Christopher Tinkle, MD, PhD

Title(s)Assistant Member, Neurology
SchoolSchool of Medicine
Address262 Danny Thomas Place, MS 210
Memphis TN 38105
Phone901-595-8735
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    Other Positions
    Title(s)UCSF Weill Institute for Neurosciences


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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Revised clinical and molecular risk strata define the incidence and pattern of failure in Medulloblastoma following risk-adapted radiotherapy and dose-intensive chemotherapy: results from a phase III multi-institutional study. Neuro Oncol. 2021 Dec 11. Lucas JT, Tinkle CL, Huang J, Onar-Thomas A, Srinivasan S, Tumlin P, Becksfort J, Klimo P, Boop FA, Robinson GW, Orr BA, Harreld JH, Krasin MJ, Northcott PA, Ellison DW, Gajjar A, Merchant TE. PMID: 34894262.
      View in: PubMed   Mentions:
    2. Phase I study using crenolanib to target PDGFR kinase in children and young adults with newly diagnosed DIPG or recurrent high-grade glioma, including DIPG. Neurooncol Adv. 2021 Jan-Dec; 3(1):vdab179. Tinkle CL, Broniscer A, Chiang J, Campagne O, Huang J, Orr BA, Li X, Patay Z, Zhang J, Baker SJ, Merchant TE, Jain V, Onar-Thomas A, Stewart CF, Wetmore C, Gajjar A. PMID: 34993482; PMCID: PMC8717895.
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    3. Accuracy of Central Neuro-Imaging Review of DIPG Compared with Histopathology in the International DIPG Registry. Neuro Oncol. 2021 Oct 20. Lazow MA, Fuller C, DeWire M, Lane A, Bandopadhayay P, Bartels U, Bouffet E, Cheng S, Cohen KJ, Cooney TM, Coven SL, Dholaria H, Diez B, Dorris K, El-Ayadi M, El-Sheikh A, Fisher PG, Fonseca A, Lombardi MG, Greiner RJ, Goldman S, Gottardo N, Gururangan S, Hansford JR, Hassall T, Hawkins C, Kilburn L, Koschmann C, Leary SE, Ma J, Minturn JE, Monje-Deisseroth M, Packer R, Samson Y, Sandler ES, Sevlever G, Tinkle CL, Tsui K, Wagner LM, Zaghloul M, Ziegler DS, Chaney B, Black K, Asher A, Drissi R, Fouladi M, Jones BV, Leach JL. PMID: 34668975.
      View in: PubMed   Mentions:    Fields:    
    4. Data vignettes for the application of response surface models in drug combination analysis. Data Brief. 2021 Oct; 38:107400. Twarog NR, Martinez NE, Gartrell J, Xie J, Tinkle CL, Shelat AA. PMID: 34589567; PMCID: PMC8461350.
      View in: PubMed   Mentions:
    5. SLFN11 is Widely Expressed in Pediatric Sarcoma and Induces Variable Sensitization to Replicative Stress Caused By DNA-Damaging Agents. Mol Cancer Ther. 2021 Aug 19. Gartrell J, Mellado-Largarde M, Clay MR, Bahrami A, Sahr NA, Sykes A, Blankenship K, Hoffmann L, Xie J, Cho HP, Twarog N, Connelly M, Yan KK, Yu J, Porter SN, Pruett-Miller SM, Neale G, Tinkle CL, Federico SM, Stewart EA, Shelat AA. PMID: 34413129.
      View in: PubMed   Mentions:    Fields:    
    6. Patient-derived models recapitulate heterogeneity of molecular signatures and drug response in pediatric high-grade glioma. Nat Commun. 2021 07 02; 12(1):4089. He C, Xu K, Zhu X, Dunphy PS, Gudenas B, Lin W, Twarog N, Hover LD, Kwon CH, Kasper LH, Zhang J, Li X, Dalton J, Jonchere B, Mercer KS, Currier DG, Caufield W, Wang Y, Xie J, Broniscer A, Wetmore C, Upadhyaya SA, Qaddoumi I, Klimo P, Boop F, Gajjar A, Zhang J, Orr BA, Robinson GW, Monje M, Freeman Iii BB, Roussel MF, Northcott PA, Chen T, Rankovic Z, Wu G, Chiang J, Tinkle CL, Shelat AA, Baker SJ. PMID: 34215733; PMCID: PMC8253809.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    7. Multi-institutional analysis of treatment modalities in basal ganglia and thalamic germinoma. Pediatr Blood Cancer. 2021 Oct; 68(10):e29172. Graham RT, Abu-Arja MH, Stanek JR, Cappellano A, Coleman C, Chi S, Cooney T, Dhall G, Ellen JG, Finlay JL, Fisher MJ, Friedman GK, Gajjar A, Gauvain K, Hoffman LM, Hukin J, Lucas JT, Mueller S, Navalkele P, Ronsley R, Tinkle C, Villeneuve S, Yeo KK, Su JM, Margol A, Gottardo NG, Allen J, Packer R, Bartels U, Abdelbaki MS. PMID: 34125480.
