Bruce Faddegon, PhD

Title(s)Professor, Radiation Oncology
SchoolSchool of Medicine
Address2340 Sutter Street, #H1008
San Francisco CA 94115
ORCID ORCID Icon0000-0002-4573-1582 Additional info
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    Collapse Biography 
    Collapse Education and Training
    University of Victoria, Victoria, BC, CanadaB.Sc.4/1977Physics (honors)
    University of British Columbia, Vancouver, BC, CanadaM.Sc.5/1983Physics (radiobiology)
    Carleton University, Ottawa, CanadaPh.D.9/1990Physics (radiotherapy)

    Collapse Overview 
    Collapse Overview
    Dr. Faddegon is a board certified clinical medical physics who is internationally recognized for his research in developing and using Monte Carlo methods for treatment head simulation and dose calculation and his development of new technology to improve accuracy and precision in radiotherapy. The overall objective of Dr. Faddegon’s research is to allow for more aggressive treatment in sites where side effects, local control, and even metastases are a problem through cost-effective solutions to improve the therapeutic ratio.

    Current research includes developing TOPAS, the Tool for Particle Simulation, a collaboration of UCSF, MGH and SLAC supported by NIH to improve advanced simulation of radiotherapy in conjunction with the open source Geant4 Monte Carlo simulation toolkit. The initial grant focussed on proton therapy. The renewal grant focused on organ and cell radiobiology. The current NIH U24 grant is through the NCI Informatics Technology for Cancer Research (ITCR) to extend TOPAS to conventional radiotherapy and imaging. Work in parallel is being done to develop TOPAS-nBio with enhanced track structure simulation capabilities in conjunction with Geant4-DNA for physicists, chemists and biologists to better establish the relationship between ionization deposition details, radiation chemistry, and biological effect.

    Dr. Faddegons clinical responsibility is physics support of radiotherapy. This includes installation, commissioning, maintenance and quality assurance of equipment and procedures used in radiation treatment planning and delivery. Highlights of Dr. Faddegon’s published clinical development work at UCSF include developing new x-ray targets that are implemented on linacs worldwide for low-dose megavoltage imaging and to reduce downtime, developing the means to treat the whole body over a short distance (3 meters), implementing high precision graticules for patient localization, and determining the means to detect and correct defective circuitry in treatments using virtual wedges.

    Collapse Research 
    Collapse Research Activities and Funding
    The TOPAS Tool for Particle Simulation, a Monte Carlo Simulation Tool for Physics, Biology and Clinical Research
    NIH U24CA215123Jun 4, 2018 - May 31, 2023
    Role: Principal Investigator
    PRISM: Precision Radiotherapy and Imaging of Small Mammals
    NIH S10OD021818Apr 15, 2017 - Apr 14, 2018
    Role: Principal Investigator
    TOPAS-nBio, A Monte Carlo tool for radiation biology research
    NIH R01 CA187003Apr 1, 2015 - Mar 31, 2025
    Role: Co-Investigator
    NAPTA: Optimizing clinical trial design & delivery of particle therapy for cancer
    NIH P20CA183640Feb 10, 2015 - Apr 30, 2018
    Role: Co-Investigator
    TOPAS: Fast and Easy Monte Carlo System for Proton Therapy
    NIH R01CA140735Jun 1, 2009 - May 31, 2016
    Role: Co-Investigator
    Accurate, easy-to-commission radiotherapy beam models
    NIH R01CA104777Jul 1, 2005 - Jun 30, 2009
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Creating uniform cluster dose spread-out Bragg peaks for proton and carbon beams. Med Phys. 2024 Feb 20. Ortiz R, Faddegon B. PMID: 38376446.
      View in: PubMed   Mentions:    Fields:    
    2. A digital male pelvis phantom series showing anatomical variations over the course of fractionated radiotherapy treatment. Med Phys. 2024 Apr; 51(4):3034-3044. Faddegon B, Descovich M, Chen K, Ramos-Méndez J, Iii MR, Wahl N, Taylor P, Griffin K, Lee C. PMID: 38071746.
