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Jennifer Grandis, MD

Title(s)American Cancer Society Professor, Otolaryngology
SchoolSchool of Medicine
Address550 16th. Street
San Francisco CA 94158
Phone415-502-3470
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    Collapse Biography 
    Collapse Education and Training
    University of Pittsburgh Residency1993School of Medicine, Otolaryngology
    University of PittsburghResearch Fellowship1992School of Medicine, Infections Disease
    University of PittsburghResidency1988School of Medicine, Surgery
    University of PittsburghM.D.1987School of Medicine
    Swarthmore CollegeBA1982Biology
    Swarthmore CollegeBA1982Art History
    Collapse Awards and Honors
    University of Pittsburgh, School of Medicine1987Kenneth H. Hinderer Award in Otolaryngology
    University of Pittsburgh, School of Medicine1987Leo H. Criep, Award in Medicine,
    University of Pittsburgh1986Alpha Omega Alpha
    Swarthmore College1982Oak Leaf Award
    American Society for Clinical Investigation2002Elected Member
    University of Pittsburgh Cancer Institute2003Scientific Leadership Award
    Pittsburgh Magazine2005  - 2014Top Doctor
    American Cancer Society2008  - presAmerican Cancer Society Clinical Research Professorship
    University of Pittsburgh2009Chancellor’s Distinguished Research Award
    MD Anderson Cancer Center2009Waun Ki Hong Visiting Professorship
    University of Pittsburgh School of Medicine2010Philip Hench Distinguished Alumnus Award
    Association of American Physicians2010Elected Member
    University of Pittsburgh2011Provost’s Award for Excellence in Mentoring
    The Ochsner Clinic Foundation2012Alton Oschner Award Relating Smoking and Disease
    Institute of Medicine (IOM) of The National Academies2012Elected Member
    University of Pittsburgh School of Medicine2012Distinguished Professor of Otolaryngology
    University of Pittsburgh and Carnegie Mellon University2014William E. Brown Outstanding MSTP Mentor Award, Medical Scientist Training Program
    2015Peggy Wheelock Award for Excellence in Research, Mentoring, and Promotion of Women in Science

    Collapse Overview 
    Collapse Overview
    Dr. Jennifer R. Grandis received her medical degree from the University of Pittsburgh School of Medicine, Pennsylvania, and completed her internship from the same institution. Dr. Grandis completed both a residency and an Infectious Disease fellowship from the University of Pittsburgh School of Medicine, Pennsylvania. Prior to joining UCSF, Dr. Grandis was the UPMC Endowed Chair in Head and Neck Cancer Surgical Research and Distinguished Professor of Otolaryngology and Pharmacology and Chemical Biology at the University of Pittsburgh. She led the Head and Neck Cancer Program and was the Vice Chair for Research in the Department of Otolaryngology.

    Dr. Grandis’s research focuses on the signal transduction in head and neck squamous cell carcinoma (HNSCC) development and progression with the ultimate goal of targeting key pathways for therapeutic benefit. By taking key findings from the clinic and investigating mechanisms in a series of preclinical models, as well as developing novel therapeutic approaches in the laboratory and carrying out innovative clinical trials that employ these treatment strategies.

    Dr. Grandis is an American Cancer Society Clinical Research Professor, and a member of the American Society for Clinical Investigation, the American Association of Physicians and the Institute of Medicine of the National Academies. She has published over 260 peer-reviewed articles. She has also contributed to more than 50 review articles and book chapters.

    Research:
    Dr. Grandis's is dedicated to increasing our understanding of the genetic and epigenetic alterations in the upper aerodigestive tract mucosa, which mediate head and neck squamous cell carcinoma (HNSCC) progression. The overall goal is to identify predictive biomarkers, which can serve to select patients for therapies, including molecular targeting approaches. Translational resources developed to support projects include a large collection of patient-derived xenografts (PDXs) and tissue microarrays of over 500 human HNSCCs linked to a professionally curated clinical and pathologic database that includes information on treatment and survival. To date, the have examined the role of the epidermal growth factor receptor (EGFR), it’s ligands coordinate activation of STAT3 (signal transducer and activator of transcription) in head and neck carcinogenesis. Cumulative evidence from her laboratory suggests that TGF-?lpha/EGFR autocrine signaling leading to STAT3 activation is as early event in head and neck carcinogenesis. Strategies aimed at blocking the ligand, receptor or signaling protein demonstrated anti-tumor efficacy in preclinical models. Based on these promising results, they completed a Phase I clinical trial to investigate the toxicity and biologic effects of EGFR antisense gene therapy and a Phase II study was recently closed to accrual. They have developed STAT3 targeting strategies using a decoy oligonucleotide approach and early phase clinical testing demonstrated feasibility without toxicity. Ongoing studies are aimed at identifying the targetable genetic alterations in these cancers with the goal of designing precision medicine approaches. Emerging targets include activating mutations of the PI3K signaling pathway, primarily in HNSCC linked to HPV infection and mutation or promoter hypermethylation of selected PTPRs, which lead to STAT3 activation.

    Specialty:
    General Otolaryngology

    Expertise:
    Clinical and translational research

    Professional Interests:
    Head and neck cancer, signal transduction, precision medicine, experimental therapeutics, preclinical cancer models, receptor crosstalk

    Education and Training:
    • Medical School: University of Pittsburgh School of Medicine, Pittsburgh, PA
    • Internship: University of Pittsburgh School of Medicine, Pittsburgh, PA
    • Residency: University of Pittsburgh School of Medicine, Pittsburgh, PA
    • Fellowship: University of Pittsburgh School of Medicine, Pittsburgh, PA – Infectious Disease

    Collapse Research 
    Collapse Research Activities and Funding
    Targeting STAT3 to enhance anti-tumor immunity
    NIH/NIDCR R01DE028289Aug 13, 2019 - May 31, 2024
    Role: Co-Principal Investigator
    Integrating genomics and the protein interactome for HPV+ head and neck cancer therapy
    NIH/NCI R35CA231998Aug 15, 2018 - Jul 31, 2025
    Role: Principal Investigator
    Clinical and Translational Science Institute
    NIH/NCATS UL1TR001872Jul 18, 2016 - May 31, 2021
    Role: Principal Investigator
    PI3K Pathway Mutations in Head and Neck Cancer
    NIH/NIDCR R01DE023685May 1, 2014 - May 31, 2024
    Role: Principal Investigator
    Clinical and Translational Science Institute
    NIH/NCATS UL1TR000004Aug 1, 2012 - Jun 30, 2016
    Role: Principal Investigator
    Research Workshop on the Biology, Prevention and Treatment of Head and Neck Cance
    NIH/NIDCR R13DE021296Jul 1, 2010 - Jun 30, 2011
    Role: Principal Investigator
    Head and Neck Cancer SPORE
    NIH/NCI P50CA097190Aug 1, 2009 - Jun 30, 2020
    Role: Co-Principal Investigator
    Clinical and Transtional Science Institute
    NIH/NCATS KL2TR000143Sep 30, 2006 - Jun 30, 2016
    Role: Principal Investigator
    Clinical and Transtional Science Institute
    NIH/NCATS TL1TR000144Sep 30, 2006 - Jun 30, 2016
    Role: Principal Investigator
    Conf. on Research Education &Training in Otolaryngology
    NIH/NIDCD R13DC007325Jul 1, 2005 - Jun 30, 2006
    Role: Principal Investigator
    Stat3 as a Therapeutic Target in Head and Neck Cancer
    NIH/NCI R01CA101840Aug 1, 2004 - May 31, 2010
    Role: Principal Investigator
    GPCR Signaling in SCCHN: Integration with EGFR
    NIH/NCI R01CA098372Apr 1, 2004 - May 31, 2018
    Role: Principal Investigator
    Imaging of EGFR Targeting in Head and Neck Cancer
    NIH/NCI R21CA096815Jul 1, 2003 - Jun 30, 2006
    Role: Principal Investigator
    Research Training in Otolaryngology
    NIH/NIDCD T32DC000066Jul 1, 2001 - Jun 30, 2018
    Role: Co-Principal Investigator
    ORAL CANCER CENTER
    NIH P60DE013059Aug 1, 1999 - Jul 31, 2006
    Role: Co-Investigator
    STAT Mediated TGF-a/EGFR Signaling in Squamous Cell Carcinomas of Head & Neck
    NIH/NCI R01CA077308Aug 1, 1998 - May 31, 2019
    Role: Principal Investigator
    TGF-ALPHA AND EGFR EXPRESSION IN HEAD AND NECK CANCER
    NIH/NCI R03CA072526Sep 30, 1996 - Sep 29, 1999
    Role: Principal Investigator
    Postdoctoral Research Training in Head and Neck Oncology
    NIH/NCI T32CA060397Jun 1, 1994 - Mar 31, 1999
    Role: Co-Principal Investigator
    AUTOCRINE GROWTH IN HEAD AND NECK CANCER
    NIH/NCI K11CA001760Jul 1, 1993 - Jun 30, 1998
    Role: Principal Investigator
    Cancer Center Support Grant
    NIH P30CA047904Aug 1, 1988 - Jul 31, 2020
    Role: Co-Investigator
    General Clinical Research Center
    NIH/NCRR M01RR000056Dec 1, 1978 - Sep 29, 2006
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
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    Collapse In The News
    Collapse Student Projects
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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Phase I Study of Ficlatuzumab and Cetuximab in Cetuximab-Resistant, Recurrent/Metastatic Head and Neck Cancer. Cancers (Basel). 2020 Jun 11; 12(6). Bauman JE, Ohr J, Gooding WE, Ferris RL, Duvvuri U, Kim S, Johnson JT, Soloff AC, Wallweber G, Winslow J, Gaither-Davis A, Grandis JR, Stabile LP. PMID: 32545260.
      View in: PubMed   Mentions:
    2. Pathway-specific genome editing of PI3K/mTOR tumor suppressor genes reveals that PTEN loss contributes to cetuximab resistance in head and neck cancer. Mol Cancer Ther. 2020 May 19. Izumi H, Wang Z, Goto Y, Ando T, Wu X, Zhang X, Li H, Johnson DE, Grandis JR, Gutkind JS. PMID: 32430488.
      View in: PubMed   Mentions:    Fields:    
    3. MAPK pathway mutations in head and neck cancer affect immune microenvironments and ErbB3 signaling. Life Sci Alliance. 2020 Jun; 3(6). Ngan HL, Liu Y, Fong AY, Poon PHY, Yeung CK, Chan SSM, Lau A, Piao W, Li H, Tse JSW, Lo KW, Chan SM, Su YX, Chan JYK, Lau CW, Mills GB, Grandis JR, Lui VWY. PMID: 32381551.
      View in: PubMed   Mentions:    Fields:    
    4. Alterations and molecular targeting of the GSK-3 regulator, PI3K, in head and neck cancer. Biochim Biophys Acta Mol Cell Res. 2020 Jun; 1867(6):118679. Lee MJ, Jin N, Grandis JR, Johnson DE. PMID: 32061630.
      View in: PubMed   Mentions:    Fields:    
    5. Interleukin 6 is increased in preclinical HNSCC models of acquired cetuximab resistance, but is not required for maintenance of resistance. PLoS One. 2020; 15(1):e0227261. O'Keefe RA, Bhola NE, Lee DS, Johnson DE, Grandis JR. PMID: 31914141.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    6. Targeting STAT3 in Cancer with Nucleotide Therapeutics. Cancers (Basel). 2019 10 29; 11(11). Lau YK, Ramaiyer M, Johnson DE, Grandis JR. PMID: 31671769.
      View in: PubMed   Mentions:
    7. Gene targets of sulforaphane in head and neck squamous cell carcinoma. Mol Med Rep. 2019 Dec; 20(6):5335-5344. Hu L, Li H, Lee ED, Grandis JR, Bauman JE, Johnson DE. PMID: 31661135.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    8. NSAID therapy for PIK3CA-Altered colorectal, breast, and head and neck cancer. Adv Biol Regul. 2020 01; 75:100653. Cai Y, Yousef A, Grandis JR, Johnson DE. PMID: 31594701.
      View in: PubMed   Mentions: 1     Fields:    
    9. Molecular and Clinical Activity of CDX-3379, an Anti-ErbB3 Monoclonal Antibody, in Head and Neck Squamous Cell Carcinoma Patients. Clin Cancer Res. 2019 10 01; 25(19):5752-5758. Duvvuri U, George J, Kim S, Alvarado D, Neumeister VM, Chenna A, Gedrich R, Hawthorne T, LaVallee T, Grandis JR, Bauman JE. PMID: 31308059.
      View in: PubMed   Mentions:    Fields:    
    10. HER3 targeting potentiates growth suppressive effects of the PI3K inhibitor BYL719 in pre-clinical models of head and neck squamous cell carcinoma. Sci Rep. 2019 06 24; 9(1):9130. Meister KS, Godse NR, Khan NI, Hedberg ML, Kemp C, Kulkarni S, Alvarado D, LaVallee T, Kim S, Grandis JR, Duvvuri U. PMID: 31235758.
      View in: PubMed   Mentions:    Fields:    
    11. ATR inhibition sensitizes HPV- and HPV+ head and neck squamous cell carcinoma to cisplatin. Oral Oncol. 2019 08; 95:35-42. Leonard BC, Lee ED, Bhola NE, Li H, Sogaard KK, Bakkenist CJ, Grandis JR, Johnson DE. PMID: 31345392.
      View in: PubMed   Mentions:    Fields:    
    12. Investigational multitargeted kinase inhibitors in development for head and neck neoplasms. Expert Opin Investig Drugs. 2019 04; 28(4):351-363. Sola AM, Johnson DE, Grandis JR. PMID: 30753792.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    13. Correction: Treatment of Triple-Negative Breast Cancer with TORC1/2 Inhibitors Sustains a Drug-Resistant and Notch-Dependent Cancer Stem Cell Population. Cancer Res. 2019 Feb 15; 79(4):875. Bhola NE, Jansen VM, Koch JP, Li H, Formisano L, Williams JA, Grandis JR, Arteaga CL. PMID: 30770370.
