Rosanna Wustrack, MD

Title(s)Associate Professor, Orthopaedic Surgery
SchoolSchool of Medicine
Address550 16th Street, #5403
San Francisco CA 94158
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    Collapse Biography 
    Collapse Education and Training
    Yale University, New Haven, CTBA 1999Biology
    Washington University in St. Louis Medical School, St. Louis, MOMD2006Medicine
    University of California San Francisco Department of Orthopedic Surgery, San Francisco, CAResidency2012Orthopedic Surgery
    Memorial Sloan Kettering Cancer Center, New York, NYFellowship2013Musculoskeletal Oncology
    University of California San Francisco, San Francisco, CACertificate2014Advanced Training in Clinical Research
    University of California, San Francisco, CA2018Diversity, Equity, and Inclusion Champion Training
    Collapse Awards and Honors
    UCSF Department of Orthopedic Surgery2012Mauer Chief Resident of the Year
    UCSF Department of Orthopedic Surgery2016James O. Johnston Resident Teaching Award
    UCSF RAP Grant Program2018  - 2019Identifying and enhancing the host immune response in adult soft tissue sarcoma
    UCSF Academy of Medical Educators2018Excellence in Teaching Award
    Musculoskeletal Research Society2019  - 2020Mentored Research Award
    UCSF Department of Orthopedic Surgery2020Compassionate Physician Award
    UCSF Muriel Steele Society2020Muriel Steele Society Honor Roll
    UCSF Health2020Exceptional Physician Award
    UCSF Muriel Steele Society2021  - 2022Muriel Steele Society Honor Roll

    Collapse Overview 
    Collapse Overview
    Dr. Rosanna Wustrack is the Chief of Orthopedic Oncology and an orthopedic surgeon who specializes in the surgical diagnosis and treatment of musculoskeletal tumors and fragility fractures. Her research focuses on immunotherapy for sarcomas, functional outcomes in cancer patients, osseointegration and optimizing treatment for metastatic disease. She also is interested in global health and osteoporosis in cancer survivors.

    Dr. Wustrack received an undergraduate degree from Yale University before earning a medical degree from Washington University School of Medicine in St. Louis. She completed an internship and residency in orthopedic surgery at UCSF. Subsequently, she completed fellowship training in musculoskeletal oncology at Memorial Sloan Kettering Cancer Center in New York.
    Collapse Global Health Equity

    Collapse Research 
    Collapse Research Activities and Funding
    Identifying and enhancing the host immune response in adult soft tissue sarcoma
    Musculoskeletal Tumor Society Jul 1, 2019 - Jun 30, 2021
    Role: Principal Investigator
    Description: The aim of this pilot grant is to determine the host immune response to common soft tissue sarcomas and determine which immune response is associated with a favorable outcome as measured by time to metastases and overall survival. We are analyzing the various tumor-infiltrating lymphocytes in fresh sarcoma tissue from resected specimens to determine the "immune profile" among soft tissue sarcomas. Additionally we will use this grant to develop an immune-competent sarcoma mouse model that we can then whether or not high intensity focused ultrasound treatment to the sarcoma can create a favorable immune response.
    An Osseo-Neural Transtibial Prosthesis with Efferent-Afferent Neural Control
    Department of Defense, United States Army Medical Research and Materiel Command W81XWH-19-1-0151Apr 15, 2019 - Apr 14, 2022
    Role: Co-Investigator
    Description: To evaluate the safety and functional outcomes of a bone-anchored, percutaneous prostheses exhibiting full volitional control over a neuro-mechanical prosthetic system where key walking metrics are normalized, including preferred speed, metabolism and joint dynamics.
    Transfemoral Amputee Osseointegration Study
    Department of Defense, United States Army Medical Research and Materiel Command W81XWH-17-2-0060, USAMRMC-BA160465Sep 30, 2017 - Oct 1, 2022
    Role: Co-Investigator
    Description: This is a prospective study evaluating the safety and efficacy as well as HRQL and functional outcomes as related to a bone-anchored percutaneous prosthesis system (OPRA) for transfemoral amputees. Patients will undergo a two-stage procedure to implant a titanium screw into the femur followed by bringing and abutment through the skin that the prosthesis can then attach. We will be measuring safety, complications, gait and general and disease specific HRQL outcomes.