      View in: PubMed   Mentions:    Fields:    
    8. Using response surface models to analyze drug combinations. Drug Discov Today. 2021 08; 26(8):2014-2024. Twarog NR, Martinez NE, Gartrell J, Xie J, Tinkle CL, Shelat AA. PMID: 34119666; PMCID: PMC8410662.
      View in: PubMed   Mentions: 1     Fields:    
    9. Model-based evaluation of image-guided fractionated whole-brain radiation therapy in pediatric diffuse intrinsic pontine glioma xenografts. CPT Pharmacometrics Syst Pharmacol. 2021 06; 10(6):599-610. Husband HR, Campagne O, He C, Zhu X, Bianski BM, Baker SJ, Shelat AA, Tinkle CL, Stewart CF. PMID: 33939327; PMCID: PMC8213420.
      View in: PubMed   Mentions:    Fields:    
    10. Late effects of radiation therapy in pediatric patients and survivorship. Pediatr Blood Cancer. 2021 05; 68 Suppl 2:e28349. Palmer JD, Tsang DS, Tinkle CL, Olch AJ, Kremer LCM, Ronckers CM, Gibbs IC, Constine LS. PMID: 33818893.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    11. NTRK Fusions Can Co-Occur With H3K27M Mutations and May Define Druggable Subclones Within Diffuse Midline Gliomas. J Neuropathol Exp Neurol. 2021 Mar 22; 80(4):345-353. Dahl NA, Donson AM, Sanford B, Wang D, Walker FM, Gilani A, Foreman NK, Tinkle CL, Baker SJ, Hoffman LM, Venkataraman S, Vibhakar R. PMID: 33749791; PMCID: PMC7985828.
      View in: PubMed   Mentions:    Fields:    
    12. Stereotactic Body Radiation Therapy for Metastatic and Recurrent Solid Tumors in Children and Young Adults. Int J Radiat Oncol Biol Phys. 2021 04 01; 109(5):1396-1405. Tinkle CL, Singh C, Lloyd S, Guo Y, Li Y, Pappo AS, DuBois SG, Lucas JT, Haas-Kogan DA, Terezakis SA, Braunstein SE, Krasin MJ. PMID: 33259934; PMCID: PMC7965242.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansPHPublic Health
    13. Assessment and Treatment Outcomes of Persistent Radiation-Induced Alopecia in Patients With Cancer. JAMA Dermatol. 2020 09 01; 156(9):963-972. Phillips GS, Freret ME, Friedman DN, Trelles S, Kukoyi O, Freites-Martinez A, Unger RH, Disa JJ, Wexler LH, Tinkle CL, Mechalakos JG, Dusza SW, Beal K, Wolden SL, Lacouture ME. PMID: 32756880; PMCID: PMC7407362.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansPHPublic Health
    14. Safety and efficacy of brainstem biopsy in children and young adults. J Neurosurg Pediatr. 2020 Jul 31; 1-11. Hersh DS, Kumar R, Moore KA, Smith LGF, Tinkle CL, Chiang J, Patay Z, Gajjar A, Choudhri AF, Lee-Diaz JA, Vaughn B, Klimo P. PMID: 32736346.
