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Shinya Yamanaka, MD, PhD

Title(s)Professor, Anatomy
SchoolSchool of Medicine
Address1650 Owens St
San Francisco CA 94107
Phone415-355-0960
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoPostdoctoral StudiesGraduate Division
    Collapse Awards and Honors
    2013Breakthrough Prize in Life Sciences
    2012Nobel Prize in Physiology or Medicine
    2012Millennium Technology Award
    2011Wolf Prize in Medicine
    2010March of Dimes Prize in Developmental Biology
    2010Kyoto Prize for Advanced Technology
    2009Lasker Basic Medical Research Award
    2008Shaw Prize in Life Science and Medicine

    Collapse Overview 
    Collapse Overview
    Dr. Shinya Yamanaka is a Senior Investigator and the L.K. Whittier Foundation Investigator in Stem Cell Biology at the Gladstone Institute for Cardiovascular Disease (GICD). Dr. Yamanaka is also a Professor of Anatomy at the University of California, San Francisco, as well as the Director of the Center for iPS Cell Research and Application (CiRA) and a Principal Investigator at the Institute for Integrated Cell-Material Sciences, both at Kyoto University.

    Dr. Yamanaka’s research focuses on ways to generate cells resembling embryonic stem cells by reprogramming somatic, or skin, cells. He seeks to understand the molecular mechanisms that underlie pluripotency and the rapid proliferation of embryonic stem cells—they can become any type of cell in the body—and to identify the factors that induce reprogramming.

    Dr. Yamanaka’s discovery that adult somatic cells can be reprogrammed into pluripotent cells has had a profound effect on developmental and stem cell biology. By introducing the genes for four factors that turn genes on and off, he induced the skin cells of adult mice to become like embryonic stem cells, which he called induced pluripotent stem (iPS) cells. This iPS cell technology represents an entirely new platform for fundamental studies of developmental biology. Rather than using disease models made in yeast, flies, mice or other animals, iPS cells can be taken from patients with a specific disease. As a result, they contain a complete set of the genes that resulted in that disease—representing the potential of an almost perfect disease model for studying disease development, new drugs and treatments.

    In 1996, Dr. Yamanaka became an Assistant Professor at Osaka City University Medical School. In 1999, he was appointed Associate Professor at Nara Institute of Science and Technology, where he became a full professor in 2003. He took his current position as a professor at Kyoto University in 2004 and was appointed as a Senior Investigator at the Gladstone Institutes in 2007. Since 2008, he has directed CiRA.

    Dr. Yamanaka has received many awards and honors, including the Albert Lasker Basic Medical Research Award, the Wolf Prize in Medicine, the Millennium Technology Award, the Shaw Prize, the Kyoto Prize for Advanced Technology, the Gairdner International Award, the Robert Koch Award and the March of Dimes Prize.

    Dr. Yamanaka earned an MD from Kobe University in 1987 and a PhD from Osaka City University in 1993. From 1987 to 1989, he was a resident at the National Osaka Hospital. From 1993 to 1996, he was a postdoctoral fellow at GICD.

    Collapse Research 
    Collapse Research Activities and Funding
    Induced Pluripotent Stem Cells in the Understanding and Treatment of Heart Diseas
    NIH/NHLBI U01HL100406Sep 30, 2009 - Jun 30, 2016
    Role: Co-Principal Investigator
    The Epigenetic Landscape of Heart Development
    NIH/NHLBI U01HL098179Sep 30, 2009 - Jul 31, 2015
    Role: Co-Principal Investigator
    Induced pluripotent stem cells in the understanding and treatment of heart diseas
    NIH/NHLBI R03HL096254Dec 1, 2008 - May 31, 2009
    Role: Co-Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
    Collapse Websites
    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Critical Roles of Translation Initiation and RNA Uridylation in Endogenous Retroviral Expression and Neural Differentiation in Pluripotent Stem Cells. Cell Rep. 2020 Jun 02; 31(9):107715. Takahashi K, Jeong D, Wang S, Narita M, Jin X, Iwasaki M, Perli SD, Conklin BR, Yamanaka S. PMID: 32492424.