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Osteosarcoma PDX-Derived Cell Line Models for Preclinical Drug Evaluation Demonstrate Metastasis Inhibition by Dinaciclib through a Genome-Targeted Approach. Clin Cancer Res. 2024 02 16; 30(4):849-864. Schott CR, Koehne AL, Sayles LC, Young EP, Luck C, Yu K, Lee AG, Breese MR, Leung SG, Xu H, Shah AT, Liu HY, Spillinger A, Behroozfard IH, Marini KD, Dinh PT, Pons Ventura MV, Vanderboon EN, Hazard FK, Cho SJ, Avedian RS, Mohler DG, Zimel M, Wustrack R, Curtis C, Sirota M, Sweet-Cordero EA. PMID: 37703185; PMCID: PMC10870121.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    2. ASPSCR1-TFE3 reprograms transcription by organizing enhancer loops around hexameric VCP/p97. Nat Commun. 2024 Feb 07; 15(1):1165. Pozner A, Li L, Verma SP, Wang S, Barrott JJ, Nelson ML, Yu JSE, Negri GL, Colborne S, Hughes CS, Zhu JF, Lambert SL, Carroll LS, Smith-Fry K, Stewart MG, Kannan S, Jensen B, John CM, Sikdar S, Liu H, Dang NH, Bourdage J, Li J, Vahrenkamp JM, Mortenson KL, Groundland JS, Wustrack R, Senger DL, Zemp FJ, Mahoney DJ, Gertz J, Zhang X, Lazar AJ, Hirst M, Morin GB, Nielsen TO, Shen PS, Jones KB. PMID: 38326311; PMCID: PMC10850509.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    3. ASPSCR1-TFE3 reprograms transcription by organizing enhancer loops around hexameric VCP/p97. bioRxiv. 2023 Oct 02. Pozner A, Verma SP, Li L, Wang S, Barrott JJ, Nelson ML, Yu JSE, Negri GL, Colborne S, Hughes CS, Zhu JF, Lambert SL, Carroll LS, Smith-Fry K, Stewart MG, Kannan S, Jensen B, Mortenson KL, John C, Sikdar S, Liu H, Dang NH, Bourdage J, Li J, Vahrenkamp JM, Groundland JS, Wustrack R, Senger DL, Zemp FJ, Mahoney DJ, Gertz J, Zhang X, Lazar AJ, Hirst M, Morin GB, Nielsen TO, Shen PS, Jones KB. PMID: 37873234; PMCID: PMC10592841.
      View in: PubMed   Mentions:
    4. Surgical Site Infection Is Not Associated with 1-Year Progression-Free Survival After Endoprosthetic Reconstruction for Lower-Extremity Osteosarcoma: A Secondary Analysis of PARITY Study Data. J Bone Joint Surg Am. 2023 07 19; 105(Suppl 1):49-56. Jackson KJ, Sullivan CD, Zimel MN, Wustrack RL, PARITY Investigators. PMID: 37466580.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    5. A Case of Hypercalcemia from PTHrP-Producing Fibromyxoid Sarcoma Responsive to Glucocorticoid Therapy. Calcif Tissue Int. 2023 08; 113(2):246-253. Niu I, Hsiao EC, Wustrack R, Wysolmerski JJ, Dann P, Masharani U. PMID: 37358786; PMCID: PMC10372127.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    6. Development and characterization of new patient-derived xenograft (PDX) models of osteosarcoma with distinct metastatic capacities. bioRxiv. 2023 Jan 20. Schott CR, Koehne AL, Sayles LC, Young EP, Luck C, Yu K, Lee AG, Breese MR, Leung SG, Xu H, Shah AT, Liu HY, Spillinger A, Behroozfard IH, Marini KD, Dinh PT, Pons Ventura MAV, Vanderboon EN, Hazard FK, Cho SJ, Avedian RS, Mohler DG, Zimel M, Wustrack R, Curtis C, Sirota M, Sweet-Cordero EA. PMID: 36711882; PMCID: PMC9882347.
      View in: PubMed   Mentions:
    7. PSAT208 A Case of Hypercalcemia From PTHrP-Producing Fibromyxoid Sarcoma Responsive to Glucocorticoid Therapy. Journal of the Endocrine Society. 2022 Nov 1; 6(Suppl 1):a212-a213. Niu NI, Hsiao HE, Wustrack WR, Wysolmerski WJ, Dann DP, Masharani MU. .