      View in: PubMed   Mentions: 1     Fields:    
    15. Clinical, imaging, and molecular analysis of pediatric pontine tumors lacking characteristic imaging features of DIPG. Acta Neuropathol Commun. 2020 04 23; 8(1):57. Chiang J, Diaz AK, Makepeace L, Li X, Han Y, Li Y, Klimo P, Boop FA, Baker SJ, Gajjar A, Merchant TE, Ellison DW, Broniscer A, Patay Z, Tinkle CL. PMID: 32326973; PMCID: PMC7181591.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    16. Radiation dose response of neurologic symptoms during conformal radiotherapy for diffuse intrinsic pontine glioma. J Neurooncol. 2020 Mar; 147(1):195-203. Tinkle CL, Campbell K, Han Y, Li Y, Bianski B, Broniscer A, Khan RB, Merchant TE. PMID: 32016716; PMCID: PMC7080561.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    17. Efficacy and Safety of Limited-Margin Conformal Radiation Therapy for Pediatric Rhabdomyosarcoma: Long-Term Results of a Phase 2 Study. Int J Radiat Oncol Biol Phys. 2020 05 01; 107(1):172-180. Tinkle CL, Pappo A, Wu J, Mao S, Hua CH, Shulkin BL, McCarville MB, Kaste SC, Davidoff AM, Bahrami A, Green DM, Ness KK, Merchant TE, Spunt SL, Krasin MJ. PMID: 31987969; PMCID: PMC7668436.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCTClinical Trials
    18. MRI Patterns of Extrapontine Lesion Extension in Diffuse Intrinsic Pontine Gliomas. AJNR Am J Neuroradiol. 2020 02; 41(2):323-330. Makepeace L, Scoggins M, Mitrea B, Li Y, Edwards A, Tinkle CL, Hwang S, Gajjar A, Patay Z. PMID: 31974084; PMCID: PMC7015203.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    19. Preclinical Models of Craniospinal Irradiation for Medulloblastoma. Cancers (Basel). 2020 Jan 05; 12(1). Stripay JL, Merchant TE, Roussel MF, Tinkle CL. PMID: 31948065; PMCID: PMC7016884.
      View in: PubMed   Mentions: 2  
    20. Defining Optimal Target Volumes of Conformal Radiation Therapy for Diffuse Intrinsic Pontine Glioma. Int J Radiat Oncol Biol Phys. 2020 03 15; 106(4):838-847. Tinkle CL, Simone B, Chiang J, Li X, Campbell K, Han Y, Li Y, Hover LD, Molitoris JK, Becksfort J, Lucas JT, Patay Z, Baker SJ, Broniscer A, Merchant TE. PMID: 31785339; PMCID: PMC7042090.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    21. An LC/ESI-MS/MS method to quantify the PI3K inhibitor GDC-0084 in human plasma and cerebrospinal fluid: Validation and clinical application. Biomed Chromatogr. 2020 Jan; 34(1):e4697. Zhong B, Campagne O, Tinkle CL, Stewart CF. PMID: 31495945; PMCID: PMC7052798.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    22. Molecular grouping and outcomes of young children with newly diagnosed ependymoma treated on the multi-institutional SJYC07 trial. Neuro Oncol. 2019 10 09; 21(10):1319-1330. Upadhyaya SA, Robinson GW, Onar-Thomas A, Orr BA, Billups CA, Bowers DC, Bendel AE, Hassall T, Crawford JR, Partap S, Fisher PG, Tatevossian RG, Seah T, Qaddoumi IA, Vinitsky A, Armstrong GT, Sabin ND, Tinkle CL, Klimo P, Indelicato DJ, Boop FA, Merchant TE, Ellison DW, Gajjar A. PMID: 30976811; PMCID: PMC6784269.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCTClinical Trials
