Charles Hart, PhD
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Title(s) | Director Catalyst Program, Innovation Ventures |
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School | Chancellor/EVC/FAS |
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Address | 600 16th St San Francisco CA 94158
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Phone | 415-514-8510 |
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vCard | Download vCard |
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ORNG Applications Bibliographic
Altmetrics Details
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media.
(Note that publications are often cited in additional ways that are not shown here.)
Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication.
Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication.
Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.)
Click a Field or Translation tag to filter the publications.
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Functional CRISPR and shRNA Screens Identify Involvement of Mitochondrial Electron Transport in the Activation of Evofosfamide. Mol Pharmacol. 2019 06; 95(6):638-651.
Hunter FW, Devaux JBL, Meng F, Hong CR, Khan A, Tsai P, Ketela TW, Sharma I, Kakadia PM, Marastoni S, Shalev Z, Hickey AJR, Print CG, Bohlander SK, Hart CP, Wouters BG, Wilson WR. PMID: 30979813.
View in: PubMed Mentions: Fields: Translation: HumansCells
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Evofosfamide for the treatment of human papillomavirus-negative head and neck squamous cell carcinoma. JCI Insight. 2018 08 23; 3(16).
Jamieson SM, Tsai P, Kondratyev MK, Budhani P, Liu A, Senzer NN, Chiorean EG, Jalal SI, Nemunaitis JJ, Kee D, Shome A, Wong WW, Li D, Poonawala-Lohani N, Kakadia PM, Knowlton NS, Lynch CR, Hong CR, Lee TW, Grénman RA, Caporiccio L, McKee TD, Zaidi M, Butt S, Macann AM, McIvor NP, Chaplin JM, Hicks KO, Bohlander SK, Wouters BG, Hart CP, Print CG, Wilson WR, Curran MA, Hunter FW. PMID: 30135316.
View in: PubMed Mentions: 5 Fields: Translation: HumansCellsCTClinical Trials
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Hypoxia-activated evofosfamide for treatment of recurrent bevacizumab-refractory glioblastoma: a phase I surgical study. Neuro Oncol. 2018 08 02; 20(9):1231-1239.
Brenner A, Zuniga R, Sun JD, Floyd J, Hart CP, Kroll S, Fichtel L, Cavazos D, Caflisch L, Gruslova A, Huang S, Liu Y, Lodi A, Tiziani S. PMID: 29415215.
View in: PubMed Mentions: 3 Fields: Translation: HumansCTClinical Trials
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Metabolic and Physiologic Imaging Biomarkers of the Tumor Microenvironment Predict Treatment Outcome with Radiation or a Hypoxia-Activated Prodrug in Mice. Cancer Res. 2018 07 15; 78(14):3783-3792.
Matsumoto S, Kishimoto S, Saito K, Takakusagi Y, Munasinghe JP, Devasahayam N, Hart CP, Gillies RJ, Mitchell JB, Krishna MC. PMID: 29792309.
View in: PubMed Mentions: 2 Fields: Translation: HumansAnimalsCells
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Radiotherapy Synergizes with the Hypoxia-Activated Prodrug Evofosfamide: In Vitro and In Vivo Studies. Antioxid Redox Signal. 2018 Jan 10; 28(2):131-140.
Takakusagi Y, Kishimoto S, Naz S, Matsumoto S, Saito K, Hart CP, Mitchell JB, Krishna MC. PMID: 28741367.
View in: PubMed Mentions: 4 Fields: Translation: HumansAnimalsCells
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A Combination of Radiation and the Hypoxia-Activated Prodrug Evofosfamide (TH-302) is Efficacious against a Human Orthotopic Pancreatic Tumor Model. Transl Oncol. 2017 Oct; 10(5):760-765.
Hajj C, Russell J, Hart CP, Goodman KA, Lowery MA, Haimovitz-Friedman A, Deasy JO, Humm JL. PMID: 28778024.
View in: PubMed Mentions:
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Hypoxia Imaging With PET Correlates With Antitumor Activity of the Hypoxia-Activated Prodrug Evofosfamide (TH-302) in Rodent Glioma Models. Tomography. 2016 Sep; 2(3):229-237.
Stokes AM, Hart CP, Quarles CC. PMID: 27752544.
View in: PubMed Mentions: 7 Fields:
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Preclinical Benefit of Hypoxia-Activated Intra-arterial Therapy with Evofosfamide in Liver Cancer. Clin Cancer Res. 2017 Jan 15; 23(2):536-548.
Duran R, Mirpour S, Pekurovsky V, Ganapathy-Kanniappan S, Brayton CF, Cornish TC, Gorodetski B, Reyes J, Chapiro J, Schernthaner RE, Frangakis C, Lin M, Sun JD, Hart CP, Geschwind JF. PMID: 27440271.