      View in: PubMed   Mentions:    Fields:    
    2. Base-Resolution Methylome of Retinal Pigment Epithelial Cells Used in the First Trial of Human Induced Pluripotent Stem Cell-Based Autologous Transplantation. Stem Cell Reports. 2019 10 08; 13(4):761-774. Araki H, Miura F, Watanabe A, Morinaga C, Kitaoka F, Kitano Y, Sakai N, Shibata Y, Terada M, Goto S, Yamanaka S, Takahashi M, Ito T. PMID: 31564644.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    3. Induced 2C Expression and Implantation-Competent Blastocyst-like Cysts from Primed Pluripotent Stem Cells. Stem Cell Reports. 2019 09 10; 13(3):485-498. Kime C, Kiyonari H, Ohtsuka S, Kohbayashi E, Asahi M, Yamanaka S, Takahashi M, Tomoda K. PMID: 31402336.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    4. Generation of a human induced pluripotent stem cell line, BRCi001-A, derived from a patient with mucopolysaccharidosis type I. Stem Cell Res. 2019 04; 36:101406. Suga M, Kondo T, Imamura K, Shibukawa R, Okanishi Y, Sagara Y, Tsukita K, Enami T, Furujo M, Saijo K, Nakamura Y, Osawa M, Saito MK, Yamanaka S, Inoue H. PMID: 30849633.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    5. Application of induced pluripotent stem cells to primary immunodeficiency diseases. Exp Hematol. 2019 03; 71:43-50. Karagiannis P, Yamanaka S, Saito MK. PMID: 30664903.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    6. Induced Pluripotent Stem Cells and Their Use in Human Models of Disease and Development. Physiol Rev. 2019 01 01; 99(1):79-114. Karagiannis P, Takahashi K, Saito M, Yoshida Y, Okita K, Watanabe A, Inoue H, Yamashita JK, Todani M, Nakagawa M, Osawa M, Yashiro Y, Yamanaka S, Osafune K. PMID: 30328784.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    7. Concise Review: Laying the Groundwork for a First-In-Human Study of an Induced Pluripotent Stem Cell-Based Intervention for Spinal Cord Injury. Stem Cells. 2019 01; 37(1):6-13. Tsuji O, Sugai K, Yamaguchi R, Tashiro S, Nagoshi N, Kohyama J, Iida T, Ohkubo T, Itakura G, Isoda M, Shinozaki M, Fujiyoshi K, Kanemura Y, Yamanaka S, Nakamura M, Okano H. PMID: 30371964.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    8. MYC Releases Early Reprogrammed Human Cells from Proliferation Pause via Retinoblastoma Protein Inhibition. Cell Rep. 2018 Apr 10; 23(2):361-375. Rand TA, Sutou K, Tanabe K, Jeong D, Nomura M, Kitaoka F, Tomoda E, Narita M, Nakamura M, Nakamura M, Watanabe A, Rulifson E, Yamanaka S, Takahashi K. PMID: 29641997.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    9. Structural and spatial chromatin features at developmental gene loci in human pluripotent stem cells. Nat Commun. 2017 11 20; 8(1):1616. Ikeda H, Sone M, Yamanaka S, Yamamoto T. PMID: 29158493.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    10. Epigenetic foundations of pluripotent stem cells that recapitulate in vivo pluripotency. Lab Invest. 2017 10; 97(10):1133-1141. Yagi M, Yamanaka S, Yamada Y. PMID: 28869587.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    11. MHC matching improves engraftment of iPSC-derived neurons in non-human primates. Nat Commun. 2017 08 30; 8(1):385. Morizane A, Kikuchi T, Hayashi T, Mizuma H, Takara S, Doi H, Mawatari A, Glasser MF, Shiina T, Ishigaki H, Itoh Y, Okita K, Yamasaki E, Doi D, Onoe H, Ogasawara K, Yamanaka S, Takahashi J. PMID: 28855509.