    23. A single-center study of the clinicopathologic correlates of gliomas with a MYB or MYBL1 alteration. Acta Neuropathol. 2019 12; 138(6):1091-1092. Chiang J, Harreld JH, Tinkle CL, Moreira DC, Li X, Acharya S, Qaddoumi I, Ellison DW. PMID: 31595312; PMCID: PMC7467132.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    24. Association between hippocampal dose and memory in survivors of childhood or adolescent low-grade glioma: a 10-year neurocognitive longitudinal study. Neuro Oncol. 2019 09 06; 21(9):1175-1183. Acharya S, Wu S, Ashford JM, Tinkle CL, Lucas JT, Qaddoumi I, Gajjar A, Krasin MJ, Conklin HM, Merchant TE. PMID: 30977510; PMCID: PMC7594551.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    25. Curative-intent radiotherapy for pediatric osteosarcoma: The St. Jude experience. Pediatr Blood Cancer. 2019 08; 66(8):e27763. Tinkle CL, Lu J, Han Y, Li Y, McCarville BM, Neel MD, Bishop MW, Krasin MJ. PMID: 31012273; PMCID: PMC6588458.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    26. Treatment patterns and disease outcomes for pediatric patients with refractory or recurrent Hodgkin lymphoma treated with curative-intent salvage radiotherapy. Radiother Oncol. 2019 05; 134:89-95. Tinkle CL, Williams NL, Wu H, Wu J, Kaste SC, Shulkin BL, Talleur AC, Flerlage JE, Hudson MM, Metzger ML, Krasin MJ. PMID: 31005229; PMCID: PMC6478442.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    27. Histone H3.3 K27M Accelerates Spontaneous Brainstem Glioma and Drives Restricted Changes in Bivalent Gene Expression. Cancer Cell. 2019 01 14; 35(1):140-155.e7. Larson JD, Kasper LH, Paugh BS, Jin H, Wu G, Kwon CH, Fan Y, Shaw TI, Silveira AB, Qu C, Xu R, Zhu X, Zhang J, Russell HR, Peters JL, Finkelstein D, Xu B, Lin T, Tinkle CL, Patay Z, Onar-Thomas A, Pounds SB, McKinnon PJ, Ellison DW, Zhang J, Baker SJ. PMID: 30595505; PMCID: PMC6570409.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansAnimalsCells
    28. Preclinical Modeling of Image-Guided Craniospinal Irradiation for Very-High-Risk Medulloblastoma. Int J Radiat Oncol Biol Phys. 2019 03 01; 103(3):728-737. Smith SMC, Bianski BM, Orr BA, Harknett G, Onar-Thomas A, Gilbertson RJ, Merchant TE, Roussel MF, Tinkle CL. PMID: 30366006; PMCID: PMC6421074.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsPHPublic Health
    29. Long-Term Risk of Venous Thromboembolism in Survivors of Childhood Cancer: A Report From the Childhood Cancer Survivor Study. J Clin Oncol. 2018 Sep 14; JCO2018784595. Madenci AL, Weil BR, Liu Q, Murphy AJ, Gibson TM, Yasui Y, Leisenring WM, Howell RM, Tinkle CL, Nekhlyudov L, Diller LR, Armstrong GT, Oeffinger KC, Weldon CB. PMID: 30216123.
      View in: PubMed   Mentions: 2     Fields:    
    30. Evaluation of 11C-Methionine PET and Anatomic MRI Associations in Diffuse Intrinsic Pontine Glioma. J Nucl Med. 2019 03; 60(3):312-319. Tinkle CL, Duncan EC, Doubrovin M, Han Y, Li Y, Kim H, Broniscer A, Snyder SE, Merchant TE, Shulkin BL. PMID: 30072503; PMCID: PMC6424234.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    31. Late Infection-Related Mortality in Asplenic Survivors of Childhood Cancer: A Report From the Childhood Cancer Survivor Study. J Clin Oncol. 2018 06 01; 36(16):1571-1578. Weil BR, Madenci AL, Liu Q, Howell RM, Gibson TM, Yasui Y, Neglia JP, Leisenring WM, Smith SA, Tonorezos ES, Friedman DN, Constine LS, Tinkle CL, Diller LR, Armstrong GT, Oeffinger KC, Weldon CB. PMID: 29664715; PMCID: PMC5978467.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    32. Clinical Implementation of Magnetic Resonance Imaging Systems for Simulation and Planning of Pediatric Radiation Therapy. J Med Imaging Radiat Sci. 2018 Jun; 49(2):153-163. Hua CH, Uh J, Krasin MJ, Lucas JT, Tinkle CL, Acharya S, Smith HL, Kadbi M, Merchant TE. PMID: 32074033.
