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Bruce Faddegon, PhD

TitleProfessor
InstitutionUniversity of California San Francisco
DepartmentRadiation Oncology
Address1600 Divisadero
San Francisco CA 94115
Phone415-353-7195
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    Collapse Overview
    Dr. Faddegon is a board certified clinical medical physics who is internationally recognized for his research in developing and using Monte Carlo methods for treatment head simulation and dose calculation with an eye to improving accuracy and precision in radiotherapy. The overall objective of Dr. Faddegon’s research is to allow for more aggressive treatment in sites where side effects, local control, and even metastases are a problem through cost-effective solutions to improve the therapeutic ratio.

    Current research includes developing TOPAS, the Tool for Particle Simulation, a collaboration of UCSF, MGH and SLAC supported by NIH to improve advanced simulation of proton therapy, and developing XPERT, X-ray Plus Electron Radiotherapy, adding electrons to intensity-modulated radiotherapy with x-rays to reduce serious side-effects of radiation, especially in children. Dr. Faddegon is also working to establish image-guided radiotherapy with portal imaging for more precise targeting of tumors and avoidance of critical structures.

    Dr. Faddegons clinical responsibility is physics support of linear accelerators (linacs). This includes management, installation, commissioning, maintenance and quality assurance. Highlights of Dr. Faddegon’s published clinical development work at UCSF include developing the means to treat the whole body over a short distance (3 meters), developing new x-ray targets to reduce downtime that are implemented on linacs worldwide, implementing high precision graticules for patient localization, and determining the means to detect and correct defective circuitry in treatments using virtual wedges.


    Collapse Research 
    Collapse Research Activities and Funding
    The TOPAS Tool for Particle Simulation, a Monte Carlo Simulation Tool for Physics, Biology and Clinical Research
    NIH/NCI U24CA215123Jun 4, 2018 - May 31, 2023
    Role: Principal Investigator
    PRISM: Precision Radiotherapy and Imaging of Small Mammals
    NIH S10OD021818Apr 15, 2017 - Apr 14, 2018
    Role: Principal Investigator
    NAPTA: Optimizing clinical trial design & delivery of particle therapy for cancer
    NIH/NCI P20CA183640Feb 10, 2015 - Jan 31, 2017
    Role: Co-Investigator
    Accurate, easy-to-commission radiotherapy beam models
    NIH/NCI R01CA104777Jul 1, 2005 - Jun 30, 2009
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Lazar AA, Schulte R, Faddegon B, Blakely EA, Roach M. Clinical trials involving carbon-ion radiation therapy and the path forward. Cancer. 2018 Oct 11. PMID: 30307603.
      View in: PubMed
    2. McNamara AL, Ramos-Mendez J, Perl J, Held K, Dominguez N, Moreno EB, Henthorn NT, Kirkby KJ, Meylan S, Villagrasa C, Incerti S, Faddegon B, Paganetti H, Schuemann J. Geometrical structures for radiation biology research as implemented in the TOPAS-nBio toolkit. Phys Med Biol. 2018 Aug 08. PMID: 30088810.
      View in: PubMed
    3. Piersimoni P, Faddegon BA, Méndez JR, Schulte RW, Volz L, Seco J. Helium CT: Monte Carlo simulation results for an ideal source and detector with comparison to proton CT. Med Phys. 2018 May 04. PMID: 29727481.
      View in: PubMed
    4. Ramos-Méndez J, Schuemann J, Incerti S, Paganetti H, Schulte R, Faddegon B. Flagged uniform particle splitting for variance reduction in proton and carbon ion track-structure simulations. Phys Med Biol. 2017 Jul 06; 62(15):5908-5925. PMID: 28594336.
      View in: PubMed
    5. McNamara A, Geng C, Turner R, Mendez JR, Perl J, Held K, Faddegon B, Paganetti H, Schuemann J. Validation of the radiobiology toolkit TOPAS-nBio in simple DNA geometries. Phys Med. 2017 Jan; 33:207-215. PMID: 28017738.
      View in: PubMed
    6. Roach M, Schulte R, Mishra K, Faddegon B, Barani I, Lazar A, Blakely EA. New Clinical and Research Programs in Particle Beam Radiation Therapy: The University of California San Francisco Perspective. Int J Part Ther. 2016; 2(3):471-473. PMID: 27099866.
      View in: PubMed
    7. Geng C, Moteabbed M, Seco J, Gao Y, Xu XG, Ramos-Méndez J, Faddegon B, Paganetti H. Dose assessment for the fetus considering scattered and secondary radiation from photon and proton therapy when treating a brain tumor of the mother. Phys Med Biol. 2016 Jan 21; 61(2):683-95. PMID: 26716718.