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    12. Enhanced Therapeutic Effects of Human iPS Cell Derived-Cardiomyocyte by Combined Cell-Sheets with Omental Flap Technique in Porcine Ischemic Cardiomyopathy Model. Sci Rep. 2017 08 18; 7(1):8824. Kawamura M, Miyagawa S, Fukushima S, Saito A, Miki K, Funakoshi S, Yoshida Y, Yamanaka S, Shimizu T, Okano T, Daimon T, Toda K, Sawa Y. PMID: 28821761.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    13. Induced Pluripotent Stem Cells 10 Years Later: For Cardiac Applications. Circ Res. 2017 Jun 09; 120(12):1958-1968. Yoshida Y, Yamanaka S. PMID: 28596174.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    14. The Src/c-Abl pathway is a potential therapeutic target in amyotrophic lateral sclerosis. Sci Transl Med. 2017 05 24; 9(391). Imamura K, Izumi Y, Watanabe A, Tsukita K, Woltjen K, Yamamoto T, Hotta A, Kondo T, Kitaoka S, Ohta A, Tanaka A, Watanabe D, Morita M, Takuma H, Tamaoka A, Kunath T, Wray S, Furuya H, Era T, Makioka K, Okamoto K, Fujisawa T, Nishitoh H, Homma K, Ichijo H, Julien JP, Obata N, Hosokawa M, Akiyama H, Kaneko S, Ayaki T, Ito H, Kaji R, Takahashi R, Yamanaka S, Inoue H. PMID: 28539470.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    15. Hybrid Cellular Metabolism Coordinated by Zic3 and Esrrb Synergistically Enhances Induction of Naive Pluripotency. Cell Metab. 2017 May 02; 25(5):1103-1117.e6. Sone M, Morone N, Nakamura T, Tanaka A, Okita K, Woltjen K, Nakagawa M, Heuser JE, Yamada Y, Yamanaka S, Yamamoto T. PMID: 28467928.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    16. New Models for Therapeutic Innovation from Japan. EBioMedicine. 2017 04; 18:3-4. Karagiannis P, Onodera A, Yamanaka S. PMID: 28377227.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    17. Autologous Induced Stem-Cell-Derived Retinal Cells for Macular Degeneration. N Engl J Med. 2017 03 16; 376(11):1038-1046. Mandai M, Watanabe A, Kurimoto Y, Hirami Y, Morinaga C, Daimon T, Fujihara M, Akimaru H, Sakai N, Shibata Y, Terada M, Nomiya Y, Tanishima S, Nakamura M, Kamao H, Sugita S, Onishi A, Ito T, Fujita K, Kawamata S, Go MJ, Shinohara C, Hata KI, Sawada M, Yamamoto M, Ohta S, Ohara Y, Yoshida K, Kuwahara J, Kitano Y, Amano N, Umekage M, Kitaoka F, Tanaka A, Okada C, Takasu N, Ogawa S, Yamanaka S, Takahashi M. PMID: 28296613.
      View in: PubMed   Mentions: 150     Fields:    Translation:HumansCells
    18. Nat1 promotes translation of specific proteins that induce differentiation of mouse embryonic stem cells. Proc Natl Acad Sci U S A. 2017 01 10; 114(2):340-345. Sugiyama H, Takahashi K, Yamamoto T, Iwasaki M, Narita M, Nakamura M, Rand TA, Nakagawa M, Watanabe A, Yamanaka S. PMID: 28003464.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    19. Induced pluripotent stem cell technology: a decade of progress. Nat Rev Drug Discov. 2017 02; 16(2):115-130. Shi Y, Inoue H, Wu JC, Yamanaka S. PMID: 27980341.
      View in: PubMed   Mentions: 128     Fields:    Translation:HumansCells
    20. BMP-SMAD-ID promotes reprogramming to pluripotency by inhibiting p16/INK4A-dependent senescence. Proc Natl Acad Sci U S A. 2016 11 15; 113(46):13057-13062. Hayashi Y, Hsiao EC, Sami S, Lancero M, Schlieve CR, Nguyen T, Yano K, Nagahashi A, Ikeya M, Matsumoto Y, Nishimura K, Fukuda A, Hisatake K, Tomoda K, Asaka I, Toguchida J, Conklin BR, Yamanaka S. PMID: 27794120.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    21. Patient-Specific Human Induced Pluripotent Stem Cell Model Assessed with Electrical Pacing Validates S107 as a Potential Therapeutic Agent for Catecholaminergic Polymorphic Ventricular Tachycardia. PLoS One. 2016; 11(10):e0164795. Sasaki K, Makiyama T, Yoshida Y, Wuriyanghai Y, Kamakura T, Nishiuchi S, Hayano M, Harita T, Yamamoto Y, Kohjitani H, Hirose S, Chen J, Kawamura M, Ohno S, Itoh H, Takeuchi A, Matsuoka S, Miura M, Sumitomo N, Horie M, Yamanaka S, Kimura T. PMID: 27764147.