Hirotake Komatsu, MD, PhD

Title(s)Associate Adjunct Professor, Surgery
SchoolSchool of Medicine
Address513 Parnassus Avenue, HSE, #525A
San Francisco CA 94143
ORCID ORCID Icon0000-0003-0876-4809 Additional info
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Biological hypoxia in pre-transplant human pancreatic islets induces transplant failure in diabetic mice. Sci Rep. 2024 05 30; 14(1):12402. Kato H, Salgado M, Mendez D, Gonzalez N, Rawson J, Ligot D, Balandran B, Orr C, Quijano JC, Omori K, Qi M, Al-Abdullah IH, Mullen Y, Ku HT, Kandeel F, Komatsu H. PMID: 38811610; PMCID: PMC11137081.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    2. A novel approach to determine the critical survival threshold of cellular oxygen within spheroids via integrating live/dead cell imaging with oxygen modeling. Am J Physiol Cell Physiol. 2024 Apr 01; 326(4):C1262-C1271. Shang KM, Kato H, Gonzalez N, Kandeel F, Tai YC, Komatsu H. PMID: 38497111.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    3. Physiomimetic Fluidic Culture Platform on Microwell-Patterned Porous Collagen Scaffold for Human Pancreatic Islets. Cell Transplant. 2024 Jan-Dec; 33:9636897241249556. Kato H, Chen H, Shang KM, Izumi K, Koba N, Tsuchiya T, Kawazoe N, Quijano J, Omori K, Orr C, Qi M, Ku HT, Kandeel F, Tai YC, Chen G, Komatsu H. PMID: 38742734; PMCID: PMC11095165.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    4. Firefly Rats: Illuminating the Scientific Community in Transplantation Research. Cell Transplant. 2024 Jan-Dec; 33:9636897231224174. Kobayashi E, Hakamata Y, Enosawa S, Shang KM, Komatsu H. PMID: 38235662; PMCID: PMC10798091.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    5. A scalable human islet 3D-culture platform maintains cell mass and function long-term for transplantation. Am J Transplant. 2024 Feb; 24(2):177-189. Omori K, Qi M, Salgado M, Gonzalez N, Hui LT, Chen KT, Rawson J, Miao L, Komatsu H, Isenberg JS, Al-Abdullah IH, Mullen Y, Kandeel F. PMID: 37813189.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    6. Ubiquitous Luciferase Expression in "Firefly Rats" Does Not Alter the Pancreatic Islet Morphology, Metabolism, and Function. Cell Transplant. 2023 Jan-Dec; 32:9636897231182497. Gonzalez N, Kato H, Tixi W, Ortiz J, Orr C, Shih HP, Ku HT, Yee JK, Kandeel F, Mullen Y, Kobayashi E, Komatsu H. PMID: 37345228; PMCID: PMC10328002.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    7. Micropyramid-patterned, oxygen-permeable bottomed dish for high density culture of pancreatic islets. Biofabrication. 2022 Dec 20; 15(1). Myrick RJ, Shang KM, Betts JF, Gonzalez N, Rawson J, Izumi K, Koba N, Tsuchiya T, Kato H, Omori K, Kandeel F, Mullen Y, Tai YC, Botvinick E, Komatsu H. PMID: 36537072.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    8. Microwell culture platform maintains viability and mass of human pancreatic islets. Front Endocrinol (Lausanne). 2022; 13:1015063. Kato H, Miwa T, Quijano J, Medrano L, Ortiz J, Desantis A, Omori K, Wada A, Tatsukoshi K, Kandeel F, Mullen Y, Ku HT, Komatsu H. PMID: 36465665; PMCID: PMC9712283.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    9. Submilligram Level of Beetle Antifreeze Proteins Minimize Cold-Induced Cell Swelling and Promote Cell Survival. Biomolecules. 2022 10 28; 12(11). Omori K, Gonzalez I, Nguyen C, Raminani SN, Deleon VM, Meza P, Zamalloa J, Perez RG, Gonzalez N, Komatsu H, Al-Abdullah IH, Wen X. PMID: 36358934; PMCID: PMC9687565.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    10. Biodistribution of Intra-Arterial and Intravenous Delivery of Human Umbilical Cord Mesenchymal Stem Cell-Derived Extracellular Vesicles in a Rat Model to Guide Delivery Strategies for Diabetes Therapies. Pharmaceuticals (Basel). 2022 May 12; 15(5). Li J, Komatsu H, Poku EK, Olafsen T, Huang KX, Huang LA, Chea J, Bowles N, Chang B, Rawson J, Peng J, Wu AM, Shively JE, Kandeel FR. PMID: 35631421; PMCID: PMC9143655.
      View in: PubMed   Mentions: 5  
    11. Critical Considerations in Bioluminescence Imaging of Transplanted Islets: Dynamic Signal Change in Early Posttransplant Phase and Signal Absorption by Tissues. Pancreas. 2022 03 01; 51(3):234-242. Komatsu H, Kobayashi E, Gonzalez N, Rawson J, Ortiz J, Donohue C, Ku HT, Kandeel F, Mullen Y. PMID: 35584380.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    12. A Multiparametric Assessment of Human Islets Predicts Transplant Outcomes in Diabetic Mice. Cell Transplant. 2021 Jan-Dec; 30:9636897211052291. Komatsu H, Qi M, Gonzalez N, Salgado M, Medrano L, Rawson J, Orr C, Omori K, Isenberg JS, Kandeel F, Mullen Y, Al-Abdullah IH. PMID: 34628956; PMCID: PMC8504220.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    13. Early-Phase Luciferase Signals of Islet Grafts Predicts Successful Subcutaneous Site Transplantation in Rats. Mol Imaging Biol. 2021 04; 23(2):173-179. Komatsu H, Gonzalez N, Ortiz J, Rawson J, Omori K, Kandeel F, Mullen Y. PMID: 33140260.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    14. Intermittent normobaric oxygen inhalation enhances subcutaneous prevascularization for cell transplantation. Microvasc Res. 2020 11; 132:104070. Komatsu H, Gonzalez N, Kandeel F, Mullen Y. PMID: 32890600.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    15. High Fractions of Large Islets in Human Islet Preparations Detrimentally Affect Posttransplant Outcomes in Streptozotocin-Induced Diabetic Immunodeficient Mice. Pancreas. 2020 May/Jun; 49(5):650-654. Komatsu H, Salgado M, Gonzalez N, Medrano L, Rawson J, Omori K, Qi M, Al-Abdullah I, Kandeel F, Mullen Y. PMID: 32433402.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    16. A subcutaneous pancreatic islet transplantation platform using a clinically applicable, biodegradable Vicryl mesh scaffold - an experimental study. Transpl Int. 2020 07; 33(7):806-818. Komatsu H, Gonzalez N, Salgado M, Cook CA, Li J, Rawson J, Omori K, Tai YC, Kandeel F, Mullen Y. PMID: 32198960.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    17. Semi-Automated Assessment of Human Islet Viability Predicts Transplantation Outcomes in a Diabetic Mouse Model. Cell Transplant. 2020 Jan-Dec; 29:963689720919444. Salgado M, Gonzalez N, Medrano L, Rawson J, Omori K, Qi M, Al-Abdullah I, Kandeel F, Mullen Y, Komatsu H. PMID: 32410459; PMCID: PMC7586280.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
    18. Isolated pancreatic islet yield and quality is inversely related to organ donor age in rats. Exp Gerontol. 2019 12; 128:110739. Gonzalez N, Salgado M, Medrano L, Mullen Y, Komatsu H. PMID: 31634542; PMCID: PMC9347290.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    19. Optimizing Temperature and Oxygen Supports Long-term Culture of Human Islets. Transplantation. 2019 02; 103(2):299-306. Komatsu H, Rawson J, Medrano L, Cook CA, Barriga A, Gonzalez N, Salgado M, Omori K, Kandeel F, Tai YC, Mullen Y. PMID: 29781952.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimals
    20. Oxygen transporter for the hypoxic transplantation site. Biofabrication. 2018 12 07; 11(1):015011. Komatsu H, Cook CA, Gonzalez N, Medrano L, Salgado M, Sui F, Li J, Kandeel F, Mullen Y, Tai YC. PMID: 30524058.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    21. Surfactants Improve Live Cell Imaging of Human Pancreatic Islets. Pancreas. 2018 10; 47(9):1093-1100. Komatsu H, Omori K, Kandeel F, Mullen Y. PMID: 30142118.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    22. Impact of Oxygen on Pancreatic Islet Survival. Pancreas. 2018 May/Jun; 47(5):533-543. Komatsu H, Kandeel F, Mullen Y. PMID: 29621044; PMCID: PMC5943071.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimals
    23. Oxygen environment and islet size are the primary limiting factors of isolated pancreatic islet survival. PLoS One. 2017; 12(8):e0183780. Komatsu H, Cook C, Wang CH, Medrano L, Lin H, Kandeel F, Tai YC, Mullen Y. PMID: 28832685; PMCID: PMC5568442.
      View in: PubMed   Mentions: 56     Fields:    Translation:Humans
    24. Oxygenated thawing and rewarming alleviate rewarming injury of cryopreserved pancreatic islets. Biochem Biophys Res Commun. 2017 05 06; 486(3):817-823. Komatsu H, Barriga A, Medrano L, Omori K, Kandeel F, Mullen Y. PMID: 28351620.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    25. Determination of Islet Viability Using a Zinc-Specific Fluorescent Dye and a Semiautomated Assessment Method. Cell Transplant. 2016 10; 25(10):1777-1786. Komatsu H, Omori K, Parimi M, Rawson J, Kandeel F, Mullen Y. PMID: 26497578.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    26. Involvement of a proapoptotic gene (BBC3) in islet injury mediated by cold preservation and rewarming. Am J Physiol Endocrinol Metab. 2016 06 01; 310(11):E1016-26. Omori K, Kobayashi E, Komatsu H, Rawson J, Agrawal G, Parimi M, Oancea AR, Valiente L, Ferreri K, Al-Abdullah IH, Kandeel F, Takahashi M, Mullen Y. PMID: 27117005; PMCID: PMC4935146.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    27. Isolated human islets require hyperoxia to maintain islet mass, metabolism, and function. Biochem Biophys Res Commun. 2016 Feb 12; 470(3):534-538. Komatsu H, Kang D, Medrano L, Barriga A, Mendez D, Rawson J, Omori K, Ferreri K, Tai YC, Kandeel F, Mullen Y. PMID: 26801563.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    28. Clinicopathological features and surgical outcomes of adenosquamous carcinoma of the pancreas: a retrospective analysis of patients with resectable stage tumors. Surg Today. 2015 Mar; 45(3):297-304. Komatsu H, Egawa S, Motoi F, Morikawa T, Sakata N, Naitoh T, Katayose Y, Ishida K, Unno M. PMID: 24973941.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    29. A GNAS mutation found in pancreatic intraductal papillary mucinous neoplasms induces drastic alterations of gene expression profiles with upregulation of mucin genes. PLoS One. 2014; 9(2):e87875. Komatsu H, Tanji E, Sakata N, Aoki T, Motoi F, Naitoh T, Katayose Y, Egawa S, Unno M, Furukawa T. PMID: 24498386; PMCID: PMC3912139.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    30. Fulminant type of emphysematous pancreatitis has risk of massive hemorrhage. Clin J Gastroenterol. 2011 Aug; 4(4):249-254. Komatsu H, Yoshida H, Hayashi H, Sakata N, Morikawa T, Onogawa T, Motoi F, Rikiyama T, Katayose Y, Egawa S, Hirota M, Shimosegawa T, Unno M. PMID: 26189529.
      View in: PubMed   Mentions: 4     Fields:    
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