      View in: Publisher Site   Mentions:
    8. Survival and failure modes of the Compress® spindle and expandable distal femur endoprosthesis among pediatric patients: A multi-institutional study. J Surg Oncol. 2023 Jan; 127(1):148-158. Tanaka KS, Andaya VR, Thorpe SW, Gundle KR, Hayden JB, Duong YC, Avedian RS, Mohler DG, Morse LJ, Zimel MN, O'Donnell RJ, Fang A, Randall RL, Tran TH, New C, Wustrack RL, other members of Study Group FORCE. PMID: 36112398; PMCID: PMC10087226.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    9. What Are Risk Factors for and Outcomes of Late Amputation After Treatment for Lower Extremity Sarcoma: A Childhood Cancer Survivor Study Report. Clin Orthop Relat Res. 2023 03 01; 481(3):526-538. Geiger EJ, Liu W, Srivastava DK, Bernthal NM, Weil BR, Yasui Y, Ness KK, Krull KR, Goldsby RE, Oeffinger KC, Robison LL, Dieffenbach BV, Weldon CB, Gebhardt MC, Howell R, Murphy AJ, Leisenring WM, Armstrong GT, Chow EJ, Wustrack RL. PMID: 35583517; PMCID: PMC9928620.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    10. Survival of Patients With Primary Osseous Malignancies of the Mobile Spine Is Associated With Access to "Standard Treatment" Protocols. J Am Acad Orthop Surg. 2022 Sep 01; 30(17):841-850. Stroud SG, Geiger EJ, Lichtensztajn DY, Goldsby RE, Cheng I, Wustrack R, Theologis AA. PMID: 35507547.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    11. Malignant triton tumor in the setting of segmental neurofibromatosis: A rare case report and review of the literature. Interdisciplinary Neurosurgery. 2021 Jun 1; 24:101073. Jack JA, Witiw WC, Hockley HA, Huie HC, Wustrack WR, Jacques JL. .
      View in: Publisher Site   Mentions:
    12. Tumor morphology and location associate with immune cell composition in pleomorphic sarcoma. Cancer Immunol Immunother. 2021 Oct; 70(10):3031-3040. Wustrack RL, Shao E, Sheridan J, Zimel M, Cho SJ, Horvai AE, Luong D, Kwek SS, Fong L, Okimoto RA. PMID: 33864502; PMCID: PMC8423706.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    13. Innovations in Pediatric Prosthetics. Journal of the Pediatric Orthopaedic Society of North America. 2021 Feb 1; 3(1):221. Hall HM, Wustrack WR, Cummings CD, Welling WR, Kaleta KM, Koenig KK, Laine LJ, Morgan MS. .
      View in: Publisher Site   Mentions:
    14. En bloc excision of sacroiliac chondrosarcoma aided by 3D laser printed modeling and stereotactic navigation. J Clin Neurosci. 2021 Mar; 85:64-66. Guinn JMV, Mayer RR, Li B, Dang ABC, Dang A, Wustrack R, Chou D. PMID: 33581792.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    15. Complete Regression of Rhabdomyosarcoma in an Adult Secondary to Postoperative Wound Infection Following Limb Salvage Surgery: A Case Report. Perm J. 2020 12; 25:1. Fang AS, Morse LJ, Wustrack R, Huber R, Pan M. PMID: 33635775; PMCID: PMC8817904.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    16. Outcomes of Elderly Patients with Soft Tissue Sarcoma of the Extremities. International Journal of Radiation Oncology • Biology • Physics. 2020 Nov 1; 108(3):e6. Chew CJ, Lloyd LS, Okimoto OR, Sabnis SA, Nakakura NE, Corvera CC, Zimel ZM, Horvai HA, Cho CS, Wustrack WR, Gottschalk GA, O'Donnell OR, Jahan JT, Braunstein BS. .
      View in: Publisher Site   Mentions:
    17. Intraoperative Radiotherapy Without External Beam Radiotherapy in the Management of Primary Soft Tissue Sarcomas of the Extremities. International Journal of Radiation Oncology • Biology • Physics. 2020 Nov 1; 108(3):e5. Chen CW, Lometti LM, Wustrack WR, Zimel ZM, O'Donnell OR, Horvai HA, Cho CS, Okimoto OR, Jahan JT, Gottschalk GA, Braunstein BS. .
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    18. Musculoskeletal Effects of Cancer and Cancer Treatment. J Am Acad Orthop Surg. 2020 Aug 15; 28(16):e716-e728. Wustrack R, Rao SS, Morris CD. PMID: 32769720.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    19. Risk of endoprosthetic infection and impact of health-related quality of life in patients with osteosarcoma and giant cell tumor of bone; a retrospective case-control study. Annals of Joint. 2020 Jul 1; 5(0):27-27. Butte BZ, Tanaka TK, Andaya AV, Zimel ZM, O’Donnell OR, Wustrack WR. .