View in: PubMed Mentions: 5 Fields: Translation: HumansAnimals
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Multimodal targeting of tumor vasculature and cancer stem-like cells in sarcomas with VEGF-A inhibition, HIF-1a inhibition, and hypoxia-activated chemotherapy. Oncotarget. 2016 Jul 12; 7(28):42844-42858.
Yoon C, Chang KK, Lee JH, Tap WD, Hart CP, Simon MC, Yoon SS. PMID: 27374091.
View in: PubMed Mentions: 4 Fields: Translation: HumansAnimalsCells
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MR Imaging Biomarkers to Monitor Early Response to Hypoxia-Activated Prodrug TH-302 in Pancreatic Cancer Xenografts. PLoS One. 2016; 11(5):e0155289.
Zhang X, Wojtkowiak JW, Martinez GV, Cornnell HH, Hart CP, Baker AF, Gillies R. PMID: 27227903.
View in: PubMed Mentions: 8 Fields: Translation: HumansAnimalsCells
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Comparison of hypoxia-activated prodrug evofosfamide (TH-302) and ifosfamide in preclinical non-small cell lung cancer models. . 2016 04 02; 17(4):371-80.
Sun JD, Liu Q, Ahluwalia D, Ferraro DJ, Wang Y, Jung D, Matteucci MD, Hart CP. PMID: 26818215.
View in: PubMed Mentions:
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Hypoxia-Activated Prodrug TH-302 Targets Hypoxic Bone Marrow Niches in Preclinical Leukemia Models. Clin Cancer Res. 2016 Apr 01; 22(7):1687-98.
Benito J, Ramirez MS, Millward NZ, Velez J, Harutyunyan KG, Lu H, Shi YX, Matre P, Jacamo R, Ma H, Konoplev S, McQueen T, Volgin A, Protopopova M, Mu H, Lee J, Bhattacharya PK, Marszalek JR, Davis RE, Bankson JA, Cortes JE, Hart CP, Andreeff M, Konopleva M. PMID: 26603259.
View in: PubMed Mentions: 19 Fields: Translation: HumansAnimalsCells
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Combination treatment with hypoxia-activated prodrug evofosfamide (TH-302) and mTOR inhibitors results in enhanced antitumor efficacy in preclinical renal cell carcinoma models. Am J Cancer Res. 2015; 5(7):2139-55.
Sun JD, Ahluwalia D, Liu Q, Li W, Wang Y, Meng F, Bhupathi D, Matteucci MD, Hart CP. PMID: 26328245.
View in: PubMed Mentions:
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Enhancement of hypoxia-activated prodrug TH-302 anti-tumor activity by Chk1 inhibition. BMC Cancer. 2015 May 21; 15:422.
Meng F, Bhupathi D, Sun JD, Liu Q, Ahluwalia D, Wang Y, Matteucci MD, Hart CP. PMID: 25994202.
View in: PubMed Mentions: 5 Fields: Translation: HumansAnimalsCells
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TH-302 in Combination with Radiotherapy Enhances the Therapeutic Outcome and Is Associated with Pretreatment [18F]HX4 Hypoxia PET Imaging. Clin Cancer Res. 2015 Jul 01; 21(13):2984-92.
Peeters SG, Zegers CM, Biemans R, Lieuwes NG, van Stiphout RG, Yaromina A, Sun JD, Hart CP, Windhorst AD, van Elmpt W, Dubois LJ, Lambin P. PMID: 25805800.
View in: PubMed Mentions: 27 Fields: Translation: Animals
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Efficacy and safety of the hypoxia-activated prodrug TH-302 in combination with gemcitabine and nab-paclitaxel in human tumor xenograft models of pancreatic cancer. . 2015; 16(3):438-49.
Sun JD, Liu Q, Ahluwalia D, Li W, Meng F, Wang Y, Bhupathi D, Ruprell AS, Hart CP. PMID: 25679067.
View in: PubMed Mentions:
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Evaluation of the "steal" phenomenon on the efficacy of hypoxia activated prodrug TH-302 in pancreatic cancer. PLoS One. 2014; 9(12):e113586.
Bailey KM, Cornnell HH, Ibrahim-Hashim A, Wojtkowiak JW, Hart CP, Zhang X, Leos R, Martinez GV, Baker AF, Gillies RJ. PMID: 25532146.
View in: PubMed Mentions: 4 Fields: Translation: HumansAnimalsCells
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Pyruvate induces transient tumor hypoxia by enhancing mitochondrial oxygen consumption and potentiates the anti-tumor effect of a hypoxia-activated prodrug TH-302. PLoS One. 2014; 9(9):e107995.
PMID: 25254649.
View in: PubMed Mentions: 9 Fields: Translation: HumansAnimalsCells
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Activity of the hypoxia-activated prodrug, TH-302, in preclinical human acute myeloid leukemia models. Clin Cancer Res. 2013 Dec 01; 19(23):6506-19.
PMID: 24088735.