      View in: PubMed
    8. Faddegon BA, Shin J, Castenada CM, Ramos-Méndez J, Daftari IK. Experimental depth dose curves of a 67.5 MeV proton beam for benchmarking and validation of Monte Carlo simulation. Med Phys. 2015 Jul; 42(7):4199-210. PMID: 26133619; PMCID: PMC4474955.
    9. Polster L, Schuemann J, Rinaldi I, Burigo L, McNamara AL, Stewart RD, Attili A, Carlson DJ, Sato T, Ramos Méndez J, Faddegon B, Perl J, Paganetti H. Extension of TOPAS for the simulation of proton radiation effects considering molecular and cellular endpoints. Phys Med Biol. 2015 Jul 07; 60(13):5053-70. PMID: 26061666; PMCID: PMC4511084.
    10. Shiao SL, Ruffell B, DeNardo DG, Faddegon BA, Park CC, Coussens LM. TH2-Polarized CD4(+) T Cells and Macrophages Limit Efficacy of Radiotherapy. Cancer Immunol Res. 2015 May; 3(5):518-25. PMID: 25716473; PMCID: PMC4420686.
    11. Ramos-Méndez J, Perl J, Faddegon B, Schümann J, Paganetti H. Geometrical splitting technique to improve the computational efficiency in Monte Carlo calculations for proton therapy. Med Phys. 2013 Apr; 40(4):041718. PMID: 23556888; PMCID: PMC3618101.
    12. Choi G, Huang B, Pinarbasi E, Braunstein SE, Horvai AE, Kogan S, Bhatia S, Faddegon B, Nakamura JL. Genetically mediated Nf1 loss in mice promotes diverse radiation-induced tumors modeling second malignant neoplasms. Cancer Res. 2012 Dec 15; 72(24):6425-34. PMID: 23071067; PMCID: PMC3787120.
    13. Schreiber EC, Sawkey DL, Faddegon BA. Sensitivity analysis of an asymmetric Monte Carlo beam model of a Siemens Primus accelerator. J Appl Clin Med Phys. 2012 Mar 08; 13(2):3402. PMID: 22402376.
      View in: PubMed
    14. O'Shea TP, Ge Y, Foley MJ, Faddegon BA. Characterization of an extendable multi-leaf collimator for clinical electron beams. Phys Med Biol. 2011 Dec 07; 56(23):7621-38. PMID: 22086242.
      View in: PubMed
    15. Ge Y, Faddegon BA. Study of intensity-modulated photon-electron radiation therapy using digital phantoms. Phys Med Biol. 2011 Oct 21; 56(20):6693-708. PMID: 21965269.
      View in: PubMed
    16. O'Shea TP, Foley MJ, Faddegon BA. Accounting for the fringe magnetic field from the bending magnet in a Monte Carlo accelerator treatment head simulation. Med Phys. 2011 Jun; 38(6):3260-9. PMID: 21815400.
      View in: PubMed
    17. Nakamura JL, Phong C, Pinarbasi E, Kogan SC, Vandenberg S, Horvai AE, Faddegon BA, Fiedler D, Shokat K, Houseman BT, Chao R, Pieper RO, Shannon K. Dose-dependent effects of focal fractionated irradiation on secondary malignant neoplasms in Nf1 mutant mice. Cancer Res. 2011 Jan 01; 71(1):106-15. PMID: 21199799; PMCID: PMC3077533.
    18. Halabi T, Faddegon B. Practical quantitative measurement of graticule misalignment relative to collimator axis of rotation. J Appl Clin Med Phys. 2010 Aug 15; 11(4):3318. PMID: 21081892.
      View in: PubMed
    19. O'Shea TP, Sawkey DL, Foley MJ, Faddegon BA. Monte Carlo commissioning of clinical electron beams using large field measurements. Phys Med Biol. 2010 Jul 21; 55(14):4083-105. PMID: 20601775.
      View in: PubMed
    20. Faddegon BA, Aubin M, Bani-Hashemi A, Gangadharan B, Gottschalk AR, Morin O, Sawkey D, Wu V, Yom SS. Comparison of patient megavoltage cone beam CT images acquired with an unflattened beam from a carbon target and a flattened treatment beam. Med Phys. 2010 Apr; 37(4):1737-41. PMID: 20443494.
      View in: PubMed
    21. Fragoso M, Kawrakow I, Faddegon BA, Solberg TD, Chetty IJ. Fast, accurate photon beam accelerator modeling using BEAMnrc: a systematic investigation of efficiency enhancing methods and cross-section data. Med Phys. 2009 Dec; 36(12):5451-66. PMID: 20095258; PMCID: PMC2787063.
    22. Faddegon BA, Sawkey D, O'Shea T, McEwen M, Ross C. Treatment head disassembly to improve the accuracy of large electron field simulation. Med Phys. 2009 Oct; 36(10):4577-91. PMID: 19928089; PMCID: PMC2771714.