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    22. Autotaxin-mediated lipid signaling intersects with LIF and BMP signaling to promote the naive pluripotency transcription factor program. Proc Natl Acad Sci U S A. 2016 11 01; 113(44):12478-12483. Kime C, Sakaki-Yumoto M, Goodrich L, Hayashi Y, Sami S, Derynck R, Asahi M, Panning B, Yamanaka S, Tomoda K. PMID: 27738243.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    23. MicroRNA-302 switch to identify and eliminate undifferentiated human pluripotent stem cells. Sci Rep. 2016 09 09; 6:32532. Parr CJ, Katayama S, Miki K, Kuang Y, Yoshida Y, Morizane A, Takahashi J, Yamanaka S, Saito H. PMID: 27608814.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    24. Epigenetic Variation between Human Induced Pluripotent Stem Cell Lines Is an Indicator of Differentiation Capacity. Cell Stem Cell. 2016 09 01; 19(3):341-54. Nishizawa M, Chonabayashi K, Nomura M, Tanaka A, Nakamura M, Inagaki A, Nishikawa M, Takei I, Oishi A, Tanabe K, Ohnuki M, Yokota H, Koyanagi-Aoi M, Okita K, Watanabe A, Takaori-Kondo A, Yamanaka S, Yoshida Y. PMID: 27476965.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    25. Identification of MMP1 as a novel risk factor for intracranial aneurysms in ADPKD using iPSC models. Sci Rep. 2016 07 15; 6:30013. Ameku T, Taura D, Sone M, Numata T, Nakamura M, Shiota F, Toyoda T, Matsui S, Araoka T, Yasuno T, Mae S, Kobayashi H, Kondo N, Kitaoka F, Amano N, Arai S, Ichisaka T, Matsuura N, Inoue S, Yamamoto T, Takahashi K, Asaka I, Yamada Y, Ubara Y, Muso E, Fukatsu A, Watanabe A, Sato Y, Nakahata T, Mori Y, Koizumi A, Nakao K, Yamanaka S, Osafune K. PMID: 27418197.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    26. Screening of Human cDNA Library Reveals Two differentiation-Related Genes, HHEX and HLX, as Promoters of Early Phase Reprogramming toward Pluripotency. Stem Cells. 2016 11; 34(11):2661-2669. Yamakawa T, Sato Y, Matsumura Y, Kobayashi Y, Kawamura Y, Goshima N, Yamanaka S, Okita K. PMID: 27335261.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    27. Establishment of Human Neural Progenitor Cells from Human Induced Pluripotent Stem Cells with Diverse Tissue Origins. Stem Cells Int. 2016; 2016:7235757. Fukusumi H, Shofuda T, Bamba Y, Yamamoto A, Kanematsu D, Handa Y, Okita K, Nakamura M, Yamanaka S, Okano H, Kanemura Y. PMID: 27212953.
      View in: PubMed   Mentions:
    28. When Myc's asleep, embryonic stem cells are dormant. EMBO J. 2016 Apr 15; 35(8):801-2. Nakagawa M, Karagiannis P, Yamanaka S. PMID: 26968984.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    29. SOX2 O-GlcNAcylation alters its protein-protein interactions and genomic occupancy to modulate gene expression in pluripotent cells. Elife. 2016 Mar 07; 5:e10647. Myers SA, Peddada S, Chatterjee N, Friedrich T, Tomoda K, Krings G, Thomas S, Maynard J, Broeker M, Thomson M, Pollard K, Yamanaka S, Burlingame AL, Panning B. PMID: 26949256.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    30. Recent policies that support clinical application of induced pluripotent stem cell-based regenerative therapies. Regen Ther. 2016 Jun; 4:36-47. Azuma K, Yamanaka S. PMID: 31245486.
      View in: PubMed   Mentions:
    31. A decade of transcription factor-mediated reprogramming to pluripotency. Nat Rev Mol Cell Biol. 2016 Mar; 17(3):183-93. Takahashi K, Yamanaka S. PMID: 26883003.