      View in: PubMed   Mentions:    Fields:    
    3. Ionization detail parameters and cluster dose: a mathematical model for selection of nanodosimetric quantities for use in treatment planning in charged particle radiotherapy. Phys Med Biol. 2023 08 14; 68(17). Faddegon B, Blakely EA, Burigo L, Censor Y, Dokic I, Domínguez Kondo N, Ortiz R, Ramos Méndez J, Rucinski A, Schubert K, Wahl N, Schulte R. PMID: 37489619; PMCID: PMC10565507.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    4. An integrated Monte Carlo track-structure simulation framework for modeling inter and intra-track effects on homogenous chemistry. Phys Med Biol. 2023 Jun 09; 68(12). D-Kondo JN, Garcia-Garcia OR, LaVerne JA, Faddegon B, Schuemann J, Shin WG, Ramos-Méndez J. PMID: 37201533; PMCID: PMC10355172.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    5. TOPAS-imaging: extensions to the TOPAS simulation toolkit for medical imaging systems. Phys Med Biol. 2023 04 03; 68(8). Lee H, Cheon BW, Feld JW, Grogg K, Perl J, Ramos-Méndez JA, Faddegon B, Min CH, Paganetti H, Schuemann J. PMID: 36930985; PMCID: PMC10164408.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    6. Impact of DNA Geometry and Scoring on Monte Carlo Track-Structure Simulations of Initial Radiation-Induced Damage. Radiat Res. 2022 09 01; 198(3):207-220. Bertolet A, Ramos-Méndez J, McNamara A, Yoo D, Ingram S, Henthorn N, Warmenhoven JW, Faddegon B, Merchant M, McMahon SJ, Paganetti H, Schuemann J. PMID: 35767729; PMCID: PMC9458623.
      View in: PubMed   Mentions: 5     Fields:    
    7. TOPAS-nBio simulation of temperature-dependent indirect DNA strand break yields. Phys Med Biol. 2022 07 08; 67(14). Ramos-Méndez J, García-García O, Domínguez-Kondo J, LaVerne JA, Schuemann J, Moreno-Barbosa E, Faddegon B. PMID: 35714599; PMCID: PMC9512025.
      View in: PubMed   Mentions: 3     Fields:    
    8. DNA damage modeled with Geant4-DNA: effects of plasmid DNA conformation and experimental conditions. Phys Med Biol. 2021 12 15; 66(24). D-Kondo N, Moreno-Barbosa E, Štephán V, Stefanová K, Perrot Y, Villagrasa C, Incerti S, De Celis Alonso B, Schuemann J, Faddegon B, Ramos-Méndez J. PMID: 34787099.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    9. TOPAS-nBio validation for simulating water radiolysis and DNA damage under low-LET irradiation. Phys Med Biol. 2021 09 03; 66(17). Ramos-Méndez J, LaVerne JA, Domínguez-Kondo N, Milligan J, Štepán V, Stefanová K, Perrot Y, Villagrasa C, Shin WG, Incerti S, McNamara A, Paganetti H, Perl J, Schuemann J, Faddegon B. PMID: 34412044; PMCID: PMC8639218.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    10. Publisher's Note: "Dispersion calibration for the National Ignition Facility electron-positron-proton spectrometers for intense laser matter interactions" [Rev. Sci. Instrum. 92, 033516 (2021)]. Rev Sci Instrum. 2021 May 01; 92(5):059902. von der Linden J, Ramos-Mendez J, Faddegon B, Massin D, Fiksel G, Holder JP, Willingale L, Peebles J, Edwards MR, Chen H. PMID: 34243233.
      View in: PubMed   Mentions:    Fields:    
    11. Dispersion calibration for the National Ignition Facility electron-positron-proton spectrometers for intense laser matter interactions. Rev Sci Instrum. 2021 Mar 01; 92(3):033516. von der Linden J, Ramos-Méndez J, Faddegon B, Massin D, Fiksel G, Holder JP, Willingale L, Peebles J, Edwards MR, Chen H. PMID: 33820046.
      View in: PubMed   Mentions:    Fields:    
    12. Assessment of DNA damage with an adapted independent reaction time approach implemented in Geant4-DNA for the simulation of diffusion-controlled reactions between radio-induced reactive species and a chromatin fiber. Med Phys. 2021 Feb; 48(2):890-901. Tran HN, Ramos-Méndez J, Shin WG, Perrot Y, Faddegon B, Okada S, Karamitros M, Davídková M, Štepán V, Incerti S, Villagrasa C. PMID: 33232522; PMCID: PMC7986154.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    13. Report on G4-Med, a Geant4 benchmarking system for medical physics applications developed by the Geant4 Medical Simulation Benchmarking Group. Med Phys. 2021 Jan; 48(1):19-56. Arce P, Bolst D, Bordage MC, Brown JMC, Cirrone P, Cortés-Giraldo MA, Cutajar D, Cuttone G, Desorgher L, Dondero P, Dotti A, Faddegon B, Fedon C, Guatelli S, Incerti S, Ivanchenko V, Konstantinov D, Kyriakou I, Latyshev G, Le A, Mancini-Terracciano C, Maire M, Mantero A, Novak M, Omachi C, Pandola L, Perales A, Perrot Y, Petringa G, Quesada JM, Ramos-Méndez J, Romano F, Rosenfeld AB, Sarmiento LG, Sakata D, Sasaki T, Sechopoulos I, Simpson EC, Toshito T, Wright DH. PMID: 32392626; PMCID: PMC8054528.
