Angelique Di Domenico, PhD, MSc

Title(s)Assistant Professor, Institute for Neurodegenerative Diseases
SchoolSchool of Medicine
Address675 Nelson Rising Lane, #316
San Francisco CA 94158
ORCID ORCID Icon0000-0002-0592-2560 Additional info
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    University of Barcelona, Barcelona, SpainPhD2017Biomedicine
    King's College London, London, England, UKMSc2012Neuroscience, specialization in neurodegenerative diseases
    Goldsmith's University of London, London, England, UKBSc2010Psychology
    University of California , San Francisco2022Diversity, Equity, and Inclusion Champion Training
    Collapse Awards and Honors
    Barcelona City Council2020The Life Sciences, City of Barcelona Award

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    Angelique received her B.S. in psychology in 2010 and her M.S. in neuroscience with a specialization in neurodegeneration in 2012 at King’s College London, England. She worked under the guidance of Dr. Frank Hirth investigating the effects of TDP-43 on Excitatory Amino Acid Transporter 1 (EAAT1) using a transgenic drosophila model of TDP-43 related ALS. In 2013 she started her Ph.D. work in Biomedicine at the University of Barcelona, Spain and joined Dr. Antonella Consiglio’s laboratory. Her thesis focused on evaluating the glial contributions to Parkinson’s disease (PD) pathogenesis using induced pluripotent stem cells (iPSC). She was awarded her Ph.D. in 2017 and joined the Croft group at NYSCF as a Postdoctoral Fellow in January of 2019 until March 2021. She was focused on investigating the pathogenic mechanisms in PD astrocytes, as well as microglia and their effect on dopaminergic neurons using a combination of 2D and 3D organoid cell culture models, analyzing with non-biased automated analysis softwares (imaris, metamorph, harmony). She is now an Assistant Professor at University California, San Francisco working at the Institute of Neurodegenerative diseases (IND) under the guidance of Nobel laureate Stanley B. Prusiner focused on tau prionopathy.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Blocking IL-6 signaling prevents astrocyte-induced neurodegeneration in an iPSC-based model of Parkinson’s disease. JCI Insights. 2024. Meritxell Pons-Espinal, Lucas Blasco-Agell, Irene Fernandez-Carasa, Pol Andrés-Benito, Angelique di Domenico, Yvonne Richaud-Patin, Valentina Baruffi, Laura Marruecos, Lluís Espinosa, Alicia Garrido, Eduardo Tolosa, Michael J. Edel, Manel Juan Otero, José Luis Mosquera, Isidre Ferrer, Angel Raya, and Antonella Consiglio. View Publication.
    2. CD49f Is a Novel Marker of Functional and Reactive Human iPSC-Derived Astrocytes. Neuron. 2020 08 05; 107(3):436-453.e12. Barbar L, Jain T, Zimmer M, Kruglikov I, Sadick JS, Wang M, Kalpana K, Rose IVL, Burstein SR, Rusielewicz T, Nijsure M, Guttenplan KA, di Domenico A, Croft G, Zhang B, Nobuta H, Hébert JM, Liddelow SA, Fossati V. PMID: 32485136; PMCID: PMC8274549.
      View in: PubMed   Mentions: 71     Fields:    Translation:HumansAnimalsCells
    3. Patient-Specific iPSC-Derived Astrocytes Contribute to Non-Cell-Autonomous Neurodegeneration in Parkinson's Disease. Stem Cell Reports. 2019 02 12; 12(2):213-229. di Domenico A, Carola G, Calatayud C, Pons-Espinal M, Muñoz JP, Richaud-Patin Y, Fernandez-Carasa I, Gut M, Faella A, Parameswaran J, Soriano J, Ferrer I, Tolosa E, Zorzano A, Cuervo AM, Raya A, Consiglio A. PMID: 30639209; PMCID: PMC6372974.
      View in: PubMed   Mentions: 149     Fields:    Translation:HumansCells
    4. iPS Cell Cultures from a Gerstmann-Sträussler-Scheinker Patient with the Y218N PRNP Mutation Recapitulate tau Pathology. Mol Neurobiol. 2018 Apr; 55(4):3033-3048. Matamoros-Angles A, Gayosso LM, Richaud-Patin Y, di Domenico A, Vergara C, Hervera A, Sousa A, Fernández-Borges N, Consiglio A, Gavín R, López de Maturana R, Ferrer I, López de Munain A, Raya Á, Castilla J, Sánchez-Pernaute R, Del Río JA. PMID: 28466265; PMCID: PMC5842509.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    5. Drosophila TDP-43 dysfunction in glia and muscle cells cause cytological and behavioural phenotypes that characterize ALS and FTLD. Hum Mol Genet. 2013 Oct 01; 22(19):3883-93. Diaper DC, Adachi Y, Lazarou L, Greenstein M, Simoes FA, Di Domenico A, Solomon DA, Lowe S, Alsubaie R, Cheng D, Buckley S, Humphrey DM, Shaw CE, Hirth F. PMID: 23727833; PMCID: PMC3766182.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    6. Suppression of the GnRH pulse generator by neurokinin B involves a κ-opioid receptor-dependent mechanism. Endocrinology. 2012 Oct; 153(10):4894-904. Grachev P, Li XF, Kinsey-Jones JS, di Domenico AL, Millar RP, Lightman SL, O'Byrne KT. PMID: 22903614.
      View in: PubMed   Mentions: 47     Fields:    Translation:Animals
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