      View in: PubMed   Mentions: 127     Fields:    Translation:HumansAnimals
    32. Enhanced engraftment, proliferation, and therapeutic potential in heart using optimized human iPSC-derived cardiomyocytes. Sci Rep. 2016 Jan 08; 6:19111. Funakoshi S, Miki K, Takaki T, Okubo C, Hatani T, Chonabayashi K, Nishikawa M, Takei I, Oishi A, Narita M, Hoshijima M, Kimura T, Yamanaka S, Yoshida Y. PMID: 26743035.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    33. Inducible Transgene Expression in Human iPS Cells Using Versatile All-in-One piggyBac Transposons. Methods Mol Biol. 2016; 1357:111-31. Kim SI, Oceguera-Yanez F, Sakurai C, Nakagawa M, Yamanaka S, Woltjen K. PMID: 26025620.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    34. Efficient CRISPR/Cas9-Based Genome Engineering in Human Pluripotent Stem Cells. Curr Protoc Hum Genet. 2016 Jan 01; 88:21.4.1-21.4.23. Kime C, Mandegar MA, Srivastava D, Yamanaka S, Conklin BR, Rand TA. PMID: 26724721.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    35. A study on ensuring the quality and safety of pharmaceuticals and medical devices derived from processing of allogeneic human induced pluripotent stem(-Like) cells. Regen Ther. 2015 Dec; 2:95-108. Hayakawa T, Aoi T, Umezawa A, Ozawa K, Sato Y, Sawa Y, Matsuyama A, Yamanaka S, Yamato M. PMID: 31245463.
      View in: PubMed   Mentions:
    36. A study on ensuring the quality and safety of pharmaceuticals and medical devices derived from the processing of autologous human somatic stem cells. Regen Ther. 2015 Dec; 2:57-69. Hayakawa T, Aoi T, Umezawa A, Ozawa K, Sato Y, Sawa Y, Matsuyama A, Yamanaka S, Yamato M. PMID: 31245460.
      View in: PubMed   Mentions:
    37. A study on ensuring the quality and safety of pharmaceuticals and medical devices derived from processing of autologous human induced pluripotent stem(-like) cells. Regen Ther. 2015 Dec; 2:81-94. Hayakawa T, Aoi T, Umezawa A, Ozawa K, Sato Y, Sawa Y, Matsuyama A, Yamanaka S, Yamato M. PMID: 31245462.
      View in: PubMed   Mentions:
    38. Practical Integration-Free Episomal Methods for Generating Human Induced Pluripotent Stem Cells. Curr Protoc Hum Genet. 2015 Oct 06; 87:21.2.1-21.2.21. Kime C, Rand TA, Ivey KN, Srivastava D, Yamanaka S, Tomoda K. PMID: 26439714.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    39. A developmental framework for induced pluripotency. Development. 2015 Oct 01; 142(19):3274-85. Takahashi K, Yamanaka S. PMID: 26443632.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    40. From Genomics to Gene Therapy: Induced Pluripotent Stem Cells Meet Genome Editing. Annu Rev Genet. 2015; 49:47-70. Hotta A, Yamanaka S. PMID: 26407033.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    41. Cell Therapy Using Human Induced Pluripotent Stem Cell-Derived Renal Progenitors Ameliorates Acute Kidney Injury in Mice. Stem Cells Transl Med. 2015 Sep; 4(9):980-92. Toyohara T, Mae S, Sueta S, Inoue T, Yamagishi Y, Kawamoto T, Kasahara T, Hoshina A, Toyoda T, Tanaka H, Araoka T, Sato-Otsubo A, Takahashi K, Sato Y, Yamaji N, Ogawa S, Yamanaka S, Osafune K. PMID: 26198166.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    42. Robust In Vitro Induction of Human Germ Cell Fate from Pluripotent Stem Cells. Cell Stem Cell. 2015 Aug 06; 17(2):178-94. Sasaki K, Yokobayashi S, Nakamura T, Okamoto I, Yabuta Y, Kurimoto K, Ohta H, Moritoki Y, Iwatani C, Tsuchiya H, Nakamura S, Sekiguchi K, Sakuma T, Yamamoto T, Mori T, Woltjen K, Nakagawa M, Yamamoto T, Takahashi K, Yamanaka S, Saitou M. PMID: 26189426.