      View in: PubMed   Mentions: 19     Fields:    
    14. Independent reaction times method in Geant4-DNA: Implementation and performance. Med Phys. 2020 Nov; 47(11):5919-5930. Ramos-Méndez J, Shin WG, Karamitros M, Domínguez-Kondo J, Tran NH, Incerti S, Villagrasa C, Perrot Y, Štepán V, Okada S, Moreno-Barbosa E, Faddegon B. PMID: 32970844; PMCID: PMC7891885.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    15. LET-Dependent Intertrack Yields in Proton Irradiation at Ultra-High Dose Rates Relevant for FLASH Therapy. Radiat Res. 2020 10 02; 194(4):351-362. Ramos-Méndez J, Domínguez-Kondo N, Schuemann J, McNamara A, Moreno-Barbosa E, Faddegon B. PMID: 32857855; PMCID: PMC7644138.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    16. A Millimeter-scale Single Charged Particle Dosimeter for Cancer Radiotherapy. IEEE J Solid-State Circuits. 2020 Nov; 55(11):2947-2958. Lee K, Scholey J, Norman EB, Daftari IK, Mishra KK, Faddegon BA, Maharbiz MM, Anwar M. PMID: 33281206; PMCID: PMC7709948.
      View in: PubMed   Mentions:
    17. Monte Carlo track-structure for the radionuclide Copper-64: characterization of S-values, nanodosimetry and quantification of direct damage to DNA. Phys Med Biol. 2020 07 27; 65(15):155005. Carrasco-Hernández J, Ramos-Méndez J, Faddegon B, Jalilian AR, Moranchel M, Ávila-Rodríguez MA. PMID: 32303013; PMCID: PMC7757752.
      View in: PubMed   Mentions: 4     Fields:    
    18. Cellular Response to Proton Irradiation: A Simulation Study with TOPAS-nBio. Radiat Res. 2020 07 08; 194(1):9-21. Zhu H, McNamara AL, McMahon SJ, Ramos-Mendez J, Henthorn NT, Faddegon B, Held KD, Perl J, Li J, Paganetti H, Schuemann J. PMID: 32401689; PMCID: PMC7484135.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    19. A parameter sensitivity study for simulating DNA damage after proton irradiation using TOPAS-nBio. Phys Med Biol. 2020 04 23; 65(8):085015. Zhu H, McNamara AL, Ramos-Mendez J, McMahon SJ, Henthorn NT, Faddegon B, Held KD, Perl J, Li J, Paganetti H, Schuemann J. PMID: 32101803; PMCID: PMC7748977.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    20. The TOPAS tool for particle simulation, a Monte Carlo simulation tool for physics, biology and clinical research. Phys Med. 2020 Apr; 72:114-121. Faddegon B, Ramos-Méndez J, Schuemann J, McNamara A, Shin J, Perl J, Paganetti H. PMID: 32247964; PMCID: PMC7192305.
      View in: PubMed   Mentions: 33     Fields:    Translation:Humans
    21. Beam modeling and beam model commissioning for Monte Carlo dose calculation-based radiation therapy treatment planning: Report of AAPM Task Group 157. Med Phys. 2020 Jan; 47(1):e1-e18. Ma CMC, Chetty IJ, Deng J, Faddegon B, Jiang SB, Li J, Seuntjens J, Siebers JV, Traneus E. PMID: 31679157.
      View in: PubMed   Mentions: 12     Fields:    
    22. Three discipline collaborative radiation therapy (3DCRT) special debate: The United States needs at least one carbon ion facility. J Appl Clin Med Phys. 2019 Nov; 20(11):6-13. Blakely EA, Faddegon B, Tinkle C, Bloch C, Dominello M, Griffin RJ, Joiner MC, Burmeister J. PMID: 31573146; PMCID: PMC6839391.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    23. Monte Carlo Processing on a Chip (MCoaC)-preliminary experiments toward the realization of optimal-hardware for TOPAS/Geant4 to drive discovery. Phys Med. 2019 Aug; 64:166-173. Abhyankar YS, Dev S, Sarun OS, Saxena A, Joshi R, Darbari H, Sajish C, Sonavane UB, Gavane V, Deshpande A, Dixit T, Harsh R, Badwe R, Rath GK, Laskar S, Faddegon B, Perl J, Paganetti H, Schuemann J, Srivastava A, Obcemea C, Nath AK, Sharma A, Buchsbaum J. PMID: 31515016; PMCID: PMC7238758.