View in: PubMed Mentions: 18 Fields: Translation: HumansAnimalsCells
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Synergistic induction of apoptosis in multiple myeloma cells by bortezomib and hypoxia-activated prodrug TH-302, in vivo and in vitro. . 2013 Sep; 12(9):1763-73.
PMID: 23832122.
View in: PubMed Mentions:
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Hypoxia promotes dissemination of multiple myeloma through acquisition of epithelial to mesenchymal transition-like features. Blood. 2012 Jun 14; 119(24):5782-94.
PMID: 22394600.
View in: PubMed Mentions: 110 Fields: Translation: HumansAnimalsCells
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TH-302, a hypoxia-activated prodrug with broad in vivo preclinical combination therapy efficacy: optimization of dosing regimens and schedules. Cancer Chemother Pharmacol. 2012 Jun; 69(6):1487-98.
PMID: 22382881.
View in: PubMed Mentions: 41 Fields: Translation: HumansAnimalsCells
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Selective tumor hypoxia targeting by hypoxia-activated prodrug TH-302 inhibits tumor growth in preclinical models of cancer. Clin Cancer Res. 2012 Feb 01; 18(3):758-70.
PMID: 22184053.
View in: PubMed Mentions: 64 Fields: Translation: HumansAnimalsCells
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Molecular and cellular pharmacology of the hypoxia-activated prodrug TH-302. . 2012 Mar; 11(3):740-51.
PMID: 22147748.
View in: PubMed Mentions:
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14-Aminocamptothecins: their synthesis, preclinical activity, and potential use for cancer treatment. J Med Chem. 2011 Mar 24; 54(6):1715-23.
Duan JX, Cai X, Meng F, Sun JD, Liu Q, Jung D, Jiao H, Matteucci J, Jung B, Bhupathi D, Ahluwalia D, Huang H, Hart CP, Matteucci M. PMID: 21341674.
View in: PubMed Mentions: 4 Fields: Translation: HumansAnimalsCells
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Targeting the multiple myeloma hypoxic niche with TH-302, a hypoxia-activated prodrug. Blood. 2010 Sep 02; 116(9):1524-7.
Hu J, Handisides DR, Van Valckenborgh E, De Raeve H, Menu E, Vande Broek I, Liu Q, Sun JD, Van Camp B, Hart CP, Vanderkerken K. PMID: 20530289.
View in: PubMed Mentions: 59 Fields: Translation: HumansAnimalsCells
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Geochemistry of inorganic nitrogen in waters released from coal-bed natural gas production wells in the Powder River Basin, Wyoming. Environ Sci Technol. 2009 Apr 01; 43(7):2348-54.
Smith RL, Repert DA, Hart CP. PMID: 19452885.
View in: PubMed Mentions: Fields:
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Potent and highly selective hypoxia-activated achiral phosphoramidate mustards as anticancer drugs. J Med Chem. 2008 Apr 24; 51(8):2412-20.
Duan JX, Jiao H, Kaizerman J, Stanton T, Evans JW, Lan L, Lorente G, Banica M, Jung D, Wang J, Ma H, Li X, Yang Z, Hoffman RM, Ammons WS, Hart CP, Matteucci M. PMID: 18257544.
View in: PubMed Mentions: 60 Fields: Translation: HumansAnimalsCells
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A novel class of tubulin inhibitors that exhibit potent antiproliferation and in vitro vessel-disrupting activity. Cancer Chemother Pharmacol. 2008 May; 61(6):953-63.
Meng F, Cai X, Duan J, Matteucci MG, Hart CP. PMID: 17639393.
View in: PubMed Mentions: 7 Fields: Translation: HumansCells
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ARC-111 inhibits hypoxia-mediated hypoxia-inducible factor-1alpha accumulation. Anticancer Drugs. 2007 Apr; 18(4):435-45.
Meng F, Nguyen XT, Cai X, Duan J, Matteucci M, Hart CP. PMID: 17351396.
View in: PubMed Mentions: 1 Fields: Translation: HumansCells
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Finding the target after screening the phenotype. Drug Discov Today. 2005 Apr 01; 10(7):513-9.
Hart CP. PMID: 15809197.
View in: PubMed Mentions: 23 Fields: Translation: HumansAnimals
This graph shows the total number of publications by year. To see the data as text, click here.
This graph shows the total number of publications by year. To return to the graph, click here.
Year | Publications |
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2005 | 1 | 2007 | 2 | 2008 | 1 | 2009 | 1 | 2010 | 1 | 2011 | 3 | 2012 | 2 | 2013 | 2 | 2014 | 2 | 2015 | 5 | 2016 | 5 | 2017 | 2 | 2018 | 3 | 2019 | 1 |
This graph shows the number and percent of publications by field.
Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications.
Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
To see the data as text, click here.
This graph shows the number and percent of publications by field.
Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications.
Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
To see the data as text, click here.
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