      View in: PubMed   Mentions:    Fields:    
    14. Use of nonsteroidal anti-inflammatory drugs predicts improved patient survival for PIK3CA-altered head and neck cancer. J Exp Med. 2019 02 04; 216(2):419-427. Hedberg ML, Peyser ND, Bauman JE, Gooding WE, Li H, Bhola NE, Zhu TR, Zeng Y, Brand TM, Kim MO, Jordan RCK, VandenBerg S, Olivas V, Bivona TG, Chiosea SI, Wang L, Mills GB, Johnson JT, Duvvuri U, Ferris RL, Ha P, Johnson DE, Grandis JR. PMID: 30683736.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCTClinical Trials
    15. APOBEC-induced mutations and their cancer effect size in head and neck squamous cell carcinoma. Oncogene. 2019 05; 38(18):3475-3487. Cannataro VL, Gaffney SG, Sasaki T, Issaeva N, Grewal NKS, Grandis JR, Yarbrough WG, Burtness B, Anderson KS, Townsend JP. PMID: 30647454.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    16. An update: emerging drugs to treat squamous cell carcinomas of the head and neck. Expert Opin Emerg Drugs. 2018 12; 23(4):283-299. Lee YS, Johnson DE, Grandis JR. PMID: 30376740.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    17. Analysis of oncogenic activities of protein kinase D1 in head and neck squamous cell carcinoma. BMC Cancer. 2018 Nov 12; 18(1):1107. Zhang L, Li Z, Liu Y, Xu S, Tandon M, Appelboom B, LaValle CR, Chiosea SI, Wang L, Sen M, Lui VWY, Grandis JR, Wang QJ. PMID: 30419840.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    18. Overexpression-mediated activation of MET in the Golgi promotes HER3/ERBB3 phosphorylation. Oncogene. 2019 03; 38(11):1936-1950. Frazier NM, Brand T, Gordan JD, Grandis J, Jura N. PMID: 30390071.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    19. Phase 1 study of EGFR-antisense DNA, cetuximab, and radiotherapy in head and neck cancer with preclinical correlatives. Cancer. 2018 10 01; 124(19):3881-3889. Bauman JE, Duvvuri U, Thomas S, Gooding WE, Clump DA, Karlovits B, Wehbe A, Miller FR, Kim S, Sen M, Heron DE, Grandis JR, Argiris A. PMID: 30291796.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    20. Multiple Routes to Oncogenesis Are Promoted by the Human Papillomavirus-Host Protein Network. Cancer Discov. 2018 11; 8(11):1474-1489. Eckhardt M, Zhang W, Gross AM, Von Dollen J, Johnson JR, Franks-Skiba KE, Swaney DL, Johnson TL, Jang GM, Shah PS, Brand TM, Archambault J, Kreisberg JF, Grandis JR, Ideker T, Krogan NJ. PMID: 30209081.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    21. STAT3 Cyclic Decoy Demonstrates Robust Antitumor Effects in Non-Small Cell Lung Cancer. Mol Cancer Ther. 2018 09; 17(9):1917-1926. Njatcha C, Farooqui M, Kornberg A, Johnson DE, Grandis JR, Siegfried JM. PMID: 29891486.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    22. Biochemical Properties of a Decoy Oligodeoxynucleotide Inhibitor of STAT3 Transcription Factor. Int J Mol Sci. 2018 May 30; 19(6). Lee DS, O'Keefe RA, Ha PK, Grandis JR, Johnson DE. PMID: 29848966.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    23. BET Inhibition Overcomes Receptor Tyrosine Kinase-Mediated Cetuximab Resistance in HNSCC. Cancer Res. 2018 08 01; 78(15):4331-4343. Leonard B, Brand TM, O'Keefe RA, Lee ED, Zeng Y, Kemmer JD, Li H, Grandis JR, Bhola NE. PMID: 29792310.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    24. New Therapies in Head and Neck Cancer. Trends Cancer. 2018 05; 4(5):385-396. Santuray RT, Johnson DE, Grandis JR. PMID: 29709262.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    25. Cross-talk Signaling between HER3 and HPV16 E6 and E7 Mediates Resistance to PI3K Inhibitors in Head and Neck Cancer. Cancer Res. 2018 05 01; 78(9):2383-2395. Brand TM, Hartmann S, Bhola NE, Li H, Zeng Y, O'Keefe RA, Ranall MV, Bandyopadhyay S, Soucheray M, Krogan NJ, Kemp C, Duvvuri U, LaVallee T, Johnson DE, Ozbun MA, Bauman JE, Grandis JR. PMID: 29440171.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    26. Leveraging Genomics for Head and Neck Cancer Treatment. J Dent Res. 2018 06; 97(6):603-613. Kemmer JD, Johnson DE, Grandis JR. PMID: 29420101.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    27. Targeting the IL-6/JAK/STAT3 signalling axis in cancer. Nat Rev Clin Oncol. 2018 04; 15(4):234-248. Johnson DE, O'Keefe RA, Grandis JR. PMID: 29405201.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansCells
    28. Therapeutic Implications of the Genetic Landscape of Head and Neck Cancer. Semin Radiat Oncol. 2018 01; 28(1):2-11. Cho J, Johnson DE, Grandis JR. PMID: 29173752.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    29. High Content Imaging Assays for IL-6-Induced STAT3 Pathway Activation in Head and Neck Cancer Cell Lines. Methods Mol Biol. 2018; 1683:229-244. Johnston PA, Sen M, Hua Y, Camarco DP, Shun TY, Lazo JS, Grandis JR. PMID: 29082496.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    30. The RARS-MAD1L1 Fusion Gene Induces Cancer Stem Cell-like Properties and Therapeutic Resistance in Nasopharyngeal Carcinoma. Clin Cancer Res. 2018 02 01; 24(3):659-673. Zhong Q, Liu ZH, Lin ZR, Hu ZD, Yuan L, Liu YM, Zhou AJ, Xu LH, Hu LJ, Wang ZF, Guan XY, Hao JJ, Lui VWY, Guo L, Mai HQ, Chen MY, Han F, Xia YF, Grandis JR, Zhang X, Zeng MS. PMID: 29133573.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    31. Prognostic biomarkers in patients with human immunodeficiency virus-positive disease with head and neck squamous cell carcinoma. Head Neck. 2017 12; 39(12):2433-2443. Zhang H, Kim S, Chen Z, Nannapaneni S, Chen AY, Moore CE, Sica G, Mosunjac M, Nguyen MLT, D'Souza G, Carey TE, Peterson LA, McHugh JB, Graham M, Komarck CM, Wolf GT, Walline HM, Bellile E, Riddell J, Pai SI, Sidransky D, Westra WH, William WN, Lee JJ, El-Naggar AK, Ferris RL, Seethala R, Grandis JR, Chen ZG, Saba NF, Shin DM. PMID: 28945296.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    32. EGFR-targeted therapies in the post-genomic era. Cancer Metastasis Rev. 2017 09; 36(3):463-473. Xu MJ, Johnson DE, Grandis JR. PMID: 28866730.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    33. The fourth edition of the head and neck World Health Organization blue book: editors' perspectives. Hum Pathol. 2017 08; 66:10-12. El-Naggar AK, Chan JKC, Takata T, Grandis JR, Slootweg PJ. PMID: 28583885.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    34. Rational combination therapy with PARP and MEK inhibitors capitalizes on therapeutic liabilities in RAS mutant cancers. Sci Transl Med. 2017 05 31; 9(392). Sun C, Fang Y, Yin J, Chen J, Ju Z, Zhang D, Chen X, Vellano CP, Jeong KJ, Ng PK, Eterovic AKB, Bhola NH, Lu Y, Westin SN, Grandis JR, Lin SY, Scott KL, Peng G, Brugge J, Mills GB. PMID: 28566428.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    35. Mechanism of action of selective inhibitors of IL-6 induced STAT3 pathway in head and neck cancer cell lines. J Chem Biol. 2017 Jul; 10(3):129-141. Sen M, Johnston PA, Pollock NI, DeGrave K, Joyce SC, Freilino ML, Hua Y, Camarco DP, Close DA, Huryn DM, Wipf P, Grandis JR. PMID: 28684999.
      View in: PubMed   Mentions:
    36. IL6 is associated with response to dasatinib and cetuximab: Phase II clinical trial with mechanistic correlatives in cetuximab-resistant head and neck cancer. Oral Oncol. 2017 06; 69:38-45. Stabile LP, Egloff AM, Gibson MK, Gooding WE, Ohr J, Zhou P, Rothenberger NJ, Wang L, Geiger JL, Flaherty JT, Grandis JR, Bauman JE. PMID: 28559019.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCTClinical Trials
    37. TMEM16A/ANO1 suppression improves response to antibody-mediated targeted therapy of EGFR and HER2/ERBB2. Genes Chromosomes Cancer. 2017 06; 56(6):460-471. Kulkarni S, Bill A, Godse NR, Khan NI, Kass JI, Steehler K, Kemp C, Davis K, Bertrand CA, Vyas AR, Holt DE, Grandis JR, Gaither LA, Duvvuri U. PMID: 28177558.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    38. Randomized, placebo-controlled window trial of EGFR, Src, or combined blockade in head and neck cancer. JCI Insight. 2017 03 23; 2(6):e90449. Bauman JE, Duvvuri U, Gooding WE, Rath TJ, Gross ND, Song J, Jimeno A, Yarbrough WG, Johnson FM, Wang L, Chiosea S, Sen M, Kass J, Johnson JT, Ferris RL, Kim S, Hirsch FR, Ellison K, Flaherty JT, Mills GB, Grandis JR. PMID: 28352657.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    39. Nonpromoter methylation of the CDKN2A gene with active transcription is associated with improved locoregional control in laryngeal squamous cell carcinoma. Cancer Med. 2017 02; 6(2):397-407. Ben-Dayan MM, Ow TJ, Belbin TJ, Wetzler J, Smith RV, Childs G, Diergaarde B, Hayes DN, Grandis JR, Prystowsky MB, Schlecht NF. PMID: 28102032.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    40. Exome and genome sequencing of nasopharynx cancer identifies NF-?B pathway activating mutations. Nat Commun. 2017 01 18; 8:14121. Li YY, Chung GT, Lui VW, To KF, Ma BB, Chow C, Woo JK, Yip KY, Seo J, Hui EP, Mak MK, Rusan M, Chau NG, Or YY, Law MH, Law PP, Liu ZW, Ngan HL, Hau PM, Verhoeft KR, Poon PH, Yoo SK, Shin JY, Lee SD, Lun SW, Jia L, Chan AW, Chan JY, Lai PB, Fung CY, Hung ST, Wang L, Chang AM, Chiosea SI, Hedberg ML, Tsao SW, van Hasselt AC, Chan AT, Grandis JR, Hammerman PS, Lo KW. PMID: 28098136.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    41. Cancer genomics: Spot the difference. Nature. 2017 01 12; 541(7636):162-163. Peyser ND, Grandis JR. PMID: 28052059.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    42. Human Papillomavirus Regulates HER3 Expression in Head and Neck Cancer: Implications for Targeted HER3 Therapy in HPV+ Patients. Clin Cancer Res. 2017 Jun 15; 23(12):3072-3083. Brand TM, Hartmann S, Bhola NE, Peyser ND, Li H, Zeng Y, Isaacson Wechsler E, Ranall MV, Bandyopadhyay S, Duvvuri U, LaVallee TM, Jordan RCK, Johnson DE, Grandis JR. PMID: 27986750.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    43. Head and neck cancer in 2016: A watershed year for improvements in treatment? Nat Rev Clin Oncol. 2017 Feb; 14(2):76-78. Algazi AP, Grandis JR. PMID: 27922045.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    44. Genomic and Transcriptomic Alterations Associated with STAT3 Activation in Head and Neck Cancer. PLoS One. 2016; 11(11):e0166185. Peyser ND, Pendleton K, Gooding WE, Lui VW, Johnson DE, Grandis JR. PMID: 27855189.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    45. Toxicity, pharmacokinetics and metabolism of a novel inhibitor of IL-6-induced STAT3 activation. Cancer Chemother Pharmacol. 2016 Dec; 78(6):1225-1235. Kiesel BF, Parise RA, Guo J, Huryn DM, Johnston PA, Colombo R, Sen M, Grandis JR, Beumer JH, Eiseman JL. PMID: 27778071.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    46. Genome-wide association analyses identify new susceptibility loci for oral cavity and pharyngeal cancer. Nat Genet. 2016 12; 48(12):1544-1550. Lesseur C, Diergaarde B, Olshan AF, Wünsch-Filho V, Ness AR, Liu G, Lacko M, Eluf-Neto J, Franceschi S, Lagiou P, Macfarlane GJ, Richiardi L, Boccia S, Polesel J, Kjaerheim K, Zaridze D, Johansson M, Menezes AM, Curado MP, Robinson M, Ahrens W, Canova C, Znaor A, Castellsagué X, Conway DI, Holcátová I, Mates D, Vilensky M, Healy CM, Szeszenia-Dabrowska N, Fabiánová E, Lissowska J, Grandis JR, Weissler MC, Tajara EH, Nunes FD, de Carvalho MB, Thomas S, Hung RJ, Peters WH, Herrero R, Cadoni G, Bueno-de-Mesquita HB, Steffen A, Agudo A, Shangina O, Xiao X, Gaborieau V, Chabrier A, Anantharaman D, Boffetta P, Amos CI, McKay JD, Brennan P. PMID: 27749845.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    47. A sensible approach to targeting STAT3-mediated transcription. Ann Transl Med. 2016 Oct; 4(Suppl 1):S57. Bhola NE, Johnson DE, Grandis JR. PMID: 27868025.
      View in: PubMed   Mentions:
    48. Treatment of head and neck cancer in the elderly. Expert Opin Pharmacother. 2016 Oct; 17(14):1903-21. Hartmann S, Grandis JR. PMID: 27643444.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    49. The non-coding landscape of head and neck squamous cell carcinoma. Oncotarget. 2016 08 09; 7(32):51211-51222. Zou AE, Zheng H, Saad MA, Rahimy M, Ku J, Kuo SZ, Honda TK, Wang-Rodriguez J, Xuan Y, Korrapati A, Yu V, Singh P, Grandis JR, King CC, Lippman SM, Wang XQ, Hinton A, Ongkeko WM. PMID: 27323410.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    50. New Strategies in Esophageal Carcinoma: Translational Insights from Signaling Pathways and Immune Checkpoints. Clin Cancer Res. 2016 Sep 01; 22(17):4283-90. Wang VE, Grandis JR, Ko AH. PMID: 27370606.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    51. HGF/Met Signaling in Head and Neck Cancer: Impact on the Tumor Microenvironment. Clin Cancer Res. 2016 Aug 15; 22(16):4005-13. Hartmann S, Bhola NE, Grandis JR. PMID: 27370607.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    52. Prevention of Carcinogen-Induced Oral Cancer by Sulforaphane. Cancer Prev Res (Phila). 2016 Jul; 9(7):547-57. Bauman JE, Zang Y, Sen M, Li C, Wang L, Egner PA, Fahey JW, Normolle DP, Grandis JR, Kensler TW, Johnson DE. PMID: 27339168.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    53. Optimization of pyrazole-containing 1,2,4-triazolo-[3,4-b]thiadiazines, a new class of STAT3 pathway inhibitors. Bioorg Med Chem Lett. 2016 08 01; 26(15):3581-5. LaPorte MG, Wang Z, Colombo R, Garzan A, Peshkov VA, Liang M, Johnston PA, Schurdak ME, Sen M, Camarco DP, Hua Y, Pollock NI, Lazo JS, Grandis JR, Wipf P, Huryn DM. PMID: 27381083.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    54. STAT3 as a Chemoprevention Target in Carcinogen-Induced Head and Neck Squamous Cell Carcinoma. Cancer Prev Res (Phila). 2016 Aug; 9(8):657-63. Peyser ND, Wang L, Zeng Y, Acquafondata M, Freilino M, Li H, Sen M, Gooding WE, Satake M, Wang Z, Johnson DE, Grandis JR. PMID: 27267892.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    55. Phase II trial of everolimus in patients with previously treated recurrent or metastatic head and neck squamous cell carcinoma. Head Neck. 2016 12; 38(12):1759-1764. Geiger JL, Bauman JE, Gibson MK, Gooding WE, Varadarajan P, Kotsakis A, Martin D, Gutkind JS, Hedberg ML, Grandis JR, Argiris A. PMID: 27232378.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCTClinical Trials
    56. Phase II randomized trial of radiation therapy, cetuximab, and pemetrexed with or without bevacizumab in patients with locally advanced head and neck cancer. Ann Oncol. 2016 08; 27(8):1594-600. Argiris A, Bauman JE, Ohr J, Gooding WE, Heron DE, Duvvuri U, Kubicek GJ, Posluszny DM, Vassilakopoulou M, Kim S, Grandis JR, Johnson JT, Gibson MK, Clump DA, Flaherty JT, Chiosea SI, Branstetter B, Ferris RL. PMID: 27177865.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCTClinical Trials
    57. The degree of intratumor mutational heterogeneity varies by primary tumor sub-site. Oncotarget. 2016 May 10; 7(19):27185-98. Ledgerwood LG, Kumar D, Eterovic AK, Wick J, Chen K, Zhao H, Tazi L, Manna P, Kerley S, Joshi R, Wang L, Chiosea SI, Garnett JD, Tsue TT, Chien J, Mills GB, Grandis JR, Thomas SM. PMID: 27034009.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    58. MAPK1E322K mutation increases head and neck squamous cell carcinoma sensitivity to erlotinib through enhanced secretion of amphiregulin. Oncotarget. 2016 Apr 26; 7(17):23300-11. Wen Y, Li H, Zeng Y, Wen W, Pendleton KP, Lui VW, Egloff AM, Grandis JR. PMID: 27004400.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    59. Corrigendum to "Cetuximab activity in dysplastic lesions of the upper aerodigestive tract" [Oral Oncol. 53 (2016) 60-66]. Oral Oncol. 2016 Jun; 57:e8. Khan Z, Epstein JB, Marur S, Boyd Gillespie M, Feldman L, Tsai HL, Zhang Z, Wang H, Sciubba J, Ferris RL, Grandis JR, Gibson M, Koch W, Tufano R, Westra W, Tsottles N, Ozawa H, Chung CH, Califano JA. PMID: 27085635.