      View in: PubMed   Mentions: 1     Fields:    
    24. The microdosimetric extension in TOPAS: development and comparison with published data. Phys Med Biol. 2019 07 11; 64(14):145004. Zhu H, Chen Y, Sung W, McNamara AL, Tran LT, Burigo LN, Rosenfeld AB, Li J, Faddegon B, Schuemann J, Paganetti H. PMID: 31117056; PMCID: PMC7182072.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    25. TOPAS-nBio: An Extension to the TOPAS Simulation Toolkit for Cellular and Sub-cellular Radiobiology. Radiat Res. 2019 02; 191(2):125-138. Schuemann J, McNamara AL, Ramos-Méndez J, Perl J, Held KD, Paganetti H, Incerti S, Faddegon B. PMID: 30609382; PMCID: PMC6377808.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansCells
    26. Simultaneous optimization of RBE-weighted dose and nanometric ionization distributions in treatment planning with carbon ions. Phys Med Biol. 2019 01 04; 64(1):015015. Burigo LN, Ramos-Méndez J, Bangert M, Schulte RW, Faddegon B. PMID: 30523890; PMCID: PMC7164666.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    27. Fast calculation of nanodosimetric quantities in treatment planning of proton and ion therapy. Phys Med Biol. 2018 Nov 28; 63(23):235015. Ramos-Méndez J, Burigo LN, Schulte R, Chuang C, Faddegon B. PMID: 30484432; PMCID: PMC8691449.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    28. A New Standard DNA Damage (SDD) Data Format. Radiat Res. 2019 01; 191(1):76-92. Schuemann J, McNamara AL, Warmenhoven JW, Henthorn NT, Kirkby KJ, Merchant MJ, Ingram S, Paganetti H, Held KD, Ramos-Mendez J, Faddegon B, Perl J, Goodhead DT, Plante I, Rabus H, Nettelbeck H, Friedland W, Kundrát P, Ottolenghi A, Baiocco G, Barbieri S, Dingfelder M, Incerti S, Villagrasa C, Bueno M, Bernal MA, Guatelli S, Sakata D, Brown JMC, Francis Z, Kyriakou I, Lampe N, Ballarini F, Carante MP, Davídková M, Štepán V, Jia X, Cucinotta FA, Schulte R, Stewart RD, Carlson DJ, Galer S, Kuncic Z, Lacombe S, Milligan J, Cho SH, Sawakuchi G, Inaniwa T, Sato T, Li W, Solov'yov AV, Surdutovich E, Durante M, Prise KM, McMahon SJ. PMID: 30407901; PMCID: PMC6407706.
      View in: PubMed   Mentions: 24     Fields:    Translation:Cells
    29. Clinical trials involving carbon-ion radiation therapy and the path forward. Cancer. 2018 12 01; 124(23):4467-4476. Lazar AA, Schulte R, Faddegon B, Blakely EA, Roach M. PMID: 30307603; PMCID: PMC6540799.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    30. Geometrical structures for radiation biology research as implemented in the TOPAS-nBio toolkit. Phys Med Biol. 2018 09 06; 63(17):175018. McNamara AL, Ramos-Méndez J, Perl J, Held K, Dominguez N, Moreno E, Henthorn NT, Kirkby KJ, Meylan S, Villagrasa C, Incerti S, Faddegon B, Paganetti H, Schuemann J. PMID: 30088810; PMCID: PMC6176684.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    31. Helium CT: Monte Carlo simulation results for an ideal source and detector with comparison to proton CT. Med Phys. 2018 Jul; 45(7):3264-3274. Piersimoni P, Faddegon BA, Méndez JR, Schulte RW, Volz L, Seco J. PMID: 29727481; PMCID: PMC8145780.
      View in: PubMed   Mentions: 6     Fields:    
    32. Monte Carlo simulation of chemistry following radiolysis with TOPAS-nBio. Phys Med Biol. 2018 05 17; 63(10):105014. Ramos-Méndez J, Perl J, Schuemann J, McNamara A, Paganetti H, Faddegon B. PMID: 29697057; PMCID: PMC6027650.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    33. Flagged uniform particle splitting for variance reduction in proton and carbon ion track-structure simulations. Phys Med Biol. 2017 Jul 06; 62(15):5908-5925. Ramos-Méndez J, Schuemann J, Incerti S, Paganetti H, Schulte R, Faddegon B. PMID: 28594336; PMCID: PMC5785278.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    34. The effect of beam purity and scanner complexity on proton CT accuracy. Med Phys. 2017 Jan; 44(1):284-298. Piersimoni P, Ramos-Méndez J, Geoghegan T, Bashkirov VA, Schulte RW, Faddegon BA. PMID: 28066887; PMCID: PMC5362942.
      View in: PubMed   Mentions: 9     Fields:    
    35. Validation of the radiobiology toolkit TOPAS-nBio in simple DNA geometries. Phys Med. 2017 Jan; 33:207-215. McNamara A, Geng C, Turner R, Mendez JR, Perl J, Held K, Faddegon B, Paganetti H, Schuemann J. PMID: 28017738; PMCID: PMC5292291.
      View in: PubMed   Mentions: 26     Fields:    Translation:Cells
    36. Technical Note: Preferred dosimeter size and associated correction factors in commissioning high dose per pulse, flattening filter free x-ray beams. Med Phys. 2016 Mar; 43(3):1507-13. Sudhyadhom A, Kirby N, Faddegon B, Chuang CF. PMID: 26936734.
