertout JA, Hu CJ, Diehl JA, Simon MC. HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity. Cancer Cell. 2007 Apr; 11(4):335-47. PMID: 17418410; PMCID: PMC3145406.
    22. Gordan J, Simon MC. Hypoxia-inducible factors: central regulators of the tumor phenotype. Curr Opin Genet Dev. 2007 Feb; 17(1):71-7. PMID: 17208433; PMCID: PMC3215290.
    23. Zhang F, Hamanaka RB, Bobrovnikova-Marjon E, Gordan J, Dai MS, Lu H, Simon MC, Diehl JA. Ribosomal stress couples the unfolded protein response to p53-dependent cell cycle arrest. J Biol Chem. 2006 Oct 06; 281(40):30036-45. PMID: 16893887.
      View in: PubMed
    24. Covello KL, Kehler J, Yu H, Gordan J, Arsham AM, Hu CJ, Labosky PA, Simon MC, Keith B. HIF-2alpha regulates Oct-4: effects of hypoxia on stem cell function, embryonic development, and tumor growth. Genes Dev. 2006 Mar 01; 20(5):557-70. PMID: 16510872; PMCID: PMC1410808.
    25. Wang H, McCann FE, Gordan J, Wu X, Raab M, Malik TH, Davis DM, Rudd CE. ADAP-SLP-76 binding differentially regulates supramolecular activation cluster (SMAC) formation relative to T cell-APC conjugation. J Exp Med. 2004 Oct 18; 200(8):1063-74. PMID: 15477347.
      View in: PubMed
    26. Cullinan SB, Gordan J, Jin J, Harper JW, Diehl JA. The Keap1-BTB protein is an adaptor that bridges Nrf2 to a Cul3-based E3 ligase: oxidative stress sensing by a Cul3-Keap1 ligase. Mol Cell Biol. 2004 Oct; 24(19):8477-86. PMID: 15367669; PMCID: PMC516753.
    27. Gordan J, Vonderheide RH. Universal tumor antigens as targets for immunotherapy. Cytotherapy. 2002; 4(4):317-27. PMID: 12396831.
      View in: PubMed