      View in: Publisher Site   Mentions:
    20. Insurance impacts survival for children, adolescents, and young adults with bone and soft tissue sarcomas. Cancer Med. 2020 02; 9(3):951-958. Penumarthy NL, Goldsby RE, Shiboski SC, Wustrack R, Murphy P, Winestone LE. PMID: 31838786; PMCID: PMC6997066.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    21. Single cell Dissection of Resistance to anti-BCMA CAR-T cell Therapy. Clinical Lymphoma Myeloma & Leukemia. 2019 Oct 1; 19(10):e25-e26. Ledergor LG, McCarthy ME, Shah SN, Wong WS, Chang CH, Fan FF, Shao SE, Gray GL, Cheung CA, Kwek KS, Bylsma BS, Del Favero DS, Wustrack WR, Spitzer SM, Wolf WJ, Martin MT, Ye YJ, Fong FL. .
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    22. Use of three-dimensional printing and intraoperative navigation in the surgical resection of metastatic acetabular osteosarcoma. BMJ Case Rep. 2019 Sep 30; 12(9). Heunis JC, Cheah JW, Sabnis AJ, Wustrack RL. PMID: 31570349; PMCID: PMC6768338.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    23. Prospective study of percutaneous bone-anchored implants in transfemoral amputees: Brain-machine platform technology for external prosthetic control and feedback. 2013 6th International IEEE/EMBS Conference on Neural Engineering (NER). 2019 Mar 1; 13-16. Zaid ZM, Wustrack WR, Garibaldi GM, Geiger GE, Andaya AV, O'Donnell OR. .
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    24. Current Concepts in Orthopaedic Care Disparities. J Am Acad Orthop Surg. 2018 Dec 01; 26(23):823-832. Pandya NK, Wustrack R, Metz L, Ward D. PMID: 30180094.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    25. Methylene Blue-Guided Debridement as an Intraoperative Adjunct for the Surgical Treatment of Periprosthetic Joint Infection. J Arthroplasty. 2017 12; 32(12):3718-3723. Shaw JD, Miller S, Plourde A, Shaw DL, Wustrack R, Hansen EN. PMID: 28811108.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    26. Limb-Salvage Options in Growing Children with Malignant Bone Tumors of the Lower Extremity: A Critical Analysis Review. JBJS Rev. 2017 07; 5(7):e7. Morris CD, Wustrack RL, Levin AS. PMID: 28742715.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    27. Somatic and Germline TP53 Alterations in Second Malignant Neoplasms from Pediatric Cancer Survivors. Clin Cancer Res. 2017 Apr 01; 23(7):1852-1861. Sherborne AL, Lavergne V, Yu K, Lee L, Davidson PR, Mazor T, Smirnoff IV, Horvai AE, Loh M, DuBois SG, Goldsby RE, Neglia JP, Hammond S, Robison LL, Wustrack R, Costello JF, Nakamura AO, Shannon KM, Bhatia S, Nakamura JL. PMID: 27683180; PMCID: PMC5570538.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    28. Molecular Markers in Bone and Soft-Tissue Tumors. JBJS Rev. 2016 08 30; 4(8). Wustrack R, Cooper K, Weber K. PMID: 27603273.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    29. A Resident-led Initiative Improves Screening and Treatment for Vitamin D Deficiency in Patients with Hip Fractures. Clin Orthop Relat Res. 2017 Jan; 475(1):264-270. Lansdown DA, Whitaker A, Wustrack R, Sawyer A, Hansen EN. PMID: 27549989; PMCID: PMC5174045.
      View in: PubMed   Mentions:    Fields:    Translation:HumansPHPublic Health
    30. 152 A Prospective Controlled Trial of the Effect of Surgeon Cost Scorecards on Operating Room Surgical Cost Reduction. Neurosurgery. 2016 Aug 1; 63:161-162. Zygourakis ZC, Valencia VV, Moriates MC, Boscardin BC, Catschegn CS, Goldberg GA, Bozic BK, Hoo HK, Wustrack WR, Pitts PL, Dudley DA, Gonzales GR, Lawton LM. .
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    31. How Often Does Spindle Failure Occur in Compressive Osseointegration Endoprostheses for Oncologic Reconstruction? Clin Orthop Relat Res. 2016 Jul; 474(7):1714-23. Goldman LH, Morse LJ, O'Donnell RJ, Wustrack RL. PMID: 27106130; PMCID: PMC4887378.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    32. Total femoral and proximal tibial compressive osseointegration. Current Orthopaedic Practice. 2016 Jan 1; 27(2):231-235. Legaspi LK, Galan GT, Wustrack WR, O’Donnell OR. .