      View in: PubMed   Mentions: 2     Fields:    
    37. New Clinical and Research Programs in Particle Beam Radiation Therapy: The University of California San Francisco Perspective. Int J Part Ther. 2016; 2(3):471-473. Roach M, Schulte R, Mishra K, Faddegon B, Barani I, Lazar A, Blakely EA. PMID: 27099866; PMCID: PMC4834449.
      View in: PubMed   Mentions: 4  
    38. Dose assessment for the fetus considering scattered and secondary radiation from photon and proton therapy when treating a brain tumor of the mother. Phys Med Biol. 2016 Jan 21; 61(2):683-95. Geng C, Moteabbed M, Seco J, Gao Y, Xu XG, Ramos-Méndez J, Faddegon B, Paganetti H. PMID: 26716718.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    39. Experimental depth dose curves of a 67.5 MeV proton beam for benchmarking and validation of Monte Carlo simulation. Med Phys. 2015 Jul; 42(7):4199-210. Faddegon BA, Shin J, Castenada CM, Ramos-Méndez J, Daftari IK. PMID: 26133619; PMCID: PMC4474955.
      View in: PubMed   Mentions: 5     Fields:    Translation:PHPublic Health
    40. Extension of TOPAS for the simulation of proton radiation effects considering molecular and cellular endpoints. Phys Med Biol. 2015 Jul 07; 60(13):5053-70. Polster L, Schuemann J, Rinaldi I, Burigo L, McNamara AL, Stewart RD, Attili A, Carlson DJ, Sato T, Ramos Méndez J, Faddegon B, Perl J, Paganetti H. PMID: 26061666; PMCID: PMC4511084.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    41. Improved efficiency in Monte Carlo simulation for passive-scattering proton therapy. Phys Med Biol. 2015 Jul 07; 60(13):5019-35. Méndez JR, Perl J, Schümann J, Shin J, Paganetti H, Faddegon B. PMID: 26061457; PMCID: PMC4498399.
      View in: PubMed   Mentions: 2     Fields:    
    42. A framework for implementation of organ effect models in TOPAS with benchmarks extended to proton therapy. Phys Med Biol. 2015 Jul 07; 60(13):5037-52. Ramos-Méndez J, Perl J, Schümann J, Shin J, Paganetti H, Faddegon B. PMID: 26061583; PMCID: PMC4498397.
      View in: PubMed   Mentions: 2     Fields:    
    43. TH2-Polarized CD4(+) T Cells and Macrophages Limit Efficacy of Radiotherapy. Cancer Immunol Res. 2015 May; 3(5):518-25. Shiao SL, Ruffell B, DeNardo DG, Faddegon BA, Park CC, Coussens LM. PMID: 25716473; PMCID: PMC4420686.
      View in: PubMed   Mentions: 124     Fields:    Translation:AnimalsCells
    44. Experimental validation of the TOPAS Monte Carlo system for passive scattering proton therapy. Med Phys. 2013 Dec; 40(12):121719. Testa M, Schümann J, Lu HM, Shin J, Faddegon B, Perl J, Paganetti H. PMID: 24320505; PMCID: PMC4109425.
      View in: PubMed   Mentions: 35     Fields:    Translation:Humans
    45. Geometrical splitting technique to improve the computational efficiency in Monte Carlo calculations for proton therapy. Med Phys. 2013 Apr; 40(4):041718. Ramos-Méndez J, Perl J, Faddegon B, Schümann J, Paganetti H. PMID: 23556888; PMCID: PMC3618101.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    46. TOPAS: an innovative proton Monte Carlo platform for research and clinical applications. Med Phys. 2012 Nov; 39(11):6818-37. Perl J, Shin J, Schumann J, Faddegon B, Paganetti H. PMID: 23127075; PMCID: PMC3493036.
      View in: PubMed   Mentions: 217     Fields:    Translation:Humans
    47. Genetically mediated Nf1 loss in mice promotes diverse radiation-induced tumors modeling second malignant neoplasms. Cancer Res. 2012 Dec 15; 72(24):6425-34. Choi G, Huang B, Pinarbasi E, Braunstein SE, Horvai AE, Kogan S, Bhatia S, Faddegon B, Nakamura JL. PMID: 23071067; PMCID: PMC3787120.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    48. SU-E-T-500: Pencil-Beam versus Monte Carlo Based Dose Calculation for Proton Therapy Patients with Complex Geometries. Clinical Use of the TOPAS Monte Carlo System. Med Phys. 2012 Jun; 39(6Part18):3820. Schuemann J, Shin J, Perl J, Grassberger C, Verburg J, Faddegon B, Paganetti H. PMID: 28518479.