      View in: PubMed   Mentions:    Fields:    
    60. Genetic landscape of metastatic and recurrent head and neck squamous cell carcinoma. J Clin Invest. 2016 Apr 01; 126(4):1606. Hedberg ML, Goh G, Chiosea SI, Bauman JE, Freilino ML, Zeng Y, Wang L, Diergaarde BB, Gooding WE, Lui VW, Herbst RS, Lifton RP, Grandis JR. PMID: 27035818.
      View in: PubMed   Mentions: 7     Fields:    
    61. HER2 and HER3 in HPV+ and HPV- HNSCC--Response. Clin Cancer Res. 2016 Apr 01; 22(7):1826. Grandis J. PMID: 27037255.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    62. Oral Cancer Chemoprevention--The End of EPOC, the Beginning of an Epoch of Molecular Selection. JAMA Oncol. 2016 Feb; 2(2):178-9. Bauman JE, Grandis J. PMID: 26540592.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    63. A Young Man With Chronic Discharge From the Skin of the Lateral Neck. Thyroglossal duct fistula. JAMA Otolaryngol Head Neck Surg. 2016 Jan; 142(1):99-100. Prabhu AV, Grandis J, Branstetter BF. PMID: 26720864.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    64. The STAT3 pathway as a therapeutic target in head and neck cancer: Barriers and innovations. Oral Oncol. 2016 May; 56:84-92. Geiger JL, Grandis JR, Bauman JE. PMID: 26733183.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    65. Proteomic Characterization of Head and Neck Cancer Patient-Derived Xenografts. Mol Cancer Res. 2016 Mar; 14(3):278-86. Li H, Wheeler S, Park Y, Ju Z, Thomas SM, Fichera M, Egloff AM, Lui VW, Duvvuri U, Bauman JE, Mills GB, Grandis JR. PMID: 26685214.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimals
    66. Treatment of Triple-Negative Breast Cancer with TORC1/2 Inhibitors Sustains a Drug-Resistant and Notch-Dependent Cancer Stem Cell Population. Cancer Res. 2016 Jan 15; 76(2):440-52. Bhola NE, Jansen VM, Koch JP, Li H, Formisano L, Williams JA, Grandis JR, Arteaga CL. PMID: 26676751.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    67. Cetuximab activity in dysplastic lesions of the upper aerodigestive tract. Oral Oncol. 2016 Feb; 53:60-6. Khan Z, Epstein JB, Marur S, Gillespie MB, Feldman L, Tsai HL, Zhang Z, Wang H, Sciubba J, Ferris R, Grandis JR, Gibson M, Koch W, Tufano R, Westra W, Tsottles N, Ozawa H, Chung C, Califano JA. PMID: 26686755.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCTClinical Trials
    68. Genetic landscape of metastatic and recurrent head and neck squamous cell carcinoma. J Clin Invest. 2016 Jan; 126(1):169-80. Hedberg ML, Goh G, Chiosea SI, Bauman JE, Freilino ML, Zeng Y, Wang L, Diergaarde BB, Gooding WE, Lui VW, Herbst RS, Lifton RP, Grandis JR. PMID: 26619122.
      View in: PubMed   Mentions: 32     Fields:    Translation:Humans
    69. Nucleic acid targeting: towards personalized therapy for head and neck cancer. Oncogene. 2016 06 23; 35(25):3217-26. Parsel SM, Grandis JR, Thomas SM. PMID: 26592450.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    70. PRMT1-mediated methylation of the EGF receptor regulates signaling and cetuximab response. J Clin Invest. 2015 Dec; 125(12):4529-43. Liao HW, Hsu JM, Xia W, Wang HL, Wang YN, Chang WC, Arold ST, Chou CK, Tsou PH, Yamaguchi H, Fang YF, Lee HJ, Lee HH, Tai SK, Yang MH, Morelli MP, Sen M, Ladbury JE, Chen CH, Grandis JR, Kopetz S, Hung MC. PMID: 26571401.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    71. MicroRNA-363 targets myosin 1B to reduce cellular migration in head and neck cancer. BMC Cancer. 2015 Nov 06; 15:861. Chapman BV, Wald AI, Akhtar P, Munko AC, Xu J, Gibson SP, Grandis JR, Ferris RL, Khan SA. PMID: 26545583.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    72. Ultrasound Targeted Microbubble Destruction-Mediated Delivery of a Transcription Factor Decoy Inhibits STAT3 Signaling and Tumor Growth. Theranostics. 2015; 5(12):1378-87. Kopechek JA, Carson AR, McTiernan CF, Chen X, Hasjim B, Lavery L, Sen M, Grandis JR, Villanueva FS. PMID: 26681983.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    73. HCS campaign to identify selective inhibitors of IL-6-induced STAT3 pathway activation in head and neck cancer cell lines. Assay Drug Dev Technol. 2015 Sep; 13(7):356-76. Johnston PA, Sen M, Hua Y, Camarco DP, Shun TY, Lazo JS, Wilson GM, Resnick LO, LaPorte MG, Wipf P, Huryn DM, Grandis JR. PMID: 26317883.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    74. HPV-Associated Head and Neck Cancer: Unique Features of Epidemiology and Clinical Management. Annu Rev Med. 2016; 67:91-101. Maxwell JH, Grandis JR, Ferris RL. PMID: 26332002.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    75. Loss-of-Function PTPRD Mutations Lead to Increased STAT3 Activation and Sensitivity to STAT3 Inhibition in Head and Neck Cancer. PLoS One. 2015; 10(8):e0135750. Peyser ND, Du Y, Li H, Lui V, Xiao X, Chan TA, Grandis JR. PMID: 26267899.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    76. Increased Expression of HER2, HER3, and HER2:HER3 Heterodimers in HPV-Positive HNSCC Using a Novel Proximity-Based Assay: Implications for Targeted Therapies. Clin Cancer Res. 2015 Oct 15; 21(20):4597-606. Pollock NI, Wang L, Wallweber G, Gooding WE, Huang W, Chenna A, Winslow J, Sen M, DeGrave KA, Li H, Zeng Y, Grandis JR. PMID: 26138066.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    77. Frequent promoter hypermethylation of PTPRT increases STAT3 activation and sensitivity to STAT3 inhibition in head and neck cancer. Oncogene. 2016 Mar 03; 35(9):1163-9. Peyser ND, Freilino M, Wang L, Zeng Y, Li H, Johnson DE, Grandis JR. PMID: 25982282.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    78. Genomic Correlate of Exceptional Erlotinib Response in Head and Neck Squamous Cell Carcinoma. JAMA Oncol. 2015 May; 1(2):238-44. Van Allen EM, Lui VW, Egloff AM, Goetz EM, Li H, Johnson JT, Duvvuri U, Bauman JE, Stransky N, Zeng Y, Gilbert BR, Pendleton KP, Wang L, Chiosea S, Sougnez C, Wagle N, Zhang F, Du Y, Close D, Johnston PA, McKenna A, Carter SL, Golub TR, Getz G, Mills GB, Garraway LA, Grandis JR. PMID: 26181029.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    79. Emerging drugs for head and neck cancer. Expert Opin Emerg Drugs. 2015 Jun; 20(2):313-29. Wen Y, Grandis JR. PMID: 25826749.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    80. JAK kinase inhibition abrogates STAT3 activation and head and neck squamous cell carcinoma tumor growth. Neoplasia. 2015 Mar; 17(3):256-64. Sen M, Pollock NI, Black J, DeGrave KA, Wheeler S, Freilino ML, Joyce S, Lui VW, Zeng Y, Chiosea SI, Grandis JR. PMID: 25810010.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    81. Challenges in EGFRvIII detection in head and neck squamous cell carcinoma. PLoS One. 2015; 10(2):e0117781. Wheeler SE, Egloff AM, Wang L, James CD, Hammerman PS, Grandis JR. PMID: 25658924.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCellsCTClinical Trials
    82. Therapeutic insights from genomic studies of head and neck squamous cell carcinomas. Cancer Discov. 2015 Mar; 5(3):239-44. Hammerman PS, Hayes DN, Grandis JR. PMID: 25643909.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    83. Incidence of head and neck squamous cell carcinoma among subjects at high risk of lung cancer: results from the Pittsburgh Lung Screening Study. Cancer. 2015 May 01; 121(9):1431-5. Dixit R, Weissfeld JL, Wilson DO, Balogh P, Sufka P, Siegfried JM, Grandis JR, Diergaarde B. PMID: 25559556.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    84. Identification of epidermal growth factor receptor (EGFR) genetic variants that modify risk for head and neck squamous cell carcinoma. Cancer Lett. 2015 Feb 28; 357(2):549-56. Fung C, Zhou P, Joyce S, Trent K, Yuan JM, Grandis JR, Weissfeld JL, Romkes M, Weeks DE, Egloff AM. PMID: 25511740.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    85. HER2 as a therapeutic target in head and neck squamous cell carcinoma. Clin Cancer Res. 2015 Feb 01; 21(3):526-33. Pollock NI, Grandis JR. PMID: 25424855.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    86. Receptor-type protein tyrosine phosphatases in cancer. Chin J Cancer. 2015 Feb; 34(2):61-9. Du Y, Grandis JR. PMID: 25322863.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    87. Characterization of HPV and host genome interactions in primary head and neck cancers. Proc Natl Acad Sci U S A. 2014 Oct 28; 111(43):15544-9. Parfenov M, Pedamallu CS, Gehlenborg N, Freeman SS, Danilova L, Bristow CA, Lee S, Hadjipanayis AG, Ivanova EV, Wilkerson MD, Protopopov A, Yang L, Seth S, Song X, Tang J, Ren X, Zhang J, Pantazi A, Santoso N, Xu AW, Mahadeshwar H, Wheeler DA, Haddad RI, Jung J, Ojesina AI, Issaeva N, Yarbrough WG, Hayes DN, Grandis JR, El-Naggar AK, Meyerson M, Park PJ, Chin L, Seidman JG, Hammerman PS, Kucherlapati R. PMID: 25313082.
      View in: PubMed   Mentions: 84     Fields:    Translation:HumansCells
    88. 2-Guanidinoquinazolines as new inhibitors of the STAT3 pathway. Bioorg Med Chem Lett. 2014 Nov 01; 24(21):5081-5. LaPorte MG, da Paz Lima DJ, Zhang F, Sen M, Grandis JR, Camarco D, Hua Y, Johnston PA, Lazo JS, Resnick LO, Wipf P, Huryn DM. PMID: 25288188.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    89. Quantifying metabolic heterogeneity in head and neck tumors in real time: 2-DG uptake is highest in hypoxic tumor regions. PLoS One. 2014; 9(8):e102452. Nakajima EC, Laymon C, Oborski M, Hou W, Wang L, Grandis JR, Ferris RL, Mountz JM, Van Houten B. PMID: 25127378.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    90. Phase II study of cetuximab in combination with cisplatin and radiation in unresectable, locally advanced head and neck squamous cell carcinoma: Eastern cooperative oncology group trial E3303. Clin Cancer Res. 2014 Oct 01; 20(19):5041-51. Egloff AM, Lee JW, Langer CJ, Quon H, Vaezi A, Grandis JR, Seethala RR, Wang L, Shin DM, Argiris A, Yang D, Mehra R, Ridge JA, Patel UA, Burtness BA, Forastiere AA. PMID: 25107914.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCTClinical Trials
    91. Multi-tiered genomic analysis of head and neck cancer ties TP53 mutation to 3p loss. Nat Genet. 2014 Sep; 46(9):939-43. Gross AM, Orosco RK, Shen JP, Egloff AM, Carter H, Hofree M, Choueiri M, Coffey CS, Lippman SM, Hayes DN, Cohen EE, Grandis JR, Nguyen QT, Ideker T. PMID: 25086664.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansCells
    92. EGFR phosphorylation of DCBLD2 recruits TRAF6 and stimulates AKT-promoted tumorigenesis. J Clin Invest. 2014 Sep; 124(9):3741-56. Feng H, Lopez GY, Kim CK, Alvarez A, Duncan CG, Nishikawa R, Nagane M, Su AJ, Auron PE, Hedberg ML, Wang L, Raizer JJ, Kessler JA, Parsa AT, Gao WQ, Kim SH, Minata M, Nakano I, Grandis JR, McLendon RE, Bigner DD, Lin HK, Furnari FB, Cavenee WK, Hu B, Yan H, Cheng SY. PMID: 25061874.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    93. Identifying and quantifying heterogeneity in high content analysis: application of heterogeneity indices to drug discovery. PLoS One. 2014; 9(7):e102678. Gough AH, Chen N, Shun TY, Lezon TR, Boltz RC, Reese CE, Wagner J, Vernetti LA, Grandis JR, Lee AV, Stern AM, Schurdak ME, Taylor DL. PMID: 25036749.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    94. To "grow" or "go": TMEM16A expression as a switch between tumor growth and metastasis in SCCHN. Clin Cancer Res. 2014 Sep 01; 20(17):4673-88. Shiwarski DJ, Shao C, Bill A, Kim J, Xiao D, Bertrand CA, Seethala RS, Sano D, Myers JN, Ha P, Grandis J, Gaither LA, Puthenveedu MA, Duvvuri U. PMID: 24919570.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    95. Targeting secondary immune responses to cetuximab: CD137 and the outside story. J Clin Invest. 2014 Jun; 124(6):2371-5. Bauman JE, Grandis JR. PMID: 24837438.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    96. Caspase-8 mutations in head and neck cancer confer resistance to death receptor-mediated apoptosis and enhance migration, invasion, and tumor growth. Mol Oncol. 2014 Oct; 8(7):1220-30. Li C, Egloff AM, Sen M, Grandis JR, Johnson DE. PMID: 24816188.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    97. Epidemiology of head and neck squamous cell cancer among HIV-infected patients. J Acquir Immune Defic Syndr. 2014 Apr 15; 65(5):603-10. D'souza G, Carey TE, William WN, Nguyen ML, Ko EC, Riddell J, Pai SI, Gupta V, Walline HM, Lee JJ, Wolf GT, Shin DM, Grandis JR, Ferris RL. PMID: 24326607.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    98. Erlotinib, erlotinib-sulindac versus placebo: a randomized, double-blind, placebo-controlled window trial in operable head and neck cancer. Clin Cancer Res. 2014 Jun 15; 20(12):3289-98. Gross ND, Bauman JE, Gooding WE, Denq W, Thomas SM, Wang L, Chiosea S, Hood BL, Flint MS, Sun M, Conrads TP, Ferris RL, Johnson JT, Kim S, Argiris A, Wirth L, Nikiforova MN, Siegfried JM, Grandis JR. PMID: 24727329.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCTClinical Trials
    99. Systemic administration of a cyclic signal transducer and activator of transcription 3 (STAT3) decoy oligonucleotide inhibits tumor growth without inducing toxicological effects. Mol Med. 2014 Mar 18; 20:46-56. Sen M, Paul K, Freilino ML, Li H, Li C, Johnson DE, Wang L, Eiseman J, Grandis JR. PMID: 24395569.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    100. Identification of mutations in the PYRIN-containing NLR genes (NLRP) in Head and Neck Squamous Cell Carcinoma. PLoS One. 2014; 9(1):e85619. Lei Y, Lui VW, Grandis JR, Egloff AM. PMID: 24465623.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    101. Genomic analysis of head and neck squamous cell carcinoma cell lines and human tumors: a rational approach to preclinical model selection. Mol Cancer Res. 2014 Apr; 12(4):571-82. Li H, Wawrose JS, Gooding WE, Garraway LA, Lui VW, Peyser ND, Grandis JR. PMID: 24425785.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    102. Frequent mutation of receptor protein tyrosine phosphatases provides a mechanism for STAT3 hyperactivation in head and neck cancer. Proc Natl Acad Sci U S A. 2014 Jan 21; 111(3):1114-9. Lui VW, Peyser ND, Ng PK, Hritz J, Zeng Y, Lu Y, Li H, Wang L, Gilbert BR, General IJ, Bahar I, Ju Z, Wang Z, Pendleton KP, Xiao X, Du Y, Vries JK, Hammerman PS, Garraway LA, Mills GB, Johnson DE, Grandis JR. PMID: 24395800.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    103. STAT3 oligonucleotide inhibits tumor angiogenesis in preclinical models of squamous cell carcinoma. PLoS One. 2014; 9(1):e81819. Klein JD, Sano D, Sen M, Myers JN, Grandis JR, Kim S. PMID: 24404126.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    104. Genetic mutations in head and neck cancer: utilizing existing treatments. Pharmacogenomics. 2014; 15(12):1553-5. Peyser ND, Grandis JR. PMID: 25340729.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    105. PIK3CA, HRAS and PTEN in human papillomavirus positive oropharyngeal squamous cell carcinoma. BMC Cancer. 2013 Dec 17; 13:602. Chiosea SI, Grandis JR, Lui VW, Diergaarde B, Maxwell JH, Ferris RL, Kim SW, Luvison A, Miller M, Nikiforova MN. PMID: 24341335.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    106. Integration of molecular targeted therapy with radiation in head and neck cancer. Pharmacol Ther. 2014 Apr; 142(1):88-98. Du Y, Peyser ND, Grandis JR. PMID: 24280066.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimals
    107. Collagen type XI a1 facilitates head and neck squamous cell cancer growth and invasion. Br J Cancer. 2013 Dec 10; 109(12):3049-56. Sok JC, Lee JA, Dasari S, Joyce S, Contrucci SC, Egloff AM, Trevelline BK, Joshi R, Kumari N, Grandis JR, Thomas SM. PMID: 24231953.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    108. Single-agent obatoclax (GX15-070) potently induces apoptosis and pro-survival autophagy in head and neck squamous cell carcinoma cells. Oral Oncol. 2014 Feb; 50(2):120-7. Yazbeck VY, Li C, Grandis JR, Zang Y, Johnson DE. PMID: 24216166.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    109. High-content pSTAT3/1 imaging assays to screen for selective inhibitors of STAT3 pathway activation in head and neck cancer cell lines. Assay Drug Dev Technol. 2014 Jan-Feb; 12(1):55-79. Johnston PA, Sen M, Hua Y, Camarco D, Shun TY, Lazo JS, Grandis JR. PMID: 24127660.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    110. Chemoprevention of head and neck cancer with celecoxib and erlotinib: results of a phase ib and pharmacokinetic study. Cancer Prev Res (Phila). 2014 Mar; 7(3):283-91. Saba NF, Hurwitz SJ, Kono SA, Yang CS, Zhao Y, Chen Z, Sica G, Müller S, Moreno-Williams R, Lewis M, Grist W, Chen AY, Moore CE, Owonikoko TK, Ramalingam S, Beitler JJ, Nannapaneni S, Shin HJ, Grandis JR, Khuri FR, Chen ZG, Shin DM. PMID: 24085777.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCTClinical Trials
    111. Critical analysis of the potential for targeting STAT3 in human malignancy. Onco Targets Ther. 2013; 6:999-1010. Peyser ND, Grandis JR. PMID: 23935373.
