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A novel approach to determine the critical survival threshold of cellular oxygen within spheroids via integrating live/dead cell imaging with oxygen modeling. Am J Physiol Cell Physiol. 2024 Mar 18.
Shang KM, Kato H, Gonzalez N, Kandeel F, Tai YC, Komatsu H. PMID: 38497111.
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PubMed Mentions: Fields:
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Firefly Rats: Illuminating the Scientific Community in Transplantation Research. Cell Transplant. 2024 Jan-Dec; 33:9636897231224174.
Kobayashi E, Hakamata Y, Enosawa S, Shang KM, Komatsu H. PMID: 38235662; PMCID: PMC10798091.
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PubMed Mentions: Fields:
Translation:
Animals
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A scalable human islet 3D-culture platform maintains cell mass and function long-term for transplantation. Am J Transplant. 2024 Feb; 24(2):177-189.
Omori K, Qi M, Salgado M, Gonzalez N, Hui LT, Chen KT, Rawson J, Miao L, Komatsu H, Isenberg JS, Al-Abdullah IH, Mullen Y, Kandeel F. PMID: 37813189.
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PubMed Mentions:
1 Fields:
Translation:
HumansAnimals
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Ubiquitous Luciferase Expression in "Firefly Rats" Does Not Alter the Pancreatic Islet Morphology, Metabolism, and Function. Cell Transplant. 2023 Jan-Dec; 32:9636897231182497.
Gonzalez N, Kato H, Tixi W, Ortiz J, Orr C, Shih HP, Ku HT, Yee JK, Kandeel F, Mullen Y, Kobayashi E, Komatsu H. PMID: 37345228; PMCID: PMC10328002.
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PubMed Mentions:
1 Fields:
Translation:
Animals
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Micropyramid-patterned, oxygen-permeable bottomed dish for high density culture of pancreatic islets. Biofabrication. 2022 Dec 20; 15(1).
Myrick RJ, Shang KM, Betts JF, Gonzalez N, Rawson J, Izumi K, Koba N, Tsuchiya T, Kato H, Omori K, Kandeel F, Mullen Y, Tai YC, Botvinick E, Komatsu H. PMID: 36537072.
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PubMed Mentions:
2 Fields:
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Microwell culture platform maintains viability and mass of human pancreatic islets. Front Endocrinol (Lausanne). 2022; 13:1015063.
Kato H, Miwa T, Quijano J, Medrano L, Ortiz J, Desantis A, Omori K, Wada A, Tatsukoshi K, Kandeel F, Mullen Y, Ku HT, Komatsu H. PMID: 36465665; PMCID: PMC9712283.
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PubMed Mentions: Fields:
Translation:
Humans
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Submilligram Level of Beetle Antifreeze Proteins Minimize Cold-Induced Cell Swelling and Promote Cell Survival. Biomolecules. 2022 10 28; 12(11).
Omori K, Gonzalez I, Nguyen C, Raminani SN, Deleon VM, Meza P, Zamalloa J, Perez RG, Gonzalez N, Komatsu H, Al-Abdullah IH, Wen X. PMID: 36358934; PMCID: PMC9687565.
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PubMed Mentions: Fields:
Translation:
Animals
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Biodistribution of Intra-Arterial and Intravenous Delivery of Human Umbilical Cord Mesenchymal Stem Cell-Derived Extracellular Vesicles in a Rat Model to Guide Delivery Strategies for Diabetes Therapies. Pharmaceuticals (Basel). 2022 May 12; 15(5).
Li J, Komatsu H, Poku EK, Olafsen T, Huang KX, Huang LA, Chea J, Bowles N, Chang B, Rawson J, Peng J, Wu AM, Shively JE, Kandeel FR. PMID: 35631421; PMCID: PMC9143655.
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PubMed Mentions:
5
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Critical Considerations in Bioluminescence Imaging of Transplanted Islets: Dynamic Signal Change in Early Posttransplant Phase and Signal Absorption by Tissues. Pancreas. 2022 03 01; 51(3):234-242.