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    33. Intraoperative radiotherapy and limb-sparing surgery in the treatment of primary, non-metastatic extremity soft tissue sarcoma. Journal of Radiation Oncology. 2015 Sep 1; 4(3):299-307. Tinkle TC, Tsuji TS, Weinberg WV, Wustrack WR, Braunstein BS, Haas-Kogan HD, DuBois DS, Horvai HA, Jahan JT, O’Donnell OR, Gottschalk GA. .
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    34. Intraoperative Radiotherapy in the Management of Locally Recurrent Extremity Soft Tissue Sarcoma. Sarcoma. 2015; 2015:913565. Tinkle CL, Weinberg V, Braunstein SE, Wustrack R, Horvai A, Jahan T, O'Donnell RJ, Gottschalk AR. PMID: 26346118; PMCID: PMC4546758.
      View in: PubMed   Mentions: 6  
    35. Clinical features and outcomes of infants with Ewing sarcoma under 12 months of age. Pediatr Blood Cancer. 2015 Nov; 62(11):1947-51. Wong T, Goldsby RE, Wustrack R, Cash T, Isakoff MS, DuBois SG. PMID: 26173989.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    36. Abstract P13. Plastic & Reconstructive Surgery. 2015 May 1; 135(5S):133-134. Vaughn VC, Piper PM, Wustrack WR, Sbitany SH. .
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    37. Secondary malignant neoplasms among children, adolescents, and young adults with osteosarcoma. Cancer. 2014 Dec 15; 120(24):3987-93. Lee JS, DuBois SG, Boscardin WJ, Wustrack RL, Goldsby RE. PMID: 25116228.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    38. Risk factors for subtrochanteric and diaphyseal fractures: the study of osteoporotic fractures. J Clin Endocrinol Metab. 2013 Feb; 98(2):659-67. Napoli N, Schwartz AV, Palermo L, Jin JJ, Wustrack R, Cauley JA, Ensrud KE, Kelly M, Black DM. PMID: 23345099; PMCID: PMC3565107.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    39. Infectious, inflammatory, and metabolic diseases affecting the athlete's spine. Clin Sports Med. 2012 Jul; 31(3):535-67. Metz LN, Wustrack R, Lovell AF, Sawyer AJ. PMID: 22658001.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    40. Are women with thicker cortices in the femoral shaft at higher risk of subtrochanteric/diaphyseal fractures? The study of osteoporotic fractures. J Clin Endocrinol Metab. 2012 Jul; 97(7):2414-22. Napoli N, Jin J, Peters K, Wustrack R, Burch S, Chau A, Cauley J, Ensrud K, Kelly M, Black DM. PMID: 22547423; PMCID: PMC3387394.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    41. Compartment Syndrome of Thigh. Techniques in Orthopaedics. 2012 Mar 1; 27(1):47-52. MacLean MJ, Wustrack WR, Kandemir KU. .
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    42. Aseptic failure: how does the Compress(®) implant compare to cemented stems? Clin Orthop Relat Res. 2012 Mar; 470(3):735-42. Pedtke AC, Wustrack RL, Fang AS, Grimer RJ, O'Donnell RJ. PMID: 22045069; PMCID: PMC3270164.
      View in: PubMed   Mentions: 32     Fields:    Translation:Humans
    43. Gluteal Compartment Syndrome. Techniques in Orthopaedics. 2012 Mar 1; 27(1):43-46. MacLean MJ, Wustrack WR, Kandemir KU. .
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    44. Predictors of new and severe vertebral fractures: results from the HORIZON Pivotal Fracture Trial. Osteoporos Int. 2012 Jan; 23(1):53-8. Wustrack R, Seeman E, Bucci-Rechtweg C, Burch S, Palermo L, Black DM. PMID: 21691843.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    45. Teriparatide, vitamin D, and calcium healed bilateral subtrochanteric stress fractures in a postmenopausal woman with a 13-year history of continuous alendronate therapy. J Clin Endocrinol Metab. 2011 Jun; 96(6):1627-32. Gomberg SJ, Wustrack RL, Napoli N, Arnaud CD, Black DM. PMID: 21430030.
      View in: PubMed   Mentions: 48     Fields:    Translation:Humans
    46. Impact of zoledronic acid on severe vertebral fractures: Results from horizon-pivotal fracture trial. Bone. 2010 Jun 1; 47:s194-s195. Wustrack WR, Seeman SE, Bucci-Rechtweg BC, Palermo PL, Black BD. .
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    47. Thumb function and appearance in thrombocytopenia: absent radius syndrome. J Hand Surg Am. 2007 Feb; 32(2):157-61. Goldfarb CA, Wustrack R, Pratt JA, Mender A, Manske PR. PMID: 17275588.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
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