      View in: PubMed   Mentions:
    112. Self-reinforcing loop of amphiregulin and Y-box binding protein-1 contributes to poor outcomes in ovarian cancer. Oncogene. 2014 May 29; 33(22):2846-56. Panupinthu N, Yu S, Zhang D, Zhang F, Gagea M, Lu Y, Grandis JR, Dunn SE, Lee HY, Mills GB. PMID: 23851501.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    113. Expression of EGFR, VEGF, and NOTCH1 suggest differences in tumor angiogenesis in HPV-positive and HPV-negative head and neck squamous cell carcinoma. Head Neck Pathol. 2013 Dec; 7(4):344-55. Troy JD, Weissfeld JL, Youk AO, Thomas S, Wang L, Grandis JR. PMID: 23645351.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    114. Frequent mutation of the PI3K pathway in head and neck cancer defines predictive biomarkers. Cancer Discov. 2013 Jul; 3(7):761-9. Lui VW, Hedberg ML, Li H, Vangara BS, Pendleton K, Zeng Y, Lu Y, Zhang Q, Du Y, Gilbert BR, Freilino M, Sauerwein S, Peyser ND, Xiao D, Diergaarde B, Wang L, Chiosea S, Seethala R, Johnson JT, Kim S, Duvvuri U, Ferris RL, Romkes M, Nukui T, Kwok-Shing Ng P, Garraway LA, Hammerman PS, Mills GB, Grandis JR. PMID: 23619167.
      View in: PubMed   Mentions: 159     Fields:    Translation:HumansCells
    115. Childhood passive smoke exposure is associated with adult head and neck cancer. Cancer Epidemiol. 2013 Aug; 37(4):417-23. Troy JD, Grandis JR, Youk AO, Diergaarde B, Romkes M, Weissfeld JL. PMID: 23619143.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansPHPublic Health
    116. Polymorphisms in NAT2 and GSTP1 are associated with survival in oral and oropharyngeal cancer. Cancer Epidemiol. 2013 Aug; 37(4):505-11. Troy JD, Weissfeld JL, Diergaarde B, Youk AO, Buch SC, Romkes M, Grandis JR. PMID: 23523331.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    117. Chemoprevention of head and neck cancer by simultaneous blocking of epidermal growth factor receptor and cyclooxygenase-2 signaling pathways: preclinical and clinical studies. Clin Cancer Res. 2013 Mar 01; 19(5):1244-56. Shin DM, Zhang H, Saba NF, Chen AY, Nannapaneni S, Amin AR, Müller S, Lewis M, Sica G, Kono S, Brandes JC, Grist WJ, Moreno-Williams R, Beitler JJ, Thomas SM, Chen Z, Shin HJ, Grandis JR, Khuri FR, Chen ZG. PMID: 23422093.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    118. The Fanconi anemia pathway: repairing the link between DNA damage and squamous cell carcinoma. Mutat Res. 2013 Mar-Apr; 743-744:78-88. Romick-Rosendale LE, Lui VW, Grandis JR, Wells SI. PMID: 23333482.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    119. Utility of 3'-[(18)F]fluoro-3'-deoxythymidine as a PET tracer to monitor response to gene therapy in a xenograft model of head and neck carcinoma. Am J Nucl Med Mol Imaging. 2013; 3(1):16-31. Mason NS, Lopresti BJ, Ruszkiewicz J, Dong X, Joyce S, Leef G, Sen M, Wahed AS, Mathis CA, Grandis JR, Thomas SM. PMID: 23342298.
      View in: PubMed   Mentions:
    120. Cisplatin-Based Chemotherapy Options for Recurrent and/or Metastatic Squamous Cell Cancer of the Head and Neck. Clin Med Insights Ther. 2013; 2013(5). Pendleton KP, Grandis JR. PMID: 24273416.
      View in: PubMed   Mentions:
    121. c-Src activation mediates erlotinib resistance in head and neck cancer by stimulating c-Met. Clin Cancer Res. 2013 Jan 15; 19(2):380-92. Stabile LP, He G, Lui VW, Thomas S, Henry C, Gubish CT, Joyce S, Quesnelle KM, Siegfried JM, Grandis JR. PMID: 23213056.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    122. Antitumor effects of EGFR antisense guanidine-based peptide nucleic acids in cancer models. ACS Chem Biol. 2013 Feb 15; 8(2):345-52. Thomas SM, Sahu B, Rapireddy S, Bahal R, Wheeler SE, Procopio EM, Kim J, Joyce SC, Contrucci S, Wang Y, Chiosea SI, Lathrop KL, Watkins S, Grandis JR, Armitage BA, Ly DH. PMID: 23113581.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    123. Targeting TORC1/2 enhances sensitivity to EGFR inhibitors in head and neck cancer preclinical models. Neoplasia. 2012 Nov; 14(11):1005-14. Cassell A, Freilino ML, Lee J, Barr S, Wang L, Panahandeh MC, Thomas SM, Grandis JR. PMID: 23226094.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimals
    124. Nucleic acid-based approaches to STAT inhibition. JAKSTAT. 2012 Oct 01; 1(4):285-91. Sen M, Grandis JR. PMID: 24058785.
      View in: PubMed   Mentions:
    125. The next generation proteasome inhibitors carfilzomib and oprozomib activate prosurvival autophagy via induction of the unfolded protein response and ATF4. Autophagy. 2012 Dec; 8(12):1873-4. Zang Y, Thomas SM, Chan ET, Kirk CJ, Freilino ML, DeLancey HM, Grandis JR, Li C, Johnson DE. PMID: 22995770.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    126. EGFR tyrosine kinase inhibition induces autophagy in cancer cells. Cancer Biol Ther. 2012 Dec; 13(14):1417-24. Fung C, Chen X, Grandis JR, Duvvuri U. PMID: 22954701.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    127. Carfilzomib and ONX 0912 inhibit cell survival and tumor growth of head and neck cancer and their activities are enhanced by suppression of Mcl-1 or autophagy. Clin Cancer Res. 2012 Oct 15; 18(20):5639-49. Zang Y, Thomas SM, Chan ET, Kirk CJ, Freilino ML, DeLancey HM, Grandis JR, Li C, Johnson DE. PMID: 22929803.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    128. Cetuximab and bevacizumab: preclinical data and phase II trial in recurrent or metastatic squamous cell carcinoma of the head and neck. Ann Oncol. 2013 Jan; 24(1):220-5. Argiris A, Kotsakis AP, Hoang T, Worden FP, Savvides P, Gibson MK, Gyanchandani R, Blumenschein GR, Chen HX, Grandis JR, Harari PM, Kies MS, Kim S. PMID: 22898037.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansCTClinical Trials
    129. Preclinical modeling of EGFR inhibitor resistance in head and neck cancer. Cancer Biol Ther. 2012 Aug; 13(10):935-45. Quesnelle KM, Wheeler SE, Ratay MK, Grandis JR. PMID: 22785204.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    130. Targeting Stat3 abrogates EGFR inhibitor resistance in cancer. Clin Cancer Res. 2012 Sep 15; 18(18):4986-96. Sen M, Joyce S, Panahandeh M, Li C, Thomas SM, Maxwell J, Wang L, Gooding WE, Johnson DE, Grandis JR. PMID: 22825581.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    131. Molecular pathways: context-dependent approaches to Notch targeting as cancer therapy. Clin Cancer Res. 2012 Oct 01; 18(19):5188-95. Egloff AM, Grandis JR. PMID: 22773520.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    132. Primary chemotherapy and radiation as a treatment strategy for HPV-positive oropharyngeal cancer. Head Neck Pathol. 2012 Jul; 6 Suppl 1:S91-7. Lui VW, Grandis JR. PMID: 22782228.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    133. Serum biomarker modulation following molecular targeting of epidermal growth factor and cyclooxygenase pathways: a pilot randomized trial in head and neck cancer. Oral Oncol. 2012 Nov; 48(11):1136-45. Moskowitz HS, Gooding WE, Thomas SM, Freilino ML, Gross N, Argiris A, Grandis JR, Ferris RL. PMID: 22732263.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    134. First-in-human trial of a STAT3 decoy oligonucleotide in head and neck tumors: implications for cancer therapy. Cancer Discov. 2012 Aug; 2(8):694-705. Sen M, Thomas SM, Kim S, Yeh JI, Ferris RL, Johnson JT, Duvvuri U, Lee J, Sahu N, Joyce S, Freilino ML, Shi H, Li C, Ly D, Rapireddy S, Etter JP, Li PK, Wang L, Chiosea S, Seethala RR, Gooding WE, Chen X, Kaminski N, Pandit K, Johnson DE, Grandis JR. PMID: 22719020.
      View in: PubMed   Mentions: 100     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    135. TMEM16A induces MAPK and contributes directly to tumorigenesis and cancer progression. Cancer Res. 2012 Jul 01; 72(13):3270-81. Duvvuri U, Shiwarski DJ, Xiao D, Bertrand C, Huang X, Edinger RS, Rock JR, Harfe BD, Henson BJ, Kunzelmann K, Schreiber R, Seethala RS, Egloff AM, Chen X, Lui VW, Grandis JR, Gollin SM. PMID: 22564524.
      View in: PubMed   Mentions: 90     Fields:    Translation:HumansAnimalsCells
    136. Lyn kinase mediates cell motility and tumor growth in EGFRvIII-expressing head and neck cancer. Clin Cancer Res. 2012 May 15; 18(10):2850-60. Wheeler SE, Morariu EM, Bednash JS, Otte CG, Seethala RR, Chiosea SI, Grandis JR. PMID: 22490227.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    137. Antitumor mechanisms of targeting the PDK1 pathway in head and neck cancer. Mol Cancer Ther. 2012 Jun; 11(6):1236-46. Bhola NE, Freilino ML, Joyce SC, Sen M, Thomas SM, Sahu A, Cassell A, Chen CS, Grandis JR. PMID: 22491800.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    138. Elevated gastrin-releasing peptide receptor mRNA expression in buccal mucosa: association with head and neck squamous cell carcinoma. Head Neck. 2013 Feb; 35(2):270-9. Egloff AM, Liu X, Davis AL, Trevelline BK, Vuga M, Siegfried JM, Grandis JR. PMID: 22431275.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    139. Tumor epidermal growth factor receptor and EGFR PY1068 are independent prognostic indicators for head and neck squamous cell carcinoma. Clin Cancer Res. 2012 Apr 15; 18(8):2278-89. Wheeler S, Siwak DR, Chai R, LaValle C, Seethala RR, Wang L, Cieply K, Sherer C, Joy C, Mills GB, Argiris A, Siegfried JM, Grandis JR, Egloff AM. PMID: 22351687.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    140. Antitumor effect of vandetanib through EGFR inhibition in head and neck squamous cell carcinoma. Head Neck. 2012 Sep; 34(9):1269-76. Klein JD, Christopoulos A, Ahn SM, Gooding WE, Grandis JR, Kim S. PMID: 22307735.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    141. Gastrin-releasing peptide receptor expression in non-cancerous bronchial epithelia is associated with lung cancer: a case-control study. Respir Res. 2012 Feb 01; 13:9. Egloff AM, Gaither Davis A, Shuai Y, Land S, Pilewski JM, Luketich JD, Landreneau R, Miller YE, Grandis JR, Siegfried JM. PMID: 22296774.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    142. Screening for head and neck cancer in liver transplant candidates: a review of 11 years of experience at the University of Pittsburgh. Laryngoscope. 2012 Mar; 122(3):539-42. Dedhia RC, Grandis JR, Fontes PA, Johnson JT, Weissfeld J. PMID: 22183711.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansPHPublic Health
    143. Effects of ERCC2 Lys751Gln (A35931C) and CCND1 (G870A) polymorphism on outcome of advanced-stage squamous cell carcinoma of the head and neck are treatment dependent. Cancer Epidemiol Biomarkers Prev. 2011 Nov; 20(11):2429-37. Zhong S, Nukui T, Buch S, Diergaarde B, Weissfeld LA, Grandis J, Romkes M, Weissfeld JL. PMID: 21890746.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    144. Serum biomarkers as potential predictors of antitumor activity of cetuximab-containing therapy for locally advanced head and neck cancer. Oral Oncol. 2011 Oct; 47(10):961-6. Argiris A, Lee SC, Feinstein T, Thomas S, Branstetter BF, Seethala R, Wang L, Gooding W, Grandis JR, Ferris RL. PMID: 21889392.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCTClinical Trials
    145. Phase I and pharmacokinetic study of dasatinib and cetuximab in patients with advanced solid malignancies. Invest New Drugs. 2012 Aug; 30(4):1575-84. Argiris A, Feinstein TM, Wang L, Yang T, Agrawal S, Appleman LJ, Stoller RG, Grandis JR, Egloff AM. PMID: 21881918.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCTClinical Trials
    146. Assembly and initial characterization of a panel of 85 genomically validated cell lines from diverse head and neck tumor sites. Clin Cancer Res. 2011 Dec 01; 17(23):7248-64. Zhao M, Sano D, Pickering CR, Jasser SA, Henderson YC, Clayman GL, Sturgis EM, Ow TJ, Lotan R, Carey TE, Sacks PG, Grandis JR, Sidransky D, Heldin NE, Myers JN. PMID: 21868764.
