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Eileen Foy, MD, PhD

TitleAssistant Professor
SchoolUCSF School of Medicine
DepartmentPediatrics
Address600 16th St
San Francisco CA 94158
Phone415-476-0301
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoFellowship2013Pediatric Infectious Diseases
    University of California, San FranciscoResidency2010Pediatrics
    University of Texas, Southwestern Medical Center, DallasM.D., Ph.D.2007Ph.D. in Microbiology/Virology
    University of California, Los AngelesB.S.1998Microbiology and Molecular Genetics
    Collapse Awards and Honors
    UCSF, Department of Pediatrics2016Bleecher Junior Faculty Award
    UCSF2013Microbial Pathogenesis and Host Defense T32 awardee
    Pediatric Infectious Diseases Society2011  - 2013Pediatric Infectious Diseases Society (PIDS) Fellowship Award
    UCSF, Department of Pediatrics2010Lucy S. Crain, M.D. Award
    UT Southwestern2005Nominata Award
    UT Southwestern2005Ida M. Green Award
    UT Southwestern, Department of Microbiology2005S. Edward Sulkin Award
    UT Southwestern, Department of MIcrobilogy2004Best Journal Club Student Presentation Award
    UT Southwestern, Department of Microbiology2003  - 2005Department of Microbiology T32 Training Grant
    UCLA1998summa cum laude
    UCSF1998UCSF Summer Student Research Fellowship
    UCLA1997  - 1998President's Undergraduate Fellowship
    City of Hope1997City of Hope Summer Student Research Fellowship

    Collapse Overview 
    Collapse Overview
    Dr. Foy has spent the majority of her research training focused on understanding how pathogens and hosts interact to determine the outcome of infection. She received her BS from UCLA in Microbiology and Molecular Genetics and completed the Medical Scientist Training Program at UT Southwestern where she spent her graduate studies in the laboratory of Dr. Michael Gale Jr. elucidating how HCV subverts the host innate immune response. Upon completion of her pediatrics residency at UCSF, she continued on to a Pediatric Infectious Diseases fellowship where her postdoctoral studies in the lab of Dr. Raul Andino focus on enterovirus pathogenesis. In 2015, she joined the faculty in the Department of Pediatrics, Division of Infectious Diseases and Global Health.

    Her current research continues to focus on enteroviruses which are among the most common viral pathogens, causing 10-15 million infections per year in the United States alone. Belonging to the positive-stranded RNA Picornaviridae family, the enterovirus genus consists of over 100 members including poliovirus, coxsackie A/B, echoviruses and the more recently described and numbered enteroviruses (EV68-121). These viruses cause a diverse spectrum of disease including the more common upper respiratory, gastrointestinal and mucocutaneous forms to the more severe forms resulting in enteroviral sepsis in neonates and immunocompromised patients, or involvement of the heart (myocarditis, pericarditis) and CNS (meningitis, encephalitis, acute flaccid paralysis) in otherwise healthy individuals.

    In collaboration with Dr. Andino and others at UCSF, Dr. Foy has been involved in the generation and characterization of a global protein interaction network between enteroviruses and their host. This approach has provided a more comprehensive understanding of how these viruses interact with the host cell to both successfully propagate as well as navigate the host response to infection. Additionally, we have uncovered novel mechanisms through which the virus manipulates the host cell and Dr. Foy’s research is currently focused on following up on these findings. Her ultimate goal is to aid in the development of improved vaccine strategies and broad enteroviral therapeutics to treat children with devastating and life-threatening enterovirus infections through the knowledge gained through better molecular understanding of virus-host interactions.

    Dr. Foy is board certified in Pediatric Infectious Diseases and enjoys providing clinical care to the patients on the UCSF Benioff Children’s Hospital inpatient Pediatric Infectious Diseases consultation service as well as teaching house staff and medical students.


    Collapse Research 
    Collapse Research Activities and Funding
    Structural Analysis of VP4
    Bleecher Foundation Jul 1, 2016 - Jun 30, 2017
    Role: Prinicpal Investigator

    Collapse ORNG Applications 
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Winger BA, Foy E, Sud SR, MacKenzie JD, Pua HH, Lau AH, Heyman MB, Laszik Z, Tureen J. Mycobacterium bovis Enterocolitis in an Immunocompromised Host. J Pediatr Gastroenterol Nutr. 2016 Jul; 63(1):e17-9. PMID: 26020480.
      View in: PubMed
    2. Yoneyama M, Kikuchi M, Matsumoto K, Imaizumi T, Miyagishi M, Taira K, Foy E, Loo YM, Gale M, Akira S, Yonehara S, Kato A, Fujita T. Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity. J Immunol. 2005 Sep 1; 175(5):2851-8. PMID: 16116171.
      View in: PubMed
    3. Gale M, Foy E. Evasion of intracellular host defence by hepatitis C virus. Nature. 2005 Aug 18; 436(7053):939-45. PMID: 16107833.
      View in: PubMed
    4. Sumpter R, Loo YM, Foy E, Li K, Yoneyama M, Fujita T, Lemon SM, Gale M. Regulating intracellular antiviral defense and permissiveness to hepatitis C virus RNA replication through a cellular RNA helicase, RIG-I. J Virol. 2005 Mar; 79(5):2689-99. PMID: 15708988; PMCID: PMC548482.
    5. Li K, Foy E, Ferreon JC, Nakamura M, Ferreon AC, Ikeda M, Ray SC, Gale M, Lemon SM. Immune evasion by hepatitis C virus NS3/4A protease-mediated cleavage of the Toll-like receptor 3 adaptor protein TRIF. Proc Natl Acad Sci U S A. 2005 Feb 22; 102(8):2992-7. PMID: 15710891; PMCID: PMC548795.
    6. Foy E, Li K, Sumpter R, Loo YM, Johnson CL, Wang C, Fish PM, Yoneyama M, Fujita T, Lemon SM, Gale M. Control of antiviral defenses through hepatitis C virus disruption of retinoic acid-inducible gene-I signaling. Proc Natl Acad Sci U S A. 2005 Feb 22; 102(8):2986-91. PMID: 15710892; PMCID: PMC549461.
    7. Sumpter R, Wang C, Foy E, Loo YM, Gale M. Viral evolution and interferon resistance of hepatitis C virus RNA replication in a cell culture model. J Virol. 2004 Nov; 78(21):11591-604. PMID: 15479800; PMCID: PMC523295.
    8. Foy E, Li K, Wang C, Sumpter R, Ikeda M, Lemon SM, Gale M. Regulation of interferon regulatory factor-3 by the hepatitis C virus serine protease. Science. 2003 May 16; 300(5622):1145-8. PMID: 12702807.
      View in: PubMed
    9. Fredericksen B, Akkaraju GR, Foy E, Wang C, Pflugheber J, Chen ZJ, Gale M. Activation of the interferon-beta promoter during hepatitis C virus RNA replication. Viral Immunol. 2002; 15(1):29-40. PMID: 11952144.
      View in: PubMed
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