Komatsu H, Kobayashi E, Gonzalez N, Rawson J, Ortiz J, Donohue C, Ku HT, Kandeel F, Mullen Y. PMID: 35584380.
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PubMed Mentions: Fields:
Translation:
HumansAnimals
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A Multiparametric Assessment of Human Islets Predicts Transplant Outcomes in Diabetic Mice. Cell Transplant. 2021 Jan-Dec; 30:9636897211052291.
Komatsu H, Qi M, Gonzalez N, Salgado M, Medrano L, Rawson J, Orr C, Omori K, Isenberg JS, Kandeel F, Mullen Y, Al-Abdullah IH. PMID: 34628956; PMCID: PMC8504220.
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PubMed Mentions:
4 Fields:
Translation:
HumansAnimals
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Early-Phase Luciferase Signals of Islet Grafts Predicts Successful Subcutaneous Site Transplantation in Rats. Mol Imaging Biol. 2021 04; 23(2):173-179.
Komatsu H, Gonzalez N, Ortiz J, Rawson J, Omori K, Kandeel F, Mullen Y. PMID: 33140260.
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PubMed Mentions:
3 Fields:
Translation:
Animals
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Intermittent normobaric oxygen inhalation enhances subcutaneous prevascularization for cell transplantation. Microvasc Res. 2020 11; 132:104070.
Komatsu H, Gonzalez N, Kandeel F, Mullen Y. PMID: 32890600.
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PubMed Mentions:
2 Fields:
Translation:
Animals
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High Fractions of Large Islets in Human Islet Preparations Detrimentally Affect Posttransplant Outcomes in Streptozotocin-Induced Diabetic Immunodeficient Mice. Pancreas. 2020 May/Jun; 49(5):650-654.
Komatsu H, Salgado M, Gonzalez N, Medrano L, Rawson J, Omori K, Qi M, Al-Abdullah I, Kandeel F, Mullen Y. PMID: 32433402.
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PubMed Mentions:
4 Fields:
Translation:
HumansAnimals
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A subcutaneous pancreatic islet transplantation platform using a clinically applicable, biodegradable Vicryl mesh scaffold - an experimental study. Transpl Int. 2020 07; 33(7):806-818.
Komatsu H, Gonzalez N, Salgado M, Cook CA, Li J, Rawson J, Omori K, Tai YC, Kandeel F, Mullen Y. PMID: 32198960.
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PubMed Mentions:
4 Fields:
Translation:
Animals
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Semi-Automated Assessment of Human Islet Viability Predicts Transplantation Outcomes in a Diabetic Mouse Model. Cell Transplant. 2020 Jan-Dec; 29:963689720919444.
Salgado M, Gonzalez N, Medrano L, Rawson J, Omori K, Qi M, Al-Abdullah I, Kandeel F, Mullen Y, Komatsu H. PMID: 32410459; PMCID: PMC7586280.
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PubMed Mentions:
10 Fields:
Translation:
HumansAnimals
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Isolated pancreatic islet yield and quality is inversely related to organ donor age in rats. Exp Gerontol. 2019 12; 128:110739.
Gonzalez N, Salgado M, Medrano L, Mullen Y, Komatsu H. PMID: 31634542; PMCID: PMC9347290.
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PubMed Mentions:
5 Fields:
Translation:
HumansAnimals
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Optimizing Temperature and Oxygen Supports Long-term Culture of Human Islets. Transplantation. 2019 02; 103(2):299-306.
Komatsu H, Rawson J, Medrano L, Cook CA, Barriga A, Gonzalez N, Salgado M, Omori K, Kandeel F, Tai YC, Mullen Y. PMID: 29781952.
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PubMed Mentions:
9 Fields:
Translation:
HumansAnimals
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Oxygen transporter for the hypoxic transplantation site. Biofabrication. 2018 12 07; 11(1):015011.
Komatsu H, Cook CA, Gonzalez N, Medrano L, Salgado M, Sui F, Li J, Kandeel F, Mullen Y, Tai YC. PMID: 30524058.
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PubMed Mentions:
5 Fields:
Translation:
HumansAnimals
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Surfactants Improve Live Cell Imaging of Human Pancreatic Islets. Pancreas. 2018 10; 47(9):1093-1100.