      View in: PubMed   Mentions: 97     Fields:    Translation:HumansCells
    147. Targeting mesenchymal exaptation to mitigate tumor growth. Cell Cycle. 2011 Aug 15; 10(16):2626-7. Thomas SM, Grandis JR. PMID: 21836394.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    148. The impact of tumor volume and radiotherapy dose on outcome in previously irradiated recurrent squamous cell carcinoma of the head and neck treated with stereotactic body radiation therapy. Am J Clin Oncol. 2011 Aug; 34(4):372-9. Rwigema JC, Heron DE, Ferris RL, Andrade RS, Gibson MK, Yang Y, Ozhasoglu C, Argiris AE, Grandis JR, Burton SA. PMID: 20859194.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    149. New advances in molecular approaches to head and neck squamous cell carcinoma. Anticancer Drugs. 2011 Aug; 22(7):656-64. Sahu N, Grandis JR. PMID: 21178766.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    150. The mutational landscape of head and neck squamous cell carcinoma. Science. 2011 Aug 26; 333(6046):1157-60. Stransky N, Egloff AM, Tward AD, Kostic AD, Cibulskis K, Sivachenko A, Kryukov GV, Lawrence MS, Sougnez C, McKenna A, Shefler E, Ramos AH, Stojanov P, Carter SL, Voet D, Cortés ML, Auclair D, Berger MF, Saksena G, Guiducci C, Onofrio RC, Parkin M, Romkes M, Weissfeld JL, Seethala RR, Wang L, Rangel-Escareño C, Fernandez-Lopez JC, Hidalgo-Miranda A, Melendez-Zajgla J, Winckler W, Ardlie K, Gabriel SB, Meyerson M, Lander ES, Getz G, Golub TR, Garraway LA, Grandis JR. PMID: 21798893.
      View in: PubMed   Mentions: 818     Fields:    Translation:HumansAnimalsCells
    151. Dual kinase inhibition of EGFR and HER2 overcomes resistance to cetuximab in a novel in vivo model of acquired cetuximab resistance. Clin Cancer Res. 2011 Sep 15; 17(18):5935-44. Quesnelle KM, Grandis JR. PMID: 21791633.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    152. Female hormonal and reproductive factors and head and neck squamous cell carcinoma risk. Cancer Lett. 2011 Nov 28; 310(2):216-21. Langevin SM, Grandis JR, Taioli E. PMID: 21802839.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    153. Radiation Resistance in Cancer Therapy: Meeting Summary and Research Opportunities: Report of an NCI Workshop held September 1-3, 2010. Radiat Res. 2011 Jul 08. Glazer PM, Grandis J, Powell SN, Brown JM, Helleday T, Bristow R, Powis G, Hill RP, Le QT, Pelroy R, Mohla S, Bernhard EJ. PMID: 21740251.
      View in: PubMed   Mentions:    Fields:    
    154. Radiation Resistance in Cancer Therapy: meeting summary and research opportunities. Report of an NCI Workshop held September 1-3, 2010. Radiat Res. 2011 Sep; 176(3):e0016-21. Glazer PM, Grandis J, Powell SN, Brown JM, Helleday T, Bristow R, Powis G, Hill RP, Le QT, Pelroy R, Mohla S, Bernhard EJ. PMID: 21867428.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    155. XPF expression correlates with clinical outcome in squamous cell carcinoma of the head and neck. Clin Cancer Res. 2011 Aug 15; 17(16):5513-22. Vaezi A, Wang X, Buch S, Gooding W, Wang L, Seethala RR, Weaver DT, D'Andrea AD, Argiris A, Romkes M, Niedernhofer LJ, Grandis JR. PMID: 21737503.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    156. Targeting GPCR-mediated p70S6K activity may improve head and neck cancer response to cetuximab. Clin Cancer Res. 2011 Aug 01; 17(15):4996-5004. Bhola NE, Thomas SM, Freilino M, Joyce S, Sahu A, Maxwell J, Argiris A, Seethala R, Grandis JR. PMID: 21653688.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    157. Dual blockade of EGFR and c-Met abrogates redundant signaling and proliferation in head and neck carcinoma cells. Clin Cancer Res. 2011 Jul 01; 17(13):4425-38. Xu H, Stabile LP, Gubish CT, Gooding WE, Grandis JR, Siegfried JM. PMID: 21622718.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    158. Phase I trial of pemetrexed in combination with cetuximab and concurrent radiotherapy in patients with head and neck cancer. Ann Oncol. 2011 Nov; 22(11):2482-8. Argiris A, Karamouzis MV, Smith R, Kotsakis A, Gibson MK, Lai SY, Kim S, Branstetter BF, Shuai Y, Romkes M, Wang L, Grandis JR, Ferris RL, Johnson JT, Heron DE. PMID: 21363880.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCTClinical Trials
    159. Sequential activation of inflammatory signaling pathways during graft-versus-host disease (GVHD): early role for STAT1 and STAT3. Cell Immunol. 2011; 268(1):37-46. Ma HH, Ziegler J, Li C, Sepulveda A, Bedeir A, Grandis J, Lentzsch S, Mapara MY. PMID: 21376308.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    160. STAT3 signaling: anticancer strategies and challenges. Mol Interv. 2011 Feb; 11(1):18-26. Johnston PA, Grandis JR. PMID: 21441118.
      View in: PubMed   Mentions: 106     Fields:    Translation:HumansCells
    161. Prognostic factors in patients with high-risk locally advanced salivary gland cancers treated with surgery and postoperative radiotherapy. Head Neck. 2011 Mar; 33(3):318-23. Feinstein TM, Lai SY, Lenzner D, Gooding W, Ferris RL, Grandis JR, Myers EN, Johnson JT, Heron DE, Argiris A. PMID: 21284048.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    162. Response to combined molecular targeting: defining the role of P-STAT3. Clin Cancer Res. 2011 Feb 01; 17(3):393-5. Egloff AM, Grandis JR. PMID: 21266530.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    163. Inhibition of EGFR-STAT3 signaling with erlotinib prevents carcinogenesis in a chemically-induced mouse model of oral squamous cell carcinoma. Cancer Prev Res (Phila). 2011 Feb; 4(2):230-7. Leeman-Neill RJ, Seethala RR, Singh SV, Freilino ML, Bednash JS, Thomas SM, Panahandeh MC, Gooding WE, Joyce SC, Lingen MW, Neill DB, Grandis JR. PMID: 21163936.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    164. Induction docetaxel, cisplatin, and cetuximab followed by concurrent radiotherapy, cisplatin, and cetuximab and maintenance cetuximab in patients with locally advanced head and neck cancer. J Clin Oncol. 2010 Dec 20; 28(36):5294-300. Argiris A, Heron DE, Smith RP, Kim S, Gibson MK, Lai SY, Branstetter BF, Posluszny DM, Wang L, Seethala RR, Dacic S, Gooding W, Grandis JR, Johnson JT, Ferris RL. PMID: 21079141.
      View in: PubMed   Mentions: 41     Fields:    Translation:Humans
    165. Combined analysis of estrogen receptor beta-1 and progesterone receptor expression identifies lung cancer patients with poor outcome. Clin Cancer Res. 2011 Jan 01; 17(1):154-64. Stabile LP, Dacic S, Land SR, Lenzner DE, Dhir R, Acquafondata M, Landreneau RJ, Grandis JR, Siegfried JM. PMID: 21062926.
      View in: PubMed   Mentions: 54     Fields:    Translation:Humans
    166. MicroRNA-137 promoter methylation is associated with poorer overall survival in patients with squamous cell carcinoma of the head and neck. Cancer. 2011 Apr 01; 117(7):1454-62. Langevin SM, Stone RA, Bunker CH, Lyons-Weiler MA, LaFramboise WA, Kelly L, Seethala RR, Grandis JR, Sobol RW, Taioli E. PMID: 21425146.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    167. Determinants of head and neck cancer survival by race. Head Neck. 2011 Aug; 33(8):1092-8. Ragin CC, Langevin SM, Marzouk M, Grandis J, Taioli E. PMID: 20967872.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    168. Epidermal growth factor receptor targeted therapy of squamous cell carcinoma of the head and neck. Head Neck. 2010 Oct; 32(10):1412-21. Sharafinski ME, Ferris RL, Ferrone S, Grandis JR. PMID: 20848399.
      View in: PubMed   Mentions: 47     Fields:    Translation:Humans
    169. Human papillomavirus and head and neck cancer. Oncology (Williston Park). 2010 Sep; 24(10):927, 933. Diergaarde B, Grandis JR. PMID: 21138174.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    170. Emerging drugs to treat squamous cell carcinomas of the head and neck. Expert Opin Emerg Drugs. 2010 Sep; 15(3):355-73. Fung C, Grandis JR. PMID: 20557270.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimals
    171. Epidermal growth factor receptor variant III mediates head and neck cancer cell invasion via STAT3 activation. Oncogene. 2010 Sep 16; 29(37):5135-45. Wheeler SE, Suzuki S, Thomas SM, Sen M, Leeman-Neill RJ, Chiosea SI, Kuan CT, Bigner DD, Gooding WE, Lai SY, Grandis JR. PMID: 20622897.
      View in: PubMed   Mentions: 40     Fields:    Translation:Humans
    172. Molecular analysis of plasma DNA for the early detection of lung cancer by quantitative methylation-specific PCR. Clin Cancer Res. 2010 Jul 01; 16(13):3463-72. Ostrow KL, Hoque MO, Loyo M, Brait M, Greenberg A, Siegfried JM, Grandis JR, Gaither Davis A, Bigbee WL, Rom W, Sidransky D. PMID: 20592015.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    173. Epidermal growth factor receptor expression and gene copy number in the risk of oral cancer. Cancer Prev Res (Phila). 2010 Jul; 3(7):800-9. Taoudi Benchekroun M, Saintigny P, Thomas SM, El-Naggar AK, Papadimitrakopoulou V, Ren H, Lang W, Fan YH, Huang J, Feng L, Lee JJ, Kim ES, Hong WK, Johnson FM, Grandis JR, Mao L. PMID: 20570883.
      View in: PubMed   Mentions: 27     Fields:    Translation:Humans
    174. Quantitative proteomics analysis reveals molecular networks regulated by epidermal growth factor receptor level in head and neck cancer. J Proteome Res. 2010 Jun 04; 9(6):3073-82. Yang W, Cai Q, Lui VW, Everley PA, Kim J, Bhola N, Quesnelle KM, Zetter BR, Steen H, Freeman MR, Grandis JR. PMID: 20426488.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    175. Investigational EGFR-targeted therapy in head and neck squamous cell carcinoma. Expert Opin Investig Drugs. 2010 Jun; 19(6):709-22. Cassell A, Grandis JR. PMID: 20415598.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimals
    176. Response assessment by combined PET-CT scan versus CT scan alone using RECIST in patients with locally advanced head and neck cancer treated with chemoradiotherapy. Ann Oncol. 2010 Nov; 21(11):2278-83. Passero VA, Branstetter BF, Shuai Y, Heron DE, Gibson MK, Lai SY, Kim SW, Grandis JR, Ferris RL, Johnson JT, Argiris A. PMID: 20430907.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    177. New strategies in head and neck cancer: understanding resistance to epidermal growth factor receptor inhibitors. Clin Cancer Res. 2010 May 01; 16(9):2489-95. Chen LF, Cohen EE, Grandis JR. PMID: 20406834.
      View in: PubMed   Mentions: 33     Fields:    Translation:Humans
    178. Honokiol inhibits epidermal growth factor receptor signaling and enhances the antitumor effects of epidermal growth factor receptor inhibitors. Clin Cancer Res. 2010 May 01; 16(9):2571-9. Leeman-Neill RJ, Cai Q, Joyce SC, Thomas SM, Bhola NE, Neill DB, Arbiser JL, Grandis JR. PMID: 20388852.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    179. Nuclear localization of signal transducer and activator of transcription 3 in head and neck squamous cell carcinoma is associated with a better prognosis. Clin Cancer Res. 2010 Apr 15; 16(8):2427-34. Pectasides E, Egloff AM, Sasaki C, Kountourakis P, Burtness B, Fountzilas G, Dafni U, Zaramboukas T, Rampias T, Rimm D, Grandis J, Psyrri A. PMID: 20371693.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    180. MicroRNA-137 promoter methylation in oral rinses from patients with squamous cell carcinoma of the head and neck is associated with gender and body mass index. Carcinogenesis. 2010 May; 31(5):864-70. Langevin SM, Stone RA, Bunker CH, Grandis JR, Sobol RW, Taioli E. PMID: 20197299.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansCells
    181. The impact of health insurance status on the survival of patients with head and neck cancer. Cancer. 2010 Jan 15; 116(2):476-85. Kwok J, Langevin SM, Argiris A, Grandis JR, Gooding WE, Taioli E. PMID: 19937673.
      View in: PubMed   Mentions: 43     Fields:    Translation:Humans
    182. The molecular pathogenesis of head and neck cancer. Cancer Biol Ther. 2010 Jan; 9(1):1-7. Klein JD, Grandis JR. PMID: 20038820.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    183. Molecular changes in the multistage pathogenesis of head and neck cancer. Cancer Biomark. 2010; 9(1-6):325-39. Park BJ, Chiosea SI, Grandis JR. PMID: 22112483.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    184. Management of patients treated with chemoradiotherapy for head and neck cancer without prophylactic feeding tubes: the University of Pittsburgh experience. Laryngoscope. 2010 Jan; 120(1):71-5. McLaughlin BT, Gokhale AS, Shuai Y, Diacopoulos J, Carrau R, Heron DE, Smith RP, Gibson MK, Ferris RL, Grandis JR, Johnson JT, Argiris A. PMID: 19877245.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    185. The current state of head and neck cancer gene therapy. Hum Gene Ther. 2009 Dec; 20(12):1565-75. Thomas SM, Grandis JR. PMID: 19747066.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    186. Systematic prediction of human membrane receptor interactions. Proteomics. 2009 Dec; 9(23):5243-55. Qi Y, Dhiman HK, Bhola N, Budyak I, Kar S, Man D, Dutta A, Tirupula K, Carr BI, Grandis J, Bar-Joseph Z, Klein-Seetharaman J. PMID: 19798668.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    187. An informatics supported web-based data annotation and query tool to expedite translational research for head and neck malignancies. BMC Cancer. 2009 Nov 13; 9:396. Amin W, Kang HP, Egloff AM, Singh H, Trent K, Ridge-Hetrick J, Seethala RR, Grandis J, Parwani AV. PMID: 19912644.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    188. STAT3 activation contributes directly to Epstein-Barr virus-mediated invasiveness of nasopharyngeal cancer cells in vitro. Int J Cancer. 2009 Oct 15; 125(8):1884-93. Lui VW, Wong EY, Ho Y, Hong B, Wong SC, Tao Q, Choi GC, Au TC, Ho K, Yau DM, Ma BB, Hui EP, Chan AS, Tsang CM, Tsao SW, Grandis JR, Chan AT. PMID: 19588483.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    189. Cross-talk between estrogen receptor and epidermal growth factor receptor in head and neck squamous cell carcinoma. Clin Cancer Res. 2009 Nov 01; 15(21):6529-40. Egloff AM, Rothstein ME, Seethala R, Siegfried JM, Grandis JR, Stabile LP. PMID: 19825947.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    190. Guggulsterone enhances head and neck cancer therapies via inhibition of signal transducer and activator of transcription-3. Carcinogenesis. 2009 Nov; 30(11):1848-56. Leeman-Neill RJ, Wheeler SE, Singh SV, Thomas SM, Seethala RR, Neill DB, Panahandeh MC, Hahm ER, Joyce SC, Sen M, Cai Q, Freilino ML, Li C, Johnson DE, Grandis JR. PMID: 19762335.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    191. Bortezomib up-regulates activated signal transducer and activator of transcription-3 and synergizes with inhibitors of signal transducer and activator of transcription-3 to promote head and neck squamous cell carcinoma cell death. Mol Cancer Ther. 2009 Aug; 8(8):2211-20. Li C, Zang Y, Sen M, Leeman-Neill RJ, Man DS, Grandis JR, Johnson DE. PMID: 19638453.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    192. Improving Response Rates to EGFR-Targeted Therapies for Head and Neck Squamous Cell Carcinoma: Candidate Predictive Biomarkers and Combination Treatment with Src Inhibitors. J Oncol. 2009; 2009:896407. Egloff AM, Grandis JR. PMID: 19636423.