      View in: PubMed   Mentions: 1     Fields:    
    33. Radiomics Features Differentiate Between Normal and Tumoral High-Fdg Uptake. Sci Rep. 2018 03 02; 8(1):3913. Hsu CY, Doubrovin M, Hua CH, Mohammed O, Shulkin BL, Kaste S, Federico S, Metzger M, Krasin M, Tinkle C, Merchant TE, Lucas JT. PMID: 29500442; PMCID: PMC5834444.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    34. Nonrhabdomyosarcoma soft tissue sarcoma (NRSTS) in pediatric and young adult patients: Results from a prospective study using limited-margin radiotherapy. Cancer. 2017 Nov 15; 123(22):4419-4429. Tinkle CL, Fernandez-Pineda I, Sykes A, Lu Z, Hua CH, Neel MD, Bahrami A, Shulkin BL, Kaste SC, Pappo A, Spunt SL, Krasin MJ. PMID: 28759114; PMCID: PMC5673566.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCTClinical Trials
    35. Craniospinal irradiation for treatment of metastatic pediatric low-grade glioma. J Neurooncol. 2017 Sep; 134(2):317-324. Tsang DS, Murphy ES, Ezell SE, Lucas JT, Tinkle C, Merchant TE. PMID: 28623604.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    36. Quantification of Pediatric Abdominal Organ Motion With a 4-Dimensional Magnetic Resonance Imaging Method. Int J Radiat Oncol Biol Phys. 2017 09 01; 99(1):227-237. Uh J, Krasin MJ, Li Y, Li X, Tinkle C, Lucas JT, Merchant TE, Hua C. PMID: 28816151.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    37. Prognostic Relevance of Treatment Failure Patterns in Pediatric High-Grade Glioma: Is There a Role for a Revised Failure Classification System? Int J Radiat Oncol Biol Phys. 2017 10 01; 99(2):450-458. Lucas JT, Cooper DA, Hwang S, Tinkle C, Li X, Li Y, Orr B, Merchant TE, Broniscer A. PMID: 28871996.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCTClinical Trials
    38. Late toxicity and outcomes following radiation therapy for chest wall sarcomas in pediatric patients. Pract Radiat Oncol. 2017 Nov - Dec; 7(6):411-417. Lucas JT, Fernandez-Pineda I, Tinkle CL, Bishop MW, Kaste SC, Heda R, Davidoff AM, Krasin MJ. PMID: 28676226.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansPHPublic Health
    39. Rapid and fulminant leptomeningeal spread following radiotherapy in diffuse intrinsic pontine glioma. Pediatr Blood Cancer. 2017 Aug; 64(8). Tinkle CL, Orr BA, Lucas JT, Klimo P, Patay Z, Baker SJ, Broniscer A, Qaddoumi I. PMID: 28084680; PMCID: PMC5796806.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    40. Intraoperative Radiotherapy in the Management of Locally Recurrent Extremity Soft Tissue Sarcoma. Sarcoma. 2015; 2015:913565. Tinkle CL, Weinberg V, Braunstein SE, Wustrack R, Horvai A, Jahan T, O'Donnell RJ, Gottschalk AR. PMID: 26346118; PMCID: PMC4546758.
      View in: PubMed   Mentions: 6  
    41. Inverse Planned High-Dose-Rate Brachytherapy for Locoregionally Advanced Cervical Cancer: 4-Year Outcomes. Int J Radiat Oncol Biol Phys. 2015 Aug 01; 92(5):1093-1100. Tinkle CL, Weinberg V, Chen LM, Littell R, Cunha JAM, Sethi RA, Chan JK, Hsu IC. PMID: 26194683.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansPHPublic Health
    42. Hepatocellular carcinoma: natural history, current management, and emerging tools. Biologics. 2012; 6:207-19. Tinkle CL, Haas-Kogan D. PMID: 22904613; PMCID: PMC3421475.
      View in: PubMed   Mentions: 27  
    43. New insights into cadherin function in epidermal sheet formation and maintenance of tissue integrity. Proc Natl Acad Sci U S A. 2008 Oct 07; 105(40):15405-10. Tinkle CL, Pasolli HA, Stokes N, Fuchs E. PMID: 18809908; PMCID: PMC2547466.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    44. Conditional targeting of E-cadherin in skin: insights into hyperproliferative and degenerative responses. Proc Natl Acad Sci U S A. 2004 Jan 13; 101(2):552-7. Tinkle CL, Lechler T, Pasolli HA, Fuchs E. PMID: 14704278; PMCID: PMC327185.
      View in: PubMed   Mentions: 74     Fields:    Translation:Animals
    45. MMP-9 supplied by bone marrow-derived cells contributes to skin carcinogenesis. Cell. 2000 Oct 27; 103(3):481-90. Coussens LM, Tinkle CL, Hanahan D, Werb Z. PMID: 11081634; PMCID: PMC2843102.
      View in: PubMed   Mentions: 390     Fields:    Translation:AnimalsCells
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