    23. Faddegon BA, Kawrakow I, Kubyshin Y, Perl J, Sempau J, Urban L. The accuracy of EGSnrc, Geant4 and PENELOPE Monte Carlo systems for the simulation of electron scatter in external beam radiotherapy. Phys Med Biol. 2009 Oct 21; 54(20):6151-63. PMID: 19779217; PMCID: PMC3462739.
    24. Chen J, Irion J, Faddegon BA. Validation of the final aperture superposition technique to calculate electron output factors and depth dose curves. Med Phys. 2009 Aug; 36(8):3397-405. PMID: 19746772.
      View in: PubMed
    25. Beltran C, Lukose R, Gangadharan B, Bani-Hashemi A, Faddegon BA. Image quality & dosimetric property of an investigational imaging beam line MV-CBCT. J Appl Clin Med Phys. 2009 Jun 17; 10(3):3023. PMID: 19692984.
      View in: PubMed
    26. Maltz JS, Gangadharan B, Bose S, Hristov DH, Faddegon BA, Paidi A, Bani-Hashemi AR. Algorithm for X-ray scatter, beam-hardening, and beam profile correction in diagnostic (kilovoltage) and treatment (megavoltage) cone beam CT. IEEE Trans Med Imaging. 2008 Dec; 27(12):1791-810. PMID: 19033095.
      View in: PubMed
    27. Faddegon BA, Wu V, Pouliot J, Gangadharan B, Bani-Hashemi A. Low dose megavoltage cone beam computed tomography with an unflattened 4 MV beam from a carbon target. Med Phys. 2008 Dec; 35(12):5777-86. PMID: 19175135.
      View in: PubMed
    28. Faddegon BA, Asai M, Perl J, Ross C, Sempau J, Tinslay J, Salvat F. Benchmarking of Monte Carlo simulation of bremsstrahlung from thick targets at radiotherapy energies. Med Phys. 2008 Oct; 35(10):4308-17. PMID: 18975676; PMCID: PMC2736754.
    29. Maltz JS, Gangadharan B, Vidal M, Paidi A, Bose S, Faddegon BA, Aubin M, Morin O, Pouliot J, Zheng Z, Svatos MM, Bani-Hashemi AR. Focused beam-stop array for the measurement of scatter in megavoltage portal and cone beam CT imaging. Med Phys. 2008 Jun; 35(6):2452-62. PMID: 18649478.
      View in: PubMed
    30. Janssen RW, Faddegon BA, Dries WJ. Prototyping a large field size IORT applicator for a mobile linear accelerator. Phys Med Biol. 2008 Apr 21; 53(8):2089-102. PMID: 18369280.
      View in: PubMed
    31. Faddegon BA, Perl J, Asai M. Monte Carlo simulation of large electron fields. Phys Med Biol. 2008 Mar 07; 53(5):1497-510. PMID: 18296775; PMCID: PMC2900835.
    32. Chetty IJ, Curran B, Cygler JE, DeMarco JJ, Ezzell G, Faddegon BA, Kawrakow I, Keall PJ, Liu H, Ma CM, Rogers DW, Seuntjens J, Sheikh-Bagheri D, Siebers JV. Report of the AAPM Task Group No. 105: Issues associated with clinical implementation of Monte Carlo-based photon and electron external beam treatment planning. Med Phys. 2007 Dec; 34(12):4818-53. PMID: 18196810.
      View in: PubMed
    33. Ozawa T, Faddegon BA, Hu LJ, Bollen AW, Lamborn KR, Deen DF. Response of intracerebral human glioblastoma xenografts to multifraction radiation exposures. Int J Radiat Oncol Biol Phys. 2006 Sep 01; 66(1):263-70. PMID: 16904526.
      View in: PubMed
    34. Beddar AS, Biggs PJ, Chang S, Ezzell GA, Faddegon BA, Hensley FW, Mills MD. Intraoperative radiation therapy using mobile electron linear accelerators: report of AAPM Radiation Therapy Committee Task Group No. 72. Med Phys. 2006 May; 33(5):1476-89. PMID: 16752582.
      View in: PubMed
    35. Coleman J, Park C, Villarreal-Barajas JE, Petti P, Faddegon B. A comparison of Monte Carlo and Fermi-Eyges-Hogstrom estimates of heart and lung dose from breast electron boost treatment. Int J Radiat Oncol Biol Phys. 2005 Feb 01; 61(2):621-8. PMID: 15667984.
      View in: PubMed
    36. Hogstrom KR, Boyd RA, Antolak JA, Svatos MM, Faddegon BA, Rosenman JG. Dosimetry of a prototype retractable eMLC for fixed-beam electron therapy. Med Phys. 2004 Mar; 31(3):443-62. PMID: 15070241.
      View in: PubMed
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