      View in: PubMed   Mentions:
    193. HGF and c-Met participate in paracrine tumorigenic pathways in head and neck squamous cell cancer. Clin Cancer Res. 2009 Jun 01; 15(11):3740-50. Knowles LM, Stabile LP, Egloff AM, Rothstein ME, Thomas SM, Gubish CT, Lerner EC, Seethala RR, Suzuki S, Quesnelle KM, Morgan S, Ferris RL, Grandis JR, Siegfried JM. PMID: 19470725.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansAnimalsCells
    194. Stereotactic body radiotherapy for recurrent squamous cell carcinoma of the head and neck: results of a phase I dose-escalation trial. Int J Radiat Oncol Biol Phys. 2009 Dec 01; 75(5):1493-500. Heron DE, Ferris RL, Karamouzis M, Andrade RS, Deeb EL, Burton S, Gooding WE, Branstetter BF, Mountz JM, Johnson JT, Argiris A, Grandis JR, Lai SY. PMID: 19464819.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansPHPublic HealthCTClinical Trials
    195. PUMA mediates EGFR tyrosine kinase inhibitor-induced apoptosis in head and neck cancer cells. Oncogene. 2009 Jun 18; 28(24):2348-57. Sun Q, Ming L, Thomas SM, Wang Y, Chen ZG, Ferris RL, Grandis JR, Zhang L, Yu J. PMID: 19421143.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    196. Targeting angiogenesis from premalignancy to metastases. Cancer Prev Res (Phila). 2009 Apr; 2(4):291-4. Grandis JR, Argiris A. PMID: 19336719.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    197. Role of polymorphic Fc gamma receptor IIIa and EGFR expression level in cetuximab mediated, NK cell dependent in vitro cytotoxicity of head and neck squamous cell carcinoma cells. Cancer Immunol Immunother. 2009 Nov; 58(11):1853-64. López-Albaitero A, Lee SC, Morgan S, Grandis JR, Gooding WE, Ferrone S, Ferris RL. PMID: 19319529.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansCells
    198. ABT-737 synergizes with chemotherapy to kill head and neck squamous cell carcinoma cells via a Noxa-mediated pathway. Mol Pharmacol. 2009 May; 75(5):1231-9. Li R, Zang Y, Li C, Patel NS, Grandis JR, Johnson DE. PMID: 19246337.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    199. Intratumoral epidermal growth factor receptor antisense DNA therapy in head and neck cancer: first human application and potential antitumor mechanisms. J Clin Oncol. 2009 Mar 10; 27(8):1235-42. Lai SY, Koppikar P, Thomas SM, Childs EE, Egloff AM, Seethala RR, Branstetter BF, Gooding WE, Muthukrishnan A, Mountz JM, Lui VW, Shin DM, Agarwala SS, Johnson R, Couture LA, Myers EN, Johnson JT, Mills G, Argiris A, Grandis JR. PMID: 19204206.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCTClinical Trials
    200. Molecular target approaches in head and neck cancer: epidermal growth factor receptor and beyond. Semin Radiat Oncol. 2009 Jan; 19(1):63-8. Harari PM, Wheeler DL, Grandis JR. PMID: 19028347.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    201. Constitutive activation of signal transducer and activator of transcription 5 contributes to tumor growth, epithelial-mesenchymal transition, and resistance to epidermal growth factor receptor targeting. Clin Cancer Res. 2008 Dec 01; 14(23):7682-90. Koppikar P, Lui VW, Man D, Xi S, Chai RL, Nelson E, Tobey AB, Grandis JR. PMID: 19047094.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    202. Kinin b2 receptor mediates induction of cyclooxygenase-2 and is overexpressed in head and neck squamous cell carcinomas. Mol Cancer Res. 2008 Dec; 6(12):1946-56. Zhang W, Bhola N, Kalyankrishna S, Gooding W, Hunt J, Seethala R, Grandis JR, Siegfried JM. PMID: 19074839.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    203. Genetic screening for oral human papillomavirus infections and cancers of the head and neck. Clin Cancer Res. 2008 Nov 01; 14(21):6723-4. Sok JC, Grandis JR. PMID: 18980962.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    204. Human rhomboid family-1 gene RHBDF1 participates in GPCR-mediated transactivation of EGFR growth signals in head and neck squamous cancer cells. FASEB J. 2009 Feb; 23(2):425-32. Zou H, Thomas SM, Yan ZW, Grandis JR, Vogt A, Li LY. PMID: 18832597.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    205. Lack of toxicity of a STAT3 decoy oligonucleotide. Cancer Chemother Pharmacol. 2009 May; 63(6):983-95. Sen M, Tosca PJ, Zwayer C, Ryan MJ, Johnson JD, Knostman KA, Giclas PC, Peggins JO, Tomaszewski JE, McMurray TP, Li C, Leibowitz MS, Ferris RL, Gooding WE, Thomas SM, Johnson DE, Grandis JR. PMID: 18766340.
      View in: PubMed   Mentions: 22     Fields:    Translation:Animals
    206. ErbB receptors in the biology and pathology of the aerodigestive tract. Exp Cell Res. 2009 Feb 15; 315(4):572-82. Morgan S, Grandis JR. PMID: 18778701.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    207. Resveratrol causes COX-2- and p53-dependent apoptosis in head and neck squamous cell cancer cells. J Cell Biochem. 2008 Aug 15; 104(6):2131-42. Lin HY, Sun M, Tang HY, Simone TM, Wu YH, Grandis JR, Cao HJ, Davis PJ, Davis FB. PMID: 18446786.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    208. Combined inhibition of c-Src and epidermal growth factor receptor abrogates growth and invasion of head and neck squamous cell carcinoma. Clin Cancer Res. 2008 Jul 01; 14(13):4284-91. Koppikar P, Choi SH, Egloff AM, Cai Q, Suzuki S, Freilino M, Nozawa H, Thomas SM, Gooding WE, Siegfried JM, Grandis JR. PMID: 18594011.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansCells
    209. Combined inhibition of PLC{gamma}-1 and c-Src abrogates epidermal growth factor receptor-mediated head and neck squamous cell carcinoma invasion. Clin Cancer Res. 2008 Jul 01; 14(13):4336-44. Nozawa H, Howell G, Suzuki S, Zhang Q, Qi Y, Klein-Seetharaman J, Wells A, Grandis JR, Thomas SM. PMID: 18594017.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    210. Human rhomboid family-1 gene silencing causes apoptosis or autophagy to epithelial cancer cells and inhibits xenograft tumor growth. Mol Cancer Ther. 2008 Jun; 7(6):1355-64. Yan Z, Zou H, Tian F, Grandis JR, Mixson AJ, Lu PY, Li LY. PMID: 18524845.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    211. Introduction: head and neck cancer. Semin Oncol. 2008 Jun; 35(3):196-7. Vokes EE, Cohen EE, Grandis JR. PMID: 18544434.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    212. Targeting epidermal growth factor receptor and SRC pathways in head and neck cancer. Semin Oncol. 2008 Jun; 35(3):286-97. Egloff AM, Grandis JR. PMID: 18544443.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    213. Bortezomib induces apoptosis via Bim and Bik up-regulation and synergizes with cisplatin in the killing of head and neck squamous cell carcinoma cells. Mol Cancer Ther. 2008 Jun; 7(6):1647-55. Li C, Li R, Grandis JR, Johnson DE. PMID: 18566236.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    214. Emerging perspectives in epidermal growth factor receptor targeting in head and neck cancer. Head Neck. 2008 May; 30(5):667-74. Kim S, Grandis JR, Rinaldo A, Takes RP, Ferlito A. PMID: 18383530.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    215. Combined targeting of epidermal growth factor receptor, signal transducer and activator of transcription-3, and Bcl-X(L) enhances antitumor effects in squamous cell carcinoma of the head and neck. Mol Pharmacol. 2008 Jun; 73(6):1632-42. Boehm AL, Sen M, Seethala R, Gooding WE, Freilino M, Wong SM, Wang S, Johnson DE, Grandis JR. PMID: 18326051.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    216. Immunohistochemical analysis of phosphotyrosine signal transducer and activator of transcription 3 and epidermal growth factor receptor autocrine signaling pathways in head and neck cancers and metastatic lymph nodes. Clin Cancer Res. 2008 Mar 01; 14(5):1303-9. Seethala RR, Gooding WE, Handler PN, Collins B, Zhang Q, Siegfried JM, Grandis JR. PMID: 18316548.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    217. Long-term results of a phase III randomized trial of postoperative radiotherapy with or without carboplatin in patients with high-risk head and neck cancer. Laryngoscope. 2008 Mar; 118(3):444-9. Argiris A, Karamouzis MV, Johnson JT, Heron DE, Myers E, Eibling D, Cano E, Urba S, Gluckman J, Grandis JR, Wang Y, Agarwala SS. PMID: 18091334.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCTClinical Trials
    218. Gefitinib potentiates myeloid cell differentiation by ATRA. Leukemia. 2008 Aug; 22(8):1624-7. Miranda MB, Duan R, Thomas SM, Grandis JR, Redner RL, Jones JE, Johnson DE. PMID: 18305561.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    219. Crosstalk between G-protein-coupled receptors and epidermal growth factor receptor in cancer. Front Biosci. 2008 Jan 01; 13:1857-65. Bhola NE, Grandis JR. PMID: 17981673.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    220. Clinical applications of gene therapy in head and neck cancer. Curr Gene Ther. 2007 Dec; 7(6):446-57. Karamouzis MV, Argiris A, Grandis JR. PMID: 18045104.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    221. Antitumor mechanisms of systemically administered epidermal growth factor receptor antisense oligonucleotides in combination with docetaxel in squamous cell carcinoma of the head and neck. Mol Pharmacol. 2008 Mar; 73(3):627-38. Thomas SM, Ogagan MJ, Freilino ML, Strychor S, Walsh DR, Gooding WE, Grandis JR, Zamboni WC. PMID: 18025070.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    222. NF-kappaB gene signatures and p53 mutations in head and neck squamous cell carcinoma. Clin Cancer Res. 2007 Oct 01; 13(19):5663-4. Ferris RL, Grandis JR. PMID: 17908953.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    223. Targeting antiapoptotic Bcl-2 family members with cell-permeable BH3 peptides induces apoptosis signaling and death in head and neck squamous cell carcinoma cells. Neoplasia. 2007 Oct; 9(10):801-11. Li R, Boehm AL, Miranda MB, Shangary S, Grandis JR, Johnson DE. PMID: 17971900.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    224. STAT-mediated EGFR signaling in cancer. J Cell Biochem. 2007 Oct 01; 102(2):311-9. Quesnelle KM, Boehm AL, Grandis JR. PMID: 17661350.
      View in: PubMed   Mentions: 94     Fields:    Translation:HumansAnimalsCells
    225. Advances and challenges in aerodigestive epithelial cancer: meeting summary and research opportunities. Cancer Res. 2007 Aug 15; 67(16):7556-8. Grandis JR, Carbone DP, Rustgi AK. PMID: 17686829.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    226. Therapies directed against epidermal growth factor receptor in aerodigestive carcinomas. JAMA. 2007 Jul 04; 298(1):70-82. Karamouzis MV, Grandis JR, Argiris A. PMID: 17609492.
      View in: PubMed   Mentions: 50     Fields:    Translation:Humans
    227. Aberrant kinase signaling: lessons from head and neck cancer. Future Oncol. 2007 Jun; 3(3):353-61. Nelson EG, Grandis JR. PMID: 17547530.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    228. Multiple cytokine and growth factor serum biomarkers predict therapeutic response and survival in advanced-stage head and neck cancer patients. Clin Cancer Res. 2007 Jun 01; 13(11):3107-8. Bigbee WL, Grandis JR, Siegfried JM. PMID: 17545511.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    229. Association of the EGFR intron 1 CA repeat length with lung cancer risk. Mol Carcinog. 2007 May; 46(5):372-80. Zhang W, Weissfeld JL, Romkes M, Land SR, Grandis JR, Siegfried JM. PMID: 17219440.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    230. Antitumor mechanisms of combined gastrin-releasing peptide receptor and epidermal growth factor receptor targeting in head and neck cancer. Mol Cancer Ther. 2007 Apr; 6(4):1414-24. Zhang Q, Bhola NE, Lui VW, Siwak DR, Thomas SM, Gubish CT, Siegfried JM, Mills GB, Shin D, Grandis JR. PMID: 17431120.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    231. Selective inhibition of ADAM metalloproteases as a novel approach for modulating ErbB pathways in cancer. Clin Cancer Res. 2007 Mar 15; 13(6):1892-902. Fridman JS, Caulder E, Hansbury M, Liu X, Yang G, Wang Q, Lo Y, Zhou BB, Pan M, Thomas SM, Grandis JR, Zhuo J, Yao W, Newton RC, Friedman SM, Scherle PA, Vaddi K. PMID: 17363546.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    232. Altered inflammatory gene expression underlies increased susceptibility to murine postoperative ileus with advancing age. Am J Physiol Gastrointest Liver Physiol. 2007 Jun; 292(6):G1650-9. Moore BA, Albers KM, Davis BM, Grandis JR, Tögel S, Bauer AJ. PMID: 17363464.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    233. Antiproliferative mechanisms of a transcription factor decoy targeting signal transducer and activator of transcription (STAT) 3: the role of STAT1. Mol Pharmacol. 2007 May; 71(5):1435-43. Lui VW, Boehm AL, Koppikar P, Leeman RJ, Johnson D, Ogagan M, Childs E, Freilino M, Grandis JR. PMID: 17325127.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    234. Gastrin-releasing peptide activates Akt through the epidermal growth factor receptor pathway and abrogates the effect of gefitinib. Exp Cell Res. 2007 Apr 15; 313(7):1361-72. Liu X, Carlisle DL, Swick MC, Gaither-Davis A, Grandis JR, Siegfried JM. PMID: 17349623.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    235. Head and neck squamous cell carcinoma cell lines: established models and rationale for selection. Head Neck. 2007 Feb; 29(2):163-88. Lin CJ, Grandis JR, Carey TE, Gollin SM, Whiteside TL, Koch WM, Ferris RL, Lai SY. PMID: 17312569.