Komatsu H, Omori K, Kandeel F, Mullen Y. PMID: 30142118.
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PubMed Mentions:
2 Fields:
Translation:
Humans
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Impact of Oxygen on Pancreatic Islet Survival. Pancreas. 2018 May/Jun; 47(5):533-543.
Komatsu H, Kandeel F, Mullen Y. PMID: 29621044; PMCID: PMC5943071.
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PubMed Mentions:
28 Fields:
Translation:
HumansAnimals
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Oxygen environment and islet size are the primary limiting factors of isolated pancreatic islet survival. PLoS One. 2017; 12(8):e0183780.
Komatsu H, Cook C, Wang CH, Medrano L, Lin H, Kandeel F, Tai YC, Mullen Y. PMID: 28832685; PMCID: PMC5568442.
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PubMed Mentions:
50 Fields:
Translation:
Humans
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Oxygenated thawing and rewarming alleviate rewarming injury of cryopreserved pancreatic islets. Biochem Biophys Res Commun. 2017 05 06; 486(3):817-823.
Komatsu H, Barriga A, Medrano L, Omori K, Kandeel F, Mullen Y. PMID: 28351620.
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PubMed Mentions:
2 Fields:
Translation:
Humans
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Determination of Islet Viability Using a Zinc-Specific Fluorescent Dye and a Semiautomated Assessment Method. Cell Transplant. 2016 10; 25(10):1777-1786.
Komatsu H, Omori K, Parimi M, Rawson J, Kandeel F, Mullen Y. PMID: 26497578.
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PubMed Mentions:
5 Fields:
Translation:
HumansAnimalsCells
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Involvement of a proapoptotic gene (BBC3) in islet injury mediated by cold preservation and rewarming. Am J Physiol Endocrinol Metab. 2016 06 01; 310(11):E1016-26.
Omori K, Kobayashi E, Komatsu H, Rawson J, Agrawal G, Parimi M, Oancea AR, Valiente L, Ferreri K, Al-Abdullah IH, Kandeel F, Takahashi M, Mullen Y. PMID: 27117005; PMCID: PMC4935146.
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PubMed Mentions:
5 Fields:
Translation:
HumansAnimalsCells
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Isolated human islets require hyperoxia to maintain islet mass, metabolism, and function. Biochem Biophys Res Commun. 2016 Feb 12; 470(3):534-538.
Komatsu H, Kang D, Medrano L, Barriga A, Mendez D, Rawson J, Omori K, Ferreri K, Tai YC, Kandeel F, Mullen Y. PMID: 26801563.
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PubMed Mentions:
15 Fields:
Translation:
HumansCells
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Clinicopathological features and surgical outcomes of adenosquamous carcinoma of the pancreas: a retrospective analysis of patients with resectable stage tumors. Surg Today. 2015 Mar; 45(3):297-304.
Komatsu H, Egawa S, Motoi F, Morikawa T, Sakata N, Naitoh T, Katayose Y, Ishida K, Unno M. PMID: 24973941.
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PubMed Mentions:
11 Fields:
Translation:
Humans
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A GNAS mutation found in pancreatic intraductal papillary mucinous neoplasms induces drastic alterations of gene expression profiles with upregulation of mucin genes. PLoS One. 2014; 9(2):e87875.
Komatsu H, Tanji E, Sakata N, Aoki T, Motoi F, Naitoh T, Katayose Y, Egawa S, Unno M, Furukawa T. PMID: 24498386; PMCID: PMC3912139.
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PubMed Mentions:
23 Fields:
Translation:
HumansCells
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Fulminant type of emphysematous pancreatitis has risk of massive hemorrhage. Clin J Gastroenterol. 2011 Aug; 4(4):249-254.
Komatsu H, Yoshida H, Hayashi H, Sakata N, Morikawa T, Onogawa T, Motoi F, Rikiyama T, Katayose Y, Egawa S, Hirota M, Shimosegawa T, Unno M. PMID: 26189529.
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PubMed Mentions:
4 Fields: