Eileen Foy, MD, PhD
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Title(s) | Assistant Clinical Professor, Pediatrics |
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School | School of Medicine |
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Address | Location Required Varies CA 00000
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Phone | 415-476-0301 |
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vCard | Download vCard |
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Biography University of California, San Francisco | Fellowship | 2013 | Pediatric Infectious Diseases | University of California, San Francisco | Residency | 2010 | Pediatrics | University of Texas, Southwestern Medical Center, Dallas | M.D., Ph.D. | 2007 | Ph.D. in Microbiology/Virology | University of California, Los Angeles | B.S. | 1998 | Microbiology and Molecular Genetics |
UCSF, Department of Pediatrics | 2016 | | Bleecher Junior Faculty Award | UCSF | 2013 | | Microbial Pathogenesis and Host Defense T32 awardee | Pediatric Infectious Diseases Society | 2011
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| 2013 | Pediatric Infectious Diseases Society (PIDS) Fellowship Award | UCSF, Department of Pediatrics | 2010 | | Lucy S. Crain, M.D. Award | UT Southwestern | 2005 | | Nominata Award | UT Southwestern | 2005 | | Ida M. Green Award | UT Southwestern, Department of Microbiology | 2005 | | S. Edward Sulkin Award | UT Southwestern, Department of MIcrobilogy | 2004 | | Best Journal Club Student Presentation Award | UT Southwestern, Department of Microbiology | 2003
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| 2005 | Department of Microbiology T32 Training Grant | UCLA | 1998 | | summa cum laude | UCSF | 1998 | | UCSF Summer Student Research Fellowship | UCLA | 1997
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| 1998 | President's Undergraduate Fellowship | City of Hope | 1997 | | City of Hope Summer Student Research Fellowship |
Overview Dr. Foy has spent the majority of her research training focused on understanding how pathogens and hosts interact to determine the outcome of infection. She received her BS from UCLA in Microbiology and Molecular Genetics and completed the Medical Scientist Training Program at UT Southwestern where she spent her graduate studies in the laboratory of Dr. Michael Gale Jr. elucidating how HCV subverts the host innate immune response. Upon completion of her pediatrics residency at UCSF, she continued on to a Pediatric Infectious Diseases fellowship where her postdoctoral studies in the lab of Dr. Raul Andino focus on enterovirus pathogenesis. In 2015, she joined the faculty in the Department of Pediatrics, Division of Infectious Diseases and Global Health.
Her current research continues to focus on enteroviruses which are among the most common viral pathogens, causing 10-15 million infections per year in the United States alone. Belonging to the positive-stranded RNA Picornaviridae family, the enterovirus genus consists of over 100 members including poliovirus, coxsackie A/B, echoviruses and the more recently described and numbered enteroviruses (EV68-121). These viruses cause a diverse spectrum of disease including the more common upper respiratory, gastrointestinal and mucocutaneous forms to the more severe forms resulting in enteroviral sepsis in neonates and immunocompromised patients, or involvement of the heart (myocarditis, pericarditis) and CNS (meningitis, encephalitis, acute flaccid paralysis) in otherwise healthy individuals.
In collaboration with Dr. Andino and others at UCSF, Dr. Foy has been involved in the generation and characterization of a global protein interaction network between enteroviruses and their host. This approach has provided a more comprehensive understanding of how these viruses interact with the host cell to both successfully propagate as well as navigate the host response to infection. Additionally, we have uncovered novel mechanisms through which the virus manipulates the host cell and Dr. Foy’s research is currently focused on following up on these findings. Her ultimate goal is to aid in the development of improved vaccine strategies and broad enteroviral therapeutics to treat children with devastating and life-threatening enterovirus infections through the knowledge gained through better molecular understanding of virus-host interactions.
Dr. Foy is board certified in Pediatric Infectious Diseases and enjoys providing clinical care to the patients on the UCSF Benioff Children’s Hospital inpatient Pediatric Infectious Diseases consultation service as well as teaching house staff and medical students.
Research ORNG Applications Bibliographic
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Enterovirus pathogenesis requires the host methyltransferase SETD3. Nat Microbiol. 2019 12; 4(12):2523-2537.
Diep J, Ooi YS, Wilkinson AW, Peters CE, Foy E, Johnson JR, Zengel J, Ding S, Weng KF, Laufman O, Jang G, Xu J, Young T, Verschueren E, Kobluk KJ, Elias JE, Sarnow P, Greenberg HB, Hüttenhain R, Nagamine CM, Andino R, Krogan NJ, Gozani O, Carette JE. PMID: 31527793.
View in: PubMed Mentions: 7 Fields: Translation: AnimalsCells
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Mycobacterium bovis Enterocolitis in an Immunocompromised Host. J Pediatr Gastroenterol Nutr. 2016 07; 63(1):e17-9.
Winger BA, Foy E, Sud SR, MacKenzie JD, Pua HH, Lau AH, Heyman MB, Laszik Z, Tureen J. PMID: 26020480.
View in: PubMed Mentions: Fields: Translation: HumansCells
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Erratum: Evasion of intracellular host defence by hepatitis C virus. Nature. 2005 Sep 1; 437(7056):290-290.
Michael Gale, Eileen M. Foy. .
View in: Publisher Site Mentions:
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Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity. J Immunol. 2005 Sep 01; 175(5):2851-8.
Yoneyama M, Kikuchi M, Matsumoto K, Imaizumi T, Miyagishi M, Taira K, Foy E, Loo YM, Gale M, Akira S, Yonehara S, Kato A, Fujita T. PMID: 16116171.
View in: PubMed Mentions: 540 Fields: Translation: HumansAnimalsCells
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Evasion of intracellular host defence by hepatitis C virus. Nature. 2005 Aug 18; 436(7053):939-45.
Gale M, Foy EM. PMID: 16107833.
View in: PubMed Mentions: 208 Fields: Translation: HumansAnimalsCells
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Regulating intracellular antiviral defense and permissiveness to hepatitis C virus RNA replication through a cellular RNA helicase, RIG-I. J Virol. 2005 Mar; 79(5):2689-99.
Sumpter R, Loo YM, Foy E, Li K, Yoneyama M, Fujita T, Lemon SM, Gale M. PMID: 15708988.
View in: PubMed Mentions: 360 Fields: Translation: HumansCells
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Immune evasion by hepatitis C virus NS3/4A protease-mediated cleavage of the Toll-like receptor 3 adaptor protein TRIF. Proc Natl Acad Sci U S A. 2005 Feb 22; 102(8):2992-7.
Li K, Foy E, Ferreon JC, Nakamura M, Ferreon AC, Ikeda M, Ray SC, Gale M, Lemon SM. PMID: 15710891.
View in: PubMed Mentions: 372 Fields: Translation: HumansCells
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Control of antiviral defenses through hepatitis C virus disruption of retinoic acid-inducible gene-I signaling. Proc Natl Acad Sci U S A. 2005 Feb 22; 102(8):2986-91.
Foy E, Li K, Sumpter R, Loo YM, Johnson CL, Wang C, Fish PM, Yoneyama M, Fujita T, Lemon SM, Gale M. PMID: 15710892.
View in: PubMed Mentions: 213 Fields: Translation: HumansCells
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Viral evolution and interferon resistance of hepatitis C virus RNA replication in a cell culture model. J Virol. 2004 Nov; 78(21):11591-604.
Sumpter R, Wang C, Foy E, Loo YM, Gale M. PMID: 15479800.
View in: PubMed Mentions: 38 Fields: Translation: HumansCells
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Regulation of interferon regulatory factor-3 by the hepatitis C virus serine protease. Science. 2003 May 16; 300(5622):1145-8.
Foy E, Li K, Wang C, Sumpter R, Ikeda M, Lemon SM, Gale M. PMID: 12702807.
View in: PubMed Mentions: 280 Fields: Translation: HumansCells
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Activation of the interferon-beta promoter during hepatitis C virus RNA replication. Viral Immunol. 2002; 15(1):29-40.
Fredericksen B, Akkaraju GR, Foy E, Wang C, Pflugheber J, Chen ZJ, Gale M. PMID: 11952144.
View in: PubMed Mentions: 31 Fields: Translation: HumansCells
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2002 | 1 | 2003 | 1 | 2004 | 1 | 2005 | 6 | 2016 | 1 | 2019 | 1 |
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