      View in: PubMed   Mentions: 3     Fields:    
    49. SU-E-T-478: Geometrical Splitting Technique to Improve the Computational Efficiency in Monte Carlo Calculations for Proton Therapy. Med Phys. 2012 Jun; 39(6Part17):3815. Ramos-Mendez J, Perl J, Faddegon B, Paganetti H. PMID: 28517444.
      View in: PubMed   Mentions:    Fields:    
    50. SU-E-T-473: Performance Assessment of the TOPAS Tool for Particle Simulation for Proton Therapy Applications. Med Phys. 2012 Jun; 39(6Part17):3814. Perl J, Shin J, Schuemann J, Faddegon B, Paganetti H. PMID: 28517451.
      View in: PubMed   Mentions:    Fields:    
    51. Efficient voxel navigation for proton therapy dose calculation in TOPAS and Geant4. Phys Med Biol. 2012 Jun 07; 57(11):3281-93. Schümann J, Paganetti H, Shin J, Faddegon B, Perl J. PMID: 22572154; PMCID: PMC3367506.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    52. A modular method to handle multiple time-dependent quantities in Monte Carlo simulations. Phys Med Biol. 2012 Jun 07; 57(11):3295-308. Shin J, Perl J, Schümann J, Paganetti H, Faddegon BA. PMID: 22572201; PMCID: PMC4477630.
      View in: PubMed   Mentions: 10     Fields:    
    53. Sensitivity analysis of an asymmetric Monte Carlo beam model of a Siemens Primus accelerator. J Appl Clin Med Phys. 2012 Mar 08; 13(2):3402. Schreiber EC, Sawkey DL, Faddegon BA. PMID: 22402376; PMCID: PMC5716413.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    54. Characterization of an extendable multi-leaf collimator for clinical electron beams. Phys Med Biol. 2011 Dec 07; 56(23):7621-38. O'Shea TP, Ge Y, Foley MJ, Faddegon BA. PMID: 22086242.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    55. Study of intensity-modulated photon-electron radiation therapy using digital phantoms. Phys Med Biol. 2011 Oct 21; 56(20):6693-708. Ge Y, Faddegon BA. PMID: 21965269.
      View in: PubMed   Mentions: 1     Fields:    
    56. Accounting for the fringe magnetic field from the bending magnet in a Monte Carlo accelerator treatment head simulation. Med Phys. 2011 Jun; 38(6):3260-9. O'Shea TP, Foley MJ, Faddegon BA. PMID: 21815400.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    57. Dose-dependent effects of focal fractionated irradiation on secondary malignant neoplasms in Nf1 mutant mice. Cancer Res. 2011 Jan 01; 71(1):106-15. Nakamura JL, Phong C, Pinarbasi E, Kogan SC, Vandenberg S, Horvai AE, Faddegon BA, Fiedler D, Shokat K, Houseman BT, Chao R, Pieper RO, Shannon K. PMID: 21199799; PMCID: PMC3077533.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    58. Practical quantitative measurement of graticule misalignment relative to collimator axis of rotation. J Appl Clin Med Phys. 2010 Aug 15; 11(4):3318. Halabi T, Faddegon B. PMID: 21081892; PMCID: PMC5720415.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    59. Monte Carlo commissioning of clinical electron beams using large field measurements. Phys Med Biol. 2010 Jul 21; 55(14):4083-105. O'Shea TP, Sawkey DL, Foley MJ, Faddegon BA. PMID: 20601775.
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    60. Comparison of patient megavoltage cone beam CT images acquired with an unflattened beam from a carbon target and a flattened treatment beam. Med Phys. 2010 Apr; 37(4):1737-41. Faddegon BA, Aubin M, Bani-Hashemi A, Gangadharan B, Gottschalk AR, Morin O, Sawkey D, Wu V, Yom SS. PMID: 20443494.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    61. A diamond target for megavoltage cone-beam CT. Med Phys. 2010 Mar; 37(3):1246-53. Sawkey D, Lu M, Morin O, Aubin M, Yom SS, Gottschalk AR, Bani-Hashemi A, Faddegon BA. PMID: 20384262.
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    62. Fast, accurate photon beam accelerator modeling using BEAMnrc: a systematic investigation of efficiency enhancing methods and cross-section data. Med Phys. 2009 Dec; 36(12):5451-66. Fragoso M, Kawrakow I, Faddegon BA, Solberg TD, Chetty IJ. PMID: 20095258; PMCID: PMC2787063.
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    63. Simulation of large x-ray fields using independently measured source and geometry details. Med Phys. 2009 Dec; 36(12):5622-32. Sawkey D, Faddegon BA. PMID: 20095275; PMCID: PMC2792331.
      View in: PubMed   Mentions: 5     Fields:    
    64. Treatment head disassembly to improve the accuracy of large electron field simulation. Med Phys. 2009 Oct; 36(10):4577-91. Faddegon BA, Sawkey D, O'Shea T, McEwen M, Ross C. PMID: 19928089; PMCID: PMC2771714.