      View in: PubMed   Mentions: 104     Fields:    Translation:HumansCells
    236. The role of CD44 in HNSCC. Cancer Biol Ther. 2007 Jan; 6(1):125-6. Nelson AD, Grandis JR. PMID: 17297303.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    237. Established and emerging concepts in epidermal growth factor receptor biology. Int J Radiat Oncol Biol Phys. 2007; 69(2 Suppl):S22-4. Grandis JR. PMID: 17848285.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    238. Cross-talk between G protein-coupled receptor and epidermal growth factor receptor signaling pathways contributes to growth and invasion of head and neck squamous cell carcinoma. Cancer Res. 2006 Dec 15; 66(24):11831-9. Thomas SM, Bhola NE, Zhang Q, Contrucci SC, Wentzel AL, Freilino ML, Gooding WE, Siegfried JM, Chan DC, Grandis JR. PMID: 17178880.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    239. Understanding the presence and function of erythropoietin receptors on cancer cells. J Clin Oncol. 2006 Oct 10; 24(29):4675-6. Lai SY, Grandis JR. PMID: 17028292.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    240. Epidermal growth factor receptor-targeted molecular therapeutics for head and neck squamous cell carcinoma. Expert Opin Ther Targets. 2006 Oct; 10(5):639-47. Egloff AM, Grandis J. PMID: 16981821.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    241. Frameless stereotactic radiosurgery for recurrent head and neck carcinoma. Technol Cancer Res Treat. 2006 Oct; 5(5):529-35. Voynov G, Heron DE, Burton S, Grandis J, Quinn A, Ferris R, Ozhasoglu C, Vogel W, Johnson J. PMID: 16981796.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    242. Importance of molecular analysis in detecting cervical lymph node metastasis in head and neck squamous cell carcinoma. Head Neck. 2006 Sep; 28(9):842-9. Elsheikh MN, Rinaldo A, Hamakawa H, Mahfouz ME, Rodrigo JP, Brennan J, Devaney KO, Grandis JR, Ferlito A. PMID: 16691557.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    243. Mutant epidermal growth factor receptor (EGFRvIII) contributes to head and neck cancer growth and resistance to EGFR targeting. Clin Cancer Res. 2006 Sep 01; 12(17):5064-73. Sok JC, Coppelli FM, Thomas SM, Lango MN, Xi S, Hunt JL, Freilino ML, Graner MW, Wikstrand CJ, Bigner DD, Gooding WE, Furnari FB, Grandis JR. PMID: 16951222.
      View in: PubMed   Mentions: 154     Fields:    Translation:HumansAnimalsCells
    244. Prognostic biomarkers in head and neck cancer. Clin Cancer Res. 2006 Sep 01; 12(17):5005-6. Grandis JR. PMID: 16951212.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    245. Mutation and polymorphism in the EGFR-TK domain associated with lung cancer. J Thorac Oncol. 2006 Sep; 1(7):635-47. Zhang W, Stabile LP, Keohavong P, Romkes M, Grandis JR, Traynor AM, Siegfried JM. PMID: 17409930.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    246. Research education and training in otolaryngology: meeting summary and research opportunities. Otolaryngol Head Neck Surg. 2006 Sep; 135(3):361-7. Grandis JR, Battey JF, Califf RM, Chole RA, Gantz BJ, Gates GA, Gorelic L, Hannley MT, Hardwick KS, Harris JP, Kapoor WN, Lai SY, Lalwani AK, Minor LB, Nadol JP, Post JC, Roland PS, Schechter AM, Schuller DE, Sklare DA, Wackym PA, Weber RS, Weymuller EA, Wolf GT, Woodson GE. PMID: 16949965.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    247. STAT3 is required but not sufficient for EGF receptor-mediated migration and invasion of human prostate carcinoma cell lines. Br J Cancer. 2006 Jul 17; 95(2):164-71. Zhou W, Grandis JR, Wells A. PMID: 16804520.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    248. Epidermal growth factor receptor biology in head and neck cancer. J Clin Oncol. 2006 Jun 10; 24(17):2666-72. Kalyankrishna S, Grandis JR. PMID: 16763281.
      View in: PubMed   Mentions: 196     Fields:    Translation:HumansCells
    249. Head and neck cancer: recent advances and new standards of care. J Clin Oncol. 2006 Jun 10; 24(17):2603-5. Forastiere AA, Trotti A, Pfister DG, Grandis JR. PMID: 16763271.
      View in: PubMed   Mentions: 25     Fields:    Translation:Humans
    250. Women in otolaryngology: closing the gender gap. Curr Opin Otolaryngol Head Neck Surg. 2006 Jun; 14(3):159-63. Ferguson BJ, Grandis JR. PMID: 16728893.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    251. Phosphorylation of TNF-alpha converting enzyme by gastrin-releasing peptide induces amphiregulin release and EGF receptor activation. Proc Natl Acad Sci U S A. 2006 May 02; 103(18):6901-6. Zhang Q, Thomas SM, Lui VW, Xi S, Siegfried JM, Fan H, Smithgall TE, Mills GB, Grandis JR. PMID: 16641105.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansCells
    252. STAT3 as a therapeutic target in head and neck cancer. Expert Opin Biol Ther. 2006 Mar; 6(3):231-41. Leeman RJ, Lui VW, Grandis JR. PMID: 16503733.
      View in: PubMed   Mentions: 89     Fields:    Translation:HumansAnimalsCells
    253. Decreased STAT1 expression by promoter methylation in squamous cell carcinogenesis. J Natl Cancer Inst. 2006 Feb 01; 98(3):181-9. Xi S, Dyer KF, Kimak M, Zhang Q, Gooding WE, Chaillet JR, Chai RL, Ferrell RE, Zamboni B, Hunt J, Grandis JR. PMID: 16449678.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    254. Advances in molecular diagnostics and therapeutics in head and neck cancer. Curr Treat Options Oncol. 2006 Jan; 7(1):3-11. Chai RL, Grandis JR. PMID: 16343364.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    255. Inhibition of insulin/IGF-1 receptor signaling enhances bile acid toxicity in primary hepatocytes. Biochem Pharmacol. 2005 Nov 25; 70(11):1685-96. Dent P, Han SI, Mitchell C, Studer E, Yacoub A, Grandis J, Grant S, Krystal GW, Hylemon PB. PMID: 16207485.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    256. Role of NQO1 polymorphisms as risk factors for squamous cell carcinoma of the head and neck. Oral Oncol. 2005 Oct; 41(9):927-33. Begleiter A, Norman A, Leitao D, Cabral T, Hewitt D, Pan S, Grandis JR, Siegfried JM, El-Sayed S, Sutherland D, Ross DA, Kerr PD. PMID: 16054862.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    257. Chemokine receptor 7 activates phosphoinositide-3 kinase-mediated invasive and prosurvival pathways in head and neck cancer cells independent of EGFR. Oncogene. 2005 Sep 01; 24(38):5897-904. Wang J, Zhang X, Thomas SM, Grandis JR, Wells A, Chen ZG, Ferris RL. PMID: 16007209.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    258. Molecular mediators of metastasis in head and neck squamous cell carcinoma. Head Neck. 2005 Aug; 27(8):710-7. Howell GM, Grandis JR. PMID: 15952195.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    259. Erythropoietin-mediated activation of JAK-STAT signaling contributes to cellular invasion in head and neck squamous cell carcinoma. Oncogene. 2005 Jun 23; 24(27):4442-9. Lai SY, Childs EE, Xi S, Coppelli FM, Gooding WE, Wells A, Ferris RL, Grandis JR. PMID: 15856028.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansCells
    260. Gastrin-releasing peptide receptor mediates activation of the epidermal growth factor receptor in lung cancer cells. Neoplasia. 2005 Apr; 7(4):426-31. Thomas SM, Grandis JR, Wentzel AL, Gooding WE, Lui VW, Siegfried JM. PMID: 15967120.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    261. Association of polymorphisms in the cyclin D1 and XPD genes and susceptibility to cancers of the upper aero-digestive tract. Mol Carcinog. 2005 Apr; 42(4):222-8. Buch S, Zhu B, Davis AG, Odom D, Siegfried JM, Grandis JR, Romkes M. PMID: 15754315.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    262. Multiplexed analysis of serum cytokines as biomarkers in squamous cell carcinoma of the head and neck patients. Laryngoscope. 2005 Mar; 115(3):522-7. Hathaway B, Landsittel DP, Gooding W, Whiteside TL, Grandis JR, Siegfried JM, Bigbee WL, Ferris RL. PMID: 15744170.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    263. Combined targeting of the estrogen receptor and the epidermal growth factor receptor in non-small cell lung cancer shows enhanced antiproliferative effects. Cancer Res. 2005 Feb 15; 65(4):1459-70. Stabile LP, Lyker JS, Gubish CT, Zhang W, Grandis JR, Siegfried JM. PMID: 15735034.
      View in: PubMed   Mentions: 99     Fields:    Translation:HumansAnimalsCells
    264. In vivo antitumor efficacy of STAT3 blockade using a transcription factor decoy approach: implications for cancer therapy. Oncogene. 2005 Feb 03; 24(6):970-9. Xi S, Gooding WE, Grandis JR. PMID: 15592503.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansAnimalsCells
    265. Antiangiogenic therapy of head and neck squamous cell carcinoma by vascular endothelial growth factor antisense therapy. Adv Otorhinolaryngol. 2005; 62:103-20. Riedel F, Götte K, Hörmann K, Grandis JR. PMID: 15608422.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    266. Oligonucleotides as anticancer agents: from the benchside to the clinic and beyond. Curr Pharm Des. 2005; 11(22):2825-40. Coppelli FM, Grandis JR. PMID: 16101440.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    267. The epidermal growth factor receptor signaling network in head and neck carcinogenesis and implications for targeted therapy. Semin Oncol. 2004 Dec; 31(6):734-43. Pomerantz RG, Grandis JR. PMID: 15599851.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    268. IL-12 receptor-mediated upregulation of FasL in human ovarian carcinoma cells. Int J Cancer. 2004 Nov 20; 112(4):620-7. Gorelik E, Edwards RP, Feng X, Marrangoni AM, Grandis JR, Drenning SD, Velikokhatnaya L, Kwon JA, Lokshin AE. PMID: 15382042.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    269. Head and neck cancer: meeting summary and research opportunities. Cancer Res. 2004 Nov 01; 64(21):8126-9. Grandis JR, Pietenpol JA, Greenberger JS, Pelroy RA, Mohla S. PMID: 15520225.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    270. Abrogation of head and neck squamous cell carcinoma growth by epidermal growth factor receptor ligand fused to pseudomonas exotoxin transforming growth factor alpha-PE38. Clin Cancer Res. 2004 Oct 15; 10(20):7079-87. Thomas SM, Zeng Q, Epperly MW, Gooding WE, Pastan I, Wang QC, Greenberger J, Grandis JR. PMID: 15501988.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    271. Mutation of p53 in head and neck squamous cell carcinoma correlates with Bcl-2 expression and increased susceptibility to cisplatin-induced apoptosis. Head Neck. 2004 Oct; 26(10):870-7. Andrews GA, Xi S, Pomerantz RG, Lin CJ, Gooding WE, Wentzel AL, Wu L, Sidransky D, Grandis JR. PMID: 15390206.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    272. SRC family kinases mediate epidermal growth factor receptor ligand cleavage, proliferation, and invasion of head and neck cancer cells. Cancer Res. 2004 Sep 01; 64(17):6166-73. Zhang Q, Thomas SM, Xi S, Smithgall TE, Siegfried JM, Kamens J, Gooding WE, Grandis JR. PMID: 15342401.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansCells
    273. Simultaneously targeting epidermal growth factor receptor tyrosine kinase and cyclooxygenase-2, an efficient approach to inhibition of squamous cell carcinoma of the head and neck. Clin Cancer Res. 2004 Sep 01; 10(17):5930-9. Chen Z, Zhang X, Li M, Wang Z, Wieand HS, Grandis JR, Shin DM. PMID: 15355926.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansCells
    274. The gender gap in a surgical subspecialty: analysis of career and lifestyle factors. Arch Otolaryngol Head Neck Surg. 2004 Jun; 130(6):695-702. Grandis JR, Gooding WE, Zamboni BA, Wagener MM, Drenning SD, Miller L, Doyle KJ, Mackinnon SE, Wagner RL. PMID: 15210549.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    275. Pharmacokinetic and pharmacodynamic properties of EGFR inhibitors under clinical investigation. Cancer Treat Rev. 2004 May; 30(3):255-68. Thomas SM, Grandis JR. PMID: 15059649.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimals
    276. Signaling through the epidermal growth factor receptor during the development of malignancy. Pharmacol Ther. 2004 Apr; 102(1):37-46. Grandis JR, Sok JC. PMID: 15056497.
      View in: PubMed   Mentions: 92     Fields:    Translation:HumansAnimalsCells
    277. Selective jejunal manipulation causes postoperative pan-enteric inflammation and dysmotility. Gastroenterology. 2004 Jan; 126(1):159-69. Schwarz NT, Kalff JC, Türler A, Speidel N, Grandis JR, Billiar TR, Bauer AJ. PMID: 14699497.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    278. Constitutive activation of Stat5b contributes to carcinogenesis in vivo. Cancer Res. 2003 Oct 15; 63(20):6763-71. Xi S, Zhang Q, Gooding WE, Smithgall TE, Grandis JR. PMID: 14583472.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    279. Antitumor effects of epidermal growth factor receptor antisense oligonucleotides in combination with docetaxel in squamous cell carcinoma of the head and neck. Clin Cancer Res. 2003 Oct 15; 9(13):5028-35. Niwa H, Wentzel AL, Li M, Gooding WE, Lui VW, Grandis JR. PMID: 14581378.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    280. Tyrphostin AG 126 inhibits development of postoperative ileus induced by surgical manipulation of murine colon. Am J Physiol Gastrointest Liver Physiol. 2004 Feb; 286(2):G214-24. Moore BA, Türler A, Pezzone MA, Dyer K, Grandis J, Bauer AJ. PMID: 14512290.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    281. Mitogenic effects of gastrin-releasing peptide in head and neck squamous cancer cells are mediated by activation of the epidermal growth factor receptor. Oncogene. 2003 Sep 18; 22(40):6183-93. Lui VW, Thomas SM, Zhang Q, Wentzel AL, Siegfried JM, Li JY, Grandis JR. PMID: 13679857.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    282. Responsiveness to the retinoic acid receptor-selective retinoid LGD1550 correlates with abrogation of transforming growth factor alpha/epidermal growth factor receptor autocrine signaling in head and neck squamous carcinoma cells. Clin Cancer Res. 2003 Sep 15; 9(11):4205-13. Lango M, Wentzel AL, Song JI, Xi S, Johnson DE, Lamph WW, Miller L, Grandis JR. PMID: 14519647.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    283. Epidermal growth factor receptor-stimulated activation of phospholipase Cgamma-1 promotes invasion of head and neck squamous cell carcinoma. Cancer Res. 2003 Sep 01; 63(17):5629-35. Thomas SM, Coppelli FM, Wells A, Gooding WE, Song J, Kassis J, Drenning SD, Grandis JR. PMID: 14500405.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    284. Abrogation of VEGF expression in human head and neck squamous cell carcinoma decreases angiogenic activity in vitro and in vivo. Int J Oncol. 2003 Sep; 23(3):577-83. Riedel F, Götte K, Li M, Hörmann K, Grandis JR. PMID: 12888890.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    285. Requirement of a carbon spacer in benzyl isothiocyanate-mediated cytotoxicity and MAPK activation in head and neck squamous cell carcinoma. Carcinogenesis. 2003 Oct; 24(10):1705-12. Lui VW, Wentzel AL, Xiao D, Lew KL, Singh SV, Grandis JR. PMID: 12896907.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    286. Tissue distribution of liposome-mediated epidermal growth factor receptor antisense gene therapy. Cancer Gene Ther. 2003 Jul; 10(7):518-28. Thomas SM, Zeng Q, Dyer KF, Suscovich TJ, Kanter PM, Whalen JD, Watkins SF, Grandis JR. PMID: 12833132.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    287. Activation of Stat3 by cell confluence reveals negative regulation of Stat3 by cdk2. Oncogene. 2003 Jun 05; 22(23):3608-15. Steinman RA, Wentzel A, Lu Y, Stehle C, Grandis JR. PMID: 12789269.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    288. Targeting epidermal growth factor receptor: novel therapeutics in the management of cancer. Expert Rev Anticancer Ther. 2003 Jun; 3(3):367-80. Khalil MY, Grandis JR, Shin DM. PMID: 12820779.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    289. Src kinases mediate STAT growth pathways in squamous cell carcinoma of the head and neck. J Biol Chem. 2003 Aug 22; 278(34):31574-83. Xi S, Zhang Q, Dyer KF, Lerner EC, Smithgall TE, Gooding WE, Kamens J, Grandis JR. PMID: 12771142.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansCells
    290. Targeted inhibition of Stat3 with a decoy oligonucleotide abrogates head and neck cancer cell growth. Proc Natl Acad Sci U S A. 2003 Apr 01; 100(7):4138-43. Leong PL, Andrews GA, Johnson DE, Dyer KF, Xi S, Mai JC, Robbins PD, Gadiparthi S, Burke NA, Watkins SF, Grandis JR. PMID: 12640143.