      View in: PubMed   Mentions: 68     Fields:    Translation:HumansAnimalsCells
    43. Efficient Detection and Purification of Cell Populations Using Synthetic MicroRNA Switches. Cell Stem Cell. 2015 Jun 04; 16(6):699-711. Miki K, Endo K, Takahashi S, Funakoshi S, Takei I, Katayama S, Toyoda T, Kotaka M, Takaki T, Umeda M, Okubo C, Nishikawa M, Oishi A, Narita M, Miyashita I, Asano K, Hayashi K, Osafune K, Yamanaka S, Saito H, Yoshida Y. PMID: 26004781.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    44. Direct cardiac reprogramming: progress and challenges in basic biology and clinical applications. Circ Res. 2015 Apr 10; 116(8):1378-91. Sadahiro T, Yamanaka S, Ieda M. PMID: 25858064.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    45. Structure-based discovery of NANOG variant with enhanced properties to promote self-renewal and reprogramming of pluripotent stem cells. Proc Natl Acad Sci U S A. 2015 Apr 14; 112(15):4666-71. Hayashi Y, Caboni L, Das D, Yumoto F, Clayton T, Deller MC, Nguyen P, Farr CL, Chiu HJ, Miller MD, Elsliger MA, Deacon AM, Godzik A, Lesley SA, Tomoda K, Conklin BR, Wilson IA, Yamanaka S, Fletterick RJ. PMID: 25825768.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    46. KLF4 N-terminal variance modulates induced reprogramming to pluripotency. Stem Cell Reports. 2015 Apr 14; 4(4):727-43. Kim SI, Oceguera-Yanez F, Hirohata R, Linker S, Okita K, Yamada Y, Yamamoto T, Yamanaka S, Woltjen K. PMID: 25772473.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    47. Development of a global network of induced pluripotent stem cell haplobanks. Regen Med. 2015; 10(3):235-8. Wilmut I, Leslie S, Martin NG, Peschanski M, Rao M, Trounson A, Turner D, Turner ML, Yamanaka S, Taylor CJ. PMID: 25933231.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    48. The homeobox gene DLX4 promotes generation of human induced pluripotent stem cells. Sci Rep. 2014 Dec 04; 4:7283. Tamaoki N, Takahashi K, Aoki H, Iida K, Kawaguchi T, Hatakeyama D, Inden M, Chosa N, Ishisaki A, Kunisada T, Shibata T, Goshima N, Yamanaka S, Tezuka K. PMID: 25471527.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    49. Precise correction of the dystrophin gene in duchenne muscular dystrophy patient induced pluripotent stem cells by TALEN and CRISPR-Cas9. Stem Cell Reports. 2015 Jan 13; 4(1):143-154. Li HL, Fujimoto N, Sasakawa N, Shirai S, Ohkame T, Sakuma T, Tanaka M, Amano N, Watanabe A, Sakurai H, Yamamoto T, Yamanaka S, Hotta A. PMID: 25434822.
      View in: PubMed   Mentions: 136     Fields:    Translation:HumansCells
    50. Computational image analysis of colony and nuclear morphology to evaluate human induced pluripotent stem cells. Sci Rep. 2014 Nov 11; 4:6996. Tokunaga K, Saitoh N, Goldberg IG, Sakamoto C, Yasuda Y, Yoshida Y, Yamanaka S, Nakao M. PMID: 25385348.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    51. The fate of cell reprogramming. Nat Methods. 2014 Oct; 11(10):1006-8. Karagiannis P, Yamanaka S. PMID: 25264776.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    52. Dynamic regulation of human endogenous retroviruses mediates factor-induced reprogramming and differentiation potential. Proc Natl Acad Sci U S A. 2014 Aug 26; 111(34):12426-31. Ohnuki M, Tanabe K, Sutou K, Teramoto I, Sawamura Y, Narita M, Nakamura M, Tokunaga Y, Nakamura M, Watanabe A, Yamanaka S, Takahashi K. PMID: 25097266.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansCells
    53. Harmonizing standards for producing clinical-grade therapies from pluripotent stem cells. Nat Biotechnol. 2014 Aug; 32(8):724-6. Andrews PW, Cavagnaro J, Cavanagro J, Deans R, Feigal E, Feigel E, Horowitz E, Keating A, Rao M, Turner M, Wilmut I, Yamanaka S. PMID: 25093882.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    54. Calcium transients closely reflect prolonged action potentials in iPSC models of inherited cardiac arrhythmia. Stem Cell Reports. 2014 Aug 12; 3(2):269-81. Spencer CI, Baba S, Nakamura K, Hua EA, Sears MA, Fu CC, Zhang J, Balijepalli S, Tomoda K, Hayashi Y, Lizarraga P, Wojciak J, Scheinman MM, Aalto-Setälä K, Makielski JC, January CT, Healy KE, Kamp TJ, Yamanaka S, Conklin BR. PMID: 25254341.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
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