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    65. The accuracy of EGSnrc, Geant4 and PENELOPE Monte Carlo systems for the simulation of electron scatter in external beam radiotherapy. Phys Med Biol. 2009 Oct 21; 54(20):6151-63. Faddegon BA, Kawrakow I, Kubyshin Y, Perl J, Sempau J, Urban L. PMID: 19779217; PMCID: PMC3462739.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    66. Validation of the final aperture superposition technique to calculate electron output factors and depth dose curves. Med Phys. 2009 Aug; 36(8):3397-405. Chen J, Irion J, Faddegon BA. PMID: 19746772.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    67. Image quality & dosimetric property of an investigational imaging beam line MV-CBCT. J Appl Clin Med Phys. 2009 Jun 17; 10(3):37-48. Beltran C, Lukose R, Gangadharan B, Bani-Hashemi A, Faddegon BA. PMID: 19692984; PMCID: PMC5720554.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    68. Determination of electron energy, spectral width, and beam divergence at the exit window for clinical megavoltage x-ray beams. Med Phys. 2009 Mar; 36(3):698-707. Sawkey DL, Faddegon BA. PMID: 19378730; PMCID: PMC2673678.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    69. Low dose megavoltage cone beam computed tomography with an unflattened 4 MV beam from a carbon target. Med Phys. 2008 Dec; 35(12):5777-86. Faddegon BA, Wu V, Pouliot J, Gangadharan B, Bani-Hashemi A. PMID: 19175135.
      View in: PubMed   Mentions: 29     Fields:    Translation:Humans
    70. Algorithm for X-ray scatter, beam-hardening, and beam profile correction in diagnostic (kilovoltage) and treatment (megavoltage) cone beam CT. IEEE Trans Med Imaging. 2008 Dec; 27(12):1791-810. Maltz JS, Gangadharan B, Bose S, Hristov DH, Faddegon BA, Paidi A, Bani-Hashemi AR. PMID: 19033095.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    71. Benchmarking of Monte Carlo simulation of bremsstrahlung from thick targets at radiotherapy energies. Med Phys. 2008 Oct; 35(10):4308-17. Faddegon BA, Asai M, Perl J, Ross C, Sempau J, Tinslay J, Salvat F. PMID: 18975676; PMCID: PMC2736754.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    72. Measurement of multiple scattering of 13 and 20 MeV electrons by thin foils. Med Phys. 2008 Sep; 35(9):4121-31. Ross CK, McEwen MR, McDonald AF, Cojocaru CD, Faddegon BA. PMID: 18841865; PMCID: PMC2673663.
      View in: PubMed   Mentions: 6     Fields:    
    73. Sci-Fri PM: Planning-01: Measured electron and x-ray angular distribution data for benchmarking Monte Carlo codes. Med Phys. 2008 Jul; 35(7Part3):3412. Cojocaru CD, Ross CK, McEwen MR, McDonald AF, Faddegon BA. PMID: 28512874; PMCID: PMC7986574.
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    74. Focused beam-stop array for the measurement of scatter in megavoltage portal and cone beam CT imaging. Med Phys. 2008 Jun; 35(6):2452-62. Maltz JS, Gangadharan B, Vidal M, Paidi A, Bose S, Faddegon BA, Aubin M, Morin O, Pouliot J, Zheng Z, Svatos MM, Bani-Hashemi AR. PMID: 18649478.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    75. Prototyping a large field size IORT applicator for a mobile linear accelerator. Phys Med Biol. 2008 Apr 21; 53(8):2089-102. Janssen RW, Faddegon BA, Dries WJ. PMID: 18369280.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    76. Monte Carlo simulation of large electron fields. Phys Med Biol. 2008 Mar 07; 53(5):1497-510. Faddegon BA, Perl J, Asai M. PMID: 18296775; PMCID: PMC2900835.
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    77. Report of the AAPM Task Group No. 105: Issues associated with clinical implementation of Monte Carlo-based photon and electron external beam treatment planning. Med Phys. 2007 Dec; 34(12):4818-53. Chetty IJ, Curran B, Cygler JE, DeMarco JJ, Ezzell G, Faddegon BA, Kawrakow I, Keall PJ, Liu H, Ma CM, Rogers DW, Seuntjens J, Sheikh-Bagheri D, Siebers JV. PMID: 18196810.
      View in: PubMed   Mentions: 163     Fields:    Translation:Humans
    78. Response of intracerebral human glioblastoma xenografts to multifraction radiation exposures. Int J Radiat Oncol Biol Phys. 2006 Sep 01; 66(1):263-70. Ozawa T, Faddegon BA, Hu LJ, Bollen AW, Lamborn KR, Deen DF. PMID: 16904526.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    79. A pulse-rate dependence of dose per monitor unit and its significant effect on wedged-shaped fields delivered with variable dose rate and a moving jaw. Med Phys. 2006 Aug; 33(8):3063-5. Faddegon BA, Garde E. PMID: 16964884.