      View in: PubMed   Mentions: 105     Fields:    Translation:HumansCells
    291. The role of epidermal growth factor receptor in head and neck squamous cell carcinoma. Curr Oncol Rep. 2003 Mar; 5(2):140-6. Pomerantz RG, Grandis JR. PMID: 12583831.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    292. Differential activation of apoptosis regulatory pathways during monocytic vs granulocytic differentiation: a requirement for Bcl-X(L)and XIAP in the prolonged survival of monocytic cells. Leukemia. 2003 Feb; 17(2):390-400. Miranda MB, Dyer KF, Grandis JR, Johnson DE. PMID: 12592339.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    293. Gene therapy for the treatment of oral squamous cell carcinoma. J Dent Res. 2003 Jan; 82(1):11-6. Xi S, Grandis JR. PMID: 12508038.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    294. Targeting epidermal growth factor receptor in head and neck cancer. Head Neck. 2003 Jan; 25(1):67-73. Ford AC, Grandis JR. PMID: 12478546.
      View in: PubMed   Mentions: 25     Fields:    Translation:Humans
    295. Phospholipase C-gamma1 in tumor progression. Clin Exp Metastasis. 2003; 20(4):285-90. Wells A, Grandis JR. PMID: 12856715.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimals
    296. Enhanced antiangiogenic therapy of squamous cell carcinoma by combined endostatin and epidermal growth factor receptor-antisense therapy. Clin Cancer Res. 2002 Nov; 8(11):3570-8. Li M, Ye C, Feng C, Riedel F, Liu X, Zeng Q, Grandis JR. PMID: 12429648.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    297. Lipopolysaccharide preconditioning and cross-tolerance: the induction of protective mechanisms for rat intestinal ileus. Gastroenterology. 2002 Aug; 123(2):586-98. Schwarz NT, Engel B, Eskandari MK, Kalff JC, Grandis JR, Bauer AJ. PMID: 12145811.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    298. STAT3 activation abrogates growth factor dependence and contributes to head and neck squamous cell carcinoma tumor growth in vivo. Cell Growth Differ. 2002 Aug; 13(8):355-62. Kijima T, Niwa H, Steinman RA, Drenning SD, Gooding WE, Wentzel AL, Xi S, Grandis JR. PMID: 12193474.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansCells
    299. EGFR antisense treatment of human HNSCC cell lines down-regulates VEGF expression and endothelial cell migration. Int J Oncol. 2002 Jul; 21(1):11-6. Riedel F, Götte K, Li M, Hörmann K, Grandis JR. PMID: 12063543.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    300. Stat3 activation in prostatic carcinomas. Prostate. 2002 Jun 01; 51(4):241-6. Dhir R, Ni Z, Lou W, DeMiguel F, Grandis JR, Gao AC. PMID: 11987152.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansCells
    301. Lack of toxicity of EGFR antisense gene therapy. J Exp Ther Oncol. 2002 May-Jun; 2(3):174-86. Zeng Q, Kanter PM, Dhir R, Gooding WE, Huang L, Grandis JR. PMID: 12415634.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    302. Differential function of STAT5 isoforms in head and neck cancer growth control. Oncogene. 2002 Apr 25; 21(18):2846-53. Leong PL, Xi S, Drenning SD, Dyer KF, Wentzel AL, Lerner EC, Smithgall TE, Grandis JR. PMID: 11973644.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    303. Selective activation of members of the signal transducers and activators of transcription family in prostate carcinoma. J Urol. 2002 Apr; 167(4):1859-62. Ni Z, Lou W, Lee SO, Dhir R, DeMiguel F, Grandis JR, Gao AC. PMID: 11912448.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    304. Gastrin-releasing peptide receptor-mediated autocrine growth in squamous cell carcinoma of the head and neck. J Natl Cancer Inst. 2002 Mar 06; 94(5):375-83. Lango MN, Dyer KF, Lui VW, Gooding WE, Gubish C, Siegfried JM, Grandis JR. PMID: 11880476.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimals
    305. EGFR-mediated cell cycle regulation. Anticancer Res. 2002 Jan-Feb; 22(1A):1-11. Lui VW, Grandis JR. PMID: 12017269.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    306. Expression of androgen receptor, epidermal growth factor receptor, and transforming growth factor alpha in salivary duct carcinoma. Arch Otolaryngol Head Neck Surg. 2001 Sep; 127(9):1075-9. Fan CY, Melhem MF, Hosal AS, Grandis JR, Barnes EL. PMID: 11556855.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    307. Abrogation of transforming growth factor-alpha/epidermal growth factor receptor autocrine signaling by an RXR-selective retinoid (LGD1069, Targretin) in head and neck cancer cell lines. Cancer Res. 2001 Aug 01; 61(15):5919-25. Song JI, Lango MN, Hwang JD, Drenning SD, Zeng Q, Lamph WW, Grandis JR. PMID: 11479234.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    308. Targeting growth factor receptors: integration of novel therapeutics in the management of head and neck cancer. Curr Opin Oncol. 2001 May; 13(3):168-75. Lango MN, Shin DM, Grandis JR. PMID: 11307060.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    309. The role of topical antibiotic prophylaxis in patients undergoing contaminated head and neck surgery with flap reconstruction. Laryngoscope. 2001 Feb; 111(2):329-35. Simons JP, Johnson JT, Yu VL, Vickers RM, Gooding WE, Myers EN, Pou AM, Wagner RL, Grandis JR. PMID: 11210884.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCTClinical Trials
    310. Human leukocyte antigen class I allelic and haplotype loss in squamous cell carcinoma of the head and neck: clinical and immunogenetic consequences. Clin Cancer Res. 2000 Jul; 6(7):2794-802. Grandis JR, Falkner DM, Melhem MF, Gooding WE, Drenning SD, Morel PA. PMID: 10914726.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    311. Determination of intermediate biomarker expression levels by quantitative reverse transcription-polymerase chain reaction in oral mucosa of cancer patients treated with liarozole. Clin Cancer Res. 2000 Jun; 6(6):2245-51. Zeng Q, Smith DC, Suscovich TJ, Gooding WE, Trump DL, Grandis JR. PMID: 10873074.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCellsCTClinical Trials
    312. STAT signaling in head and neck cancer. Oncogene. 2000 May 15; 19(21):2489-95. Song JI, Grandis JR. PMID: 10851047.
      View in: PubMed   Mentions: 99     Fields:    Translation:HumansCells
    313. Constitutive activation of Stat3 signaling abrogates apoptosis in squamous cell carcinogenesis in vivo. Proc Natl Acad Sci U S A. 2000 Apr 11; 97(8):4227-32. Grandis JR, Drenning SD, Zeng Q, Watkins SC, Melhem MF, Endo S, Johnson DE, Huang L, He Y, Kim JD. PMID: 10760290.
      View in: PubMed   Mentions: 174     Fields:    Translation:HumansAnimalsCells
    314. Endoscopic sphenopalatine artery ligation is an effective method of treatment for posterior epistaxis. Am J Rhinol. 1999 Mar-Apr; 13(2):137-40. Snyderman CH, Goldman SA, Carrau RL, Ferguson BJ, Grandis JR. PMID: 10219443.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    315. Bcl-2 but not Bax expression is associated with apoptosis in normal and transformed squamous epithelium. Clin Cancer Res. 1998 Nov; 4(11):2913-21. Drenning SD, Marcovitch AJ, Johnson DE, Melhem MF, Tweardy DJ, Grandis JR. PMID: 9829760.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    316. Requirement of Stat3 but not Stat1 activation for epidermal growth factor receptor- mediated cell growth In vitro. J Clin Invest. 1998 Oct 01; 102(7):1385-92. Grandis JR, Drenning SD, Chakraborty A, Zhou MY, Zeng Q, Pitt AS, Tweardy DJ. PMID: 9769331.
      View in: PubMed   Mentions: 133     Fields:    Translation:HumansCells
    317. Growth and differentiation of rat hepatocytes: changes in transcription factors HNF-3, HNF-4, STAT-3, and STAT-5. Biochem Biophys Res Commun. 1998 Sep 29; 250(3):762-8. Runge D, Runge DM, Drenning SD, Bowen WC, Grandis JR, Michalopoulos GK. PMID: 9784420.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    318. Normalization of EGFR mRNA levels following restoration of wild-type p53 in a head and neck squamous cell carcinoma cell line. Int J Oncol. 1998 Aug; 13(2):375-8. Grandis JR, Zeng Q, Drenning SD, Tweardy DJ. PMID: 9664135.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    319. Inhibition of human squamous cell carcinoma growth in vivo by epidermal growth factor receptor antisense RNA transcribed from the U6 promoter. J Natl Cancer Inst. 1998 Jul 15; 90(14):1080-7. He Y, Zeng Q, Drenning SD, Melhem MF, Tweardy DJ, Huang L, Grandis JR. PMID: 9672256.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    320. Subglottic injury, gastric juice, corticosteroids, and peptide growth factors in a porcine model. Laryngoscope. 1998 Jun; 108(6):854-62. Yellon RF, Szeremeta W, Grandis JR, Diguisseppe P, Dickman PS. PMID: 9628501.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    321. Downmodulation of TGF-alpha protein expression with antisense oligonucleotides inhibits proliferation of head and neck squamous carcinoma but not normal mucosal epithelial cells. J Cell Biochem. 1998 Apr 01; 69(1):55-62. Grandis JR, Chakraborty A, Zeng Q, Melhem MF, Tweardy DJ. PMID: 9513046.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    322. Tumor Board Conference from the University of Pittsburgh. Oncology (Williston Park). 1997 Jul; 11(7):1033-9. Pitman KT, Agarwala SS, Cano ER, Eibling DE, Fagan JJ, Grandis JR, Johnson JT, Myers EN, Russavage JM, Snyderman CH, Weismann JL. PMID: 9251122.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    323. Lack of serologic evidence for Helicobacter pylori infection in head and neck cancer. Head Neck. 1997 May; 19(3):216-8. Grandis JR, Perez-Perez GI, Yu VL, Johnson JT, Blaser MJ. PMID: 9142522.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    324. Role of subglottic injury, gastric juice, and peptide growth factors in a porcine model. Int Anesthesiol Clin. 1997; 35(3):115-25. Yellon RF, Szeremeta W, Grandis JR, Diguisseppe P, Dickman PS. PMID: 9361983.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    325. Necrotizing (malignant) external otitis: prospective comparison of CT and MR imaging in diagnosis and follow-up. Radiology. 1995 Aug; 196(2):499-504. Grandis JR, Curtin HD, Yu VL. PMID: 7617867.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    326. Antitumor activity of interleukin-1 alpha and cisplatin in a murine model system. Arch Otolaryngol Head Neck Surg. 1995 Feb; 121(2):197-200. Grandis JR, Chang MJ, Yu WD, Johnson CS. PMID: 7840928.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    327. Efficacy of topical amoxicillin plus clavulanate/ticarcillin plus clavulanate and clindamycin in contaminated head and neck surgery: effect of antibiotic spectra and duration of therapy. J Infect Dis. 1994 Sep; 170(3):729-32. Grandis JR, Vickers RM, Rihs JD, Yu VL, Johnson JT. PMID: 8077738.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCellsCTClinical Trials
    328. The efficacy of topical antibiotic prophylaxis for contaminated head and neck surgery. Laryngoscope. 1994 Jun; 104(6 Pt 1):719-24. Grandis JR, Vickers RM, Rihs JD, Yu VL, Wagner RL, Kachman KK, Johnson JT. PMID: 8196446.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCellsCTClinical Trials
    329. Elevated levels of transforming growth factor alpha and epidermal growth factor receptor messenger RNA are early markers of carcinogenesis in head and neck cancer. Cancer Res. 1993 Aug 01; 53(15):3579-84. Grandis JR, Tweardy DJ. PMID: 8339264.
      View in: PubMed   Mentions: 203     Fields:    Translation:HumansCells
    330. Simultaneous presentation of malignant external otitis and temporal bone cancer. Arch Otolaryngol Head Neck Surg. 1993 Jun; 119(6):687-9. Grandis JR, Hirsch BE, Yu VL. PMID: 8499104.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    331. Treatment of idiopathic sudden sensorineural hearing loss. Am J Otol. 1993 Mar; 14(2):183-5. Grandis JR, Hirsch BE, Wagener MM. PMID: 8503494.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    332. TGF-alpha and EGFR in head and neck cancer. J Cell Biochem Suppl. 1993; 17F:188-91. Grandis JR, Tweardy DJ. PMID: 8412192.
      View in: PubMed   Mentions: 28     Fields:    Translation:Humans
    333. Head and neck cancer. Arch Otolaryngol Head Neck Surg. 1993 Jan; 119(1):121. Snyderman CH, Grandis JR, Johnson JT. PMID: 8417737.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    334. Synergistic enhancement by interleukin-1 alpha of cisplatin-mediated antitumor activity in RIF-1 tumor-bearing C3H/HeJ mice. Cancer Chemother Pharmacol. 1993; 32(5):339-46. Johnson CS, Chang MJ, Yu WD, Modzelewski RA, Grandis JR, Vlock DR, Furmanski P. PMID: 8339383.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    335. Postoperative wound infection. A poor prognostic sign for patients with head and neck cancer. Cancer. 1992 Oct 15; 70(8):2166-70. Grandis JR, Snyderman CH, Johnson JT, Yu VL, D'Amico F. PMID: 1394047.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    336. The role of peptide growth factors in head and neck carcinoma. Otolaryngol Clin North Am. 1992 Oct; 25(5):1105-15. Grandis JR, Tweardy DJ. PMID: 1408194.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    337. The efficacy of perioperative antibiotic therapy on recovery following tonsillectomy in adults: randomized double-blind placebo-controlled trial. Otolaryngol Head Neck Surg. 1992 Feb; 106(2):137-42. Grandis JR, Johnson JT, Vickers RM, Yu VL, Wagener MM, Wagner RL, Kachman KA. PMID: 1738544.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCTClinical Trials
    338. Stomal recurrence after laryngectomy: interrelated risk factor study. Otolaryngol Head Neck Surg. 1990 Nov; 103(5 ( Pt 1)):805-12. Rubin J, Johnson JT, Myers EN. PMID: 2126104.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    339. Extramedullary plasmacytoma of the thyroid associated with a serum monoclonal gammopathy. Arch Otolaryngol Head Neck Surg. 1990 Jul; 116(7):855-9. Rubin J, Johnson JT, Killeen R, Barnes L. PMID: 2363927.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    340. Malignant external otitis: utility of CT in diagnosis and follow-up. Radiology. 1990 Feb; 174(2):391-4. Rubin J, Curtin HD, Yu VL, Kamerer DB. PMID: 2104989.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    341. Aural irrigation with water: a potential pathogenic mechanism for inducing malignant external otitis? Ann Otol Rhinol Laryngol. 1990 Feb; 99(2 Pt 1):117-9. Rubin J, Yu VL, Kamerer DB, Wagener M. PMID: 2301865.
      View in: PubMed   Mentions:    Fields:    Translation:HumansPHPublic Health
    342. Efficacy of oral ciprofloxacin plus rifampin for treatment of malignant external otitis. Arch Otolaryngol Head Neck Surg. 1989 Sep; 115(9):1063-9. Rubin J, Stoehr G, Yu VL, Muder RR, Matador A, Kamerer DB. PMID: 2504254.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    343. Malignant external otitis in children. J Pediatr. 1988 Dec; 113(6):965-70. Rubin J, Yu VL, Stool SE. PMID: 3142986.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    344. Malignant external otitis: insights into pathogenesis, clinical manifestations, diagnosis, and therapy. Am J Med. 1988 Sep; 85(3):391-8. Rubin J, Yu VL. PMID: 3046354.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    345. Bacteriologic analysis of wound infection following major head and neck surgery. Arch Otolaryngol Head Neck Surg. 1988 Sep; 114(9):969-72. Rubin J, Johnson JT, Wagner RL, Yu VL. PMID: 3408577.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
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