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    80. Intraoperative radiation therapy using mobile electron linear accelerators: report of AAPM Radiation Therapy Committee Task Group No. 72. Med Phys. 2006 May; 33(5):1476-89. Beddar AS, Biggs PJ, Chang S, Ezzell GA, Faddegon BA, Hensley FW, Mills MD. PMID: 16752582.
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    81. Final Aperture Superposition Technique applied to fast calculation of electron output factors and depth dose curves. Med Phys. 2005 Nov; 32(11):3286-94. Faddegon BA, Villarreal-Barajas JE. PMID: 16370417.
      View in: PubMed   Mentions: 1     Fields:    
    82. Monte Carlo simulation of large electron fields. Phys Med Biol. 2005 Mar 07; 50(5):741-53. Faddegon B, Schreiber E, Ding X. PMID: 15798251.
      View in: PubMed   Mentions: 8     Fields:    
    83. Sensitivity of large-field electron beams to variations in a Monte Carlo accelerator model. Phys Med Biol. 2005 Mar 07; 50(5):769-78. Schreiber EC, Faddegon BA. PMID: 15798253.
      View in: PubMed   Mentions: 7     Fields:    
    84. A comparison of Monte Carlo and Fermi-Eyges-Hogstrom estimates of heart and lung dose from breast electron boost treatment. Int J Radiat Oncol Biol Phys. 2005 Feb 01; 61(2):621-8. Coleman J, Park C, Villarreal-Barajas JE, Petti P, Faddegon B. PMID: 15667984.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    85. Dosimetry of a prototype retractable eMLC for fixed-beam electron therapy. Med Phys. 2004 Mar; 31(3):443-62. Hogstrom KR, Boyd RA, Antolak JA, Svatos MM, Faddegon BA, Rosenman JG. PMID: 15070241.
      View in: PubMed   Mentions: 18     Fields:    
    86. Comparison of beam characteristics of a gold x-ray target and a tungsten replacement target. Med Phys. 2004 Jan; 31(1):91-7. Faddegon B, Egley B, Steinberg T. PMID: 14761025.
      View in: PubMed   Mentions: 2     Fields:    
    87. Electron spectra derived from depth dose distributions. Med Phys. 2000 Mar; 27(3):514-26. Faddegon BA, Blevis I. PMID: 10757603.
      View in: PubMed   Mentions: 1     Fields:    
    88. The flatness of Siemens linear accelerator x-ray fields. Med Phys. 1999 Feb; 26(2):220-8. Faddegon BA, O'Brien P, Mason DL. PMID: 10076978.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    89. Megavoltage imaging with low Z targets: implementation and characterization of an investigational system. Med Phys. 1998 Oct; 25(10):1910-8. Ostapiak OZ, O'Brien PF, Faddegon BA. PMID: 9800698.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    90. Accurate characterization of Monte Carlo calculated electron beams for radiotherapy. Med Phys. 1997 Mar; 24(3):401-16. Ma CM, Faddegon BA, Rogers DW, Mackie TR. PMID: 9089592.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    91. Monte Carlo based phase-space evolution for electron dose calculation. Med Phys. 1997 Feb; 24(2):177-87. Scora D, Faddegon BA. PMID: 9048357.
      View in: PubMed   Mentions:    Fields:    
    92. Calculation of x-ray spectra for radiosurgical beams. Med Phys. 1995 Oct; 22(10):1657-61. Sixel KE, Faddegon BA. PMID: 8551991.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    93. BEAM: a Monte Carlo code to simulate radiotherapy treatment units. Med Phys. 1995 May; 22(5):503-24. Rogers DW, Faddegon BA, Ding GX, Ma CM, We J, Mackie TR. PMID: 7643786.
      View in: PubMed   Mentions: 188     Fields:    Translation:Humans
    94. Angular distribution of bremsstrahlung from 15-MeV electrons incident on thick targets of Be, Al, and Pb. Med Phys. 1991 Jul-Aug; 18(4):727-39. Faddegon BA, Ross CK, Rogers DW. PMID: 1921878.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    95. Forward-directed bremsstrahlung of 10- to 30-MeV electrons incident on thick targets of Al and Pb. Med Phys. 1990 Sep-Oct; 17(5):773-85. Faddegon BA, Ross CK, Rogers DW. PMID: 2233563.
      View in: PubMed   Mentions: 5     Fields:    
    96. Computer aided design and verification of megavoltage tissue compensators for oblique beams. Med Phys. 1988 Sep-Oct; 15(5):757-62. Faddegon BA, Pfalzner P. PMID: 3141758.
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    97. The effect of misonidazole as a hypoxic radiosensitizer at low dose. Radiat Res. 1984 Nov; 100(2):340-7. Palcic B, Faddegon B, Skarsgard LD. PMID: 6494445.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
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